Title of Invention	TRISUBSTITUTED FURANS SUITABLE FOR THE PREPARATION OF FRAGRANCE COMPOSITIONS
Abstract	2,2-Disubstituted 5-methyl-2,5-dihydro- and 2,2-disubstituted 5-methyl-tetrahydrofurans of formula (I) wherein R1 and R2 have the same meaning as described in the specification are useful as odorants.

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■ORGANIC COMPOUNDS -> TRISUBSTITUTED FURANS SUITABLE FOR THE PREPARATION OF FRAGRANCE COMPOSITIONS* *Title changed by ISA The present invention relates to trisubstituted furans, namely 2,2-disubstituted 5-methyl-2,5-dihydro- and 2,2-disubstituted 5-methyl-tetrahydrofurans and their use as odorants. This invention relates furthermore to a method of their production and to fragrance compositions comprising them. In the fragrance industry there is a constant demand for new compounds that enhance or improve on odour notes, or impart new odour notes. It has now been found that certain trisubstituted furans constitute new powerful blackcurrant odorants devoid of any sulphur off-notes. Fruity, blackcurrant notes were first used in »Amazone« (Hermes, 1974), and became more and more trendy as top notes in perfumery as they can impart naturalness and freshness, and thus constitute attractive alternatives to hesperidic-citrus, lavender or aldehydic notes. Perfume examples for this recent trend include »Le Monde est beau« (Kenzo, 1997) and »ln Love Again« (Yves Saint Laurent, 1998). Since then, blackcurrant notes became very popular and are today widely used, not only in fine fragrances, but also in the cosmetics and toiletries segment. However, most blackcurrant odorants, such as Corps Cassis (4-methyl-4-methylsulfanylpentan-2-one) and Oxane (2-methyl-4-propyl[1,3]oxathiane) are sulphury compounds and intense, sulfury-smelling by-products which may lead to unpleasant off-notes. Thus, there is a specific need for new blackcurrant odorants devoid of sulphur. Accordingly, the present invention refers in one of its aspects to a compound of formula (I) wherein R1 is methyl, ethyl, propyl or iso-propyl; 30110PCT /25.07.06 *R2 is a branched C4 - C7 alkyl, e.g. tert-butyl, neopentyl, or /so-hexyl; C5 - C8 cycloalkyi, e.g. cyclohexane and cycloheptane; or mono- or disubstituted C5 or C6 cycloalkyi, such as methylcyclohexyl and dimethylcyclohexyl; and the bond between C-3 and C-4 is a single bond, or the dotted line together with the bond between C-3 and C-4 represents a double bond. The compounds according to the present invention contain several chiral centres, and as such may exist as a mixture of stereoisomers, or they may be resolved as isomerically pure forms. Resolving stereoisomers adds to the complexity of manufacture and purification of these compounds, and so it is preferred to use the compounds as mixtures of their stereoisomers simply for economic reasons. However, if it is desired to prepare individual stereoisomers, this may be achieved according to methodology known in the art, e.g. preparative HPLC and GC or by stereoselective synthesis. Particular preferred compounds of formula (I) are 2-tert-butyl-5-methyI-2-propyl-2,5-dihydrofuran, 2-tert-butyl-5-methyl-2-propyltetrahydrofuran, 2-tert-butyl-2-isopropyl-5-methyl-2,5-dihydrofuran, 2-tert-butyl-2-isopropyl-5-methyltetrahydrofuran, 2-tert-butyl-2-ethyl-5-methyl-2,5-dihydrofuran, 2-tert-butyl-2-ethyl-5-methyltetrahydrofuran, 2-tert-butyl-2,5-dimethyl-2,5-dihydrofuran, 2-tert-butyl-2,5-dimethyltetrahydrofuran, 2-(3',3'-dimethylcyclohexyl)-2,5-dimethyl-2,5-dihydrofuran, and 2-(3',3'-dimethylcyclohexyl)-2,5-dimethyltetrahydrofuran. The compounds according to the present invention may be used alone or in combination with a base material. As used herein, the "base material" includes all known odorant molecules selected from the extensive range of natural products and synthetic molecules currently available, such as essential oils, alcohols, aldehydes and ketones, ethers and acetals, esters and lactones, hetero- and macrocycles, as well as nitrogen-containing compounds, and/or in admixture with one or more ingredients or excipients conventionally used in conjunction with odorants in fragrance compositions, for example, carrier materials, and other auxiliary agents commonly used in the art. The following list comprises examples of known odoriferous molecules, which may be combined with the compounds of the present invention: 30110PCT /25.07.06 essential oils and extracts, e.g. angelica root oil, bergamot oil, blackcurrant absolute, buchu leaf oil, coriander oil, geranium oil, grapefruit oil, jasmine absolute, lavender oil, lime oil, neroli oil, oakmoss absolute, orris root oil, patchouli oil, petitgrain oil, rose oil, orylang-ylang oil. alcohols, e.g. citronellol, dimethyl benzyl carbinol, eugenol, geraniol, (3Z)-hex-3-enol, linalool, phenylethyl alcohol, Super Muguet®, terpineol, or Undecavertol®. aldehydes and ketones, e.g. Cetone V™, damascenone, heliotropine, a-hexylcinnam aldehyde, Iso E Super®, (3-ionone, Isoraldeine®, Silvial®, or vanillin. ethers and acetals. e.a Ambrox™, Oxane™ or Spirambrene™. esters and lactbnes, e.g. benzyl acetate, coumarin, Hedione®, or hexyl salicylate. hetero- and macrocycles, e.g. ambrettolide, ethylene brassylate, Exaltolide®, maltol, Moxalone™ or Nlirvanolide®. nitrogen-containing compounds, e.g. methyl anthranilate, Peonile®, or Stemone®. The compounds of the present invention may be used in a broad range of fragrance applications, e.g. in any field of fine and functional perfumery, such as perfumes, household products, laundry products, body care products and cosmetics. The compounds can be employed in widely varying amounts, depending upon the specific application and on the nature and quantity of other odourant ingredients. The proportion is typically from 0.001 to 5 weight percent of the application. In one embodiment, compounds of the present invention may be employed in a fabric softener in an amount of from 0.001 to 0.05 weight percent. In another embodiment, compounds of the present invention may be used in fine perfumery in amounts of from 0.1 to 5 weight percent, more preferably between 0.1 and 2 weight percent. However, these values are given only by way of example, since the experienced perfumer may also achieve effects or may create novel accords with lower or higher concentrations. 30I10PCT /25.07.06 The compounds of the present invention may be employed into the fragrance application simply by directly mixing the fragrance composition with the fragrance application, or they may, in an earlier step, be entrapped with an entrapment material, examples of which include polymers, capsules, microcapsules and nanocapsules, liposomes, film formers, absorbents such as carbon or zeolites, cyclic oligosaccharides and mixtures thereof, or they may be chemically bonded to substrates, which are adapted to release the fragrance molecule upon application of an external stimulus such as light, enzyme, or the like, and then mixed with the application. Thus, the invention additionally provides a method of manufacturing a fragrance application, comprising the incorporation of a compound of formula (I) as a fragrance ingredient, either by directly admixing the compound to the application or by admixing a fragrance composition comprising a compound of formula (I), which may then be mixed to a fragrance application, using conventional techniques and methods. As used herein, "fragrance application" means any products, such as fine fragrances, e.g. eau de perfumes and eau de toilettes; household products, e.g. detergents for dishwasher, surface cleaner; laundry products, e.g. softener, bleach, detergent; body care products, e.g. shampoo, shower gel; and cosmetics, e.g. deodorants, vanishing cremes, comprising an odorant. This list of products is given by way of illustration and is not to be regarded as being in any way limiting. Compounds of formula (I) may be prepared by the reaction of magnesium Grignard reagent of 3-butyn-2-ol, prepared according to a general procedure well known in the art, with a corresponding ketone (R1R2CO) resulting in an alkynediol. The alkynediol is then hydrogenated in the presence of a Lindlar catalyst. Subsequent cyclisation of the formed c/s-configurated alkenediol in the presence of potassium hydrogensulfate results in the formation of the corresponding 5-methyl-2,5-dihydrofurane. Further compounds of formula (I) may be prepared by hydrogenation of the dihydorfuranes. The invention is now further described with reference to the following non-limiting examples. Example 1: 2-tert-Butvl-5-methvl-2-propvl-2,5-dihydrofuran Over a period of 30 min, a solution of 40.7 g (374 mmol) of ethyl bromide in 100 mL of dry tetrahydrofuran was added dropwise to a stirred suspension of 9.08 g (374 mmol) of 301I0PCT 125,01.06 . magnesium turnings in 5 mL of dry tetrahydrofuran, with the reaction being initiated by occasional heating with a heat gun. The reaction mixture was then stirred for additional 3 h at reflux. The reaction was allowed to cool down to room temp., and a solution of 12.6 g (180mmol) of but-3-yn-2-ol in 80 mL of dry tetrahydrofuran was added dropwise with stirring. The reaction mixture was then again heated to reflux for 4 h, prior to removal of the heating bath. At room temp., a solution of 25.0 g (195 mmol) of 2,2- dimethylhexan-3-one in 90 mL of dry tetrahydrofuran was added with stirring within 35 min, and the reaction mixture was refluxed for another 2 d with stirring. The reaction mixture was then allowed to cool to room temp., and quenched with 500 mL of an aqueous satd. NH4CI solution. The aqueous layer was extracted three times with 500 mL of ether each, the combined organic extracts were dried with sodium sulfate, and the solvent was evaporated on a rotary evaporator to provide 32.3 g (90%) of crude 5- tert-butyloct-3-yne-2,5-diol as a slightly yellowish oil, which was employed without further purification. A solution of 20.8 g (105 mmol) of this product in 300 mL of ethanol was hydrogenated by stirring at ambient pressure and temp, in an atmosphere of hydrogen in the presence of 3.11 g (2.92 mmol) of 10% palladium on barium sulfate and 300 mg (2.32 mmol) of quinoline. After 10 h of stirring, the catalyst was filtered off over a pad of Celite, and the solvent was removed on a rotary evaporator to provide 20.6 g (99%) of crude (3Z)-5-tert-butyloct-3-ene-2,5-diol, of which 19.6 g (98 mmol) was heated for 45 min in a Kugelrohr apparatus to 155°C /280 mbar in the presence of 2.00 g (14.7 mmol) of KHSO4. The evaporating reaction product was trapped in a bulb at-80 °C, and further purified by flash chromatography (400 g of silica-gel, pentane/ether, 98:2) to afford 7.26 g of product. This was then distilled in a Kugelrohr apparatus to furnish at 70-80°C / 20 mbar 6.24 g (34%) of the title compound as a colorless odoriferous liquid. IR (film): v = 1110 /1047 (v C-O-C), 1365 /1353 (δ S CH3), 977 (δ C=C-H), 1466 /1480 (δ as CH3), 1715 (y C=C, ring), 3074 (v C=C-H) cm"1. - 1H NMR (CDCI3): 5 = 0.88 / 0.91 (t, J = 7.0 Hz, 3H, 3"-H3), 0.90 (s, 9H, 1 '-Me3), 1.23 / 1.25 (2d, J = 6.5 Hz, 3H, 5-Me), 1.42-1.50 (m, 2H, 2"-H2), 1.68-1.74 (m, 2H, 1 n-H2), 4.87-4.88 (m, 1H, 5-H), 5.55 / 5.57 (2dd, J = 6.0, 2.5 Hz, 1H, 4-H), 5.70 / 5.72 (2d, J = 6.0 Hz, 1H, 3-H). - 13C NMR (CDCI3): 5 = 14.97 15.0 (2q, C-3"), 17.2 / 17.4 (2t, C-2"), 18.4 / 18.7 (2q, 5-Me), 21.4/ 21.8 (2t, C-1"), 26.1 / 26.7 (2q, 1 '-Me3), 35.5 / 37.2 (2s, C-1'), 82.8 / 82.9 (2d, C-5), 98.4 /98.6 (2s, C-2), 130.2/130.5/ 131.2/131.7 (4d, C-3,-4). - MS (El): m/e (%) = 57(17) 30110PCT /25.07.06 [C4H9+], 83 (9) [C5H7O+], 125 (100) [M+ - C4H9], 139 (8) [M+ - C3H7], 167 (5) [M+ CH3]. Odor description: Blackcurrant, natural, rich, eucalyptus buds, anis, buchu leaves, slightly green. Example 2: 2-tert-Butyl-5-methvl-2-propyltetrahvdrofuran At ambient temp., a suspension of 2.91 g (10.4 mmol) of 2-tert-butyl-5-methyl-2-propyl-2,5-dihydrofuran and 1.06 g (1.00 mmol) of 10% palladium on activated charcoal in 60 mL of dry ether was hydrogenated for 4 h in a Parr apparatus at 2.5 bar hydrogen pressure. The patalyst was filtered off over a pad of Celite, and the solvent evaporated. The resulting residue was distilled in a Kugelrohr apparatus to provide at 75-85°C / 20 mbar 2.43 g (80%) of the title compound as a colorless odoriferous liquid. IR (film): v = 11J10 /1088 (v OO-C), 1379 /1365 (5S CH3), 1466 /1480 (5as CH3), 985 (vr CH2) cm"1. - ]H NMR (CDCI3): 8 =0.88 / 0.91 (t, J = 7.0 Hz, 3H, 3n-H3), 0.90 (s, 9H, 1'-Me3), 1.19/1:21 (2d, J = 6.0Hz, 3H, 5-Me), 1.33-1.40 (m, 2H, 2"-H2), 1.41-1.45 (m, 2H, 1"-H2), 1.6&-1.76 (m, 2H, 3-H2), 1.79-1.88 (m, 2H, 4-H2), 4.05 (br. quint, J = 6.0 Hz, 1H, 5-H). - 13C NMR (CDCI3): 5 = 15.2 /15.3 (2q, C-3"), 18.0 /18.2 (2t, C-2'1), 21.2 / 21.3 (2q, 5-Me),' 26.3 / 26.3 (2q, 1 '-Me3), 31.2 / 31.5 (2t, C-4), 35.7 / 36.0 (2t, C-3), 38.2 / 38.7 (2t, C-1"), 39.5 / 39.6 (2s, C-1'), 76.6 / 77.0 (2d, C-5), 89.0 / 90.2 (2s, C-2). - MS (El): m/e(%)= 57 (30) [C4H9], 71 (100) [M+ - C8H17], 85 (6) [C4H9O+], 127 (76) [M+-C4H9], 141 (5)[M+-C3H7], 169 (5) [M+-CH3]. Odor description: Blackcurrant, damascene, sweet, natural, rich, with green, piny, eucalyptus and mjnt-like facets. Example 3: 2'tert-Butvl-2-isopropvl-5-methvl-2,5-dihvdrofuran Following the general procedure of example 1, 5-isopropyl-6,6-dimethylhept-3-yne-2,5-diol was prepared in 78% yield by reaction of 2,2,4-trimethylpentan-3-one with the previously prepared Grignard reagent of but-3-yn-2-ol. Lindlar hydrogenation of a solution of 18.1 g (90.0 mmol) of this material in 300 mL of dry ethanoi in the presence 30H0PCT /25.07.06 .of 2.20 g (2.07 mmol) of 10% palladium on barium sulfate and 320 mg (2.48 mmol) of quinoline according to example 1 provided after analogous work-up 17.9 g (99%) of (3Z)-5-isopropyl-6,6-dimethylhept-3-ene-2,5-diol, of which 17.2 g (85 mmol) was heated in a Kugelrohr apparatus to 155°C / 280 mbar in the presence of 1.71 g (12.5 mmol) of KHSO4 to furnish after trapping of the evaporating product at -80°C and flash chromatography (400 g of silica gel, pentane/ether, 98:2) 8.32 g of a colorless oil. This product was further purified by Kugelrohr distillation to afford at 80-90°C / 20 mbar 7.52 g (48%) of the title compound as a colorless odoriferous liquid. IR (film): v - 1111 /1079 (v C-O-C), 1366 /1353 (δ s CH3), 983 (δC=C-H), 1468 /1481 (δ as CH3), 1712 (V C=C, ring), 3071 (v C=C-H) cm"1. - 1H NMR (CDCI3): δ = 0.88 / 0.89 / 0.91 / 0.92 (4d,.J = 6.0 Hz, 6H, 1 "-Me2), 0.95 (s, 9H, 1 '-Me3), 1.23/1.26 (2d, J - 6.5 Hz, 3H, 5-Me), 2.12/2.26 (m, 1H, 1"-H), 4.80-4.86 (m, 1H, 5-H), 5.67 / 5.68 (2dd, J = 6.0, 2.5 Hz, 1H.4-H), 5.73 / 5.75 (2d, J = 6.0 Hz, 1H, 3-H). - 13C NMR (CDCI3): δ = 19.6 /19.7 (2q, 5-Me), 20.6 / 20.8 / 21.3 / 21.7 (4q, 1"-Me2), 26.5 / 27.2 (2q, 1'-Me3), 31.4 / 34.1 (2d, C-1"), 37.6/40.6 (2s, C-11), 82.1 / 82.2 (2d, C-5), 99.6 / 99.7 (2s, C-2), 128.5 / 128.6 /130.4 /131.1 (4d, C-3,-4). - MS (El): mle (%) = 57 (100) [C4H9+], 83 (45) [C5H7O+], 125 (67) [M+- C4H9], 139 (56) [M+ - C3H7], 167 (5) [M+ - CH3]. Odor description: Blackcurrant, fruity, grape, fresh with slightly metallic green nuances. Example 4: 2-ferf-Butvl-2-isopropvl-5-methvltetrahydrofuran Following the general procedure of example 2, 2-tert-butyl-2-isopropyl-5-methyltetrahydrofuran was prepared from 3.61 g (19.8 mmol) of 2-tert-butyl-2-isopropyl-5-methyl-2,5-dihydrofuran by hydrogenation in the presence of 1.21 g (1.14 mmol) of 10% palladium on activated charcoal. Purification of the crude product by Kugelrohr distillation at 85-95°C / 20 mbar furnished 3.42 g (93%) of the title compound as a colorless odoriferous liquid. IR (film): v = 1085 (v C-O-C), 993 (vrCH2), 1382 /1366 (δ S CH3), 1478 (δ as CH3) cm'1. -1H NMR (CDCI3):'.8 = 0.89/0.92 (2d, J = 6.5Hz, 6H, 1"-Me2), 0.94 (s, 9H, 1'-Me3), 1.19 /1.23 (2d, J = 6.0 Hz, 3H, 5-Me), 1.75-1.79 (m, 2H, 4-H2), 1.80-1.88 (m, 2H, 3-H2), 2.06 / 2.25 (2 sept., J = 7.0 Hz, 1H, 1"-H), 3.97-4.05 (m, 1H, 5-H). - 13C NMR (CDCI3): 30110 PCT /25.07.06 8 =19.7 / 20.6 (2q, 5-Me), 20.6 / 20.7 / 20.8 / 20.9 (4q, 1"-Me2), 26.8 / 27.0 (2q, 1'-Me3) 27.1 /27.2(2t, C-4), 29.2/ 33.3 (2d, C-1"), 34.4 / 35.9 (2t, C-3), 39.1 /40.1 (2s, C-1'), 75.8 / 76.0 (2d, C-5), 91.8 / 92.4 (2s, C-2). - MS (El): mle (%) = 57 (95) [C4H9+], 71 (100) [M+ - C8H17], 85 (17) [C5H9O+], 127 (61) [M+ - C4H9], 141 (77) [M+ - C3H7], 169 (5)[M+-CH3]. Odor description: Blackcurrant, fruity, green, sweet, coumarin-like with floral and camphoraceous undertones. Example 5: 2-tert-Butvl-2-ethvl-5-methyl-2,5-dihvdrofuran r Following the general procedure of example 1, 5-ethyl-6,6-dimethylhept-3-yne-2,5-diol was prepared in.'83% yield by reaction of 2,2-dimethylpentan-3-one with the previously prepared Grignatd reagent of but-3-yn-2-ol. Lindlar hydrogenation of a solution of 32.1 g (161 mmol) of this material in 400 ml_ of dry ethanol in the presence of 2.81 g (2.64 mmol) of 10% palladium on barium sulfate and 1.05 g (8.12 mmol) of quinoline provided after standard work-up 31.4 g (97%) of (3Z)-5-ethyl-6,6-dimethylhept-3-ene-2,5-diol, of which 21.2 g (112 mmol) was cyclised at 155°C / 280 mbar in the presence of 2.55 g (18.7 mmol) of KHSO4 to afford after purification by flash chromatography (600 g of silica gel, pentane/ether, 98:2) 10.1 g of the corresponding dihydrofuran. Distillation at 70-80°C / 20 mbar provided 6.62 g (36%) of the title compound as a colorless odoriferous liquid. IR (film): v = 11,02 /1084 (v C-O-C), 967 (8 C=C-H), 1365 / 1352 (5S CH3), 1465 /1479 (δ as CH3), 1705 (v C=C, ring), 3073 (v C=C-H) cm"1.- 1H NMR (CDCI3): § = 0.77 / 0.81 (2t, J = 7.5Hz, 3H, 2n-H3), 0.91 / 0.93 (2s, 9H, 1'-Me3), 1.24 /1.26 (2d, J = 6.5 Hz, 3H, 5-Me), 1.53-1.65 (m, 2H, 1 n-H2), 4.82-4.93 (m, 1H, 5-H), 5.54 / 5.56 (2dd, J = 6.0, 2.5 Hz, 1H, 4-H), 5.74 / 5.76 (2d, J = 6.0 Hz, 1H, 3-H). - 13C NMR (CDCI3): 8 = 8.1 / 9.3 (2q, C-2"), 21.1 / 21.4 (2q, 5-Me), 24.9 / 26.8 (2t, C-1"), 25.8 / 27.4 (2q, 1 '-Me3), 36.6 / 39.4 (2s, C-1'), 82.5 / 82.8 (2d, C-5), 98.4 / 98.7 (2s, C-2), 129.3 / 129.8 /131.2 / 131.8 (4d, C-3,-4). - MS (El): mle (%) = 57 (26) [C4H9+], 83 (6) [C5H7O+], 111 (100) [M+ - C4H9], 139 (9), [M+ - C2H5], 153 (3) [M+ - CH3]. 30H0PCT /25.07.06 Odor description: Camphoraceous, fruity, blackcurrant, fresh, with green-metallic and animalic nuances. Example 6: 2-tert-Butvl-2-ethyl-5-methvltetrahvdrofuran Analogous to the procedure of example 2, by hydrogenation of 3.12 g (18.4 mmol) of 2-ferf-butyl-2-isopropyl-5-methyl-2,5-dihydrofuran in the presence of 1.20 g (1.12 mmol) of 10% palladium on activated charcoal. Kugelrohr distillation of the reaction product provided at 70-80°C / 20 mbar 3.42 g (93%) of the title compound as a colorless odoriferous liquid. IR (film): v = 1106 / 1083 (v C-O-C), 977 (vr CH2), 1364 /1380 (δ S CH3), 1479 (δ as CH3) cm"1. - 1H NMR(CDCI3): 8 = 0.84-0.95 (m, 3H, 2"-H3), 0.90 / 0.92 (2s, 9H, 1'-Me3), 1.20 /1.22 (2d, J = 8.0 Hz, 3H, 5-Me), 1.36- 1.46 (m, 2H, 3-H2), 1.58-1.76 (m, 2H, 1"-H2), 1.79-1.93 (m, 2H, 4-H2), 3.94-4.11 (m, 1H, 5-H). - 13C NMR (CDCI3): 5 = 8.9/ 9.0 (2q, C-2"), 20.9 //21.0 (2q, 5-Me), 26.0 / 26.5 (2q, 1'-Me3), 27.9 / 28.0 (2t, C-1'), 28,7 / 30.2 (2t, C-3), 35.3 / 35.8 (2t, C-4), 38.0 / 39.3 (2s, C-1'), 76.5 / 76.7 (2d, C-5), 89.8 / 90.1 (2s, C-2). -MS (El): mle (%) = 57 (100) [C4H9+], 85 (7) [C5H9O+], 113 (59) [M+-C4H9], 141 (21)[M+-C2H5], 153(5)[M+-CH3]. Odor description: Fruity, minty, camphoraceous, blackcurrant, with metallic and animalic undertones. Example 7: 2-tert-Butyl-2,5-dimethvl-2,5-dihvdrofuran Following the general procedure of example 1, 5,6,6-trimethylhept-3-yne-2,5-diol was prepared in 96% yield by reaction of 3,3-dimethylbutan-2-one with the previously prepared Grignard reagent of but-3-yn-2-ol. Lindlar hydrogenation of 10.2 g (60.0 mol) of a solution of this material in 200 mL of dry ethanol in the presence of 960 mg (0.90 mmol) of 10% palladium on barium sulfate and 360 mg (2.78 mmol) of quinoline provided after the usual work-up 10.2 g (100%) (3Z)-5,6,6-trimethylhept-3-ene-2,5-dioi, of which 9.80 g (57.0 mmol) was cyclized in a Kugelrohr apparatus at 155°C / 280 mbar in the presence of 1.14 g (8.37 mmol) of KHSO4 to afford after flash chromatography (200 g of silica gel, pentane/ether, 98:2) 2.61 g of the corresponding dihydrofuran. 30110PCT /25.07.06 Distillation in vacuo at 45-50°C / 20 mbar provided 2.35 g (26%) of the title compound as colorless odoriferous liquid. IR (film): v = 1102 / 1095 (v C-O-C), 1367 /1350 (8, CH3), 946 (8 C=C-H), 1454 /1479 (δ as CH3), 1709 (v C=C, ring), 3075 (v C=C-H) cm"1. - 1H NMR (CDCI3): δ= 0.91 / 0.92 (2s, 9H, 1 -Me3), 1.21/1.22 (2s, 3H, 2-Me), 1.24 /1.26 (2d, J = 6.5 Hz, 3H, 5-Me), 4.82-4.92 (m, 1H, 5-H), 5.56 / 5.62 (2dd, J = 6.0, 1.5 Hz, 1H, 4-H), 5.76 / 5.79 (2d, J = 6.0 Hz, 1H, 3-H). - 13C NMR (CDCI3): 8 = 20.9 / 21.1 (2q, 5-Me), 23.3 / 24.2 (2q, 2-Me), 25.7 / 26.1 (2q, 1/-Me3), 36.2 / 38.3 (2s, C-1'), 80.1 / 82.4 (2d, C-5), 95.0 / 95.2 (2s, C-2), 129.8 /130.4;/132.1 /132.7 (4d, C-3,-4). - MS (El): mle (%) = 57 (10) [C4H9+], 83 (5) [C5H7O+J, 97:(100) [M+ - C4H9], 139 (5) [M+ - CH3]. Odor description:. Blackcurrant, citric, limette, green and slightly fatty. Example 8: 2-tert-Butvl-2,5-dimethyltetrahvdrofuran According to the'.procedure of example 2, by hydrogenation of 1.62 g (10.3 mmol) of 2-tert-butyl-2,5-dimethyl-2,5-dihydrofuran in the presence of 600 mg (0.56 mmol) of 10% palladium on activated charcoal. Kugelrohr distillation furnished at 45-50°C / 20 mbar 1.37 g (82%) of the title compound as a colorless odoriferous liquid. IR (film): v = 1102 (v C-O-C), 1368 / 1380 (δ s CH3), 1473 /1478 (δ as CH3), 953 (vr CH2) cm"1. - 1H NMR (CDCI3): 8 = 0.92 (s, 9H, 1'-Me3), 1.13/1.15 (2s, 3H, 2-Me), 1.19 /1.21 (2d, J = 6.0 Hz, 3H, 5-Me), 1.32-1.57 (m, 2H, 3-H2), 1.98-2.01 (m, 2H, 4-H2), 3.88-4.12 (m, 1H, 5-H). - 13C NMR (CDCI3): 8 = 20.9 / 22.4 (2q, 5-Me), 22.1 / 24.3 (2q, 2-Me), 25.7 (q, 1'-Me3), 26.5 / 27.3 (2t, C-3), 33.9 / 34.4 (2t, C-4), 36.8 / 37.8 (2s, C-1'), 73.6 (d, C-5), 87.6 (s, C-2). - MS (El): mle (%) = 57 (28) [C4H9+], 85 (5) [C4H9O+], 99 (100) [M+-C4H9], 141 (8)[M+-CH3]. Odor description: Green, camphoraceous, blackcurrant-like with some slight reminiscence to orange blossoms. 30110PCT /25.07.06 Example 9: 2-(3',3'-Dimethvlcvclohexvl)-2,5-dimethyl-2,5-dihvdrofuran Following the general procedure of example 1, 2-(3',3'-dimethylcyclohexyl)hex-3-yne-2,5-diol was prepared in 62% yield by reaction of 1-(3',3',dimethylcyclohexy)ethanone with the previously prepared Grignard reagent of but-3-yn-2-ol. Lindlar hydrogenation of 10.0 g (44.6 mmol) of a solution of this material in 250 mL of dry ethanol in the presence of 740 mg (0.695 mmol) of 10% palladium on barium sulfate and 290 mg (2.24 mmol) of quinoline provided after the usual work-up 9.82 g (97%) (3Z)-2-(3',3T-dimethylcyclohexyl)hex-3-ene-2,5-diol, which was cyclized in a Kugelrohr apparatus at 180°C / 20 mbar in the presence of 430 mg (3.16 mmol) of KHSO4. The resulting product was purified by flash chromatography (200 g of silica gel, pentane/ether, 99:1) and subsequent .Kugelrohr distillation to provide at 55-6Q°C /0.1 mbar 1.46 g (16%) of the title compound as colorless odoriferous liquid. IR (film): v = 824(5 C=C-H), 1085 /1105 (v C-O-C), 1366 /1350 (5S CH3), 970 (vr CH2), 1453 (δ as CH3) cm"1. - 1H NMR (CDCI3): 8 = 0.84-1.74 (m, 9H, 1 '-H, 2'-,4'-,5'-,6'-H2), 0.87/0.88 A0.90/0.91 (2s, 6H, 3'-Me2), 1.20/1.21 (2s, 3H, 2-Me), 1.24/1.25/ 1.25 / 1.26 {46, J = 6.5 Hz, 3H, 5-Me), 4.81-4.92 (m, 1H, 5-H), 5.62 / 5.64 / 5.64 / 5.65 (4dd, J = 6.0, 1,5 Hz, 1H, 4-H), 5.67 / 5.68 / 5.69 / 5.70 (4d, J = 6.0 Hz, 1H, 3-H). - 13C NMR (CDCI3): S = 14.0 / 21.5 / 21.6 / 22.3 (4q, 5-Me), 22.3 / 22.4 (2t, C-5'), 23.2/ 23.9 / 24.6 / 24.7 / 26.6 / 28.2 (6q, 2-Me, 3'-Me axial), 27.2 / 27.8 / 27.9 / 28.2 (4t, C-6'), 30.7 / 30.8 (2s, C-31), 33.6 / 34.1 (2q, 3'-Me equat), 39.1 / 39.2 (2t, C-2'), 40.7 / 41.4 (2t, C-4'), 42.3 / 42.5 /43.4 / 43.5 (4d, C-1'), 79.9 / 80.0 / 81.7 / 81.8 (4d, C-5), 92.3 / 92.4 / 92.5 / 92.6 (4s, C-2), 129.9 /130.0 /130.4 /130.5 /132.1 /132.2 / 132.6 /133.0 (8d, C-3,-4). - MS (El): m/e (%) = 43 (14) [C3H7+], 55 (6) [C4H7+], 69 (6) [C5H9+], 79 (4) [M+ -C8H15 - H2O], 97 (100) [M+ - C8Hi5], 175 (1) [M+ - CH3- CH3], 193 (1) [M+ - CH3], 208 Odor descriptiori Fruity, blackcurrant, grapefruit, natural, green tomato vine, with aspects of apple and rhubarb. Example 10: 2-(3',3'-Dimethvlcvclohexvl)-2.5-dimethvltetrahvdrofuran According to the procedure of example 2, by hydrogenation of 1.00 g (4.80 mmol) of 2- (3',3'-dimethylcyclohexyl)-2,5-dimethyl-2,5-dihydrofuran in the presence of 100 mg 30H0PCT /25.07.06 (0.0940 mmol) of 10% palladium on activated charcoal. Kugelrohr distillation furnished at 65-70°C / 0.1 mbar 690 mg (68%) of the title compound as a colorless odoriferous liquid. IR (film): v = 1094 (v C-O-C), 953 (vr CH2), 1455 (δ as CH3), 1374 (δ 9 CH3) cm"1. - 1H NMR (CDCI3): 5 = 0.82-1.82 (m, 11H, 1'-H, 3-,2'-A'-,5'-,6'-H2), 0.89 / 0.91 (2s, 6H, 3'-Me2), 1.10/1.11 (2s, 3H, 2-Me), 1.20 /1.23 (2d, J = 6.0 Hz, 3H, 5-Me), 1.93-2.09 (m, 2H, 4-H2), 3.94-4.09 (m, 1H, 5-H). - 13C NMR (CDCI3): 5 = 21.2/21.3/ 21.9 / 22.4 / 23.3 / 24.2 / 24.4/24.7 (q, 2-,5-Me, 3'-Me axial), 22.5 / 22.6 (2t, C-5'), 27.6 / 27.7 / 27.8 / 27.8 (4t, C-3), 30.7 / 30.8 (2s, C-3'), 33.7 / 33.8 (2q, 3'-Me equat.), 33.7 / 34.0 / 34.5 / 35.2 / 35.6 / 36,1 (6t, C-4,-6'), 39.4 / 40.8 / 41.0 / 41.2 (4t, C-2',-4'), 43.2 / 43.4 / 43.5 / 43.6 (4d, C-1'), 73.4 / 73.5 / 75.0 / 75.1 (4d, C-5), 85.0 / 85.1 (2s, C-2). - MS (El): mle (%) = 43 (38) (C3H7), 55 (9) [C4H7+], 69 (6) [C5H9+], 81 (3) [M+ - C8H15- H2O], 99 (100) [M+-C8H15], 111 (3)[C8H15+], 138(1)[C10H18+], 177 (1) [M+- CH3-H2O], 195 (2) [M+ -CH3]. Odor description: Sweet, floral-fruity, with green and blackcurrant-like facets. Example 11: Fruity-Floral Accord for Female Perfumes Ingredient Parts per weight 1. Benzyl acetate 40 2. 2-Cyclohexyl-2-phenylacetonitrile 80 3. Damascenone at 1% in dipropylene glycol 30 4. y-Decalactone 4 5. 3,7-Dimethyloct-6-en-1-ol 10 6. 1,1-Dimethyl-2-phenylethyl acetate 20 7. 1,1 -Dimethyl-2-phenylethyl butanoate 20 8. Ethyl butanoate 10 9. Ethyl maltol at 10% in dipropylene gtycol 4 10. Ethyl 2-methylbutanoate 2 11. Geraniol 240 30110PCT /25.07.06 12. 1a,3,34,6,6-hexamethyl-1a,2,3,4,5,6,7,7a-octahydronaphtho(2,3-b)oxirene at 50% in triethyl citrate 50 13. (3Z)-Hex-3-en-1-ol 4 14. (3Z)-Hex-3-en-1-yl acetate 4 15. 2-Hexylcyclopent-2-en-1-one at 10% in DPG 12 16. 2-Hexyl-3-phenylprop-2-enal 80 17. 3-(4-lsobutylphenyl)-2-methylpropanal 200 18. Methyl clihydrojasmonate 80 19. 8-Methyt-α-ionone 60 20. y-Undecalactone 10 21. 2-tert-Butyl-5-methyl-2-propyltetrahydrofuran 40 1000 2-tert-Bijtyl-5-methyl-2-propyltetrahydrofuran adds to this floral-fruity raspberry accord a sophisticated blackcurrant note, which conveys diffusivity, freshness and naturalness. Moreover, this compound rounds the composition off and increases the volume, without incorporating unpleasant sulphury connotation as is usually the case when employing blackcurrant odorants. Thereby, it turns this otherwise plain fruity accord into a solid foundation for a multifacet female fragrance. Example 12: Fruity-Green Fantasy Fragrance for Use in Cosmetics Ingredient Parts per weight > 1. 1,3-Benzodioxole-5-carboxaldehyde 16 2. 2-terf-Butylcyclohexyl acetate 80 3. Coumarin 24 4. Dihydromyrcenol 80 5. Ethyl acetqacetate 32 6. Ethyl 1,3-dioxolan-2-yl-2-methylacetate 16 7. Ethyl 3-methyl-3-phenylglycidate 4 8. Ethyl oxyhydrate 4 301I0PCT /25.07.06 9. (3Z)-Hex-3-en-1-yl acetate at 10% in DPG 8 10. Hexyl acetate ' 16 11. 4-(4-Hydroxyphenyl)-2-butanone (N112) at 10% in DPG 8 12. a-lonone 16 13. Iso-E-Super 32 14. Linalool 160 15. Linalyl acetate 130 16. Nonyl acetate 50 17. 3-Phenylprop-2-enal 4 18. 4-Methoxybenzaldehyde 80 19. 8-Methyl-a-ionone 160 20. 5-Methyl-3-heptanone oxime 16 21. 1,7,7-Trimethyl-2'-(isopropyl)spiro-(bicyclo[2.2.1 Jheptane- 2,4'-[1.,3]djoxane) at 50% in isopropyl myristate 32 22. y-Undecafactone 32 23. 2-(3',3'-Dimethylcyclohexyl)-2,5-dimethyl-2,5-dihydrofuran 10 1010 Though 2-(3',3'-dimethylcyclohexyl)-2,5-dimethyl-2,5-dihydrofuran is used in 1% only, it harmonizes the composition with a sophisticated, sparkling touch of blackcurrant. It brings naturalness to the composition and rounds off the fruity aspects of this fantasy fragrance for use in cosmetics. Example 13: Red Berries Fragrance for Use in Shampoo Ingredient Parts per weight 1. Allyl hexanoate 0.40 2. Allyl pentyloxyacetate 0.50 3. Benzaldehyde 2.00 4. 1,3-Benzodioxole-5-carboxaldehyde 6.00 5. 2-tert-Butylcyclohexyl acetate 70.00 30110PCT /25.07.06 6. 4-tert-Butylcyclohexyl acetate 1.00 7. 2-Cyclohexyl-2-phenylacetonitrile 5.00 8. α-Damascone 1.00 9. Decanal 0.60 10. Dihydromyrcenol 15.00 11. Dihydro-5-pentyl-2(3H)-furanone 10.00 12. 2,4-Dimethylcyclohex-3-enecarboxaldehyde 4.00 13. 3,7-Dimethylnona-2,6-dienenitrile 0.20 14. 3,7-Dimethytnona-1,6-dien-3-ol 60.00 15. 1,1 -Dimethyl-2-phenylethyl butanoate 3.00 16. Dipropylene glycol (DPG) 57.91 17. Dodecahydro-3a,6,6,9a-tetramethyl-naphto-(2,1b)-furan 0.10 18. Ethyl acetate 1.00 19. Ethyl acetoacetate 1.00 20. Ethyl butanoate 0.20 21. Ethyl 2-ethyl-6,6-dimethylcyclohex-2-enecarboxylate 5.00 22. Ethyl heptanoate 1.00 23. Ethyl maltol 0.10 24. Ethyl 2-methylbutanoate 2.00 25. 6-Ethyl-3-methyloct-6-en-1-ol 5.00 26. Ethyl 3-methyl-3-phenylglycidate 7.00 27. trans-8-Ethyl-1-oxaspiro[4.5]decan-2-one at 1% in triethyl citrate 2.00 28. Ethyl vanillin 0.05 29. 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran at 75% in diethyl phthalate 400.00 30. Hexyl salicyiate 140.00 31. 1-(4-Hydroxyphenyl)butan-3-one 70.00 32. p-lonone 28.00 33. Isoamyl acetate 5.00 34. Iso-E-Super 50.00 35. (-)-p-Menthan-3-ol 0.50 36. 4,7-Methano-1H-3a,4,5,6,7,7a-hexahydro-inden-6-yl acetate 5.00 37. 4-Methoxybenzaldehyde 0.50 38. Methoxyphenylbutanone 2.00 39. Methyl anthranilate 0.20 30110PCT 125.01.06 40. 4-Methyldec-3-en-5-ol 0.20 41. Methyl dihydrojasmonate 40.00 42. 2-Methyl-3-(4-isopropylphenyl)propanal 1.30 43. (E)-Methyl octa-4,7-dienoate 0.30 44. (10Z)-13-Methyloxacyclopentadec-10-en-2-one 5.00 45. c/s-2-Methyl-4-propyl-1,3-oxathiane at 50% in triethyl citrate 0.09 46. Phenoxyethyl isobutanoate 243.00 47. 2-Phenylethanol 30.00 48. 1-Phenylethyl acetate 2.00 49. Prenyl acetate 0.30 50. 2,4,4,7-Teframethylnona-6,8-dien-3-one oxime at 1% in benzyl laurate 0.50 51. 1 -(2,6,6-Trimethyl-2-cyclohexen-1 -ylhepta-1,6-dien-3-one 0.05 52. γ-Undecalactone 5.00 53. 2-(3',3'-Dimethylcyclohexyl)-2,5-dimethyl-2,5-dihydrofuran 10.00 1300 In a dosage of less than 1%, 2-(3',3'-dimethylcyclohexyl)-2,5-dimethyi-2,5-dihydrofuran adds to the composition a fruity, juicy aspect that imparts a sweet, sugary yet natural tonality. The dihydrofuran blends very well with the other compounds of this fruity fragrance/makes it rounder and more complex. Its blackcurrant note harmonizes very well with the musk and the floral ionone accord, without dominating the fragrance. Claims - Amended for national phase entry 1. A compound of formula (I) wherein R1 is methyl, ethyl, propyl or iso-propyl; R2 is a branched C4 - C7 alkyl, C5 - C8 cycloalkyl, or mono- or disubstituted C5 or C6 cycloalkyl; and * the bond between C-3 and C-4 is a single bond, or the dotted line together with the bond between C-3 and C-4 represents a double bond; with the proviso that the compound of formula (I) is not 2-isopentvl-2.5- dimethyltetrahvdrofuran. 2. A compound according to claim 1 selected from the group consisting of 2-tert-butyl-5- methyl-2-propyl-2,5-dihydrofuran, 2-tert-butyl-5-methyl-2-propyltetrahydrofuran, 2-tert- butyl-2-isopropyl-5-methyl-2,5-dihydrofuran, 2-tert-butyl-2-isopropyl-5- methyltetrahydrofuran, 2-tert-butyl-2-ethyl-5-methyl-2,5-dihydrofuran, 2-tert-butyl-2- ethyl-5-methyltetrahydrofuran, 2-tert-butyl-2,5-dimethyl-2,5-dihydrofuran, 2-tert-butyl- 2,5-dimethyltetrahydrofuran, 2-(3',3'-dimethylcyclohexyl)-2,5-dimethyl-2,5- dihydrofuranfl and 2-(3',3'-dimethylcyclohexyl)-2,5-dimethyltetrahydrofuran. 3. Use as odorant of a compound of formula (I) [as dofinod by claim 1 or 2] 30110 PCT-nat. phase /24.07.06 wherein R1 is methyl, ethvl. propyl oriso-propyl; R2 is a branched C4 - C7 alkyl. C5 - C8 cvcloalkvl. or mono- or disubstituted C5 or C8 cycloalkvl; and the bond between C-3 and C-4 is a single bond, or the dotted line together with the bond between C-3 and C-4 represents a double bond. 4. A flavour or fragrance composition comprising a compound of formula (I) as defined in claim [1 or] 2 or 3, 5. A method of manufacturing a flavour or fragrance composition, comprising the step of incorporating a compound of formula (I) as defined in claim [1 or] 2 or 3 into a base material. 6. A method of manufacturing a fragrance application, comprising the incorporation of a compound of formula (I) as defined in claim [1 or] 2 or 3, 7. A method according to claim 6 wherein the fragrance application is selected from the group consisting of perfumes, household products, laundry products, body care products and cosmetics. Dated this 14 day of September 2006 30110 PCT-nat. phase /24.07.06

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3333-CHENP-2006 CORRESPONDENCE OTHERS 06-07-2011.pdf

3333-CHENP-2006 AMENDED CLAIMS 10-08-2012.pdf

3333-CHENP-2006 AMENDED CLAIMS 12-01-2012.pdf

3333-CHENP-2006 CORRESPONDENCE OTHERS 10-08-2012.pdf

3333-CHENP-2006 EXAMINATION REPORT REPLY RECEIVED 12-01-2012.pdf

3333-CHENP-2006 FORM-13 12-01-2012.pdf

3333-CHENP-2006 FORM-3 12-01-2012.pdf

3333-CHENP-2006 OTHER PATENT DOCUMENT 12-01-2012.pdf

3333-CHENP-2006 POWER OF ATTORNEY 12-01-2012.pdf

3333-CHENP-2006 AMENDED CLAIMS 23-04-2012.pdf

3333-CHENP-2006 CORRESPONDENCE OTHERS 23-04-2012.pdf

3333-CHENP-2006 FORM-3 23-04-2012.pdf

3333-chenp-2006-abstract.pdf

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