Title of Invention

A METHOD OF TESTING THE ABILITY OF A TEST COMPOUND TO MODULATE THE ACTIVITY OF A POLYPEPTIDE OF THE JMJD2 SUBFAMILY OF JUMONJI PROTEINS

Abstract The present invention provides a method of testing the ability of a test compound to bind to and optionally modulate the activity of a protein of the JMJD2 subfamily of Jumonji proteins. The method comprises incubating a test compound with a protein of the JMJD2 subfamily of Jumonji proteins, a co-factor of said protein and, optionally, a substrate for demethylation. The method of the invention can be used for screening large numbers of compounds to identify a group of compounds that are candidate compounds for clinical use for treatment of certain cancers especially prostate cancers. Other compounds that do not have activity in the screening assays can be eliminated from further consideration as candidate compounds. The method of the invention therefore has utility in the pharmaceutical industry.
Full Text

Documents:

1919-mumnp-2008-abstract.doc

1919-mumnp-2008-abstract.pdf

1919-mumnp-2008-amended claims.pdf

1919-mumnp-2008-assignment(24-11-2008).pdf

1919-MUMNP-2008-CLAIMS(AMENDED)-(2-7-2012).pdf

1919-MUMNP-2008-CLAIMS(AMENDED)-(3-4-2012).pdf

1919-MUMNP-2008-CLAIMS(MARKED COPY)-(2-7-2012).pdf

1919-MUMNP-2008-CLAIMS(MARKED COPY)-(3-4-2012).pdf

1919-mumnp-2008-claims.doc

1919-mumnp-2008-claims.pdf

1919-MUMNP-2008-CORRESPONDENC(25-02-2009).pdf

1919-MUMNP-2008-CORRESPONDENCE(19-1-2012).pdf

1919-MUMNP-2008-CORRESPONDENCE(19-7-2012).pdf

1919-mumnp-2008-correspondence(21-11-2008).pdf

1919-MUMNP-2008-CORRESPONDENCE(24-11-2008).pdf

1919-MUMNP-2008-CORRESPONDENCE(3-3-2010).pdf

1919-MUMNP-2008-CORRESPONDENCE(6-1-2011).pdf

1919-MUMNP-2008-CORRESPONDENCE(7-1-2011).pdf

1919-mumnp-2008-correspondence.pdf

1919-MUMNP-2008-DECLARATION(24-11-2008).pdf

1919-mumnp-2008-description(complete).doc

1919-mumnp-2008-description(complete).pdf

1919-MUMNP-2008-DRAWING(3-4-2012).pdf

1919-mumnp-2008-drawing.pdf

1919-MUMNP-2008-EP DOCUMENT(19-7-2012).pdf

1919-MUMNP-2008-FORM 1(2-7-2012).pdf

1919-MUMNP-2008-FORM 1(24-11-2008).pdf

1919-mumnp-2008-form 1(8-9-2008).pdf

1919-mumnp-2008-form 1.pdf

1919-mumnp-2008-form 18(3-3-2010).pdf

1919-MUMNP-2008-FORM 2(TITLE PAGE)-(2-7-2012).pdf

1919-mumnp-2008-form 2(title page).pdf

1919-mumnp-2008-form 2.doc

1919-mumnp-2008-form 2.pdf

1919-MUMNP-2008-FORM 26(24-11-2008).pdf

1919-MUMNP-2008-FORM 3(19-1-2012).pdf

1919-MUMNP-2008-FORM 3(19-7-2012).pdf

1919-MUMNP-2008-FORM 3(24-11-2008).pdf

1919-MUMNP-2008-FORM 3(25-02-2009).pdf

1919-mumnp-2008-form 3(25-2-2009).pdf

1919-MUMNP-2008-FORM 3(6-1-2011).pdf

1919-mumnp-2008-form 3(8-9-2008).pdf

1919-mumnp-2008-form 3.pdf

1919-MUMNP-2008-FORM 5(24-11-2008).pdf

1919-mumnp-2008-form 5(8-9-2008).pdf

1919-mumnp-2008-form 5.pdf

1919-mumnp-2008-form 6(24-11-2008).pdf

1919-MUMNP-2008-OTHER DOCUMENT(7-1-2011).pdf

1919-mumnp-2008-pct-ib-304.pdf

1919-MUMNP-2008-PCT-IB-306(24-11-2008).pdf

1919-mumnp-2008-pct-ib-306.pdf

1919-mumnp-2008-pct-ipea-409.pdf

1919-mumnp-2008-pct-ipea-416.pdf

1919-MUMNP-2008-PETITION UNDER RULE 137(2-7-2012).pdf

1919-MUMNP-2008-REPLY TO EXAMINATION REPORT(2-7-2012).pdf

1919-MUMNP-2008-REPLY TO EXAMINATION REPORT(3-4-2012).pdf

1919-mumnp-2008-sequence listing.pdf

1919-mumnp-2008-wo international publication report a2.pdf

abstract1.jpg


Patent Number 253672
Indian Patent Application Number 1919/MUMNP/2008
PG Journal Number 33/2012
Publication Date 17-Aug-2012
Grant Date 10-Aug-2012
Date of Filing 08-Sep-2008
Name of Patentee KĂžbenhavns Universitet
Applicant Address Norregade 10 DK-1165 Knbenhavn K Denmark
Inventors:
# Inventor's Name Inventor's Address
1 CLOOS, PAUL C/O BIOTECH RESEARCH & INNOVATION CENTRE, OLE MAALOES VEJ 5, DK-2200 COPENHAGEN N.
2 AGGER, KARL C/O BIOTECH RESEARCH & INNOVATION CENTRE, OLE MAALOES VEJ 5, DK-2200 COPENHAGEN N.
3 CHRISTENSEN, JESPER C/O BIOTECH RESEARCH & INNOVATION CENTRE, OLE MAALOES VEJ 5, DK-2200 COPENHAGEN N.
4 HANSEN, KLAUS H C/O BIOTECH RESEARCH & INNOVATION CENTRE, OLE MAALOES VEJ 5, DK-2200 COPENHAGEN N.
5 HELIN, KRISTIAN C/O BIOTECH RESEARCH & INNOVATION CENTRE, OLE MAALOES VEJ 5, DK-2200 COPENHAGEN N.
PCT International Classification Number G01N33/68
PCT International Application Number PCT/DK2007/000128
PCT International Filing date 2007-03-14
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 PA200600400 2006-03-14 Denmark