Title of Invention

SUBSTITUTED IMIDAZOLE DERIVATIVES

Abstract

This invention is directed to substituted imidazole compounds which modulate the activity of KSP and are useful for the treatment of cancer and are represented by the formula (I) wherein: R1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo; R2 is selected from the group consisting of hydrogen, alkyl, and aryl; R3 is selected from the group consisting of hydrogen and -X-A, wherein X is selected from the group consisting of-C(O)-, -C(S)-, -S(O)-, -S(O)2, and -S(O)2-N(R)-, where R is hydrogen or alkyl; and A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents; R5 is selected from the group consisting of L-A1, wherein L is selected from the group consisting of-S(O)q- where q is one or two, and C1 to C5 alkylene optionally substituted with hydroxy, halo, or acylamino; and A1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl; and one of either R6 or R7 is selected from the group consisting of heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with -(R<SUP>8</SUP>)<SUB>m</SUB> where R<SUP>8</SUP> is as defined herein and m is an integer from 1 to 3, and the other Of R<SUP>6</SUP> or R<SUP>7</SUP> is selected from the group consisting of hydrogen, halo, and alkyl; or R<SUP>6</SUP> and R<SUP>7</SUP> are both hydrogen; the other substituents are defined in the claims.

Full Text

WO 2006/002236 PCT/US2005/022062 N-(1-(1-BENZYL -4-PHENYL-1H-IMIDAZOL-2-YL)-2,2-DIMETHYLPROPYL)BENZAMIDE DERIVAIVES AND RELATED COMPOUNDS AS KINESIN SPINDLE BROTBIN (KSP) INHIBITORS FOR THE TREATMENT OF CANCER [0001] This application claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Application Serial No. 60/580,927 filed June 18, 2004, which is hereby incorporated by reference in its entirety. BACKGROUND OF THE INVENTION Field of the Invention [0002] The present invention relates to substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of these compounds together with pharmaceutically acceptable carriers, and uses of these compounds. State of the Art [0003] Kinesins are motor proteins that use adenosine triphosphate to bind to microtubules and generate mechanical force. Kinesins are characterized by a motor domain having about 350 amino acid residues. The crystal structures of several kinesin motor domains have been resolved. [0004] Currently, about one hundred kinesin-related proteins (KRP) have been identified. Kinesins are involved in a variety of cell biological processes including transport of organelles and vesicles, and maintenance of the endoplasmic reticulum. Several KRPs interact with the microtubules of the mitotic spindle or with the chromosomes directly and appear to play a pivotal role during the mitotic stages of the cell cycle. These mitotic KRPs are of particular interest for the development of cancer therapeutics. WO 2006/002236 PCT/US2005/022062 [0005] Kinesin spindle protein (KSP) (also known as Eg5, HsEg5, KNSL1, or KIF11) is one of several kinesin-like motor proteins that are localized to the mitotic spindle and known to be required for formation and/or function of the bipolar mitotic spindle. [0006] In 1995, the depletion of KSP using an antibody directed against the C-terminus of KSP was shown to arrest HeLa cells in mitosis with monoastral microtubule arrays (Blangy et al., Cell 55:1159-1169,1995). Mutations in bimC and cut7 genes, which are considered to be homologues of KSP, cause failure in centrosome separation in Aspergillus nidulans (Enos, A.P., andN.R. Morris, Cell 50:1019-1027,1990) and Schizosaccharomyces pombe (Hagan, I., and M. Yanagida, Nature 347:563-566,1990). Treatment of cells with either ATRA (all trans-retinoic acid), which reduces KSP expression on the protein level, or depletion of KSP using antisense oligonucleotides revealed a significant growth inhibition in DAN-G pancreatic carcinoma cells indicating that KSP might be involved in the antiproliferative action of all trans-retinoic acid (Kaiser, A., et al., J. Biol. Chem. 274,18925-18931,1999). Interestingly, iheXenopus laevis Aurora-related protein kinase pEg2 was shown to associate and phosphorylate XlEg5 (Giet, R., et al., J. Biol. Chem. 274:15005-15013,1999). Potential substrates of wrora-related kinases are of particular interest for cancer drug development. For example, Aurora 1 and 2 kinases are overexpressed on the protein and RNA level and the genes are amplified in colon cancer patients. [0007] The first cell permeable small molecule inhibitor for KSP, "monastrol," was shown to arrest cells with monopolar spindles without affecting microtubule polymerization as do conventional chemotherapeutics such as taxanes and vinca alkaloids (Mayer, T.U., et al., Science 286:971-974,1999). Monastrol was identified as an inhibitor in phenotype-based 2 WO 2006/002236 PCT/US2005/022062 screens and it was suggested that this compound may serve as a lead for the development of anticancer drugs. The inhibition was determined not to be competitive in respect to adenosine triphosphate and to be rapidly reversible (DeBonis, S., et al., Biochemistry ¥2:338-349,2003; Kapoor, T.M., et al., J. CellBiol. 750:975-988,2000). [0008] In light of the importance of improved chemotherapeutics, there is a need for KSP inhibitors that are effective in vivo inhibitors of KSP and KSP-related proteins. SUMMARY OF THE INVENTION [0009] This invention is directed to substituted imidazole compounds which modulate the activity of KSP represented by the formula I: wherein: R1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ster, aryl, and alkyl optionally substituted with hydroxy or halo; R2 is selected from the group consisting of hydrogen, alkyl, and aryl; R3 is selected from the group consisting of hydrogen and -X-A, wherein X is selected rom the group consisting of-C(O)-, -C(S), -S(O)-, -S(O)2-, and -S(O)2-N(R)-, where R is ydrogen or alkyl; and A is selected from the group consisting of hydrogen, optionally substituted alkyl, ptionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, iptionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted ycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents 3 WO 2006/002236 PCT/US2005/022062 selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; or R1 and R3, together with the carbon atom attached to R1 and the nitrogen atom attached to R3 form a heterocyclic or substituted heterocyclic group; R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl, and -[alkylene]p-NR10R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl, or when R10 is hydrogen, Rll is hydroxy, alkoxy or substituted alkoxy; or when R1 and R3, together with the carbon and nitrogen atoms bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then R3 and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R5 is selected from the group consisting of L-A1, wherein L is selected from the group consisting of -S(O)q- where q is one or two, and C1 to C5 alkylene optionally substituted with hydroxy, halo, or acylamino; and A1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl; and 4 WO 2006/002236 PCT/US2005/022062 one of either R6 or R7 is selected from the group consisting of heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with -(R8)m where R8 is as defined herein and m is an integer from 1 to 3, and the other of R6 or R7 is selected from the group consisting of hydrogen, halo, and alkyl; or R6 and R7 are both hydrogen; R8 is selected from the group consisting of cyano, alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; or pharmaceutically acceptable salts, esters or prodrugs thereof. [0010] In another embodiment, the invention is directed to compounds represented by formula II: wherein: Ar is selected from the group consisting of phenyl, pyridinyl, pyrazinyl, and thiazolyl; X1 is selected from the group consisting of-C(O)- and -S(O)2-; A2 is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyl, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, halo, hydroxy, and nitro; A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted :ycloalkyl, 5 WO 2006/002236 PCT/US2005/022062 wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl, and -[alkylene]p-NR10R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl or when R10 is hydrogen, R11 is hydroxy, alkoxy or substituted alkoxy; or when R13 and A, together with the carbon atom and the X1 group bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then X1-A and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R8 is selected from the group consisting of cyano, alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; R12 is hydrogen, alkyl; R13 is alkyl or aryl; R13 and X1-A, together with the carbon atom attached to R13 and the nitrogen atom attached to X1 join to form a heterocyclic or a substituted heterocyclic group; 6 WO 2006/002236 PCT/US2005/022062 R14 is hydrogen or C1 to C4 alkyl; m1 is an integer equal to 0 to 2; n is an integer equal to 1 to 3; or pharmaceutically acceptable salts, esters or prodrugs thereof. [0011] In yet another embodiment, the invention is directed to compounds represented by formula III: wherein: X1 is-C(O)-or-S(O)2-; A2 is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyl, allof which may be optionally substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, halo, hydroxy, and nitro; A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl 7 WO 2006/002236 PCT/US2005/022062 or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; R8 is selected from the group consisting of alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen~containing substituted heteroaryl, and -[alkylene]p-NR10R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl or when R10 is hydrogen, R11 is hydroxy, alkoxy or substituted alkoxy; or when R15 and A, together with the carbon atoms and X1 bound respectively thereto, do not form a heterocyclic or substituted heterocyclic.group, then X1, A and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R15 is selected from the group consisting of ethyl, isopropyl, t-butyl, or phenyl; R15 and X1-A, together with the carbon atom attached to R15 and the nitrogen atom attached to X1 join to form a heterocyclic or a substituted heterocyclic group; R16 is hydrogen or methyl; R17 is hydrogen or methyl; m1 is an integer equal to 0,1 or 2; or pharmaceutically acceptable salts, esters or prodrugs thereof. [0012] In still another preferred embodiment, the compounds of this invention are represented by formula IV: 8 WO 2006/002236 PCT/US2005/022062 wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. [0013J In another embodiment, the compounds of this invention are represented by formula V: wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. [0014] In yet another embodiment, the invention is directed to compounds of formula VI: 9 WO 2006/002236 PCT/US2005/022062 wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. [0015] Also provided is a composition comprising a compound of formulae I- VII (including mixtures thereof) and a pharmaceutically acceptable excipient or carrier. Embodiments of the Invention [0016] The following embodiments are selected from embodiments in which the compound is any of formula I-VII, depending on the variable discussed. [0017] In one embodiment, R1 (or R13 or R15) is a group such as methyl, iso-propyl, f-butyl, l~methyl-«-prop-l-yl, phenyl, and 2-hydroxy-wo-propyl. [0018] In one embodiment, R2 (or R12 or R17) is a group such as hydrogen, methyl, and ethyl. [0019] In one embodiment, X or X1 is C(O) or S(O)2 and A is an unsubstituted group such as l,3-benzothiadiazol-4-yl, T-butoxy, butoxy, n-butoxy, carboxyl, cyclohexyl, 2,2-dimethylpropoxy, ethoxy, furan-3-yl, hydrogen, isoxazol-3-yl, methoxy, methyl, 2-methylpropoxy, phenyl, piperidin-3-yl, piperidin-4-yl, N-propoxy, pyridin-2-yl, pyrazin-2-yl, 10 WO 2006/002236 PCT/US2005/022062 tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydro-2H-pyran-4-yl, lH-tetrazol-1-yl, 2H-tetrazol-2-yl, and thiazol-4-yl. [0020] In another embodiment, X or X1 is C(O) or S(O)2 and A is an unsubstituted group such as l,3,4-thiadiazol-2-yl, l,3-benzothiadiazol-6-yl, 3,3-dihydrobenzo[l,2,3]thiadiazol-4-yl, benzimidazol-2-yl, benzimidazol-6-yl, benzo[l,2,5]thiadiazole, benzoxadiazol-4-yl, cyclopentyl, imidazol-4-yl, indazol-6-y, isooxazol-5-yl, morpholin-2-yl morpholino, oxazol-4-yl, piperidin-N-yl, pyrazol-3-yl, pyrrolidin-2-yl pyrrolidin-3-yl, pyrrolidin-N-yl, tetrazol-5-yl, and thiadiazol-4-yl. [0021] In one embpdiment, X or X1 is C(O) or S(O)2 and A is a substituted aryl or heteroaryl group such as 5-methyl-2H-imidazol-4yl, 2-aminothiazol-4-yl, 4-r-butylphenyl, 2-chlorophenyl, 2-chloro-6-methylpyrid-4-yl, 3-chlorophenyl, 4-chlorophenyl, 6-chloropyridin-3-yl, 3,4-dicblorophenyl, 2,4-difluorophenyl, l,5-dimethyl-lH-pyrazol-3-yl, 2,4-dimethylthiazol-5-yl, l-ethyl-3-methyl-lH-pyrazol-5-yl, 2-methoxyphenyl, 4-methoxyphenyl, 4-methylisoxazol-3-yl, 5-methylisoxazol-4-yl, 4-methylphenyl, l-methyl-3-trifluoromethyl-lH-pyrazol-4-yl, 1-methyl-5-chloro-lH-pyrazol-4-ylJ 5-methyl-lH-pyrazol-3-yl, 6-methylpyridin-3-yl, 2-pyrrolidin-3-ylphenyl, 4-(trifluoromethyl)phenyl, and 6-(trifluoromethyl)pyridin-3-yl. [0022] In another embodiment, X or X1 is C(O) or S(O)2 and A is a substituted aryl or heteroaryl group such as 2,5-dimethyloxazol-4-yl, 2-aminothiazol-4-yl, 4-methylpyrazol-5-yl, 3-trifluoromethylpyrazol-4-yl, 2-methyl-3-trifluoromethylpyrazol-5-yl, 4-chloro-l,3-dimethylpyrazolo[3,4]pyridine, and l-methylbenzimidazol-2-yl. 11 WO 2006/002236 PCT/US2005/022062 [0023] In one embodiment, X or X1 is C(O) or S(O)2 and A is a substituted heterocyclic or cycloalkyl group such as 3-[(aminoacetyl)amino]cyclohexyl and 3-(2-aminoethylsulfonylamino)cyclohexyl. [0024] In another embodiment, X or X1 is C(O) or S(O)2 and A is a substituted heterocyclic or cycloalkyl group such as l-methylpiperazin-4-yl, l-methylcarbonylpiperidin-4-yl, l-methoxycarbonylpiperidin-4-yl, quinuclidin-3-yl, 2-oxopyrrolidin-5-yl, 2-oxopyrrolidin-4-yl, 2-oxo-dihydrofuran-5-yl, 2-oxothiazolidin-4-yl, and 3-hydroxypyrrolidin-5-yl. [0025] In one embodiment, X or X1 is C(O) or S(O)2 and A is a substituted alkyl group such as 3-aimno-2-oxo-l(2H)-pyridinylmethyl, cyanomethyl, (N,N-dimethylamino)methyl, ethoxymethyl,p-fluorophenoxymethyl, hydroxymethyl, lH-imidazol-1-ylmethyl, methoxymethyl, (N-methylamino)methyl, methylsulfonylmethyl, (5-methyl-1H-tetrazol-l-yl)methyl, (5-methyl-2H-tetrazol-2-yl)methyl, morpholin-4-ylmethyl, lH-pyrazol-1-ylmethyl, lH-l,2,3-triazol-l-ylmethyl, 2H-l,2,3-triazol-2-yhnethyl, lH-l,2,4-triazol-l-ylmethyl, 2H-l,2,4-triazol-2-ylmethyl, 4H-l,2,4-triazol-4-ylmethyl, lH-tetrazol-1-ylmethyl, 1H-tetrazol-5-ylmethyl,and 2H-tetrazol-2-ylmethyl. [0026] In another embodiment, X or X1 is C(O) or S(O)2 and A is a substituted alkyl group such as imidazol-4-ylmethyl, l-methylpyrazol-3-ylmethyl, piperidin-4-ylmethyl, trifluoromethyl, dimethylaminoethyl, and2-oxo-3-aminopyrrolidin-l-ylmethyl. [0027] In one embodiment, X or X1 is C(O) or S(O)2 and R1 and R3 are cyclized to form a divalent heterocyclic group such as 2-oxopiperidin-N-6-yl or pyrrolidin-1-yl. [0028] In one embodiment, R3 and R4 (Or R4 / X1 -A) cyclize to form 1 -oxa-3,7-diazaspiro[4.4]nonan-2-one or 6-oxa-2,9-diazaspiro[4.5]decan-8-one. 12 WO 2006/002236 PCTAJS2005/022062 [0029] In one embodiment, A is N-methylaminoearbonyl. [0030] In one embodiment, R4 is a group such as hydrogen, piperidin-4-yl, -(CH2)2-NH2,-CH2-azetidin-3-yl, -CH2-(2,5-dihydropyrrol-3-yl), -(CH2)3-imidazol-l-yl, -CH2-(lH-imidazol-4-yl), -CH2-pyridin-3-yl, -CH2-(2-hydroxypyridin-4-yl)5 -CH2-(6-hydroxypyridin-3-yl), -CH2-morpholin-2-yl, -CH2-pyrrolidin-3-yl, -CH2-(3-fluoropyrrolidin-3-yl), -CH2-(3-hydroxypyrrolidin-3-yI), -CH2-(4-fluoropyrrolidin-3-yl), -CH2-(4-hydroxypyrrolidin-3-yl), -CH2-(2-hydroxymethylpyrrolidin-3-yl), -CH2-piperidin-3-yl, -CH2-[1H-(1,2,3-triazol-4-yl)], -CH2CH(NH2)CH2OH, -(CH2)3-OH, -(CH2)3-O(CO)-phenyl, -(CH2)3-NH2, -(CH2)3-NHCH3s -(CH2)3-N(CH3)2, -(CH2)3-NHOCH3, -(CH2)3-NHSO2CH3, -(CH2)3NH-(5-cyanopyridin-2-yl), -(CH2)3NH-cyclopropyl, -(CH2)3NH-cyclobutyl, -(CH2)3-(lH-imidazol-2-yl)s -(CH2)3-(2-hydroxyethylpiperidm-l-yl),-(CH2)3NH(2-hydroymethyphenyl),-(CH2)3NH-(-5- trifluoromethylpyridin-2-yl),-(CH2)3NHCH2-cyclopropyl, -(CH2)3NHCH2-{5-(pyridin-3-yloxy)-lH-indazol-3-yl},-(CH2)3NHCH2-(5-methoxy-lH-indazol-3-yl),-(CH2)3NHCH2-(6-fluoro-lH-indazol-3-yl), -CH2CHOHCH2NH2, -CH2CH(CH2OH)CH2NH2, -CH2C(CH3)2CH2-N(CH3)2, -CH2C(CH3)2CH-(-4-methylpiperazin-l-yl),-(CH2)2C(O)NH2,-(CH2)2CH(NH2)C(O)NH2, -(CH2)2CH(NH2)C(O)OH, -(CH2)2CH(NH2)CH2C(O)NH2, -(CH2)2CH(NH2)CH2OH, -(CH2)2CH(NH2)CH3,-(CH2)3NHC(O)CH2NH2,-(CH2)3NHC(O)CH(NH2)CH(CH3)2, -CH2CHFCH2NH2, -(CH2)2NHC(O)CH2NH2, -(CH2)3-NHCH2CH2OH, -(CH2)3-NHCH2CO2H, -(CH2)3-NHCH2CO2CH2CH3, -(CH2)3-N(CH2CH2OH)2, -(CH2)3-NHCH(CH2OH)2, -(CH2)3CH3, -(CH2)2CH(NH2)CH2OH, -(CH2)2C(CH3)2NH2, -(CH2)2CH(NH2)CH2OCH3, -(CH2)2CH(NH2)CH2F, -CH2CHFCH(NH2)CH2OH, and -(CH2)2spirocylcopropyl-NH2, 13 WO 2006/002236 PCT/US2005/022062 [0031] In one embodiment, L is methylene (n=l in formula II) and A1 or A2 is a group such as phenyl, 6-aminopyridin-2-yl, 3-chlorophenyl, 3-cyanophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 3,5-difluorophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-hydroxyphenyl, 3-methoxyphenyl, l-(5-methyl)-isoxazol-3-yI, 2-methylphenyl, 3-methylphenyl, 4-metb.ylphenyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, tetrahydropyran-4-yl, thiazol-4-yl, and 5-trifluoromethylfuran-2-yl. [0032] In one embodiment, R7 (R14/R16) is hydrogen, halo, or methyl and R6 (Ar-(R8)m1) is a group such as phenyl, 3-bromophenyl, 3-chlorophenyl, 4-cyanophenyl, 2,5-difluorophenyl, 3-fluorophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-methylphenyl, pyrazin-2-yl, pyridin-2-yl, thiazol-2-yl, 2-trifluoromethylphenyl, and 3-trifluoromethylphenyl. [0033] In another embodiment, R6 is hydrogen, halo, or methyl and R7 is a group such as 3-fluorophenyl. [0034] In one embodiment, m1 is 0,1 or 2. In another embodiment, n is 1. [0035] Embodiments of the invention also include the following: [0036] 1. A compound of formula I: wherein: 14 WO 2006/002236 PCT/US2005/022062 R1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo; R2 is selected from the group consisting of hydrogen, alkyl, and aryl; R3 is selected from the group consisting of hydrogen and -X-A, wherein X is selected from the group consisting of-C(O)-, -C(S), -S(O)-, -S(O)2-, and -S(O)2-N(R)-, where R is hydrogen or alkyl; and A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; or R1 and R3, together with the carbon atom attached to R1 and the nitrogen atom attached to R3 form a heterocyclic or substituted heterocyclic group; R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylenejp-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl, and -[alkylene]p-NR10R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and Rn are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, 15 WO 2006/002236 PCT/US2005/022062 heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl, or when R10 is hydrogen, R11 is hydroxy, alkoxy or substituted alkoxy; or when R1 and R3, together with the carbon and nitrogen atoms bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then R3 and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R5 is selected from the group consisting of L-A1, wherein L is selected from the group consisting of -S(O)q- where q is one or two, and C1 to C5 alkylene optionally substituted with hydroxy, halo, or acylamino; and A1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl; and one of either R6 or R7 is selected from the group consisting of heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with -(R8)m where R8 is as defined herein and m is an integer from 1 to 3, and the other of R6 or R7 is selected from the group consisting of hydrogen, halo, and alkyl; or R6 and R7 are both hydrogen; R8 is selected from the group consisting of cyano, alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; or pharmaceutically acceptable salts, esters or prodrugs thereof. [0037] 2. The compound of claim 1, wherein the compound is represented by formula II: 16 WO 2006/002236 PCT/US2005/022062 wherein:Ar is selected from the group consisting of phenyl, pyridinyl, pyrazinyl, and thiazolyl; X1 is selected from the group consisting of-C(O)- and -S(O)2-; A2 is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyl, all of which may be optionally substituted with i to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, halo, hydroxy, and nitro; A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen- 17 WO 2006/002236 PCT/US2005/022062 containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl, and -[alkylene]p-NR10R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted arnino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl or when R10 is hydrogen, R11 is hydroxy, alkoxy or substituted alkoxy; or when R13 and A, together with the carbon atom and the X1 group bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then X1-A and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R8 is selected from the group consisting of cyano, alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; R12 is hydrogen, alkyl; R13 is alkyl or aryl; R13 and X1-A, together with the carbon atom attached to R13 and the nitrogen atom attached to X1 join to form a heterocyclic or a substituted heterocyclic group; R14 is hydrogen or C1 to C4 alkyl; m1 is an integer equal to 0 to 2; n is an integer equal to 1 to 3; or pharmaceutically acceptable salts, esters or prodrugs thereof. [0038] 3. The compound of claim 1, wherein the compound is represented by formula III: 18 WO 2006/002236 PCT/US2005/022062 m wherein: X1 is-C(O)-or-S(O)2-; A2 is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyl, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, halo, hydroxy, and nitro; A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; R8 is selected from the group consisting of alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing 19 WO 2006/002236 PCT/US2005/022062 heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylenejp-nitrogen-containing substituted heteroaryl, and -[alkylene]p-NRI0R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of arnino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl or when R10 is hydrogen, R11 is hydroxy, alkoxy or substituted alkoxy; or when R15 and A, together with the carbon atoms and X1 bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then X1, A and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R15 is selected from the group consisting of ethyl, isopropyl, t-butyl, orphenyl; R15 and X1-A, together with the carbon atom attached to R15 and the nitrogen atom attached to X' join to form a heterocyclic or a substituted heterocyclic group; R16 is hydrogen or methyl; R17 is hydrogen or methyl; m1 is an integer equal to 0,1 or 2; or pharmaceutically acceptable salts, esters or 3prodrugs thereof. [0039] 4. The compound of claim 1, wherein the compound is represented by formula IV: 20 WO 2006/002236 PCT/US2005/022062 IV wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. [0040] 5. The compound of claim 1, wherein the compound is represented by formula V: V wherein X1, A, A2, R4, R8, R1S, R16, R17, and m1 are as defined above. [0041] 6. The compound of claim 1, wherein the compound is represented by formula VI: 21 WO 2006/002236 PCT/US2005/022062 VI wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. [0042] 7. The compound of claim 1, wherein R1 is selected from the group consisting of phenyl, methyl, iso-propyl, t-butyl, 1-methyl-H-prop-l-yl, and 2-hydroxy-iso-propyl. [0043] 8. The compound of claim 1, wherein R2 is selected from the group consisting of hydrogen, methyl, and ethyl. [0044] 9. The compound of claim ,1, wherein X or X1 is C(O) or S(O)2 and A is unsubstituted and selected from the group consisting of l,3-benzothiadiazol-4-yl, t-butoxy, butoxy, n-butoxy, carboxyl, cyclohexyl, 2,2-dimethylpropoxy, ethoxy, furan-3-yl, hydrogen, isoxazol-3-yl, methoxy, methyl, 2-methylpropoxy, phenyl, piperidin-3-yl, piperidin-4-yl, n-propoxy, pyridin-2-yl, pyrazin-2-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydro-2H-pyran-4-yl, 1H-tetrazol-l-yl, 2H-tetrazol-2-yl, thiazol-4-yl, l,3,4-thiadiazol-2-yl, 1,3-benzothiadiazol-6-yl, 3,3-dihydrobenzo[l,2,3']thiadiazol-4-yl, benzimidazol-2-yl, benzimidazol-6-yl, benzo[l,2,5]thiadiazole, benzoxadiazol-4-yl, cyclopentyl, imidazol-4-yl, indazol-6-y, 22 WO 2006/002236 PCT/US2005/022062 isooxazol-5-yl, morpholin-2-yl morpholino, oxazol-4-yl, piperidin-N-yl, pyrazol-3-yl, pyrrolidin-2-yl pyrrolidin-3-yl, pyrrolidin-N-yl, tetrazol-5-yl, and thiadiazol-4-yl. [0045] 10. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and A is a substituted aryl or heteroaryl group selected from the group consisting of 5-methyl-2H-imidazol-4-yl, 2-aminothiazol-4-yl, 4-t-butylphenyl, 2-chlorophenyl, 2-chloro-6-methylpyrid-4-yl, 3-chlorophenyl, 4-chlorophenyl, 6-chloropyridin-3-yl, 3,4-dichlorophenyl, 2,4-difluorophenyl, l,5-dimethyl-lH-pyrazol-3-yl, 2,4-dimethylthiazol-5-yl, l-ethyl-3-methyl-lH-pyrazol-5-yl, 2-methoxyphenyl, 4-methoxyphenyl, 4-methylisoxazol-3-yl, 5-methylisoxazol-4-yl, 4-methylphenyl, l-methyl-3-trifluorometyl-lH-pyrazol-4-yl, l-methyl-5-chloro-lH-pyrazol-4-yl, 5-methyl-lH-pyrazol-3-yl, 6-methylpyridin-3-yl, 2-pyrrolidin-3-ylphenyl, 4-(trifluoromeihyl)phenyl, 6-(trifluoromeihyl)pyridin-3-yl, 2,5-dimethyloxazol-4-yl, 2-aminothiazol-4-yl, 4-methylpyrazol-5-yl, 3-trifluoromethylpyrazol-4-yl, 2-methyl-3-trifluoromethylpyrazol-5-yl, 4-chloro-l,3-dimethylpyrazolo[3,4]pyridine, and 1-methylbenzimidazol-2-yl. [0046] 11. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and A is a substituted heterocyclic or cycloalkyl selected from the group consisting of 3-[(aminoacetyl)amino]cyclohexyl, 3-(2-aminoethylsulfonylamino)cyclohexyl, 1-methylpiperazin-4-yl, l-methylcarbonylpiperidin-4-yl, l-methoxycarbonylpiperidin-4-yl, quinuclidin-3-yl, 2-oxopyrrolidin-5-yl, 2-oxopyrrolidin-4-yl, 2-oxo-dihydrofuran-5-yl, 2-oxothiazolidin-4-yl, and 3-hydroxypyrrolidin-5-yl. [0047] 12. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and A is a substituted alkyl selected from the group consisting of 3-amino-2-oxo-l(2H)- 23 WO 2006/002236 PCT/US2005/022062 pyridinylmethyl, cyanomethyl, (N,N-dimethylamino)methyl, ethoxymethyl,j?-fluorophenoxymethyl, hydroxymethyl, lH-imidazol-1-ylmethyl, methoxymethyl, (N-methylamino)methyl, methylsulfonylmethyl,, (5-methyl-lH-tetrazol-l-yl)methyl, (5-methyl-2H-tetrazol-2-yl)methyl, morpholin-4-ylmethyl, lH-pyrazol-1-ylmethyl, lH-l,2,3-triazol-l-ylmethyl, 2H-l,2,3-triazol-2-ylmethyl, lH-l,2,4-triazol-l-ylmethyl, 2H-l,2,4-triazol-2-ylmethyl, 4H-l,2,4-triazol-4-ylmethyl, lH-tetrazol-l-ylmethyl, lH-tetrazol-5-ylmethyl, 2H-tetrazol-2-ylmethyl. imidazol-4-ylmethyl, l-methylpyrazol-3-ylmethyl, piperidin-4-ylmethyl, trifluoromethyl, dimethylaminoethyl, and 2-oxo-3-aminopyrrolidin-l-ylmethyl. [0048] 13. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and R1 and R3 are cyclized to form a divalent heterocyclic group such as 2-oxopiperidin-N-6-yl or pyrrolidin-1-yl. [0049] 14. The compound of claim 1, wherein A is N-methylarninocarbonyl. [0050] 15. The compound of claim 1, wherein R4 is selected from the group consisting of: hydrogen, piperidin-4-yl, -(CH2)2-NH2, -CH2-azetidin-3-yl, -CH2-(2,5-dihydropyrrol-3-yl), -(CH2)3-imidazol-l-yl} -CH2-(lH-imidazol-4-yl)5 -CH2-pyridin-3-yl, -CH2-(2-hydroxypyridin-4-yl), -CH2-(6-hydroxypyridin-3-yl), -CH2-morpholin-2-yl, -CH2-pyrrolidin-3-yl, -CH2-(3-fluoropyrrolidin-3-yl), -CH2-(3-hydroxypyrrolidin-3-yl), -CH2-(4-fluoropyrrolidin-3-yl), -CH2-(4-hydroxypyrrolidin-3-yl), -CH2-(2-hydroxymethylpyrrolidin-3-yl), -CH2-piperidin-3-yl, -CH2-[lH-(l,2J3-triazol-4-yl)]J -CH2CH(NH2)CH2OH, -(CH2)3-OH, -(CH2)3-O(CO)-phenyl, -(CH2)3-NH25 -(CH2)3-NHCH3, -(CH2)3-N(CH3)2, -(CH2)3-NHOCH3, -(CH2)3-NHSO2CH3, -(CH2)3NH-(5-cyanopyridin-2-yl), -(CH2)3NH-cyclopropyl, -(CH2)3NH-cyclobutyl, -(CH2)3-(lH.imidazol-2-yl),-(CH2)3-(2-hydroxyethylpiperidin-l-yl)5-(CH2)3NH(2- 24 WO 2006/002236 PCT/US2005/022062 hydroxymethylplienyl),-(CH2)3NH-(5-Mfluorome%lpyridm-2-yl),-(CH2)3NHCH2-cyclopropyl5-(CH2)3NHCH2-{5-(pyridin-3-yloxy)-lH-indazol-3-yl},-(CH2)3NHCH2-(5-methoxy-lH-indazol-3-yl),-(CH2)3NHCH2,-(6-fluoro-lH-indazol-3-yl),-CH2CHOHCH2NH2, -CH2CH(CH2OH)CH2NH2,-CH2C(CH3)2CH2-N(CH3)2,-CH2C(CH3)2CH2-(4-methylpipera2in-1-yl), -(CH2)2C(O)NH2, (CH2)2CH(NH2)C(O)NH2, -(CH2)2CH(NH2)C(O)OH, -(CH2)2CH(NH2)CH2C(O)NH2, -(CH2)2CH(NH2)CH2OH, -(CH2)2CH(NH2)CH3, -(CH2)3NHC(O)CH2NH2, -(CH2)3NHC(O)CH(NH2)CH(CH3)2, -CH2CHFCH2NH2, -(CH2)2NHC(O)CH2NH2, -(CH2)3-NHCH2CH2OH, -(CH2)3-NHCH2CO2H,-(CH2)3-NHCH2CO2CH2CH3! -(CH2)3-N(CH2CH2OH)2, -(CH2)3-NHCH(CH2OH)2, -(CH2)3CH3, -(CH2)2CH(NH2)CH2OH, -(CH2)2C(CH3)2NH2, -(CH2)2CH(NH2)CH2OCH3, -(CH2)2CH(NH2)CH2F3 -CH2CHFCH(NH2)CH2OH, and -(CH2)2spirocylcopropyl-NH2. [0051] 16. The compound of claim 1, wherein L is methylene and A1 is selected from the group consisting of phenyl, 6-aminopyridin-2-yl, 3-chloropfaenyl, 3-cyanophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 3,5-difluorophenyl, 2-lluorophenyl, 3-fiuorophenyl, 4-fluorophenyl, 3-hydroxyphenyl, 3-methoxyphenyl, l-(5-methyl)-isoxazol-3-yl, 2~methylpflenyl, 3-methylphenyl, 4-methylphenyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, tetrahydropyran-4-yl, thiazol-4-yl, and 5-trifluoromethylfuran-2-yl. [0052] 17. The compound of claim 1, wherein R7 is hydrogen, halo, or methyl. [0053] 18. The compound of claim 17, wherein R6 is selected from the group consisting of phenyl, 3-bromophenyl, 3-chlorophenyl, 4-cyanophenyl, 2,5-difiuorophenyl, 3- 25 WO 2006/002236 PCT/US2005/022062 fiuorophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-methylphenyl, pyrazin-2-yl, pyridin-2-yl, thiazol-2-yl, 2-trifluoromethylphenyl, and 3-trifluoromethylphenyl. [0054] 19. The compound of claim 1, wherein R6 is hydrogen, halo, or methyl. [0055] 20. The compound of claim 19, wherein R7 is a group such as 3-fiuorophenyl. [0056] 21. The compound of claim 1, wherein R3 and R4 cyclize to form 1 -oxa-3,7-diazaspiro[4.4]nonan-2-oneor6-oxa-2,9-diazaspiro[4.5]decan-8-one. [0057] 22. A compound selected from the group consisting of: N-(3-aminopropyl)-N-[(lR)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2-methylpropyl]-4-methylbenzamide; N N-(3-aminopropyl)-N-[(R)-(l -benzyl-4-phenyl-1 H-imidazol-2-yl)(phenyl)methyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(R)-(l-benzyl-4-phenyl-lH-imidazol-2-yl)(phenyl)methyl]benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -4-methylbenzamide; N-(3-aminopropyl)-N- {(1R)-1 -[1 -benzyl-4-(3-bromophenyl)-1 H-imidazol-2-yl]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2,4-difluorobenzamide; N-(3-aminopropyl)-4-methyl-N- {2-methyl-1 - [ 1 -(3 -methylbenzyl)-4-phenyl-1H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l~[l-benzyl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl}benzaniide; 26 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2,4-difluorobenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-arainopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyI}-2,4-difluorobenzamide; N-(3-aminopropyl)-N-{ (1R)-1 -[1 -benzyl-4-(4-methylphenyl)-1 H-imidazol-2-yl]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(4-methylphenyl)-lH-imidazol-2-yl]-2-methylpropyl} -4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(4-methylphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(4-methylphenyl)-lH-imidazol-2-yl]-2-methylpropyl} -2,4-difluorobenzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-4-methylbenzamide; N-(3-aminopropyI)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2)2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3,5-difluorobenzyl>4-phenyl-lH-imidazol-2-yl]-2-methylpropyl} -4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3,5-difluorobenzyl)-4-phenyl~lH-imidazol-2-yl]-2-methylpropyl}benzamide; N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methyl-N-{3-[(methylsulfonyl)amino]propyl}benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-[(3R)-piperidin-3-ylmethyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazbl-2-yl)-2-methylpropyl]-N-[(3S)-piperidin-3-ylmethyl]benzamide; 27 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-4-methyl-N-{(lR)-2-methyl-l-[l-(4-methylbenzyl)-4-phenyl-1 H-imidazol-2-yl]propyl Jbenzamide; N-(3-aminopropyl)-N-{(lR)-2-methyl-l-[l-(4-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-4-methyl-N-{(lR)-2-methyl-l-[l-(2-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-N-{(l R)-2-methyl-l -[1 -(2-methylbenzyl)-4-phenyl-1H-imidazol-2-yl]propyl}benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-[2,2-dimethyl-3-(4-metbylpiperazia-l-yl)propyl]benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-[2,2-dimethyl-3-(4-methylpiperazin-l-yl)propyl]~4-methylbenzamide; N-[( 1R) 1 -(1 -benzyl-4-phenyI-1 H-imidazol-2-yl)-2-methylpropyl] -4-methyI-N-[(3R)-piperidin-3 -ylmethyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methyl-N-[(3 S)-piperidin-3 -ylmethyl]benzamide; N-(3-aminopropyl)-N-((lR)-l-{l-benzyl-4-[2-(trifluoromethyl)phenyl]-lH-imidazol-2-yl}-2-methylpropyl)benzamide; N-(3-ajminopropyl)-N-((lR)-l-{l-benzyl-4-[2-(trifluoromethyl)phenyl]-lH-imidazol-2-yl}-2-methylpropyl)-4-methylbenzamide; N-(3-aminopropyl)-N-((lR)-l-{l-ben2yl-4-[2-(trifluoromethyl)phenyl]-lH-imidazol-2-yl}-2-methylpropyl)-2,4-difluorobenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-metb.oxyben2amide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-3-chlorobenzamide; N-(3-aminopropyl)-N-{(l.R)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -4-chlorobenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-tert-butylbenzamide; N-(3-aminopropyl)-N- {(1 R)-l -[1 -benzyl-4-(3-chlorophenyl)-1 H-imidazol-2-yl]-2-methylpropyl} -3,4-dichlorobenzamide; N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-N-{3-[(5-cyanopyridin-2-yl)amino]propyl}benzamide; N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-N-(3-{[5-(trifluoromethyl)pyridin-2-yl]amino}propyl)benzainide; 28 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-piperidin-4-ylbenzamide; N-[(lR)4-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methyl-N-piperidin-4-ylbenzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyI]-2,4-difluoro-N-piperidin-4-ylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}cyclohexanecarboxamide; NK3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -6-chloronicotinamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chloropb.enyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-4-methylben2amide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(2,4-difluoroben2yl)-lH-imidazol-2-yl]-2J2-dimethylpropyl}ben2amide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(2,4-difluorobenzyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-4-methylbenzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imida2»l-2-yl)-2-methylpropyl]-N-[3-(dimethylamino)-2,2-dimethylpropyl]benzamide; N-[(lR)-l-(l-ben2yl-4-phenyI-lH-iinidazol-2-yl)-2-methylpropyl]-N-[3-(dimethylamino)-2^-dimethylpropyl]-4-methylbeiizamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl} -6-chloronicotinamide; N-(3-aminopropyl)-6-chloro-N-{(lR)-l-[4-(3-chlorophenyl)-l-(3,5-difluorobenzyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}nicotinaniide;, N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-5-methyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]benzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-5-mefhyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-|;(lR)-l-(l-benzyl-5-methyl-4-phenyl-lH-iniida2ol-2-yl)-2-methylpropyl]-2,4-difluorobenzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-5-methyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-6-chloronicotinamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-chlorobenzamide; 29 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-chloro-6-methylisonicotinamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-3-furamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-5-methyl-2H-imidazole-4-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -2-methoxybenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}pyridine-2-carboxamide; N N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyMH-iinidazol-2-yl)-l,2-dimethylpropyljbenzamide; N-(3-aminopropyl>N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-l,2-dimethylpropyl]-4-methylbenzamide; N-(2-aminoethyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methylbenzamide; N-(2-aminoetiiyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-l,3-thiazole-4-carboxamide; N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3 -ylmethyl)benzamide; N-{(lR)-l-[4-(3-chlorophenyl)-l-(3}5-difluorobenzyl)-lH-imidazol-2-yl]-2,2~ dimethylpropyl}-N-(pyrrolidini-3-ylinethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}benzenesuifonamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylisoxazole-3-carboxamide; N-(3 -aminopropyl)-N- {(1 R)-l - [ 1 -benzyl-4-(3 -chlorophenyl)-1 H-imidazol-2-yl] -2-methylpropyl}isoxazole-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-5-methyl-lH-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2,4-dimetihyl-l,3-tbiazole-5-carboxamide; 30 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methyIpropyl}tetrahydrofuran-3-carboxamide; N 2-amino-N-(3-aminopropyl)-N- { (1R)-1 -[1 -benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl]-2-methyIpropyl}-l,3-thiazole-4-carboxamide; N4(lR)-1-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2J2-dimethylpropyl]-N-(lH-imidazol-4-ylmethyl)benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(2-hydroxypyridin-4-yl)methyl]benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)2,2-dimethylpropyl]-N-[(6-hydroxypyridin-3-yl)methyl]benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-(pyridin-3 -ylmethyl)benzamide; N^(lR)-l(l-ben2yM-phenyl4H4midazol-2-yl)2,2-dimethylpropyl]-N-[3-(cyclobutylamino)propyl]benzamide; N-[(lR)-1-(l-benzyl-4-phenyl4H-imidazol-2-yl>2,2-dimethylpropyl]-N-(pyrrolidin-3-ylmethyl)beazamide; N-(3-aininopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-6-methylnicotinamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[(cyclopropylmethyl)amino]propyl}ben2amide; N-[(lR)4-(l-benzyl-4-phenyl4H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-({[5-pyridin-3-yIoxy)-lH-indazol-3-yl]methyl}amino)propyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(5-methoxy-lH-indazol-3-yl)methyl]benzamide; N-[(lR)-1-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-{[(6-fluoro4H-indazol-3-yl)methyI]amino}propyl)ben2ainide; N-[(lR)-1-(l-benzyl-4-phenyl4H-iijiidazol-2-yl)-2,2-dimethylpropyl]-N-{[5-(pyridin-3-yloxy)4H-indazol-3-yl]methyl}benzainide; N-[(lR)-1-l-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-hydroxypropyl)benzamide; N-(3-aminopropyl)-N-[(lR)4-(l-benzyl-4-phenyl4H-imidazol-2-yl)-2,2-dbnethylpropyl]-1,5-dimethyl4H-pyrazole-3-carboxamide; N-[(lR)4-(l-ben2yl-4-phenyl4H-imidazol-2-yl)-2,2-dimetiiylpropyl]-N-[(3R)-3,5-diamino-5-oxopentyl]benzamide; 31 WO 2006/002236 PCT/US2005/022062 N- {3 -[(aminoacetyl)amino]propyl} -N-[( 1R)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethyIpropyl]benzamide; N-{2r[(aminoacetyl)amino]ethyl}-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-[(lR)4-(l-benzyl-4-phenyl-lH-iinidazoL-2-yl)-2-methylpropyl]-l,5-dim6thyl-N-(piperidin-3-ylmethyl)-lH-pyrazole-3-carboxamide; (2R)-N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}tetrahydrofuran-2-carboxamide; (2S)-N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}tetrahydrofuran-2-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-cholrophenyl)-lH-imidazol-2-yl]-2-methylpropyl}pyrazine-2-carboxamide; 3-{benzoyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]amino}propyl benzoate; N-{(lR)-l-[4-(3-chlorophenyl)-l-(3,5-difluorobenzyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-l,5-dimethyl-N-[(3R)Tpyrrolidin-3-ylmethyl]-lH-pyrazole-3-carboxamide; N-{(lR)-l-[4-(3-chlorophenyl)-l-(3,5-difluorobenzyl)-lH-iinidazol-2-yl]-2,2-dimethyIpropyl}-l,5-dimethyl-N-[(3S)-pyrrolidin-3-ylmethyl]-lH-pyra2X)le-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-I-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methyIpropyl}-l-methyl-3-(trifluoromethyl)-lH-pyrazole-4-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-5-chloro-l-methyl-lH-pyrazole-4-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chIorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-(dimethylamino)acetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(lH-imidazol-2-yl)propyI]benzamide; l-ben2yl-6-(l-benzyl-4-phenyl-lH-imidazol-2-yl)piperidin-2-one; l-benzyl-6-[l-(3-chIorobenzyl)-4-phenyl-lH-imidazol-2-yl]piperidin-2-one; N-(3-aminopropyl)-N-[(lR)-1 -(1 -benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-1,5-dimethyl- lH-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyMH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[(2-b.ydroxyethyl)amino]propyl} benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(cyclopropylamino)propyl]benzamide; N-(3-aminopropyl)-N-{(lR)-2-methyl-l-[4-phenyl-l-(l,3-thiazol-4-ylmethyl)-lH-imidazol-2-yl]propyl}benzamide; 32 WO 2006/002236 PCT/US2005/022062 N(3-aminopropyl-4-methyl-N-{(1R)-2-methyl-l-[4-phenyl-l-(1,3-thiazol-4-ylmethyl)4H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-2,4-difluoro-N-{(lR)-2-methyl-l-[4-phenyl-l-(l,3-thiazol-4-ykaethyl)-lH-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-6-chloro-N-{(lR)-2-methyl-l-[4-phenyl-l-(l,3-thiazol-4-ylmethyl)-lH-imidazol-2-yl]propyl}nicottinamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-pyridin-2-yl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-pyridin-2-yl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N[(lR)-l-(l-benzyl-4-pyridin-2-yl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2,4-difluorobenzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-pyridin-2-yl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-6-chloronicotinamide; N-(2-amino-3-hydroxypropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]benzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-pb.enyl-lH-imidazol-2-yl)-3-metib.ylbutyl]ben2amide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-3-methylbutyl]-4-methylbenzainide; N-(3-aminopropyl)-N-[(lR,2R)-l-(l-benzyl-4-phenyl-lH-iinidazol-2-yi)-2-methylbutyl]benzamide; N-(3-aminopropyl)-N-[(lR,2R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylbutyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(lR,2S)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylbutyl]benzamide; N-(3-aminopropyl)-N-[(lR,2S)-l-(l-benzyl-4-phenyl-lH-iniidazol-2-yl)-2-methylbutyl]-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chloropb.enyl)-lH-in3idazol-2-yl]-2-methylpropyl}-5-methylisoxazole-4-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chloropheiiyl>lH»im}dazol-2-yl3-2-methylpropyl}-2-(4-fluorophenoxy)acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl3-2-methylpropyl} -2-( 1 H-imidazol-1 -yl)acetamide; 33 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chloroplienyl)-lH-imidazol-2-yl]-2-methylpropyl} -2-morpholin-4-ylacetamide; [(3-{benzoyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yI)-2,2-dimethylpropyl]amino}propyl)amino]aceticacid; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-hydroxyacetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophen)4)-lH-imidazol-2-yl]-2-methyIpropyl} -2-methoxyacetamide; N-(3-aminopropyI)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxyacetamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyI)-lH-imidazol-2-yl]-2-methylpropyl} -1 -ethyl-3-metiiyl-1 H-pyrazole-5-carboxamide; ethyl [(3-{benzoyl[(lR)-l-(l-benzyl-4-phenyl-lH-iniidazol-2-yl)-252-dimethylpropyl]amino}propyl)amino]acetate; N-{3-[(2-amino-3-methylbutanoyl)amino]propyl}-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzaniide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}tetrahydro-2H-pyran-4-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-(metb.ylamino)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-propylbenzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-butylbenzamide; N-[(lR)-l [[(lR)-l-(l-benzyl4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl](butyl)amino](oxo)aceticacid; [[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dime1hylpropyl](propyl)amino](oxo)aceticacid; N-[(lR)-l-(l-ben2yl-4-phenyl~lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[2-(hydroxymethyl)piperidin-1 -yl]propyl}benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[bis(2-hydroxyethyl)amino]propyl}benzamide; 34 WO 2006/002236 PCT/US2005/022062 1 -(2-amino-1 -phenylethyl)-6-(l -benzyl-4-phenyl-1 H-imidazol-2-yI)piperidin-2-one; 6-(l-benzyl-4-phenyl-lH-imidazol-2-yl)piperidin-2-one; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyIpropyl]benzamide; N-Kl^-l-Cl-benzyl^-phenyl-lH-imidazol^-y^^^-dimethylpropyO-N-CS-lp-hydroxy-1 -(hydroxymethyl)ethyl]atnino}propyl)benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-{[2-(hydroxymethyl)phenyl]amino}propyl)benzamide; N-{(lR)-l-[i-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-N-piperidin-4-ylbenzamide; N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-N-(piperidin-3-ylmethyl)benzamide; 2-(3-amino-2-oxopyridin-l (2H)-yl)-N-[(l R)-l -(1 -ben2yl-4-phenyl- lH-imidazol-2-yl)-2,2-dimethylpropyl]acetamide; N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-metb.ylpropyl}-2-pyrroiidin-3-ylbenzamide; (lR,3S)-3-{[(2-aminoethyl)sulfonyl]amino}-N-[(lR)-l-(l-ben2yl-4-phenyHH-imidazol-2-yl)-2,2-dimethylpropyl]cyclohexanecarboxamide; (1 R,3 S)-3-[(aminoacetyl)amino]-N-[(l R)-l-(l-benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyI]cyclohexanecarboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyI-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-6-(trifluoromethyl)nicotinamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; (3R)-N-(3-aminopropyl)-N-{(lR)»l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}piperidine-3-carboxamide; (3S)-N-(3-aminopropyl)-N-{(lR)-l-[l-beDzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-mefthylpropyl}piperidine-3-carboxamide; N-(3-aininopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-(lH-l,2,4-triazol-l-yl)acetamide; [(5R)-1 -benzoyl-5-(l -benzyl-4-phenyl-1 H-imidazol-2-yl)pyrrolidin-2-yl]methylamine; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-irQidazol-2-yl]-2-methylpropyl} -2-(4H-1,2,4-triazol-4-yl)acetamide; 35 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)»l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -2,1,3 -benzothiadiazole-4-carboxamide; N-[(2S)-3-amino-2-hydroxyi)ropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-1,5-dimethyl-1 H-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l,5-dimethyl-N-[(2S)-morpholin-2-ylmethyl]-lH-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l,5-dimethyl-N-[(2R)-morpholin-2-ylmethyl]-lH-pyra2»le-3-carboxamide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethylpropyl]-1,5-dime&yl-lH-pyrazole-3-carboxamide; N-[(2S)-3-amino-2-hiydroxypropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-me1iioxyacetaniide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-pyrrolidin-3-ylben2amide; N-(3 -aminopropyl)-N- {(1R)-1 -[1 -benzyl-4-(3 -chlorophenyl)-1 H-imidazol-2-yl]-2-methylpropyl}-2-(lH-pyrazol-l-yl)acetamide; N-[(2R)-3-amino-2-jfluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimetb.ylpropyl]-l,5-dimethyl-lH-pyrazole-3-carboxamide; methyl 3-aminopropyl[(l R)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyI-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-(3-aminopropyl)-N-[(lR)-l -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-l ,2,4-triazol-l-yl)acetamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimeth.ylpropyl]-2-(4H-l,2,4-triazol-4-yl)acefamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxy-N-[(2S)-morpholin-2-ylmethyl]acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimet][iylpropyl]-2-methoxy-N-[(2R)-morpholin-2-ylmethyl]acetamide; N-(3-aminopropyl)-N-[(lS)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-hydroxy-2-methylpropyl]benzamide; 36 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy-N-[(2S)-morphoIin-2-yImethyl]acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy-N-[(2R)-morpholin-2-ylmethyl]acetemide; (2S)-N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yI)-2,2-dimethylpropyl]tetrahydrofturan-2-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chiorophenyl)-l-(3-cyanobenzyl)-lH-imidaz»l-2-yl]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(3-cyanobenzyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chloropheiiyl)-l-(3-methylbenzyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzarnide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyI)-l-(3-methylbenzyl)-lH-imidazol-2-yl]-2-methylpropyl}benzamide; ethyl 3-aminopropyl[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; neopentyl3-aminopropyl[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; isobutyl3-aminopropyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyljcarbamate; propyl3-aminopropyl[(lR)-l-(l-benzyl-4-p]ienyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-cyanoacetamide; N-[(lR)-l-(l-benzyl4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxy-N-[(3R)-pyrrolidiH-3-ylmethyl]acetamide; N-[(lR)4-(l-ben2yl4-phenyl4H-imidaral-2-yl)-2,2-dimethylpropyl]-2-methoxy-N-[(3S)-pyrrolidm-3-ylmetb.yl]acetamide; butyl 3-aminopropyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; N-[(lR)-1-(l-ben2yM-phenyl-lH-imidazol-2-yl)-2>dimetibiylpropyl]-2-hydroxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-[(lR)-l-(l-benzyl-4-pheny1H-imidazol-2-yl)-2,2-dime1Iiylpropyl]-N-[(3S)-pyrrolidin-3-ylmethyl]benzamide; 37 WO 2006/002236 PCT/US2005/022062 N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazx)l-l-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-beij2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(lR)-l-(l-beazyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S)-3,4-diamino-4-oxobutyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3R)-3,4-diamino-4-oxobutyl]benzamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; (2S)-2-amino-4-{benzoyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]amino}butanoic acid; N-[(2R)-3-ammo-2-fluoropropyl]-N-[(lR)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxyacetamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-252-dimeth.ylpropyl]-2-(lH-tetrazol-5-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyHH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S)-pyrrolidin-3-ylmetb.yl]-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S)-pyrrolidin-3-ylmethyl]-2-(2H-tetrazol-2-yl)acetamide; N4(lR)-l-(l-beozyl-4-phenyl4H-iinidazol-2-yl)-2,2-dimethylpropyl]-6-methyl-N-[(3S)-pyrrolidin-3-ylmethyl]nicotinaniide; N-(azetidin-3-ylmethyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3-yImethyl)benzamide; N-{(lR)-2,2-dimethyI-l-[l-(3-methylben2yl)-4-phenyl-lH-imidazol-2-yl]propyl}-N-(pyrrolidin-3-ylmethyl)benzamide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl3-2-hydroxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(methoxyamino)propyl]benzamide; 38 WO 2006/002236 PCT/US2005/022062 N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-2-methoxy-N-[(3S)-pyrrolidin-3-ylmethyi]acetamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-phe]iyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-2-methoxy-N-[(3R)-pyrrolidin-3-ylmeihyl]acetainide; N-(3-aininopropyl)-N-{(lR)-l-[l-(3-cyanoben2yl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}beBzatnide; N-(3-aminopropyl)-N-{(lR)-l -[1 -(3-cyanoben2yl)-4-phenyl-l H-imidazol-2-yl]-2,2-dimethylpropyl}-2-metiioxyacetamide; 2-hydroxy-N-{(lR)-l-[l-(3-hydtoxybenzyl)4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3-ylmethyl)acetamide; N-{(lR)-2>dimethyl-l-[l-(3-methylbenzyl)-4-phenyl-lH-iinida2»l-2-yl]propyl} -2-methoxy-N- [(3 S)-pyrrolidin-3-ylmethyl]acetamide; N-{(lR)-2,2-dimethyl-l-[l-(3-methylbenzyl)-4-phenyl-lH-iiiudazol-2-yl]propyl}-2-methoxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetainide; N-(3-aminopropyl)-N-{(lR)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-pheiiyl-lH-imidazol-2-yl]propyl}-2-methoxyacetamide; N-[(3S)-3-amino-4-hydroxybulyl]-N-[(lR)-l-(l-benzyI-4-phenyl-lH-imidazol-2-yl)-2,2-dimetiiylpropyl3-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-(3-amino-2-hydroxypropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-1 -yl)acetamide; N-(3-amino-2-hydroxypropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-1-l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l,5-dimethyl-N-[(3S)-pyrrolidin-3-ylmethyl3-1H-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-2,2-dimethyl-l-[l-(3-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}benzamide; N-(azetidin-3-ylmeihyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-(azetidin-3-ylmethyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxyacetamide; N-(azetidin-3-ylmethyl)-N-[(lR)-1-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-252-dimethylpropyl]-l,5-dimethyl-lH-pyrazole-3-carboxamide; 39 WO 2006/002236 PCT/US2005/022062 N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-dimethylpropyl-ClH-l^.S-triazol-l-yQacetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-ben2yl-4-plieiiyl-lH-imidazol-2-yl)-2s2-dimethylpropyl]-2-(2H-l,2,3-triazol-2-yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-beii2yl-4-pheiiyl-lH-imidazol-2-yl)-252-dimetb.ylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)4 N-[(3S)-3-amino-4-hydroxybutjrl]-N-[(lR)-l-(l-ben2yl-4-plienyl-lH-imidazol-2-yl)--dimethylpropyl-2-(lH-l,2,3-triazol-l-yl)acetamide;. N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-fluoropyrrolidin-3-yl)methyl]amine; N-[(lR)-1-(l-benzyl--phenyl-1H-imidazol-2-yl)-2,2-dimethyIpropyl]-N-{[(3S)-3-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetaDiide; N-[(lR)-1-(l-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2.dimethylpropyl]-N-{[(3R)-3-hydroxypyrrolidin-3-yl]methyl}-2-me1hoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyHH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-hydroxypyrrolidin-3-yl)methyl]-2-methoxyacetamide; N-(azetidin-3-ylmethyl)-N-[(1R)-l-(1-benzyl-4--phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-6-methylnicotinamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-fluoropyirolidta-3-yl]me1h.yl}rl,5-dimetb.34-lH-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-fluoropyrrolidin-3-yl)methyl]-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-[(lR)-1-(l-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-fluoropyrrolidin-3-yl]methyl}benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyi}benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-fluoropyrrolidin-3-yl)methyl]benzamide; N-(3-aminopropyl)-2-hydroxy-N-{(lR)-l-[l-(3-hydroxybenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}acetamide; 40 WO 2006/002236 PCT/US2005/022062 N-{(lR)-l-[l-(3-hydroxybenzyl)-4-phenyl-lH-imidazolr2-yl]~2,2-dimethylpropyl}-N-(pyrrolidin-3-ylmetiiyl)benzamide; N^3-aminopropyl)-N-{(lR)-2,2~dimethyl-l-[l-(3-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-{(lR)-2,2-dimethyl-l-[l-(3-methylbenzyl),4-phenyl-lH-imidazol-2-yl]propyl}-l,5-dimethyl-N-(pyiTolidin-3-yImethyl)-lH-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[I-(3-hydroxybenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-methoxybenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}benzaniide; N-(3 -aminopropyl)-2-methoxy-N- {(1 R)- 1 -[ 1 -(3-methoxybenzyl)-4-phenyl- 1H-imidazol-2-yl]-2,2-dimethylpropyl}acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-cyaiioben2yl)-4-phenyl-lH-iinidazol-2-yl]-2,2-dimethylpropyl}-2-b.ydroxyacetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-methoxybenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-l,5-dunethyl-lH-pyrazole-3-carboxamide; N-[(3S)-3-ammo-4-methoxybutyl]-N-[(lR)-l-(l-benzyl'4-phenyl-lH-imidazol-2-yI)-2,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l"(3-cyanobenzyl)~4-phenyl-lH-imidazol-2-yl]-2;2-dimethylpropyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-{(lR)-l-[l-(3-cyanoben2yl)-4-phenyl-lH-imidazol-2-yl]-2,2~dimethylpropyl}-l,5-dimetliyl-N-(pyrroIidin-3-ylmethyl)-lH-pyrazole-3-carboxamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyI-lH-imidazol-2-yl]-2,2-dimethylpropyl}-2-hydroxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimeHiylpropyl]-2-(lH-l,2s3-triazol-l-yl)acetamide; . N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-l,2,3-triazoI-2-yl)acetamide; N-[(lR)-l-(l-benzyl-4-plienyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-hydroxypyrro]idin-3-yl]metiiyl}benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2)2-dimethylpropyl]-N-{[(3R)-3-hydroxypyrrolidin-3-yl]methyl}benzamide; N-[(lR)-l-(l-benzyl-4-plienyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-hydroxypyrrolidin-3-yl)methyl]benzamide; N-[(lR)-l-(l-ben2yI-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-ethoxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; 41 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imida2X)l-2-yI)-2,2-dimethylpropyl]-2-ethoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl4H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-hydroxypyrrolidin-3-yl]methyl}-l,5-diinethyl-lH-pyrazole-3-carboxamide; N-[(lR)-l-(I-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-hydroxypyrrolidin-3-yl]methyl}-1,5-dimethyl-l H-pyrazole-3-carboxamide; N4(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yI)-2,2-dimethylpropyl]-N-[(3-hydroxypyrrolidin-3-yl)methyl]-l,5-dimethyl-lH-pyrazole-3-carboxainide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lS)-l-(l-benzyI-4-phenyl-lH-imidazol-2-yl)-2-hydroxy-2-methylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-[(2S)-3-aniino-2-fluoropropyl3-N-[(lR)-l[l-benzyl-4-(3-fluorophenyl-lH-imidazol-2-yl)-2-hydroxy-2-methylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N4(2S)-3-amino-2-fluoropropyl]-N-{(lR)-l-[l-berizyl-4-(3-fluorophenyl)-lH-iimdazol-2-yl]-2,2-4imethylpropyl}-2-(lH-tetrazol-l-yl)acetarnide; N-[(2S)-3-amino-2-fluoropropyl]-N-{(lR)-l-[l-ben2yl-4-(3-fluorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-2-(2H4etra2»l4-yl)acetamide; N-[(2S)-3-amino-2-(hydroxymetIiyl)propyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N'-metiiylethanediamide; N4(2R)-3-amino-2-(hydroxymethyl)propyl]-N-[(lR)-l-(l-beiizyl-4-pheiiyl-lH-imidazol-2-yl)-2,2-dimetliylpropyl]-N'-metfiylethanediamide; N4(3R)-3-amino-4-b.ydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3R)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(l H-tetrazol-1 -yl)acetamide; N-[(3R)-3-amlno-4-hydroxybutyl]-N-[(lR>l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-1-(l-benzyl-4-pheny]-lH-imidazoI-2-yl)-2,2-dime1hylpropyl]-N-{[(3S)-3-fluoropyrrolidin-3-yl]methyl}-2-metlidxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyI-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyl}-2-metiioxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimetbylpropyl]-N-{[(3R,4R)-4-hydroxypyrrolidin-3 -yl]methyl} -2-methoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yI)-2,2-dimethylpropyl]-N-{[(3S,4S)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; .N-[(lR)-l-(l-benzyl-4-phenyl~lH-imidazol-2-yl)-2,2-dimet]iylpropyl]-N-{[(3R,4R)-4-hydroxypyrrolidin-3-yl]methyl}benzamide; 42 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S,4S)-4-liydroxypyrrolidin-3-yl]methyl}benzamide; N4(3S)-3-ardno-4-hydroxybutyl]-N-{(lR)-l-[l-benzyl-4-(3-fluorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl} -2-(l H-tetrazol-1 -yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyt]-N-{(lR)-l-[l-benzyl-4-(3-fluorophenyl)-lH-imidazol-2-yl]-2,2-dimethyIpropyl}-2-(2H-tetrazol-2-yl)acetamide; N4(3S)-3-amino-4-methoxybutyl]-N-[(lR)-l-(l-beiizyl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-{(lR)-l-[l-ben2yl-4-(3-fluorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-2-metiioxyacetamide; N4[(lR)-1-(l-benzyl-4-phenyl-1H-imidazoI-2-yl)2,2-dimethylpropyl]-N-{[(3S)-3-fluoropyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)4-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyl}-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-1-(l-benzyl-phenyl4H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S,4S)-4-hydroxypyrrolidin-3-yl]methyI}-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-1-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S,4S)-4-hydroxypyrrolidin-3ryl]methyl}-2-(2H-tetrazol-2-yl)acetaraide; N4(lR)-1(l-benzyl-4-phenyl4H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetaiiiide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-1-(l-benzyl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethylpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(lR)-l-(l-ben2yl-4-pheayl-lH-imida2X)l-2-yl)-2^-dimeth.ylpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}benzamide; N-[(2R)-3-aminoo-2-fluoropropyl]-N-[(lR)4-(l-ben2yl-4-phenyi4H-imidazol-2-yl)-2,2-dimethylpropyl]-2-(5-methyl-2H-tetrazol-2-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl4H-imidazol-2-yl)-2,2-dimethylpropyl]-2-(5-methyl4H-tetrazol4-yl)acetamide; N-[(lR)-1-(l-benzyl-4-phenyl-1H-imidazol-2.yl)-2,2-dimethylpropyl]-N-{[(3R)-3-hydroxypyrrolidin-3-yl]methyl}-2-(lH-tetrazol-l-yl)acetamide; 43 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-hydroxypyrrolidin-3-yl]metiiyl}-2-(lH-tetrazol-l-yl)acetainide; (5S)-3-[(lR)-1-(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-1 -oxa-3,7-diazaspiro[4.4]nonan-2-one; (5R)-3-[(1R)-1-(1-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-!-oxa-3,7-diazaspiro[4.4]nonan-2-one; N-[(2S,3R)-3-amino-2-fluoro-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3S)-3-amino-4-fluorobutyl]-N-[(lR)-l-(l-ben2yl-4-pheQyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3R)-3-amino-4-fluorobutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{ [(3R,4S)-4-hydroxypyrrolidin-3-yl]metb.yl} -2-methoxyacetamide; N4(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(lR)-l N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-(2,5-dihydro-lH-pyrrol-3-yImethyl)-2-methoxyacetamide; N-((R)-3-Atnino-2-fluoro-propyl)-N-[(R)-l-(l-ben2yl-4-pyrazin-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl3-2-methoxy-acetamide; N-((^)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-ben2yl-4-(3-methoxy-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-ethoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(3-methoxy-phenyl)-lH-imidazol-2-yl]r2,2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-ftiran-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-1 -(1 -benzyl-4-pyrazin-2-yl-1 H-imidazol-2-yl)-2,2-dimethyl-propyl]-amide; N-((R)0-Amino-2-fluoro-propyl)-N-[(R)-l-(l-ben2yl-4-pyrazin-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-ethoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-benzyl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethyl-propyl]-2-ethoxy-acetaraide; (S)-Tetrahydro-furan-2-carboxylicacid((R)-3-amino-2-fluoro-propyl)-[(R)-l-(l-benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2 dimethyl-propyl]-amide; N-((S)-3-Amino-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyl-l-pyridin-3-ylmethyl-1H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; 44 WO 2006/002236 PCT/US2005/022062 N-((R)-3-Amino-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyl-l-pyridin-3-ylmethyl-lH-imidazoI-2-yl)-propyl]-2-methoxy-acetamide; N-((S)-3-Ainino-4-methoxy-butyl)-N-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazoI-2-yl3-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)4-[l-benzyl-4-(4-cyano-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(4-methoxy-phenyl)-lH-imidazol-2-yl]-2,2-dimetliyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(2-fluoro.benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetaiiiide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-me11ioxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(3-chloro-benzyl)-4-phenyl-lH-imidazoI-2-yi]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(3-cyano-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-l-[4-phenyl-l-(tetrahydro-pyran-4-ylmethyl)-lH-imidazol-2-yi]-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid((R)-3-amino-2-fluoro-propyl)~{(R)-l-[l-benzyl-(3-fluoro-phenyl)-lH-iimdazol-2-yi]-2,2-dimethyl-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-l-[l -benzyl-4-(2-methoxy-phenyl)-lH-iniidazol-2-yl]-2,2-dimethyl-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylicacid((R)-3-amino-2-fluoro-propyl)-{(R)-l-[l-benzyl-4-(3-trifluoromethyl-phenyl)-lH-imida2»i-2-yl]-2,2-dime1feyl-propyl}-am (S)-Tetrahydro-furan-2-carboxyHcacid((R)-3-aniino-2-fluoro-propyl)-{(R)-l-[l-benzyl-4-(3-bromo-phenyl)-lH-imidazol-2-yl]-2,2-dimetb.yl-propyl}-amide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)4-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethiyl-propyl}-2-methoxy-acetamide; N N-((R)-3-Anaino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(3-trifluoromethyl-pheaiyI)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amno-2-fluoro-propyl)-N-{(R)-l-[l-ben2yl-4-(3-bromo-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N 45 WO 2006/002236 PCT/US2005/022062 N-((S)-3-Amino-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyI-l-pyridin-4-ylmethyl-1 H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; .N-((R)-3-Amino4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyl-l-pyridin-4-ylmethyl-lH-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-2,2-dimethyl-l-[l-(5-methyl-isoxazol-3-ylmethyl)-4-phenyl-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(U)-2>diinethyl-l-[l-(5-methyl-isoxazol-3-ylmethyl)-4-phenyl-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N N-((R)-3-Amino-4-fluoro-butyl)-N4(R)-2,2-diinethyl-l-(4-phenyl-l-pyridin-2-ylmethyl-1 H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-ben2yl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N N (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-1 -(1 -benzyl-5-chloro-4-phenyl-lH-imidazol-2-yl)-2,2-dimetiiyl-propyl]-amide; N-((R)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-benzyl-5-chloro-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid((R)-3-amino-2-£luoro-propyl)-[(R)-l-(l-bea2yl-4-thiazol-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-amide; N-((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-l-[4-phenyl-l-(5-trifluoromethyl-furan-2-ylme1hyl)-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-l-[l-(5-methyl-isoxazol-3-ylmethyl)-4-phenyl-lH-imidazol-2-yl]-propDyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid((S)-3-amino-2-fluoro-propyl)-{(R)-2,2-dimethyl-l-[l-(5-methyl-isoxazol-3-ylmethyl)-4-phenyl-lH-iniidazol-2-yl]-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid((S)-3-amino-2-fluoro-propyl)-{(R)-2,2-dimethyl-1-[4-phenyl-1 -(5-trifluoromethyl-furan-2-ylmethyl)-1H-imidazol-2-yl]-propyl} -amide; N-((S)-3-Amino-4-methoxy-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-4-hydroxy-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; 46 WO 2006/002236 PCT/US2005/022062 N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(2,5-difluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)~N-{(R)-l-[l-(2,5-difluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(4-fluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-2-methoxy-N-{(R)-l-[l-(3-methoxy-ben2yl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-l-[l-(2-methyl-ben2yl)-4-phenyl-1H-imidazol-2-yl]-propyl} -2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-l-[l-(3-methyl-beii2yl)-4-phenyl-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-diinetliyl-l-[l-(3-methyl-benzyl)-4-phenyl-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N-[(R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-acetamide; N-((S)-3-Amino-2-fluoro-propyl>N-[(R)-l-(l-benzyl-lH-imidazol-2-yl)-2,2-dimetiiyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid((S)-3-amino-2-fluoro-propyl)-[(R)-l-(l-benzyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-amide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-beiizyl-4-thiazol-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}~2-methoxy-acetamide; N-[2-(l-Amino-cyclopropyl)-ethyI]-N-[(R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid [2-(l-amino-cyclopropyl)-ethyl]-[(R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-amide; [2-(l-Amino-cyclopropyl)-e1hyl]-[(R)-l-(l-benzyl-4-phenyl-lH"imidazol-2-yl)-2,2-dimethyl-propyl]-carbamic acid methyl ester; N-[2-(l-Amino-cyclopropyl)-ethyl]-N-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-metiioxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid[2-(l-amino-cyclopropyl)-ethyl]-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; 47 WO 2006/002236 PCT/US2005/022062 N-(3-Amino-propyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-metlioxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-ben2yl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-metiioxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-ben2yl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-(3 - Amino-propyl)-N- {1 -[1 -(3 -fluoro-benzyl)-4-(3-fluoro-phenyl)-l H-imidazol-2-yl]-l-methyl-ethyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N-{(R)"l-[l-(3-fluoro-ben2yl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-fiiran-2-carboxylicacid((S)-3-amino-4-fluoro-butyl)-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)4H-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-benzyl-5-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-ben2yl-4-(3-chloro-phenyl)-lH-imidazol-2-yl]-2-methyl-propyl}-2-methoxy-aceamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[4-(3-chloro-phenyl)-l-(3-fluoro-ben2yl)-lH-imidazol-2-yl]-2-methyl-propyl}-2-methoxy-acetamidej N-(3-Amino-4-fluoro-butyl)-N-{l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-1 -methyl-ethyl}-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; N-((R)-3-Amino-4-fluoro-butyI)-N-{(R)-l-[l-(3-fluoro-ben2yl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; (S)-Tetrahydro-fiiran-2-carboxylicacid((S)-3-amino-2-fluoro-propyl)-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (R)-9-{(R)4-[l-(3-Fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-ylJ-2,2-dimefliyl-propyl}-6-oxa-2,9-diaza-spiro[4.5]decan-8-one; (3-Amino-4-fluoro-butyl)-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; N-((S)-3-Amino-4-fluoro-bu1yl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-formatnide; N-((R)-3-Amino-4-fluofo-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-formamide; 48 WO 2006/002236 PCT/US2005/022062 N-(3-Dimethlamino-propyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-1 H-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methoxy-acetamide; N-((S)-3-Amino-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-ylJ-2,2-dimeihyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(6-amino-pyridin-2-ylmethyl)-4-(3-fluoro-phenyl)-1 H-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methoxy-acetamide; . N-((R)-3-Ammo4-fluoro-butyl)-N-{(R)-141 N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[4-(3-fluoro-phenyl)-l-(3-hydroxy-benzyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl]-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1 -[4-(3-fluoro-phenyl)-1 -(3-hydroxy-benzyl)-lH-imxdazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Ammo-4-fluoro-butyl)-N-[(R)-l-(l-benzyl-4-thiazol-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N-{(R)-l-[l-(3-Fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methoxy-N-(3-methylamino-propyl)-acetamide; N-(3-Amino-propyl)-N-{(R)-1 -[1-benzyl-4-(2,5-difluoro-phenyl)- lH-imidazoI-2-yI]-2,2-dimethyl-propyl} -acetamide; (3-Amino-propyl)-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; (S)-Tetrahydro-furan-2-carboxylicacid(3-amino-propyl)-{(R)-l-[l-beozyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-diniethyl-propyl}-amide; 3-[{(R)-l-[l-(3-Fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-(2-methoxy-acetyl)-amino]-propionamide; N-(3-Amino-propyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methanesulfonyl-acetamide; N-((S)-3-Amino-4-methoxy-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylie acid ((S)-3-amino-4-fluoro-butyl)-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yI]-2,2-dimethyl-propyl}-amide; (R)-l-[l-Benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propylamine; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3 -amino-4-methoxy~butyl)-{(R)-1 -[l-ben2yl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; 49 WO 2006/002236 PCT/US2005/022062 N-((R)-3-Amino-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-l-[l-Benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-N-(l H-[l ,2,3]triazol-4-ylmethyl)-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; ((S)-3-Amino-4-fluoro-butyl)-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; {(R)-l-[l-Benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid tert-butyl ester; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-2-(4-fluorophenoxy)acetamide; and pharmaceutically acceptable salts thereof. [0058] 23. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier. [0059] 24. The composition of claim 23 further comprising at least one additional agent for the treatment of cancer. [0060] 25. The composition of claim 23, wherein the additional agent for the treatment of cancer is selected from the group consisting of irinotecan, topotecan, gemcitabine, imatinib, trastuzumab, 5-fiuorouracil, leucovorin, carboplatin, cisplatin, docetaxel, paclitaxel, tezacitabine, cyclophosphamide, vinca alkaloids, anthracyclines, rituximab, and trastuzumab. [0061] 26. A method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a composition of claim 23. 50 WO 2006/002236 PCT/US2005/022062 [0062] 27. The method of claim 26, wherein the disorder is a cellular proliferative disease. [0063] 28. The method of claim 27, wherein the cellular proliferative disease is cancer. [0064] 29. The method of claim 28, wherein the cancer is selected from the group consisting of lung and bronchus; prostate; breast; pancreas; colon and rectum; thyroid; stomach; liver and intrahepatic bile duct; kidney and renal pelvis; urinary bladder; uterine corpus; uterine cervix; ovary; multiple myeloma; esophagus; acute myelogenous leukemia; chronic myelognous leukemia; lymphocytic leukemia; myeloid leukemia; brain; oral cavity and pharynx; larynx; small intestine; non-hodgkin lymphoma; melanoma; and villous colon adenoma. [0065] 30. The method of claim 29 further comprising administering to the mammalian patient one additional agent for the treatment of cancer. [0066] 31. The method of claim 30, wherein the additional agent for the treatment of cancer is selected from the group consisting of irinotecan, topotecan, gemcitabine, imatinib, trastuzumab, 5-fluorouracil, leucovorin, carboplatin, cisplatin, docetaxel, paclitaxel, tezacitabine, cyclophosphamide, vinca alkaloids, anthracyclines, rituximab, and trastuzumab. [0067] 32, A method for inhibiting KSP kinesin in a mammalian patient, wherein said method comprises administering to the patient an effective KSP-inhibiting amount of a compound of claim 1. [0068] 33. Use of the composition of claim 23 in the manufacture of a medicament for the treatment of cancer. 51 WO 2006/002236 PCT/US2005/022062 Alternate Embodiments [0069] In an alternate embodiment, the invention is directed to compounds represented by the following formula: wherein: R1 is aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, Q to Ce alkyl, optionally substituted with hydroxy or halo; R2 is selected from the group consisting of hydrogen, C1 to C6 alkyl, and aryl; R3 is -X-A, wherein A is selected from the group consisting of alkyl, substituted alkyl, aryl, heteroaryl, heterocyclic, and cycloalkyl, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of C1 to C6 alkyl, C1 to C6 substituted,alkyl, C1 to C6 alkoxy, C1 to C6 substituted alkoxy, amino, substituted amino, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, and nitro and X is selected from the group consisting of-C(O)-, -C(S)-, -S(O)-, -S(O)2-, and -S(O)2-NR, where R is hydrogen or C1 to C6 alkyl; R1 and R3, together with the carbon atom attached to R1 and the nitrogen atom attached to R3 form a heterocyclic or substituted heterocyclic group; R4 is selected from the group consisting of-alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylenejp-nitrogen-containing aryl, -[alkylene]p-nitrogen-containing substituted aryl, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl and -[alkylene]p-NRaRb wherein p is an integer from 0 to 1, 52 WO 2006/002236 PCT/US2005/022062 alkylene is a C1 to C6 straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo and halo; Ra and Rb are independently selected from the group consisting of hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl and substituted cycloalkyl or when Ra is hydrogen, Rb is hydroxy, alkoxy or substituted alkoxy; R5 is selected from the group consisting of L-A', wherein L is selected from the group consisting of-S(O)q- where q is one or two, and C1 to C5 alkylene, optionally substituted with hydroxy, halo, or acylamino; and A' is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl and substituted cycloalkyl; and one of either R6 or R7 is selected from the group consisting of aryl and heteroaryl, wherein aryl and heteroaryl may be optionally substituted with -(R8)m where R8 is as defined herein and m is an integer from 0 to 3, and the other of R6 and R7 is hydrogen or C1 to C6 alkyl; R8 is selected from the group consisting of C1 to C6 alkyl, C2 to C6 alkenyl, C2 to C6 alkynyl, -CF3, C1 to C6 alkoxy, halo, and hydroxy; or pharmaceutically acceptable salts, esters or prodrugs thereof. Representative Compounds of the Invention [0070] Specific compounds within the scope of this invention are exemplified in Tables 1,2, and 3 in the experimental section. Methods and Compositions of the Invention [0071] Also provided is a composition comprising a compound of formulae I- VII (including mixtures thereof) and a pharmaceutically acceptable excipient or carrier. [0072] In another aspect, the present invention provides methods of treating a mammalian patient suffering from a disorder mediated, at least in part, by KSP. Thus, the 53 WO 2006/002236 PCT/US2005/022062 present invention provides methods of treating a mammalian patient in need of such treatment comprising administering to the patient a therapeutically effective amount of a compound of formulae I-VII (including mixtures thereof) either alone or in combination with other anticancer agents. DETAILED DESCRIPTION OF INVENTION A. Definitions and Overview [0073] As discussed above, the present invention is directed to new substituted imidazole compounds. [0074] It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention. It must be noted that as used herein and in the claims, the singular forms "a," "and" and "the" include plural referents unless the context clearly dictates otherwise. In this specification and in the claims which follow, reference will be made to a number of terms which shall be defined to have the following meanings: [0075] As used herein, "alkyl" refers to monovalent saturated aliphatic hydrocarbyl groups having from 1 to 6 carbon atoms and more preferably 1 to 3 carbon atoms. This term is exemplified by groups such as methyl, ethyl, n-propyl, iso-propyl, n-butyl, t-butyl, n-pentyl and the like. [0076] The term "linear alkyl" refers to an alkyl group that is not branched. [0077] "Substituted alkyl" refers to an alkyl group having from 1 to 3, and preferably 1 to 2, substituents selected from the group consisting of alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aryl, substituted aryl, aryloxy, 54 WO 2006/002236 PCT/US2005/022062 substituted aryloxy, cyano, halogen, hydroxyl, nitro, carboxyl, carboxyl esters, cycloalkyl, substituted cycloalkyl, spirocycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, -SO2alkyl, -SO2-substituted alkyl wherein said substituents are defined herein. [0078] "Alkylene" refers to divalent saturated aliphatic hydrocarbyl groups preferably having from 1 to 5 and more preferably 1 to 3 carbon atoms which are either straight-chained or branched. This term is exemplified by groups such as methylene (-CH2-), ethylene (-CH2CH2-), n-propylene (-CH2CH2CH2-), iso-propylene (-CH2CH(CH3)-) and the like. [0079] "Alkoxy" refers to the group "alkyl-O-" which includes, by way of example, methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, t-butoxy, sec-butoxy, n-pentoxy and the like. [0080] "Substituted alkoxy" refers to the group "substituted alkyl-O-". [0081] "Acyl" refers to the groups H-C(O)-, alkyl-C(O)-, substituted alkyl-C(O)-, alkenyl-C(O)-, substituted alkenyl-C(O)-, alkynyl-C(O)-s substituted alkynyl-C(O)-cycloalkyl-C(O)-, substituted cycloalkyl-C(O)-, aryl-C(O)-, substituted aryl-C(O)-, heteroaryl-C(O)-, substituted heteroaryl-C(O)-, heterocyclic-C(O)-, and substituted heterocyclic-C(O)-, wherein alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein. [0082] "Aminoacyl" refers to the group -C(O)NRR where each R is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted 55 WO 2006/002236 PCT/US2005/022062 cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic and where each R is joined to form together with the nitrogen atom a heterocyclic or substituted heterocyclic ring wherein alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl,. substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein. [0083] "Acyloxy" refers to the groups alkyl-C(O)O-,substituted alkyl-C(O)O-, alkenyl-C(O)O-, substituted alkenyl-C(0)O, alkynyl-C(O)O-, substituted alkynyl-C(O)O-, aryl-C(O)O-, substituted aryl-C(O)O-, cycloalkyl-C(O)O-, substituted cycloalkyl-C(O)O-, heteroaryl-C(O)O-, substituted heteroaryl-C(O)O-, heterocyclic-C(O)O-, and substituted heterocyclic-C(O)O- wherein alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein. [0084] "Oxyacyl" or "carboxyl ester" refers to the groups -C(O)O-alkyl, substituted -C(O)O-alkyl, -C(O)O-alkenyl, -C(O)O-substituted alkenyl, -C(O)O-alkynyl, -C(O)O-substituted alkynyl, -C(O)O-aryl, -C(O)O-substituted aryl, -C(O)O-cycloalkyl, -C(O)0-substituted cycloalkyl, -C(O)O-heteroaryl, -C(O)O-substituted heteroaryl, -C(O)O-heterocyclic, and -C(O)O-substituted heterocyclic wherein alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein. 56 WO 2006/002236 PCT/US2005/022062 [0085] "Alkenyl" refers to alkenyl groups having from 2 to 6 carbon atoms and preferably 2 to 4 carbon atoms and having at least 1 and preferably from 1 to 2 sites of alkenyl unsaturation. Such groups are exemplified by vinyl, allyl, but-3-en-l-yl, and the like. [0086] "Substituted alkenyl" refers to alkenyl groups having from 1 to 3 substituents, and preferably 1 to 2 substituents, selected from the group consisting of alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aryl, substituted aryl, aryloxy, substituted aryloxy, cyano, halogen, hydroxyl, nitro, carboxyl, carboxyl esters, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic with the proviso that any hydroxyl substitution is not attached to a vinyl (unsaturated) carbon atom. [0087] "Alkynyl" refers to alkynyl groups having from 2 to 6 carbon atoms and preferably 2 to 3 carbon atoms and having at least 1 and preferably from 1 to 2 sites of alkynyl unsaturation. [0088] "Substituted alkynyl" refers to alkynyl groups having from 1 to 3 substituents, and preferably 1 to 2 substituents, selected from the group consisting of alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aryl, substituted aryl, aryloxy, substituted aryloxy, cyano, halogen, hydroxyl, nitro, carboxyl, carboxyl esters, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic with the proviso that any hydroxyl substitution is not attached to an acetylenic carbon atom. [0089] "Amino" refers to the group -NH2. [0090] "Cyano" refers to the group -CN. 57 WO 2006/002236 PCT/US2005/022062 [0091J "Substituted amino" refers to the group -NR'R" where R' and R" are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, -SO2-alkyl, -SO2-substituted alkyl, and where R' and R" are joined, together with the nitrogen bound thereto to form a heterocyclic or substituted heterocyclic group provided that R' and R" are both not hydrogen. When R' is hydrogen and R" is alkyl, the substituted amino group is sometimes referred to herein as alkylamino. When R' and R" are alkyl, the substituted amino group is sometimes referred to herein as dialkylamino. When referring to a monosubstituted amino, it is meant that either R' or R" is hydrogen but not both. When referring to a disubstituted amino, it is meant that neither R' or R" is hydrogen. [0092] "Acylamino" refers to the groups -NRC(Q)alkyl, -NRC(O)substituted alkyl, -NRC(O)cycloalkyl, -NRC(O)substituted cycloalkyl, -NRC(O)alkenyl, -NRC(O)substituted alkenyl, -NRC(O)alkynyl, -NRC(O)substituted alkynyl, -NRC(O)aryl, -NRC(O)substituted aryl, -NRC(0)heteroaryl, -NRC(O)substituted heteroaryl, -NRC(0)heterocyclic, and -NRC(0)substituted heterocyclic where R is hydrogen or alkyl and wherein alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic are as defined herein. [0093] "Nitro" refers to the group -NO2. [0094] "Aryl" or "Ar" refers to a monovalent aromatic carbocyclic group of from 6 to 14 carbon atoms having a single ring (e.g., phenyl) or multiple condensed rings (e.g., 58 WO 2006/002236 PCT/US2005/022062 naphthyl or anthryl) which condensed rings may or may not be aromatic (e.g., 2-benzoxazolinone, 2H-l,4-benzoxazin-3(4H)-one-7-yl, and the like) provided that the point of attachment is at an aromatic carbon atom. Preferred aryls include phenyl and naphthyl. [0095] "Substituted aryl" refers to aryl groups which are substituted with from 1 to 3 substituents, and preferably 1 to 2 substituents, selected from the group consisting of hydroxy, acyl, acylamino, acyloxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, substituted amino, aminoacyl, aryl, substituted aryl, aryloxy, substituted aryloxy, carboxyl, carboxyl esters, cyano, thiol, alkylthio, substituted alkylthio, arylthio, substituted arylthio, heteroarylthio, substituted heteroarylthio, cycloalkylthio, substituted cycloalkylthio, heterocyclicthio, substituted heterocyclictbio, cycloalkyl, substituted cycloalkyl, halo, nitro, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, amino sulfonyl (NH2-SO2-), and substituted amino sulfonyl. [0096] "Aryloxy" refers to the group aryl-O- that includes, by way of example, phenoxy, naphthoxy, and the like. [0097] "Substituted aryloxy" refers to substituted aryl-O- groups. [0098] "Carboxyl" refers to -COOH or salts thereof. [0099] "Cycloalkyl" refers to cyclic alkyl groups of from 3 to 10 carbon atoms having single or multiple cyclic rings including, by way of example, adamantyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclooctyl and the like. 59 WO 2006/002236 PCT/US2005/022062 [0100] "Spirocycloalkyl" refers to cyclic groups from 3 to 10 carbon atoms having a cycloalkyl ring with a spiro union (the union formed by a single atom which is the only common member of the rings) as exemplified by the following structure: [0101] "Substituted cycloalkyl" refers to a cycloalkyl group, having from 1 to 5 substituents selected from the group consisting of alkyl, substituted alkyl, oxo (=O), thioxo (=S), alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminoacyl, aryl, substituted aryl, aryloxy, substituted aryloxy, cyano, halogen, hydroxyl, nitro, carboxyl, carboxyl esters, cycloalkyl, substituted cycloalkyl, heteroaryi, substituted heteroaryl, heterocyclic, and substituted heterocyclic. [0102] "Halo" or "halogen" refers to fluoro, chloro, bromo and iodo and preferably is fluoro or chloro. [0103] "Hydroxy" refers to the group -OH. [0104] "Heteroaryl" refers to an aromatic group of from 1 to 10 carbon atoms and 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur within the ring. Such heteroaryl groups can have a single ring (e.g., pyridinyl or furyl) or multiple condensed rings (e.g., indolizinyl or benzothienyl) wherein the condensed rings may or may not be aromatic and/or contain a heteroatom provided that the point of attachment is through an atom of the aromatic heteroaryl group. In one embodiment, the nitrogen and/or the sulfur ring atom(s) of the heteroaryl gropu are optionally oxidized to provide for the N-oxide (N®O) sulfinyl, or 60 WO 2006/002236 PCT/US2005/022062 sulfonyl moieties. Preferred heteroaryls include pyridinyl, pyrrolyl, indolyl, thiophenyl, and furanyl. [0105] "Substituted heteroaryl" refers to heteroaryl groups that are substituted with from 1 to 3 substituents selected from the same group of substituents defined for substituted aryl. [0106] 'Nitrogen-containing heteroaryl" and "nitrogen-containing substituted heteroaryl" refers to heteroaryl groups and substituted heteroaryl groups comprising at least one nitrogen ring atom and optionally comprising other non-nitrogen hetero ring atoms such as sulfur, oxygen and the like. [0107] "Heteroaryloxy" refers to the group -O-heteroaryl and "substituted heteroaryloxy" refers to the group -O-substituted heteroaryl wherein heteroaryl and substituted heteroaryl are as defined herein. [0108] "Heterocycle" or "heterocyclic" or "heterocycloalkyl" or "heterocyclyl" refers to a saturated or unsaturated group having a single ring or multiple condensed rings, including fused bridged and spiro ring systems, from 1 to 10 carbon atoms and from 1 to 4 hetero atoms selected-from the group consisting of nitrogen, sulfur or oxygen within the ring wherein, in fused ring systems, one or more the rings can be cycloalkyl, aryl or heteroaryl provided that the point of attachment is through the heterocyclic ring. In one embodiment, the nitrogen and/or sulfur atom(s) of the heterocycylic group are optionally oxidized to provide for the N-oxide, sulfmyl, sulfonyl moieties. 61 WO 2006/002236 PCT/US2005/022062 [0109] "Substituted heterocyclic" or "substituted heterocycloalkyl" or "substituted heterocyclyl" refers to heterocyclyl groups that are substituted with from 1 to 3 of the same substituents as defined for substituted cycloalkyl. [0110] Examples of heterocyclyls and heteroaryls include, but are not limited to, azetidine, pyrrole, imidazole, pyrazole, pyridine, pyrazine, pyrimidine, pyridazine, indoli2dne, isoindole, indole, dihydroindole, indazole, purine, quinolizine, isoquinoline, quinoline, phthalazine, naphthylpyridine, quinoxaline, quinazoline, cinnoline, pteridine, carbazole, carboline, phenanthridine, acridine, phenanthroline, isothiazole, phenazine, isoxazole, phenoxazine, phenothiazine, imidazolidine, imidazoline, piperidine, piperazine, indoline, phthalimide, 1,2,3,4-tetrahydroisoquinoline, 4,5,6,7-tetrahydrobenzo[b]tbiophene, thiazole, thiazolidine, thiophene, benzo[b]thiophene, morpholinyl, thiomorpholinyl (also referred to as thiamorpholinyl), 1,1-dioxothiomorpholinyl, piperidinyl, pyrrolidine, tetrahydrofuranyl, and the like. [0111] "Nitrogen-containing heterocyclic" and "nitrogen-containing substituted heterocyclic" refers to heterocyclic groups and substituted heterocyclic groups comprising at least one nitrogen ring atom and optionally comprising other non-nitrogen hetero ring atoms such as sulfur, oxygen and the like. [0112] "Thiol" refers to the group -SH. [0113] "Alkylthio" or "thioalkoxy" refers to the group -S-alkyl. [0114] "Substituted alkylthio" or "substituted thioalkoxy" refers to the group -S-substituted alkyl. [0115] "Aryltbio" refers to the group -S-aryl, where aryl is defined above. 62 WO 2006/002236 PCT/US2005/022062 [0116] "Substituted arylthio" refers to the group -S-substituted aryl, where substituted aryl is defined above. [0117] "Heteroarylthio" refers to the group -S-heteroaryl, where heteroaryl is as defined above. [0118] "Substituted heteroarylthio" refers to the group -S-substituted heteroaryl, where substituted heteroaryl is defined above. [0119] "Heterocyclicthio" refers to the group -S-heterocyclic and "substituted heterocyclicthio" refers to the group -S-substituted heterocyclic, where heterocyclic and substituted heterocyclic are as defined above. [0120] "Heterocyclyloxy" refers to the group heterocyclyl-O- and "substituted heterocyclyloxy refers to the group substituted heterocyclyl-O- where heterocyclyl and substituted heterocyclyl are as defined above. [0121] "Cycloalkylthio" refers to the group -S-cycloalkyl and "substituted cycloalkylthio" refers to the group -S-substituted cycloalkyl, where cycloalkyl and substituted cycloalkyl are as defined above. [0122] "Biological activity" as used herein refers to an inhibition concentration when tested in at least one of the assays outlined in Example 20-27. [0123] As used herein, the term "pharmaceutically acceptable salts" refers to the nontoxic acid or alkaline earth metal salts of the compounds of formulae I-VII. These salts can be prepared in situ during the final isolation and purification of the compounds of formulae I-VII, or by separately reacting the base or acid functions with a suitable organic or inorganic acid or base, respectively. Representative salts include, but are not limited to, the following: acetate, 63 WO 2006/002236 PCT/US2005/022062 adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfotiate, digluconate, cyclopentanepropionate, dodecylsulfate, ethanesulfonate,-glucoheptanoate, glycerophosphate, hemi-sulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxyethanesulfonate, lactate, maleate, methanesulfonate, nicotinate, 2-napth-alenesulfonate, oxalate, pamoate, pectinate, persulfate, 3-phenylproionate, picrate, pivalate, propionate, succinate, sulfate, tartrate, thiocyanate, p-toluenesulfonate and undecanoate. Also, the basic nitrogen-containing groups can be quaternized with such agents as alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides, and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides, and others. Water or oil-soluble or dispersible products are thereby obtained. [0124] Examples of acids that may be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, sulfuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, methanesulfonic acid, succinic acid and citric acid. Basic addition salts can be prepared in situ during the final isolation and purification of the compounds of formulae I-VII, or separately by reacting carboxylic acid moieties with a suitable base such as the hydroxide, carbonate or bicarbonate of a pharmaceutically acceptable metal cation or with ammonia, or an organic primary, secondary or tertiary amine. Pharmaceutically acceptable salts include, but are not limited to, cations based on the alkali and alkaline earth metals, such as sodium, lithium, potassium, calcium, magnesium, aluminum salts and the like, as well as ammonium, quaternary ammonium, and amine cations, 64 WO 2006/002236 PCT/US2005/022062 including, but not limited to ammonium, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, ethylamine, and the like. Other representative organic amines useful for the formation of base addition salts include diethylamine, ethylenediamine, ethanolamine, diethanolamine, piperazine and the like. [0125] As used herein, the term "pharmaceutically acceptable ester" refers to esters which hydrolyze in vivo and include those that break down in the human body to leave the parent compound or a salt thereof. Suitable ester groups include, for example, those derived from pharmaceutically acceptable aliphatic carboxylic acids, particularly alkanoic, alkenoic, cycloalkanoic and alkanedioic acids, in which each alkyl or alkenyl moiety advantageously has not more than 6 carbon atoms. Representative examples of particular esters include, but are not limited to, formates, acetates, propionates, butyrates, acrylates and ethylsuccinates. [0126] The term "pharmaceutically acceptable prodrug" as used herein refers to those prodrugs of the compounds of the present invention which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like, commensurate with a reasonable benefit/risk ratio, and effective for their intended use, as well as the zwitterionic forms, where possible, of the compounds of the invention. The term "prodrug" refers to compounds that are rapidly transformed in vivo to yield the parent compound of the above formula, for example by hydrolysis in blood. A discussion is provided in T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol. 14 of the A.C.S. Symposium Series, and in Edward B. Roche, ed., Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987, both of which are incorporated herein by reference. 65 WO 2006/002236 PCT/US2005/022062 [0127] As used herein "anticancer agents" or "agent for the treatment of cancer" refers to agents that include, by way of example only, agents that induce apoptosis; polynucleotides (e.g., ribozymes); polypeptides (e.g., enzymes); drugs; biological mimetics; alkaloids; alkylating agents; antitumor antibiotics; antimetabolites; hormones; platinum compounds; monoclonal antibodies conjugated with anticancer drugs, toxins, and/or radionuclides; biological response modifiers (e.g. interferons and interleukins, etc.); adoptive immunotherapy agents; hematopoietic growth factors; agents that induce tumor cell differentiation (e.g. all-trans-retinoic acid, etc.); gene therapy reagents; antisense therapy reagents and nucleotides; tumor vaccines; inhibitors of angiogenesis, and the like. Numerous other agents are well within the purview of one of skill in the art [0128] It is understood that in all substituted groups defined above, polymers arrived at by defining substituents with further substituents to themselves (e.g., substituted aryl having a substituted aryl group as a substituent which is itself substituted with a substituted aryl group, etc.) are not intended for inclusion herein. In such cases, the maximum number of such substituents is three. That is to say that each of the above definitions is constrained by a limitation that, for example, substituted aryl groups are limited to -substituted aryl-(substituted aryl)-substituted aryl. [0129] Similarly, it is understood that the above definitions are not intended to include impermissible substitution patterns (e.g., methyl substituted with 5 fluoro groups or a hydroxyl group alpha,to ethenylic or acetylenic unsaturation). Such impermissible substitution patterns are well known to the skilled artisan. 66 WO 2006/002236 PCT/US2005/022062 [0130] Compounds of this invention may exhibit stereoisomerism by virtue of the presence of one or more asymmetric or chiral centers in the compounds. The present invention contemplates the various stereoisomers and mixtures thereof. Certain of the compounds of the invention comprise asymmetrically substituted carbon atoms. Such asymmetrically substituted carbon atoms can result in the compounds of the invention comprising mixtures of stereoisomers at a particular asymmetrically substituted carbon atom or a single stereoisomer. As a result, racemic mixtures, mixtures of diastereomers, single enantiomer, as well as single diastereomers of the compounds of the invention are included in the present invention. The terms "S" and "R" configuration, as used herein, are as defined by the IUPAC 1974 "RECOMMENDATIONS FOR SECTION E, FUNDAMENTAL STEREOCHEMISTRY," Pure Appl. Chem. 45:13-30,1976. Desired enantiomers can be obtained by chiral synthesis from commercially available chiral starting materials by methods well known in the art, or may be obtained from mixtures of the enantiomers by separating the desired enantiomer by using known techniques. [0131] Compounds of this invention may also exhibit geometrical isomerism. Geometrical isomers include the cis and trans forms of compounds of the invention having alkenyl or alkenylenyl moieties. The present invention comprises the individual geometrical isomers and stereoisomers and mixtures thereof. B. Compound Preparation [0132] The compounds of this invention can be prepared from readily available starting materials using the following general methods and procedures. Unless otherwise indicated, the starting materials are commercially available and well known in the art. It will be 61 WO 2006/002236 PCT/US2005/022062 appreciated that where typical or preferred process conditions (i.e., reaction temperatures, times, mole ratios of reactants, solvents, pressures) are given, other process conditions can also be used unless otherwise stated. Optimum reaction conditions may vary with the particular reactants or solvent used, but such conditions can be determined by one skilled in the art by routine optimization procedures. [0133] Additionally, as will be apparent to those skilled in the art, conventional protecting groups may be necessary to prevent certain functional groups from undergoing undesired reactions. Suitable protecting groups for various functional groups as well as suitable conditions for protecting and deprotecting particular functional groups are well known in the art. For example, numerous protecting groups are described in T. W. Greene and P. G. M. Wuts, Protecting Groups in Organic Synthesis, Second Edition, Wiley, New York, 1991, and references cited therein. [0134] Furthermore, the compounds of this invention may contain one or more chiral centers. Accordingly, if desired, such compounds can be prepared or isolated as pure stereoisomers, i.e., as individual enantiomers or diastereomers, or as stereoisomer-enriched mixtures. All such stereoisomers (and enriched mixtures) are included within the scope of this invention, unless otherwise indicated. Pure stereoisomers (or enriched mixtures) may be prepared using, for example, optically active starting materials or stereoselective reagents well-known in the art. Alternatively, racemic mixtures of such compounds can be separated using, for example, chiral column chromatography, chiral resolving agents, and the like. [0135] Compounds in the present invention may be better understood by the following synthetic Scheme that illustrate methods for the synthesis of compounds of the 68 WO 2006/002236 PCT/US2005/022062 invention. Unless otherwise indicated, the reagents used in the following examples are commercially available and may be purchased from vendors such as Sigma-Aldrich Company, Inc. (Milwaukee, WI, USA). [0136] Arylimidazole compounds may be synthesized by Scheme 1 below: R1, Ar, A23 and A are as defined herein. -CH2-R4 is R4, where R4 is as defined herein. PG refers to a protecting group, such as BOC. PG' refers to a protecting group, such as phthalimide. X refers to a halide, such as bromo. 69 WO 2006/002236 PCT/US2005/022062 [0137] Specifically, in Scheme 1, an appropriately protected (PG) amino acid 1000, is dissolved in a suitable amount of an inert solvent, such as methanol or ethanol. It should be noted amino acid 1000 is typically commercially available as are a,a-disubstituted amino acids (PG-NH-C(R1)(R2)-COOH). To that is added about a stoichiometric amount of a monovalent cation, such as cesium carbonate (CS2CO3), to form the carboxylate salt (not shown). Upon substantial completion of the reaction, typically about 15 minutes to about 2 hours, excess solvent is removed under reduced pressure. The remaining salt is then re-dissolved in a suitable solvent, such as DMF, and then treated with 1 to 4 equivalents of the appropriate a-halo ketone 1001, for example 2-bromoacetophenone and then stirred at room temperature until the reaction is substantially complete. [0138] The resulting P-ketoester 1002 can be recovered and optionally purified by conventional methods, such as precipitation, filtration, evaporation, crystallization and the like. Alternatively, ?-ketoester 1002 can be used directly in the next step without purification or isolation. [0139] Next, to a stirred solution of ?-ketoester 1002 in a suitable inert solvent, such as toluene, xylenes, and the like is added an excess of ammonium acetate, typically from about 2 to about 20 equivalents and preferably about 5 equivalents. In one embodiment, a Dean-Stark trap is added and the resulting mixture is heated at elevated temperatures of from about 120 to about 160°C until the reaction is complete. Once complete, the mixture is allowed to cool to room temperature. The resulting arylimidazole 1003 is then recovered and optionally purified by conventional methods such as precipitation, filtration, evaporation, crystallization, 70 WO 2006/002236 PCT/US2005/022062 chromatography and the like. Alternatively, arylimidazole 1003 may be used in the,next step without purification and/or isolation. [0140] The arylimidazole 1003 is then reacted with an appropriate aryl or heteroaryl-substituted alkyl halide, such as benzyl bromide. Typically, this can be accomplished by stirring the arylimidazole 1003 with an excess of potassium carbonate and DMF and then adding at least an equimolar amount of the aryl or heteroaryl-substituted alkyl halide. [0141] Compounds of the invention when R5 is L-A1 and L is -S(O)q-, may be synthesized using a suitable sulfonyl chloride. Descriptions of various suflonyl chlorides may be found, for example, in U.S. Patent 6,489,300, which is hereby incorporated by reference. [0142] The protecting group, PG is then removed by conventional techniques to provide amine 1004, which is then optionally purified by conventional means such as precipitation, filtration, evaporation, crystallization, chromatography and the like. Alternatively, amine 1004 can be.used directly in the next step without purification and/or isolation. [0143] Amine 1004 is reacted under conventional reductive amination conditions with aldehyde 1005 to provide for substituted amine 1006 which is then recovered and optionally purified by conventional methods such as precipitation, filtration, evaporation, crystallization, chromatography and the like. Alternatively, substituted amine 1006 can be used directly in the next step without purification and/or isolation. [0144] Substituted amine 1006 is then reacted under conventional amidation conditions with acyl chloride 1007. Any protecting groups, such as PG', remaining on the resulting amide product, 1008, can be removed by conventional methods and the product can be 71 WO 2006/002236 PCT/US2005/022062 recovered and purified by conventional methods such as precipitation, filtration, evaporation, crystallization, chromatography and the like. [0145] It will be well within the skill of the art to further modify the above preparation to synthesize other compounds of this invention. C. Pharmaceutical Formulations [0146] When employed as Pharmaceuticals, the compounds of the subject invention are usually administered in the form of pharmaceutical compositions. These compositions can be administered by a variety of routes including oral, parenteral, transdermal, topical, rectal, and intranasal. These compounds are effective, for example, as both injectable and oral compositions. Such compositions are prepared in a manner well known in the pharmaceutical art and comprise at least one active compound. [0147] This invention also includes pharmaceutical compositions which contain, as the active ingredient, one or more of the compounds of the subject invention above associated with pharmaceutically acceptable carriers. In making the compositions of this invention, the active ingredient is usually mixed with an excipient, diluted by an excipient or enclosed within such a carrier which can be in the form of a capsule, sachet, paper or other container. The excipient employed is typically an excipient suitable for administration to human subjects or other mammals. When the excipient serves as a diluent, it can be a solid, semi-solid, or liquid material, which acts as a vehicle, carrier or medium for the active ingredient. Thus, the compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments 72 WO 2006/002236 PC17US2005/022062 containing, for example,* up to 10% by weight of the active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and sterile packaged powders. [0148] In preparing a formulation, it may be necessary to null the active compound to provide the appropriate particle size prior to combining with the other ingredients. If the active compound is substantially insoluble, it ordinarily is milled to a particle size of less than 200 mesh. If the active compound is substantially water soluble, the particle size is normally adjusted by milling to provide a substantially uniform distribution in the formulation, e.g., about 40 mesh. [0149] Some examples of suitable excipients include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, sterile water, syrup, and methyl cellulose. The formulations can additionally include: lubricating agents such as talc, magnesium stearate, and mineral oil; wetting agents; emulsifying and suspending agents; preserving agents such as methyl- and propylhydroxy-benzoates; sweetening agents; and flavoring agents. The compositions of the invention can be formulated so as to provide quick, sustained or delayed release of the active ingredient after administration to the patient by employing procedures known in the art. [0150] The quantity of active component, that is the compound according to the subject invention, in the pharmaceutical composition and unit dosage form thereof may be varied or adjusted widely depending upon the particular application, the potency of the particular compound and the desired concentration. 73 WO 2006/002236 PCT/US2005/022062 [0151] The compositions are preferably formulated in a unit dosage form, each dosage containing from about 1 to about 500 mg, usually about 5 to about 100 mg,.occasionally about 10 to about 30 mg, of the active ingredient. The term "unit dosage forms" refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical excipient. Preferably, the compound of the subject invention above is employed at no more than about 20 weight percent of the pharmaceutical composition, more preferably no more than about 15 weight percent, with the balance being pharmaceutically inert carrier(s). [0152] The active compound is effective over a wide dosage range and is generally administered in a pharmaceutically or therapeutically effective amount. It will be understood, however, that the amount of the compound actually administered will be determined by a physician, in the light of the relevant circumstances, including the condition to be treated, the severity of the condition being treated, the chosen route of administration, the actual compound administered, the age, weight, and response of the individual patient, the severity of the patient's symptoms, and the like. [0153] In therapeutic use for treating, or combating, cancer in mammals, the compounds or pharmaceutical compositions thereof will be administered by any appropriate route, such as orally, topically, transdermally, and/or parenterally at a dosage to obtain and maintain a concentration, that is, an amount, or blood-level of active component in the mammal undergoing treatment that will be therapeutically effective. Generally, such therapeutically 74 WO 2006/002236 PCT/US2005/022062 effective amount of dosage of active component (i.e., an effective dosage) will be in the range of about 0.1 to about 100, more preferably about 1.0 to about 50 mg/kg of body weight/day. [0154] For preparing solid compositions such as tablets, the principal active ingredient is mixed with a pharmaceutical excipient to form a solid prefbrmulation composition containing a homogeneous mixture of a compound of the present invention. When referring to these preformulation compositions as homogeneous, it is meant that the active ingredient is dispersed evenly throughout the composition so that the composition may be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules. This solid preformulation is then subdivided into unit dosage forms of the type described above containing from, for example, 0.1 to about 500 mg of the active ingredient of the present invention. [0155] The tablets or pills of the present invention may be coated or otherwise compounded to provide a dosage form affording the advantage of prolonged action. For example, the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former. The two components can be separated by an enteric layer which serves to resist disintegration in the stomach and permit the inner component to pass intact into the duodenum or to be delayed in release. A variety of materials can be used for such enteric layers or coatings, such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shellac, cetyl alcohol, and cellulose acetate. [0156] The liquid forms in which the novel compositions of the present invention may be incorporated for administration orally or by injection include aqueous solutions, suitably flavored syrups, aqueous or oil suspensions, and flavored emulsions with 75 WO 2006/002236 PCT/US2005/022062 edible oils such as corn oil, cottonseed oil, sesame oil, coconut oil, or peanut oil, as well as elixirs and similar pharmaceutical vehicles. [0157] Compositions for inhalation or insufflation include solutions and suspensions in pharmaceutically acceptable, aqueous or organic solvents, or mixtures thereof, and powders. The liquid or solid compositions may contain suitable pharmaceutically acceptable excipients as described supra. Preferably the compositions are administered by the oral or nasal respiratory route for local or systemic effect. Compositions in preferably pharmaceutically acceptable solvents may be nebulized by use of inert gases. Nebulized solutions may be inhaled directly from the nebulizing device or the nebulizing device may be attached to a face mask tent, or intermittent positive pressure breathing machine. Solution, suspension, or powder compositions may be administered, preferably orally or nasally, from devices which deliver the formulation in an appropriate manner. [0158] The following formulation examples illustrate representative pharmaceutical compositions of the present invention. Formulation Example 1 [0159] Hard gelatin capsules containing the following ingredients are prepared: Quantity Ingredient (mg/capsule)Active Ingredient 30.0 Starch 305.0 Magnesium stearate 5.0 [0160] The above ingredients are mixed and filled into hard gelatin capsules in 340 mg quantities. 16 WO 2006/002236 PCT/US2005/022062 Formulation Example 2 [0161] A tablet formula is prepared using the ingredients below: Quantity Ingredient (mg/tablet) Active Ingredient 25.0 Cellulose, microcrystalline 200.0 Colloidal silicon dioxide 10.0 Stearic acid 5.0 [0162] The components are blended and compressed to form tablets, each weighing 240 mg. Formulation Example 3 [0163] A dry powder inhaler formulation is prepared containing the following components: Ingredient Weight %Active Ingredient 5 Lactose 95 [0164] The active ingredient is mixed with the lactose and the mixture is added to a dry powder inhaling appliance. 77 WO 2006/002236 PCT/US2005/022062 Formulation Example 4 [0165] Tablets, each containing 30 mg of active ingredient, are prepared as follows Quantity Ingredient (mg/tablet)Active Ingredient 30.0 mg Starch 45.0 mg Microcrystalline cellulose 35.0 mg . Polyvinylpyrrolidone 4.0 mg (as 10% solution in sterile water) Sodium carboxymethyl starch 4.5 mg Magnesium stearate 0.5 mg Talc l.0mg Total 120 mg [0166] The active ingredient, starch and cellulose are passed through a No. 20 mesh U.S. sieve and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders, which are then passed through a 16 mesh U.S. sieve. The granules so produced are dried at 50°C to 60°C and passed through a 16 mesh U.S. sieve. The sodium carboxymethyl starch, magnesium stearate, and talc, previously passed through a No. 30 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 120 mg. Formulation Example 5 [0167] Capsules, each containing 40 mg of medicament are made as follows: Quantity Ingredient (mg/capsule)Active Ingredient 40.0 mg Starch 109.0 mg Magnesium stearate 1.0 mg Total 150.0 mg 78 WO 2006/002236 PCT/US2005/022062 [0168] The active ingredient, starch, and magnesium stearate are blended, passed through a No. 20 mesh U.S. sieve, and filled into hard gelatin capsules in 150 mg quantities. Formulation Example 6 [0169] Suppositories, each containing 25 mg of active ingredient are made as follows: Ingredient AmountActive Ingredient 25 mg Saturated fatty acid glycerides to 2,000 mg [0170] The active ingredient is passed through a No. 60 mesh U.S. sieve and suspended in the saturated fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a suppository mold of nominal 2.0 g capacity and allowed to cool. Formulation Example 7 [0171] Suspensions, each containing 50 mg of medicament per 5.0 ml dose are made as follows: Ingredient AmountActive Ingredient 50.0 mg Xanthan gum 4.0 mg Sodium carboxymethyl cellulose (11%) Microcrystalline cellulose (89%) 50.0 mg Sucrose 1.75 g Sodium benzoate 10.0 mg Flavor and Color q.v. Purified water to 5.0 ml [0172] The active ingredient, sucrose and xanthan gum are blended, passed through a No. 10 mesh U.S. sieve, and then mixed with a previously made solution of the 79 WO 2006/002236 PCT/US2005/022062 microcrystalline cellulose and sodium carboxymethyl cellulose in water. The sodium benzoate, flavor, and color are diluted with some of the water and added with stirring. Sufficient water is then added to produce the required volume. Formulation Example 8 Quantity Ingredient (mg/capsule). Active Ingredient 15.0 mg Starch 407.0 mg Magnesium stearate - 3.0 mg Total 425.0 mg [0173] The active ingredient, starch, and magnesium stearate are blended, passed through a No. 20 mesh U.S. sieve, and filled into hard gelatin capsules in 425.0 mg quantities. Formulation Example 9 [0174] A subcutaneous formulation may be prepared as follows: Ingredient QuantityActive Ingredient 5.0 mg Corn Oil 1.0 ml Formulation Example 10 [0175] A topical formulation may be prepared as follows: Ingredient Quantity Active Ingredient 1 -10 g Emulsifying Wax 30 g Liquid Paraffin 20 g White Soft Paraffin to 100 g 80 WO 2006/002236 PCT/US2005/022062 [0176] The white soft paraffin is heated until molten. The liquid paraffin and emulsifying wax are incorporated and stirred until dissolved. The active ingredient is added and stirring is continued until dispersed. The mixture is then cooled until solid. Formulation Example 11 [0177] An intravenous formulation may be prepared as follows: Ingredient QuantityActive Ingredient 250 mg Isotonic saline 1000 ml [0178] Another preferred formulation employed in the methods of the present invention employs transdermal delivery devices ("patches"). Such transdermal patches may be used to provide continuous or discontinuous infusion of the compounds of the present invention in controlled amounts. The construction and use of transdermal patches for the delivery of pharmaceutical agents is well known in the art. See, e.g., U.S. Patent 5,023,252, issued June 11, 1991, herein incorporated by reference. Such patches may be constructed for continuous, pulsatile, or on demand delivery of pharmaceutical agents. [0179] Frequently, it will be desirable or necessary to introduce the pharmaceutical composition to the brain, either directly or indirectly. Direct techniques usually involve placement of a drug delivery catheter into the host's ventricular system to bypass the blood-brain barrier. One such implantable delivery system used for the transport of biological factors to specific anatomical regions of the body is described in U.S. Patent 5,011,472 which is herein incorporated by reference. [01S0] Indirect techniques, which are generally preferred, usually involve formulating the compositions to provide for drug latentiation by the conversion of hydrophilic 81 WO 2006/002236 PCT/US2005/022062 drugs into lipid-soluble drugs. Latentiation is generally achieved through blocking of the hydroxy, carbonyl, sulfate, and primary amine groups present on the drug to render the drug more lipid soluble and amenable to transportation across the blood-brain barrier. Alternatively, the delivery of hydropbilic drugs may be enhanced by intra-arterial infusion of hypertonic solutions which can transiently open the blood-brain barrier. [0181] Other suitable formulations for use in the present invention can be found in Remington's Pharmaceutical Sciences, Mack Publishing Company, Philadelphia, PA, 17th ed. (1985). D. Dosage and Administration [0182] As noted above, the compounds described herein are suitable for use in a variety of drug delivery systems described above. Additionally, in order to enhance the in vivo serum half-life of the administered compound, the compounds may be encapsulated, introduced into the lumen of liposomes, prepared as a colloid, or other conventional techniques may be employed which provide an extended serum half-life of the compounds. A variety of methods are available for preparing liposomes, as described in, e.g., Szoka, et al., U.S. Patent Nos. 4,235,871,4,501,728 and 4,837,028 each of which is incorporated herein by reference, [0183] Compounds of the instant invention are useful for inhibiting or treating a disorder mediated, at least in part, by the activity of KSP. In one aspect, the disorder that is mediated, at least in part by KSP, is a cellular proliferative disorder. The term "cellular proliferative disorder" or "cell proliferative disorder" refers to diseases including, for example, cancer, tumor, hyperplasia, restenosis, cardiac hypertrophy, immune disorder and inflammation. The present invention provides methods of treating a human or mammalian subject in need of 82 WO 2006/002236 PCT/US2005/022062 such treatment, comprising administering to the subject a therapeutically effective amount of a compound of formulae I-VII, either alone or in combination with other anticancer agents. [0184] The compounds of the invention are useful in vitro or in vivo in inhibiting the growth of cancer cells. The term "cancer" refers to cancer diseases including, for example, lung and bronchus; prostate; breast; pancreas; colon and rectum; thyroid; stomach; liver and intrahepatic bile duct; kidney and renal pelvis; urinary bladder; uterine corpus; uterine cervix; ovary; multiple myeloma; esophagus; acute myelogenous leukemia; chronic myelognous leukemia; lymphocytic leukemia; myeloid leukemia; brain; oral cavity and pharynx; larynx; small intestine; non-hodgkin lymphoma; melanoma; and villous colon adenoma. [0185] Cancer also includes tumors or neoplasms selected from the group consisting of carcinomas, adenocarcinomas, sarcomas, and hematological malignancies. [0186] Additionally, the type of cancer can be selected from the group consisting of growth of solid tumors/malignancies, myxoid and round cell carcinoma, locally advanced tumors, human soft tissue carcinoma, cancer metastases, squamous cell carcinoma, esophageal squamous cell carcinoma, oral carcinoma, cutaneous T cell lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, cancer of the adrenal cortex, ACTH-producing tumors, nonsmall cell cancers, breast cancer, gastrointestinal cancers, urological cancers, malignancies of the female genital tract, malignancies of the male genital tract, kidney cancer, brain cancer, bone cancers, skin cancers, thyroid cancer, retinoblastoma, neuroblastoma, peritoneal effusion, malignant pleural effusion, mesothelioma, Wilms's tumors, gall bladder cancer, trophoblastic neoplasms, hemangiopericytoma, and Kaposi's sarcoma. 83 WO 2006/002236 PCT/US2005/022062 [0187] A compound or composition of this invention may be administered to the mammal by a suitable route, such as orally, intravenously, parenterally, transdermally, topically, rectally, or intranasally. [01S8] Mammals include, for example, humans and other primates, pet or companion animals, such as dogs and cats, laboratory animals, such as rats, mice and rabbits, and farm animals, such as horses, pigs, sheep, and cattle. [0189] Tumors or neoplasms include growths of tissue cells in which the multiplication of the cells is uncontrolled and progressive. Some such growths are benign, but others are termed "malignant" and can lead to death of the organism. Malignant neoplasms or "cancers" are distinguished from benign growths in that, in addition to exhibiting aggressive cellular proliferation, they can invade surrounding tissues and metastasize. Moreover, malignant neoplasms are characterized in that they show a greater loss of differentiation (greater "dedifferentiation") and organization relative to one another and to surrounding tissues. This property is called "anaplasia." [0190] Compounds having the desired biological activity may be modified as necessary to provide desired properties such as improved pharmacological properties {e.g., in vivo stability, bio-availability), or the ability to be detected in diagnostic applications. Stability can be assayed in a variety of ways such as by measuring the half-life of the compounds during incubation with peptidases or human plasma or serum. [0191] For diagnostic purposes, a wide variety of labels may be linked to the, compounds, which may provide, directly or indirectly, a detectable signal. Thus, the compounds and/or compositions of the subject invention may be modified in a variety of ways for a variety 84 WO 2006/002236 PCT/US2005/022062 of end purposes while still retaining biological activity. In addition, various reactive sites may be introduced for linking to particles, solid substrates, macromolecules, and the like. [0192] Labeled compounds can be used in a variety of in vivo or in vitro applications. A wide variety of labels may be employed, such as radionuclides (e.g., gamma-emitting radioisotopes such as technetium-99 or indium-111), fluorescers (e.g., fluorescein), enzymes, enzyme substrates, enzyme cofactors, enzyme inhibitors, chemiluminescent compounds, bioluminescent compounds, and the like. Those of ordinary skill in the art will know of other suitable labels for binding to the complexes, or will be able to ascertain such using routine experimentation. The binding of these labels is achieved using standard techniques common to those of ordinary skill in the art. [0193J Pharmaceutical compositions of the invention are suitable for use in a variety of drug delivery systems. Suitable formulations for use in the present invention are found in Remington's Pharmaceutical Sciences, Mace Publishing Company, Philadelphia, Pa., 17th ed. (1985). [0194] The amount administered to the patient will vary depending upon what is being administered, the purpose of the administration, such as prophylaxis or therapy, the state of the patient, the manner of administration, and the like. In therapeutic applications, compositions are administered to a patient already suffering from a disease in an amount sufficient to cure or at least partially arrest the progression or symptoms of the disease and its complications. An amount adequate to accomplish this is defined as "therapeutically effective dose." Amounts effective for this use will depend on the disease condition being treated as well as by the 85 WO 2006/002236 PCT/US2005/022062 judgment of the attending clinician depending upon factors such as the severity of the disease, disorder or condition, the age, weight and general condition of the patient, and the like. [0195] The compounds administered to a patient are typically in the form of pharmaceutical compositions described above. These compositions may be sterilized by conventional sterilization techniques, or may be sterile filtered. The resulting aqueous solutions may be packaged for use as is, or lyophilized, the lyophilized preparation being combined with a sterile aqueous carrier prior to administration. The pH of the compound preparations typically will be between about 3 and 11, more preferably from about 5 to 9 and most preferably from about 7 to 8. It will be understood that use of certain of the foregoing excipients, carriers, or stabilizers will result in the formation of pharmaceutical salts. [0196] The therapeutic dosage of the compounds and/or compositions of the present invention will vary according to, for example, the particular use for which the treatment is made, the manner of administration of the compound, the health and condition of the patient, and the judgment of the prescribing physician. For example, for oral administration, the dose will typically be in the range of about 5 (ig to about 50 mg per kilogram body weight per day, preferably about 1 mg to about 10 mg per kilogram body weight per day. In the alternative, for intravenous administration, the dose will typically be in the range of about 5 ug to about 50 mg per kilogram body weight, preferably about 500 ug to about 5000 ug per kilogram body weight. Alternative routes of administration contemplated include, but are not limited to, intranasal, transdermal, inhaled, subcutaneous and intramuscular. Effective doses can be extrapolated from dose-response curves derived from in vitro or animal model test systems. 86 WO 2006/002236 PCT/US2005/022062 [0197] In general, the compounds and/or compositions of the subject invention will be administered in a therapeutically effective amount by any of the accepted modes of administration for agents that serve similar utilities. Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Compounds that exhibit large therapeutic indices are preferred. [0198] The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED50 with little or no . toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound and/or composition used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range which includes the IC50 (the concentration of the test compound which achieves a half-maximal inhibition of activity) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography. [0199] The following synthetic and biological examples are offered to illustrate this invention and are not to be construed in any way as limiting the scope of this invention. 87 WO 2006/002236 PCT/US2005/022062 EXAMPLES [0200] Referring to the examples that follow, compounds of the present invention were synthesized using the methods described herein, or other methods, which are well known in the art. [0201] The compounds and/or intermediates were characterized by high performance liquid chromatography (HPLC) using a Waters Millenium chromatography system with a 2690 Separation Module (Milford, MA). The analytical columns were Alltima C-18 reversed phase, 4.6 x 250 mm from Alltech (Deerfield, IL). A gradient elution was used, typically starting with 5% acetonitrile/95% water and progressing to 100% acetonitrile over a period of 40 minutes. All solvents contained 0.1% trifluoroacetic acid (TFA). Compounds were detected by ultraviolet light (UV) absorption at either 220 or 254 nm. HPLC solvents were from Burdick and Jackson (Muskegan, MI), or Fisher Scientific (Pittsburgh, PA). In some instances, purity was assessed by thin layer chromatography (TLC) using glass or plastic backed silica gel plates, such as, for example, Baker-Flex Silica Gel 1B2-F flexible sheets. TLC results were readily detected visually under ultraviolet light, or by employing well known iodine vapor and other various staining techniques. [0202] Mass spectrometric analysis was performed on one of two LCMS instruments: a Waters System (Alliance HT HPLC and a Micromass ZQ mass spectrometer; Column: Eclipse XDB-C18,2.1 x 50 mm; solvent system: 5-95% (or 35-95%, or 65-95% or 95-95%) acetonitrile in water with 0.05% TFA; flow rate 0.8 ml/min; molecular weight range 500-1500; cone Voltage 20 V; column temperature 40°C) or a Hewlett Packard System (Series 1100 HPLC; Column: Eclipse XDB-C18,2.1 x 50 mm; solvent system: 1-95% acetonitrile in 88 WO 2006/002236 PCT/US2005/022062 water with 0.05% TFA; flow rate 0.4 ml/min; molecular weight range 150-850; cone Voltage 50 V; column temperature 30°C). All masses were reported as those of the protonated parent ions. [0203] GCMS analysis is performed on a Hewlett Packard instrument (HP6890 Series gas chromatograph with a Mass Selective Detector 5973; injector volume: 1 ml; initial column temperature: 50°C; final column temperature: 250°C; ramp time: 20 minutes; gas flow rate: 1 ml/min; column: 5% phenyl methyl siloxane, Model No. HP 190915-443, dimensions: 30.0 m x 25 m x 0.25 m). [0204] Nuclear magnetic resonance (NMR) analysis was performed on some of the compounds with a Varian 300 MHz NMR (Palo Alto, CA). The spectral reference was either TMS or the known chemical shift of the solvent. Some compound samples were run at elevated temperatures (e.g., 75°C) to promote increased sample solubility. [0205] The purity of some of the invention compounds is assessed by elemental analysis (Desert Analytics, Tucson, AZ). [0206] Melting points are determined on a Laboratory Devices Mel-Temp apparatus (Holliston, MA). [0207] Preparative separations were carried out using a Flash 40 chromatography system and KP-Sil, 60A (Biotage, Charlottesville, VA), or by flash column chromatography using silica gel (230-400 mesh) packing material, or by HPLC using a C-18 reversed phase column. Typical solvents employed for the Flash 40 Biotage system and flash column chromatography were dichloromethane, methanol, ethyl acetate, hexane, acetone, aqueous hydroxyamine and triethyl amine. Typical solvents employed for the reverse phase HPLC were varying concentrations of acetonitrile and water with 0.1% trifiuoroacetic acid. 89 WO 2006/002236 PCT/US2005/022062 [0208] Unless otherwise stated all temperatures are in degrees Celsius. Also, in these examples and elsewhere, abbreviations have the following meanings: µg = nucrograms µ1 = microliter µM = Micromolar AcOH = acetic acid aq = Aqueous ATP = adenosine 5'-triphosphate Boc = t-butoxycarbonyl BSA = bovine serum albumin cbz = Benzyloxycarbonyl DCM = Dichloromethane DIAD = diisopropyl azodicarboxylate DIBAL = diisobutylaluminum hydride DIPEA = Diisopropylethylamine DMAP = Dimethylaminopyridine DMF = dimethyl formamide DMSO = Dimethylsulfoxide DTT = Dithiothreitol EDC = ethylene dichloride eq. = Equivalents ES/MS = electrospray mass spectroscopy Et = Ethyl Et2O = diethyl ether Et3N = triethyl amine EtOAc = ethyl acetate EtOH = Ethanol g = Gram GCMS = gas chromatography mass spectroscopy h = Hour HOAT = 1 -Hydroxy-7-azabenzotriazole' HPLC = high performance liquid chromatography kg = Kilogram L = Liter LCMS = liquid chromatography mass Spectroscopy LiHMDS = lithium hexamethyldisilazide M = Molar m = Meter m/z = mass/charge ratio MeOH = Methanol 90 WO 2006/002236 PCT/US2005/022062 mg = milligram min = minute ml = milliliter mM = millimolar mm = millimeter mM = millimolar mmol = millimole mol = mole N = normal nm = nanometer NMR = nuclear magnetic resonance PTFE = Teflon tetrafluoroethylene PyBOP = Benzotriazole-1-yl-oxy- trispyrrblidinophosphonium hexafluorophqsphate room temperature or r.t = room temperature sat = saturated TEA = triethylamine TFA = trifluoroacetic acid THF = tetrahydrofuran TMS = tetramethylsilane TMSC1 = trimethylsilyl chloride 9 Example 1 Preparation of Compounds of the Invention of the Following Formula: WO 2006/002236 PCT/US2005/022062 where R1 is as defined herein [0209] A stirred solution of the appropriate N-Boc-acid 1-1 (4.0 mmol) in EtOH (10 ml) was treated with CS2CO3 (2.0 mmol). After 45 min, the EtOH was removed by evaporation under reduced pressure. The residual cesium salt was re-dissolved in DMF (15 ml) and the treated with the appropriate a-halo-ketone 1-2, e.g., 2-bromoacetophenone (4.0 mmol) and stirred at room temperature until the reaction was complete. The reaction mixture was then partitioned between EtOAc and H2O, and the organics separated, then washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the keto-ester 1-3 which was pure enough to use directly in the next step. [0210] To a stirred solution of keto-ester 1-3 (4.0 mmol) in xylenes (40 ml) was added ammonium acetate (20 mmol). A Dean-Stark trap was added and the reaction heated to 140°C. Once the reaction was complete, the mixture was allowed to cool to room temperature, 92 WO 2006/002236 PCT/US2005/022062 then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole 1-4 which was pure enough to use directly in the next step. [0211] To a stirred solution/ suspension of imidazole 1-4 (4.0 mmol) and K2CO3 (8.0 mmol) in DMF (10 ml) was added the benzylating agent, e.g., benzyl bromide (4.40 mmol). Once the reaction was complete, the mixture was partitioned between EtOAc and H2O. The organic layer was separated and washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude benzylated phenyl imidazole 1-6. The crude reaction material was then crystallized (EtOAc, hexanes) to give pure product. The regiochemical outcome was verified by 1H NMR. 93 WO 2006/002236 PCT/US2005/022062 [0212] Boc-protected amine 1-6 (1.0 mmol) was treated with 10% TFA in CH2Cl2 (5 ml). Once reaction was complete, the reaction was concentrated in vacuo and then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole free amine 1-7 which was pure enough to use directly in the next step. [0213] To a stirred solution of amine 1-7 (1.0 mmol) and appropriate aldehyde 1-8, e.g., 2-(3-oxopropyl)benzo[c]azoline-l,3-dione (1.0 mmol) in CH2Cl2 (7 ml) was added AcOH (1.0 mmol). The mixture was allowed to stir for 5 min before the addition of sodium tris-acetoxyborohydride (1.10 mmol). Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between EtOAc and 2 M aq. Na2CO3. The organics were separated, then washed with 2 M aq. Na2CO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 1-9 which was either purified by reverse phase prep. HPLC, or more usually was pure enough to use directly in the next step. 94 WO 2006/002236 PCT/US2005/022062 [0214] To a stirred solution of amine 1-9 (1.0 mmol) in CH2Cl2 (6 ml) was added Et3N (2.0 mmol) followed by the appropriate acid chloride 1-10, e.g., benzoyl chloride (1.0 mmol). Once the reaction was complete, the mixture was partitioned between CH2Cl2 and sat. aq. NaHCO3. The organics were separated and washed with H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 1-11. [0215] To a non-stirred solution of phthalimido compound 1-12 (0.3 mmol) in EtOH (1.5 ml) was added anhydrous hydrazine (1.5 mmol). Once the reaction was complete, the reaction was filtered, and the filtrate evaporated under reduced pressure to give the title compound which was purified by reverse phase prep. HPLC to give the pure product 1-13. 95 WO 2006/002236 PCT/US2005/022062 Example 2 Preparation of N-[(2S)-3-ammo-2-hydroxypropyI]-N-{(lR)-l-(l-benzyl-4-phenyHH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide (Compound 175) [0216] A stirred solution of the appropriate N-Boc-acid (4.0 mmol), compound 2-1, tert-butyl glycine, in EtOH (10 ml) was treated with Cs2CO3 (2.0 mmol). After 45 min, the EtOH was removed by evaporation under reduced pressure. The residual cesium salt was re-dissolved in DMF (15 ml) and the treated with the appropriate tx-halo-ketone, eg, 2-bromoacetophenone (4.0 mmol) and stirred at r.t. until the reaction was complete. The reaction mixture was then partitioned between EtOAc and H2O, and the organics separated, then washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the keto-ester 2-2 which was pure enough to use directly in the next step. [0217] To a stirred solution of keto-ester 2-2 (4.0 mmol) in xylenes (40 ml) was added ammonium acetate (20 mmol). A Dean-Stark trap was added and the reaction heated to 96 WO 2006/002236 PCT/US2005/022062 140°C. Once the reaction was complete, the mixture was allowed to cool to r.t, then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole 2-3 which was pure enough to use directly in the next step. [0218] To a stirred solution/ suspension of imidazole 2-3 (4.0 mmol) and K2CO3 (8.0 mmol) in DMF (10 ml) was added the benzylating agent, eg, benzyl bromide (4.40 mmol). Once the reaction was complete, the mixture was partitioned between EtOAc and H2O. The organic layer was separated and washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude benzylated phenyl imidazole. The crude reaction material was then crystallized (EtOAc, hexanes) to give pure product 2-4. 97 WO 2006/002236 PCT/US2005/022062 [0219] Boc-protected amine 2-4 (1.0 mraol) was treated with 10% TFA in CH2Cl2 (5 ml). Once reaction was complete, the reaction was concentrated in vacuo and then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole free amine 2-5 which was pure enough to use directly in the next step. [0220] To a stirred solution of Cbz protected amino alcohol 2-6 (12.25 mmpl) in acetone (50 ml) was added dimethoxypropane (24.5 mmol) followed by BF3 etherate (20 uL, catalytic amount). After 16 h, fiirther dimethoxypropane (80.6 mmol) was added and stirring continued for a further 16 h. The mixture was then concentrated under reduced pressure, then partitioned between EtOAc and sat. aqueous NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude compound. Purification by silica gel chromatography afforded the ester product 2-7. 98 WO 2006/002236 PCT/US2005/022062 [0221] To a cooled (-78°C), stirred solution of ester 2-7 (5.11 mmol) in toluene (25 ml) was added DIBAL-H (6.64 mmol) dropwise. After 3h, the reaction was quenched by cautious addition of sat. aqueous NH4CI (40 ml). The mixture was diluted with EtOAc, the organic phase was separated, the aqueous extracted with EtOAc (x2). The organics were combined, then washed with 10% Rochelle's Salt (x3), H2O (xl), brine (x3) then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude aldehyde 2-8 which was used directly in the reductive amination. [0222] To a stirred solution of (R)-amine 2-5 from step D (1.15 mmol) and aldehyde 2-8, (1.0 mmol) in CH2C12 (10 ml) was added AcOH (1.15 mmol) followed by the 99 WO 2006/002236 PCT/US2005/022062 addition of sodium tris-acetoxyborohydride (1.28 mmol). Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between EtOAc and 1M NaOH. The organics were separated, then washed with 1M NaOH (x2), H2O (xl), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give crude product 2-9 which was used directly in the next step. [0223] To a stirred solution of amine 2-9 (0.25 mmol) in CH2C12 (2 ml) was added DIPEA (0.5 mmol) followed by the appropriate acid chloride, e.g., benzoyl chloride (0.27 mmol). Once the reaction was complete, the mixture was partitioned between CH2Cl2 and sat. aq. NaHCO3. The organics were separated and washed with H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 2-10 which was used directly in the next step. 100 WO 2006/002236 PCT/US2005/022062 [0224] A solution of Cbz-protected amine 2-10 from step H (0.25 mmol) in MeOH was hydrogenated in the presence of a catalytic amount of 10% Pd/C under an atmosphere of hydrogen. After 2 h, the solution was filtered (Celite) then concentrated under reduced pressure. The residue was treated with 10% TFA/CH2Cl2 (5 ml). Once reaction was complete, the reaction was evaporated under reduced pressure to give the title compound which was purified by reverse phase prep. HPLC to give the pure Compound 175 in Table 2. Example 3 [0225] A mixture of N-Boc-3-formyl pyrrolidine (50 mmol), TMSC1 (125 mmol) and Et3N (250 mmol) in DMF (60 ml) were heated for 6 h. The mixture was then diluted 101 WO 2006/002236 PCT/US2005/022062 with hexanes and filtered (Celite). The filtrate was then evaporated under reduced pressure to give the TMS enol ethers 3-1 as a mixture of E and Z isomers that were used directly in the next step. [0226] To a solution of TMS enol ether 3-1 (3.7 mmol) in acetone (8 ml) was added a solution of N-methyl morpholine N-oxide (5.5 mmol) in H2O (1.2 ml). To this rapidly stirred solution was added OSO40.074 mmol). After 3 h, the mixture was evaporated to dryness under reduced pressre azeotroping with benzene (3x5 ml) to give the crude hydroxy aldehyde. Purification by silica gel chromatography afforded pure hydroxy aldehyde 3-2. 102 WO 2006/002236 PCT/US2005/022062 [0227] To a stirred solution of (R)-amine 3-3 (0.282 mmol) and aldehyde 3-2, (0.3 mmol) in CH2C12 (3 ml) was added AcOH (0.31 mmol) followed by the addition of sodium tris-acetoxyborohydride (0.31 mmol). Compound 3-3 was synthesized in a manner similar to Example 1, utilizing the appropriately fluoro-substituted starting materials. After 18h, further sodium tris-acetoxyborohydride (0.157 mmol) was added. Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between EtOAc and 1M NaOH. The organics were separated, then washed with 1M NaOH (x2), H2O (xl), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give crude product. Purification by silica gel chromatography affored a single diastereomer 3-4, though it was unknown whether it was the R,R or R,S diastereomer. [0228] To a stirred solution of amino alcohol 3-4 (0.115 mmol) in CH2C12 (1.0 ml) was added DIPEA (0.575 mmol) followed by chloroacetyl chloride (0.127 mmol). After lh, further chloroacetyl chloride (0.075 mmol) followed by DIPEA (0.287 mmol). Once the reaction was complete, the mixture was evaporated under reduced pressure to give the spiro compound 3-5 which was used directly in the next step. 103 WO 2006/002236 PCT/US2005/022062 [0229] Boc-protected amine 3-5 (0.115 mmol) was treated with 10% TFA/ CH2Cl2 (3 ml). Once reaction was complete, the reaction was evaporated under reduced pressure to give the title compound which was purified by reverse phase prep. HPLC to give the pure compound 404 in Table 3. 104 WO 2006/002236 PCT/US2005/022062 [0230] To a solution of TMS enol ether 3-1 from Step A of Example 3 (42 mmol) in CH3CN (400 ml) was added SelectFluor® (available from Air Products and Chemicals, Inc.) (43.2 mmol). Once the reaction was complete, the mixture was evaporated under reduced pressure and the remaining solid/oil was extracted with Et2O (x5). The ether extracts were evaporated under reduced pressure to give the crude aldehyde. Purification by silica gel chromatography afforded the desired aldehyde 4-1. 105 WO 2006/002236 PCT/US2005/022062 [0231] To a stirred solution of (R)-amine 2-5 (2.0 mmol) and aldehyde 4-1, (2.2 mmol) in CH2Cl2 (20 ml) was added AcOH (2.0 mmol) followed by the addition of sodium tris-acetoxyborohydride (3.0 mmol). After 19 h, further sodium tris-acetoxyborohydride (1.0 mmol) was added. Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between EtOAc and 1M NaOH. The organics were separated, then washed with 1M NaOH (x2), H2O (xl), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give crude product. Purification by silica gel chromatography affored the amine 4-2 as a mixture of (R,R) and (R,S) diastereomers. 106 WO 2006/002236 PCT/US2005/022062 [0232] To a solution of (R) amine 4-2 (0.069 mmol) in THF (0.5 ml) was added DIPEA (0.138 mmol) followed by l,5-dimethyl-lH-pyrazole-3-carbonyl chloride (0.076 mmol). The mixture was heated at 50°C. Once the reaction was complete, the mixture was concentrated in vacuo, and then purified by reverse phase prep. HPLC which separated the (R,R) 4-4 and the (R,S) 4-3 diastereomers. [0233] Boc-protected amine 4-3 (0.004 mmol) was treated with 10% TFA/ CH2Cl2 (1 ml). Once the reaction was complete, the reaction was evaporated under reduced pressure and purified by reverse phase prep. HPLC to give the pure Compound 257 in Table 2. 107 WO 2006/002236 PCT/US2005/022062 Compound 258 (not shown) in Table 2 was synthesized using similar procedures usning 47 as starting material in Step D. [0234] To a stirred solution of amino alcohol 5-1 (0.96 mmol) in DMF (0.4 ml) was added imidazole (0.482 mmol), DMAP (catalytic amount) and TMSC1. Once the reaction was complete, the mixture was partitioned between EtOAc and sat. aqueous NaHCO3. The organics were separated, then washed with sat. aqueous NaHCO3 (x2), H2O (xl), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give crude product. Purification by silica gel chromatography afforded the silyl ether 5-2. 108 WO 2006/002236 PCT/US2005/022062 [0235] To a solution of silyl ether 5-2 (0.073 mmol) in CH2C12 (0.8 ml) was added DIPEA (0.876 mmol) followed by phosgene (0.584 mmol). Once the reaction was complete, the mixture was concentrated in vacuo, and then purified by reverse phase prep. HPLC to give the pure spiro compound 5-3 as a mixture of (R,R) and (R,S) diastereomers. [0236] Boc-amine 5-3 (0.0135 mmol) was treated with 10% TFA/ CH2C12 (0.3 ml). Once reaction was complete, the reaction was evaporated under reduced pressure and purified by reverse phase prep. HPLC to give the separated 320 (R,R) and 319 (R,S) diastereomers. 109 WO 2006/002236 PCT/US2005/022062 [0237] A stirred solution of D-Boc-Valine (4.605 mmol) in EtOH (10 ml) was treated with CS2CO3 (0.75g, 2.30 mmol). After 45 min, the EtOH was removed by evaporation under reduced pressure. The residual cesium salt was re-dissolved in DMF (15 ml) and the treated with 2-bromoacetophenone (0.916g, 4.605 mmol) and stirred at room temperature until the reaction was complete. The reaction mixture was then partitioned between EtOAc and H2O, and the organics separated, then washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the keto-ester 6-1 which was pure enough to use directly in the next step. [0238] To a stirred solution of the product from Step A keto ester 6-1(1.589g, 4.743 mmol) in xylenes (50 ml) was added ammonium acetate (1.82g, 23.7 mmol). A Dean- 110 WO 2006/002236 PCT/US2005/022062 Stark trap was added and the reaction heated to 140°C. Once the reaction was complete, the mixture was allowed to cool to room temperature, then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole 6-2 which was pure enough to use directly in the next step. [0239] To a stirred solution/ suspension of the product from Step B compound 6-2 (l.00g, 3.17 mmol) and K2CO3 (0.876g, 6.34 mmol) in DMF (10 ml) was added benzyl bromide (0.415 ml, 3.49 mmol). Once the reaction was complete, the mixture was partitioned between EtOAc and H2O. The organic layer was separated and washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude benzylated phenyl imidazole. The crude reaction material was then crystallized (EtOAc, hexanes) to give pure product compound 6-3. The regiochemical outcome was verified by 1H nOeNMR. Ill WO 2006/002236 PCT/US2005/022062 [0240] Boc-protected amine compound 6-3 from Step C (0.406g, 1.0 mmol) was treated with 10% TFA in CH2Cl2 (5 ml). Once reaction was complete, the reaction was concentrated in vacuo and then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat aq. NaHCO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole free amine compound 6-4 which was pure enough to use directly in the next step. [0241] To a stirred solution of amine 6-4 from Step D (59mg, 0.193 mmol) and 2-(3-oxopropyl)benzo[c]azoline-l,3-dione (39mg, 0.193 mmol) in CH2C12 (1.5 ml) was added AcOH (11 pL, 0.193 mmol). The mixture was allowed to stir for 5 min before the addition of 112 WO 2006/002236 PCT/US2005/022062 sodium tris-acetoxyborohydride (45mg, 0.212 mmol). After lh, the mixture was concentrated in vacuo, partitioned between EtOAc and 2 M aq. Na2CO3. The organics were separated, then washed with 2 M aq. Na2CO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 6-5 which was pure enough to use directly in the next step. [0242] To a stirred solution of amine 6-5 from Step E (42mg, 0.085mmol) in CH2C12 (1.2 ml) was added DIPEA (30 µL, 0.170 mmol) followed byp-toluoyl chloride (12.4 L, 1.0 mmol). Once the reaction was complete, the mixture was partitioned between CH2Cl2 and sat. aq. NaHCO3. The organics were separated and washed with H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 6-6 which was pure enough to use directly in the next step. 113 WO 2006/002236 PCT/US2005/022062 [0243] To a non-stirred solution of phthalimido compound 6-6 from step F, (52mg, 0.085 mmol) in EtOH (1.5 ml) was added anhydrous hydrazine (26 µL, 0.85 mmol). Once the reaction was complete, the reaction was filtered, and the filtrate evaporated under reduced pressure to give the title compound which was purified by reverse phase prep. HPLC to give the pure product 1 in Table 1. [0244] A stirred solution of the N-Boc-acid (10.0 g, 43.2 mmol 1.0 eq.) in EtOH (150 ml) was treated with Cs2CO3 (7.04 g, 21.6 mmol, 0.5 eq.). After 45 min, the EtOH 114 WO 2006/002236 PCT/US2005/022062 was removed by evaporation under reduced pressure. The residual cesium salt was re-dissolved in DMF (150 ml) and the treated with 2-bromoacetophenone (8.60 g, 43.2 mmol, 1.0 eq.) and stirred at room temperature for 1 hour. The reaction mixture was then partitioned between EtOAc and H2O, and the organics separated, then washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the keto-ester 2-2 which was pure enough to use directly in the next step. [0245] To a stirred solution of keto-ester 2-2 from Step A (15.1 g, 43.2 mmol, 1.0 eq.) in xylenes (500 ml) was added ammonium acetate (16.6 g, 216.2 mmol, 5.0 eq.). A Dean-Stark trap was added and the reaction heated to 140°C for 1 hour. Once the reaction was complete, the mixture was allowed to cool to room temperature, then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole 2-3 which was pure enough to use directly in the next step. 115 WO 2006/002236 PCT/US2005/022062 [0246] To a stirred solution/ suspension of imidazole 2-3 from Step B (14.26 g, 43.2 mmol, 1.0 eq.) and K2CO3 (12.00 g, 86.4 mmol, 2.0 eq.) in DMF (150 ml) was added the benzyl bromide (5.65 ml, 47.53 mmol, 1.1 eq.). The reaction was stirred at room temperature for 12 hours. Once the reaction was complete, the mixture was partitioned between EtOAc and H2O. The organic layer was separated and washed with H2O (x3), brine (x3), then dried (Na2SC>4), filtered, and evaporated under reduced pressure to give the crude benzylated phenyl imidazole 2-4, which was pure enough to move directly onto the next step. [0247] Boc-protected amine 2-4 from Step C (5.0 g, 11.93 mmol) was treated with 15% TFA in CH2Cl2 (35 ml). Once reaction was complete, the reaction was concentrated in 116 WO 2006/002236 PCT/US2005/022062 vacuo and then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole free amine 2-5 which was pure enough to use directly in the next step. [0248] To a stirred solution of amine 2-5 from Step D (1.00 g, 3.13 mmol, 1.0 eq.) and the 2-(3-oxopropyi)benzo[c]azoline-l,3-dione 25 (0.51 g, 2.51 mmol, 1.0 eq.) in CH2Cl2 (10 ml) was added AcOH (0.18 ml, 3.13 mmol, 1.0 eq.). The mixture was allowed to stir for 5 min before the addition of sodium tris-acetoxyborohydride (0.73 g, 3.44 mmol, 1.1 eq.). Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between EtOAc and 2 M aq. Na2CO3. The organics were separated, then washed with 2 M aq. Na2CO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 7-1 which was pure enough to use directly in the next step. 117 WO 2006/002236 PCT/US2005/022062 [0249] To a stirred solution of amine 7-1 from Step E (0.04 g, 0.08 mmol, 1.0 eq.) in CH2C12 (0.3 ml) was added the acid (0.024 g, 0.17 mmol, 2.2 eq.), HOAT (0.24 g, 0.17 mmol, 2.2 eq.), and TEA (0.05 ml, 0.33 mmol, 4.2 eq.). After 5 minutes EDC (0.04 g, 0.18 mmol, 2.3 eq.) was added, and the reaction was heated to 55°C for 24 hours. The mixture was then partitioned between CH2Cl2 and sat aq. NaHCO3. The organics were separated and washed with H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 7-2. 118 WO 2006/002236 PCT/US2005/022062 [0250] To a non-stirred solution of phthalimido compound 7-2 from Step F (0.02 g, 0.03 mmol, 1.0 eq.) in EtOH (0.1 ml) was added anhydrous hydrazine (0.005 g, 0.15 mmol, 5.0 eq.). Once the reaction was complete, the reaction was filtered, and the filtrate evaporated under reduced pressure to give the title compound which was purified by reverse phase prep. HPLC to give the pure product 99. 119 WO 2006/002236 PCT/US2005/022062 [0251] A stirred solution of the N-Boc-acid (8.0 g, 36.8 mmol 1.0 eq.) in EtOH (130 ml) was treated with CS2CO3 (6.0 g, 18.4 mmol, 0.5 eq.). After 45 min, the EtOH was removed by evaporation under reduced pressure. The residual cesium salt was redissolved in DMF (130 ml) and the treated with chloro-subtituted 2-bromoacetophenone (8.60 g, 36.84 mmol, 1.0 eq.) and stirred at room temperature for 1 hour. The reaction mixture was then partitioned between EtOAc and H2O, and the organics separated, then washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the keto-ester 8-lwhich was pure enough to use directly in the next step. 120 WO 2006/002236 PCT/US2005/022062 [0252] To a stirred solution of keto-ester 8-1 from Step A (13.5 g, 36.8 mmol, 1.0 eq.) in xylenes (450 ml) was added ammonium acetate (14.2 g, 185.0 mmol, 5.0 eq.). A Dean-Stark trap was added and the reaction heated to 140°C for 1 hour. Once the reaction was complete, the mixture was allowed to cool to room temperature, then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole 8-2 which was pure enough to use directly in the next step. [0253] To a stirred solution/ suspension of imidazole 8-2 from Step B (12.85 g, 36.8 mmol, 1.0 eq.) and K2CO3 (10.17 g, 73.6 mmol, 2.0 eq.) in DMF (122 ml) was added the benzyl bromide (5.20 ml, 40.49 mmol, 1.1 eq.). Reaction was stirred at room temperature for 12 121 WO 2006/002236 PCT/US2005/022062 hours. Once the reaction was complete, the mixture was partitioned between EtOAc and H2O. The organic layer was separated and washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude benzylated phenyl imidazole 8-3, which was pure enough to move directly onto the next step. [0254] Boc-protected amine 8-3 from Step C (5.0 g, 11.40 mmol) was treated with 15% TFA in CH2Cl2 (35 ml). Once reaction was complete, the reaction was concentrated in vacuo and then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole free amine 8-4 which was pure enough to use directly in the next step. 122 WO 2006/002236 PCT/US2005/022062 [0255] To a stirred solution of amine 8-4 from Step D (3.86 g, 11.40 mmol, 1.0 eq.) and 2-(3-oxopropyl)benzo[c]azoline-l,3-dione (2.31 g, 11.40 mmol, 1.0 eq.) in CH2Cl2 (40 ml) was added AcOH (0.65 ml, 11.40 mmol, 1.0 eq.). The mixture was allowed to stir for 5 min before the addition of sodium tris-acetoxyborohydride (2.65 g, 12.52 mmol, 1.1 eq.). Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between EtOAc and 2 M aq. Na2CO3. The organics were separated, then washed with 2 M aq. Na2CO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 8-5 which was pure enough to use directly in the next step. 123 WO 2006/002236 PCT/US2005/022062 [0256] To a stirred solution of amine 8-5 from Step E (0.05 g, 0.10 mmol, 1.0 eq.) in CH2C12 (0.3 ml) was added the acid (0.02 g, 0.11 mmol, 1.0 eq.), HOAT (0.15 g, 0.10 mmol, 1.0 eq.), and TEA (0.03 ml, 0.20 mmol, 2.1 eq.). After 5 minutes EDC was added (0.22 g, 0.20 mmol, 2.0 eq.), and the reaction was heated to 55°C for 24 hours. The mixture was then partitioned between CH2Cl2 and sat. aq. NaHCO3. The organics were separated and washed with H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 8-6. 124 WO 2006/002236 PCT/US2005/022062 [0257J To a non-stirred solution of phthalimido compound 8-6 from Step F (0.01 g, 0.02 mmol, 1.0 eq.) in EtOH (0.6 ml) was added anhydrous hydrazine (0.003 g, 0.10 mmol, 5.0 eq.). Once the reaction was complete, the reaction was filtered, and the filtrate evaporated under reduced pressure to give the title compound which was purified by reverse phase prep. HPLC to give the pure product 71. Example 9 Synthesis of intermediate (3R, 4S)-tert-buiyl 3-fonnyl-4-hydroxypyrrolidin-l-carboxylate [0258] The title compound is useful as an intermediate in synthesizing compounds of the invention. 125 WO 2006/002236 PCT/US2005/022062 [0259] 5.0 g (29.5 mmol) of tert-Butyl 2,5-dihydro-lH-pyrrole-l-carboxylate and 11.7 g (67.9 mmol) 3-chloroperoxybenzoic acid were stirred in 70 ml of DCM under nitrogen at ambient temperature for 20 hours. Excess 1N NaOH was added to the reaction mixture and the resulting solution was extracted using DCM (3x). The organic layers were combined, dried over MgSO4, and the solvent was removed in vacuo yielding 5.2 g (28.1 mmol, 95%) of 9-1 as a yellow oil. [0260] 4.3 g (23.3 mmol) of compound 9-1 and 0.21 g (2.33 mmol) CuCN in 50 ml anhydrous THF were cooled to -78 °C. Vinyl magnesium bromide (73.3 mmol) was added drop wise and the resulting solution was allowed to warm to ambient temperature during the course of 7 hours. The reaction was monitored by thin-layer chromatography and the product was eluted using 1:2 ethyl acetate and hexanes and staining with ninhydrin. The reaction was quenched with saturated NH4Cl and extracted with ethyl acetate (3X). The combined organic 126 WO 2006/002236 PCT/US2005/022062 layers were dried over MgSO4 and the solvent was removed in vacuo yielding 4.75 g (22.3 mmol, 96%) of 9-2 as a tan oil. [0261] 2.0 g (9.4 mmol) of 9-2 was dissolved in 20 ml THF and 10 ml H2O followed by the addition of 3.51 g (16.4 mmol) NaIO4 and 0.23 ml osmium tetroxide. The reaction was stirred at ambient temperature under nitrogen yielding a white precipitate after 30 minutes. The reaction was monitored by thin-layer chromatography and the product was eluted using 1:1 ethyl acetate and hexanes and staining with ninhydrin. The reaction was complete after approximately 8 hours. Excess H2O was added to the reaction mixture and the resulting solution was extracted using ethyl acetate (3X). The combined organic layers were washed with saturated NaHCO3 and brine, dried over MgSO4, and the solvent was removed in vacuo yielding 1.35 g (6.3 mmol, 67%) of 9-3 as a tan foam. [0262] Compound 297,298,299,300,307,308,309,310,326, and 327 were synthesized using similar procedures as in Example 6,7, and 8 using intermediate 9-3 as intermediate in reductive amination step. 127 WO 2006/002236 PCT/US2005/022062 [0263] To a stirred solution of Boc-L-?-homoasparagine 10-1 (8.0 mmol) and ethane thiol (16 mmol) in DMF (10 ml) was added 1,3-dicyclohexylcarbodimide (8.8 mmol) and DMAP (0.8 mmol). The reaction was stirred at room temperature until tine reaction was complete. The precipitate was filtered and washed with ethyl acetate. The organics were combined and concentrated. Separation on a silica gel column with ethyl acetate gave the desired thioester 10-2. 128 WO 2006/002236 PCT/US2005/022062 [0264] To a stirred mixture of ethyl thio ester 10-2 (0.1 mmol) and 10% Pd on carbon (20 mol%) in acetone (1 ml) was added Et3SiH (4.4 mmol) at room temperature under an argon atmosphere. Stirring was continued at room temperature until the reduction was complete in about 30 min. The catalyst was filtered off through Celite and washed with acetone. Evaporation under reduced pressure produced aldehyde 10-3, which was use directly in the next step. [0265] To a stirred solution of amine 2-5, from Example 2 above (1.0 mmol) in CH2Cl2 was added appropriate aldehyde 10-3 (1.0 mmol) (7 ml). The mixture was allowed to stir for 5 min before the addition of sodium tris-acetoxyborohydride (1.0 mmol). Once the reaction was complete, the mixture was concentrated in vacua, partitioned between EtOAc and 2M aq. Na2CO3. The organics were separated, then washed with 2M aq. Na2CO3 (x2), H2O (x2), 129 WO 2006/002236 PCT/US2005/022062 brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 10-4 which was used directly in the next step. [0266] To a stirred solution of amine 10-4 (1.0 mmol) in CH2Cl2 (6 ml) was added Et3N (2.0 mmol), DMAP (10.1 mmol) followed by benzoyl chloride (1.0 mmol). Once the reaction was complete, the mixture was partitioned between CH2Cl2 and sat. aq. NaHCO3. The organics were separated and washed with H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give product 10-5, which was further purified by reverse phase HPLC. 130 WO 2006/002236 PCT/US2005/022062 [0267] The Boc protected compound 10-5 was treated with HC1 in dioxane (4N, 10 eq.) for 30 min, and the solvent was removed to give the final product 100 as HC1 salt. [0268] Using the similar procedures to make the thiol ester from 3-(lH-imidazole-2-yl)-propionic acid, then reduced to the aldehyde. Reductive amination followed by acylation to form the final compound 113 as shown in the following scheme. 131 WO 2006/002236 PCT/US2005/022062 [0269] Compound 11-2 was synthesized in a matter similar to that described in Example 10, steps A and B. [0270] Compound 11-4 was synthesized using procedures similar to that in Example 10, steps C, D, and E. 132 WO 2006/002236 PCT/US2005/022062 [0271J A stirred solution of the appropriate N-Boc-acid, e.g. N-Boc-Glycine (0.15 mmol) and phenylimidazole amine compound 23 (0.1 mmol) in THF (3 ml) was treated with PyBOP (0.15 mmol) and Et3N (0.3 mmol). Compound 23 was prepared using the method described in Example 1. The reaction was stirred at room temperature until the completion, and was evaporated under reduced pressure. Purification by silica gel column to give the protecte amine 12-1. 133 WO 2006/002236 PCT/US2005/022062 [0272] The Boc protected compound 12-1 was treated with HC1 in dioxane (4N, 10 eq.). Once the reaction was complete, the solvent was removed to give the final product, compound 101, which was purified by reverse phase prep. HPLC. [0273] The following compounds were synthesized using the the similar procedures: 134 WO 2006/002236 PCT/US2005/022062 [0274] To a stirred solution of amine 23 (0.1 mmol) was added appropriate aldehyde, e.g., glyoKylic acid (0.1 mmol) in CH2Cl2 (1 ml). The mixture was allowed to stir for 5 min before the addition of sodium tris-acetoxyborohydride (0.1 mmol). Once the reaction was complete, the mixture was concentrated and purified by reverse phase prep. HPLC to get the title compound 13-1 as TFA salt. [0275] The following compounds were prepared by this procedure: 136 WO 2006/002236 PCT/US2005/022062 [0276] DL-?-Aminoadipic acid hydrate 14-1 (2 g, 11 mmol) was dissolved in 2 M NaOH (11 ml, 22 mmol). Benzaldehyde (1.4 ml, 11 mmol) was dissolved in 3.0 ml of ethanol and this solution was added to the first solution. After 10 minutes the mixture was cooled to 0°C and sodium borohydride (0.13 g, 3.3 mmol) was added. After 1 hour, the reaction was complete as monitored by LCMS. The solution was extracted 3 times with 20 ml portions of ether, cooled to 0°C, acidified to pH 2 with concentrated HC1 and the resulting precipitate was filtered to afford a white solid. The solid was washed once with a minium amount of acetonitrile (1 ml) and three times with ether. The crude solid was dissolved in 55 ml ethanol and the solution was refluxed overnight. The solution was evaporated to provide the lactam product 14-2. 137 WO 2006/002236 PCT/US2005/022062 [0277] A stirred solution of the lactam acid 14-2 (4.0 mmol) in EtOH (10 ml) was treated with CS2CO3 (2.0 mmol). After 45 min, the EtOH was removed by evaporation under reduced pressure. The residual cesium salt was re-dissolved in DMF (15 ml) and the treated with 2-bromoacetophenone (4.0 mmol) and stirred at r.t. until the reaction was complete. The reaction mixture was men partitioned between EtOAc and H2O, and the organics separated, washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure. The residue was purified by silica gel column to afford the keto ester 14-3. [0278] To a stirred solution of keto-ester 14-3 (4.0 mmol) in xylenes (40 ml) was added ammonium acetate (20 mmol). A Dean-Stark trap was added and the reaction heated to 140°C. Once the reaction was complete, the mixture was allowed to cool to r.t., then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed 138 WO 2006/002236 PCT/US2005/022062 with sat. aq. NaHCO3 (x2), H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the phenyl imidazole which was purified on a silica gel column to get the title compound 14-4. [0279] To a stirred suspension of imidazole 14-4 (4.0 mmol) and K2CO3 (8.0 mmol) in PMF (10 ml) was added the benzylating agent, benzyl bromide (4.40 mmol). Once the reaction was complete, the mixture was partitioned between EtOAc and H2O. The organic layer was separated and washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude benzylated phenyl imidazole 114. The crude reaction material was then purified by silica gel column or reverse phase HPLC. The following compound was also prepared by using a similar procedure. 139 WO 2006/002236 PCT/US2005/022062 Example 15 Preparation of N-(3-Amino-propyl)-N-{l-[l-(3-fluoro-benzyI)-4-(3-fluoro-phenyl)-lH-imidazoI-2-yl]-l-methyl-ethyl}-2-methoxy-acetamide (compound 393) Step A: Synthesis of (tert-butoxy)-N-{l-[4-(3-fluorophenyI)-imidazol-2-yl]- isopropyl}carboxamide [0280] To 2-[(tert-butoxy)carbonylamino]-2-methylpropanoic acid (1 eq.) in N,N-dimethylformamide was added ammonium carbonate (1 eq.) and the mixture was heated to 110°C for 10 min. The reaction mixture was cooled to 60°C and to it was added 2-bromo-l-(3-fluorophenyl)ethan-l-one (0.2 eq.) and the mixture was heated to 125°C for 3h. LCMS showed the formation of (tert-butoxy)-N-{l-[4-(3-fluorophenyl-imidazol-2-yl]-isopropyl}carboxamide. The reaction mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was separated and washed with saturated sodium chloride solution and dried with sodium sulfate. The resulting crude was purified by silica gel chromatography to give (tert-butoxy)-N-{l-[4-(3-fluorophenyl-imidazol-2-yl]-isopropyl}carboxamide. [0281] MS: MH+= 320. Step B: Synthesis of (tert-butoxy)-N{l-[4-(3-fluorophenyl-l-[(3-fluorophenyl)methyl]imidazoI-2-yl]-isopropyl}carboxamide [0282] To a stirred solution/ suspension of (tert-butoxy)-N-{l-[4-(3-fluorophenyl-imidazol-2-yl]-isopropyl}carboxamide (1 eq.) and potassium carbonate (2 eq.) in N,N-dimethylformamide was added l-(bromomethyl)-3-fluorobenzene (1.1 eq.). Once the reaction was complete, the mixture was partitioned between ethyl acetate and water. The organic layer was separated and washed with water, saturated sodium chloride solution, then dried with 140 WO2006/002236 PCT/US2005/022062 sodium sulfate, filtered, and evaporated under reduced pressure to give the crude benzylated phenyl imidazole. The crude reaction material was purified by silica gel chromatography. [0283] MS:MH+=428. Step C: Synthesis of 2-{4-(3-fluorophenyl}-l-[(3-fluorophenyl)methyI]imidazoI-2-yl}prop- 2-yI-amine [0284] To (tert-butoxy)-N{l-[4-(3-fluorophenyl-imidazol-2-yl]- isopropyl}carboxaimide (1 eq.) was added 10% trifluoroacetic acid in methylene chloride. Once the reaction was complete the mixture was concentrated and partitioned between saturated sodium carbonate and ethyl acetate. The organic layer was separated and washed with water saturated sodium chloride solution, then dried with sodium sulfate, filtered, and evaporated under reduced pressure to give 2-{4-(3-fluorophenyl}- l-[(3-fluorophenyl)methyl]imidazol-2-yl}prop-2-yl-amine. [0285] MS: MH+ = 328. Step D: Synthesis of 2-{3-[(l-{4-(3-fluorophenyl)-l-[(3-fluorophenyI)methyI]imidazoI-2-yI}-isopropyl)amino]propyl}benzo[C]azoline-l,3-dione [0286] To a stirred solution of 2-{4-(3-fluorophenyl}-l-[(3-fluorophenyl)methyl]imidazol-2-yl}prop-2-yl-amine amine (1 eq.) and 2-(3-oxopropyl)benzo[C]azoline-l,3-dione(l eq.) in methylene chloride at 0°C was added acetic acid (1 eq.) followed by the addition of sodium tris-acetoxyborohydride (1.5 eq.). Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between ethyl acetate and , saturated sodium bicarbonate solution. The organic layer was separated and washed with saturated bicarbonate and water followed by saturated sodium chloride solution, then dried with 141 WO 2006/002236 PCT/US2005/022062 sodium sulfate, filtered, and evaporated under reduced pressure to give crude product which was purified by silica gel chromatography. [0287] MS:MH+=515. Step E: Synthesis of N-[3-(l,3-dioxobenzo[C]azoline-2-yl)propyl]-N-(l-{4-(3-fluorophenyI}-l-[3-fluorophenyI)methyl]imidazol-2-yl}-isopropyI)-2-raethoxyacetamide [0288] To a stirred solution of 2-{(lS)-l-(fluoromethyl)-3[(l-{4-(3-fluorophenyl)-l-[(3-fluorophenyI)methyl]imidazol-2-yl}- isopropyl)amino]propyl}benzo{C}azoline-l,3-dione) (1 eq,)in methylene chloride was added methoxy acetylchloride (3 eq.) and triethylamine (3 eq.)- Once the reaction was complete, the mixture was concentrated in vacuo, partitioned between ethyl acetate and saturated sodium bicarbonate solution. The organic layer was separated and washed with saturated bicarbonate and water followed by saturated sodium chloride solution, then dried with sodium sulfate, filtered, and evaporated under reduced pressure to give N-[3-(l,3-dioxobenzo[C]azline-2-yl)propyl]-N-(l-{4-(3-fluorophenyl}-l-[3-fluorophenyl)methyl]imidazol-2-yl}-isopropyl)-2-methoxyacetamide [0289] MS: MH+ = 587. Step F: Synthesis of N-(3-Amino-propyI)-N-{l-[l-(3-fluoro-benzyI)-4-(3-fluoro-phenyl)-lH-imidazoI-2-yl]-l-methyl-ethyl}-2-methoxy-acetamide [0290] To a stirred solution of 2-{(lS)-l-(fluoromethyl)-3[(l-{4-(3-fluorophenyl)-l-[(3-fJuorophenyl)methyl]imidazol-2-yl}- isopropyl)amino]propyl}benzo{C}azoline-l,3-dione) in ethanol was added hydrazine (1.5 eq.). Once the reation was complete it was filtered and the filtrate was evaporated under reduced 142 WO 2006/002236 PCT/US2005/022062 pressure. It was purified on preparative HPLC to give N-(3-Amino-propyl)-N-{ 1 -[1 -(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-1 H-imidazol-2-yl]-1 -methyl-ethyl} -2-methoxy-acetamide [0291] MS: Mit « 457. Example 16 Alternate Preparation of N- ((S)-3-amino-4-methoxybiityI)-N- ((R)-l-(l-benzyI-4- (2,5-difluorophenyl)-lH-imidazol-2-yl)-2,2-dimethyIpropyI)-2-methoxyacetamide (Compound 422) Step A: Synthesis of tert-butyl (S)-l-((benzyIoxy) carbonyl) -3-methoxypropan-2- ylcarbamate [0292] To tert-butyl (S)-l-((benzyloxy)carbonyl)-3-hydroxypropan-2-ylcarbamate (1 eq.) in dichloromethane was added 2,6-di-t-butyl 4-methylpyridine (2.5 eq.) and tnmethyloxonium tetrafluoroborate (1.25 eq.) at 0°C. The reaction mixture was gradually warm to room temperature and stirred overnight. The reaction mixture was diluted with dichloromethane and washed with cold satd. sodium bicarbonate, water, and brine and dried over sodium sulfate. Purification by silica gel chromatography (25% EtOAc / Hexane) provide pure product as a colorless viscous liquid. [0293] MS: MH+ = 324.1 Step B: Synthesis of tert-butyl (S)-l-formyl-3-methoxypropan-2-ylcarbamate [0294] Azeotrope tert-butyl (S)-l-((ben2yloxy) carbonyl)-3-methoxy propan-2- ylcarbamate (1 eq.) with toluene (x=3). Dissolved in dichloromethane and cooled to -78°C. To then was added drop wise 1 M solution of DIBAL in toluene (2 eq.) under N2 atmosphere and stirred at -78°C for 2h. The reaction was quenched with methanol and concentrated. To concentrated residue was added 2 M potassium sodium tartrate solution at 0°C and stirred 143 WO 2006/002236 PCT/US2005/022062 vigorously at room temperature for 30 min. Partitioned between ethyl acetate and water. The organic layer was washed with brine and dried over sodium sulfate. Filtered, evaporated and dried under high-pressure vacuum to provide product as a colorless viscous liquid. [0295] MS: MH+=218.2 Step C: Synthesis of tert-butyl (S)-4-((R)-l-(l-benzyI-4- (2,5-difluorophenyl)-lH-imidazol-2-yl)-2^-dimethylpropylamino)-l-methoxybutan-2-ylcarbamate [0296] To (R)-l-(l-benzyl-4- (2,5-difluorophenyl)-lH-imidazol-2-yl)-2,2-dimethylpropan-1-amine (leq) in dichloromethane was added tert-butyl (S)-l-formyl-3-methoxypropan-2-ylcarbamate (1.5eq) and acetic acid (leq). The reaction mixture was stirred at room temperature for lh. Sodium triacetoxy borohydride (2eq) was added at 0°C. The reaction mixture was warmed to room temperature and stirred overnight. Solvent was concentrated and crude was partitioned between ethyl acetate and satd. sodium bicarbonate. The organic layer was washed with water, brine and dried over sodium sulfate. Purification by silica gel chromatography (25% EtOAc / Hexane) provide pure product as a white foamy solid. [0297] MS: MH+ = 557.2 Step D: Synthesis of tert-butyl (S)-4-((R)-l-(l-benzyl-4- (2,5-di£luorophenyl)-lH-iinidazol-2-yl)-2,2-dimethylpropyl)-2-methoxyacetamido)-l-methoxybutan-2-yIcarbamate [0298] To tert-butyl (S)-4-((R)-l-(l-benzyl-4- (2,5-difluorophenyl)-lH-imidazol-2-yl)-2,2-dimethylpropylamino)-l-methoxybutan-2-ylcarbamate (leq.) in THF was added triethylamine (2 eq.) and methoxyacetalchloride (10 eq.). Stirred at room temperature for 30min. The reaction mixture was diluted with ethyl acetate and washed with water and brine. Dried over sodium sulfate. Filtered, evaporated and dried under reduced pressure to provide product as a colorless semi solid. 144. WO 2006/002236 PCT/US2005/022062 [0299] MS: MH+ = 629.2 Step E: Synthesis of N- ((S)-3-amido-4-methoxybutyl)-N- ((R)-l-(l-benzyl-4- (2,5-difluorophenyl)-lH-imidazol-2-yl)-2,2-dimethylpropyl)-2-methoxyacetamide [0300] To tert-butyl (S)-4-((R)-l-(l-benzyl-4- (2,5-difluorophenyl)-lH-imidazol-2-yl)-2,2-dimethylpropyl)-2-methoxyacetamido)-1 -methoxybutan-2-ylcarbamate was added 30% TFA / DCM. Stirred at room temperature for lh. Solvent was evaporated. Purification by preparative chromatography provide product as a white solid. [0301] MS: MH+ =529.1 Example 17 Preparation of Intermediate (R)-l-(l-benzyl-4-(pyrazin-2-yl)-lH-imidazoI-2-yl)-2,2- dimethylpropan-1-amine [0302] This intermediate is useful in preparing compounds of the invention which have pyrazine substituent, such as Compound 328,331 and the like. [0303] To a stirred solution of acetylpyrazine 17-1 (24.6 mmol) and TMSC1 (24.6 mmol) in THF (12.3 ml) in a -78 °C acetone/dry ice bath was added LiHMDS (24.6 mmol, 1.0 M solution in THF) dropwise via an addition runnel. After 90 min, the reaction was allowed to warm to r.t. To the reaction was added cold EtOAc and the organics were washed with sat. 145 WO 2006/002236 PCT/US2005/022062 aq. NaHCO3 (x3) and cold brine (xl), then dried (Na2SO4), filtered, and concentrated in vacuo to provide a yellow liquid. The liquid was purified via flash chromatography (5% EtOAc/hexanes) to give 85% pure product 17-2 (remaining 15% as starting pyrazine). [0304] To a stirred solution of TMS enol ether 17-2 (6.5 mmol) in cold pentane (15.2 ml), was added a solution of bromine (6.8 mmol) in pentane (5.3 ml) dropwise. After lh, the reaction was diluted with EtOAc. The organics were washed with sat. aq. NaHCO3 (x3) and brine (xl), dried (Na2SO4), filtered, and evaporated under reduced pressure to give a brown solid. [0305] A stirred solution of tert-butyl leucine 2-1 (4.5 mmol), in EtOH (15 ml) was treated with CS2CO3 (2.25 mmol). After 45 min, the EtOH was removed by evaporation under reduced pressure. The residual cesium salt was re-dissolved in DMF (15 ml) and the treated with the ?-bromo ketone 17-3 (4.5 mmol) and stirred at room temperature until the reaction was complete. The reaction mixture was then partitioned between EtOAc and H2O, and 146 WO 2006/002236 PCT/US2005/022062 the organics separated, then washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the keto-ester 17-4 which was pure enough to use directly in the next step. [0306] To a stirred solution of keto-ester 17-4 (4.4 mmol) in xylenes (44 ml) was added ammonium acetate (22 mmol). A Dean-Stark trap was added and the reaction heated to 140°C. Once the reaction was complete, the mixture was allowed to cool to r.t, then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the pyrazine-imidazole 17-5 which was pure enough to use directly in the next step. [0307] To a stirred solution/ suspension of imidazole 17-5 (0.9 mmol) and K2CO3 (1.8 mmol) in DMF (3 ml) was added benzyl bromide (0.95 mmol). Once the reaction 147 WO 2006/002236 PCT/US2005/022062 was complete, the mixture was partitioned between EtOAc and H2O. The organic layer was separated and washed with H2O (x3), brine (x3), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the crude benzylated imidazole. The crude reaction material was then purified via flash chromatography (15% EtOAc/hexanes) to give pure product 17-6. [0308] Boc-protected amine 17-6 (0.5 mmol) was treated with 20% TFA in CH2Cl2 (5 ml). Once reaction was complete, the reaction was concentrated in vacuo and then partitioned between EtOAc and sat. aq. NaHCO3. The organics were separated, then washed with sat. aq. NaHCO3 (x2), H2O (x2), brine (x2), then dried (Na2SO4), filtered, and evaporated under reduced pressure to give the imidazole free amine 17-7 which was pure enough to use as an intermediate in synthesizing compounds of the invention with the pyrazine substitution. 148 WO 2006/002236 PCT/US2005/022062 Example 18 Preparation for Intermediate of [3-Fluoro Aldehyde Side Chain [0309] To a stirred solution of anhydrous K2CO3 (46.53 g, 0.3371 mol) in N,N-dimethylformamide (500 ml), D-serine methyl ester hydrochloride (35.0 g, 0.2250 mol), KI (18.66 g, 0.1124 mol) and benzyl bromide (96.18 g, 0.5623 mol) were added in one shot. The reaction mixture was stirred vigorously for 5h at room temperature. After completion of reaction, contents were poured into ice water and extracted with ethyl acetate. The combined organic layer was washed with water, brine, dried over Na2SO4 and concentrated to give a crude product 18-2. Purification was carried out by column chromatography to yield pure (61,7g, 91.7%) as pale yellow oil. 149 'WO 2006/002236 PCT/US2005/022062 [0310] To a stirred solution of diethylamine sulphur trifluoride (32.3 ml, 0.2006 mol) in THF (400 ml), alcohol (100.0 g, 0.3344 mol) in THF (400 ml) was added dropwise compound 18-2 during the span of 3h at room temperature. After completion of addition, stirring was continued for further lh. The mixture was extracted with ethylacetate and combined organic phase was washed with saturated solution of NaHCO3. Removal of solvent under vacuum lead to a crude product, which was purified by column chromatography using hexane grading to 3% EtOAc in hexane afforded product 18-3 (70.4g, 69.9%) as pale yellow oil. [0311] To a mechanically stirred solution of LiBH4 (230.8 ml, 0.4651 mol) in THF (2.0 L), methyl ester (100.0 g, 0.3322 mol) in THF (1.0 L) was added dropwise 18-3 through addition funnel during the span of 3h at -15°C under N2. After the completion of addition, stirring was continued for 4h at room temperature. Saturated solution of NH4Cl (500ml) was added dropwise to the above mixture and extracted with EtOAc. The combined organic phase was washed with water, brine, dried over Na2SO4 and concentrated under vacuum. 150 WO 2006/002236 PCT/US2005/022062 Residual oil was dissolved in 1N HC1 (200 ml), extracted with diethylether and pH of the aqueous layer was adjusted to 10 with the help of NH4OH (50%, 300ml). The resultant was extracted with EtOAc and combined extracts were concentrated under vacuum to give product (86.2g, 95.0%) as pale brown oil. [0312] A mixture of alcohol 18-4 (50.g, 0.18315 mol) and Pd(OH)2 on carbon (20%, 6.26 g, 0.04395 mol) in absolute ethanol (500 ml) was stirred for 7h under the pressure of hydrogen at 50-60 psi. After the reaction, charcoal was removed by filtration and residue was concentrated on rota evaporator to get product 18-5 (15.8 g, 92.7%) as pale brown oil. [0313] To a stirred mixture of amino alcohol 18-5 (15.0 g, 0.16129 mol) and K2CO3 (33.39 g, 0.24195 mol) in aqueous dioxane (~25%, 375 ml dioxane in 125ml water), (Boc)2O (38.66 g, 0.17733 mol) was added drop wise at 0°C. The reaction mixture was stirred overnight at room temperature after the addition. Saturated solution of KHSO4 was added to the above mixture to adjust the pH 3-4 and extracted with EtOAc. The organic phase was concentrated under vacuum to give pure product (27.7 g, 89.0%) as a pale brown oil. 151 WO 2006/002236 PCT/US2005/022062 [0314] To a cooled (-78°C), stirred solution of oxalyl chloride (84 mmol) in CH2C12 (180 ml) was added a solution of DMSO (168 mmol) in CH2C12 (90 ml). After lh, a solution of alcohol 18-6 (56 mmol) in CH2C12 (90 ml) was added. After lh, triethyl amine (281 mmol) was added and stirred for a further hour. Then a solution of saturated aqueous NH4Cl was added and allowed to warm to room temperature. The organics were separated, washed with H2O (x2), saturated brine (x2), then dried, filtered and evaporated under reduced pressure to give the crude aldehyde. Purification by column chromatography affored the pure (S)-aldehyde. [0315] Starting from the other enantiomer, (L)-serine methyl ester leads to the (R) enantiomer. 152 WO 2006/002236 PCT/US2005/022062 [0316] To a stirred solution of Boc-Asp(Obzl)-OH 19-1 (10.0 mmol) in 20 ml of DCM was added 10 ml of trifluoroacetic acid. The mixture was stirred at room temperature for 24h. The reaction progress was followed by LCMS. After completion, the solvent and TFA were removed by evaporation under reduced pressure and lypholization to get white solid as TFA salts. The crude solid was suspended in 50 ml of THF and N-carboethoxy phthalimide (10.5 mmol), Et3N (10 mmol) were added. The mixture was refluxed under N2 for 18hr. Then the reaction was cooled down and the solvents were evaporated off. DCM was added and washed with water, brine, dried over sodium sulfate, filter and concentrated. Purification by chromatography on silica gel column (Hexan/Ethylacetate) to give 2.68 g of colorless oil 19-2, yield 76%. 153 WO 2006/002236 PCT/US2005/022062 [0317] To a stirred solution of (S)-3-((benzyloxy)carbonyl)-2-(l,3-dioxoisoindolin-2-yl)propanoic acid (19-2, 6.07 mmol) in 30 ml of dry THF at-15°C were successively added N-methylmorpholine (6.07 mmol), iso-butylchloroformate (6.07mmol). After stirring for 5 min at-15°C, a solution of NaBH4 (689mg, 18.21 mrnol) in 2.73 ml of water were added at once. The reaction was stirred at -15°C for 2 min, then hydrolyzed with water (30 ml). Extracted with EtOAc (x 3), washed with water (x 3), brine (xl), dried over sodium sulfate, filtered, concentrated. Purification by chromatography on silica gel column (Hexan/Ethylacetate) to give 1.9 g of colorless oil 19-3, yield 92%. [0318] To a stirred solution of (S)-benzyl 4-hydroxy-3-(l,3-dioxoisoindolin-2-yl)butanoate (19-3, 5.6 mmol) in acetonitrile (28 ml) were added perfluoro-1-butane sulfonyl fluoride (44.8 mmol), diisopropylethylamine (44.8 mmol), and diisopropylethylaminie trihydrofiuoride (134 mmol). The mixture was stirred at 50°C overnight. The reaction progress 154 WO 2006/002236 PCT/US2005/022062 was followed by LCMS. After completion, the reaction was cooled down to room temperature, evaporated under reduced pressure. The mixture was then partitioned into DCM, washed with water (x 3), brine (x2), dried over sodium sulfate, filtered, concentrated. Purification by chromatography on silica gel column (Hexan/Ethylacetate) to give light yellow oil 19-4, yield 40%. [0319] To a stirred solution of (S)-benzyl 4-fluoro-3-(l,3-dioxoisoindolin-2-yl)butanoate (19-4,0.5 mmol) in dry ether (5 ml) was added dropwise diisobutylaluminum hydride (1.0 M in toluene, 1.5 mmol) at -78°C. The reaction was stirred at -78°C for approximately 30 min as monitored by LC-MS. After completion, the reaction was quenched by adding water (10 ml) at -78°C. Extracted with ethyl acetate, washed with water (x3), brine (x2), dried over sodium sulfate, filtered and concentrated. The crude product 19-5 was used in the next reaction step. [0320] An alternate route for preparing 19-5 is presented below. 155 WO 2006/002236 PCT/US2005/022062 [0321] (S)-4-fluoro-3-(l,3-dioxoisoindolin-2-yl)butanoic acid 19-4 (0.20 mmol) was dissolved in ethanol (5 ml). This solution was purged with nitrogen for 10 minutes, then 10% palladium on carbon was added (0.02 mmol of palladium) under an atmosphere of nitrogen. Hydrogen was then bubbled rapidly through the solution, while stirring, for approximately lh. The reaction progress was followed with LCMS. The reaction mixture was filtered through celite to remove the palladium. The celite was rinsed twice with methylene chloride. The filtrate was then concentrated to give the crude product. The crude product 19-6 was used for the next reaction step. [0322] 19-6 (0.20 mmol), 1,3 diclyclohexyl carbodiimid (0.30 mmol), ethanethiol (0.6 mmol), and 4-dimethylaminopyridine (0.10 mmol) were dissolved in DMF (5 ml). The mixture was stirred overnight at room temperature. The reaction completion was determined with LCMS.EtOAc was added to the reaction mixture. This was then washed with 156 WO 2006/002236 PCT/US2005/022062 water (2x) and brine (2X). The EtOAc layer was then dried over sodium sulfate, filtered, and concentrated. The crude product was then purified using flash chromatography. [0323] 19-7 (0.20 mmol) was dissolved in dry acetone (10ml). 10% Palladium (0.02mmol) on carbon was then added under an atmosphere of nitrogen. Triethyl silane (0.5mmol) was then added. Bubbling occurred after about 10 seconds, and the reaction was allowed to continue until the bubbling ceased (30 min). The reaction completion was determined using LCMS. The reaction mixture was filtered through a celite plug. The plug was washed twice with methylene chloride, and the filtrate was then concentrated to give the crude product. The crude product was used in the next reaction. [0324] Starting from the other (R) enantiomer, (R)-3-((benzyloxy)carbonyl)-2-(l,3-dioxoisoindolin-2-yl)propanoic acid, leads to the other enantiomer. [0325] The compounds in the table below were prepared using the methodology described in the previous Examples and Methods. The following tables also include compounds described in the experimentals. The starting materials used in the synthesis are recognizable to one of skill in the art and are commercially available or may be prepared using known methods. The compounds were named using ACD/Name Batch Version 5.04 (Advanced Chemistry Development Inc.; Toronto, Ontario; www.acdlabs.cona). 157 158 WO 2006/002236 PCT/US2005/022062 159 WO 2006/002236 PCT/US2005/022062 160 WO 2006/002236 PCT/US2005/022062 161 WO 2006/002236 PCT/US2005/022062 162 WO 2006/002236 PCT/US2005/022062 163 WO 2006/002236 PCT/US2005/022062 164 WO 2006/002236 PCT/US2005/022062 165 WO 2006/002236 PCT/US2005/022062 166 WO 2006/002236 PCT/US2005/022062 167 WO 2006/002236 PCT/US2005/022062 168 WO 2006/002236 PCT/US2005/022062 169 WO 2006/002236 PCT/US2005/022062 170 WO 2006/002236 PCT/US2005/022062 171 WO 2006/002236 PCT/US2005/022062 172 WO 2006/002236 PCT/US2005/022062 173 WO 2006/002236 PCT/US2005/022062 174 WO 2006/002236 PCT/US2005/022062 175 WO 2006/002236 PCT/US2005/022062 176 WO 2006/002236 PCT/US2005/022062 177 WO 2006/002236 PCT/US2005/022062 178 WO 2006/002236 PCT/US2005/022062 179 WO 2006/002236 PCTYUS2005/022062 Table 2 180 WO 2006/002236 PCT/US2005/022062 181 WO 2006/002236 PCT/US2005/022062 182 WO 2006/002236 PCT/US2005/022062 183 WO 2006/002236 PCT/US2005/022062 184 WO 2006/002236 PCT/US2005/022062 185 WO 2006/002236 PCT/US2005/022062 186 WO 2006/002236 PCT/US2005/022062 187 WO 2006/002236 PCT/US2005/022062 188 WO 2006/002236 PCT/US2005/022062 WO 2006/002236 189 PCT/US2005/022062 190 WO 2006/002236 PCT/US2005/022062 191 WO 2006/002236 PCT/US2005/022062 192 WO 2006/002236 PCT/US2005/022062 193 WO 2006/002236 PCT/US2005/022062 194 WO 2006/002236 PCT/US2005/022062 195 WO 2006/002236 PCT/US2005/022062 196 WO 2006/002236 PCT/US2005/022062 197 WO 2006/002236 PCT/US2005/022062 198 WO 2006/002236 PCT/US2005/022062 199 WO 2006/002236 PCT/US2005/022062 200 WO 2006/002236 PCT/US2005/022062 201 WO 2006/002236 PCT/US2005/022062 202 WO 2006/002236 PCT/US2005/022062 203 WO 2006/002236 PCT/US2005/022062 204 WO 2006/002236 PCT/US2005/022062 205 WO 2006/002236 PCT/US2005/022062 206 WO 2006/002236 PCT/US2005/022062 207 WO 2006/002236 PCT/US2005/022062 208 WO 2006/002236 PCT/US2005/022062 209 WO 2006/002236 PCT/US2005/022062 210 WO 2006/002236 PCT/US2005/022062 211 WO 2006/002236 PCT/US2005/022062 212 WO 2006/002236 PCT/US2005/022062 213 WO 2006/002236 PCT/US2005/022062 214 WO 2006/002236 PCT/US2005/022062 215 WO 2006/002236 PCT/US2005/022062 216 WO 2006/002236 PCT/US2005/022062 217 WO 2006/002236 PCT/US2005/022062 218 WO 2006/002236 PCT/US2005/022062 219 WO 2006/002236 PCT/US2005/022062 220 WO 2006/002236 PCT/US2005/022062 WO 2006/002236 221 PCT/US2005/022062 WO 2006/002236 PCT/US2005/022062 222 Table 3 223 WO 2006/002236 PCT/US2005/022062 224 WO 2006/002236 PCT/US2005/022062 225 WO 2006/002236 PCT/US2005/022062 226 WO 2006/002236 PCT/US2005/022062 227 WO 2006/002236 PCT/US2005/022062 228 WO 2006/002236 PCT/US2005/022062 229 WO 2006/002236 PCT/US2005/022062 230 WO 2006/002236 PCT/US2005/022062 231 WO 2006/002236 PCT/US2005/022062 232 WO 2006/002236 PCT/US2005/022062 233 WO 2006/002236 PCT/US2005/022062 234 WO 2006/002236 PCT/US2005/022062 235 WO 2006/002236 PCT/US2005/022062 236 WO 2006/002236 PCT/US2005/022062 237 WO 2006/002236 PCT/US2005/022062 238 WO 2006/002236 PCT/US2005/022062 239 WO 2006/002236 PCT/US2005/022062 240 WO 2006/002236 PCT/US2005/022062 241 WO 2006/002236 PCT/US2005/022062 242 PCT/US2005/022062 WO 2006/002236 243 PCT/US2005/022062 WO 2006/002236 WO 2006/002236 PCT/US2005/022062 Example 20 Assay for Determining KSP Activity [0326] This example provides a representative in vitro assay for determining KSP activity in vitro. Purified microtubules obtained from bovine brain were purchased from Cytoskeleton Inc. (Denver, Colorado, USA). The motor domain of human KSP (Eg 5, KNSL1) was cloned, expressed, and purified to greater than 95% homogeneity. Biomol Green was purchased from Affinity Research Products Ltd. (Matford Court, Exeter, Devon, United Kingdom). Microtubules and KSP motor protein (/. e., the KSP motor domain) were diluted in assay buffer (20 mM Tris-HCl (pH 7.5), 1 mM MgCl2,10 mM DTT and 0.25 mg/ml BSA) to a final concentration of 35 ug/ml microtubules and 45 nM KSP. The microtubule/KSP mixture was then pre-incubated at 37°C for 10 min to promote the binding of KSP to microtubules. [0327] To each well of the testing plate (384-well plate) containing 1.25 µl of inhibitor or test compound in DMSO (or DMSO only in the case of controls) were added 25 µl of 244 WO 2006/002236 PCT/US2005/022062 ATP solution (ATP diluted to a concentration of 300 µM in assay buffer) and 25 µl of the above-described microtubule/KSP solution. The plates were incubated at room temperature for 1 hour. Following incubation, 65 µl of Biomol Green (a malachite green-based dye that detects the release of inorganic phosphate) was added to each well. The plates were incubated for an additional 5-10 minutes then the absorbance at 630 nm was determined using a Victor II plate reader. The amount of absorbance at 630 nm corresponded to the amount of KSP activity in the samples. The IC50 of each inhibitor or test compound was then determined based on the decrease in absorbance at 630 nm at each concentration, via nonlinear regression using either XLFit for Excel or Prism data analysis software by GraphPad Software Inc. Example 21 Inhibition of Cellular Proliferation in Tumor Cell Lines Treated with KSP Inhibitors [0328] Cells were plated in 96~well plates at densities from 500 cells/well of a 96-well plate and allowed to adhere/grow for 24 hours. They were then treated with various concentrations of drug for 72 hours. Than 100 µl of CellTiter Glo is added, atetrazolium-based assay using the reagent 3-(4,5-dimethylthiazol-2-yl) 5- (3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) (U.S. Patent No. 5,185,450) (see Promega product catalog #G3580, CellTiter 96 Aqueous One Solution Cell Proliferation Assay), and incubated in the dark for 30 minutes. The amount of luminescence was determined for each well using a Walloc Trilux plate reader, which correlates with the number of cells/well. The number of viable cells in the wells, that received only DMSO (0.5%) serve as the 0% inhibition data point, while wells without cells serve as 100% inhibition of cell growth. The drug concentration that resulted in a 50% growth inhibition (GI50) was determined graphically from sigmoidal dose-response curves 245 WO 2006/002236 PCT/US2005/022062 of log-transformed dose values versus cell counts (percent of control) at 72 hours of continuous drug exposure. [0329] The cell lines used are listed below. [0330] The cell proliferation assay was performed as described above. Cancer Cell Lines Colo 205 - colon carcinoma RPMI1640 +10%FBS +1% L-glutamine +1% P/S +l%NaPyr.+ Hepes +4.5g/L Glucose +l%NaBicarb. MDA 435- breast cancer- high met EMEM + 10% FBS + 1%P/S + 1%L-Glutamme+1%NEAA +l%NaPyr+ l%vitamins HCT-15 and HCT116 -colon carcinoma RPM 1640 +10%FBS +1% L-glutamine +1% P/S Drug Resistant Cell Lines KB3.1- colon epidermal carcinoma; parental cell line Iscove's +10%FBS +1% L-glutamine +1% P/S KBV1 - p-glycoprotein associated multi-drug resistant cell line RPM 1640 +10%FBS +1% L-glutamine +1% P/S +0.2µg/ml Vinblastine KB85 - p-glycoprotein associated multi-drug resistant cell line DMEM +10%FBS +1% L-glutamine +1% P/S + l0ng/ml Colchicine Example 22 Clonogenic Softagar Assay Protocol: [0331] Human cancer cells were plated at a density of 3xl05 cells / well in a 6-well plate. The next day compound of interest at a certain concentration is added to each well. After 24 and 48 hrs incubation in the presence of compound of interest the cells were harvested, washed and counted. The following steps were performed using the Multimek 96 robot. Than 246 WO 2006/002236 PCT/US2005/022062 500 viable cells / well were plated in a 96-well plate that was coated with PolyHema previously to prevent attachment of the cells to the bottom of the well. Agarose (3% stock) was melted, diluted in warmed media and added to the cells to a final concentration of 0.5%. After the soft agar solidified the plates were incubated at 37°C for 6 days. Alamar blue dye was added to cells and plates were incubated for additional 6 hrs. The OD change was measured on a Tecan plate reader and is considered to correlate with the number of colonies formed in soft agar. [0332] Preferred compounds of the invention have a biological activity as measured by an IC50 of less than about 1 mM in assay protocols described in Examples 20-22, with preferred embodiments having biological activity of less than about 25µuM, with particularly preferred embodiments having biological activity of less than about 1000 nM, and with the most preferred embodiments having biological activity of less than about 100 nM. Example 23 Cell Lines [0333] The HCT-116 human colon carcinoma cell lines were obtained from the American Type Culture Collection (ATCC; Rockville, MD). [0334] Cells were cultured using standard technique in RPMI1640 supplemented with 10% fetal bovine serum, 2 mM glutamine, 1 mM sodium pyruvate (Life Technologies Inc., Gaithersburgs MD) and maintained routinely in a humidified chamber at 37°C and 5% carbon dioxide. 247 WO 2006/002236 PCT/US2005/022062 Example 24 In Vivo Implantation of Cell Lines and Efficacy Studies [0335] Cells to be implanted in mice were harvested from cell culture flasks during exponential growth, washed once with sterile phosphate-buffered saline (PBS), counted, and resuspended in Hank's Balanced Salt Solution to a suitable concentration prior to implantation. [0336] All animal studies were in accordance with the Institute of Laboratory Animal Research (National Institutes of Health, Bethesda, MD) Guide for the Care and Use of Laboratory Animals. Nine to twelve week old female athymic nu/nu mice purchased from Charles River Laboratories (Wilmington, MA) were used. [0337] Mice received subcutaneous injections into the hind flank on Day 0 with 5 X 106 HCT-116 cells. For multi-dose efficacy studies, animals with established tumors (approximately 300 mm3) were randomized into treatment groups of approximately 10 mice each for efficacy studies. Compounds of interest or their vehicles were administered orally to mice, with the compounds prepared in a vehicle containing 10% Captisol® to appropriate concentrations. Tumor growth was measured twice weekly using Vernier calipers for the duration of the treatment. Tumor volumes were calculated as the product of (length x width2)/2. For stastical analysis, p-values were calculated using the two-tailed Student's t test. 248 WO 2006/002236 PCT/US2005/022062 Example 25 In Vivo Mechanistic Studies in HCT-116 Colon Carcinoma Tumors [0338] To evaluate early pharmacodynamic changes to tumors after treatment with a KSP inhibitor, mice bearing tumors ranging from 300-600 mm3 in volume were treated with a single oral dose of compounds of interest at various concentrations. Control animals received an oral dose of vehicle. At predetermined timepoints, individual mice were euthanized, with plasma and half of the resected tumors collected for PK and half of the tumors fixed in 10% buffered formalin, followed by transference to 70% ethanol by 24 hrs of fixation. Example 26 Phospho-Histone H3, Cleaved PARP and Cleaved Caspase 3 Immunohistochemistry. [0339] Sections were prepared from formalin-fixed, paraffin-embedded subcutaneous tumors. For detection of phospho-histone H3, a rabbit polyclonal anti-human antibody (Cat. #9701L, Cell Signaling, Beverley MA) was used. A biotinylated anti-rabbit secondary antibody (Jackson Labs, West Grove, PA) was also employed in this detection assay. Slides were stained using an automated slide stainer and compatible ancillary reagents (Ventana Medical Systems, Tucson AZ). Cell conditioning for phosho-histone H3 was CC2 mild. For detection of cleaved PARP, a rabbit polyclonal antibody (Cat # 44-698G, BioSource, Camarillo CA) and a biotinylated anti-rabbit secondary antibody (Jackson Labs, West Grove, PA) followed by a peroxidase-based irnmunostaining protocol (Vectastain® ABC Elite KIT, Vector Laboratories, Burlingame, CA) were used. Heat induced epitope retrieval was accomplished using citrate buffer (Decloaker, BioCare, Walnut Creek, CA) before staining on an automated stainer (Dako, Carpenteria, CA). For detection of cleaved Caspase 3, a rabbit polyclonal 249 WO 2006/002236 PCT/US2005/022062 antibody (Cat. # 44-698G, BioSource, Camarillo CA) and a biotinylated anti-rabbit secondary antibody (Jackson Labs, West Grove, PA) followed by a peroxidase-based immunostaining protocol (Vectastain® ABC Elite KIT, Vector Laboratories, Burlingame, CA) were used. Heat induced epitope retrieval was accomplished using citrate buffer (Decloaker, BioCare, Walnut Creek, CA) before staining on an automated stainer (Dako, Carpenteria, CA). In all cases the chromagen used for these assays was DAB. Example 27 KSP Immunohistochemistry [0340] Sections were prepared from formalin-fixed, paraffin-embedded subcutaneous tumors. For detection of KSP, a rabbit polyclonal anti-human antibody (Cat. # AKIN03 from Cytoskeleton) was used. A biotinylated anti-rabbit secondary antibody (Jackson Labs, West Grove, PA) was also employed in this detection assay. Slides were stained using an automated slide stainer and compatible ancillary reagents (Ventana Medical Systems, Tucson AZ). Cell conditioning for KSP was a CC1 standard. The chromagen used for this assay was DAB. 250 WO 2006/002236 PCT/US2005/022062 WHAT IS CLAIMED IS: 1. A compound of formula I: wherein: R1 is selected from the group consisting of aminoacyl, acylamino, carboxyl, carboxyl ester, aryl, and alkyl optionally substituted with hydroxy or halo; R2 is selected ftom the group consisting of hydrogen, alkyl, and aryl; R3 is selected from the group consisting of hydrogen and -X-A, wherein X is selected from the group consisting of-C(O)-, -C(S)-, -S(O)-5 -S(O)2-, and -S(O)2-N(R)-, where R is hydrogen or alkyl; and A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; or R1 and R3, together with the carbon atom attached to R1 and the nitrogen atom attached to R3 form a heterocyclic or substituted heterocyclic group; 251 WO 2006/002236 PCT/US2005/022062 R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl, and -[alkylene]p-NR10R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and Ru jare independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl, or when R10 is hydrogen, Ru is hydroxy, alkoxy or substituted alkoxy; or when R1 and R3, together with the carbon and nitrogen atoms bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then R3 and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; Rs is selected from the group consisting of L-A1, wherein L is selected from the group consisting of -S(O)q- where q is one or two, and C1 to C5 alkylene optionally substituted with hydroxy, halo, or acylamino; and A1 is selected from the group consisting of aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl, and substituted cycloalkyl; and one of either R6 or R7 is selected from the group consisting of heterocyclic, aryl and heteroaryl, all of which may be optionally substituted with -(R8)m where R8 is as defined herein and m is an integer from 1 to 3, and the other of R6 or R7 is selected from the group consisting of hydrogen, halo, and alkyl; or R6 and R7 are both hydrogen; , R8 is selected from the group consisting of cyano, alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; or pharmaceutically acceptable salts, esters or prodrugs thereof. 252 WO 2006/002236 PCT/US2005/022062 2. The compound of claim 1, wherein the compound is represented by formula II: II wherein: Ar is selected from the group consisting of phenyl, pyridinyl, pyrazinyl, and thiazolyl; X1 is selected from the group consisting of-C(O)- and -S(O)2-; A2 is selected from the group consisting of aryl, heteroaryl, beterocyclic, and cycloalkyl, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, halo, hydroxy, and nitro; A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyl ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; 253 WO 2006/002236 PCT/US2005/022062 R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing heterocyclic, -[alkylene]p-nitrogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl, and -[alkyIene]p-NR10R11 wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl or when R10 is hydrogen, R11 is hydroxy, alkoxy or substituted alkoxy; or when R13 and A, together with the carbon atom and the X1 group bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then X1-A and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R8 is selected from the group consisting of cyano, alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; R12 is hydrogen, alkyl; R13 is alkyl or aryl; R13 and X1-A, together with the carbon atom attached to R13 and the nitrogen atom attached to X1 join to form a heterocyclic or a substituted heterocyclic group; R14 is hydrogen or C1 to C4 alkyl; m1 is an integer equal to 0 to 2; n is an integer equal to 1 to 3; or pharmaceutically acceptable salts, esters or prodrugs thereof. 3. The compound of claim 1, wherein the compound is represented by formula III: 254 WO 2006/002236 PCT/US2005/022062 wherein: X1 is-C(O)-or-S(O)2-; A2 is selected from the group consisting of aryl, heteroaryl, heterocyclic, and cycloalkyi, all of which may be optionally substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, halo, hydroxy, and nitro; A is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, carboxyl, carboxyi ester, aminoacyl, optionally substituted heteroaryl, optionally substituted heterocyclic, and optionally substituted cycloalkyl, wherein the optionally substituted groups are substituted with 1 to 4 substituents selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, aryloxy, substituted aryloxy, cyano, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, acyl, carboxyl, carboxyl ester, oxo (except when A is optionally substituted aryl or optionally substituted heteroaryl), halo, hydroxy, -S(O)2-R9 where R9 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl, and nitro; R8 is selected from the group consisting of alkyl, alkenyl, alkynyl, -CF3, alkoxy, halo, and hydroxy; R4 is selected from the group consisting of hydrogen, linear alkyl, -alkylene-aminoacyl, -alkylene-oxyacyl, -alkylene-acyloxy, -alkylene-hydroxy, -[alkylene]p-nitrogen-containing 255 WO 2006/002236 PCT/US2005/022062 heterocyclic, -[alkylene]p-nitxogen-containing substituted heterocyclic, -[alkylene]p-nitrogen-containing heteroaryl, -[alkylene]p-nitrogen-containing substituted heteroaryl, and -[alkylene]p-NR10Ru wherein p is an integer from 0 to 1, alkylene is a straight chained alkylene optionally mono- or disubstituted with one of the foregoing substituents selected from the group consisting of amino, substituted amino, hydroxy, alkyl, substituted alkyl, carboxyl, carboxyl ester, oxo, spirocycloalkyl, and halo; R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, -S(O)-alkyl, -S(O)-substituted alkyl, -S(O)2-alkyl, -S(O)2-substituted alkyl, heterocyclic, substituted heterocyclic, acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, and substituted cycloalkyl or when R10 is hydrogen, R11 is hydroxy, alkoxy or substituted alkoxy; or when R15 and A, together with the carbon atoms and X1 bound respectively thereto, do not form a heterocyclic or substituted heterocyclic group, then X1, A and R4, together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group; R15 is selected from the group consisting of ethyl, isopropyl, t-butyl, or phenyl; R15 and X1-A, together with the carbon atom attached to R15 and the nitrogen atom attached to X' join to form a heterocyclic or a substituted heterocyclic group; R16 is hydrogen or methyl; R17 is hydrogen or methyl; m1 is an integer equal to 0,1 or 2; or pharmaceutically acceptable salts, esters or prodrugs thereof. 4. The compound of claim 1, wherein the compound is represented by formula IV: 256 WO 2006/002236 PCT/US2005/022062 IV wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. 5. The compound of claim 1, wherein the compound is represented by formula V: wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. 6. The compound of claim 1, wherein the compound is represented by formula VI: 257 WO 2006/002236 PCT/US2005/022062 wherein X1, A, A2, R4, R8, R15, R16, R17, and m1 are as defined above. 7. The compound of claim 1, wherein R1 is selected from the group consisting of phenyl, methyl, iyo-propyl, t-butyl, l-methyl-n-prop-l-yl, and 2-hydroxy-iso-propyl. 8. The compound of claim 1, wherein R2 is selected from the group consisting of hydrogen, methyl, and ethyl. 9. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and A is unsubstituted and selected from the group consisting of l,3-benzothiadiazol-4-yl, t-butoxy, butoxy, n-butoxy, carboxyl, cyclohexyl, 2,2-dimethylpropoxy, ethoxy, furan-3-yl, hydrogen, isoxazol-3-yl, methoxy, methyl, 2-methylpropoxy, phenyl, piperidin-3-yl, piperidin-4-yl, n-propoxy, pyrizin- 2-yl, pyrazin-2-yl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydro-2H-pyran-4-yl, 1H- tetrazol-1-yl, 2H-tetrazol-2-yl, thiazol-4-yl, l,3,4-thiadiazol-2-yl, l,3-benzothiadiazol-6-yl, 3,3- dihydrobenzo[l,2,3]thiadiazol-4-yl, benzimidazol-2-yl, benzimidazol-6-yl, benzo[l,2,5]thiadiazole, benzoxadiazol-4-yl, cyclopentyl, imidazol-4-yl, indazol-6-y, isooxazol- 5-yl, morpholin-2-yl morpholino, oxazol-4-yl, piperidin-N-yl, pyrazol-3-yl, pyrrolidin-2-yl pyrrolidin-3-yl, pyrrolidin-N-yl, tetrazol-5-yl, and thiadiazol-4-yl. 10. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and A is a substituted aryl or heteroaryl group selected from the group consisting of 5-methyl-2H-imidazol-4yl, 2- 258 WO 2006/002236 PCT/US2005/022062 aminothiazol-4-yl, 4-f-butylphenyl, 2-chlorophenyl, 2-chloro-6-methylpyrid-4-yl, 3-chlorophenyl, 4-chlorophenyl, 6-chloropyridin-3-yl, 3,4-dichlorophenyl, 2,4-difiuorophenyl, 1,5-dimethyI-lH-pyrazol-3-yl, 2,4-dimethylthiazol-5-yl, l-ethyl-3-methyl-lH-pyrazol-5-yl, 2-methoxyphenyl, 4-methoxyphenyl, 4-methylisoxazol-3-yl, 5-methylisoxazol-4-yl, 4-methylphenyl, 1 -methyl-3-trifluoromethyl-1 H-pyrazol-4-yl, 1 -methyl-5-chloro-1 H-pyrazol-4-yl, 5-methyl-lH-pyrazol-3-yl, 6-methylpyridin-3-yl, 2-pyrrolidin-3-ylphenyl, 4-(trifluoromethyl)phenyl, 6-(trifluoromethyl)pyridin-3-yl, 2,5-dimethyloxazol-4-yl, 2-aminothiazol-4-yl, 4-methylpyrazol-5-yl, 3-trifluoromethylpyrazol-4-yl, 2-methyl-3-trifluoromethylpyrazol-5-yl, 4-chloro-l,3-dimethylpyrazolo[3,4]pyridine, and 1-methylbenziinidazol-2-yl. 11, The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and A is a substituted heterocyclic or cycloalkyl selected from the group consisting of 3- [(aminoacetyl)amino]cyclohexyl, 3-(2-aminoethyIsulfonylamino)cyclohexyl, 1 -methylpiperazin-4-yl, l-methyicarbonylpiperidin-4-yl, l-methoxycarbonylpiperidin-4-yl, quinuclidin-3-yl, 2-oxopyrrolidin-5-yl, 2-oxopyrrolidin-4-yl, 2-oxo-dihydrofuran-5-yl, 2-oxothiazolidin-4-yl) and 3-hydroxypyrrolidin-5-yl. 12. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and A is a substituted alkyl selected from the group consisting of 3-amino-2-oxo-l(2H)-pyridinylmethyl, cyanomethyl, (N,N-dimethylamino)methyl, ethoxymethyl,p-fluorophenoxymethyl, hydroxymethyl, 1H- imidazol-1-ylmethyl, methoxymethyl, (N-methylamino)methyl, methylsulfonylmethyl, (5- methyl-lH-tetrazol-l-yl)methyi, (5-methyl-2H-tetrazol-2-yl)methyl, morpholin-4-ylmethyl, 1H- pyrazol-1-ylmethyl, lH-l,2,3-triazol-l-yhnethyl, 2H-l,2,3-triazol-2-yhnethyl, lH-l,2,4-triazol- 1-ylmethyl, 2H-l,2,4-triazol-2-yhnethyl, 4H-ls2,4-triazol-4-yhnethyl5 IH-tetrazol-l-yhnethyl, lH-tetrazol-5-ylmethyl, 2H-tetrazol-2-ylmethyl. imidazol-4-ylmethyl, l-methylpyrazol-3- ylmethyl, piperidin-4-ylmethyl, trifluoromethyl, dimethylaminoethyl, and 2-oxo-3- aminopyrrolidin-1 -ylmethyl. 259 WO 2006/002236 PCT/US2005/022062 13. The compound of claim 1, wherein X or X1 is C(O) or S(O)2 and R1 and R3 are cyciized to form a divalent heterocyclic group such as 2-oxopiperidin-N-6-yl or pyrrolidin-1 -yl. 14. The compound of claim 1, wherein A is N-methylaminocarbonyl. 15. The compound of claim 1, wherein R4 is selected from the group consisting of: hydrogen, piperidin-4-yl, -(CH2)2-NH2, -CH2-azetidin-3-yl, -CH2-(2,5-dihydropyrrol-3-yl), -(CH2)3- imidazol-1-yl, -CH2-(lH-imidazol-4-yl), -CH2-pyridin-3-yl, -CH2-(2-hydroxypyridin-4-yl), -CH2-(6-hydroxypyridin-3-yl), -CH2-morpholin-2-yl, -CH2-pyrrolidin-3-yl, -CH2-(3- fluoropyrrolidin-3-yl), -CH2-(3-hydroxypyrrolidin-3-yl), -CH2-(4-fluoropyrrolidin-3-yl), -CH2- (4-hydroxypyrrolidin-3-yl), -CH2-(2-hydroxymethylpyrrolidin-3-yl), -CH2-piperidin-3-yl, -CH2- [lH-(l,2,3-triazol-4-yl)], -CH2CH(NH2)CH2OH, -(CH2)3-OH, -(CH2)3-O(CO)-phenyl, -(CH2)3- NH2, -(CH2)3-NHCH3, -(CH2)3-N(CH3)2, -(CH2)3-NHOCH3, -(CH2)3-NHSO2CH3, (CH2)3NH- (5-cyanopyridin-2-yl), -(CH2)3NH-cyclopropyl, -(CH2)3NH-cyclobutyl, -(CH2)3-(lH-imidazol-2- yl), -(CH2)3-(2-hydroxyethylpiperidin-l-yl), -(CH2)3NH(2-hydroxymethylphenyl), -(CH2)3NH- (5-1rifluorome%lpyridm-2-yl),-(CH2)3NHCH2-cyclopropyl,(CH2)3NHCH2-{5-(pyridin-3- yloxy)-lH-indazol-3-yl},-(CH2)3NHCH2-(5-methoxy-lH-indazol-3-yl),-(CH2)3NHCH2-(6- fiuoro-lH-indazol-3-yl), -CH2CHOHCH2NH2, -CH2CH(CH2OH)CH2NH2, -CH2C(CH3)2CH2- NCCHsk, -CH2C(CH3)2CH2-(4-methylpiperazin-l-yl), -(CH2)2C(O)NH2, -(CH2)2CH(NH2)C(O)NH2, -(CH2)2CH(NH2)C(O)OH, -(CH2)3CH(NH2)CH2C(O)NH2, -(CH2)2CH(NH2)CH2OH, -(CH2)2CH(NH2)CH3, -(CH2)3NHC(O)CH2NH2, -(CH2)3NHC(O)CH(NH2)CH(CH3)2, -CH2CHFCH2NH2, -(CH2)2NHC(O)CH2NH2, -(CH2)3- NHCH2CH2OH, -(CH2)3-NHCH2CO2H, -(CH2)3-NHCH2CO2CH2CH3, -(CH2)3-N(CH2CH2OH)2, -(CH2)3-NHCH(CH2OH)2, -(CH2)3CH3, -(CH2)2CH(NH2)CH2OH, -(CH2)2C(CH3)2NH2, -(CH2)2CH(NH2)CH2OCH3, -(CH2)2CH(NH2)CH2F, -CH2CHFCH(NH2)CH2OH, and -(CH2)2spirocylcopropyl-NH2. 16. The compound of claim 1, wherein L is methylene and A1 is selected from the group consisting of phenyl, 6-aminopyridin-2-yl, 3-chlorophenyl, 3-cyanophenyl, 2,4-difluorophenyl, 260 WO 2006/002236 PCT/US2005/022062 2,5-difluorophenyI, 3,5-difluorophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-hydroxyphenyl, 3-methoxyphenyl, l-(5-methyl)-isoxazol-3-yl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, tetrahydropyran-4-yl, thiazol-4-yl, and 5-trifluoromethylfuran-2-yl. 17. The compound of claim 1, wherein R7 is hydrogen, halo, or methyl. 18. The compound of claim 17, wherein R6 is selected from the group consisting of phenyl, 3-bromophenyl, 3-chlorophenyl, 4-cyanophenyl, 2,5-difluorophenyl, 3-fluorophenyl, 2- methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-methylphenyl, pyrazin-2-yl, pyridin-2- yl, thiazol-2-yl, 2-trifluoromethylphenyl, and 3-trifluoromethylphenyl. 19. The compound of claim 1, wherein R6 is hydrogen, halo, or methyl. 20. The compound of claim 19, wherein R7 is a group such as 3-fiuorophenyl. 21. The compound of claim 1, wherein R3 and R4 cyclize to form 1 -oxa-3,7- diazaspiro[4.4]nonan-2-one or 6-oxa-2,9-diazaspiro[4.5]decan-8-one. 22. A compound selected from the group consisting of: N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl] -4-methylbenzamide; N-(3 -aminopropyl)-N-[( 1R)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2-methylpropyl]benzamide; N-(3-aminopropyl)-N-[(R)-(l-benzyl-4-phenyl-lH-imidazol-2-yl)(phenyl)methyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(R)-(l-benzyl-4-phenyl-lH-imidazol-2-yl)(phenyl)methyl]benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-(trifluoromethyl)benzamide; 261 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2,4-difluorobenzaffiide; N-(3-aminopropyl)-4-methyl-N- {2-methyl-1 -[ 1 -(3 -methylbenzyl)-4-phenyl-1H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl} benzamide; N-(3-aininopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-(triiWromethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-methoxyphenyl)-lH-imidazol-2-yl]-2-methylpropyl} -2,4-difluoroben2amide; N-(3 -aminopropyl)-N- {(1R)-1-[1 -benzyl-4-(3 -chlorophenyl)-1 H-imidazol-2-yl]-2-methylpropyl}ben2amide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopiopyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-iftethylpropyl}-4-(trifluoromeihyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imida2X)l-2-yl]-2-methylpropyl}~2,4-difluorobenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(4-methylphenyl)-lH-imidazol-2-yl]-2-methylpropyl} benzamide; N-(3-aminopropyl)-N- {(1R)-1 -[1 -ben2yl-4-(4-metbylphenyl)-1 H-imidazol-2-yl]-2-meiliylpropyl} -4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(4-methylphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(4-methylphenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2J4-difluorobenzamide; N N-(3-aminopropyl)-N-[(l R)-l -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-{(lR)~ 1 -[1 -(3,5-difluorobenzyl)-4-phenyHH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3,5-difluoroben2yl)-4-phenyl-lH-imidazol-2-yl3-2-metfaylpropyl}benzamide; 262 WO 2006/002236 PCT/US2005/022062 N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methyl-N- { 3-[(methylsulfonyl)amino]propyl} benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-metiiylpropyl]-N-[(3R)-piperidin-3-ylmethyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-[(3S)-piperidin-3 -ylmethyl]benzamide; N-(3-aminopropyl)-4-methyl-N-{(lR)-2-methyl-l-[l-(4-methylbenzyl)-4-phenyl-1 H-imidazol-2-yl]propyl} benzamide; N-(3-aminopropyl)-N-{(lR)-2-methyl-l-[l-(4-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-4-methyl-N-{(lR)-2-methyl-l-[l-(2-methylbenzyl)-4-phenyl-1 H-imidazol-2-yl]propyl }benzamide; N-(3-aminopropyl)-N-{(lR)-2-methyl-l-[l-(2-methylben2yl)-4-phenyl-lH-injidazol-2-yl]propyl}benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-[2,2-dimethyl-3 -(4-methylpiperaziii-1 -yl)propyl jbenzaraide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-[2,2-dimethyl-3-(4-methylpiperazin-l-yl)propyl]-4-niethylbenzamide; N-[(lR)-1-(1-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methyl-N-[(3R)-piperidin-3-ylmethyl]benzamide; N-[(lR)-l-(l-benzyl-phenyl-lH-imidazol-2-yl)-2-meihylpropyl]-4-methyl-N-[(3S)-piperidin-3-ylmethyl]benzamide; N-(3-aminopropyl)-N-((lR)-l-{l-benzyl-4-[2-(trifluoromethyl)phenyl]-lH-imidazol-2-yl}-2-methylpropyl)benzamide; N-(3-aminopropyl)-N-((lR)-l-{l-benzyl-4-[2-(trifluoromethyl)phenyl]-lH-imidazol-2-yl}-2-methylpropyl)-4-methylbenzamide; N-(3-aminopropyl)-N-((lR)-l-{l-benzyl-4-[2-(trifluoromethyI)phenyl]-lH-imidazol-2-yl}-2-methylpropyl)-2,4-difluorobenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyI}-4-methoxybenzamide; N-(3 -aminopropyl)-N- { (1R)-1 -[ 1 -benzyl-4-(3-chlorophenyl)-1 H-imidazol-2-yl]-2-methylpropyl} -3 -chlorobenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -4-chlorobenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazx)l-2-yl]-2-methylpropyl} -4-tert-butylbenzamide; 263 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yI]-2-methylpropyl}-3,4-diclilorobenzainide; N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-N-{3-[(5-cyanopyridin-2-yl)airdno]propyl}benzamide; N-{(lR)-l-[l-benzyl-4-(3-bromophenyl)-lH-imidazoI-2-yl]-2-methylpropyl}-N-(3-{[5-(trifluoromethyl)pyridin-2-yl]amino}propyl)benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-piperidin-4-ylbenzamide; N-[(lR)-l-(l-benzyI-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methyl-N-piperidin-4-ylbenzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-2,4-difluoro-N-piperidin-4-ylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}cyclohexanecarboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -6-cMoronicotinamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imida2X)l-2-yl]-2,2-dimethylpropyl}-4-methylbenzamide; N-(3-aininopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(2,4-difluoroben2yl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(2,4-difluorobenzyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-4-methylben2amide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-N-[3-(dimethylamino)-2,2-dimethylpropyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyI-lH-imidazol-2-yl)-2-methylpropyl]-N-[3-(dimethylamino)-252-dimethylpropyl]-4-methylben2amide; N-(3-aminopropyl)-N- {(1R)-1 -[1 -benzyl-4-(3-chlorophenyl)-1 H-imidazol-2-yl]-2,2-dimethylpropyl}-6-chioronicotinamide; N-(3-aminopropyl)-6-chloro-N-{(lR)-l-[4-(3-chlorophenyl)-l-(3,5-difluorobenzyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}nicotinamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-5-methyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyljbenzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-5-methyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methylbenzatnide; 264 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-5-methyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-2,4-difluorobenzamide; N-(3-ainiiiopropyl)-N-[(lR)-l-(l-ben2yl-5-methyl-4-phenyl-lH-iniidazol-2-yl)-2-methylpropyl]-6-chloronicotinamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-chlorobenzamide; N-(3-atninopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chIorophenyl)-lH-imidazol-2-yl]-2-mettiylpropyl}-2-chloro-6-methylisonicotinamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imida2X)l-2-yI]-2-methylpropyl}-3-ftiraniide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-5-metb.yl-2H-imidazole-4-carboxamide; N-(3-aminopropyl)-N- {(1R)-1 -[1 -benzyl-4-(3-chlorophenyl)- lH-imidazol-2-yl]-2-methylpropyl} -2-methoxybenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}pyridine-2-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazoI-2-yl]-2-methylpropyl} -1,5 -dimethyl-1 H-pyrazole-3 -carboxamide; N-(3-aminopropyl)-N-[(l R)-1 -(1 -benzyl-4-phenyl-lH-imidazol-2-yl)-l ,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-ph6nyl-lH-imidazol-2-yl)-l,2-dimethylpropyl]-4-methylbenzamide; N-(2-aminoethyl)-N-[(l R)-1-(1-benzyl-4-phenyl- lH-imidazol-2-yl)-2-methylpropyl]-4-methylbenzamide; N-(2-aminoethyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]benzamide; N-(3-aininopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-cbJorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-l,3-thiazole-4-carboxamide; N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3-ylinethyl)benzamide; N-{(lR)-l-[4-(3-chlorophenyl)-l-(3,5-difluorobenzyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3-ylmethyl)benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyI-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}ben2:enesulfonaniide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylisoxazole-3-carboxamide; 265 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-metiiylpropyl}isoxazole-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-iniidazol-2-yl]-2-methylpropyl}-5-methyl-lH-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -2,4-dimethyl-1,3 -thiazole~5-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-metb.ylpropyl}tetrahydrofuran-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}piperidine-4-carboxamide; 2-amino-N-(3 -aminopropyl)-N- {(1R)-1-[1 -benzyl-4-(3 -chlorophenyl)-1H-imidazol-2-yl]-2-methylpropyl} -1,3 -thiazole-4-carboxamide; N-[(lR)-l-(l-ben2yl-4.phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-(lH-imidazol-4-ylmethyl)benzamide; N N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(6-hydroxypyridin-3-yl)methyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2^-dimethylpropyl]-N-(pyridin-3-ylmethyl)benzamide; N-[(lR)4 N-[(lR.)-l-(l-benzyl-4-phenyHH-imida2ol-2-yl)-2,2-dimethylpropyl]-N-(pyrrolidin-3-ylmethyl)benzamide; N-[(1R)-aminopropyl)-N-[(lR)-l-Cl-benzyM-phenyl-lH-imidazol^-yl)^^-dimethylpropyl]-6-methylnicotuiamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[(cyclopropylmethyl)amino]propyl}benzainide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-({[5-(pyridin-3-yloxy)-lH-uidaJrol-3-yl]methyl}amino)propyI]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(5-methoxy-lH-indazol-3-yl)methyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyHH-imidazol-2-yL)-2,2-dimethylpropyl]-N-(3-{[(6-fluoro-lH-indazol-3-yl)methyl]amino}propyl)benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[5-(pyridin-3-yloxy)-lH-indazol-3-yl]methyl}benzamide; 266 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-hydroxypropyl)benzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l,5-dimethyl-lH-pyrazoIe-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3R)-3,5-diamino-5-oxopentyl]benzamide; N-{3-[(aminoacetyl)amino]propyl}-N-[(lR)-l-(l-benzyl-4-phenyl-lH-unidazol-2-yl)-2s2-dimethylpropyl]benzamide; N-{2-[(aminoacetyl)amino]ethyl}-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N4(lR)-l(l-benzyl-4-phenyl-lH-iinidazol-2-yl)-2-meth.ylpropyl]-l,5-dimethyl-N-(piperidin-3-ylmethyl)-lH-pyrazole-3-carboxamide; (2R)-N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}tetrahydrofuran-2-carboxamide; (2S)-N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}tetrahydrofuran-2-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}pyra2ine-2-carboxamide; 3-{benzoyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2^-dimethylpropyl]amino}propyl benzoate; N-{(lR)-l-[4-(3-chlorophenyl)-l-(3,5-difluorobenzyl)-lH-imidazol-2-yl]-2,2-dimethylpropyl}-l,5-dimethyl-N-[(3R)-pyrrolidin-3-ylmethyl]-lH-pyrazole-3-carboxamide; N-{(lR)-l-[4-(3-chlorophenyl)-l-(3,5-difluorobenzyl)-lH-imidazol-2-yI]-2,2-dimethylpropyl} -1,5-dimetiiyl-N-[(3 S)-pyrrolidin-3 -ylmethyl]-1 H-pyrazole-3 -carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-l-methyl-3-(trifluoromethyl)-lH-pyrazole-4-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-5-chloro-l-methyl-lH-pyrazole-4-carboxamide; N-(3-aminopropyl)-N>{(lR)-l-[l-benzyl-4-(3-cMorophenyl)-lH-iniidazol-2-yl]-2-methylpropyl}-2-(dimethylamino)acetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(lH-imidazol-2-yl)propyl]ben2amide; 1 -benzyl-6-(l -benzyl-4-phenyl-1 H-imidazol-2-yl)piperidin-2-one; l-benzyl-6-[l-(3-chloroben2yl)-4-phenyl-lH-imidazol-2-yl]piperidin-2-one; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-l,5-dimethyl-lH-pyrazole-3-carboxamide; 267 WO 2006/002236 PCTAJS2005/022062 N-[(l R)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpr opyl]-N-{3-[(2-hydroxyethyl)amino]propyl}benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(cyclopropylamino)propyl]benzamide; N-(3-aminopropyl)-N-{(lR)-2-methyl-l-[4-phenyl-l-(l,3-thiazol-4-ylmethyl)-1 H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-4-methyl-N-{(lR)-2-methyl-l-[4-phenyl-l-(l,3-tbiazol-4-ylmethyl)-lH-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-2,4-difiuoro-N-{(lR)-2-methyl-1 -[4-phenyl-1 -(1,3-thiazol-4-ylmethyl)-lH-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-6-chloro-N-{(lR)-2-methyl-l-[4-phenyl-l-(l,3-thiazol-4-ylmethyl)-lH-imidazol-2-yl]propyl}nicotinamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-pyridin-2-yl-lH-imidazol-2-yl)-2,2-dimeihylpropyljbenzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-pyridin-2-yl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-pyridin-2-yl-lH-imidazol-2-yl)-2>2-dimethylpropyl]-2,4-difluoroben2amide; N-(3-aminopropyl)-N-[(l R)-l -(l-benzyl-4-pyridin-2-yl- lH-imidazol-2-yl)-2,2-dimethylpropyl]-6-chloronicotiiiamide; N-(2-amino-3-hydroxypropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]benzamide; N-(3-aminopropyl)-N-[(l R)-1 -(1 -benzyl-4-phenyl- lH-imidazol-2-yl)-3-methylbutyl]benzamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-3-methylbutyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(lR,2R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylbutyl]benzamide; N-(3-aminopropyl)-N-[(lR,2R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylbutyl]-4-methylbenzamide; N-(3-ammopropyl)-N-[(lR,2S)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylbutyl]benzamide; N-(3-aminopropyl)-N-[(lR,2S)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-methylbutyl]-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-5-methylisoxazole-4-carboxamide; 268 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} acetamide; N-(3 -aminopropyl)-N- {(1 R)-l -[1 -benzyl-4-(3-chlorophenyl)-1 H-imidazol-2-yl] -2-methylpropyl}-2-(4-fluorophenoxy)acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -2-( 1 H-imidazol-1 -yl)acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-beii2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-morpholin-4-ylacetamide; [(3-{benzoyl[(lR)-l-(l-benzyl-4-phenyl4H-imidazol-2-yl)-2,2-dimethylpropyl]amino}propyl)amino]aceticacid; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-hydroxyacetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl} -2-methoxyacetamide; N-(3 -aminopropyl)-N-[(l R)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy acetamide; N-(3-aminopropyl)-N-[(lR)-l--(l-benzyl-4-phenyl-lH-iinida2X)l-2-yl)-2,2-dimethylpropyl]-2-methoxy acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-l-ethyl-3-metb.yl-lH-pyrazole-5-carboxamide; ethyl [(3-{benzoyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]amino}propyl)amino]acetate; N-{3^(2-amino-3-methylbutanoyl)amino]propyl}-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}tetrahydro-2H-pyran-4-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-(methylamino)acetamide; N-[(lR)-l-(1-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-propylbenzamide; N-[(1R)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-N-butylbenzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-butyl-l,5-dimethyl-lH-pyrazole-3-carboxamide; [[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl](butyl)amino](oxo)aceticacid; 269 WO 2006/002236 PCT/US2005/022062 [[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl](propyl)amino](oxo)aceticacid; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[2-(hydroxymethyl)piperidin-l-yl]propyl}benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-|>is(2-hydroxyethyl)amino]propyl}benzamide; 1 -(2-amino-1 -phenylethyl)-6-(l -benzyl-4-phenyl-1 H-imidazol-2-yl)piperidin-2-one; 6-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)piperidin-2-one; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-iinida2X)l-2-yl)-2,2-dimethylpropyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-iniidazol-2-yl)-2,2-dimethylpropyl]-N-(3-{[2-hydroxy-l-(hydroxymethyl)ethyl]amino}propyl)benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethylpropyl]-N-(3-{[2-(hydroxymethyl)phenyl]amin.o}propyl)benzamide; N-{(lR)-l-[l-ben2yl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-N-piperidin-4-ylbenzamide; N-{(lR)-l-[l-ben2yl-4-(3-chloroplienyl)-lH-imidazol-2-yl]-2-methylpropyl}-N-(piperidin-3-ylmetiiyl)benzamide; 2-(3-amino-2-oxopyridin-l(2H)-yl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-iiiiidazol-2-yl)-2,2-dimethylpropyl]acetamide; N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-pyrrolidin-3-ylbenzamide; (lR,3S)-3-{[(2-anunoethyl)sulfonyl]amino}-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]cyclohexanecarboxamide; (lR,3S)-3-(aminoacetyl)amino]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yi)-2,2-dimethylpropyl]cyclob.exanecarboxamide; N-(3-aininopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-6-(trifluoromethyl)nicotinamide; N-[(2R)-3-ammo-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; (3R)-N-(3-aminopropyI)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}piperidine-3-carboxamide; (3S)-N-(3-aminopropyl)-N-{(lR)-i-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}piperidine-3-carboxamide; 270 WO 2006/002236 PCT/US2005/022062 N-(3-aminopropyl)-N- {(1R)-1 -[1 -benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl]-2-methylpropyl}-2-(lH-l,2,4-triazol-l-yl)acetamide; [(5R)-1 -benzoyl-5-( 1-benzyl-4-phenyl-1 H-imidazol-2-yl)pyrrolidin-2-yl]methylamine; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yI]-2-methylpropyl}-2-(4H-l,2,4-triazol-4-yl)acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2,l,3-benzothiadiazole-4-carboxainide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-1,5-dimethyl-1 H-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l,5-dimethyl-N-[(2S)-raorpholin-2-ylmethyl]-lH-pyrazole-3-carboxamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2!2-diinethylpropyl]-l,5-dimethyl-N-[(2R)-morpholin-2-ylmethyl]-lH-pyrazole-3-carboxamide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(lR)-l-(l-benzyl-4-pIienyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-1,5-dimetihiyl-l H-pyrazole-3-carboxamide; N-[(2S)-3-amino-2-hydroxypropyl]"N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimetiiylpropyl]-2-pyrrolidin-3-ylbenzamide; N-(3-aminopropyl)-N- {(1R)-1-[1 -benzyl-4-(3-chlorophenyl)-lH-imidazol-2-yl]-2-methylpropyl}-2-(lH-pyrazol-l-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l,5-dimetb.yl-lH-pyrazole-3-carboxamide; methyl 3-aminopropyl[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl7lH-imidazol-2-yl)-2J2-dimethylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-(3 -aminopropyl)-N- [(1R)1-(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(l H-1,2,4-triazol-1 -yl)acetamide; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(4H-l,2,4-triazol-4-yl)acetamide; 271 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxy-N-[(2S)-morpholin-2-ylmethyl]acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxy-N-[(2R)-morpholin-2-ylmethyl]acetamide; N-(3-aminopropyl)-N-[(lS)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-hydroxy-2-methylpropyl]benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy-N-[(2S)-morpholin-2-ylmethyl]acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy-N-[(2R)-morpholin-2-ylinethyl]acetamide; (2S)-N-(3-aminopropyl)N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2ryl)-2,2-dimethylpropyl]tetrahydrofuraii-2-carboxatnide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(3-cyanobenzyl)-lH-imidazol-2-yl]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(3-cyanobenzyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(3-methylbenzyl)-lH-imidazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(lR)-l-[4-(3-chlorophenyl)-l-(3-methylbenzyl)-lH-imidazol-2-yl]-2-methylpropyl}benzamide; ethyl 3-aminopropyl[(lR)-l-(l-benzyl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethylpropyljcarbamate; neopentyl3-aminopropyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; isobutyl3-aminopropyl[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; propyl3-aminopropyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-cyanoacetarnide; N-[(1R)-1 -(1 -benzyl-4-phenyl-l H-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-[(lR)-1-(1 -benzyl-4-phenyl- lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; butyl 3-aminopropyl[(lR)-1-(1 -benzyl-4-phenyl-l H-imidazol-2-yl)-2,2-dimethylpropyl]carbamate; 272 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetainide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxy-N-[(3S)-pyrrolidin-3-ylmethyI]acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yi)-2,2-dimethylpropyl]-N-[(3S)-pyrrolidin-3-ylmethyl]benzamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-1-(1 -benzyl-4-phenyl-l H-imidazol-2-yl)-2,2-dimetfiylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N4(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-berizyl-4-phenyl-lH-imida2»l-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-iraidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(2S)-3-aniiiio-2-fluoropropyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-iinidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl3-N-[(3S)-3,4-diamino-4-oxobutyI]benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3R> 3,4-diamino-4-oxobutyl]benzamide; N-[(3S)-3-amko4-hydroxybufyl]-N-[(lR)-l-(l-benzyl-4-pheEyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; (2S)-2-amino-4-{benzoyl[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]amino}butanoic acid; N-[(2R)-3-amko-2-fluoropropyl]-N-[(lR)-l N-(3-aminopropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)2,2-dimethylpropyl]-2-(lH-tetrazol-5-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S)-pyrrolidin-3-ylmethyl]-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S)-pyrrolidin-3-ylmethyI]-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yi)-2,2-dime%lpropyl]-6-methyl-N-[(3S)-pyrrolidin-3-ylmethyl]nicotinamide; N-(azetidin-3-ylmethyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yi)-2,2-dimethylpropyl]-2-methoxyacetamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3-yImethyl)benzamide; 273 WO 2006/002236 PCT/US2005/022062 N-{(lR)-2,2-dimethyl-l-[l-(3-methylbenzyl)-4-phenyI-lH-imidazol-2-yl]propyl}-N-(pyrrolidin-3-ylmethyl)ben2amide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydroxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(methoxyamino)propyl]benzamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-plienyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-2-methoxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyl-lH-imidazoI-2-yl]-2,2-dimethylpropyl}-2-methoxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-cyanoben2yl)-4-pbenyl-lH-iniidazol-2-yl]-2,2-dimethylpropyI}benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimettiylpropyl}-2-methoxyacetamide; 2-hydroxy-N-{(lR)-l-tl-(3-hydroxybenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3-ylmethyl)acetamide; N-{(lR)-2>2-dimethyl-l-[l-(3-methylben2yl)-4-phenyl-lH-imidazoI-2-yl]propyl}-2-methoxy-N-[(3S)-pyrrolidin-3-yhnethyl]acetamide; N-{(lR)-2,2-dimethyl-l-[l-(3-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}-2-methoxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-(3-aminopropyl)-N-{(lR)-2,2-dimethyl-l-[l-(3-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}-2-metboxyacetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l ,5-dimethyl-lH-pyrazole-3-carboxamide; N-(3-amino-2-hydroxypropyl)-N-[(lR)-l-(l-ben2yl-4-phenyI-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-1 -yl)acetamide; N-(3-amino-2-hydroxypropyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-l-(l-benzyl-4-pbenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l,5-dimethyl-N-[(3S)-pyrrolidin-3-ylmethyl]-lH-pyrazole-3-carboxamide; N 274 WO 2006/002236 PCT/US2005/022062 N-(azetidin-3-ylmethyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N N-(azetidin-3-ylmethyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl] -1,5-dimethyl-1 H-pyrazole-3 -carboxamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-l,2,3-triazol-l-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-l,2,3-tria2X)l-2-yl)acetamide; N-[(3S)-3-amino-4-hydroxybu1yl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-l-yI)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(l H-1,2,3-triazol-1 -yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-fluoropyrrolidin-3-yl)methyl]amine; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-hydroxypyrrolidin-3-yl]meihyl}-2-methoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dime1hylpropyl]-N-{[(3R)-3-hydroxypyrrolidin-3-yl]methyl}-2-metb.oxyacetaniide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-252-dimethylpropyl]-N-[(3-hydroxypyrrolidin-3-yl)methyl]-2-methoxyacetamide; N-(azetidin-3-ylmethyl)-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-6-methylnicotinamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-fluoropyrrolidin-3-yl]methyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyMH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-fluoropyrrolidin-3-yl)methyl]-1,5-dimethyl-l H-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-252-dimethylpropyl]-N-{[(3S)-3-fluoropytTolidin-3-yl]methyI}benzamide; 275 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-benzyi-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyl}benzamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dime1iiylpropyl]-N-[(3-fluoropyrrolidin-3-yl)methyl]benzamide; N-(3-aminopropyl)-2-hydroxy-N-{(lR)-l-[l-(3-hydroxyben2yl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl} acetamide; N-{(lR)-l-[l.(3.hydroxybenzyl)-4-(phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-N-(pyrrolidin-3-ylmetiiyl)benzamide; N-(3-aminopropyl)-N-{(lR)-2,2dimethyl-l-[l-(3-methylbenzyl)-4-phenyl-lH-imidazol-2-yl]propyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-{(lR)-2,2-dimethyl-l-[l-(3-methylbenzyl)-4-phenyi-lH-imidazol-2-yl]propyl}-l,5-dimethyl-N-(pyrrolidin-3-ylmethyl)-lH-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-hydroxyben2yl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}benzamide; N-(3 -aminopropyl)-N- {(1R)-1 -[1 -(3-methoxybenzyl)-4-phenyl-1 H-imidazol-2-yl]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-2-methoxy-N-{(lR)-l-[l-(3-methoxybenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}acetamide; N-(3-amiaopropyl)-N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-2-hydroxyacetatnide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-methoxybenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-[(3S)-3-amino-4-methoxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-{(lR)-l-[l-(3-cyanobenzyl)-4-pb.enyl-lH-imidazol-2-yl]-2,2-dimethylpropyl}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N-{(lR)-l-[l-(3-cyanobenzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-diniethylpropyl}-l,5-dimethyl-N-(pyrrolidin-3-ylmethyl)-lH-pyrazole-3-carboxamide; N-{(lR)-l-[l-(3-cyanobenzyl))-4-phenyl-lH-imidazol-2-yl]-2,2-dimethylpropyl>-2-hydroxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyIpropyl]-2-(lH-l,2,3-triazol-l-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-l,2,3-triazol-2-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-hydroxypyrrolidin-3-yl]methyl}benzamide; 276 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-hydroxypyrrolidin-3-yl]methyl}benzamide; N-[(l R)-l -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-hydroxypyrrolidin-3-yl)methyl]benzainide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-ethoxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-(3-aminopropyl)-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-ethoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-hydroxypyrrolidin-3-yl]methyI}-l,5-dimethyl-lH-pyrazole-3-carboxamide; N^(lR)4-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-hydroxypyrrolidin-3-yl]methyl}-l ,5-dimethyl-l H-pyrazole-3-carboxamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2:diinethylpropyl]-N-[(3-hydroxypyrrolidin-3-yl)methyl]-l,5-dimethyl-lH-pyTazole-3-carboxamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lS)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-hydroxy-2-methylpropyl]-2-(l H-tetrazol-1 -yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(lS)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2-hydroxy-2-methylpropyl]-2-(2H-tetra2ol-2-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-{(lR)-l-[l-benzyl-4-(3-fluorophenyl)-lH-iirudazol-2-yl]-2,2-dimethylpropyl}-2-(lH-tetrazol-l-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-{(lR)-l-[l-ben2yl-4-(3-fluorophenyl)-lH-imidazol-2-yl]-2,2-dunethylpropyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(2S)-3-amino-2-(hydroxymethyl)propyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazoI-2-yl)2,2-dimethylpropyll-N'-metiiylethanediamide; N-[(2R)-3-amino-2-(hydroxymethyl)propyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N'-me1iiylethanediamide; N-[(3R)-3-amino-4-hydfoxybutyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3R)-3-amino-4-hydroxybutylJ-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(lH-tetrazol-l-yl)acetamide; N-[(3R)-3-amino-4-hydroxybutyl]-N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2s2-dimethylpropyl]-N-{[(3S)-3-fluoropyrroIidin-3-yl]methyl}-2"methoxyacetaniide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2J2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyl}-2-methoxyacetamide; 277 WO 2006/002236 PCT/US2005/022062 N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S,4S)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R,4R)-4-hydroxypyrrolidin-3 -yl]meihyl}benzamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazoI-2-yl)-2,2-diinethylpropyl]-N-{[(3S,4S)-4-hydroxypyrrolidm-3-yl]methyl}beiizamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-{(lR)-l-[l-benzyl-4-(3-fluorophenyl)-lH-iinidazol-2-yl]-2,2-dimethylpropyl}-2-(lH-tetra2X)l-l-yl)acetaniide; N-[(3S)-3-amino-4-hydroxybutyl]-N-{(lR)-l-[l-benzyl-4-(3-fluorophenyl)-lH-imidazol-2-yl]-2,2-dimet]iylpropyl}-2-(2H-tetrazol-2-yl)acetamide; N4(3S)-3-amino-4-methoxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-metiioxyacetanaide; N-[(3S)-3-amino-4-hydroxybutyl]-N-{(lR)-l-[l-benzyl-4-(3-fluorophenyl)-lH-imidazol-2-yl]-2,2-dimethylpropyI}-2-methoxyacetamide; N-KlR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-fluoropyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-l-(l-benzyl-4-pheny1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3-fluoropyrrolidin-3-yl]methyl}-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S,4S)-4-hydroxypyirolidin-3-yl]methyl}-2(lH-tetra2ol-l-yl)acetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyIpropyl]-N-{[(3S,4SH-hydroxypyrroHdm-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R,4R)4-hydroxypyirolidin-3-yl3methyl}-2-(lH-tetrazol-l-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimeth.yIpropyl]-N-{[(3R,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetainide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimeihylpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrroUdin-3-yl}methyl}-2-(2H-tetrazol-2-yl)acetaimide; N-[((1R)-1-(1-benzyl-4-phenyl-lH-imidazol-2-yl)2,2-dimethylpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-(lH-tetrazol-l-yl)acetaniide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yI)-2,2-dimethyIpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yI]methyl}benzamide; 278 WO 2006/002236 PCT/US2005/022062 N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(5-methyl-2H-tetrazol-2-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-(5-methyl-lH-tetrazol-l-yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R)-3 -hydroxypyrrolidin-3 -yl]methyl}-2-(l H-tetrazol-1 -yl)acetamide; N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S)-3-hydroxypyrrolidin-3-yl]methyl}-2-(lH-tetrazol-l-yl)acetamide; (5S)-3-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l-oxa-3,7-diazaspiro[4.4]nonan-2-one; (5R)-3-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-l-oxa-3,7-diazaspiro [4.4]nonan-2-one; N-[(2S,3R)-3-amino-2-fluoro-4-hydroxybutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3S)-3-amino-4-fluorobutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3R)-3-amino-4-fluorobutyl]-N-[(lR)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R>4S)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(lR)-l-(l-benzyl-4-phenyHH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3S,4R)-4-hydroxypyrrolidin-3-yl3methyl}-2-meHioxyacetamide; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3R,4S)-4-fluoropyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(lR)4-(l-benzyl-4-phenyl-lH-inudazol-2-yl)-2,2-dimethylpropyl]-N-(2,5-dihydro-lH-pyrrol-3-ylmethyl)-2-methoxyacetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-benzyl-4-pyrazin-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(3-methoxy-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-fiiran-2-carboxylicacid((R)-3-amino-2-fluoro-propyl)-[(R)-l-(l-benzyl-4-pyrazm-2-yHH-imidazol-2-yl)-2,2-dimethyl-propyl]-amide; N-((R)r3-Amino-2-fl-uoro-propyl)-N-[(R)-l-(l-benzyl-4-pyrazin-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-ethoxy-acetamide; 279 WO 2006/002236 PCT/US2005/022062 N-((R)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-ethoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-1 -(1 -benzyl-4-phenyl-1 H-imidazol-2-yl)-2,2-dimethyl-propyl]-amide; N-((S)-3-Amino-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-1 -(4-phenyl-1 -pyridin-3-ylmethyl-1 H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; NK(R)-3-Amino-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyl-l-pyridin-3-ylmethyl-1 H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N-((S)-3-Amino-4-methoxy-butyl)-N-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(4-cyano-phenyl)-lH-imidazol-2-yl]2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(4-methoxy-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((lR)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(2-fluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(3-chloro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-(3-cyano-benzyl)-4-phenyl-lH-imidazol-2-yI]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyI-l -[4-phenyl-l -(tetrahydro-pyran-4-yImethyI)-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-l-[l -benzyl-4-(3-fIuoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-l -[1 -benzyl-4-(2-methoxy-phenyl)-1 H-imidazol-2-yl]-2,2-dimethyl-propyl} -amide; (S)-Tetrahydro-furan-2-carboxylicacid((R)-3-amino-2-fluoro-propyl)-{(R)-l-[l-benzyl-4-(3-trifluoromethyl-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-l -[1 -benzyl-4-(3-bromo-phenyl)-lH-iniidazol-2-yl]-2,2-dimethyl-propyl}-amide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(2-methoxy-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; 280 WO 2006/002236 PCT/US2005/022062 N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(3-trifluoromethyl-phenyl)-1 H-imidazol-2-yl] -2,2-dimethyl-propyl} -2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-N-{(R)-l-[l-benzyl-4-(3-bromo-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetainide; N-((R)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-benzyl-4-p-tolyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N-((S)-3-Ammo-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyl-l-pyridin-4-ylmethyl-1 H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyl-l-pyridin-4-ylmethyl-lH-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-2,2-dimethyl-l-[l-(5-methyl-isoxazx)l-3-ylmethyl)-4-phenyl-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-2,2-dimethyl-l-[l-(5-methyl-isoxazol-3-ylmethyl)-4-phenyl-1 H-imidazol-2-yl]-propyl} -2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-[(R)-2J2-dimethyl-l-(4-phenyl-l-pyridin-2-ylmethyl-lH-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N-((R)-3-Arnko-4-fluoro-butyl)-N-[(R)-2,2-dimethyl-l-(4-phenyl-l-pyridin-2-ylmethyl-lH-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-diniethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-(3-Amino-3-methyl-butyl)-N-[(R)-l-(l-benzyl-4-phenyl-lH-imidazoI-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid((R)-3-amino-2-flTioro-propyl)-[(R)-l-(l-ben2yl-5-chloro-4-phenyl-lH-imidazol-2-yl)-2^-dimetiiyl-propyl]-amide; N-((R)-3-Amino-2-fluoro-prdpyl)-N-[(R)-l-(l-ben2yl-5-chIoro-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl3-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-l -(1 -ben2yl-4-thiazol-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-amide; N-((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-1-[4-phenyl-l-(5-trifluoromethyl-fean-2-ylmethyl)-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-2-fIuoro-propyl)-N-{(R)-2,2-dimethyl-l-[l-(5-methyl-isoxazol-3-ylmethyl)-4-phenyl-1 H-imidazol-2-yl]-propD yl} -2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-2-fluoro-propyl)- {(R)-2,2-dimethyl-l-[l-(5-methyl-isoxazol-3-ylmethyl)-4-phenyl-lH-imidazol-2-yl]-propyl}-amide; 281 WO 2006/002236 PCT/US2005/022062 (S)-Tetrahydro-furan-2-carboxylicacid((S)-3-amino-2-fluoro-propyl)-{(R)-2,2-dimethyl-1-[4-phenyM-(5-trifluoromethyl-furan-2-ylmethyl)-1H-imidazol-2-yl]-propyl}-amide; N-((S)-3-Amino-4-methoxy-butyl)-N-{(R)-l-[l-(3-fluoro-ben2yl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-4-hydroxy-butyl)-N- {(R)-l -[1 -(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(2,5-difluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(2,5-difluoro-benzyl)-4-phenyl-lH-imidazol-2-yl]-2,2-diinethyl-propyl}-2-methoxy-aoetamide; N-((R)-3-Ainino-2-fluoro-propyl)-N-{(R)-l-[l-(4-fluoro-benzyl)-4-phetiyl-lH-imidazol-2-yl]-2,2-diinethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-2-fluoro-propyl)-2-methoxy-N-{(R)-l-[l-(3-methoxy-benzyl)-4-phenyl-lH'imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; N N N-((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-l-[l-(3-raethyl-benzyl)-4-phenyl-lH-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N-[(R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propylj-acetamide; N-((S)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-ben2yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amiuo-2-fluoro-propyl)-[(R)-l -(1 -ben2yl-lH-irnidazol-2-yl)-2,2-dimethyI-propyl]-amide; N-((S)-3-Amino-4-fluoro-bufyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-2-fluoro-propyl)-N-[(R)-l-(l-benzyl-4-thiazol-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-[2-(l-Amino-cyclopropyl)-ethyl]-N-[(R)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid[2-(l-amino-cyclopropyl)-ethyl]-[(R)-l-(1 -ben2yl-4-phenyl-l H-imidazol-2-yl)-2,2-dimethyI-propyl]-amide; 282 WO 2006/002236 PCT/US2005/022062 [2-(l-Atnino-cyclopropyl)-ethyl]-[(R)-l-(l-benzyl-4-phenyl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-carbamic acid methyl ester; N-[2-(l-Amino-cyclopropyl)-ethyl]-N-{(R)-l-[l-benzyl-4-(3-fluoro-phenyl)-lH-imidazoyl-2-yl]-2,2-dimethyl-propyl}-2-metiioxy-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid[2-(l-amino-cyclopropyl)-ethyl]-{(R)-l-[l-ben2yl-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; N-(3-Amino-propyl)-N-{(R)-l-[l-ben2yl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimetb.yl-propyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N-{l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-l-methyl-ethyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2^2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-4-fluoro-butyl)-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-iitudazol-2-yl]-2,2-dimethyl-propyl}-amide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-benzyl-5-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methoxy-acetamide; N-((S)-3-Amino-4-methoxy-butyl)-N-{(R)-l-[4-(3-chloro-phenyl)-l-(3-fluoro-ben2yl)-lH-iinidazol-2-yl]-2-meth.yl-propyl}-2-methoxy-acetamide; N N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[4-(3-chloro-phenyl)-l-(3-fluoro-ben2yl)-lH-imidazol-2-yl]-2-methyl-propyl}-2-methoxy-acetamide; N-(3-Amino-4-fluoro-butyl)-N-{l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-iinidazol-2-yl]-1 -methyl-ethyl}-2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; (S)-Tetrahydro-furan-2-carboxylicacid((S)-3-amino-2-fluoro-propyl)-{(R)-l-[l-(3-fluoro-benzyl)-4K3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (R)-9-{(R)-l-[l-(3-Fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-6-oxa-2,9-diaza-spiro[4,5]decan-8-one; 283 WO 2006/002236 PCT/US2005/022062 (3-Amino-4-fluoro-butyl)-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-formamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-1 H-imidazol-2-yl] -2,2-dimethyl-propyl} -formamide; N-(3-Dimethylamino-propyl)-N-{(R)-l-[l-(3-fluoro-benzyI)-4-(3-fluoro-phenyl)-1 H-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methoxy-acetamide; N-((S)-3-Amino-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; NK(R)-3-Amino-butyl)-N-{(R)-l-[l-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Ambo-4-fluoro-butyl)-N-{(R)-l-[1-(6-amino-pyridin-2-ylmethyl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fliioro-butyl)-N-{(R)-l-[l-(6-amino-pyridin-2-ylmethyl)-4-(3-fluoro-phenyl)-1 H-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methoxy-acetamide; N-((S)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[4-(3-fluoro-phenyl)-l-(3-hydroxy-benzyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((R)-3-Amino-4-fluoro-butyl)-N-{(R)-l-[4-(3-fluoro-phenyl)-l-(3-hydroxy-benzyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-((S)-3-Aiiuno-4-fluoro-butyl)-N-[(R)-l-(l-benzyl-4-thiazol-2-yl-lH-imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N-{(R)-l-[l-(3-Fluoro-ben2yl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yi]-252-dimethyl-propyl}-2-methoxy-N-(3-methylamino-propyl)-acetamide; N-(3-Amino-propyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl} -acetamide; (3-Amino-propyl)-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; (S)-Tetrahydro-furan.-2-carboxylic acid (3-amino-propyl)-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; 3-[{(R)-l-[l-(3-Fluoro-ben2yl)-4-(3-fluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-(2-methoxy-acetyl)-amino]-propionamide; N-(3-Amino-propyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl} -2-methanesulfonyl-acetamide; N-((S)-3-Amino-4-methoxy-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; 284 WO 2006/002236 PCT/US2005/022062 (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-4-fluoro-butyl)- {(R)-1 -[ 1 -benzyl-4-(2,5-difluoro-phenyl)-1 H-imidazol-2-yl] -2,2-dimethyl-propyl} -amide; (R)-l-[l-Benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propylamine; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3 -amino-4-methoxy-butyl)- { (R)-1 -[l-beiizyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; N-((R)-3-Amino-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difiuoro-phenyl)-lH-imidazol-2-yl]-252-dimethyl-propyl}-2-me1hoxy-acetamide; N-((S)-3-Amino-butyl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--{(R)-l-[l-Benzyl-4-(2,5-difluoro-phenyl)-lH-iinidazol-2-yl]-2,2-dim6thyl-propyl}-2-methoxy-N-(lH-[l^l,3]triazol-4-ylmethyl)-acetamide; N-((S)-3-Amino-4-fluoro-bu1yl)-N-{(R)-l-[l-benzyl-4-(2,5-difluoro-phenyl)-lH-imidazx3l-2-yl]-2,2-dimethyl-propyl}-acetamide; ((S)^-Amino-4-fluoro-butyl)-{(R)-l-[l-benzyl-4-(235-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; {(R)-l-[l-Benzyl-4-(2,5-difluoro-phenyl)-lH-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid tert-butyl ester; N-[(lR)-l-(l-ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-t(l R)-l -(1 -ben2yl-4-phenyl-lH-imidazol-2-yl)-2-methylpropyl]-2-(4-fluorophenoxy)acetamide; and pharmaceutically acceptable salts thereof. 23. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier. 24. The composition of claim 23 further comprising at least one additional agent for the treatment of cancer. 25. The composition of claim 23, wherein the additional agent for the treatment of cancer is selected from the group consisting of irinotecan, topotecan, gemcitabine, imatinib, trastuzumab, 5-fluorouracil, leucovorin, carboplatin, cisplatin, docetaxel, paclitaxel, tezacitabine, cyclophosphamide, vinca alkaloids, anthracyclines, rituximab, and trastuzumab. 285 WO 2006/002236 PCT/US2005/022062 26. A method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a composition of claim 23. 27. The method of claim 26, wherein the disorder is a cellular proliferative disease. 28. The method of claim 27, wherein the cellular proliferative disease is cancer. 29. The method of claim 28, wherein the cancer is selected from the group consisting of lung and bronchus; prostate; breast; pancreas; colon and rectum; thyroid; stomach; liver and intrahepatic bile duct; kidney and renal pelvis; urinary bladder; uterine corpus; uterine cervix; ovary; multiple myeloma; esophagus; acute myelogenous leukemia; chronic myelognous leukemia; lymphocytic leukemia; myeloid leukemia; brain; oral cavity and pharynx; larynx; small intestine; non-hodgkin lymphoma; melanoma; and villous colon adenoma. 30. The method of claim 29 further comprising administering to the mammalian patient one additional agent for the treatment of cancer. 31. The method of claim 30, wherein the additional agent for the treatment of cancer is selected from the group consisting of irinotecan, topotecan, gemcitabine, imatinib, trastuzumab, 5-fluorouracil, leucovorin, carboplatin, cisplatin, docetaxel, paclitaxel, tezacitabine, cyclophosphamide, vinca alkaloids, anthracyclines, rituximab, and trastuzumab. 32. A method for inhibiting KSP kinesin in a mammalian patient, wherein said method comprises administering to the patient an effective KSP-inhibiting amount of a compound of claim 1. 33. Use of the composition of claim 23 in the manufacture of a medicament for the treatment of cancer. 286

Documents:

00144-kolnp-2007 abstract .pdf

00144-kolnp-2007 assignment.pdf

00144-kolnp-2007 claims.pdf

00144-kolnp-2007 correspondence others.pdf

00144-kolnp-2007 description (complete).pdf

00144-kolnp-2007 form-1.pdf

00144-kolnp-2007 form-3.pdf

00144-kolnp-2007 form-5.pdf

00144-kolnp-2007 international publication.pdf

00144-kolnp-2007 international search authority report.pdf

00144-kolnp-2007 pct form.pdf

00144-kolnp-2007-assignment-1.1.pdf

00144-kolnp-2007-correspondence-1.1.pdf

00144-kolnp-2007-form-3-1.1.pdf

144-KOLNP-2007-ABSTRACT.pdf

144-KOLNP-2007-AMANDED CLAIMS.pdf

144-KOLNP-2007-ASSIGNMENT.pdf

144-KOLNP-2007-CORRESPONDENCE.pdf

144-KOLNP-2007-DESCRIPTION (COMPLETE).pdf

144-KOLNP-2007-EXAMINATION REPORT.pdf

144-KOLNP-2007-FORM 1.pdf

144-KOLNP-2007-FORM 13 1.2.pdf

144-KOLNP-2007-FORM 13-1.1.pdf

144-KOLNP-2007-FORM 13.pdf

144-KOLNP-2007-FORM 18 1.1.pdf

144-kolnp-2007-form 18.pdf

144-KOLNP-2007-FORM 2.pdf

144-KOLNP-2007-FORM 3 1.1.pdf

144-KOLNP-2007-FORM 3.pdf

144-KOLNP-2007-FORM 5 1.1.pdf

144-KOLNP-2007-FORM 5.pdf

144-KOLNP-2007-GPA.pdf

144-KOLNP-2007-GRANTED-ABSTRACT.pdf

144-KOLNP-2007-GRANTED-CLAIMS.pdf

144-KOLNP-2007-GRANTED-DESCRIPTION (COMPLETE).pdf

144-KOLNP-2007-GRANTED-FORM 1.pdf

144-KOLNP-2007-GRANTED-FORM 2.pdf

144-KOLNP-2007-GRANTED-SPECIFICATION.pdf

144-KOLNP-2007-OTHERS 1.1.pdf

144-KOLNP-2007-OTHERS.pdf

144-KOLNP-2007-PETITION UNDER RULE 137.pdf

144-KOLNP-2007-REPLY TO EXAMINATION REPORT 1.1.pdf

144-KOLNP-2007-REPLY TO EXAMINATION REPORT.pdf

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