Title of Invention

A PROCESS FOR PREPARATION OF METHYL-(+)-(S)-ALPHA-(2-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)-ACETIC ACID METHYL ESTER AS FREE BASE

Abstract

A process for preparation of methyl-(+)-(S)-alpha-(2-chlorophenyl) –6,7-dihydrothieno [3,2-c] pyridine-5 (4H)-acetic acid methyl ester or salts thereof [clopidogrel or salts thereof of Formula –I] having higher chiral purity and products thereof is provided. A process for purification of the compound prepared is also provided to enhance its efficacy by enhancing its optical rotation and chiral purity. In Formula –I, R is selected from a group comprising alkyl, alkoxy. hydroxy, amine etc., and R1 is selected from the group comprising C1-4 alkyl, C1-4 alkoxy, hydroxy, nitro & halogen. The particular salt of interest of the present invention is the hydrogen sulfate of compound of the Formula – I, wherein R and R1 are –OCH3 and chloro - group at position 2 respectively.

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