Title of Invention

INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS VIA RECEPTOR ANTAGONISTS

Abstract

This invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as VIa receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1 , R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders, and methods of preparation thereof.

Full Text

,d ._ 1 .__• T^d or by -NH(CO)R , wherein R is C1-6-alkyl optionally substituted by halo or nitro, or Rd is aryl or a 5 or 6 membered heteroaryl, which are optionally substituted by halo, nitro,C1-6-alkyl or C1-6-haloalkyl; A R4 is one or more of H, halo, C1-6-alkyl or C1-6-alkoxy optionally substituted by A OH, or two R may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R'5 is H, C1-6-alkyl or aryl; R6 is H orC1-6-alkyl; R7 is H or -SO2-Re' wherein Re is C1-6-alkyl or aryl; R8 isHorC1-6-alkyl; X is CH2 or C=0; B is halo, CN, NR*R",C1-6-alkyl optionally substituted by CN, halo or C1-6-alkoxy, C1-6-alkoxy, C1-6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-Ci.6-alkyl, -C(0) NR*R', -C(0)-C1-6-alkyl, -S(0)2-C1-6-alkyl, -8(0)2- NR'R", (CR'"R*")n-phenyl, or (CR"'R'^)n-5 or 6 membered heteroaryl wherein the phenyl or 5 or 6 membered heteroaryl moiety is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, CN, NR'R", C1-6-alkyl optionally substituted by CN, halo orC1-6-alkoxy, C1-6-alkoxy, C1-6-haloalkoxy, C3.6-cycloalkyl, -C(0)0-Ci_6-aIkyl, -C(0)-NR'R", -C(0)-C]^-alkyl, -S(0)2-C1-6-alkyl, -8(0)2- NR'R"; R' and R" are H, C1-6-alkyl, C]-6-alkyl-NR"'R*\ -(CO)O-C1-6-alkyl, -C(0)-NR''R*\ -C(0)-C1-6-alkyl, -8(0)2-Ci.6-alkyl, -8(0)2- NR''R'^ or OH; R'" and R'" are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. The compounds of formula (I) may contain some asymmetric carbon atoms. Accordingly, the present invention includes all stereioisomeric forms of the compounds of formula (I), including each of the individual enantiomers and mixtures thereof. It has been found that the compounds of formula (I) have a good activity on the Via receptor. Therefore, the invention provides the use of a compound of formula (1) or a pharmaceutically acceptable salt thereof in the manufacture of medicaments for the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders. Vasopressin is a 9 amino acid peptide mainly produced by the paraventricular nucleus of the hypothalamus. Three vasopressin receptors, all belonging to the class I G-protein coupled receptors, are known. The Via receptor is expressed in the brain, liver, vascular smooth muscle, lung, uterus and testis, the VI b or V3 receptor is expressed in the brain and pituitary gland, the V2 receptor is expressed in the kidney where it regulates water excretion and mediates the antidiuretic effects of vasopressin. In the periphery vasopressin acts as a neurohormone and stimulates vasoconstriction, glycogenolysis and antidiuresis. In the brain vasopressin acts as a neuromodulator and is elevated in the amygdala during stress ( Ebner, K., C. T. Wotjak, et al. (2002). "Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats." Eur J Neurosci 15(2): 384-8). The Via receptor is extensively expressed in the brain and particularly in limbic areas like the amygdala, lateral septum and hippocampus which are playing an important role in the regulation of anxiety. Indeed Via knock-out mouse show a reduction in anxious behavior in the plus-maze, open field and light-dark box ( Bielsky, I. F., S. B. Hu, et al. (2003). "Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin Via Receptor Knockout Mice." NeuropsvchopharmacologvV The downregulation of the Via receptor using antisense oligonucleotide injection in the septum also causes a reduction in anxious behavior ( Landgraf, R., R. Gerstberger, et al. (1995). "VI vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats." Regul Pept 59(2): 229-39). The Via receptor is also mediating the cardiovascular effects of vasopressin in the brain by centrally regulating blood pressure and heart rate in the solitary tract nucleus (Michelini, L. C. and M. Morris (1999). "Endogenous vasopressin modulates the cardiovascular responses to exercise." Ann N Y Acad Sci 897:198-211). In the periphery it induces the contraction of vascular smooth muscles and chronic inhibition of the Via receptor improves hemodynamic parameters in myocardial infarcted rats ( Van Kerckhoven, R., I. Lankhuizen, et al. (2002). "Chronic vasopressin V(1A) but not V(2) receptor antagonism prevents heart failure in chronically infarcted rats." Eur J Pharmacol 449(1-2): 135-41). Thus vasopressin receptor antagonists are useful as therapeutics in the conditions of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders. The preferred indications with regard to the present invention are the treatment of anxious and depressive disorders. As used herein, the term "aryl" means a monovalent cyclic aromatic hydrocarbon moiety consisting of a mono-, bi- or tricyclic aromatic ring. Examples of aryl moieties include, but are not limited to, optionally substituted phenyl, naphthyl, phenanthryl, fluorenyl, indenyl, pentalenyl, azulenyl, oxydiphenyl, biphenyl, methylenediphenyl, aminodiphenyl, diphenylsulfidyl, diphenylsulfonyl, diphenylisopropylidenyl, benzodioxanyl, benzofuranyl, benzodioxylyl, benzopyranyl, benzoxazinyl, benzoxazinonyl, benzopiperadinyl, benzopiperazinyl, benzopyrrolidinyl, benzomorpholinyl, methylenedioxyphenyl, ethylenedioxyphenyl, as well as those specifically illustrated by the examples herein below. Substituents for aryl include but are not limited to halogen, Cj.6-alkyl, C1-6-alkoxy as well as those specifically listed and illustrated by the description and examples herein below. Preferred aryl are phenyl and naphthyl and still preferably phenyl. The term "C1-6-alkyr' denotes a saturated straight- or branched-chain group containing from 1 to 6 carbon atoms, for example, methyl, ethyl, propyl, isopropyl, n-butyl, i-butyl, 2-butyl, t-butyl and the like. Preferred C1-6-alkyl groups are CM-groups, i.e. with 1-4 carbon atoms. The term "C1-6-alkoxy" denotes a group wherein the alkyl residues are as defined above, and which is attached via an oxygen atom. PreferredC1-6-alkoxy groups are methoxy and ethoxy as well as those specifically illustrated by the examples herein below. The term "C2-6-alkenyr' denotes a carbon chain of 2 to 6 carbon atoms comprising a double bond in its chain. C2-6-alkenyl groups include ethenyl, propen-1-yl, propen-2-yl, buten-1-yI, buten-3-yI, penten-1-yl, penten-2-yl, penten-3-yl, penten-4-yl, hexen-l-yl, hexen-2-yl, hexen-3-yl, hexen-4-yl and hexen-5-yl, as well as those speC1-6fically illustrated by the examples herein below. The term "benzyloxy" denotes a benzyl group attached via an oxygen atom. The term "halogen" or "halo" denotes chlorine (C1-6), iodine (1), fluorine (F) and bromine (Br). The term "C1-6.6-haloalkyl" denotes aC1-6-alkyl group as defined above which is substituted by one or more halogen. Examples of C1-6-haloalkyl include but are not limited to methyl, ethyl, propyl, isopropyl, isobutyl, sec-butyl, tert-butyl, pentyl or n-hexyl substituted by one or more C1-6, F, Br or I atom(s) as well as those groups speC1-6fically illustrated by the examples herein below. PreferredC1-6-haloalkyl are difluoro- or trifluoro-methyl or ethyl. "C1-6-haloalkoxy" denotes a C1-6-alkoxy group as defined above which is substituted by one or more halogen. Examples of C1-6-haloalkoxy include but are not limited to methoxy or ethoxy, substituted by one or more C1-6, F, Br or I atom(s) as well as those groups speC1-6fically illustrated by the examples herein below. Preferred C1-6-haloalkoxy are difluoro- or trifluoro-methoxy or ethoxy. The term "C3-6-cycloalkyr' denotes a monovalent or divalent saturated carbocyclic moiety consisting of a monocyclic ring. Cycloalkyl can optionally be substituted with one, two, three or four substituents, wherein each substituent is independently hydroxy, C1-6-alkyl, C1-6-alkoxy, halogen, amino, unless otherwise speC1-6fically indicated. Examples of cycloalkyl moieties include optionally substituted cyclopropyl, optionally substituted cyclobutyl, optionally substituted cyclopentyl and optionally substituted cyclohexyl as well as those speC1-6fically illustrated by the examples herein below. The term "3 to 7 membered heterocycloalkyl" means a monovalent saturated moiety, consisting of one ring of 3 to 7 atoms as ring members, including one, two, or three heteroatoms chosen from nitrogen, oxygen or sulfur, the rest being carbon atoms. 3 to 7 membered heterocycloalkyl can optionally be substituted with one, two, three or four substituents, wherein each substituent is independently hydroxy, C1-6-alkyl, C1-6-alkoxy, C1-6-fi-thioalkyl, halo, C1-6-haloalkyl,C1-6-hydroxyalkyl, alkoxycarbonyl, amino,C1-6- alkylamino, di(C]^)alkylamino, aminocarbonyl, or carbonylamino, unless otherwise speC1-6fically indicated. Examples of heterocyclic moieties include, but are not limited to, oxirane, optionally substituted oxetane, optionally substituted tetrahydro-furanyl, optionally substituted piperidinyl, optionally substituted pyrrolidinyl, optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted azepane or homopiperazine, and the like or those which are speC1-6fically exemplified herein. Substituents can be selected from C1-6-alkyl, C1-6-alkoxy, C1-6-haloalkyl, halo, CN, OH, NH2, as well as those substituents which are are speC1-6fically illustrated in the examples hereinafter. The term "5 or 6 membered heteroaryl" means an aromatic ring of 5 or 6 ring atoms as ring members containing one, two, or three ring heteroatoms selected from N, O, or S, the rest being carbon atoms. 5 or 6 heteroaryl can optionally be substituted with one, two, three or four substituents, wherein each substituent is independently hydroxy, C1-6-alkyl,C1-6-alkoxy, C1-6-thioalkyl, halo, C1-6-haloalkyl, C1-6-hydroxyalkyl, alkoxycarbonyl, amino, C1-6-alkylamino, di(C1-6_6)alkylamino, aminocarbonyl, or carbonylamino, unless otherwise speC1-6fically indicated. Examples of heteroaryl moieties include, but are not limited to, optionally substituted imidazolyl, optionally substituted oxazolyl, optionally substituted thiazolyl, optionally substituted pyrazinyl, optionally substituted pyrrolyl, optionally substituted pyrazinyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted furanyl, and those which are speC1-6fically exemplified herein. The term "sulfonylaryl" denotes an aryl group as defined hereinabove which is attached via a sulfonyl group. 'I The expression "two R may form an 0x0 or dioxo bridge together with the indole ring to which they are attached notes an 0x0 or dioxo bridge of the following formulae: which bind two adjacent carbon atoms of the phenyl or indole ring of the compound of formula (I) to which either R^ is binding. Examples of group illustrating the expression "R^ and R'^ together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by =0. C(0)0-C1-6_6-alkyl orC1-6-alkyl" are: The term "pharmaceutically acceptable aC1-6d addition salts" embraces salts with inorganic and organic aC1-6ds, such as hydrochloric aC1-6d, nitric aC1-6d, sulfuric aC1-6d, phosphoric aC1-6d, C1-6tric aC1-6d, formic aC1-6d, fumaric aC1-6d, maleic aC1-6d, acetic aC1-6d, sucC1-6nic aC1-6d, tartaric aC1-6d, methane-sulfonic aC1-6d, p-toluenesulfonic aC1-6d, as well as those speC1-6fically illustrated by the examples herein below. In a certain embodiment, the compounds of formula (I) are those compounds wherein: A is selected from (a), (b), (c), (d), (e), (f), (g) or (h) and wherein R^ is H, or is Gi.6-alkyl optionally substituted by CN, or is aryl, 5 or 6 membered heteroaryl or sulfonylaryl which are optionally substituted by one or more B, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR^R", C3_6-cycloalkyl, 3 to 7 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(CO)-R*' or -(CH2)n-(S02)-R\ wherein R^ is: C1-6-alkoxy, NR'R", 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroarylwhich are optionally substituted by one or more B, 1 % or R and R together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by =0, C(0)0-C1-6_6-alkyl or C1-6-alkyl; R is one or more of H, OH, halo,C1-6-alkyl optionally substituted by -NR'"R'^, C^,- alkoxy; R^ is H, or is halo or is -(CO)-R^ wherein R^ is: C1-6-alkyl -(CH2)n-NR'R", -(CH2)n-NR'"R*5 or 6 membered heterocycloalkyl optionally substituted by C1-6-alkyl, or is C1-6-alkyl or aryl, which are optionally substituted by halo, R"^ is is one or more of H, halo, or C1-6-alkoxy optionally substituted by OH, or two R*^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ is H or aryl; R^ is H; R'^ is H or -SO2-R' wherein R^ is C1-6_6-alkyl or aryl; R** isHorC1-6-alkyl; X is CH2 or C=0; B is halo, CN, NH2, C1-6^alkyl optionally substituted by CN or C1-6-alkoxy, C1-6- alkoxy, d^-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6-alkyl, -(CR"'R'')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo,C1-6-alkyl optionally substituted by CN or halo, C1-6_6-alkoxy; R' and R" are H, C1-6-alkyl, C]^-alkyl-NR'"R*^ -(C0)0-C1-6.6-alkyl, -C(0)-NR"'R'\ -C(0)- C]_6-alkyl, -S(0)2-C1-6.6-alkyl or -S(0)2- NR"'R' or OH; R"' and R*' are H or C1-6_6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. In another embodiment, the compounds of formula (I) are those compounds wherein: A is selected from (a), (b), (c), (d) or (e), and wherein R^ is H, or is C1-6-alkyl optionally substituted by CN, or is aryl, 5 or 6 membered heteroaryl or sulfonylaryl which are optionally substituted by one or more B, or is -(CH2)ni-R^ wherein R^ is: CN, OR', NR'R", C3-6-cycloalkyl, 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^ or -(CH2)n-(S02)-R^ wherein R' is: C1-6-alkyl, C1-6_fi-alkoxy, C3.6-cycloalkyI, -(CH2)m-NR"'R'\ NR*R", C3-6-cycloalkyl, 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or R and R together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by (CO); R^ is one or more of H, OH, halo, CN, nitro, C1-6-alkyl optionally substituted by -NR'"R^ C^-alkoxy, -0-CH2-C2-:6-alkenyl, benzyloxy, or two R may form an oxo or dioxo bridge together with the indole ring to which they are attached; R^ is H, or is halo, or is -(CO)-R^ wherein R^ is: C1-6-alkyl, -(CH2)n-NR^R^ -(CH2)n-NR'"R'5 or 6 membered heterocycloalkyl optionally substituted byC1-6-alkyl, or isC1-6-alkyl or aryl, which are optionally substituted by halo, -0(CO)-C1-6-alkyl, or by -NH(CO)R^, wherein R^ is C1-6-aIkyl optionally substituted by halo or nitro, or R is aryl or a 5 or 6 membered heteroaryl, which are optionally substituted by halo, nitro, C1-6_6-alkyl or C1-6-haloalkyl; R is one or more of H, halo, C1-6-alkyl orC1-6-alkoxy or two R'* may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ is H, C1-6-alkyl or aryl; R^ is H orC1-6-alkyl; R^ is H or -S02-R^ wherein R^ is C1-6-alkyl or aryl; B is halo, CN, NR^R", C1-6-alkyl optionally substituted by CN, halo orC1-6-alkoxy, C1-6-alkoxy, C1-6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6-alkyl, -C(0) NR'R", -C(0)-C1-6-alkyl, -S(0)2-C1-6-alkyl, -S(0)2- NR*R", (CR"'R*Vphenyl, or (CR"'R'^)n-5 or 6 membered heteroaryl wherein the phenyl or 5 or 6 membered heteroaryl moiety is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, CN, NR*R",C1-6-alkyl optionally substituted by CN or C1-6-alkoxy, C1-6_6-alkoxy, C1-6_6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6.6-alkyl, -C(0)-NR'R", -C(0)-C1-6.6-alkyl, -S(0)2-C1-6-alkyl, -S(0)2- NR'R'; R' and R" are H, C1-6-alkyl, C1-6-alkyl-NR'"R'\ -(C0)0-C1-6-alkyl, -C(0)-NR"'R*\ -C(0)- C1-6-alkyl, -S(0)2-C1-6-alkyl or -S(0)2- NR'"R'^; R'" and R*^ are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. In another embodiment, the compounds of formula (I) are those compounds wherein: A is selected from (a), (b), (c), (d) or (e), and wherein R^ is H, or is C1-6_6-alkyl, or is aryl, 5 or 6 membered heteroaryl or sulfonylaryl which are optionally substituted by one or more B, or is -(CH2)m-R^ wherein R"* is: CN, NR^R", C3-6-cycloalky], 4 to 7 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R' or -(CH2)n-(S02)-R\ wherein R^ is: C1-6-alkoxy, NR'R", 4 to 7 membered-heterocycloalkyl, aryl, which are optionally substituted by one or more B, or R' and R^ together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by (CO); R is one or more of H, OH, halo, Cj-6-alkyl optionally substituted by ~NR'"R'^, C1-6- alkoxy; R^ is H, or is -(CO)-R^ wherein R"" is: -(CH2)n-NR^R'\ -(CH2)n-NR"'R'5 or 6 membered heterocycloalkyl optionally substituted by C1-6-alkyl, or is C1-6-alkyI or aryl, which are optionally substituted by halo, R\ R^ and R^ are H; R^ is H or -SO2-R' wherein R' is d^-alkyl or aryl; B is halo, NH2, C1-6-alkyl optionally substituted by CN orC1-6-alkoxy, C1-6-alkoxy, C1-6_6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6.6-alkyl, -(CR"'R'On-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo, C1-6-alkoxy; R' and R" are H, C^-alkyl, C1-6-alkyl-NR"'R'\ -(C0)0-C1-6-alkyl, -C(0)-NR"'R*\ -C(0)- C1-6-aIkyl, -S(0)2-C1-6.6-alkyl or -S(0)2- NR'"R"^; R'" and R'^ are H or C1-6_6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. In another embodiment, the compound of formula (I) are those compounds wherein: A is selected from (a), (b), (c), (d) or (e), and wherein R^ is H or, C1-6-alkyl optionally substituted by CN or,C1-6-alkoxy or, aryl or, 5 or 6 membered heteroaryl or, sulfonylaryl or, -(CH2)m-R^ wherein R^ is C3-6-cycloalkyl, 5 or 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more substituents selected from the group consisting of: halo, CN, C]_6-alkyl, C1-6-alkoxy, C1-6-haloalkoxy, -C(0)0-C1-6-alkyl and phenyl optionally substituted by halo, C1-6-alkyl,C1-6-haloalkyl or C1-6-alkoxy, -(CH2)ni-NR'R" or, -(CH2)n-(C0)-R\ wherein R*' is aryl or 5 or 6 membered-heterocycloalkyl; R^ is one or more of H, halo, CN, nitro,C1-6-alkyl, C1-6-alkoxy, -0-CH2-C2-6-alkenyl, benzyloxy, or two R^ may form an oxo or dioxo bridge together with the indole ring to which they are attached; R'^ is H or, halo or, -(CO)-R^, wherein R^ is C1-6-alkyl, 5 or 6 membered heterocycloalkyl optionally substituted by C1-6-alkyl, or R"" is -(CH2)n-NR'R" or, C1-6-alkyl or aryl, which are optionally substituted by: -0(CO)-C1-6-alkyl, or by -NH(CO)R^, wherein R^ is C1-6-alkyl optionally substituted by halo or nitro, or R*^ is aryl or a 5 or 6 membered heteroaryl, which are optionally substituted by halo, nitro, C1-6_6-alkyl or C1-6-haloalkyl; R"^ is one or more of H, halo,C1-6-alkyl orC1-6-alkoxy or two R'^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ is H, C1-6-alkyl or aryl; R^^ isHorC1-6-alkyl; R^ is H or -SO2-R' wherein R^ is C]^-aIkyl or aryl; R' and R" are independently selected from H, C1-6_6-alkyl or -(CO)0-C]^-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. As it can be seen from the definition of A in the compounds of formula (I), said compounds of formula (I) encompass the compounds of formulae (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) and (I-h) as follows: wherein the dotted line is either nil or a double bond; R^ is H, or isC1-6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR'R", C3.6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(CO)-R^ wherein R^ is: C1-6-alkoxy, NR'R", 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R"^ is one or more of H, halo,C1-6-alkyl; R' is H, or is C1-6_6-alkyl, or is -(CO)-R^ wherein R*" is: C1-6-alkyl -(CH2)n-NR'R", R'* is is one or more of H, halo, or C1-6-alkoxy optionally substituted by OH, or two R"* may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R' is H; R^ is H; B is halo, CN, C1-6_6-alkyl optionally substituted by CN or C1-6-alkoxy,C1-6-alkoxy, C1-6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6-alkyl, -(CR"'R'")n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo,C1-6-alkoxy; R*and R" are H, C1-6-alkyl, C1-6-alkyl-NR'"R^\ -C(0)-C1-6-alkyl, -S(0)2-C1-6-alkyl or OH; R"' and R'" are H orC1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. Further, in a certain embodiment the compounds of the invention are those compounds of formula (I-a) as described above, wherein R' is H or, -(CH2)m-R^ wherein R^ is aryl which is optionally substituted by one or more substituents selected from the group consisting of: halo, CN, C1-6-alkyl, C1-6-alkoxy,C1-6-haloalkoxy, -C(0)0-C1-6_6-alkyl and phenyl optionally substituted by halo, C1-6-alkyl,C1-6-haloalkyl orC1-6-alkoxy; R^ is H or halo; R'^ is H or C1-6-alkyl; and R\ R^ and R*^ are H; m is 1 to 6; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: r-[(l-benzyl-2-methyl-lH-indol-3-yI)carbonyl]spiro[indene-l,4'-piperidine]; r-[(l*benzyl-2-methyl-lH-indol'3-yl)carbonyl]-2,3-dihydrospiro[indene-l,4'-piperidine]; l-[(l-benzyl-lH-indol-3-yl)carbonyl]spiro[indene-l,4'-piperidine]; r-[(2-methyl-lH-indol-3-yl)carbonyl]spiro[indene-l,4'-piperidine]; r-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[indene-l,4'-piperidine]; and r-[(6-chloro-lH-indol-3-yl)carbonyl]-2,3-dihydrospiro[indene-l,4-piperidine]. In a certain embodiment the compounds of the invention are those compounds of formula (I-b): R^ is H, or isC1-6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR\ CN, NR*R", C3-6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^ wherein R^ is:C1-6-alkoxy, NR'R", 5 or 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R'^ is one or more of H, halo, C1-6-aIkyl; R-"* is H, or is C1-6-alkyl, or is -(CO)-R^ wherein R"" is: C1-6-alkyl -(CH2)n'NR*R", R is is one or more of H, halo, or C1-6_6-alkoxy optionally substituted by OH, or two R"^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ is H; R"^ is H or -SO2-R' wherein R' is C1-6-alkyl or aryl; B is halo, CN, Q-6-alkyl optionally substituted by CN orC1-6-alkoxy,C1-6-alkoxy, C1-6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6.6-alkyl, -(CR'*R'^)n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo, C1-6-alkoxy; R*and R" are H, C1-6-alkyl,C1-6-alkyl-NR'"R'\ -C(0)-C1-6-alkyl, -S(0)2-C1-6-alkyl or OH; R"' and R*" are H or C1-6_6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. Further, in a certain embodiment the compounds of the invention are those compounds of formula (I-b) as described above, wherein R^ is H, or is -(CH2)m-R^ wherein R^ is aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more subsituents selected from the group consisting of: halo, CN, C1-6-alkyl, C1-6-alkoxy, C1-6-haloalkoxy, -C(0)0-C1-6.6-alkyl and phenyl optionally substituted by halo, C1-6-haloalkyl or C1-6-alkoxy, or is -(CH2)m-NR'R", or IS -(CH2)n-(C0)-R\ wherein R*" is aryl or 5 or 6 membered-heterocycloalkyl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R*' wherein R^ is NR'R", R^ is H or halo; R^^ isHorC1-6-alkyl; R"^ is H or halo; R^ is H; R is H or -S02-R^ wherein R^ is d^-alkyl or aryl; B is halo, NH2,C1-6-alkyl optionally substituted by CN orC1-6-alkoxy,C1-6-alkoxy, C1-6-haloalkoxy, C3.6-cycloalkyl, -C(0)0-C1-6-alkyl, -(CR"'R'')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo,C1-6-alkoxy; R', R" are independently selected from H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. In another embodiment thereof, R^ is H or, -(CH2)ni-R^ wherein R^ is aryl which is optionally substituted by one or more subsituents selected from the group consisting of: halo, CN, C1-6-alkyl, C1-6-alkoxy,C1-6-haloalkoxy, -C(0)0-C1-6-alkyl and phenyl optionally substituted by halo,C1-6-haloalkyl or C1-6-alkoxy; R^ is H or halo; R-^ isHorC1-6-alkyl; R'^ is H or halo; R^ is H; R^ is H or -SO2-R' wherein R' is C1-6_6-alkyl; m is 1 to 6; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-l-(methylsulfonyl)-l,2- dihydrospiro[indole-3,4'-piperidine]; l'-{[6-chloro-l-(3-fluorobenzoyI)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4' piperidine]; r-{[6-chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyI}-l,2-dihydrospiro[indole-3,4' piperidine]; l'-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyI}-l,2-dihydrospiro[indole- 3,4'-piperidine]; r-{[6-chloro-l-(2,3-difluorobenzoyl)-lH-indo]-3-yl]carbonyl}-l,2-dihydrospiro[indole- 3,4'-piperidme]; r-({6-chloro*l-[(3,5-difluorophenyl)sulfonyl]-lH-indol-3-yl}carbonyl)-l,2- dihydrospiro[indole-3,4'-piperidine]; 2-[6-chloro-3-(l,2-dihydro-lH-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yl]-l-(3,5-difluorophenyl)ethanone; 2-[6-chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yI]-l-(3,4-difluorophenyI)ethanone; 2-[6-chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yl]-l-(2-fluorophenyl)ethanone; 2-[6-chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indoM- yl]-N,N-diethylethanamine; and r-{[6-chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole- 3,4'-piperidine]. Preferred are the following compounds: l'-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine]; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine]; l'-{[6-chloro-l-(3,5-difluorobenzyI)-lH-indol-3-yl]carbonyl}-l,2-'dihydrospiro[indole- 3,4'-piperidine]; l'-{[6-chloro-l-(3-fluorobenzyI)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'- piperidine]; 2-[6-chloro-3-(l,2-dihydro-rH-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indoM- yl]-N,N-diethylacetamide; 2-[6-chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-l'-ylcarbonyI)-lH-indol-l- yl]-N,N-dimethylacetamide; 2-[6-chloro-3-(l,2-dihydro-lH-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yl]-l-pyridin-2-ylethanone; l'-{[6-chIoro-l-(pyridin-3-ylniethyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole- 3,4'-piperidine]; In a certain embodiment the compounds of the invention are those compounds of formula (I-c): R^ is H, or isC1-6-alkyl optionally substituted by CN, or is aryl, 5 or 6 membered heteroaryl or sulfonylaryl which are optionally substituted by one or more B, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR'R", C3-6-cycloalkyl, 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R*' wherein R^ is:C1-6-alkoxy, NR'R", 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or R^ and R^ together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by =0; R^ is one or more of H, halo, C1-6-alkyl optionally substituted by -NR'"R"', Cu6- alkoxy; R-^ is H, or is C1-6-alkyl, or is halo. or is -(CO)-R^ wherein R'^ is: C1-6-alkyl, -(CH2)„-NR'R", -(CH2)n-NR"'R'5 or 6 membered heterocycloalkyl optionally substituted by C1-6-alkyl; R"^ is one or more of H, halo, orC1-6-alkoxy optionally substituted by OH, or two R'* may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; B is halo, NH2,C1-6-alkyl optionally substituted by CN orC1-6-alkoxy, C1-6-alkoxy, C1-6-haloalkoxy, C.v6-cycloalkyl, -C(0)0-C1-6.6-alkyl, -(CR"'R'')n-phenyI, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo, C1-6-alkoxy; R'and R" areH,C1-6-alkyl, C]^-alkyl-NR'"R'\ -(C0)0-C1-6.6-alkyl, -C(0)-NR''R'\ -C(0)- C1-6-alkyl, -S(0)2-C1-6_6-alkyl, -S(0)2- NR"'R*^; R"' and R*' are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. In a further embodiment thereof, R^ is H or, C1-6.alkyl optionally substituted by CN or, -(CH2)m"R^ wherein R^ is aryl which is optionally substituted by one or more subsituents selected from the group consisting of: halo, CN, C1-6-alkyl, C1-6-alkoxy, C1-6-haloalkoxy, -C(0)0-C1-6.6-alkyl and phenyl optionally substituted by halo,C1-6-haloalkyl or C1-6-alkoxy; R^ is H or halo; R^is H,C1-6-alkylor, -(CO)-R*^, wherein R'^ is 5 or 6 membered heterocycloalkyl optionally substituted byC1-6-alkyl, or R^ is -(CH2)n-NR'R"; R** is H, halo, C1-6-alkoxy or two R"^ may form a dioxo bridge together with the phenyl ring to which they are attached; R' and R" are independently selected from H,C1-6-alkyl and -(C0)0-C1-6.6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]- 3-one; 4-{6-chloro-3-[(3"Oxo-l'H,3H-spiro[2-benzofuran-l,4-piperidin]-r-yl)carbonyl]-lH- indol-l-yl}butanenitrile; 2-{6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4-piperidin]-r-yl)carbonyl]-lH- indol-l-yl}propanenitrile; l'-({l-[2-(3,4-dimethoxyphenyl)ethyl]-5-methoxy-2-methyl-lH-indol-3-yl}carbony!)- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[l-(4-ethoxyphenyl)-5-methoxy-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4-piperidin]-3-one; 5-bromo-r-{[6-chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-{[6-chloro-l-(2,3-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-({6-chloro-l-[(3,5-difluorophenyl)sulfonyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; and r-[(l-biphenyl-3-yl-6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one. Preferred are the following compounds: r-[(6-chloro-lH-indol-3-yl)carbonyl]-6-methoxy-3H-spiro[2-benzofuran-l,4'-piperidin]- 3-one; 6-chloro-r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3- one; r-({6-chloro-2-[(4-methylpiperidin-l-yl)carbonyl]-lH-indol-3-yl}carbonyl)-5-fluoro- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 6-chloro-3-[(5-fluoro-3-oxo-lTI,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]- lH-indole-2-carboxamide; 6-chloro-N-[2-(dimethylamino)ethyl]-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran- l,4'-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxamide; r-{[6-chloro-2-(piperazin-l-ylcarbonyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-2-(morpholin-4-yIcarbonyI)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-2-[(4-methylpiperazin-l-yl)carbonyl]-lH-indol-3-yl}carbonyl)-5-fluoro- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-5-bromo-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; 5-bromo-r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3- one; l'-{[6-chloro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; l'-{[6-chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; r-{[6-chloro-l-(2,3-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; r-({6-chloro-l-[(3,5-difluorophenyl)sulfonyl]-lH-indol-3-yl}carbonyI)-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(2,3-difluorobenzoyI)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(3,5-difluorophenyl)sulfonyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-{[6-chloro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-[(l-biphenyl-2-yl-6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'- piperidin]-3-one; r-{[l-(biphenyl-3-ylcarbonyl)-6-chloro-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-[(l-{[4-amino-2-(inethoxymethyl)pyrimidin-5-yl]methyl}-6-chloro-lH-indol-3- yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({l-[(4-amino-2-methylpyrimidin-5-yl)methyl]-6-chloro-lH-indol-3-yl}carbonyl)-5- fluoro-3H-spiro[2-benzofuran-l,4'-piperidm]-3-one; l'-[(7-chloro-l-oxo-l,2,3,4-tetrahydropyrazino[l,2-a]indol-10-yl)carbonyl]-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(l,4-dibenzylpiperazin-2-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]- N-methyl-lH-indole-2-carboxainide; 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]- N-[2-(methylainino)ethyl]-lH-indole-2-carboxamide hydrochloride; 2-{6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indol-l-yl}-N-[2-(dimethylamino)ethyI]acetamide; and 2-{6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4-piperidin]-l'-yl)carbonyl]-lH- indol-l-yl}-N-[2-(dimethylamino)ethyl]acetamide. Particularly preferred are the following compounds: l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-chloro-3H-spiro[2-ben2ofuran-l,4'- piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-4-fluoro-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; l'-[(l-benzyl-2-niethyl-lH-indol-3-yl)carbonyl]-6-methoxy-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-5-methoxy-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-7-chloro-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-[(6-chloro-lH-indol-3-yl)carbonyI]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3- one; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]- N,N-dimethyl-lH-indole-2-carboxamide; tert-butyl {2-[({6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]- r-yl)carbonyl]-lH-indol-2-yl}carbonyl)amino]ethyl}methylcarbamate; 6-chloro-N,N-diethyl-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indole-2-carboxamide; r-{[6-chloro-2-(piperidin-l-ylcarbonyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- ben2ofuran-l,4'-piperidin]-3-one; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-7H-spiro[furo[3,4-f|[l,3]benzodioxole- 5,4'-piperidin]-7-one; 3-{6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]4H- indoM-yl}propanenitrile; {6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol- l-yl}acetonitrile; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-(2-hydroxyethoxy)-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]- 3-one; r-{[6-chloro-l-(3,5-difluorophenyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; r-{[6-chloro-l-(3,5-difluoroben2oyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; r-{[6-chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; r-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; r-({6-chloro4-[2-(3-fluoTophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[2-(2,5-difluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carboTiyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(3,5-difluorobenzyI)-lH-indol-3-yI]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4*-piperidin]-3-one; r-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[2-(3-fluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-{[6-chloro-l-(3,5-difluorobenzyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-({6-chloro-l-[2-(3-fluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4-piperidin]-3-one; r-({6-chloro-l-[2-(2-fluorophenyl)-2-oxoethyI]-lH-indoI-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[2-(3,4-difluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(3-fluorophenyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; r-{[6-chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(2-morpholin-4-yl-2-oxoethyl)-lH-indol-3-y]]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3"One; 2-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran4,4'-piperidin]-l'-yl)carbonyl]-lH- indol-l-yl}-N,N-dimethylacetamide; 2-{6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4-piperidin]-l'-yl)carbonyI]-lH- indol-l-yl}-N,N-diethylacetamide; r-{[6-chloro-l-(piperidin-l-y]carbonyl)-lH-indo]-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; tert-butyl {6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'"piperidin]-l'-yl)carbonyl]- lH-indol-l-yl}acetate; l'-[(6-chloro-l-pyridin-2-yl-lH-indol-3-yI)carbonyI]-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; r-[(6-chloro-l-pyridin-2-yl-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; l'-({6-chloro-l-[(2-methylpyridin-4-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(6-chloropyridin-3-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H- spiro[2-ben2ofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(3-chloro-6-methylpyridazin-4-yl)rnethyl]-lH-indol-3-yl}carbonyl)-5- fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(pyridin-4-ylmethyl)~lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(2-pyridin-4-ylethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(pyridiii-4-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; r-{[6-chloro-l-(2-oxo-2-pyridin-2-ylethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[2-(5-inethyl-2-phenyl-l,3-oxazol-4-yl)-2-oxoethyl]-lH-indol-3- yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4*-piperidin]-3-one; 2-{6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r- y l)carbonyl] - IH-indol-1 -y 1} -N,N-dimethy lacetamide; r-({6-chloro-l-[2-(dimethylaniino)ethyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(pyridin-3-ylmethyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidiTi]-3-one; r-{[6-chloro-l-(pyrazin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(pyrimidin-5-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; 3-{6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indol-l-yl}propanenitrile; tert-butyl {6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indol-l-yl}acetate; l'-{[6-chloro-l-(2-morpholin-4-yl-2-oxoethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({l-[(4-benzylmorpholin-2-yl)methyl]"6-chloro-lH-indoI-3-yI}carbonyI)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(5-methylisoxazol-3-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[2-(4-methylpiperazin-l-yl)-2-oxoethyl]-lH-indol-3-yl}carboTiyl)-5- fluoro-3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; r-({6-chloro-l-[(5-cyclopropyl-2-methyl-l,3-oxazol-4-yl)methyl]-lH-indo]-3- yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(l-methyl-lH-imidazol-5-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(3-methylisoxazol-5-yl)niethyl]-lH-indoI-3-yI}carbonyI)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(l,5-diinethyI-lH-pyra2ol-3-yl)methyl]-lH-indol-3-y]}carbonyl)-5- fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(3,5-dimethylisoxazol-4-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro- 3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(2,5-diniethyl-l,3-oxazol-4-yl)methyI]-lH-indol-3-yI}carbonyl)~5- fluoro*3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l-({6-chloro-l-[(3-fluorooxetan-3-yI)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(3-fluorooxetan-3-yl)methyl]-lH-indol-3-yl}carbonyl)"3H-spiro[2- benzofuran-l,4-piperidin]-3-one; l'-[(6-chloro-l-{[l-(methoxymethyl)-cyclopropyl]methyl}-lH-indoI-3-yl)carbonyl]-5- fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; [l-({6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indol-l-yl}methyl)cyclopropyl]acetonitrile; r-[(6-chloro-l-{[l-(methoxyinethyl)-cyclopropyl]methyl}-lH-indol-3-yl)carbonyl]-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; [l-({6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4-piperidin]-l'-yI)carbonyl]-lH- indol-l-yl}methyl)cyclopropyl]acetonitrile; l'-({6-chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yl}carbonyl)-5-fluoro- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one hydrochloride; r-({6-chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; tert-butyl 2-({6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yI)carbonyl]-lH-indol-l-yl}methyI)morpholine-4-carboxylate; tert-butyl 2-({6-chloro-3-[(3-oxo-lH,3H-spiro[2-benzofuran-l,4'-piperidin]-r- y])carbonyl]-lH-indol-l-yl}inethyl)morpholine-4-carboxylate; r-{[6-chloro-l-(morpholin-2-ylmethyI)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one dihydrochloride; r-{[6-chloro-l-(morpholin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one hydrochloride; 2-{6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'- yl)carbonyl]-lH-indol-l-yl}acetamide; 2-{6-chIoro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4-piperidin]-r- yl)carbonyl]-lH-indol-l-yl}-N-methylacetamide; r-{[6-chloro-l-(2-oxo-2-piperazin-l-ylethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; r-{[l-(3,5-difluorobenzyl)-lH-indoi-3-yl]carbonyl}-3H-spiro[2-ben2ofuran-l,4'- piperidin]-3-one; N,N-diethyl-2-{3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH- indol-l-yl}acetamide; and 2-{6-chloro-5-methyl-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indoM-yl}-N,N-dimethylacetamide. In a certain embodiment the compounds of the invention are those compounds of formula (I-d): wherein R^ is H, or isC1-6-alkyl optionally substituted by CN, or is aryl, 5 or 6 membered heteroaryl or sulfonylaryl which are optionally substituted by one or more B, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR*R", C3-6-cycloalkyl, 3 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^ wherein R^ is: C1-6-alkoxy, NR*R", 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or R and R together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by C(0)0-C1-6-alkyl or C1-6-alkyl; R is one or more of H, halo, C]^-alkyl, C1-6-alkoxy; R' is H, or isC1-6-alkyl, or is -(CO)-R^ wherein R' is C1-6-alkyl, or -(CH2)n-NR*R'; R"^ is one or more of H, halo, or C1-6_6-alkoxy optionally substituted by OH, or two R*^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R"^ is H or aryl; B is halo, NH2, C1-6-alkyl optionally substituted by CN orC1-6-alkoxy, C1-6-alkoxy, C1-6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6-alkyl, -(CR"'R*')n-pheny], wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo, Cj-6-alkoxy; R' and R" are H, C]^-alkyl, Ct^-alkyl-NR"'R', -(C0)0-C1-6_6-aIkyl, -C(0)-NR'"R'\ -C(0)-C1-6-alkyl, -S(0)2-C]^-alkyl, -S(0)2- NR"'R*" or OH; R"^ and R"' are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. In a further embodiment thereof, R^ is H or, C1-6-alkyl optionally substituted by CN or, -(CH2)m-R^ wherein R** is C3-6-cycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more substituents selected from the group consisting of: halo, CN, C1-6-alkyl,C1-6-alkoxy, -C(0)0-C1-6.6-alkyl and phenyl optionally substituted by halo, C1-6-alkyl C1-6-haloalky] or Cj^-alkoxy, -(CH2)m-NR'R" or, -(CH2)n-(C0)-R^ wherein R*" is aryl; R^ is H, halo or C1-6-alkoxy; R^ is H or, -(CO)-R^ wherein R' is C1-6-alkyl or, C1-6-alkyl; R"^ is H or halo; R"^ is H or aryl; R*andR"areC1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: l'-[(l-benzyl-2-methyMH-indol-3-yl)carbonyl]-3-phenyl-3H-spiro[2~benzofuran-l,4'- piperidine]; l'-[(l-ben2yl-5-methoxy-2-methyI-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidine]; r-[(l-{[2-(4-chlorophenyl)-l,3-thiazol-4-yl]methyl}-2-methyl-lH-indol-3-yl)carbonyl]- 3H-spiro[2-benzofuran-l,4-piperidine]; r-[(l-{[2-(4-chlorophenyl)-l,3-thiazol-4-yl]methyl}-2-methyl-lH-indol-3-yl)carbonyl]- 3H-spiro[2-benzofuran-l,4-piperidine]; r-{[2-methyl-l-({5-methyl-2-[3-(trifluoromethyl)phenyl]-l,3-oxazol-4-yl}methyl)-lH- indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-{[2-(2-fluorophenyl)-5-methyl-l,3-oxazol-4-yl]methyl}-2-methyl-lH-indol-3- yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4-piperidine]; r-[(l-{[2-(4-isopropylphenyl)-5-methyl-l,3-oxazol-4-yl]methyl}-2-methyMH-indol-3- yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-{[2-(4-ethylphenyI)-5-methyl-l,3-oxazol-4-yl]methyl}-2-methyl-lH-indol-3- yl)carbonyl]-3H-spiro[2-benzofuran-l,4-piperidine]; r-[(2-methyl-l-{[5-methyl-2-(2-methylphenyI)-l,3-oxazol-4-y]]methyl}-lH-indol-3- yl)carbonyl]-3H-spiro[2-benzofuran-l,4-piperidine]; r-{[2-methyl-l-({5-methyl-2-[4-(trifluoromethyl)phenyl]-l,3-oxazol-4-yl}methyl)-lH- indol-3-yI]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-{[2-methyl-l-({5-methyl-2-[2-(trifluoromethyI)phenyl]-l,3-oxazol-4-yl}methyl)-lH- indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(5-chloro-lH-indol-3-yl)carbonyI]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-methyl-lH-indol-3-yI)carbonyI]-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-(lH-indol-3-ylcarbonyI)-3H-spiro[2-benzofuran-l,4'-piperidine]; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yl]propanenitrile; 3-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- vlloroDanenitrile: 4-[6-chloro-3-(l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yljbutanenitrile; r-({6-chloro-l-[(3,5-difluorpphenyl)sulfonyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; r-{[l-(biphenyI-3-ylcarbonyI)-6-chloro-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine]; r-[(l-biphenyl-2-yl-6-chloro-lH-indo]-3-y])carbony]]-3H-spiro[2-benzofuran-l,4'- piperidine]; r-[(l-biphenyl-2-yl-6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidine]; r-({6-chIoro-l-[(l,4-dibenzyIpiperazin-2-yl)methyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4-piperidine]; tert-butyl 10-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-3,4- dihydropyrazino[l,2-a]indoIe-2(lH)-carboxylate; and r-({l-[3,5-bis(trifluoromethyl)benzyl]-6-chloro-2-methyl-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine]. The following compounds are preferred examples according to the invention: r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-[(l-benzyl-2-methyI-lH-indol-3-yl)carbonyl]-6-chloro-3H-spiro[2-benzofuran-l,4'- piperidine]; r-[(2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-benzoyl-2-methyI-lH-indol-3-yI)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidine]; r-{[2-methy]-l-(phenylsulfonyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4- piperidine]; l'-{[l-(cyclohexylmethyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; l'-{[l-(3-fluorobenzyI)-2-methyl-lH-indol-3-yl]carbonyI}-3H-spiro[2-benzofuran-l,4'- piperidine]; r'({2-methyl-l-[2-(trifluoromethoxy)benzyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzof uran-1,4'-piperidine]; r-{[l-(3,5-dimethylbenzyl)-2-methyMH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- 1,4-piperidine]; methyl 4-{[2-methyl-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH- indol-l-yl]methyl}benzoate; 4-{[2-methyl-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yl]methyI}benzonitrile; r-{[l-(3,5-difluorobenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; l'-{[l-(2-chIorobenzyI)-2'methyI-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidine]; r-{[l"(2-methoxybenzyl)-2-inethyl-lH-indo]-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; l'-{[l-(4-methoxybenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; l'-[(l-{[2-(2-methoxyphenyl)-5-methyI-l,3-oxazol-4-yI]methyI}-2-methyl-lH-indol-3- yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-benzyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(6-chloro-lH-indoI-3-yI)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; N,N-dimethyl-2-[3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol- l-yl]ethanamine; 2-rnethyl-l-[3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-2- yl]butan-l-one; [6-chloro-3-(rH,3H-spiro[2*benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yljacetonitrile; r-{[6-chloro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidine]; l'-{[6-chloro-l-(2-fluorobenzoyI)-lH-indol-3-yI]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidine]; l'-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; l'-{[6-chloro-l-(2,3-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; r-{[6-chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yI]carbonyI}-3H-spiro[2-benzofuran- l,4'-piperidine]; r-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'- piperidine]; r-{[6-chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(2-morpholin-4-yl-2-oxoethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- ben2ofuran-l,4'-piperidine]; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-y]]- N,N-dimethylacetamide; 2-[6-chloro-3-(l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-r~ylcarbonyl)-lH-indol-l-yl]- N,N-diethyIacetamide; r-{[6-chloro-l-(piperidin-l-ylcarbonyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- ben2ofuran-l,4'-piperidine]; tert-butyl [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yIcarbonyl)-lH- indol-l-yl]acetate; r-{[6-chloro-l-(3,5-difluorophenyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; r-{[6-chloro-l-(3-fluorophenyI)-lH-indol-3-yl]carboTiyl}-3H-spiro[2-benzofuran-l,4'- piperidine]; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4-piperidin]-r-ylcarbonyI)-lH-indol-l-yl]- l-(2-fluorophenyl)ethanone; r-[(6-chloro-l-pyridin-2-yl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidine]; r-{[6-chloro-l-(pyridin-4-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]- l-pyridin-2-ylethanone; l'-{[6-chloro-l-(pyridin-3-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidiiie]; l'-{[6-chloro-l-(pyridin"2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; l'-{[6-chIoro-l-(pyrazin-2-yImethyl)-lH-indol-3-yl]carbonyI}-3H-spiro[2-benzofuran- l,4'-piperidine]; r-{[6-chloro-l-(pyrimidin-5-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indoI-l-yl]- N,N-dimethylethanamine; r-{[6-chloro-l-(2-oxo-2-piperazin-l-ylethy])-lH-indol-3-yl]carbony]}-3H-spiro[2- benzofuran-l54'-piperidine]; r-({l-[(4-benzylmorpholin-2-yl)methyl]-6-chloro-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; r-({6-chloTO-l-[(5-methyIisoxazol-3-yl)inethyl]-lH-indoI-3-yI}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; r-({6-chloro-l-[2-(4-methylpiperazin-l-yl)-2-oxoethyl]-lH~indol-3-yI}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine]; 4-(l-{l-[(2-cyclopropyl-4-niethyrcyclopenta-l,4-dien-l-yl)methyl]-6-methyl-lH-inden- 3-yl}vinyl)-2',3'-dihydrospiro[cyclohexane-l,r-indene]; r-({6-chloro-l-[(l-methyl-lH-imidazol-5-yl)methyl]-lH-indol-3-yI}carbonyl)-3H- spiro[2-beTizofuran-l,4'-piperidine]; r-({6-chloro-l-[(3-methyIisoxazol-5-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; lH{6-chloro4-[(l,5-dimethyl-lH-pyrazol-3-yl)methyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(3,5-dimethylisoxazol-4-yI)methyl]-lH-indoI-3-yI}carbonyI)-3H- spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(2,5-diinethyl-l,3-oxazo]-4-yl)inethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(3-fluorooxetan-3-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; r-[(6-chloro-l-{[l-(niethoxymethyl)-cyclopropyl]methyl}-lH-indol-3-yl)carbonyl]-3H- spiro[2-benzofuran-l,4'-piperidine]; (l-{[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yl]methyl}cyclopropyl)acetonitrile; r-({6-chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine]; tert-butyl2-{[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l-ylcarbonyl)-lH- indol-l-yl]methyl}inorpholine-4-carboxylate; r-{[6-chloro-l-(niorpholin-2-ylmethyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] hydrochloride; 2-[6-chloro-3-(l'H3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-y]]- N-[2-(dimethyIaniino)ethyl]acetamide; 2-[6-chloro-5-methyl-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH- indol-l-yl]-N,N-dimethylacetamide; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuraTi-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yl]acetamide; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]- N-[2-(methylamino)ethyl]acetamide; N-(2-aminoethyI)-2-[6-chIoro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'- ylcarbonyl)-lH-indol-l-yl]acetamide; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yljethanamine; 2-[6-chloro-3"(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]- N-methylethanamine; 2-[6-chloro-3-(lH3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]- N-methylacetamide; r-{[6-chloro-l-(2-morpholin-4-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzof uran-1,4'-piperidine]; l'-{[6-chloro-l-(3-morpholin-4-ylpropyl)-lH-indol-3-yl]carboTiyl}-3H-spiro[2- benzofuran-l,4-piperidine]; r-{[6-chloro-l-(oxiran-2-ylmethyl)-lH-indoI-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yl]ethanol; r-({6-chloro4-[(2-inethylpyridin-4-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(3S)-piperidin-3-ylmethyI]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzof uran-1,4'-piperidine]; 2-[6-chloro-3-(rH,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]- N-hydroxyethanamine; l'-{[6-chloro-l-(tetrahydro-2H-pyran-4-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(l-inethylpyrroIidin-3-yl)methyI]-lH-indoI-3-yI}carbonyl)-3H-spiro[2- benzof uran-1,4'-piperidine]; l'-[(6-chloro-l-{[(3S)-l-methylpiperidin-3-yl]methyl}-lH-indol-3-yl)carbonyl]-3H- spiro[2-benzofuran-1,4'-piperidine]; l'-{[6-chloro-l-(pyrrolidin-3-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine]; r-({6-chloro-l-[(2S)-pyrrolidin-2-ylmethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; l'-[(6-chloro-2-inethyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-(l,2,3,4-tetrahydropyrazino[l,2-a]indol-10-ylcarbonyl)-3H-spiro[2-benzofuran-l,4'- piperidine] hydrochloride; l'-[(2-methyl-l,2,3,4-tetrahydropyrazino[l,2-a]indol-10-yl)carbonyl]-3H-spiro[2- benzofuran-l,4'-piperidine]; l'-[(6-chloro-2-inethyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; N-{2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yl]ethyl}acetamide; N-{2-[6-chloro-3-(l'H,3H-spiro[2-beiizofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yl]ethyl}methanesulfonainide; N-{2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l- yl]ethyl}-N-methylacetamide; N-{2-[6-chloro-3-(rH,3H-spiro[2-ben2ofuran-l,4*-piperidin]-r-ylcarbonyl)-lH-indol-l- yI]ethyl}-N-methylmethanesulfonamide; r-[(6-chloro-l-{[(2S)-l-methylpyrrolidin-2-yl]methyl}-lH-indol-3-yl)carbonyl]-3H- spiro[2-ben2ofuran-l,4'-piperidine]; and r-[(6-chloro-l-{[(2R)-l-methylpyrrolidin-2-yl]methyl}-lH-indol-3-yl)carbonyl]-3H- spiro[2-benzofuran-l,4'-piperidine]. In a certain embodiment the compounds of the invention are those compounds of formula (I-e): wherein R^ is H, or is C1-6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR'R", C3-6-cycloalkyI, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^ wherein R^ is:C1-6-alkoxy, NR'R", 5 or 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R^ is one or more of H, halo, C1-6-alkyl; R^ is H, or isC1-6-alkyl, or is -(CO)-R^ wherein R"" is: C1-6-alkyl .(CH2)n-NR'R", R*^ is is one or more of H, halo, or C1-6-alkoxy optionally substituted by OH, or two R'* may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ is H; B is halo, CN, C1-6-alkyl optionally substituted by CN orC1-6-alkoxy, C1-6-alkoxy,C1-6-haloalkoxy, C3.6-cycloalkyl, -C(0)0-C1-6.6-alkyl, -(CR"'R*')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo,C1-6-alkoxy; R' and R" are H, C1-6_6-alkyl,C1-6-alkyl-NR"*R'\ -C(0)-C1-6-alkyl, -S(0)2-C1-6-alkyl or OH; R"' and R'^ are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. Further, in a certain embodiment the compounds of the invention are those compounds of formula (I-e), wherein R^ is H or, -(CH2)ni-R^ wherein R^ is 5 or 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl or, -(CH2)m-NR'R" or, -(CH2)n-(C0)-R\ wherein R*' is 5 or 6 membered-heterocycloalkyl; R is one or more of H or halo; R^ is H, or isC1-6-alkyl; R** is one or more of H or halo; R*^ is H; R' and R" are Q^-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: r-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine]; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine]; r-(lH-indol-3-yIcarbonyl)spiro[l-benzofuran-3,4'-piperidine]; l'-[(6-chloro-5-fluoro-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine]; 2-[6-chloro-3-(rH-spiro[l-benzofuran-3,4'-piperidin]-r-ylcarbonyl)-lH-indoI-l-yl]-N,N-dimethylethanamine; r-{[6-chloro-l-(2-pyrrolidin-l-ylethyl)-lH-indol-3-yl]carbonyl}spiro[l-benzofuran-3,4'-piperidine]; 3-[6-chloro-3-(rH-spiro[l-benzofuran-3,4*-piperidin]"r-ylcarbonyl)-lH-indol-l-yl]-N,N-dimethylpropan-1 -amine; l'-{[6-chloro-l-(2-morpholin-4-ylethyl)-lH-indol-3-yl]carbonyl}spiro[l-benzofuran-3,4'-piperidine]; 2-[6-chloro-3-(rH-spiro[l-benzofuran-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N,N-diethylethanamine; l'-({6-chloro-l-[2-(lH-pyrrol-l-yl)ethyl]-lH-indol-3-yl}carbonyl)spiro[l-benzofuran-3,4'-piperidine]; and r-{[6-chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indol-3-yl]carbonyl}spiro[l* benzofuran-3,4'-piperidine]. In a certain embodiment the compounds of the invention are those compounds of formula (I-f): wherein R^ is H, or is C1-6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)ni-R^ wherein R^ is: OR*, CN, NR'R", C3-6-cycloalkyI, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^ wherein R^ is: C1-6-e-alkoxy, NR'R", 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R" is one or more of H, halo,C1-6-alkyl; R^ is H, or is C1-6-alkyl, or is -(CO)-R^ wherein R"^ is: C1-6_6-alkyl -(CH2)n-NR'R", R"* is is one or more of H, halo, or C]_6-alkoxy optionally substituted by OH, or two R"^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; B is halo, CN, C1-6-alkyl optionally substituted by CN or C1-6-alkoxy, C1-6-alkoxy, C1-6.6-haloalkoxy, Cs-e-cycloalkyl, -C(0)0-C1-6.6-alkyl, -(CR"'R'')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo, C1-6-alkoxy; R'and R" are H, C1-6-alkyl, C1-6-alkyl-NR"'R'\ -C(0)-C1-6-alkyl, -S(0)2-CM,-alkyl or OH; R'" and R*^ are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. Further, in a certain embodiment the compounds of the invention are those compounds of formula (I-f), wherein R^ is H; R^ is one or more of H or halo; R^ is H; R"* is one or more of H or halo; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: 5Tbromo-l'-(lH-indol-3-ylcarbonyl)spiro[indole-3,4'-piperidin]-2(lH)-one; and 5-bromo-r-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[indole-3,4'"piperidin]-2(lH)-one. In a certain embodiment the compounds of the invention are those compounds of formula (I-g): wherein R^ is H, or is C1-6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR', NR'R", C3-6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R\ wherein R*" is:C1-6-alkoxy, NR'R", 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R^ is one or more of H, halo, C1-6-alkyl; R'"* is H, or isC1-6-alkyl, or is -(CO)-R^ wherein R"" is: C1-6_6-alkyl -(CH2)n-NR'R', R'* is is one or more of H, halo, or C1-6-alkoxy optionally substituted by OH, or two R"* may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; B is halo, CN, C1-6-alkyl optionally substituted by CN or C1-6-alkoxy, C1-6-alkoxy, C]^-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6-alkyl, -(CR"'R'')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo, C1-6-alkoxy; R' and R" are H, C1-6-alkyl, C1-6_6-alkyl-NR'"R*\ -C(0)-C1-6-alkyl, -S(0)2-C1-6-alkyl or OH; R"' and R'" are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. Further, in a certain embodiment the compounds of the invention are those compounds of formula (I-g), wherein R^ is H or, -(CH2)m-R^ wherein R^ is aryl; R^ is one or more of H or halo; R^ is H, oris C1-6-alkyl; R^ is H; R^ is H; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: (SS,RR)-r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; (RS,SR)-r-[(6-chloro-lH-indoI-3-yI)carbonyl]-3',5'-dimethyl-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one; (RS,SR)-r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; and (lr,3'R,5'S)4'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one. In a certain embodiment the compounds of the invention are those compounds of formula (I-h): wherein R^ is H, or is C1-6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR'R", C3-6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^ wherein R*" is: C1-6-alkoxy, NR'R", 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R is one or more of H, halo,C1-6-alkyl; R"^ is H, orisC1-6-alkyl, or is -(CO)-R^ wherein R"" is: C1-6-alkyl -(CH2)n-NR'R", R" is is one or more of H, halo, or C1-6-alkoxy optionally substituted by OH, or two R"^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R** is H or C1-6-alkyl; X is CH2 or C=0; B is halo, CN, C1-6-alkyl optionally substituted by CN or C1-6-alkoxy, C1-6-alkoxy, C1-6-haloalkoxy, C3-6-cycloalkyl, -C(0)0-C1-6.6-alkyl, -(CR"'R*')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C1-6-alkyl optionally substituted by CN or halo, C1-6-alkoxy; R* and R" are H, C1-6-alkyl,C1-6-alkyl-NR"'R'\ -C(0)-C1-6-alkyI, -S(0)2-C1-6_6-alkyl or OH; R"' and R*' are H or C1-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. Further, in a certain embodiment the compounds of the invention are those compounds of formula (I-h), wherein R^ is H, or is -(CH2)n-(CO)-R^ wherein R^ is NR*R"; R is one or more of H or halo; R'^ is H; R^ is H; R** isHorC1-6-alkyI; X is CH2 or C=0; R' and R" are H or C1-6 .6-alkyl; as well as pharmaceutically acceptable salts thereof. The following compounds are examples according to the invention: l'-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[isoindole-l,4'-piperidin]-3(2H)-one; r-[(6-chloro-lH-indol-3-yl)carbonyl]-2-methyl-2,3-dihydrospiro[isoindole-l,4'-piperidine]; l'-[(6-chloro-lH-indol-3-yl)carbonyl]-2,3-dihydrospiro[isoindole-l,4'-piperidine]; and 2-{6-chloro-3-[(3-oxo-2,3-dihydrO"l'H-spiro[isoindole-l,4'-piperidin]-r-yl)carbonyI]-lH-indol-l-yl}-N-methylacetamide. The invention also encompasses the compounds of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f)j (I-g) or (I-h) for a use in the prevention or treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver C1-6rrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders. The invention also encompasses a pharmaceutical composition comprising a compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h), which pharmaceutical composition is useful against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver C1-6rrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders. The invention further encompasses the use of a compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h) for the preparation of a medicament w^hich is useful against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver C1-6rrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders. In a certain embodiment, the compounds of the invention can be manufactured according to a process comprising the step of reacting a compound of formula (II): with a compound of formula A-H in order to obtain the compound of formula (I), wherein A, R\ R^ and R^ are as defined hereinabove. In another embodiment, the compounds of the invention can be manufactured according to a process comprising the step of reacting a compound of formula (III): are either commerC1-6ally available or readily prepared using a procedure described in JMed.Chem, 1991, 34,140. Alternatively, they can be prepared following the general scheme D as described hereinafter. The spiropiperidine derivatives A-H are either commerC1-6ally available or can be prepared using commerC1-6ally available starting materials and conventional methods. Spiropiperidines A-H of group (h) can be prepared as described in general scheme E. General scheme A is hereinafter further illustrated with general scheme and procedure I to which, e.g., examples 1 to 24, 34, 39-43, 66-70, 77-80 and 123-126 refer. Compounds of formula (I) with R' different from H can be prepared by N-deprotonation of an indole derivative (III) (a compound of formula (I) wherein R^ is H) followed by treatment with an electrophilic reactant R^-Y (wherein Y is a leaving group) which is either commerC1-6ally available or easily prepared according to methods well known in the art and commerC1-6ally available starting materials. Alternatively, compounds (I) can be prepared by coupling of an indole derivative (III) with a boronic aC1-6d R^-B(0H)2 using a transition metal catalyst such as Cu(0Ac)2 in the presence of pyridine, molecular sieves and air in dichloromethane. Derivatives (III) are prepared using the method described in the general scheme A. General scheme B is hereinafter further illustrated with general schemes and procedures II and III to which, e.g., examples 46 to 65, 81 to 87, 93-103,133-136, 142-144, 150-154, 161-168,170, 172-175, 180,182,183, 188-193,195-197, 201-203, 220, 224, 228-247, 253-260, 263, 266, and 267 refer, as well as general schemes and procedures V (e.g. examples 104-115, 117, 204-212), VI (e.g. examples 155-157, 222, 223, 225, 226), VII (e.g. examples 88-92, 128-132,137-141,145-149, 158, 214-218, 221) and VIII. General scheme C General scheme C Compounds of formula (I) wherein R"^ is an amide (-CONR'R") can be prepared via an amide coupling between an indole 2-carboxylic aC1-6d (IV) and an amine NHR'R". The indole 2-carboxylic aC1-6d derivatives (IV) are readily prepared using commerC1-6ally available starting products and conventional methods. General scheme C is hereinafter further illustrated with general scheme and procedure IV to which, e.g., examples 24 to 33 refer. General schenieD General scheme D The treatment of an indole derivative (Va) with trifluoroacetic anhydride in DMF affords intermediate (VI) which can be hydrolysed with an aqueous sodium hydroxide solution to give the 3-carboxylic aC1-6d indole derivative (Ila). Alternatively, (VI) can react with an electrophilic reactant R'-Y to give (VII), which is then converted to the corresponding carboxylic aC1-6d derivative (lib) with NaH/H20 in DMF (see/. Org Chem., 1993, 10, 2862). Intermediate (VII) can alternatively be obtained by treatment of an indole derivative (Vb) with trifluoroacetic anhydride in DMF, dichloromethane or 1,2-dichloroethane. Addition of a suitable base may be advantageous. Cyclization of a bromophenylacetonitrile derivative (VIII) affords a 4-bromoaryl-2-cyanopiperidine derivative (IX), The cyano group is transformed to an azidocarbonyl group using standard functional group transformations to give a compound of formula (X). Upon heating in toluene an azide (X) undergoes a Curtius rearrangement. The crude intermediate isocyanate is trapped to form a lactam of formula (XI) after bromine-lithium exchange using tert-butyllithium at -100 'C. N-Deprotection affords spiropiperidine (XII). Alternatively, lactam (XI) can be N-alkylated to give lactam (XV). Both, lactam (XI) and (XV), are reduced using standard conditions to afford spiropiperidines (XIV) and (XVI) after N-deprotection, respectively. The following general procedures I to VIII are meant to give examples of the preparation of the compounds of the invention according to general schemes A to C. The following general procedure I is an example of the preparation of the compounds of the invention according to general scheme A. Goieral procedure I General procedure I - amide coupling: To a stirred solution of an indole-3-carboxylic aC1-6d derivative (1 mmol) in 10 ml CH2C1-62 was added (1.3 mmol) EDC, (1.3 mmol) HOBt, (1.3 mmol) EtsN and (1 mmol) of the amine derivative. The mixture was stirred overnight at RT and then poured onto water and extracted with CH2C1-62. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography or preparative HPLC afforded the title compound. The following general procedures II and III are examples of the preparation of the compounds of the invention according to general scheme B: General procedure 11: To a stirred solution of 30 mg (0.09 mmol) of r-[(2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (the preparation of which have been described in example 43) in 3 ml DMF was added 4 mg (0.10 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then the electrophilic reactant R^-Y (0.15 mmol) was added. The mixture was stirred an additional 18 hours and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Purification by preparative HPLC afforded the corresponding derivatives. General procedure III: To a stirred solution of 20 mg (0.054 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine] (the preparation of which have been described in example 77) in 3 ml DMF was added 8.8 mg (0.11 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min, and then the electrophilic reactant R^-Y (0.08 mmol) was added. The mixture was stirred an additional 18 hours at 60°C and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Purification by preparative HPLC afforded the corresponding derivatives. The following general procedure IV is an example of preparation of the compounds of the invention according to general scheme C: General procedure IV: To a stirred solution of 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (1 mmol) (the preparation of which have been described in example 24d) in 10 ml CH2C1-62 was added (1.3 mmol) EDC, (1.3 mmol) HOBt, (1.3 mmol) EIBN and (1 mmol) of the amine derivative (wherein R' and R" are as defined hereinabove). The mixture was stirred overnight at RT and then poured onto water and extracted with CH2C1-62. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography or preparative HPLC afforded the title compound. The following general procedures V to VIII are examples of the preparation of the compounds of the invention according to general scheme B: General procedure V: To a stirred solution of an indole derivative (III) (0.079 mmol) in 2 ml DMF was added NaH (0.10 mmol, 60% in oil). The mixture was stirred at room temperature for 30 min. and then the electrophile R^-Y (0.15 mmol) was added. The mixture was stirred for an additional 18 hours and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Purification by preparative HPLC afforded the corresponding derivatives. General procedure VI - aryl coupling: To a solution of the indole in dichloromethane was added anhydrous Cu(0Ac)2 (2 eq), the boronic aC1-6d (3 eq) and pyridine (4 eq), and the reaction mixture stirred 16h at room temperature in the presence of 0.4 nm molecular sieve under an open to air atmosphere. Filtration through decalite, washing with dichloromethane and concentration gave the crude product which was purified by silica gel chromatography (hexane/ethyl acetate) to give the desired product. General prcxBduresVI I and VI11 General procedure VII - acylation: A solution of the indole in dry DMF was treated with sodium hydride (1.05 eq) and stirred for 15 min at room temperature, then treated with an aC1-6d chloride (1.1 eq) and stirred at room temperature for 2h. Purification by preparative HPLC yielded the desired product. General Procedure VIII - sulphonylation: A solution of the indole in dry DMF was treated with sodium hydride (1.05 eq) and stirred for 15 minat room temperature, then treated with a sulphonyl chloride (1.1 eq) and stirred at room temperature for 2h. Purification by preparative HPLC yielded the desired product. Results - Via activity Material & Method: The human Via receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequenC1-6ng to confirm the identity of the amplified sequence. To demonstrate the affinity of the compounds from the present invention to the human Via receptor binding studies were performed. Cell membranes were prepared from HEK293 cells transiently transfected with the expression vector and grown in 20 liter fermenters with the following protocol. 50g of cells are resuspended in 30ml freshly prepared ice cold Lysis buffer (50mM HEPES, ImM EDTA, lOmM MgC12 adjusted to pH= 7.4 + complete cocktail of protease inhibitor (Roche Diagnostics)). Homogenized with Polytron for Imin and sonicated on ice for 2x 2 minutes at 80% intensity (Vibracell sonicator). The preparation is centrifuged 20 min at 500 g at 4°C, the pellet is discarded and the supernatant centrifuged Ihour at 43'OOOg at 4°C (19'000rpm). The pellet is resuspended in 12.5 ml Lysis buffer+12.5ml Sucrose 20% and homogenized using a Polytron for 1-2 min. The protein concentration is determined by the Bradford method and aliquots are stored at -80°C until use. For binding studies 60mg Yttrium silicate SPA beads (Amersham) are mixed with an aliquot of membrane in binding buffer (50 mM Tris, 120mM NaCl, 5 mM KCl, 2 mM CaC12, 10 mM MgC12) for 15 minutes with mixing. 50ul of bead/membrane mixture is then added to each well of a 96 well plate, followed by 50ul of 4 nM 3H-Vasopressin (American Radiolabeled Chemicals). For total binding measurement lOOul of binding buffer are added to the respective wells, for non-speC1-6fic binding lOOul of 8.4mM cold vasopressin and for compound testing lOOul of a serial dilution of each compound in 2%DMS0. The plate is incubated Ih at room temperature, centrifuged 1 min at lOOOg and counted on a Packard Top-Count. Non-speC1-6fic binding counts are subtracted from each well and data is normalized to the maximum speC1-6fic binding set at 100%. To calculate an IC 50 the curve is fitted using a non-linear regression model (XLfit) and the Ki is calculated using the Cheng-Prussoff equation. The compounds of formula (I) as well as their pharmaceutically usable aC1-6d addition salts can be used as medicaments, e.g. in the form of pharmaceutical preparations. The pharmaceutical preparations can be administered orally, e.g. in the form of tablets, coated tablets, dragees, hard and soft gelatine capsules, solutions, emulsions or suspensions. The administration can, however, also be effected rectally, e.g. in the form of suppositories, or parenterally, e.g. in the form of injection solutions. The compounds of formula (I) and their pharmaceutically usable aC1-6d addition salts can be processed with pharmaceutically inert, inorganic or organic exC1-6pients for the production of tablets, coated tablets, dragees and hard gelatine capsules. Lactose, corn starch or derivatives thereof, talc, stearic aC1-6d or its salts etc can be used as such exC1-6pients e.g. for tablets, dragees and hard gelatine capsules. Suitable exC1-6pients for soft gelatine capsules are e.g. vegetable oils, waxes, fats, semi-solid and liquid polyols etc. Suitable exC1-6pients for the manufacture of solutions and syrups are e.g. water, polyols, saccharose, invert sugar, glucose etc. Suitable exC1-6pients for injection solutions are e.g. water, alcohols, polyols, glycerol, vegetable oils etc. Suitable exC1-6pients for suppositories are e.g. natural or hardened oils, waxes, fats, semi-liquid or liquid polyols etc. Moreover, the pharmaceutical preparations can contain preservatives, solubilizers, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances. The dosage can vary within wide limits and will, of course, be fitted to the individual requirements in each particular case. In general, in the case of oral administration a daily dosage of about 10 to 1000 mg per person of a compound of general formula (I) should be appropriate, although the above upper limit can also be exceeded when necessary. The following Examples illustrate the present invention without limiting it. All temperatures are given in degrees Celsius. Example A Tablets of the following composition are manufactured in the usual manner: mg/tablet Active substance 5 Lactose 45 Corn starch 15 Microcrystalline cellulose 34 Magnesium stearate 1 Tablet weight 100 Example B Capsules of the following composition are manufactured: mg/capsule Active substance 10 Lactose 155 Com starch 30 Talc 5 Capsule fill weight 200 The active substance, lactose and corn starch are firstly mixed in a mixer and then in a comminuting machine. The mixture is returned to the mixer, the talc is added thereto and mixed thoroughly. The mixture is filled by machine into hard gelatine capsules. Example C Suppositories of the following composition are manufactured: mg/supp. Active substance 15 Suppository mass 1285 Total 1300 The suppository mass is melted in a glass or steel vessel, mixed thoroughly and cooled to 45°C. Thereupon, the finely powdered active substance is added thereto and stirred until it has dispersed completely. The mixture is poured into suppository moulds of suitable size, left to cool; the suppositories are then removed from the moulds and packed individually in wax paper or metal foil. EXAMPLES Examples of compounds of formula fl-a) Example 1 l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]spiro[indene-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[indene-l,4'-piperidine] prepared as described in J. Med. Chem, 1992, 35, 2033, - AC1-6d: l-Benzyl-2-methyMH-indole-3-carboxylic aC1-6d (the preparation of which is described hereinafter), ES-MS m/e (%): 433.5 (M+H^. l-Benzvl"2-methvl-lH-indole-3-carboxvlic aC1-6d To a stirred solution of 0.50 g (3.10 mmol) 2-methyl-lH-indole-3-carboxylic aC1-6d (described in J.Heterocyclic Chem, 1917, 14, 1123) in 5 ml DMF was added 0.27 g (6.75 mmol) of NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 0.39 ml (3.28 mmol) of benzyl bromid was added. The mixture was stirred an additional hour and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Crystallization in Et20 afforded 1-Benzyl-2-methyl-lH-indole-3-carboxylie aC1-6d. Example 2 l'-[(l-benzyl-2-methyl-lH-indol-3-yI)carbonyl]-2,3-dihydrospiro[indene-l,4'- Amide coupling according to general procedure I described hereinabove: - Amine: 2,3-dihydrospiro[indene-l,4'-piperidine] prepared as described in 7. Med. Chem, 1992, 35, 2033, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 435.5 (M+H^). Example 3 l'-[(l-benzyl-lH-indol-3-yl)carbonyl]spiro[indene-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[indene-l,4'-piperidine] prepared as described in/. Med. Chem. 1992, 35, 2033, - AC1-6d: l-benzyl-lH-indole-3-carboxylic aC1-6d (the preparation of which is described hereinafter), ES-MS m/e (%): 419.4 (M+H^). l-benzyl-lH-indole-3-carboxvlic aC1-6d To a stirred solution of 0.50 g (3.10 mmol) lH-indole-3-carboxylic aC1-6d in 5 ml DMF was added 0.27 g (6.75 mmol) of NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 0.39 ml (3.28 mmol) of benzyl bromid was added. The mixture was stirred an additional hour and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Crystallization in Et20 afforded 0.61 g (78%) of l-benzyl-lH-indole-3-carboxylic aC1-6d as a white solid. ES-MS m/e (%): 250 (M-H^). Amide coupling according to general procedure I described hereinabove: - Amine: spiro[indene-l,4'-piperidine] prepared as described in J.MedChem. 1992, 35, 2033, - AC1-6d: 2-Methyl-lH-indole-3-carboxylic aC1-6d prepared as described 'm J.Heterocyclic Chem. 1977,14,1123, ES-MS m/e (%): 343.2. (M+H^- Example 5 l'-[(6-chIoro-lH-indol-3-yl)carbonyl]spiro[indene-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove; - Amine: spiro[indene-l,4'-piperidine] prepared as described in J.Med.Chem, 1992, 35, 2033, - AC1-6d: 6-chloro-lH-indole-3-carboxyIic aC1-6d (the preparation of which is described hereinafter), ES-MS m/e (%): 363.4 (M+H^). 6-chloro-lH-indole-3-carboxvlic aC1-6d Using a procedure described in/. Med, Chem, 1991, 34,140, from 7.0 g (0.046 mmol) of 6-chloro-lH-indole was prepared 5.80 g (64%) of 6-chloro-lH-indole-3-carboxylic aC1-6d as a light brown solid. ES-MS m/e (%): 194 (M^H^). Example 6 l'-[(6-chloro-lH-indoI-3-yl)carbonyl]-2,3-dihydrospiro[indene-l,4'-piperidine] Amide coupling according to g&neral procedure I described hereinabove: - Amine: 2,3-dihydrospiro[indene-l,4'-piperidine] prepared as described in J.Med.Chem. 1992, 35, 2033, - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 5), ES-MS m/e (%): 365.4 (M+H^). Examples of compounds of formula (1-b) Example 7 l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-l-(methylsulfonyl)-l,2- dihydrospiro[indole-3,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: l-(methylsulfonyl)-l,2-dihydrospiro[indole-3,4'-piperidine] prepared as described in Tetrahedron, 1997, 53, 10983, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 514.6 (M+H^. Example 8 r-[(6-chloro-lH-indol-3-yI)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: l,2-dihydrospiro[indole-3,4'-piperidine] prepared as described in Tetrahedron, 2004, 60, 4875-4878, - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 5), ES-MS m/e (%): 366.4 (M+H^). Example 9 l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-354'- piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: l,2-dihydrospiro[indole-3,4'-piperidine] prepared as described in Tetrahedron, 2004, 60, 4875-4878, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 436.6 (M+H"). Examples of compounds of formula (I-c) Example 10 l'-[(l-benzyl-2-methyl-lH-indol-3-yi)carbonyl]-6-chloro-3H-spiro[2-benzofuran- Amide coupling according to general procedure I described hereinabove: - Amine: 6-chloro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in European patent application EP722941, - AC1-6d: l-Ben2yl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 485.5 (M+H^). Example 11 l*-[(l-ben2yl-2-methyl-lH-indol-3-yl)carbonyl]-4-fluoro-3H-spiro[2-benzofuran- l,4*-piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: 4-fluoro-3H"Spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in EP722941, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 469.5 (M+H^). Example 12 l*-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-methoxy-3H-spiro[2-benzofuran- Amide coupling according to general procedure I described hereinabove: - Amine: 6-methoxy-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in EP722941, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 481.4 (M+H^. Example 13 l'-[(l-benzyI-2-methyl-lH-indol-3-yl)carbonyI]-5-methoxy-3H-spiro[2-benzofuran- l?4'-piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: 5-methoxy-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described inEP722941, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 481.6 (M+H^). Example 14 l'-[(l-benzyl-2-methyI-lH-indol-3-yl)carbonyI]-7-chIoro-3H-spiro[2-benzofuran- Amide coupling according to general procedure I described hereinabove: - Amine: 7-chloro-3H-spiro[2-benzofuran-U4'-piperidin]-3-one (the preparation of which is described hereinafter), - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 485.5 (M+H^). 7-chloro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure described in J.Org.Chem. 1976,41, 2628, from 2-bromo-3-chloro-benzoic aC1-6d (the preparation of which is described in J.Org.Chem. 203, 68, 2030) and l-benzyl-piperidin-4-one was prepared 7-chloro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one, after debenzylation (Pd/C, H2, MeOH/HCl), as a white solid. ES-MS m/e (%): 238.7 (M+H^). Example of compounds of formula (I-g) Example 15 (55^)-r-[(l-benzyl-2-methyl-lH-lndol-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: (SS,RR)-3',5'-dimethyl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in W09929696, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 479.6 (M+H^). Examples of compounds of formula (I-c) Example 16 l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in/. Org. Chem, 1976, 41, 2628, - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 5), ES-MS m/e (%): 381.4 (M+H^. Example 17 l'-[(6-chloro-lH-indol-3-yl)carbonyl]-6-methoxy-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: 6-methoxy-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in EP722941, - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 5), ES-MS m/e (%): 411.4 (M+H^. Example of compounds of formula (1-g) Example 18 (/?5^l?)-l-[(6-chloro-lH-indoI-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: (lr,3'R,5'S)-3',5'-dimethyl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in W09929696; - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 5), ES-MS m/e (%): 409.4 (M+H^. Examples of compounds of formula (I-c) Example 19 l'-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: 5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in WO2001014376, - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 5), ES-MS m/e (%): 399.4 (M+H^. Example 20 6-chloro-l'-[(6-chloro-lH-indoI-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: 6-chloro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in EP722941, - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 88), ES-MS m/e (%): 415.3 (M^). Example of compounds of formula (I-g) Example 21 (iJ5,SI?)-l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3',5'-diinethyl-3H-spiro[2" benzofuran-l,4'-piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine: (lr,3'R,5'S)-3',5'-dimethyl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in W09929696, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 479.6 (M+H^). Examples of compounds of formula (I-c) Example 22 l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one Amide coupling according to general procedure I described hereinabove: - Amine; 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in 7. Org, Chem. 1976, 41, 2628, - AC1-6d: l-Benzyl-2-methyMH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 451.6 (M+H^). Example 23 r-[(l-benzyI-2-methyl-lH-indol-3-yI)carbonyI]-5-fluoro-3H-spiro[2-benzofuran- 1,4' -piperidin] -3-one Amide coupling according to general procedure I described hereinabove: - Amine: 5-fluoro-3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one prepared as described in WO2001014376, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 469.6 (M+H^). Example 24 l'-({6-chloro-2-[(4-methylpiperidin-l-yl)carbonyl]-lH-indol-3-yl}carbonyl)-5- fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one a^ 6-Chloro-3-formvl-lH-indole-2-carboxvlic aC1-6d ethvl ester To a stirred solution of 2.36 g (0.011 mol) of 6-chloro-lH-indole-2-carboxylic aC1-6d ethyl ester in DMF (20 ml) was added phosphorus oxychloride (1.08 ml, 0.012 mol) at RT. The solution was heated at 60"C for 2 hours, then cooled to RT, and poured into water. The ph was adjusted to 7 by careful addition of aq. NaOH 2N. The resulting brown preC1-6pitate was collected by filtration and dried over night in a vacuum oven (50^C). The title compound was obtained as light brown solid, 2.05 g (77%). b) 6-Chloro-lH-indole-2,3-dicarboxvlic aC1-6d 2-ethvl ester To a solution of 0.104 g (0.413 mmol) of 6-Chloro-3-formyl-lH-indole-2-carboxylic aC1-6d ethyl ester in a mixture of tert-butanol (10 ml) and H2O (5 ml), was added 2-methyl-2-butene (2 ml) followed by a solution of NaC102 (0.344 g, 3.80 mmol) and NaH2P04 (0.399 g, 2.90 mmol) in water (2 ml). The mixture was stirred overnight at RT. The organic solvents were removed, and then the aqueous solution diluted with water, and washed twice with hexane. The ph of the aqueous phase was adjusted to 3 by addition of aq. HCl IN, and the product extracted with EtOAc. The combined organic phases were dried over Na2S04 and concentrated in vacuo to afford 15 mg (14%) of 6-chloro-lH-indole-2,3-dicarboxylic aC1-6d 2-ethyl ester as a light yellow solid. c^ lH-indole-2-carboxylic aC1-6d. 6-chloro-3-[r5-fluoro-3-oxospiro[isobenzofuran- l(3HV4'-piperidin]-r-vncarbonvl]-ethvl ester Amide coupling according to general procedure I described hereinabove: - Amine: 5-fluoro-3H-spiro[2-benzofuran-l,4-piperidin]-3-one prepared as described in WO2001014376, - AC1-6d: 6-chloro-lH-indole-2,3-dicarboxylic aC1-6d 2-ethyl Ester (the preparation of which is described hereinafter), d)6-chlorO"3-[(5-fluoro-3-oxo-l'H3H-spiro[2-benzofuran-l,4'-piperidin]-r-yncarbonvl]-lH-indole-2-carboxylic aC1-6d To a solution of 1.89 g (4.02 mmol) of lH-indole-2-carboxylic aC1-6d, 6-chloro-3-[(5-fluoro-3-oxospiro[isobenzofuran-l(3H),4'-piperidin]-l'-yl)carbonyl]-, ethyl ester in EtOH (150 ml), was added an aqueous solution of LiOH (7.8 ml, IM). The resulting white suspension was stirred at 80°C overnight, cooled to RT, and then poured in 500 ml aq. HCl (IN). The product was extracted with 3 times 500 ml of CH2C1-62, and the combined organic phases were dried over Na2S04 and concentrated in vacuo to afford 1.42 g (72%) of 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyI]-lH-indole-2-carboxylic aC1-6d as a white solid. ■ e^ l'-(^{6-chloro-2-[r4-methvlpiperidin-l-yncarbonvl]-lH-indol-3-vl}carbonylV5-fluoro- 3H-spiro[2-benzofuran-1.4'-piperidin]-3-one Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available 4-methyl-piperidine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in step d hereinabove), ES-MS m/e (%): 525 (M+H^) Example 25 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yI)carbonyl]-lH-indole-2-carboxainide Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6al available ammonium hydroxide, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%): 442 (M+H^). Example 26 6-chloro-N-[2-(dimethylamino)ethyl]-3-[(5-nuoro-3-oxo-l'H,3H-spiro[2- benzofuran-l,4*-piperidin]-l'-yl)carbonyl]-lH-indole-2-carboxamide Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available Nl, Nl-dimethyl-ethane-l,2-diamine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%):513 (M+H^. Example 27 l'-{[6-chIoro-2-(piperazin-l-ylcarbonyl)-lH-indol-3-yI]carbonyl}-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available piperazine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%):511 (M+H^. Example 28 l'-{[6-chloro-2-(morpholin-4-yicarbonyI)-lH-indol-3-yl]carbonyl}-5-fIuoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available morpholine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%):512 (M+H^- Example 29 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'- yl)carbonyI]-N,N-dimethyl-lH-indole-2-carboxamide Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available dimethylamine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%): 471 (M+H^- Example 30 tert-butyl{2-[({6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-ben2ofuran-l,4'- p!peridin]-l'-yl)carbonyI]-lH-indol-2-yl}carbonyl)amino]ethyI}methyIcarbamate Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available (2-Amino-ethyl)-methyl-carbamic aC1-6d tert-butyl ester, -AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-ben2ofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%): 599 (M+H^. Example 31 6-chloro-N,N-diethyl-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]- l'-yI)carbonyI]-lH-indoIe-2-carboxamide Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available diethyl-amine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%): 498 (M+H^- Example 32 l'-({6-chloro-2-[(4-methylpiperazin-l-yl)carbonyl]-lH-indoI-3-yl}carbonyI)-5- fluoro-3H-spiro[2-benzofuran-l,4'-pipendin]-3-one Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available 1-methyl-piperazine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%):524 (M+H^). Example 33 l'-{[6-chloro-2-(piperidin-l-ylcarbonyl)-lH-indol-3-yl]carbonyI}-5-fIuoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Amide coupling according to general procedure IV described hereinabove: - Amine: commerC1-6ally available piperidine, - AC1-6d: 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d (described in example 24), ES-MS m/e (%): 510 (M+H^. Example 34 l'-[(l-benzyl-2-methyI-lH-indol-3-yl)carbonyl]-7H-spiro[furo[3,4- fj[l,3]benzodioxole-5,4'-piperidin]-7-one Amide coupling according to general procedure I described hereinabove: - Amine: 7H-spiro[furo[3,4-f|[l,3]benzodioxole-5,4'-piperidin]-7-one prepared as described in DE2458176A1, - AC1-6d: 1-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 495 (M+H^). Example 35 3-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l'-yI)carbonyl]- lH-indoI-l-yl}propanenitrile To a stirred solution of 100 mg (0.26 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]-3-one (the preparation of which has been described in example 16) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 35 mg (0.26 mmol) of 3-bromo-propionitrile was added. The mixture was stirred an additional hour and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (CH2Cl2/MeOH, 99:1; SiOi) afforded 48 mg (29%) of 3-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}propanenitrile as a light yellow solid. ES-MS m/e (%): 434(M+H0. Example 36 4-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]- lH-indol"l-yI}butanenitrile To a stirred solution of 100 mg (0.26 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyI]-3H-spiro[2-benzofuran-l,4'-piperidine]-3-one (the preparation of which has been described in example 16) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 37 mg (0.26 mmol) of 4-bromo-butyronitrile was added. The mixture was stirred overnight and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (CH2Cl2/MeOH, 99:1; Si02) afforded 69 mg (59%) of 4-{6-chloro-3-[(3-oxo-lU3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl) carbonyI]-lH-indol-l-yl}butanenitrile as a light yellow solid. ES-MS m/e (%): 448(M+H*). Example 37 {6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]"l'-yl)carbonyl]-lH- indoI-l-yl}acetonitrile To a stirred solution of 100 mg (0.26 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]-3-one (the preparation of which has been described in example 16) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 31 mg (0.26 mmol) of bromo-acetonitrile was added. The mixture was stirred overnight and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (EtOAc/Hx, 1:6; Si02) afforded 58 mg (34%) of {6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}acetonitrile as a light yellow solid. ES-MS m/e (%): 420(M+H'). Example 38 2-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]- To a stirred solution of 100 mg (0.26 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]-3-one (the preparation of which has been described in example 16) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 35 mg (0.26 mmol) of 2-bromo-propionitrile was added. The mixture was stirred overnight and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (EtOAc/Hx, 2:1; Si02) afforded 54 mg (34%)of2-{6-chloro-3-[(3-oxo-rH3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl) carbonyl]-lH-indol-l-yl}propanenitrile as a light yellow solid. ES-MS m/e (%): 434(M+H0. Examples of compounds of formula (I-d) Example 39 l'-[(l-benzyl-2-methyl-lH-indoI-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] pepared as described in J. Org. Chem. 1976, 41, 2628, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1). ES-MS m/e (%): 437.5 (M+H^. Example 40 l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-chloro-3H-spiro[2-benzofuran- l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: 6-chloro-3H-spiro[2-benzofuran-l,4'-piperidine] prepared as described in WO2004004714, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1) ES-MS m/e (%): 471.3 (M+H^). Example 41 l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyi]-3-phenyl-3H-spiro[2-benzofuran- l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: 3-phenyl-3H-spiro[2-benzofuran-l,4'-piperidine] prepared as described in J. Med, Chem. 1976,19,1315, - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1) ES-MS m/e (%): 513.6 (M+H""). Example 42 l'-[(l-benzyl-5-methoxy-2-methyl-lH-indol-3-yI)carbonyl]-3H-spiro[2-benzofuran- l,4*-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] prepared as described in J. Org. Chem. 1976, 41, 2628, - AC1-6d: l-benzyl-5-methoxy-2-methyl-lH-indole-3-carboxylic aC1-6d (commerC1-6ally available), ES-MS m/e (%): 467.4 (M+H^). Example 43 l'-[(2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzoftiran-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] pepared as described in 7. Org. Chem. 1976, 41, 2628, - AC1-6d: 2-Methyl-lH-indole-3-carboxylic aC1-6d (described in J.Heterocyclic Chem. 1977, 14, 1123), ES-MS m/e (%): 347.3 (M+H^). Example 44 l'-[(l-benzoyl-2-methyI-lH-indol-3-yI)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidine] To a stirred solution of 40 mg (0.11 mmol) of r-[(2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (the preparation of which has been described in example 43) in 3 ml DMF was added 5 mg (0.11 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 19 mg (0.13 mmol) of benzoyl chloride was added. The mixture was stirred an additional hour and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Re-crystallization in EtaO afforded 51 mg (98%) of r-[(l-benzoyl-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] as white crystals. ES-MS m/e (%): 451.3 (M+H^). Example 45 l'-{[2-methyl-l-(phenylsuifonyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine] To a stirred solution of 40 mg (0.11 mmol) of r-[(2-methyl-lH-indol-3-yl)carboTiyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (the preparation of which has been described in example 43) in 3 ml DMF was added 5 mg (0.11 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 24 mg (0.14 mmol) of benzenesulfonyl chloride was added. The mixture was stirred an additional hour and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Re-crystallization in Et20 afforded 45 mg (80%) of r-{[2-methyl-l-(phenylsulfonyl)-lH-indol-3-yl]carbonyI}-3H-spiro[2-benzofuran-l,4'-piperidine] as white crystals. ES-MS m/e (%): 487.4 (M+H""). Example 46 l'-{[l-(cyC1-6ohexylmethyI)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4*-piperidine] Following the general procedure II described hereinabove above with bromomethyl-cyclohexane as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 443.5 (M+H^). Example 47 l'-{[l-(3-fluorobenzyI)-2-methyl-lH-indol-3-yl]carbonyI}-3H-spiro[2"benzofuran- l,4'-piperidine] Following the general procedure II described hereinabove with l-bromomethyl-3-fluoro-benzene as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 455.4 (M+H^). Example 48 l'-({2-methyl-l-[2-(trifluoromethoxy)benzyI]-lH-indoI-3-yl}carbonyI)-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with l-bromomethyl-2- trifluoromethoxy-benzene as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 521.4 (M+H^. Example 49 l'-{[l-(3,5-dimethylbenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H"Spiro[2- benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with l-bromomethyl-3,5-dimethyl-benzene as electrophile, the title compound was obtained as white solid. ES-MS m/e (%): 465.4 (M+H^. Example 50 methyl 4-{[2-methyl-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)- lH-indol-l-yl]methyl}benzoate Following the general procedure II described hereinabove with 4-bromomethyl-benzoic aC1-6d methyl ester as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 495.5 (M+H^. Example 51 4-{[2-methyl-3-(l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yl]methyI}benzoDitriIe Following the general procedure II described hereinabove with 4-bromomethyl-benzonitrile as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 462.4 (M+fT). Example 52 l'-{[l-(3,5-difluorobenzyI)-2-methyl-lH"indol-3-yI]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with l-bromomethyl-3,5-difluoro-benzene as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 473.4 (M+H^). Example 53 l'-{[l-(2-chlorobenzyl)-2-methyMH-indoI-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine] Following the general procedure II described hereinabove with l-bromomethyl-2-chloro-benzene as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 471.3 (M+H^). Example 54 l'-{[l-(2-methoxybenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4*-piperidine] Following the general procedure II described hereinabove with l-chloromethyl-2-methoxy-benzene as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 467.4 (M+H^). Example 55 l*-{[l-(4-methoxybenzyl)-2-methyl-lH-indol-3-yI]carbonyi}-3H-spiro[2-benzofuran- l,4'-piperidine] Following the general procedure II described hereinabove with l-chloromethyl-4-methoxy-benzene as electrophile; the title compound was obtained as white solid. ES-MS m/e (%): 467.4 (M+H^. Example 56 l'-[(l-{[2-(4-chlorophenyl)-l,3-thiazol-4-yl]methyl}-2-inethyl-lH-indol-3- yl)carbonyI]-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-2-(4-chloro-phenyl)-thiazole (commerC1-6ally available) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 554.3.(M+H0. Example 57 l'-[(l-{[2-(4-chlorophenyl).l,3-thiazol-4-yl]methyl}-2-methyl-lH.indol-3- yl)carbonyI]-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-broniomethyl-2-(4-chloro-phenyl)-5-methyl-thiazole (the preparation of which has been described in WO2004020420) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):.568.3 (M+H^). Example 58 l'-[(l-{[2-(2-inethoxyphenyl)-5-methyl-l,3-oxazoI-4-yl]inethyI}-2-methyl-lH-indoI- 3-yi)carbonyI]-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-2-(2-methoxy-phenyl)-5-methyl-oxa2ole (the preparation of which has been described in WO2002092084 & WO2004031162) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 548.5 (M+H^. Example 59 l-{[2-methyl-l-({5-methyl-2-[3-(trifluoromethyl)phenyl]-l,3-oxazol-4-yl}methyl)- lH-indoi-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4*-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-5-methyl-2-(3-trifluoromethyl-phenyl)-oxazole (the preparation of which has been described in WO2004031162) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):.586.3 (M+H^). Example 60 l'-[(l-{[2-(2-fluorophenyl)-5-inethyl-l,3-oxazol-4-yl]methy!}-2-methyl-lH-indol-3- yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-2-(2-fluoro-phenyl)-5-methyl-oxa2ole (commerC1-6ally available) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):.536.4 (M+H^. Example 61 l'-[(l-{[2-(4-isopropylphenyl)-5-methyI-l,3-oxazol-4-yl]methyl}-2-methyl-lH-indoI- 3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l54'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-2-(4-isopropyl-phenyl)-5-methyl-oxazole (the preparation of which has been described in WO2002092084 & WO2004031162) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):.560.4 (M+H^. Example 62 l'-[(l-{[2-(4-ethylphenyl)-5-methyl-l,3-oxazol-4-yl]methyI}-2-inethyl-lH-indoI-3- yI)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-2-(4-ethyl-phenyl)-5-methyl-oxazole (the preparation of which has been described in WO2002092084) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):.546.4 (M+H^). Example 63 l'-[(2-methyl-l-{[5-methyl-2-(2-methylphenyl)-l,3-oxazol-4-yl]methyl}-lH-indol-3- yl)carbonyI]-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-5-methyl-2-o-tolyl-oxazole (the preparation of which has been described in WO2004031162) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):532.3 (M+H^). Example 64 l'-{[2-inethyl-l-({5-methyl-2-[4-(trifluoromethyl)phenyl]-l,3-oxazoI-4-yI}methyl)- lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole (the preparation of which has been described in J. Med. Chem, 2000, 43, 995-1010) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):.586.3 (M+H^. Example 65 l-{[2-inethyl-l-({5-methyl-2-[2-(trifluoromethyl)phenyl]-l,3-oxazol-4-yl}methyl)- lH-indoI-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure II described hereinabove with 4-chloromethyl-5-methyl-2-(2-trifluoromethyl-phenyl)-oxazole (the preparation of which has been described in WO2004031162) as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%):.586.5 (M+H^). Example 66 l'-[(5-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] prepared as described in J.Org.Chem. 1976, 41, 2628, - AC1-6d: 5-Chloro-lH-indole-3-carboxylic aC1-6d (commerC1-6ally available), ES-MS m/e (%):.367.1 (M+H^. Example 67 l'-[(l-methyI-lH-indol-3-yi)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] prepared as described in J.Org.Chem. 1976, 41, 2628, - AC1-6d: l-Methyl-lH-indole-3-carboxylic aC1-6d (commerC1-6ally available), ES-MS m/e (%): 347.5 (M+H^. Example 68 l'-[(l-benzyl-lH-indol-3-yl)carbonyI]-3H-spiro[2-ben2ofuran-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] prepared as described in J.Org.Chem. 1976, 41, 2628, - AC1-6d: l-benzyl-lH-indole-3-carboxylic aC1-6d (described in example 3), ES-MS m/e (%): 423.6 (M+H^. Example 69 l'-[(6-chIoro-lH-indol-3-yI)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] prepared as described in J.Org.Chem. 1976, 41, 2628, - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (the preparation of which is described hereinafter), ES-MS m/e (%):.367.2 (M+H*). 6-chloro-lH-indole-3-carboxvlic aC1-6d Using a procedure described in J. Med. Chem, 1991, 34,140, from 7.0 g (0.046 mmol) of 6-chloro-lH-indole was prepared 5.80 g (64%) of 6-chloro-lH-indole-3-carboxylic aC1-6d as a light brown solid. ES-MS m/e (%): 194 (M-H^. Example 70 l'-(lH-indoI-3-ylcarbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] prepared as described in J. Org, Chem. 1976, 41, 2628, - AC1-6d: lH-Indole-3-carboxylic aC1-6d (commerC1-6ally available). ES-MS m/e (%):.333.3 (M+H^). Example 71 N,N-dimethyl-2-[3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH- indoI-l-yl]ethanamine To a stirred solution of 20 mg (0.060 mmol) of l'-(lH-indol-3-ylcarbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine] (the preparation of which has been described in example 70) in DMF (3 ml) at RT, was added 2.9 mg (0.072 mmol) of NaH (60% in oil). The mixture was stirred 20 min. and then 13 mg (0.072 mmol) of (2-chloro-ethyl)-dimethyl-amine in 1 ml of DMF was added. The mixture was stirred an additional 5 hours at 50°C and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (CH2C1-62 / MeOH 8/2) afforded 11 mg (48%) of N,N-dimethyl-2-[3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]ethanamine as a viscous oil. ES-MS m/e (%): 404.3 (M+H^). Example 72 2-methyl-l-[3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- 2-yl]butan-l-one Amide coupling according to general procedure I described hereinabove: - Amine: spiro[isobenzofuran-l(3H),4'-piperidine] prepared as described in J. Org, Chem, 1976, 41, 2628, - AC1-6d: 2-(2-Methyl-butyryl)-lH-indole-3-carboxylic aC1-6d (commerC1-6ally available), ES-MS m/e (%):.417 (M+H^. Example 73 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yl]propanenitrile To a stirred solution of 100 mg (0.26 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (the preparation of which has been described in example 69) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 35 mg (0.26 mmol) of 2-bromo-propionitrile was added. The mixture was stirred overnight and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (EtOAc/Hx, 1:1; Si02) afforded 93 mg (91%)of2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l-ylcarbonyl)-lH-indol-1-yl] propanenitrile as a light yellow solid. ES-MS m/e (%): 420(M+H0. Example 74 3-[6-chlora-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol- 1-yl] propanenitrile To a stirred solution of 100 mg (0.26 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (the preparation of which has been described in example 69) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 35 mg (0.26 mmol) of 3-bromo-propionitrile was added. The mixture was stirred for two days at RT and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (EtOAc/Hx, 2:1; Si02) afforded 105 mg (96%) of 3-[6-chloro-3-(lH3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl] propanenitrile as a white solid. ES-MS m/e (%): 420(M+H0. Example 75 4-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yl]butanenitrile To a stirred solution of 100 mg (0.26 mmol) of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'-piperidine] (the preparation of which has been described in example 69) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 35 mg (0.26 mmol) of 4-bromo-butyronitrile was added. The mixture was stirred for two days at RT and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (EtOAc/Hx, 2:1; Si02) afforded 99 mg (88%) of 4-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]butanenitrile as a white solid. ES-MS m/e (%): 434(M+H0. Example 76 [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l- yl]acetonitrile To a stirred solution of 100 mg (0.26 mmol) of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (the preparation of which has been described in example 69) in 5 ml DMF was added 11.5 mg (0.28 mmol) NaH (60% in oil). The mixture was stirred at RT for 30 min. and then 35 mg (0.26 mmol) of bromo-acetonitrile was added. The mixture was stirred overnight at RT and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo. Flash chromatography (EtOAc/Hx, 2:1; Si02) afforded 43 mg (41%)of [6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-1-yl] acetonitrile as a white solid. ES-MS m/e (%): 406(M+H0. Examples of compounds of formula (I-e) Example 77 l'-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine] Amide coupling according to general procedure 1 described hereinabove: - Amine: commerC1-6ally available spiro[l-benzofuran-3,4'-piperidine], - AC1-6d: 6-chloro-lH-indole-3-carboxylic aC1-6d (described in example 5), ES-MS m/e (%): 367.4 (M+H^. Example 78 l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: commerC1-6ally available spiro[l-benzofuran-3,4'-piperidine], - AC1-6d: l-Benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (described in example 1), ES-MS m/e (%): 437.6 (M+H^). Example 79 l'-(lH-indol-3-ylcarbonyl)spiro[l-benzofuran-3,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: commerC1-6ally available spiro[l-benzofuran-3,4'-piperidine], - AC1-6d: lH-Indole-3-carboxylic aC1-6d (commerC1-6ally available), ES-MS m/e (%): 333.4 (M+H^). Example 80 l'-[(6-chloro-5-fluoro-lH-indol-3-yl)carbonyI]spiro[l-benzofuran-3,4'-piperidine] Amide coupling according to general procedure I described hereinabove: - Amine: commerC1-6ally available spiro[l-benzofuran-3,4'-piperidine], - AC1-6d: 6-chloro-5-fluoro-lH-indole-3-carboxylic aC1-6d (the preparation of which is described hereinafter), ES-MS m/e (%): 385.1 (M+H^. 2L) 6-chloro-5-fluoro-lH-indole: Following the procedure described in W09747598, from 6-chloro-5-fluoro-lH-indole- 2,3-dione was prepared 6-chloro-5-fluoro-lH-indole. b^ 6-chloro-5-fluoro-lH-indole-3-carboxvlic aC1-6d: Following a procedure described in J. Med. Chem. 1991, 34, 140, from 0.25 g (1.47 mmol) of 6-chloro-5-fluoro-lH-indole was prepared 0,35 g (90%) of 6-chloro-5-fluoro- lH-indole-3-carboxylic aC1-6d as a light brown solid. ES-MS m/e (%): 213 (M-H"*"). Example 81 2-[6-chloro-3-(l'H-spiro[l-benzofuran-3,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yI]- N,N-diinethyIethanamine Following the general procedure III as described hereinabove with commerC1-6ally available (2-chloro-ethyl)-dimethyl*amine as electrophile, the title compound was obtained as colorless viscous oil. ES-MS m/e (%): 438.1 (M+H^). Example 82 l'-{[6-chloro-l-(2-pyrrolidin-l-ylethyl)-lH-indol-3-yl]carbonyI}spiro[l-benzofuran- 3,4*-piperidine] Following the general procedure III as described hereinabove with commerC1-6ally available l-(2-chloro-ethyl)-pyrrolidine as electrophile, the title compound was obtained as a colorless viscous oil. ES-MS m/e (%): 464.0 (M+H^). Example 83 Following the general procedure VII as described above, the sulphonylation of r-[(6- chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 3,5-difluoroben2enesulfonyl chloride gave the title compound. ES-MS m/e (%): 542.4(M-H^). Example 93 l'-{[6-Chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 3,5-difluorobenzyl chloride gave the title compound. ES-MS m/e (%): 492.4(M+H0. Example 94 l-{[6-Chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole- 3,4'-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 3-fluorobenzyl chloride gave the title compound. ES-MS m/e (%): 474.4(M+H^). Example 95 2-[6-Chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-l'-ylcarbonyl)-lH- indol-l-yl]-l-(3,5-difluorophenyl)ethanone Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 2-chloro-l-(3, 5-difluoro-phenyl)-ethanone gave the title compound. ES-MS m/e (%): 520.4(M+H0. Example 96 2-[6-Chloro-3-(l,2-dihydro-l'H"Spiro[indole-3,4'-piperidin]-l'-ylcarbonyl)-lH- indol-l-yl]-l-(3,4-difluorophenyI)ethanone Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 2-chloro-l-(3, 4-difluoro-phenyl)-ethanone gave the title compound. ES-MS m/e (%): 520.4(M+ir). Example 97 2-[6-Chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-l*-ylcarbonyl)-lH- indol-l-yl]-l-(2-fluorophenyl)ethanone Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 2-chloro-l-(2-fluoro-phenyl)-ethanone gave the title compound. ES-MS m/e (%): 502.5(M+H0. Example 98 2-[6-Chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-l'-ylcarbonyl)-lH- indol-l-yI]-N,N-diethylethanamine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available diethylaminoethyl bromide gave the title compound. ES-MSm/e(%): 465.4(M+H'). Example 99 2-[6-Chloro-3-(l,2-dihydro-l'H-spiro[!ndole-3,4'-piperidin]-l'-ylcarbonyl)-lH- indol-l-yl]-NjN-diethylacetamide Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 2-chloro-A^^-diethyl-acetamide gave the title compound. ES-MS m/e (%): 479.5 (M+H^). Example 100 2-[6-Chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-l'.ylcarbonyl)-lH- indoI-l-yl]-N,N-dimethylacetamide Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 2-chloro-A^^-diethyl-acetamide gave the title compound. ES-MSm/e(%): 451.5(M+H'). Example 101 2-[6-Chloro-3-(l,2-dihydro-lH-spiro[indole-3,4'-piperidin]-l'-ylcarbonyl)-lH- indol-l-yl]-l-pyridin-2-ylethanone Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 2-chloro-l-pyridin-2-yl-ethanone gave the title compound. ES-MS m/e (%): 485.4(M+H^). Example 102 l-{[6-Chloro-l-(pyridin-3-ylinethyi)-lH-indoI-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine] Following the general procedure III as described above, the alkylation of 1-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with commerC1-6ally available 3-bromomethyl-pyridine gave the title compound. ES-MS m/e (%): 457.2(M+H0. Example 103 l-{[6-Chloro-l.(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-l,2-dihydrospiro[indole-3,4'-piperidine] (prepared according to example 8) with methanesulfonic aC1-6d pyridin-2-ylmethyl ester (described in WO 9955318) gave the title compound. ES-MS m/e (%): 457.2(M+H0. Examples of compounds of formula (I-c) Example 104 l'-{[6-Chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure V as described hereinabove, the alkylation of r-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which has been described in example 16) with commerC1-6ally available 2-chloro-1-piperidin-l-yl-ethanone as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 506.0 (M+H^. Example 105 l'-{[6-Chloro-l-(2-morpholin-4-yl-2-oxoethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperldin]-3-one Following the general procedure V as described hereinabove, the alkylation of l'-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which has been described in example 16) with commerC1-6ally available 2-chloro-l-morpholin-4-yl-ethanone as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 508.1 (M+H^). Example 106 2-{6-ChIoro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4*-piperidin]-l'-yl)carbonyl]- lH-indol-l-yl}-N,N-diinethylacetamide Following the general procedure V as described hereinabove, the alkylation of r-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which has been described in example 16) with commerC1-6ally available 2- chloro-N,N-dimethyl-acetamide as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 466.1 (M+H^. Example 107 2-{6-Chloro-3-[(3-oxo-l'H,3H-spiro[2"benzofuran-l,4'-piperidin]-l'-yl)carbonyl]- lH-indol-l-yl}-N,N-(iiethylacetainide Following the general procedure V as described hereinabove, the alkylation of r-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which has been described in example 16) with commerC1-6ally available 2-chloro-N,N-diethyl-acetamide as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 494.1 (M+H^). Example 108 l'-{[6-Chloro-l-(piperidin-l-ylcarbonyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure V as described hereinabove, the alkylation of r-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which has been described in example 16) with commerC1-6ally available piperidine-1-carbonyl chloride as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 492.1 (M+H""). Example 109 tert-Butyl {6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidiii]-l'- yl)carbonyl]-lH-indol-l-yl}acetate Following the general procedure V as described hereinabove, the alkylation of r-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran4,4'-piperidin]-3-one (the preparation of which has been described in example 16) with commerC1-6ally available chloro-acetic aC1-6d tert-butyl ester as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 495.2 (M+lT). Example 110 2-{6-Chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4-piperidin]-l'-yl)carbonyl]-lH-indoI-l-yI}-N,N-dimethylacetamide Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which has been described in example 19) with commerC1-6ally available 2-chloro-N,N-dimethyl-acetamide as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 484.0 (M+H^. Example 111 l'-({6-Chloro-l-[2-(dimethylamino)ethyl]-lH-indol-3-yl}carbonyI)-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one (the preparation of which have been described in example 19) with commerC1-6ally available (2-chloro-ethyl)-dimethyl--amine as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 470.1 (M+H^. Example 112 tert-Butyl{6-chIoro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]- l'-yl)carbonyl]-lH-indol-l-yI}acetate Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which have been described in example 19) with commerC1-6ally available chloro-acetic aC1-6d tert-butyl ester as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 513.2 (M+H^). Example 113 l'-{[6-Chloro-l-(2-morphoIin-4-yI-2-oxoethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure V as described hereinabove, the alkylation ot i -[(D-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one (the preparation of which have been described in example 19) with commerC1-6ally available 2-chloro-l-morpholin-4-yl-ethanone as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 526.2 (M+H^). Example 114 l'-({6-Chloro-l-[2-(4-methylpiperazin-l-yI)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-5- fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which have been described in example 19) with commerC1-6ally available 2-chloro-l-(4-methyl-piperazin-l-yl)-ethanone as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 539.4 (M+H^. Example 115 2-{6-Chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidln]-l'- yl)carbonyl]-lH-indol-l-yl}acetamide Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which have been described in example 19) with commerC1-6ally available chloro-acetic aC1-6d methyl ester as electrophile, an ester intermediate methyl {6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}acetate was obtained as a white solid. This intermediate compound, methyl {6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-ben2ofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}acetate, was then hydrolysed using standard conditions (aq.NaOH IM, MeOH, room temperature) to give {6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl} acetic aC1-6d as a white solid. An amide coupling between {6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}acetic aC1-6d and NH4OH (25% in water) afforded the title coumpound as a white solid. ES-MS m/e (%): 456.4 (M+H^. Example 116 2-{6-Chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran"l,4'-piperidin]-l'-yl)carbonyI]-lH-indol-l-yl}-N-methylacetamide An amide coupling between {6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}acetic aC1-6d (described herein above) and methyl amine afforded the title coumpound as a white solid. ES-MS m/e (%): 470.3 (M+H""). Example 117 l'-{[6-Chloro-l-(2-oxo-2-piperazin-l-ylethyI)-lH-indol-3-yI]carbonyl}-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (the preparation of which have been described in example 19) with commerC1-6ally available 4-(2-Chloro-acetyl)-piperazine-l-carboxylic aC1-6d tert-butyl ester as electrophile, the title compound was obtained as a white solid after removal of the Boc protecting group under standard conditions (TFA/ dichloromethane, room temperature). ES-MS m/e (%): 525.1 (M+H^. Example 118 2-{6-Chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}-N-[2-(dimethylamino)ethyl]acetamide An amide coupling between {6-chloro-3-[(5-fluoro-3'-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}acetic aC1-6d (described herein above) and N,N-dimethyl-ethane-l,2-diamine afforded the title coumpound as a white solid. ES-MS m/e (%): 527.2 (M+H'). Example 119 2-{6-Chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}-N-[2-(dimethyIamino)ethyl]acetamide An amide coupling between {6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}acetic aC1-6d (described herein above) and N,N-dimethyl-ethane-l,2-diamine afforded the title coumpound as a white solid. ES-MS m/e (%): 509.2 (M+H^). Example 120 2-{6-Chloro-5-methyI-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4*-piperidin]-l'-yI)carbonyl]-lH-indol-l-yl}-N,N-dimethylacetamide a) l-(6-Chloro-5-methvl-lH-indol-3-vlV2.2,2-trifluoro-ethanone Using a procedure described in J. Med. Chem. 1991, 34, 140, from 0.250 g (0.002 mol) of 6-chloro-5-methyl-lH-indole were prepared 0.38 g (96%) of l-(6-chloro-5methyl-lH-indol-3-yl)-2,2,2-trifluoro-ethanone as a white solid. b)2-[6-Chloro-5-methvl-3-(Z2,2-trifluoro-acetylVindol-l-vl]-RN-dimethvl-acetamide To a stirred solution of l-(6-chloro-5methyl-lH-indol-3-yl)-2,2,2-trifluoro-ethanone (0.38 g) in 10 ml of DMF at 0°C were added 64 mg (1.1 eq.) of NaH (60% in oil). After stirring the mixture for 30 min. were added 0.16 ml (1.1 eq.) of dimethylamino-acetyl chloride. The mixture was stirred for an additional hour and then poured onto water and extracted with ethyl acetate. The combined organic phases were dried over Na2S04 and concentrated in vacuo to afford 300 mg (60%) of the title compound as a white solid. c) 6-Chloro-l-dimethvlcarbamovlmethvl-5-methvl"lH-indole-3-carboxvlicaC1-6d Using a similar procedure as described in J. Med, Chem. 1991, 34, 140, from 0,280 g of 2-[6-chloro-5-methyl-3-(2,2,2-trifluoro-acetyl)-indol-l-yl]-N,N-dimethyl-acetamide were prepared 0.18 g (76%) of the title compound as a white solid. d) 2-{6-chloro-5-methvl-3-[(3-oxo-l'H3H-spiro[2-benzofuran-1.4'-piperidin]-r- vHcarbon vl] - IH-indol-1 -vl} -N.N-dimeth vlacetamide Amide coupling according to general procedure I described hereinabove; - Amine: 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in J. Org, Chem, 1976, 41, 2628, - AC1-6d: 6-Chloro-l-dimethylcarbamoylmethyl-5-methyl-lH-indole-3-carboxylic aC1-6d, ES-MS m/e (%): 480.3 (M+H^). Example 121 l'-[(l-Benzyl-2-methyl-lH-indol-3-yI)carbonyl]-5-bromo-3H-spiro[2-benzofuran- 1,4' -piperidin] -3-one a) 5-Bromo-r-methvl-3H-spiro[2-benzofuran-1.4'-piperidin]-3-one Butyllithium (97.2 ml of 1.47 M solution in hexane, 143 mmol) was added dropwise to a solution of 2,5-Dibromo-ben2oic aC1-6d (20 g, 72 mmol) in dry THF (300 ml) at -78° C over a period of 3.5 h under a nitrogen atmosphere. The reaction mixture was stirred at -78 °Cfor 2 h. A solution of N-methyl piperidone (11.31 g, 99 mmol) in hexane (40 mL) was added dropwise during 30 min to the reaction mixture at -78 °C. The reaction mixture was allowed to come to room temperature and stirring was continued for overnight. The reaction mixture was added to a mixture of water (500 ml) and ether (300 mL). The aqueous layer was extracted with ether (5 X 150 mL) and aC1-6dified with concentrated HC1-6 (to pH 2-3) and extracted with ether (2 X 150 ml). The aC1-6dic solution was boiled for 1 h and then cooled to 0-5 °C and made alkaline (to pH 9-10) with aqueous NaOH. The cold solution was rapidly extracted with chloroform (5 X 300 mL). The combined chloroform extracts were washed with water (150 ml), dried over sodium sulfate and evaporated under reduced pressure. The residue was purified was purified by silica gel (100-200) column chromatography eluting with methanol in dichloromethane (0.5% to 2.5%) to afford the desired product (4.2 g, 20%). ^H-NMR (400MHz, CDC1-63): 5 1.71 (d, J = 14.2 Hz, 2H), 2.15-2.24 (m, 2H), 2.37 (s, 3H), 2.45-2.52 (m, 2H), 2.83-2.87 (m, 2H), 7.26 (d, J = 8.25 Hz, IH), 7.75 (dd, J = 7.8, 1.7 Hz, IH). ^-^C-NMR (lOOMHz, CDC1-63): 5 35.95, 46.05, 51.42, 84.00, 122.54, 122.97, 127.52, 128.64,137.06,152.24, 167.77. h) 5-Bromo-3-oxo-rH,3H-spiro[2-benzofuran-1.4'-piperidine]-r-carbonitrile A solution of the N-methylpiperidine (3.0 g, 10 mmol) in choloroform (50 ml) was added dropwise to a stirred boiling solution of cyanogen bromide (12.16 g, 120 mmol) in chloroform (100 ml) under a nitrogen atmosphere and the resulting solution was refluxed for overnight. The reaction mixture was cooled and washed with 25 mL of 5% HCl and then with 20 ml of water. The organic layer was dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (100-200) eluting with methanol in dichloromethane (0.5% to 1.0%) to get the pure product (1.6 g, 51%). ^H-NMR (400MHz, CDC1-63): 6 1.72 (d, J = 14.2Hz, 2H), 2.24-2.32 (m, 2H), 3.37-3.59 (m, 4H), 7.32 (d, J = 8.2 Hz, IH), 7.83 (dd, J = 8.0, 1.7Hz, IH), 8.03 (d, J = 1.7Hz, IH). c) 5-Bromo-3H-spiro[2-benzofuran-1.4'-piperidin]-3-one A mixture of cyanoamine (1.0 g, 3.2 mmnol) and 20%HC1-6 (12 ml) was heated under reflux under a nitrogen atmosphere for 6 h. The reaction mixture was cooled to 0-5 "^C and pH was adjusted to 9-10 with aqueous NaOH solution and rapidly extracted with chloroform (3 X 50 ml). The combined extracts were washed with water, the organic layer was dried over sodium sulfate and evaporated under reduced pressure. The residue was washed with distilled hexane and dried under high vacuum to get the pure product (0.64 g, 70%). IR (KBr) 3333.84, 290.53, 283525, 2811.07, 2749.38, 1756.04, 1470.28, 1415.14, 1271.03, 1196.28, 1083.84, 929.07, 831.50, 792.35, 734.78, 691.24, 548.46, 534.50 cm"\ ^H-NMR (400MHz, CDC1-63): 5 1.66-1.72 (m, 2H), 2.02-2.09 (m, 2H), 3.07-3.18 (m, 4H), 7.29 (d, J = 7.8 Hz, IH), 7.77 (dd, J = 7.8, 1.7 Hz, IH), 7.99 (d, J = 1.7Hz, IH). '^C-NMR (lOOMHz, CDC1-63): 5 6.33, 42.49, 85.23, 122.61, 122.93, 127.39, 128.64, 137.07, 152.44, 167.91. RA-MS: 282.1 and 284.1; C12 Hi2^'^BrN02 [MH^] requires 282.1. mp: 162-163 °C. d) r-[(l-Ben2yl-2-methvl-lH-indol-3-vncarbonvl]-5-bromo-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure I as described above, the acylation of 5-bromo-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with l-benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (preparation described in example 1), gave the title compound. ES-MSm/e(%): 531.5(M+H0. Example 122 l'-[(l-benzyI-2-methyl-lH-indol-3-yI)carbonyI]-6-(2-hydroxyethoxy)-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one a) 6-fluoro-l'-methvl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one To a solution of the substituted 2-broino-4-fluoro-benzoic aC1-6d (10,9 g, 50 mmol) in dry THF (200 ml) at -78 °C n-butyllithium (1.6 M in hexanes) (lOOmmol) was added drop wise (3 h) and the resulting solution was stirred for an additional 2 h at the same temperature. Freshly distilled N-methyl 4- piperidone (7.91 g, 70mmol) in dry hexane (25 ml) was added over 30 min at the same temperature. The mixture was then allowed to stir at rt and was finally added to ether (200 ml) and water (300 ml). The basic (aqueous) layer was extracted with ether (5 X 100 ml) and the aqueous layer was aC1-6dified with concentrated hydrochloric aC1-6d (pH 2-3) and extracted with ether. The aqueous solution was boiled for 1 h and was then cooled to 0-5 °C and made alkaline (pH 9-10) with cold aqueous sodium hydroxide. The cold solution was rapidly extracted with chloroform (5 X 200 ml). The combined chloroform extracts were washed with water, dried, concentrated to give light yellow solid which was purified over neutral alumina eluting with a gradient of 30-50% ethyl acetate-hexane to obtain 1.75 g (15%) of the desired product as a white solid. ^H-NMR (CDC1-63, 400 MHz): 5 1.68-1.75 (m, 2H), 2.18-2.19 (m, IH), 2.38 (s, 3H), 2.44-2.52 (m, 2H), 2.68-2.84 (m, 2H), 2.84-2.85 (m, IH), 7.02-7.05 (m, IH), 7.19-7.22 (m, IH), 7.84-7.87 (m, IH); FIA-MS: 236 (M + 1). b) 6-Fluoro-3-oxo-rH3H-spiro[2-benzofuran-l,4'-piperidine]"l'-carbonitrile To a solution of the 6-fluoro-l'-methyl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (1.17 g, 5 mmol) in dry chloroform (10 ml) was added cyanogenbromide (60 mnol) and the resulting solution was refluxed for 36 h. The reaction mixture was extracted with 5% HC1-6 (5 ml) and then with water (2.5 ml). The chloroform solution was dried (anhydrous MgS04) and concentrated to give a pale yellow soild which was chromatographed over Si02 eluting with 1% MeOH-dichloromethane to give 858 mg (70%) the desired product as a white solid. ^H-NMR (CDC1-63, 400 MHz): 5 1.72-1.76 (m, 2H), 2.22-2.30 (m, IH), 3.48-3.60 (m, 4H), 7.09-7.11 (m, IH), 7.11-7.28 (m, IH), 7.89-7.92 (m, IH); IR (KBr): 3492, 3043, 2216, 1760, 1602, 1478 cm'c) 5-(2-hvdroxvethoxvV3H-spiro[2-benzofuran-1.4'-piperidin]-3-one 6-Fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidine]-r-carbonitrile (1.23 g, 5 mmol) was heated with ethylene glycol (5 ml) and sodium hydroxide (0.82 g, 20.5 mmol) for 15-20 min at 130 °C. Most of the ethylene glycol was removed by distillation under high vaccum. The residual reaction mixture was diluted with water and extracted repeatedly with chloroform. The combined organics was dried and concentrated to give a semi solid material which was purified over AI2O3 column upon elution with 5-7% MeOH/CH2Cl2 containing NH3 (aqueous) to yield 789 mg (60%) of the desired product as a pale yellow solid. ^H-NMR (d6-DMS0, 400 MHz): 5 1.47-1.50 (m, 2H), 2.03-2.10 (m, 2H), 2.79-2.85 (m, 2H), 2.95-2.97 (m, 2H), 3,73-3.76 (m, 2H), 4.12-4.14 (m, 2H), 7.09 (d, J = 8.4 Hz, IH), 7.20 (s, IH), 7.69 (d, J = 8.4 Hz, IH); ^^C-NMR (d6-DMS0, 100 MHz): 5 35.9, 42.3, 59.3, 70.4, 84.6,106.4,116.6, 117.0,126.8, 156.9, 163.9, 168.5; FIA-MS: 264.3 (M + 1). d) r-[a-Benzvl-2-methyl-lH-indol-3-vncarbonvl]-6-f2-hvdroxvethoxvV3H-spiro[2- benzofuran-1.4'-piperidin]-3-Qne Following the general procedure I as described above, the acylation of 5-(2-hydroxyethoxy)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with l-benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (preparation described in example 1), gave the title compound. ES-MS m/e (%): 511.6(M+H^). Example 123 l'-({l-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methoxy-2-methyl-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure I as described above, the acylation of 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in example 16 above, with commerC1-6ally available l-[2-(3,4-dimethoxy-phenyl)-ethyl]-5-methoxy-2-methyl-l//-indole-3-carboxylic aC1-6d, gave the title compound. ES-MS m/e (%): 555.3 (M+H^. Example 124 l'-{[l-(4-Ethoxyphenyl)-5-methoxy-2-methyI-lH-indol-3-yl]carbonyI}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure I as described above, the acylation of 3H-spiro[2-benzofuran-l,4'-piperidin]"3-one prepared as described in example 16, with commerC1-6ally available l-(4-ethoxyphenyl)-5-methoxy-2-methyl-l//-indole-3-carboxylic aC1-6d, gave the title compound. ES-MS m/e (%): 511.5 (M+H^. Example 125 5-Bromo-l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one Following the general procedure I as described above, the acylation of 5-bromo-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one with lH-indole-3-carboxylic aC1-6d (commerC1-6ally available), gave the title compound. ES-MS m/e (%): 459.3(M+H^). Example 126 l'-[(l-Benzyl-2-methyl-lH-indoI-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'- piperidin]-3-one Following the general procedure I as described above, the acylation of 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in example 16 above with 1-benzyl-2-methyl-lH-indole-3-carboxylic aC1-6d (preparation described in example 1), gave the title compound. ES-MS m/e (%): 451.6(M+H^). Example 127 l'-{[6-Chloro-l-(355-difluorophenyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VI as described above, the arylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 3,5-difluorophenylboronic aC1-6d gave the title compound. ES-MS m/e (%): 493.1(M+H0. Example 128 l'-{[6-chIoro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylation of l'-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one (prepared according to example 16 above) with commerC1-6ally available 3-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 503.4(M+H^). Example 129 l'-{[6-Chloro-l-(2-fluorobenzoyl)-lH-indol-3-yI]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylation of r-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 2-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 503.4(M+H0. Example 130 l'-{[6-Chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 3,5-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 521.4(M+H^). Example 131 l'-{[6-Chloro.l-(2,3-difluorobenzoyl)-lH-indoI-3-yI]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidiii]-3-one Following the general procedure VII as described above, the acylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 2,3-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 521.4(M+H0. Example 132 l'-({6-Chloro-l-[(3,5-difluorophenyI)sulfonyl]-lH-indol-3-yl}carbonyI)-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the sulphonylation of r-[(6- chloro-lH-indoI-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16 above) with commerC1-6ally available 3,5- difluorobenzenesulfonyl chloride gave the title compound. ES-MS m/e (%): 557.4(M+H"'). Example 133 l'-{[6-Chloro-l-(3,5-difluorobenzyl)-lH-indoI-3-yl]carbonyI}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the acylation of r-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16 above) with commerC1-6ally available 3,5-difluorobenzyl chloride gave the title compound. ES-MS m/e (%): 507.4(M+H0. Example 134 1-{[6-Chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyI}-3H-spiro[2-ben2ofuran- l,4'-piperidin]-3-one Following the general procedure III as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 3-fluorobenzyl chloride gave the title compound. ES-MS m/e (%): 489.4(M+H^). Example 135 l'-({6-Chloro-l-[2-(3-fluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the acylation of l'-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 2-chloro-l-(3-fluoro-phenyl)-ethanone gave the title compound. ES-MSm/e(%): 517.4(M+H0. Example 136 l-({6-Chloro-l-[2-(2,5-difluorophenyl)-2-oxoethyl]-lH-indol-3-yI}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the acylation of r-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 2-chloro-l-(2,5-difluoro-phenyl)-ethanoneethanone gave the title compound. ES-MS m/e (%): 535.4(M+H^). Example 137 l'-{[6-Chloro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one i, Following the general procedure VII as described above, the acylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example ^9) with commerC1-6ally available 3-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 521.4(M+H"'). Example 138 l'-{[6-Chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyI}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 2-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 521.4(M+H*'). Example 139 r-{[6-ChIoro-l-(2,3-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 3,5-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 539.4(M+H^). Example 140 l'-{[6-Chloro-l-(2,3-difluorobenzoyl)^lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 2,3-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 539.3(M+H^). Example 141 l'-({6-Chloro-l-[(3,5-difluorophenyl)sulfonyl]-lH-indol-3-yl}carbonyl)"5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the sulphonylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 3,5-difluorobenzenesulfonyl chloride gave the title compound. ES-MS m/e (%): 575.3(M+H^). Example 142 l'-{[6-Chloro-l-(3,5-difluoroben2yl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 3,5-difluorobenzyl chloride gave the title compound. ES-MS m/e (%): 525.4(M+H^). Example 143 l'-{[6-ChIoro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 3-fluorobenzyl chloride gave the title compound. ES-MS m/e (%): 507.4(M+H^). Example 144 1-({6-Chloro-l-[2-(3-fluorophenyl)-2-oxoethyl]-lH-indol-3-yI}carbonyl)-5-fluoro- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 2-chloro-l-(3-fluoro-phenyl)-ethanone gave the title compound. ES-MS m/e (%): 535.4 (M+H^). Example 145 5-Bromo-l'-{[6-chloro-l-(3-fluorobenzoyl)-lH-indol-3-yI]carbonyI}-3H-spiro[2- benzoftiran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylation of 5-bromo-r-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with commerC1-6ally available S-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 581.2(M+H^). Example 146 5-Bromo-l'-{[6-chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4*-piperidin]-3-one Following the general procedure VII as describeed above, the acylation of 5-bromo-l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H"Spiro[2-benzofuran-l,4'-piperidin]-3-onewith commerC1-6ally available 3-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 581.2(M+H*). Example 147 5-Bromo-l'-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as describeed above, the acylation of S-bromo-l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with commerC1-6ally available 3,5-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 599.2(M+H^). Example 148 5-Broino-l'-{[6-chloro-l-(2,3-difluorobenzoyl)*lH-indol-3-yI]carbonyI}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as describeed above, the acylation of S-bromo-l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with commerC1-6ally available 2,3-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 599.2(M+H0 Example 149 5-Bromo-r-({6-chloro-l-[(3,5-difluorophenyl)sulfonyl]-lH-indol-3-yl}carbonyI)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the sulphonylation of 5-bromo-r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with commerC1-6ally available 3,5-difluorobenzenesulfonyl chloride gave the title compound. ES-MS m/e (%): 635.2(M+H^). Example 150 5"Bromo-r-{[6-chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of 5-broTno-l'-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with commerC1-6ally available 3,5-difluorobenzyl chloride gave the title compound. ES-MS m/e (%): 585.2(M+H^). Example 151 5-Bromo-r-{[6-chloro-l-(3-fluorobenzyI)-lH-indoI-3-yl]carbonyI}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of 5-bromo-r-[(6- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with commerC1-6ally available 3-fluorobenzyl chloride gave the title compound. ES-MS m/e (%): 567.3(M+H^). Example 152 5-Bromo-l'-({6-chloro-l-[2-(3-fluorophenyl)-2-oxoethyl]-lH-indol-3-yI}carbonyl)- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of 5-bromo-l'-[(6- chloro-lH-indoI-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one with commerC1-6ally available 2-chloro-l-(3-fluoro-phenyl)-ethanone gave the title compound. ES-MS m/e (%): 595.3(M+H0. Example 153 l'-({6-Chloro-l-[2-(2-fluorophenyl)-2-oxoethyl]-lH-indol-3-yI}carbonyI)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in example 16 with commerC1-6ally available 2-ch]oro-l-(3-fluoro-pheny])-ethanone gave the title compound. ES-MS m/e (%): 517.4(M+H0. Example 154 l'-({6-Chloro-l-[2-(3,4-difluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one prepared as described in example 16 above with commerC1-6ally available 2-chloro-l-(3, 4-difluoro-phenyl)-ethanone gave the title compound. ES-MS m/e (%): 535.4(M+H^). Example 155 r-{[6-Chloro-l-(3-fluorophenyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidin]-3-one Following the general procedure VI as described above, the arylation of I'-Kb-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16 above) with commerC1-6ally available 3-fluorophenylb()rt)nic aC1-6d gave the title compound. ES-MS m/e (%): 475.0(M+H^). Example 156 l'-[(l-Biphenyl-3-yl-6-chloro-lH-indoI-3-yl)carbonyl]-3H-spiro[2-benzofuran-L4 - piperidin]-3-one Following the general procedure VI as described above, the arylation of r-[(6-chkirt>- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 3-biphenylboronic aC1-6d gave ilu title compound. ES-MS m/e (%): 533.0(M+H^). Example 157 l'-[(l-Biphenyl-2-yl-6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2"benzofuran-1.4 - piperidin]-3-one Following the general procedure VI as described above, the arylation of r-[(6"chl(>n)- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 2-biphenylboronic aC1-6d gave ihe title compound. ES-MS m/e (%): 533.0(M+H^). Example 158 l'-{[l-(Biphenyl-3-ylcarbonyl)-6-chloro-lH-indol-3-yl]carbonyl}-3H-spir()[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure VII as described above, the acylaiion of r-[(6-LhkM(>- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available biphenyl-S-carbon)! chloride gave the title compound. ES-MSm/e(%): 561.4(M+ir). Example 159 l'-[(6-Chloro-l-pyridin-2-yl-lH-indoI-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4 - piperidin]-3-one To a solution of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benz()ruran-l.4'-piperidin]-3-one (prepared according to example 16 above) in dry DMF was added Nail (1 eq) and the reaction mixture stirred at room temperature for 30 min and then treated with 2-fluoropyridine (1.5 eq) and heated at 140 °C under microwave irradiation lor 15 min. Purification by preparative HPLC gave the desired product in 38% yield. ES-MS m/e (%): 458.1(M+H"'). Example 160 l'-[(6-Chloro-l-pyridin-2-yl-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro|2- benzofuran-l,4'-piperidin]-3-one To a solution of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-bcn/t)ruraii^ l,4'-piperidin]-3-one (prepared according to example 19) in dry DMF was added Nal I (1 eq) and the reaction mixture stirred at room temperature for 30 min and then Ircaicd wiili 2-fluoropyridine (1.5 eq) and heated at 140 °C under microwave irradiation for 15 min. Purification by preparative HPLC gave the desired product in 36% yield. ES-MS m/e (%): 476.0(M+H^). Example 161 l'-({6-Chloro-l-[(2-methylpyridin-4-yl)methyl]-lH-indol-3-yl}carbonyl)-5-tlu()r(>- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of ['-[(^-cl^loio-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one (prepared according to example 19) with 4-chloromethyl-2-methyl-pyridine (described in W'i) 2006023707) gave the title compound. Following the general procedure III as described above, the alkylation of r-[(6-chl()i()-lH-indol-3.-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidinJ-3-onc (prepared according to example 19 above) with commerC1-6ally available 2-bromo-l-pyridin-2 ylethanonegave the title compound. ES-MS m/e (%): 518.4(M+H^). Example 170 l'-({6-Chloro-l-[2-(5-methyl-2-phenyl-l,3-oxazol-4-yl)-2-oxoethyl]-lHindol-3-yI}carbonyI)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-f(6-chk)r(t-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-onc (prepared according to example 19) with 2-bromo-l-(5-methyl-2-phenyl-oxa2ol-4-yl)-edian(MK (described in Journal of MediC1-6nal Chemistry (1992), 35(14), 2617-26) gave ihc iiilc compound. ES-MS m/e (%): 598.4(M+H0. Example 171 l'-{[6-Chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro|2- benzofuran-l,4'-piperidin]-3-one a^ Methanesulfonic aC1-6d pyridin-3-vlmethvl ester To a mixture of 2-(hydroxymethyl)pyridine , DMAP and NEt3 was slowly added MsC'l ai 0 °C and the reaction mixture was stirred at room temperature for Ih. The reaC1-6ion mixture was extracted with water and dichloromethane The organic phase was dried on Na2S04, filtered and the solvent was evaporated. Silica gel column chromalographx (dichloromethane / MeOH 99:1) gave the title compound in 52% yield. ES-MS m/e (%): 188.1 (M+H^). b) r"{[6-chloro-l-(pvridin-2-ylmethvlVlH-indol-3-vl]carbonvl}-5-fluoro-3H-spiro|2-benzofuran-l,4'"piperidin]-3-one Following the general procedure III as described above, the alkylation of l'-[(6-chl()ro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with methanesulfonic aC1-6d pyridin-2-ylmethyl ester (described in WO 9955318) gave the desired product in 29% yield; ES-MS m/e (%): 490.0(M+H^). Example 172 l'-{[6-Chloro-l-(pyridin-3-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spir(>[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-|((->-chl{)r(> lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prcparccJ according to example 16) with commerC1-6ally available 3-bromomcthyl-pyridinc yavc ihc title compound. ES-MS m/e (%): 472.1(M+H^). Example 173 l*-{[6-ChIoro-l-(pyra2in-2-ylmethyl)-lH-indoI-3-yl]carbonyl}-5-fluoro-3H-spiro|2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-chIo!\)^ lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with methanesulfonic aC1-6d pyrazin-2-ylmelh>i esicr (preparation described in WO 2002064574) gave the title compound. ES-MS m/e (%): 491.0(M+H^). Example 174 l'-{[6-Chloro-l-(pyrimidin-5-ylinethyl)-lH-indol-3"yl]carbonyl}-5-fluoro-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one a^ Methanesulfonic aC1-6d pyrimidin-5-vlmethvl ester To a mixture of pyrimidin-5-yl-methanol, DMAP and NEt3 was slowly added MsCl ai (i °C and the reaction mixture was stirred at room temperature for 3h. The reaction mixuirc was extracted with water and dichloromethane. The organic phase was dried on Na_SO^-filtered and the solvent was evaporated. Silica gel column chromatography (Eih\l acetate/hexane 1:1) gave the title compound in 40% yield. b) r-{[6-Chloro-l-rpvrimidin-5-vlmethvlVlH-indol-3-yl]carbonvl}-5-f]uoro-3H-spiro[2-benzofuran-h4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-chk)r(t-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with methanesulfonic aC1-6d pyrimidin-5-ylmethyl ester iia\ e ihe title compound. ES-MS m/e (%): 491.0(M+H^). Example 175 3-{6-Chloro-3-[(5-fIuoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indol-l-yl}propanenitrile Following the general procedure III as described above, the alkylalion of r-|(6-chlt)i(i lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-()nc (prepared according to example 19) with commerC1-6ally available S-bromo-propioniirilc gave ihe title compound. ES-MS m/e (%): 452.0(M+H^). Example 176 l'-[(7-Chloro-l-oxo-l,2,3,4-tetrahydropyrazino[l,2-a]indol-10-yI)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l54'-piperidin]-3-one a) 6-Chloro-li/-indole-2,3-dicarboxylic aC1-6d 2-ethvl ester To a solution of commerC1-6ally available 6-chloro-3-formyl-l//-indole-2-carbc)xy!ic ;tC1-6J ethyl ester in t-BuOH and 2-methyl-2-butene (50 eq) was added 9.2 ecj NyC1-6O:^ (^) CL[) and aq. NaH2P04 (7 eq) and stirred 12h at room temperature. After conceniraiion ilic mixture was dissolved in H2O and adjusted to pH7 and then extracted with EfOAc: partial concentration of the organic phase preC1-6pitated the product in 52% \'ield. b^ Ethyl 6-chloro-3-[r5-fluoro-3-oxO"l'H,3H-spiro[2-benzofuran-1.4'-piperidin |-1 '-vHcarbonyl] - lH-indole-2-carboxvlate Following the general procedure I as described above, the acylation ofr-[(6-chiorc* !M-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-onc (prepared according to example 19) with 6-chloro-l//-indole-2,3-dicarboxylic aC1-6d 2-ctb\! csicr gave the title compound.. ES-MS m/e (%): 471.0 (M+H^). c)6-Chloro-3-[(5-fluoro-3-oxo-rH3H-spiro[2-benzofuran-1.4'-piperidin]-r-vHcarbonvl] - lH-indole-2-carboxvlic aC1-6d A solution of the ethyl 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-1.4' piperidin]-r-yl)carbonyl]-lH-indole-2-carboxylate in EtOH was treated with 2 cq. oi acj. IN LiOH at 80 °C for 12h, then concentrated and dissolved in IN HCl and cxiraC1-6cd wuh dichloromethane. Evaporation of the solvent gave the title compound in 72% yield. d) 6-Chloro-N-r2-chlorQethvlV3-[r5-fluoro-3-oxo-rH.3H-spiro[2-benzofuran-1.4'- piperidin]-r-yl)carbonvl]-lH-indole-2-carboxamide To a stirred solution of 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzoturan-i-4-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d in dichloromethane were added EDC, HOBt, NEt3 and 2-chloroethylamine hydrochloride. The reaction mixture was stirred at room temperature for 2 days. The reaction mixture was poured onto waier and extracted with dichloromethane. The combined organic phases were dried over Na SO; and the solvent was evaporated. Column chromatography (ethyl acetate/hexane 1:1) ga\ e the desired compound in 59% yield. MS m/e (%): 504.0 (M+H^. e) r-[(^7-Chloro-l-oxO"l,2,3,4-tetrahvdropvra2ino[l,2-a]indol-10-vncarbonv]|o-nu()r()- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one A solution of the 6-chloro-N-(2-chloroethyl)-3-[(5-fluoro-3-oxo-rH,3H-spin)| 2 benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxamide in dry DMF was treated with NaH (1 eq) and stirred for Ih at room temperature, then trealcd with a further portion of NaH (1 eq) and stitted for 2h at room temperature. Dilution wiih water and extraction with EtOAc followed by washing with aq. NH4C1-6 gave the crude product which was purified by silica gel chromatography (dichloromethane/MeOH 98:2) to gixe 42% yield of the desired product. ES-MS m/e (%): 468.3 (M+H^. Example 177 l'-({l-[(4-BenzyImorpholin-2-yI)methyl]-6-chloro-lH-indol-3"yl}carbonyl)-5-flu()r(»- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-ch]()r()-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidinJ-3-one (prepared according to example 19 above) with commerC1-6ally available 4-bcn/\l-2-(chloromethyl)morpholine gave the title compound. ES-MS m/e (%): 588.2(M+H0. Example 178 l'-({6-Chloro-l-[(l,4-dibenzylpjperazin-2-yl)methyl]4H-indol-3-yl}carhonyll-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-|(6-chl()r(*-lH-indo]-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with l,4-dibenzyl-2-chloromethyl-piperazine (described in Journal of MediC1-6nal Chemistry 1999, 42(9), 1587-1603) gave the title compound. ES-MS m/e (%): 677.3(M+H^). Example 179 l'-({6-Chloro-l-[(5-methyIisoxa2ol-3-yI)methyl]-lH-indol-3-yl}carbonyl)-5-fluor()- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-((6chliM(^-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prc[)arcd according to example 19) with methanesulfonic aC1-6d 5-methyl-isoxazol-3-ylmclhyl csiC1-6 (described in WO 2004092172) gave the title compound. ES-MSm/e(%): 494.1(M+H0. Example 180 l'-{[6-Chloro-l-(pyridin-2-yimethyl)-lH-indoI-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r~[(^'X'tilt)ic>- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16 above) with methanesulfonic aC1-6d pyridin-2-ylmcthyl csicr (described in WO 9955318) gave the title compound. ES-MSm/e(%): 472.1(M+H^). Example 181 6-Chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin] 1-yI)carbonyl]-N-methyl-lH-indole-2-carboxamide A suspension of the 6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-bcnzoruTan-1.4-^ piperidin]-r-yl)carbonyl]-lH-indole-2-carboxylic aC1-6d in dichloromethanc was ucaicd with EDC (1.2 eq), HOBt (1.2 eq) and EtsN (1.2 eq) and the solution stirred ai rocmi temperature for 15 min. Methylamine (1 eq) was then added and the reaction mixiuiL stirred at room temperature for 16h. Purification by preparative HPLC yielded [1R desired product. ES-MSm/e(%): 456.1(M+H0. Example 182 l'-({6-ChIoro-l-[(5-cyclopropyI-2-methyI-l,3-oxazol-4-yI)methyl]-lH-indol-3-yl}carbonyI)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one a) 2"Acetvlamino-2-cvclopropanecarbonvl-malonic aC1-6d diethyl ester To a solution of 6 eq KOt-Bu in THF at room temperature was added 6 cq 2-acetylamino-malonic aC1-6d diethyl ester and after 5 min 1 eq cyclopropanc-carbonylchloride. After 15min, the mixture was concentrated and parlitioned between EtOAc and H2O. The organic layer was concentrated to give the desired product in (>(f^ ^ yield. ES-MS m/e (%): 286.2 (M+H^. b^ 5-Cvclopropvl-2-methvl-oxazole-4"Carboxvlic aC1-6d ethyl ester 2-Acetylamino-2-cyclopropanecarbonyl-malonic aC1-6d diethyl ester in DMSO was ircaiecl with 2 eq H2O and stirred at room temperature for 6h then extracted with EbO u> gi\ e after concentration the title compound in 34% yield. c) (5-Cvclopropvl-2-methvl-oxazol-4-ylVmethanol A solution of 5-cyclopropyl-2-methyl-oxazole-4-carboxylic aC1-6d ethyl ester in Ei^O at (i °C was treated sequentially with (2 x 2.3 eq) LiBH4 and stirred for Ih. 10 eq of MeOH were then added and the solution stirred for 4h at room temperature. Sequential addition of aq NH4C1-6 (H2 evolution) and then Na2C03/NaCl gave a mixture which was exliaC1-6cd with EtOAc to give after concentration the title compound in 16% yield. ES-MS m/e (%): 154.1 (M+H^. d^ l'-(;{6-Chloro-l-[(5-cyclopropvl-2-methvl-1.3-oxazol-4-ynmethvl]-lH-indol-3-^ yl}carbonvlV5-fluoro-3H-spiro[2-benzofuran-L4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6~clil(>r()~ lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with methanesulfonic aC1-6d 5-cyclopropyl-2-melhyl-()xa/,t)l-4 ylmethyl ester (prepared by mesylation of (5-cyclopropyl-2-methyI-oxaz()l-4-\ 1)-methanol) gave the title compound. ES-MS m/e (%): 534.2(M+H^). Example 183 l'-({6-Chloro-l-[(l-methyMH-imidazol-5-yl)methyI]-lH-indol-3-yl}carbonyl).5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]"3-one Following the general procedure III as described above, the alkylation of r-[(6-chUM-o-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with methanesulfonic aC1-6d 3-methyl-3//-imida2ol-4-yinieih\ i ester (prepared by mesylation of the commerC1-6ally available (3-methyl-3//-imida/(»l-4-yl)-methanol) gave the title compound. ES-MSm/e(%): 493.1(M+H'). Example 184 l'-({6-Chloro-l-[(3-methylisoxazol-5-yl)methyl]-lH-indol-3-yl}carbonyI)-5-nu()n)- 3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-((6'Chl{ir{» lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]oK)ne (prcpaiccl according to example 19) with methanesulfonic aC1-6d 3-methyl-isoxazol-5-ylmc[iiyl csicr (described in Heterocycles, 23(3), 571-83; 1985) gave the title compound. ES-MSm/e(%): 494.1(M+H^). Example 185 l'.({6-ChIoro-l-[(l,5-dimethyl-lH-pyrazol-3-yl)methyl]-lH-indol3-yl}carbon>l)-5 fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-|(f>-chl()ic)-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-onc (prepared according to example 19) with methanesulfonic aC1-6d l,5-dimethyl-l/y~pyrazc)l-3-ylmethyl ester (prepared by mesylation of commerC1-6ally available methanesulfonic aC1-6d l,5-dimethyl-]i/-pyra2ol-3-ylmethyl ester) gave the title compound. ES-MS m/e (%): 507.2(M+H^). Example 186 l'-({6-Chloro-l-[(3,5-dimethylisoxazol-4-yl)methyI]-lH-lndol-3-yl}carbonyl)o-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(f>-chlori)-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-onc (prepared according to example 19 above) with methanesulfonic aC1-6d 3,5-dimelhy]-isoxaz(il-4 ylmethyl ester (prepared by mesylation of the commerC1-6ally available l,5-dimcth)l-l//-pyrazol-3-yl)-methanoI) gave the title compound. ES-MS m/e (%): 508.2(M+H0. Example 187 l'-({6-Chloro-l-[(2,5-dimethyl-l,3-oxazol-4-yI)methyl]-lH-indol-3-yl}carbonylt^ fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-|(6-chi()R> lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidinj-3-onc (prepared according to example 19 above) with methanesulfonic aC1-6d 2,5-dimcthyl-c)xa/.(>l-4-^ ylmethyl ester (prepared by mesylation of (2,5-dimethyl-oxazol-4-yI)-mC1-6han()L described in Organic Letters (1999), 1(1), 87-90) gave the title compound. ES-MS m/e (%): 508.1(M+H0. Example 188 l'-({6-Chloro-l-[(3-fluorooxetan-3-yl)methyl]-lH-indol-3-yI}carbonyl)-5-fluor(>-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of l'-|(6-chk)ni-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with 3-bromomethyl-3-fluoro-oxetane (described m US2005215599) gave the title compound. ES-MSm/e(%): 487.1(M+H"'). Example 189 l'-({6-Chloro-l-[(3-fluorooxetan-3-yI)methyl]-lH-indol-3-yl}carbonyl)-3H-spir()|2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of l'-[(6-chl()ro- lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one (prepared according to example 16 above) with 3-bromomethyl-3-fluoro-oxetanc (described in US2005215599) gave the title compound. ES-MS m/e (%): 469.2(M+H0. Example 190 l'-[(6-Chloro-l-{[l-(methoxymethyl)cyclopropyl]methyl}-lH-indol-3-yI)carb()n\ij-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of ]'-|((^-chI(>r(>-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-onc (prC1-6iarcd according to example 19) with l-bromomethyl-l-methoxymethyl-cyck^propanL (described in WO 2001032633) gave the title compound. ES-MS m/e (%): 497.5(M+H0. Example 191 [l-({6-ChIoro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin|-r-yl)carbonyl]-lH-indol-l-yl}methyl)cyclopropyI]acetonitrlle Following the general procedure III as described above, the alkylation of r-|(6-chlort>-lH-indol-3-yl)carbonyl]-5-fluoro~3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with l-bromomethyl-cyclopropanecarbonitrile (described \\\ EP 148004) gave the title compound. ES-MS m/e (%): 492.5(M+H^). Example 192 l'-[(6-Chloro-l-{[l-(methoxymethyI)cyclopropyl]methyl}-lH-indol-3-yl)carboiivl|- 3H-spiro[2-ben2ofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-chloro' lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16 above) with l-bromomethyl-l-methoxymethyl-cyclopropane (prepared as described in WO 2001032633) gave the title compound. ES-MS m/e (%): 479.5(M+H^). Example 193 [l-({6-Chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuraii-l,4'-piperidin]-l'-yl)carbonyij- lH-indol-l-yl}methyl)cyclopropyl]acetonitrile Following the general procedure III as described above^ the alkylation of l'-|(6-chl(>ro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with 1-bromomethyl-l-methoxymethyl-cyclopropanc (prepared by WO 2001032633) gave the title compound. ES-MS m/e (%): 474.5(M+H^). Example 194 6-Chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidinJ-l'-yl)carbonyl]-N-[2-(methylamino)ethyl]-lH-indole-2-carboxamide hydrochloride A solution of tert-butyl {2-[({6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-ben/t>rurarv l,4'-piperidin]-r-yl)carbonyl]-lH-indol-2-yl}carbonyl)amino]ethyl}methylcarhamalc was treated with 4 eq of HCl in dioxane and stirred at room temperature lor 3h ihen treated with a further portion of 4 eq of HCl in dioxane. The solution was stirred at loom temperature for 16h and evaporated to give the product in 58% yield. ES-MSm/e(%): 511.2(M+H^). Example 195 l'-({6-Chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethy!]-lH-indol-3-y!}carbonv!)-5 fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one hydrochloride Following the general procedure III as described above, the alkylation oi J'-|(6-chlor(> lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-onc (prepared according to example 19) with 4-(2-bromo-ethyl)-tetrahydro-pyran (described in US 2004220214) gave the title compound. ES-MS m/e (%): 511.2 (M+H^). Example 196 l'-({6-Chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-ben2ofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with 4-(2-bromo-ethyl)-tetrahydro-pyran (described in US 2004220214) gave the tide compound. ES-MS m/e (%): 493.2 (M+H^). Example 197 tert-Butyl2-({6-chIoro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yI}methyl)morpholine-4-carboxylate Following the general procedure III as described above, the alkylation of l'-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with 2-chloromethyl-morpholine-4-carboxylic aC1-6d tert-huiyl ester (described in WO 2006020415) gave the title compound. ES-MS m/e (%): SSCOCM+H*"). Example 198 l'-{[6-Chloro-l-(morphoIin-2-yImethyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one hydrochloride tert-Butyl 2-({6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r- yl)carbonyl]-lH-indol-l-yl}methyl)morpholine-4-carboxylate was dissolved in a solution of HCl (5 eq) in dioxane and stirred at room temperature for 5h. A further portion of HCl (5 eq) in dioxane was added and the solution stirred for an additional 5h at room temperature. Evaporation gave the desired product in 96% yield.ES-MS m/e (%): 480.2 (M+H^. Example 199 tert-Butyl 2-({6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}methyl)morphoIine-4-carboxylate Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yI)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with 2-chloromethyl-morpholine-4-carboxylic aC1-6d tert-butyl ester (described in WO 2006020415) gave the title compound. ES-MS m/e (%): 598.2(M+H^). Example 200 l'-{[6-Chloro-l-(morphoIin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one dihydrochloride tert-Butyl 2-({6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}methyl)morpholine-4-carboxylate was dissolved in a solution of HCl (5 eq) in dioxane and stirred at room temperature for 5h. A further portion of HCl (5 eq) in dioxane was added and the solution stirred for an additional 5h at room temperature. Evaporation gave the desired product in quantitative yield.ES-MS m/e(%): 498.1 (M+H^). Example 201 l'-{[l-(3,5-Difluorobenzyl)-lH-indol-3-yI]carbonyl}-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 19) with commerC1-6ally available 3,5-difluorobenzyl chloride gave the title compound. ES-MS m/e (%): 491.5(M+H^). Example 202 l'-{[l-(3,5-DifluorobenzyI)-lH-indoI-3-yl]carbonyl}-3H-spiro[2-benzofuraii-l,4'- piperidin]-3-one Following the general procedure III as described above, the alkylation of l'-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 3,5-difluoroben2yl chloride gave the title compound. ES-MS m/e (%): 473.5(M+H^). Example 203 N,N-DiethyI.2-{3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'- yl)carbonyI]-lH-indol-l-yl}acetamide Following the general procedure III as described above, the alkylation of r-[(6-chloro- lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one (prepared according to example 16) with commerC1-6ally available 2-chloro-N-N-diethyl-acetamide gave the title compound. ES-MS m/e (%): 460.6(M+H^). Examples of compounds of formula (I-d) Example 204 l'-{[6-Chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2. benzofuraii-l,4'-piperidine] Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commerC1-6ally available 2-chloro-l-piperidin-1-yl-ethanone as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 492.1 (M+H^). Example 205 l-{[6-Chloro-l-(2-morpholin-4-yl-2-oxoethyl)-lH-indol-3-yl]carbonyI}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commerC1-6ally available 2-Chloro-l-morpholin-4-yl-ethanone as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 494.1 (M+H^). Example 206 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyI)-lH-indol- l-yl]-N,N-dimethylacetamide Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commerC1-6ally available 2-chloro-N,N-dimethyl-acetamide as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 452.0 (M+H^). Example 207 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indoI- l-yl]-N,N-diethylacetamide Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commercially available 2-chloro-N,N-diethyl-acetamide as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 480.1 (M+H^). Example 208 l'-{[6-Chloro-l-(piperidin-l-ylcarbonyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commercially available piperidine-1-carbonyl chloride as electrophile, the title compound was obtained as a white powder. ES-MS m/e (%): 478.0 (M+H^. Example 209 tert-Butyl [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)- lH-indol-l-yl]acetate Following the general procedure V as described hereinabove, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commercially available chloro-acetic acid tert-butyl ester as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 481.3 (M+H^). Example 210 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yIcarbonyl)-lH-indol- l-yl]-N,N-dimethylethanamine Following the general procedure V as described hereinabove, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commercially available (2-chloro-ethyl)-dimethyl-amine as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 438.4 (M+H^). Example 211 l'-{[6-Chloro-l-(2-oxo-2-piperazin-l-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commercially available 4-(2-chloro-acetyl)-piperazine-l-carboxylic acid tert-butyl ester as electrophile, the title compound was obtained as a white solid after removal of the Boc protecting group under standard conditions (TFA /dichloromethane, room temperature). ES-MS m/e (%): 493.1 (M+H^). Example 212 l'-({6-ChIoro-l-[2-(4-methylpiperazin-l-yl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)- 3H-spiro[2-benzofuraii-l,4'-piperidine] Following the general procedure V as described hereinabove, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine](the preparation of which have been described in example 69) with commercially available 2-chloro-l-(4-methyl-piperazin-l-yl)-ethanone as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 507.4 (M+H^. Example 213 2-[6-Chloro-5-methyl-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyI)- lH-indol-l-yl]-N,N-dimethyIacetamide Amide coupling according to general procedure I described hereinabove: - Amine: Spiro[isobenzofuran-l(3H),4'-piperidine] pepared as described in J. Org. Chem. 1976, 41, 2628, - Acid: 6-Chloro-l-dimethylcarbamoylmethyl-5-methyl-lH-indole-3-carboxylic acid, ES-MS m/e (%): 466.3 (M+H^). Example 214 l'-{[6-ChIoro-l-(3-fluorobenzoyl)-lH-indoI-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine Following the general procedure VII as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 489.4(M+H0. Example 215 l'-{[6-Chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l54'-piperidine Following the general procedure VII as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 2-fluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 489.4(M+tr). Example 216 l'-{[6-Chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine Following the general procedure VII as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3,5-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 507.4(M+H0. Example 217 l'-{[6-Chloro-l-(2,3-difluorobenzoyl)-lH-indol-3-yI]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine Following the general procedure VII as described above, the acylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 2,3-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 507.4(M+H0. Example 218 l'-({6-Chloro-l-[(3,5-difluorophenyl)sulfonyl]-lH-indoI-3-yl}carbonyI)-3H-spiro[2- benzofuran-l,4'-piperidine Following the general procedure VII as described above, the sulphonylation of r-[(5- chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3,5-difluorobenzenesulfonyl chloride gave the title compound. ES-MS m/e (%): 543.3(M+H0. Example 219 r-{[6-Chloro-l-(3,5-difluorobenzyl)-lH-indoI-3-yl]carbonyl}-3H.spiro[2- benzofuran-l,4'-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3,5-difluorobenzyl chloride gave the title compound. ES-MS m/e (%): 493.4(M+H*'). Example 220 l'-{[6-ChIoro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3-fluorobenzyl chloride gave the title compound. ES-MS m/e (%): 475.4(M+Er). Example 221 l'-{[l-(Biphenyl-3-ylcarbonyI)-6-chloro-lH-indoI-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine Following the general procedure VII as described above, the acylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available biphenyl>3-carbonyl chloride gave the title compound. ES-MS m/e (%): 547.4(M+H^). Example 222 l'.{[6-Chloro-l-(3,5-difluorophenyl)-lH-indol-3.yI]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine Following the general procedure VI as described above, the arylation of r-[(6-chloro-lH-indol-3-yI)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3,5-difluorophenylboronic acid gave the title compound. ES-MS m/e (%): 478.9(M+H0. l'-{[6-Chloro-l-(3-fluorophenyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran- l,4'-piperidine Following the general procedure VI as described above, the arylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3-fluorophenylboronic acid gave the title compound. ES-MS m/e (%): 461.1(M+H*). Example 224 2-[6-ChIoro-3-(l'H,3H-spiro[2-benzofuran-l,4*-piperidin]-l'-ylcarbonyI)-lH-indoI- l-yl]-l-(2-fluorophenyl)ethanone Following the general procedure III as described above, the alkylation of r-[(6-ch]oro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 2-bromo-l-(2-fluoro-phenyl)-ethanonegave the title compound. ES-MS m/e (%): 503.4(M+H'). Example 225 l'-[(l-Biphenyl-2-yI-6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidine Following the general procedure VI as described above, the arylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 2-biphenylboronic acid gave the title compound. ES-MS m/e (%): 519.3(M+H^). Example 226 l'-[(l-Biphenyl-2-yl-6-chloro-lH-indol-3-yl)carbonyI]-3H-spiro[2-benzofuran-l,4'- piperidine Following the general procedure VI as described above, the arylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4-piperidine] (prepared according to example 69) with commercially available 3-biphenylboronic acid gave the title compound. ES-MSm/e(%): 519.3(M+H^). Example 227 l'-[(6-Chloro-l-pyridin-2-yI-lH-indol-3-yI)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidine To a solution of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) in dry DMF was added NaH (1 eq) and the reaction mixture stirred at room temperature for 30 minand then treated with 2-fluoropyridine (1.5 eq) and heated at 140 °C under microwave irradiation for 15 min. Purification by preparative HPLC gave the desired product in 24% yield. ES-MS m/e (%): 444.1(M+H"'). Example 228 l'-{[6-ChIoro-l-(pyridin-4-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 4-bromomethyl-pyridine gave the title compound. ES-MS m/e (%): 458.4(M+H^). Example 229 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yI]-l-pyridin-2-ylethanone Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69 above) with commercially available 2-bromo-l-pyridin-2-ylethanone gave the title compound. ES-MS m/e (%): 486.4(M+H^). Example 230 l'-{[6-Chloro-l-(pyridin-3-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-1,4' -piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 3-bromomethyl-pyridine gave the title compound. ES-MS m/e (%): 458.4(M+H^). Example 231 l'-{[6-Chloro-l-(pyridin-2-ylmethyI).lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chl6ro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid pyridiTi-2-ylmethyl ester (described in WO 9955318) gave the title compound. ES-MS m/e (%): 458.3(M+H^). Example 232 l'-({l-[(4-BenzylmorphoIin-2-yl)methyl]-6-chloro-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuraii-l,4*-piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 4-benzyl-2-(chloromethyl)morpholine gave the title compound. ES-MS m/e (%): 556.3(M+H^). Example 233 l'-({6-Chloro-l-[(l,4-dibenzylpiperazin-2-yl)methyI]-lH-indol-3-yI}carbonyI)-3H- spiro[2-benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69 above) with l,4-dibenzyl-2-chloromethyl-piperaziiie (described in Journal of Medicinal Chemistry (1999), 42(9), 1587-1603) gave the title compound. ES-MS m/e (%): 645.3(M+H0. Example 234 l'-{[6-Chloro-l-(pyra2in-2-yImethyI)-lH-indol-3-yI]carbonyI}-3H-spiro[2- benzofuran-l,4'-'piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'-piperidine] (prepared according to example 69 above) with methanesulfonic acid pyrazin-2-ylmethyl ester (preparation described in WO 2002064574) gave the title compound. ES-MS m/e (%): 459.3(M+H^). Example 235 l'-{[6-Chloro-l-(pyrimidin-5-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spirol2- benzofuran-l54'-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloTO-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid pyrimidin-5-ylmethyl ester (preparation described herein) gave the title compound. ES-MSm/e(%): 459.3(M+H^). Example 236 l'-({6-Chloro-l-[(5-methylisoxazol-3-yl)methyl]-lH-indol-3-yI}carbonyI)-3H- spiro[2-benzofuran-l,4*-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid 5-methyI-isoxazol-3-ylmethyl ester (described in WO 2004092172) gave the title compound. ES-MS m/e (%): 462.2(M+H0. Example 237 l-({6-Chloro-l-[(5-cyclopropyl-2-methyl-l,3-oxazoI-4-yl)inethyl]-lH-indol-3-yl}carbonyI)-3H-spiro[2-benzofuran-l,4'-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69 above) with methanesulfonic acid 5-cyclopropyl-2-methyl-oxazol-4-ylmethyl ester (prepared herein) gave the title compound. ES-MS m/e (%): 502.2(M+H0. Example 238 l'-({6-Chloro-l-[(l-methyl-lH-imidazol-5-yI)methyl]-lH-indol-3-yI}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid 3-methyl-3//-imida2ol-4-ylmethyl ester (prepared by mesylation of the commercially available (3-methyl-3//-imidazol-4-yl)-methanol) gave the title compound. ES-MS m/e (%): 461.2(M+H0. Example 239 l'-({6-Chloro-l-[(3-methylisoxazol-5-yl)methyi]-lH-indol-3-yl}carbonyI)-3H- spiro[2-benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid 3-methyl-isoxazol-5-ylmethyl ester (described in Heterocycles, 23(3), 571-83; 1985) gave the title compound. ES-MS m/e (%): 462.2(M+H^). Example 240 l'-({6-Chloro-l-[(l,5-dimethyI-lH-pyrazol-3-yl)methyl]-lH-indol-3-yl}carbonyI)- 3H-spiro[2-benzofuran-l,4'-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid l,5-dimethyl-l//-pyrazol-3-ylmethyl ester (prepared by mesylation of commercially available methanesulfonic acid 1,5-dimethyl-l//-pyrazoI-3-ylmethyl ester) gave the title compound. ES-MS m/e (%): 475.2(M+H^). Example 241 l'-({6-Chloro-l-[(355-dimethyIisoxazol-4-yI)methyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4*-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid 3,5-dimethyl-isoxazol-4-ylmethyl ester (prepared by mesylation of the commercially available l,5-dimethyl-li/-pyrazol-3-yl)-methanol) gave the title compound. ES-MS m/e (%): 476.2(M+H0. Example 242 l'-({6-ChIoro-l-[(2,5-diinethyl-l,3-oxazoI-4-yl)methyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid 2,5-dimethyl-oxa2ol-4-ylmethyl ester (prepared by mesylation of (2,5-dimethyl-oxazol-4-yl)-methanol, described in Organic Letters 1999, 1(1), 87-90) gave the title compound. ES-MS m/e (%): 476.2(M+H^). Example 243 l'-({6-ChIoro-l-[(3-fluorooxetan-3-yI)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with 3-bromomethyl-3-fluoro-oxetane (described in US2005215599) gave the title compound. ES-MS m/e (%): 455.2(M+H^). Example 244 l'-[(6-Chloro-l-{[l-(methoxymethyI)cyclopropyl]methyl}-lH-indol-3-yl)carbonyl]- 3H-spiro[2-benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yI)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with 1-bromomethyl-l-methoxymethyl-cyclopropane (described in WO 2001032633) gave the title compound. ES-MS m/e (%): 465.5(M+H^). Example 245 (l-{[6-ChIoro-3-(l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l'-ylcarbonyI)-^ indol-l-yl]methyl}cyclopropyl)acetonitrile Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with l-bromomethyl-cyclopropanecarbonitrile (described in EP 148004) gave the title compound. ES-MS m/e (%): 460.5(M+H^). Example 246 l'-({6-Chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yl}carbonyI)-3H- spiro[2-benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with 4-(2-bromo-ethyl)-tetrahydro-pyran (described in US 2004220214) gave the title compound. ES-MS m/e (%): 479,5(M-fH^). Example 247 tert-Butyl 2-{[6-chloro-3-(l'H,3H-spiro[2-benzoftiran-l,4'-piperidin]-l'-yIcarbonyl)- lH-indol-l-yl]methyI}morphoIine-4-carboxylate Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with 2-chloromethyl-morpholine-4-carboxylic acid tert-butyl ester (described in WO 2006020415) gave the title compound. ES-MS m/e (%): 5663(M+H^). Example 248 l*-{[6-Chloro-l-(morpholin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofiiran-l,4*-p]per]di]]e] hydrochloride tert-Butyl 2-{[6-chloro-3-(l'H,3H-spiro[2-benzofuran4,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]methyl}morpholine-4-carboxyIate (prepared in example 247 above) was dissolved in a solution of HCl (5 eq) in dioxane and stirred at room temperature for 5h. A further portion of HCl (5 eq) in dioxane was added and the solution stirred for an additional 5h at room temperature. Evaporation gave the desired product in quantitative yield.ES-MS m/e (%): 466.2 (M+H^), Example 249 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuraii-l,4'-piperidin]-l'-yIcarbonyl)-lH-indoI- 1-yl] -N- [2- (dimethy lamino)ethyl]acetamide A solution of [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]acetic acid (prepared by treatment of the sodium salt of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] with bromoacetic acid at room temperature in DMF), EDC (1 eq), HOBt (1 eq) and Et3N (1 eq) were stirred together at room temperature in DMF for 15 min. N,N-Dimethyl-ethane-l,2-diamine (1 eq) was added and the solution stirred at room temperature for 16h. Purification by prep. HPLC gave 37% of product. ES-MS m/e (%): 495.6(M+fr). Example 250 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyi)-lH-indol- l-yl]acetamide A solution of [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]acetic acid (prepared as for 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]-N-[2-(dimethylamino)ethyl]acetamide), 0-(7- azabenzotriazol-l-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (1.05 eq) and EtsN (1.05 eq) were stirred together at room temperature in dry DMF for 15 min. A solution of ammonia (5 eq) in dioxane was added and the solution stirred at room temperature for 16 h. Purification by prep. HPLC gave 31% of product. ES-MS m/e (%): 424.3(M+H"'). Example 251 2-[6-ChIoro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidiii]-l'-yIcarbonyl)-lH-indol- l-yI]-N-[2-(methyIamino)ethyl]acetainide A solution of [6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]acetic acid (prepared by treatment of the sodium salt of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] with bromoacetic acid at room temperature in DMF), 0-(7-azabenzotriazol-l-yl)-N,N,N' ,N' - tetramethyluronium hexafluorophosphate (1.05 eq) and EtaN (1.05 eq) were stirred together at room temperature in dry DMF for 15min. Commercially available N-(2-aminoethyl)-N-methylcarbamic acid tert-butyl ester (1.5 eq) was added and the solution stirred at room temperature for 2h, then a solution of HCl (15 eq) in dioxane was added and the solution stirred for 2h. Evaporation and purification by prep. HPLC gave 37% of product. ES-MS m/e (%): 481.3(M+H'). Example 252 N-(2-Aminoethyl)-2-[6-chIoro-3-(l'H,3H-spiro[2-benzofuran-l,4-piperidin].^ yIcarbonyI)-lH-indol-l-yl]acetainide A solution of [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]acetic acid (prepared by treatment of the sodium salt of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] with bromoacetic acid at room temperature in DMF), 0-(7-azabenzotriazol-1 -y 1)-N,N,N' ,N' - tetramethyluronium hexafluorophosphate (1.05 eq) and EtsN (1.05 eq) were stirred together at room temperature in dry DMF for 15min. Commercially available N-(tert-Butoxycarbonyl)-l,2-diaminoethane (1.5 eq) was added and the solution stirred at room temperature for 2h, then a solution of HCl (15 eq) in dioxane was added and the solution stirred for 2h, Evaporation and purification by prep. HPLC gave 39% of product. ES-MS m/e (%): 467.4(M+H0. Example 253 2-[6-Chloro-3-(lH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yl]ethanamine Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69 above) with commercially available 2-chloro-ethylamine gave the title compound in 11% yield. ES-MS m/e (%): 410.2(M+H^). Example 254 2-[6-Chloro-3-(l*H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l'-ylcarbonyI)-lH-indoI- l-yI]-N-methylethanamlne Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available (2-chloro-ethyl)-methyl-amine gave the title compound in 42% yield. ES-MS m/e (%): 424.2(M+H^). Example 255 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]4'-ylcarbonyl)-lH-ind^^ l-yl]-N-methylacetamide Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 2-chloro-A^-methyl-acetamide gave the title compound in 19% yield. ES-MS m/e (%): 438.2(M+H^). Example 256 l'-{[6-Chloro-l-(2-morpholin-4-ylethyl)-lH-indol-3-yl]carbonyl}.3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 4-(2-chloro-ethyl)-morpholine gave the title compound in 50% yield. ES-MS m/e (%): 480.5(M+H^). Example 257 l'-{[6-Chloro-l-(3-morphoIin-4-ylpropyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 4-(3-chloro-propyl)-morpholine gave the title compound in 52% yield. ES-MS m/e (%): 494.6(M+H^). Example 258 l'-{[6-Chloro-l-(oxiran-2-ylmethyl)-lH-indol-3-yI]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 2-bromomethyl-oxirane gave the title compound in 47% yield. ES-MS m/e (%): 423.4(M+H^). Example 259 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yl]ethanol Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-ben2ofuran-l,4'-piperidine] (prepared according to example 69) with commercially available 2-chloro-ethanol gave the title compound in 47% yield. ES-MSm/e(%): 411.4(M+H^). Example 260 l-({6-Chloro-l-[(2-methylpyridin-4-yI)methyl]-lH-indol-3-yI}carbonyI)-3H-splro benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with 4-chloromethyl-2-methyl-pyridine (described in WO 2006023707) gave the title compound in 56% yield. ES-MS m/e (%): 472.2(M+H^). Example 261 l'-({6-Chloro-l-[(3S)-piperidin-3-ylinethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4*-piper]dine] A solution of the l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) in dry DMF was treated with NaH (1.1 eq) and stirred for 10 min at room temperature, then treated with (S)-3-methanesulfonyloxymethyl-piperidine-l-carboxylic acid tert-hniyl ester (1.1 eq) (JP 2001278872) and stined at room temperature for 16h then 70° for 4h. Concentration and treatment with excess HCl in dioxane gave after purification by preparative HPLC the desired product in 39% yield. ES-MS m/e (%): 464.2(M+H"'). Example 262 2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yl]-N-hydroxyethanamine A solution of the [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]acetaldehyde in MeOH was treated with KOAc (1.5 eq) and hydroxylamine hydrochloride (1.2 eq) and stirred for 1 h at room temperature, then treated with NaCNBHs (1.1 eq) and stirred at room temperature for 5 h. Concentration and purification by preparative HPLC the desired product in 19% yield. ES-MS m/e (%): 426.1(M+ir). Example 263 l'-{[6-Chloro-l-(tetrahydro-2H-pyran-4-ylmethyl)-lH-indol-3-yl]carbonyl}-3H- spiro[2-benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of l'-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with commercially available methanesulfonic acid 2-(tetrahydro-pyran-4-yl)-ethyl ester (described in US 2004220214) gave the title compound in 55% yield. ES-MS m/e (%): 465.2(M+H0. Example 264 l'K{6-Chloro-l-[(l-methylpyiToIidin-3-yI)methyl]-lH-indol-3-yI}carbonyI)-3H- spiro[2-benzofuran-l,4'-piperidine] A solution of r-{[6-chloro-l-(pyrrolidin-3-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]in MeOH was treated with aq. H2CO (1.5 eq), AcOH (1.1 eq) and stirred for 15 min at room temperature, then treated with NaCNBH3 (1.1 eq) and stirred at room temperature for Ih. Concentration and purification by preparative HPLC gave the desired product. ES-MS m/e (%): 464.2(M+H^). Example 265 l'-[(6-Chloro-l-{[(3S)-l-methyIpiperidin-3-yI]methyl}-lH-indol-3-yl)carbonyl]-3H- spiro[2-benzofuran-l,4'-piperidine] A solution of r-({6-chloro-l-[(3S)-piperidin-3-ylmethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine] in MeOH was treated with aq. H2CO (1.5 eq), AcOH (1.1 eq) and stirred for 15 minat room temperature, then treated with NaCNBH3 (LI eq) and stirred at room temperature for Ih. Concentration and purification by preparative HPLC the desired product. ES-MS m/e (%): 478.2(M+H^). Example 266 l'-{[6-Chloro-l-(pyrrolidin-3-yIinethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine] Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid pyrrolidin-3-ylmethyl ester (described in WO 9742189) gave the title compound. ES-MS m/e (%): 450.2(M+H^). Example 267 l'-({6-aiIoro-l-[(2S)-pyiTolidin-2-ylmethyl]-lH-indol-3-yl}carbonyI)-3H-spi^^ benzofuran-l,4'-piperidine Following the general procedure III as described above, the alkylation of r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine] (prepared according to example 69) with methanesulfonic acid (S)-l-pyrrolidin-2-ylniethyl ester (described in Tetrahedron: Asymmetry (1997), 8(13), 2209-2213) gave the title compound. ES-MS m/e (%): 450.2(M+H0. Example 268 l'-[(6-Chloro-l-{[(2S)-l-methyIpyrrolidin-2-yl]methyI}-lH.indol-3-yl)carbonyl]-3H- spiro[2-benzofuran-l,4'-piperidine l'-({6-Chloro-l-[(2S)-pyrrolidin-2-ylmethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine was treated with a 37% aq. formaldehyde (1.05 eq.), acetic acid (1.05 eq.) and soduim cyanoborohydride (1.0 eq.) in MeOH at room temperature for 2h to give after purification by preparative HPLC the title compound. ES-MS m/e (%): 464.2(M+H0. Example 269 l'-[(6-ChIoro-l-{[(2R)-l-methylpyrrolidin-2-yl]methyI}-lH-indol-3-yI)carbonyI]- 3H-spiro[2-benzofuran-l,4*-piperidine r-({6-Chloro-l-[(2R)-pyrrolidin-2-ylmethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine (prepared according to the procedure described above for the preparation of l'-({6-chloro-l-[(2S)-pyrrolidin-2-ylmethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine using methanesulfonic acid (R)-l-pyrrolidin-2-ylmethyl ester instead of methanesulfonic acid (S)-l-pyrrolidin-2-ylmethyl ester) was treated with a 37% aq. formaldehyde (1.05 eq.), acetic acid (1.05 eq.) and soduim cyanoborohydride (1.0 eq.) in MeOH at room temperature for 2h to give after purification by prep. HPLC the title compound. ES-MS m/e (%): 464.2(M+H^). Example 270 N-{2-[6-Chloro-3-(l'H,3H.spiro[2-benzofuran-l,4'.piperidin]-l'-ylcarbonyl) indol-l-yl]ethyl}acetamide 2-[6-Chloro-3-(lH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yIcarbonyl)-lH-indol-l-yljethanamine was treated with acetylchloride (1.05 eq) and triethylamine (1.05 eq) in dichloromethane under argon at room temperature.for 2h to give after purification by prep. HPLC the title compound. ES-MS m/e (%): 452.2(M+H^). Example 271 N-{2-[6-Chloro-3-(l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l-ylcarbonyl)-lH- indol-l-yl]ethyl}methanesulfonamide 2-[6-Chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yljethanamine was treated with mesylchloride (1.05 eq) and triethylamine (1.05 eq) in dichloromethane under argon at room temperature.to give after purification by prep. HPLC the title compound. ES-MS m/e (%): 488.1(M+H^). Example 272 N-{2-[6-Chloro-3-(l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH- indol-l-yI]ethyl}-N-methylacetainide N42-[6-Chloro-3-(llI3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]ethyl}acetamide was treated with NaH (1.05 eq), Mel (1.05 eq) in dry DMF under argon at room temperature for 2h to give after purification by prep. HPLC the title compound. ES-MS m/e (%): 466.2(M+H^). Example 273 N-{2-[6-Chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarb^ indoI-l-yl]ethyl}-N-niethyIinethanesulfonainide N-{2-[6-Chloro-3-(l'H3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]ethyl}methanesulfonamide was treated with NaH (1.05 eq), Mel (1.05 eq) in dry DMF under argon at room temperature for 2h to give after purification by prep. HPLC the title compound. ES-MSm/e(%): 502.1(M+H0. Example 274 tert-Butyl 10-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'"ylcarbonyl)-354-dihydropyrazino[l,2-a]indole-2(lH)-carboxylate a) 10-r2.2.2-Trifluoro-acetvlV3,4-dihvdro-lH-pvrazino[L2-a]indole-2-carboxylic acid tert-butvl ester To a stirred solution of 0.21 ml (1.5 mmol) trifluoroacetic anhydride in 7 ml 1,2-dichloroethane was added at 0 °C a solution of 0.37 g (1.4 mmol) 3,4-dihydro-lH-pyrazino[l,2-a]indole-2-carboxylic acid tert-butyl ester and a solution of 0.23 ml (1.63 mmol) triethylamine in 3 ml 1,2-dichloroethane. After stirring for 30 min the reaction mixture was quenched with saturated aqueous sodium hydrogen carbonate solution and extracted with dichloromethane (2 x 100 ml). The combined organic layers were dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography (n-heptane / ethyl acetate) to give the title compound (0.288 g, 58%) as a light yellow solid. MS m/e (%): 369 (M+H^ 27). b) 3,4-Dihvdro-lH-pyrazino[1.2-a]indole-2J0-dicarboxvlic acid 2-tert-butvI ester To a solution of 0.29 g (0.77 mmol) 10-(2,2,2-trifluoTO-acetyl)-3,4-dihydro-lH-pyrazino[l,2-a]indole-2-carboxylic acid tert-butyl ester in 7 ml N,N-dimethylformaniide were subsequently added 0.22 g (4.6 mmol) sodium hydride (50% in oil) and a solution of 0.070 ml (3.9 mmol) water in 1 ml N,N-dimethylformamide at room temperature. The reaction mixture was diluted with tert-butyl methyl ether after 2 h and extracted with 1 M sodium hydroxide solution (2 x 30 ml). The combined aqueous layers were acidified (pH 1-2) with 2 M hydrochloric acid at 0 °C and extracted with tert-butyl methyl ether (3 x 50 ml). The combined organic layers were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.21 g, 86%) as a light brown solid. MS m/e (%): 315 (M-H^ 100). cUert-Butyl 10-(l'R3H-spiro[2-benzofuran-1.4'-piperidin]-r-vlcarbonylV3.4-dihvdropyrazino[l,2-a]indole-2(lH')-carboxvlate To a solution of 0.10 g (0.32 mmol) 3,4-dihydro-lH-pyra2ino[l,2-a]indole-2,10-dicarboxylic acid 2-tert-butyl ester, 0.066 g (0.35 mmol) spiro[isobenzofuran-l(3H),4'-piperidine] and 0.051 g (0.38 mmol) 1-hydroxybenzotriazole in 3.5 ml N,N-dimethylformamide were added 0.073 g (0.38 mmol) N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride at room temperature. After stirring for 3 h the reaction mixture was diluted with saturated aqueous ammonium chloride solution and extracted with tert-butyl methyl ether (2 x 50 ml). The combined organic layers were washed with 1 M sodium hydroxide solution (1 x 30 ml) and water (1 x 30 ml), dried over sodium sulfate, concentrated in vacuo and purified by flash-chromatography (aminopropyl-modified silica gel, n-heptane / ethyl acetate) to give the title compound (0.097 g, 63%) as a light yellow solid. MS m/e (%): 488 (M+H^ 81). Example 275 l'-(l,2,3,4-Tetrahydropyrazino[l,2-a]indol-10-ylcarbonyl)-3H-spiro[2-ben2ofuran- l,4'-piperidine] hydrochloride A mixture of 0.095 g (0.19 mmol) tert-butyl 10-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l-ylcarbonyl)-3,4-dihydropyrazino[l,2-a]indole-2(lH)-carboxylate and 1.56 ml of a 1.25 M solution of hydrochloric acid (1.95 mmol) in methanol was stirred for 15 min at 50 °C. The reaction mixture was concentrated in vacuo to give the title compound (0.084 g, 100%) as a light yellow solid. MS m/e (%): 388 (M+H^ 100). Example 276 l'-[(2-Methyl-l,2,3,4-tetrahydropyrazino[l,2-a]indol-10-yl)carbonyl]-3H-spiro[2- benzofuran-l,4'-piperidine] A solution of 0.050 g (0.12 mmol) l'-(l,2,3,4-tetrahydropyrazino[l,2-a]indol-10-ylcarbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine] hydrochloride, 0.033 ml (0.24 mmol) triethylamine and 0.028 g (0.94 mmol) paraformaldehyde in 2 ml methanol was heated at reflux for 1 h. The reaction mixture was cooled to 0 °C on an ice-water bath and treated with 0.011 g (0.18 mmol) sodium cyanoborohydride. After completed addition the mixture was allowed to warm to room temperature and stirred for 2 h. Quenching with water and dilution with 2 M aqueous sodium carbonate solution was followed by extraction with dichloromethane (2 x 50 ml). The combined organic layers were dried over sodium sulfate, concentrated in vacuo and purified by flash-chromatography (aminopropyl-modified silica gel, n-heptane / ethyl acetate) to give the title compound (0.036 g, 76%) as an off-white solid. MS m/e (%): 402 (M+H^, 100). Example 277 l'-[(6-Chloro-2-methyI-lH-indoI-3-yl)carbonyI]-3H-spiro[2-ben2ofuran-l54'- piperidine] aU6-Chloro-lH-indol-2-vlVmethanol To a solution of 2.00 g (8.94 mmol) 6-chlorindole-2-carboxylic acid ethyl ester in 50 ml diethyl ether were added 0.475 g (12.5 mmol) lithium aluminum hydride at 0 °C. The reaction mixture was heated at reflux for 45 min and quenched by consecutive addition of 10 ml water, 10 ml aqueous 2 M sodium hydroxide solution and 10 ml water at 0 °C. The aqueous layer was extracted with tert-butyl methyl ether (3 x 100 ml). The combined organic layers were dried over sodium sulfate and concentrated in vacuo to give the crude title compound (1.64 g; 100%) as a white solid. MS m/e (%): 180 (M-H^ 100). b) 6-Chloro-2-methvl-lH-indole A solution of 1.60 g (8.81 mmol) (6-chloro-lH-indol-2-yl)-methanol in 5 ml 1,2-dichloroethane was added to a mixture of 80.0 ml trifluoroacetic acid and 32.0 ml triethylsilane at 65 °C. After 5 min, the reaction mixture was cooled to room temperature and quenched with water. The pH was adjusted to 14 by the addition of aqueous sodium hydroxide solution (32 %). The aqueous layer was extracted with tert-butyl methyl ether (3 x 200 ml). The combined organic layers were dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash-chromatography (aminopropyl-modified silica gel, n-heptane / ethyl acetate) to give the title compound (0.39 g; 27%) as a white solid. MS m/e (%): 164 (M-H^ 100). cU-f6-Chloro-2-methvMH-indol-3-vlV2.Z2-trifluoro-ethanone c To a solution of 0.38 g (2.3 mmol) 6-chloro-2-methyl-lH-indole in 20 ml 1,2-dichloroethane at 0 °C were added 0.35 ml (2.5 mmol) trifluoroacetic anhydride. The reaction mixture was quenched with aqueous 2 M sodium carbonate solution after 30 min and extracted with dichloromethane (3 x 100 ml). The combined organic layers were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.57 g; 95%) as an off-white solid. MS m/e (%): 260 (M-H^ 100). d^ 6-Chloro-2-methvl-lH-indole-3-carboxvlic acid A solution of 0.57 g (2.2 mmol) l-(6-chloro-2-methyl-lH-indol-3-yl)-2,2,2-trifluoro-ethanone in 21.7 ml (86.8 mmol) aqueous 4 M sodium hydroxide solution was heated at reflux for 45 min. After cooling to room temperature the reaction mixture was diluted with water and extracted with tert-butyl methyl ether (2 x 50 ml). The aqueous layer was cooled to 0-5 °C, acidified (pH 1-2) with concentrated aqueous hydrochloric acid solution and extracted with ethyl acetate (3 x 100 ml). The combined ethyl acetate layers were dried over sodium sulfate and concentrated in vacuo to give the title compound (0.14 g, 31%) as an off-white solid. MS m/e (%): 208 (M-H^ 100). e) l'-[f6-Chloro-2-methvl-lH-indol-3-vncarbonvl]-3H-spiro[2-benzofuran-l,4'-piperidine] To a solution of 0.040 g (0.19 mmol) 6-chloro-2-methyl-lH-indole-3-carboxylic acid, 0.069 ml (0.40 mmol) N,N-diisopropylethylamine and 0.061 g (0.19 mmol) 2-(lH-benzotriazole-l-yl)-l,l,353-tetramethyluronium tetrafluoroborate in 1 ml dry N,N-dimethylformamide were added 0.036 g (0.19 mmol) spiro[isobenzofuran-l(3H),4'- piperidine] at room temperature. After stirring for 1 h the reaction mixture was quenched with 0.5 M aqueous sodium hydroxide solution (20 ml) and extracted with ethyl acetate (2 X 30 ml). The combined organic layers were washed with water (2 x 30 ml) and brine (1 x 30 ml), dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography (n-heptane / ethyl acetate) to give the title compound (0.036 g, 49%) as a white solid. MS m/e (%): 379 (M-H^ 100). Example 278 l'-({l-[3,5-Bis(trifluoromethyl)benzyI]-6-chloro-2-methyl-lH-indol-3-yI}carbonyI)- 3H-spiro[2-benzofuran-l,4'-piperidine] To a solution of 0.031 g (0.080 mmol) r-[(6-chloro-2-methyl-lH-indol-3"yl)carbonyl]-3H-spiro[2-benzofuran-l,4-piperidine] (5) in 1 ml dry N,N-dimethylformamide were added 0.004 g (0.08 mmol) sodium hydride (50 % in oil). After stirring for 20 min 0.015 ml (0.08 mmol) 3,5-bis(trifluoromethyl)benzyl bromide were added. After stirring for 16 h the reaction mixture was quenched with water and extracted with ethyl acetate (2 x 50 ml). The combined organic layers were washed with water (2 x 30 ml) and brine (1 x 30), dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography (n-heptane / ethyl acetate) to give the title compound (0.020 g; 41%) as a white solid. MS m/e (%): 607 (M+H% 100). Examples of compounds of formula (I-f) Example 279 5-Bromo-l'-(lH-indol-3-ylcarbonyl)spiro[indole-3,4'-piperidin]-2(lH)-one a) 5-Bromo-1.2-dihvdro-2-oxospiro[3H-indole-3>4'-piperidine]-lVethvl A solution of l,2-benzo-8-methyl-3,8-dia2aspiro [4,5] decane-4-one (described in Organic Preparations and Procedures International (1995), 27(6), 691-4)(6.3 g, 29.1 mmol) in CH3CN (100 ml) and MeOH (5 ml) was cooled to ~ 5 °C and NBS (7.8 g, 44 mmol) was slowly added with stirring. The reaction mixture was stirred for 3.5 h at 0°C. Solvent was removed by vacuo. The residue was purified by silica gel chromatography (2 - 20 % MeOH/dichloromethane) to give 6 g of a solid. The solid compound was dissolved in ethyl acetate (600 ml) and washed with saturated aqueous NaHC03 solution, dried (Na2S04). Evaporation of the solvent in vacuo gave 4.2 g (47%) of the desired product. ^HNMR (CD3OD, 400MHz) d 7.51(d, J = 1.8 Hz, IH), 7.35(dd, J = 1.9 and 8.2 Hz, IH), 6.81(d, J = 8.2 Hz, IH), 2.93(m, 2H), 2.67(m, 2H), 2.41(s, 3H), 1.86(m, 4H). b) 5-Bromo-l,2-dihydro-2-oxospiro[3H-indole-3.4^-piperidine]-r-cvano 5-Bromo-l, 2-dihydro-2-oxospiro [3H-indole-3, 4'^-piperidine]-l^-methyl (4.6 g, 15.6 mmol) was dissolved in chloroform (700 ml) and treated with CNBr (22 g, 209.5 mmol) at room temperature. The mixture was heated to reflux for 24h. The reaction mixture was cooled, diluted with methylene chloride (300 ml) and washed with 10 % aqueous K2CO3 solution (2 X 100 ml). After the mixture was dried (Na2S04) and concentrated, the residue was purified by silica gel chromatography (0-5% MeOH/dichloromethane) to give the desired product as a solid (3.9 g, 82%). 'HNMR (CDCI3, 400MHz) 5 7.52 (d, J = 1.8Hz, IH), 7.37(dd, J = 1.8 and 8.2 Hz, IH), 6.82 (d, J = 8.2 Hz, IH), 3.83(m, 2H), 3.41(m, 2H), 2.00(m, 2H), 1.86(m, 2H). c) 5-Bromospiro[indole-3,4'-piperidin]-2QHVone 5-Bromo-l,2-dihydro-2-oxospiro[3H-indole-3,4^-piperidine]-l^-cyano (3.3 g, 10.8 mmol) was suspended in ethylene glycol (10 ml). The mixture was treated in NaOH (1.8 g, 45 mmol) and heated to 130** C for 15 min. It was diluted with methylene chloride (500 ml) and washed with 10% aqueous K2CO3 (2 x 100 m). The organic layer was dried (Na2S04) and concentrated and residue purified by silica gel chromatography (30% MeOH/dichloromethane) to give the desired product as a light ceramic white solid (1.8 g, 60%). Mp 256 - 258^ C. ^HNMR (DMSO-de, 400MHz) 8 10.6(br s, IH, NH), 7.57(d, J = 1.84Hz, IH), 7.36(d, J = 8.2Hz, IH), 6.79(d, J = 8.2 Hz, IH), 4.05 (br s, IH, NH), 3.06(m, 2H), 2.84(m, 2H), 1.64(m, 2H), 1.55(m, 2H), ^'^C NMR (DMSO-dfi, lOOMHz) 5 180.93,140.64,137.98,130.42,126.75, 113.20,111.45, 46.24, 40.92, 32.94. Anal.Calcd for Ci2Hi3BrN20: C, 51.26; H, 4.66; N, 9.9. Found: C, 50.87; H, 4,91; N, 9.67. d^ 5-Bromo-r-riH-indol-3-vlcarbQnvnspiro[indole-3,4'-piperidin]-2QHVone Following the general procedure I as described above, the acylation of 5-bromospiro[indole-3,4'-piperidin]-2(lH)-one with lH-indole-3-carboxylic acid (commercially available), gave the title compound. ES-MS m/e (%): 424.3(M+H^). Example 280 5-Bromo-l'-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[indole-3,4'-piperidin]-2(lH)- one Following the general procedure I as described above, the acylation of 5-bromospiro[indole-3,4'-piperidin]-2(lH)-one with 6-chloro-lH-indole-3-carboxylic acid (preparation described in example 5 above), gave the title compound. ES-MS m/e (%): 458.3(M+H0. Example of compounds of formula (I-g) Example 281 was evaporated. The residual oil was redissolved in 300 ml tert-butyl methyl ether and washed with saturated aqueous ammonium chloride solution (1 x 100 ml) and water (1 x 100 ml). The combined aqueous layers were extracted with tert-butyl methyl ether (1 x 200 ml). The combined organic layers were dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography (n-heptane / ethyl acetate) to give the title compound (9.6 g, 71%) as a colourless oil. MS m/e (%): 186 (M-C4H8+H^ 100). b) 4-(2-Bromo-phenvlV4-cvano-piperidine-l-carboxvlic acid tert-butyl ester A mixture of 4.50 g (23.0 mmol) 3-bromophenylacetonitrile and 0.78 g (2.3 mmol) tetrabutylammonium hydrogensulfate in 27 ml tetrahydrofuran and 45 ml of a 50 % aqueous sodium hydroxide solution was heated at reflux for 10 min. Thereafter 6.11 g (25.3 mmol) bis-(2-chloro-ethyl)-carbamic acid tert-butyl ester were added at room temperature. The reaction mixture was heated at reflux for 4 h. Cooling to room temperature was followed by dilution with 60 ml water and extraction with tert-butyl methyl ether (3 x 100 ml). The combined organic layers were washed with brine (1 x 100 ml), dried over sodium sulfate and concentrated in vacuo. The residual crude product was purified by flash chromatography (n-heptane / ethyl acetate) to give the title compound (6.72 g, 80%) as a pale yellow oil. MS m/e (%): 265, 267 (M-BOC+H^ 82, 100). c) 4-r2-Bromo-phenvlVpiperidine-L4-dicarboxvlic acid mono-tert-butvl ester A mixture of 5.7 g (15.6 mmol) 4-(2-bromo-phenyl)-4-cyano-piperidine-l-carboxylic acid tert-butyl ester and 235 ml (936 mmol) of a 4 M aqueous hydrochloric acid solution was heated at reflux for 96 h. After cooling to room temperature the reaction mixture was basified with 93.90 ml (1014 mmol) of a 10.8 M aqueous sodium hydroxide solution and diluted with 200 ml 1,4-dioxane. A solution of 5.11 g (23.4 mmol) di-tert-butyl dicarbonate in 50 ml 1,4-dioxane was added quickly at 0 °C. After stirring for 2 h the reaction mixture was extracted with tert-butyl methyl ether (2 x 100 ml). The combined organic layers were washed with 1 M sodium hydroxide solution (1 x 100 ml). The combined aqueous layers were cooled by the addition of 100 g ice, acidified (pH 1-2) with ice-cold 2 M aqueous hydrochloric acid solution and extracted with ethyl acetate (3 x 150 ml). The combined ethyl acetate layers were dried over sodium sulfate and concentrated in vacuo to give the title compound (5.51 g, 92%) as a light yellow solid. MS m/e (%): 382, 384 (M+H^ 90, 100). d) 4-Azidocarbonvl-4-r2-bromo-phenvlVpiperidine-l-carboxvlic acid tert-butvl ester To a solution of 2.00 g (5.20 mmol) 4-(2-bromo-phenyl)-piperidine-l,4-dicarboxylic acid mono-tert-butyl ester in 26 ml dichloromethane were added 0.76 ml (5.73 mmol) 1-chloro-N,N,2-trimethylpropenylamine at room temperature. After stirring for 45 min the reaction mixture was concentrated in vacuo. The residual oil was redissolved in 26 ml dry N,N-dimethylformamide and treated with 0.51 g (7.8 mmol) sodium azide. After stirring for 1 h the reaction mixture was diluted with 200 ml tert-butyl methyl ether and washed with 0.5 M aqueous sodium carbonate solution (2 x 50 ml). The combined aqueous layers were extracted with tert-butyl methyl ether (2 x 100 ml). The combined organic layers were washed with water (1 x 50 ml) and brine (1 x 50 ml), dried over sodium sulfate and concentrated in vacuo to give the crude title compound (1.76 g, 83%) as a light yellow solid. c) tert-Butvl 3-oxo-2.3-dihydro-l'H-spiro[isoindole-1.4^-piperidine]-l'-carboxylate A solution of 1.60 g (3.91 mmol) 4-azidocarbonyl-4-(2-bromo-phenyl)-piperidine-l-carboxylic acid tert-butyl ester in 40 ml toluene was stirred at 90 °C for 1 h. The reaction mixture was concentrated in vacuo and the residue was redissolved in 40 ml dry tetrahydrofuran. Cooling of the solution to -100 °C was followed by slow dropwise additon of 4.6 ml (7.8 mmol) of a 1.7 M solution of tert-butyl lithium in pentane. The cooling bath was removed after 10 min and the reaction mixture was allowed to warm to 0 °C. After quenching with 5 ml saturated aqueous ammonium chloride solution the mixture was extracted with tert-butyl methyl ether (3 x 50 ml). The combined organic layers were washed with brine (1 x 50 ml), dried over sodium sulfate and concentrated in vacuo to give the title compound (1.15 g, 97%) as a light yellow solid. MS m/e (%): 247 (M-C4H8+H^ 100). f) Spiro[isoindole-l,4'-piperidin]-3r2HVone To a solution of 0.10 g (0.33 mmol) tert-butyl 3-oxo-2,3-dihydro-l'H-spiro[isoindole-l,4'-piperidine]-r-carboxylate in 3.3 ml dichloromethane were added 0.25 ml (3.3 mmol) trifluoroacetic acid at room temperature. After stirring for 4 h the reaction mixture was diluted with 20 ml aqueous 1 M sodium hydroxide solution (20 ml) and extracted with ethyl acetate (3 x 50 ml). The combined organic layers were dried over sodium sulfate and concentrated in vacuo to give the crude title compound (0,095 g) as a light yellow solid. MS m/e (%): 203 (M+H^ 100). g) r-[r6-Chloro-lH-indol-3-vncarbonvl]spiro[isoindQle-l,4'"piperidin]-3r2HVone To a solution of 0.060 g (0.31 mmol) 6-chloro-lH-indole-3-carboxylic acid in 3 ml dichloromethane were added 0.045 ml (0.38 mmol) l-chloro-N,N,2-trimethyl-propenylamine at room temperature. After stirring for 1 h the reaction mixture was concentrated in vacuo. The residue was redissolved in 2 ml dry N,N-dimethylformamide. A solution of 0.062 g (0.31 mmol) spiro[isoindole-l,4'-piperidin]-3(2H)-one and 0.064 ml (0.46 mmol) triethylamine in 1 ml dry N,N-dimethylformamide was added at room temperature. After stirring for 2 h the reaction mixture was quenched with 1 M aqueous sodium hydroxide solution (30 ml) and extracted with ethyl acetate (3 x 50 ml). The combined organic layers were washed with water (2 x 30 ml), 0.5 M aqueous hydrochloric acid solution (1 x 30 ml) and brine (1 x 30 ml), dried over sodium sulfate and concentrated in vacuo. The crude product was triturated in warm diethyl ether, filtrated and dried in vacuo to give the title compound (0.031 g, 22%) as light brown solid with a purity of approx. 80 % by LC-.MS. MS m/e (%): 378 (M-H\ 100). Example 283 2-{6-ChIoro-3-[(3-oxo-2,3-dihydro-l'H-spiro[isoindole-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}-N-methylacetamide To a solution of 0.35 g (0.13 mmol) 6-chloro-l-methylcarbamoylmethyl-lH-indole-3-carboxylic acid, 0.025 ml (0.14 mmol) N,N-diisopropylethylamine and 0.055 g (0.14 mmol) 0-(7-azabenzotriazol-l-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in 2 ml dry N,N-dimethylformaiTiide were added 0.029 g (0.14 mmol) spiro[isoindole-l,4'-piperidin]-3(2H)-one at room temperature. After stirring for 2 h the reaction mixture was quenched with 0.5 M aqueous sodium hydroxide solution (20 ml) and extracted with ethyl acetate (2 x 30 ml). The combined organic layers were washed with water (2 x 30 ml) and brine (1 x 30 ml), dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography (aminopropyl-modified silica gel, dichloromethane / methanol) to give the title compound (0.026 g, 44%) as a white solid. MS m/e (%): 451 (M+H^ 100). Example 284 l'-[(6-Chloro-lH-indol-3-yl)carbonyl]-2,3-dihydrospiro[isoindole-l,4'-piperidine] a) tert-Butvl 2,3-dihvdro-rH-spiro[isoindole-1.4'-piperidine]"r-carboxvIate To a solution of 0.20 g (0,66 mmol) tert-butyl 3-oxo-2,3-dihydro-lH-spiro[isoindole-l,4'-piperidine]-r-carboxylate in 6.6 ml toluene were added 0.33 ml (0.66 mmol) of a 2 M solution of borane dimethylsulfide complex in tetrahydrofuran. After stirring at reflux for 5 h the mixture was cooled to room temperature, treated with 1,5 ml of methanol and reheated to reflux for 15 min. The reaction mixture was then concentrated in vacuo to give the crude title compound (0.23 g, 84.%) as a light yellow solid with a purity of 70 % by LC-MS. MS m/e (%): 289 (M+H^ 83). b^ 2.3-Dihydrospiro[isoindole-l,4'-piperidine] dihydrochloride A solution of 0.16 g (0.56 mmol) tert-butyl 2,3-dihydro-rH-spiro[isoindole-l,4'-piperidine]-r-carboxylate in 4.5 ml (5.6 mmol) of a 1.25 M solution of hydrochloric acid in methanol was stirred at 50 °C for 30 min. The reaction mixture was concentrated in vacuo. The residue was triturated in hot tetrahydrofuran, filtrated and dried in vacuo to give the title compound (0.15 g, 100%) as a light yellow solid. MS m/e (%): 189 (M+H^ 100). c) r-[f6-Chloro-lH-indol-3-yncarbonvI]-23-dihvdrospiro[isoindole-l,4'-piperidine] To a solution of 0.10 g (0.51 mmol) 6-chloro-lH-indole-3-carboxylic acid in 5 ml dichloromethane were added 0.074 ml (0.56 mmol) l-chloro-N,N,2-trimethyl-propenylamine at room temperature. The reaction mixture was concentrated in vacuo after 1 h. The residue was redissolved in 2 ml dry N,N-dimethylformamide. A suspension of 0.147 g (0.56 mmol) 2,3-dihydrospiro[isoindole-l,4'-piperidine] dihydrochloride and 0.285 ml (2.04 mmol) triethylamine in 2 ml dry N,N-dimethylformamide was added at room temperature. After stirring for 16 h the reaction mixture was quenched with 1 M aqueous sodium hydroxide solution (30 ml) and extracted with ethyl acetate (3 x 50 ml). The combined organic layers were washed with water (2 x 30 ml) and brine (1 x 30 ml), dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography (dichloromethane / methanol) to give the title compound (0.045 g; 24%) as an off-white solid. MS m/e (%): 366 (M+H^ 100). Example 285 l'-[(6-Chloro-lH-indol-3-yl)carbonyl]-2-methyI-2,3-dihydrospiro[isoindole-l,4'- piperidine] a) tert-Butvl 2-methvl-3-oxo-23-dihvdro-rH-spiro[isoindole-1.4'-piperidine]-l'-carboxvlate To a solution of 0.310 g (1.03 mmol) spiro[isoindole-l,4'-piperidin]-3(2H)-one-l-carboxylic acid tert-butyl ester in 10 ml N,N-dimethylformamide were added 0.054 g (1.1 mmol) sodium hydride (50 % in oil) at room temperature. After stirring for 30 min 0.067 ml (1.1 mmol) iodomethane were added. The reaction mixture was quenched with water after 1 h and extracted with tert-butyl methyl ether (2 x 100). The combined organic layers were washed with water (2 x 50 ml) and brine (1 x 50 ml), dried over sodium sulfate and concentrated in vacuo to give the title compound (0.32 g, 99%) as light yellow solid. MS m/e (%): 317 (M+H^ 21). b) tert-Butvl 2-methvl-2,3-dihvdro-rH-spiro[isoindole-l,4'-piperidine]-l'-carboxvlate To a solution of 0.10 g (0.32 mmol) tert-butyl 2-methyl-3-oxo-2,3-dihydro-rH-spiro[isoindole-l,4'-piperidine]-l'-carboxylate in 3.2 ml toluene were added 0.16 ml (0.32 mmol) of a 2 M solution of borane dimethylsulfide complex in tetrahydrofuran. After heating at reflux for 4 h the reaction mixture was cooled to room temperature, quenched with 1.5 ml of methanol and reheated to reflux for 15 min. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography (n-heptane / ethyl) to give the title compound (0.057 g, 60%) as a light yellow solid. MS m/e (%): 303 (M+H^ 100). c) 2-Methvl-2,3-dihvdrospiro[isoindole-1.4'-piperidine] A solution of 0.057 g (0.33 mmol) tert-butyl 2-methyl-2,3-dihydro-rH-spiro[isoindole-l,4'-piperidine]-r-carboxylate in 1.32 ml (1.65 mmol) of a 1.25 M solution of hydrochloric acid in methanol was stirred at 50 °C for 15 min. The reaction mixture was concentrated in vacuo. The residue was dissolved in 2 M aqueous sodium hydroxide solution and extracted with dichloromethane (3 x 50 ml). The combined organic layers were dried over sodium sulfate and concentrated in vacuo to give the crude title compound (0.041 g) as a pale yellow amorphous solid. MS m/e (%): 203 (M+H^ 100). d) r-[(6-Chloro-lH-indol-3-vncarbonvl]-2-methvl-23"dihvdrospiro[isoindole-1.4'- piperidine] To a solution of 0.040 g (0.20 mmol) 6-chloro-lH-indole-3-carboxylic acid in 3 ml dichloromethane were added 0.03 ml (0.22 mmol) l-chloro-N,N,2-trimethyl-propenylamine at room temperature. After stirring for 1 h the reaction mixture was concentrated in vacuo. The residue was redissolved in 2 ml dry N,N-dimethylformamide. A solution of 0.041 g (0.20 mmol) 2-methyl-2,3-dihydrospiro[isoindole-l,4-piperidine] and 0.043 ml (0.31 mmol) triethylamine in 1 ml dry N,N-dimethylformamide was added at room temperature. After stirring for 2 h the reaction mixture was quenched with 1 M aqueous sodium hydroxide solution (30 ml) and extracted with ethyl acetate (3 x 50 ml). 12. The compounds of formula (I-b) according to any one of claims 9 to 11, wherein said compounds are selected from the group consisting of: r-[(l-benzyl-2-methyl-lH"indol-3-yl)carbonyl]-l-(methylsulfonyl)-l,2-dihydrospiro[indole-3,4'-piperidine]; l'-{[6-chloro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine]; l'-{[6-chIoro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine]; r-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine]; l'-{[6-chloro-l-(23-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine]; l'-({6-chloro-l-[(3,5-difluorophenyl)sulfonyl]-lH-indol-3-yl}carbonyl)-l,2-dihydrospiro[indole-3,4'-piperidine]; 2-[6-chloro-3-(l,2-dihydro-rH-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-l-(3,5-difluorophenyl)ethanone; 2-[6-chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-l-(3,4-difluorophenyl)ethanone; 2-[6-chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH. indol-l-yl]-l-(2-fluorophenyl)ethanone; 2-[6-chloro-3-(l,2-dihydro-l'H-spiro[indole-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N,N-diethylethanamine; and r-{[6-chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-l,2-dihydrospiro[indole-3,4'-piperidine]. 13. The compounds of formula (I-c) according to any one of claims 1 to 4: or is -(CO)-R^ wherein K" is: Ci^-alkyl -(CH2)n-NR'R", -(CH2)n-NR"^R'5 or 6 membered heterocycloalkyl optionally substituted by C]-6-alkyl; R is one or more of H, halo, or C]-6-alkoxy optionally substituted by OH, or two R'^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; B is halo, NH2, C].6-alkyl optionally substituted by CN or C]-6-alkoxy, Cj^-alkoxy, Ci^-haloalkoxy, C3.6-cycloalkyl, -C(0)0-Ci.6-alkyl, -(CR"^R*^)n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, C].6-alkyl optionally substituted by CN or halo, C]-6-alkoxy; R' and R" are H, Ci^-alkyl, Ci^-alkyl-NR'"R'\ -(CO)O-Ci^-alkyl, -C(0)-NR'"R'\ -C(0)- Ci-6-alkyl, -S(0)2-Ci-6-alkyl, -S(0)2- NR"'R'; R"' and R'" are H or Ci^-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. 15. The compounds of formula (I-c) according to claim 13 or 14, wherein said compounds are selected from the group consisting of: l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-chloro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-4-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-methoxy-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-5-methoxy-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-7-chloro-3H-spiro[2-benzofuran-1,4'-piperidin] -3-one; r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-[(6-chloro-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-N,N-dimethyl-lH-indole-2-carboxamide; tert-butyl{2-[({6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-2-yl}carbonyI)amino]ethyl}methylcarbamate; 6-chloro-N,N-diethyl-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indole-2-carboxamide; r-{[6-chloro-2-(piperidin-l-ylcarbonyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-7H-spiro[furo[3,4-f][l,3]benzodioxole-5,4'-piperidin]-7-one; 3-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}propanenitrile; {6-chloro-3-[(3-oxo-l'H,3H-spiro[2-ben2ofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}acetonitrile; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-(2-hydroxyethoxy)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(3,5-difluorophenyl)-lH-indol-3-yl]carboTiyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[2-(3-fluorophenyI)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[2-(2,5-difluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4*-piperidin]-3-one; r-({6-chloro-l-[2-(3-fluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4-piperidiii]-3-one; 5-bromo-l'-{[6-chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 5-bromo-l'-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yI]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 5-bromo-r-({6-chloro-l-[2-(3-fluorophenyl)-2-oxoethyl]-lH-indol-3-yI}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[2-(2-fluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4-piperidin]-3-one; r-({6-chloro-l-[2-(3,4-difluorophenyl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(3-fluorophenyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indoI-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(2-morpholin-4-yl-2-oxoethyI)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 2-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}-N,N-dimethyIacetamide; 2-{6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}-N,N-diethylacetamide; r-{[6-chloro-l-(piperidin-l-ylcarbonyl)-lH-indol-3-yl]carboiiyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; tert-butyl {6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}acetate; r-[(6-chloro-l-pyridin-2-yl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'- piperidin]-3-one; l'-[(6-chloro-l-pyridin-2-yl-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2- benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(2-methylpyridin-4-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(6-chloropyridin-3-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidiTi]-3-one; l'-({6-chloro-l-[(3-chloro-6-niethylpyridazin-4-yl)methyl]-lH-indol-3-yl}carbonyI)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(pyridin-4-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4-piperidin]-3-one; l'-{[6-chloro-l-(2-pyridin-4-ylethyI)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuraii-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(pyridin-4-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[6-chloro-l-(2-oxo-2-pyridin-2-ylethyl>lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[2-(5-methyl-2-phenyl-l,3-oxazol-4-yl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyI}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 2-{6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl] - IH-indol-1 -yl} -N,N-dimethylacetamide; l'-({6-chloro-l-[2-(dimethylainino)ethyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(pyridin-3-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(pyrazin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4-piperidin]-3-one; r-{[6-chloro-l-(pyrimidin-5-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; 3-{6-chloro-3-[(5-fluoro-3-oxo-l'H3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}propanenitrile; tert-butyl {6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}acetate; r-{[6-chloro-l-(2-inorpholin-4-yl-2-oxoethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({l-[(4-benzylmorpholin-2-yl)methyl]-6-chIoro-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(5-methyIisoxazol-3-yI)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[2-(4-methylpiperazin-l-yl)-2-oxoethyI]-lH-iiidol-3-yI}carbonyI)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-{[6-chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyI}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(5-cyclopropyl-2-methyl-l,3-oxazol-4-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4*-piperidin]-3-one; l*-({6-chloro-l-[(l-methyl-lH-imidazol-5-yl)methyl]-lH-indol-3-yl}carboTiyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(3-methylisoxazol-5-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(l,5-dimethyl-lH-pyrazol-3-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(3,5-dimethylisoxazol-4-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(2,5-dimethyl-l,3-oxazol-4-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-({6-chloro-l-[(3-fluorooxetan-3-yl)methyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-({6-chloro-l-[(3-fluorooxetaii-3-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; l'-[(6-chloro-l-{[l-(methoxymethyI)-cyclopropyl]methyl}-lH-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; [l-({6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}methyl)cyclopropyl]acetonitrile; l'-[(6-chloro-l-{[l-(methoxymethyl)-cyclopropyl]methyl}-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4*-piperidin]-3-one; [l-({6-chloro-3-[(3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}methyl)cyclopropyl]acetonitrile; r-({6-chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one hydrochloride; l'-({6-chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yI}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; tert-butyl 2-({6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4-piperidin]-r-yl)carbonyI]-lH-indol-l-yl}methyl)morpholine-4-carboxylate; tert-butyl 2-({6-chloro-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'^piperidin]-r-yl)carbonyl]-lH-indol-l-yl}methyl)morpholine-4-carboxylate; l'-{[6-chloro-l-(morpholin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one dihydrochloride; l'-{[6-chloro-l-(morpholin-2-yImethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one hydrochloride; 2-{6-chloro-3-[(5-fluoro-3-oxo-rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}acetamide; 2-{6-chloro-3-[(5-fluoro-3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}-N-methylacetamide; l'-{[6-chloro-l-(2-oxo-2-piperazin-l-ylethyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; r-{[l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; N,N-diethyl-2-{3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}acetamide; and 2-{6-chloro-5-methyl-3-[(3-oxo-l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-yl)carbonyl]-lH-indol-l-yl}-N,N-dimethylacetamide. 16. The compounds of formula (I-d) according to any one of claims 1 to 4: wherein R^ to R^ are as defined in any one of claims 1 to 4. 17. The compounds of formula (I-d) according to claim 16, wherein R^ is H, or is Ci-6-alkyl optionally substituted by CN, or is aryl, 5 or 6 membered heteroaryl or sulfonylaryl which are optionally substituted by one or more B, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR'R", C3-6-cycloalkyl, 3 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R*' wherein R*' is: C],6-alkoxy, NR'R", 4 to 7 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or R and R together with the indole ring to which they are attached form a 5 or 6 membered heterocycloalkyl which can be substituted by C(0)0-Ci.6-alkyl or Ci^-alkyl; R^ is one or more of H, halo, C]-6-alkyl, Ci^-alkoxy; R^ is H, oris Ci-6-alkyl, or is -(CO)-R^ wherein R^ is Ci-6-alkyl, or -(CH2)n-NR'R"; R is one or more of H, halo, or Ci_6-alkoxy optionally substituted by OH, or two R may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ is H or aryl; B is halo, NH2, Ci.6-alkyl optionally substituted by CN or C].6-alkoxy, Ci^-alkoxy, Ci^-haloalkoxy, C3-6-cycloalkyl, -C(0)0-Ci-6-alkyl, -(CR'"R')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, Ci-6-alkyl optionally substituted by CN or halo, C]-6-alkoxy; R' and R" are H, Ci-6-alkyl, C,^-alkyl-NR'"R'\ -(C0)0-Ci.6-alkyl, -C(0)-NR^'R'\ -C(0)-Ci^-alkyl, -S(0)2-Ci-6-alkyl, -S(0)2- NR"'R'^ or OH; R"' and R*' are H or Ci_6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. 18. The compounds of formula (I-d) according to claim 16 or 17, wherein said compounds are selected from the group consisting of: r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-6-chloro-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-benzoyl-2-methyMH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[2-methyl-l-(phenylsulfonyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[l-(cyclohexylmethyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzof uran-1,4'-piperidine]; r-{[l-(3-fluorobenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-({2-methyl-l-[2-(trifluoromethoxy)benzyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[l-(3,5-dimethylbenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-lj4'-piperidine]; methyl 4-{[2-methyl-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indoM-yl]methyl}benzoate; 4-{[2-methyl-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]methyl}benzonitrile; l'-{[l-(3,5-difluorobenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[l-(2-chlorobenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[l-(2-inethoxybenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzof uran-1,4'-piperidine]; l'-{[l-(4-methoxybenzyl)-2-methyl-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(l-{[2-(2-methoxyphenyl)-5-methyl-l,3-oxazol-4-yl]methyl}-2-methyMH-indol-3-yl)carbonyI]-3H-spiro[2-benzofuran-l,4-piperidine]; r-[(l-benzyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(6-chloro-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; N,N-dimethyl-2-[3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]ethanamine; 2-methyI-l-[3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-2-yl]butan-l-one; [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yljacetonitrile; r-{[6-chloro-l-(3-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(2-fluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-{[6-chloro-l-(3,5-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(2,3-difluorobenzoyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-{[6-chloro-l-(3,5-difluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2- benzofuran-l,4'-piperidine]; l'-{[6-chloro-l-(3-fluorobenzyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-{[6-chloro-l-(2-morpholin-4-yl-2-oxoethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]-N,N-dimethylacetamide; 2-[6-chloro-3-(lH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N,N-diethylacetamide; r-{[6-chloro-l-(piperidin-l-ylcarbonyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzof uran -1,4'-piperidine]; lert-butyl [6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]acetate; r-{[6-chloro-l-(3,5-difluorophenyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine]; r-{[6-chloro-l-(3-fluoropheTiyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]-l-(2-fluorophenyl)ethanone; r-[(6-chloro-l-pyridin-2-yl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidine]; r-{[6-chloro-l-(pyridin-4-ylmethyl)-lH-indol-3-yI]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; 2-[6-chloro-3-(l'H3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]-l-pyridin-2-ylethanone; l'-{[6-chloro-l-(pyridin-3-ylniethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(pyridin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(pyrazin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzof uran-1,4'-piperidine]; r-{[6-chloro-l-(pyrimidin-5-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N,N-dimethylethanamine; r-{[6-chloro-l-(2-oxo-2-piperazin-l-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-({l-[(4-benzylmorpholin-2-yl)methyI]-6-chloro-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(5-methylisoxazol-3-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[2-(4-methylpiperazin-l-yl)-2-oxoethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; 4-(l-{l-[(2-cyclopropyl-4-methylcyclopenta-l,4-dien-l-yl)methyl]-6-methyl-lH-inden-3-yl}vinyl)-2',3'-dihydrospiro[cyclohexane-l,r-indene]; l'-({6-chloro-l-[(l-methyl-lH-imidazol-5-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4-piperidine]; r-({6-chloro-l-[(3-inethyIisoxazol-5-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(l,5-dimethyl-lH-pyrazol-3-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-({6-chloro-l-[(3,5-dimethylisoxazol-4-yI)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(2,5-dimethyl-l,3-oxazol-4-yl)methyl]-lH-indol-3"yl}carbonyl)-3H-spiro[2-benzofuran-l,4-piperidine]; l'-({6-chloro-l-[(3-fluorooxetan-3-yl)methyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; l'-[(6-chloro-l-{[l-(methoxymethyl)-cyclopropyl]methyl}-lH-indol-3-y])carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; (l-{[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l*-ylcarbonyl)-lH-indol-l-yl]methyl}cyclopropyI)acetonitrile; r-({6-chloro-l-[2-(tetrahydro-2H-pyran-4-yl)ethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; tert-butyl2-{[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]methyl}morpholine-4-carboxylate; r-{[6-chloro-l-(morpholin-2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine] hydrochloride; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarboiiyl)-lH-indol-l-yl]-N-[2-(dimethylamino)ethyl]acetamide; 2-[6-chloro-5-methyl-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N,N-dimethylacetamide; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]acetamide; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]-N-[2-(methylamino)ethyl]acetamide; N-(2-aminoethyl)-2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]acetamide; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]ethanamine; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N-methylethanamine; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N-methylacetamide; l'-{[6-chIoro-l-(2-morphoIin-4-ylethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(3-morpholin-4-ylpropyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine]; r-{[6-chloro-l-(oxiran-2-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; 2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]ethanol; l'-({6-chloro-l-[(2-methylpyridin-4-yl)methyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4-piperidine]; r-({6-chloro-l-[(3S)-piperidin-3-ylmethyl]-lH-indol-3-yl}carbonyl)-3H-spiro[2- benzofuran-l,4'-piperidine]; 2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol- l-yl]-N-hydroxyethanamine; l'-{[6-chloro-l-(tetrahydro-2H-pyran-4-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(l-methylpyrrolidin-3-yl)methyl]-lH-indol-3-yl}carbonyl)-3H- spiro[2-benzofuran-l,4'-piperidine]; r-[(6-chloro-l-{[(3S)-l-methylpiperidin-3-yl]methyl}-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-{[6-chloro-l-(pyrrolidin-3-ylmethyl)-lH-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-l,4'-piperidine]; r-({6-chloro-l-[(2S)-pyrrolidin-2-ylmethyl]4H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(6-chloro-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-(l,2,3j4-tetrahydropyrazino[l,2-a]indol-10-ylcarbonyl)-3H-spiro[2-benzofuran-l,4'-piperidine] hydrochloride; r-[(2-methyl-l,2,3,4-tetrahydropyrazino[l,2-a]indol-10-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; r-[(6-chloro-2-methyl-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]; N-{2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indoI-l-yl]ethyl}acetamide; N-{2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]ethyl}methanesulfonamide; N-{2-[6-chloro-3-(rH,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yI]ethyl}-N-methylacetamide; N-{2-[6-chloro-3-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]ethyl}-N-methylmethanesulfonamide; r-[(6-chloro4-{[(2S)4-methylpyrrolidin-2-yl]methyl}-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4-piperidine]; and r-[(6-chloro-l-{[(2R)-l-methylpyrrolidin-2-yl]methyl}-lH-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-l,4'-piperidine]. 19. The compounds of formula (I-e) according to any one of claims 1 to 4: 4 A «% jf f wherein R , R , R , R and R are as defined in any one of claims 1 to 4. 20. The compounds of formula (I-e) according to claim 19, wherein R^ is H, or is Ci_6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR", CN, NR'R", C3-6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R\ wherein R^ is: C]-6-alkoxy, NR^R^ 5 or 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R" is one or more of H, halo, Ci-6-alkyl; R-^ is H, oris C].6-alkyl, or is -(CO)-R^ wherein R*" is: Ci^-alkyl -(CH2)n-NR*R", R"* is is one or more of H, halo, or Ci_6"alkoxy optionally substituted by OH, or two R may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ is H; B is halo, CN, C].6-alkyl optionally substituted by CN or Ci_6-alkoxy, C].6-alkoxy, Ci-6-haloalkoxy, Cs-e-cycloalkyl, -C(0)0-Ci-6-alkyl, -(CR"'R^')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, Ci_6-alkyl optionally substituted by CN or halo, C].6-alkoxy; R'and R" are H, Q^-alkyl, C]-6-alkyl-NR'"R*\ -C(0)-Ci^-alkyl, -S(0)2-Ci_6-alkyl or OH; R'" and R*^ are H or Ci_6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. 21. The compounds of formula (I-e) according to claim 19 or 20, wherein R^ is H or, -(CH2)m-R^ wherein R^ is 5 or 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl, -(CH2)m-NR'R" or, -(CH2)n-(C0)-R*', wherein R*" is 5 or 6 membered-heterocycloalkyl; R^ is one or more of H or halo; R-^ is H, or is C].6-alkyl; R'^ is one or more of H or halo; R^ is H; R' and R" are C]-6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. 22. The compounds of formula (I-e) according to any one of claims 19 to 21, wherein said compounds are selected from the group consisting of: r-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine]; r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine]; r-(lH-indol-3-ylcarbonyl)spiro[l-benzofuran-3,4'-piperidine]; r-[(6-chloro-5-fluoro-lH-indol-3-yl)carbonyl]spiro[l-benzofuran-3,4'-piperidine]; 2-[6-chloro-3-(l'H-spiro[l-benzofuran-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N,N-dimethylethanamine; r-{[6-chloro-l-(2-pyrrolidin-l-ylethyl)-lH-indol-3-yl]carbonyl}spiro[l-benzofuran-3,4'-piperidine]; 3-[6-chloro-3-(l'H-spiro[l-benzofuran-3,4'-piperidin]-r-ylcarbonyl)-lH-indol-l-yl]-N,N-dimethylpropan-l-amine; r-{[6-chloro-l-(2-morpholin-4-ylethyl)-lH-indol-3-yl]carbonyl}spiro[l-benzofuran-3,4'-piperidine]; 2-[6-chloro-3-(rH-spiro[l-benzofuran-3,4'-piperidin]-l'-ylcarbonyl)-lH-indol-l-yl]-N,N-diethylethanamine; r-({6-chloro-l-[2-(lH-pyrrol-l-yl)ethyl]-lH-indol-3-yl}carbonyl)spiro[l-benzofuran-3,4'-piperidine]; and r-{[6-chloro-l-(2-oxo-2-piperidin-l-ylethyl)-lH-indol-3-yl]carbonyl}spiro[l-benzofuran-3,4'-piperidine]. 1 T Q A wherein R , R , R , and R are as defined in any one of claims 1 to 4. 24. The compounds of formula (I-f) according to claim 23, wherein R^ is H, or is Ci.6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: 0R\ CN, NR'R", C3-6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^ wherein R*' is: Ci.6-alkoxy, NR'R", 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; •J R is one or more of H, halo, Ci-6-alkyl; R-^ is H, or is Ci.6-alkyl, or is -(CO)-R^ wherein R"" is: Ci^-alkyl -(CH2)n-NR'R", R"* is is one or more of H, halo, or Ci.6-alkoxy optionally substituted by OH, or two R'^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; B is halo, CN, Ci^-alkyl optionally substituted by CN or Ci^-alkoxy, Ci.6-alkoxy, C]-6-haloalkoxy, Cj-e-cycloalkyl, -C(0)0-Ci.6-alkyl, -(CR'"R'')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, Ci^-alkyl optionally substituted by CN or halo, Ci-6-alkoxy; R* and R" are H, Ci^-alkyl, Ci-6-alkyl-NR*"R'\ -C(0)-C]-6-alkyl, -S(0)2-C]^-alkyl or OH; R"' and R'" are H or Ci.6-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. 25. The compounds of formula (I-f) according to claim 23 or 24, wherein R^ is H; R^ is one or more of H or halo; R-^ is H; R"^ is one or more of H or halo; as well as pharmaceutically acceptable salts thereof. 26. The compounds of formula (I-f) according to any one of claims 23 to 25, wherein said compounds are selected from the group consisting of 5-bromo-r-(lH-indol-3-ylcarbonyl)spiro[indole-3,4'-piperidin]-2(lH)-one; and 5-bromo-r-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[indole-3,4*-piperidin]-2(lH)-one. wherein R\ R^, R^, and R'^ are as defined in any one of claims 1 to 4. 28. The compounds of formula (I-g) according to claim 27, wherein R^ is H, or is Ci.6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR", CN, NR'R", C3-6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0)-R^, wherein R*' is: Ci.6-alkoxy, NR'R", 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R" is one or more of H, halo, Ci-6-alkyl; R^ is H, or is Ci-6-alkyl, or is -(CO)-R^ wherein R"^ is: Ci-6-alkyl -(CH2)n-NR'R", R is is one or more of H, halo, or Ci-6-alkoxy optionally substituted by OH, or two R'^ may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; B is halo, CN, C]^-alkyl optionally substituted by CN or Ci-6-alkoxy, Ci^-alkoxy, C]-6-haloalkoxy, Cs-e-cycloalkyl, -C(0)0-Ci_6-aIkyl, -(CR"'R'')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, Ci_6-alkyl optionally substituted by CN or halo, C].6-aIkoxy; R' and R" are H, Ci.6-alkyl, Ci-6-alkyl-NR"'R*\ -C(0)-Ci^-alkyl, -S(0)2-Ci-6-alkyl or OH; R" and R'" are H or Ci^-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. 29. The compounds of formula (I-g) according to claim 27 or 28, wherein R^ is H or, -(CH2)m-R' wherein R' is aryl; R" is one or more of H or halo; R-^ is H, or is Ci-6-alkyl; R^ is H; R^ is H; as well as pharmaceutically acceptable salts thereof. 30. The compounds of formula (I-g) according to any one of claims 27 to 29, wherein said compounds are selected from the group consisting of (SS,RR)-r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; (RS,SR)-r-[(6-chloro-lH-indol-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; (RS,SR)-r-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3',5'-dimethyl-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one; and (lr3'R,5'S)-l'-[(l-benzyl-2-methyl-lH-indol-3-yl)carbonyl]-3',5'-dimethyI-3H-spiro[2-benzofuran-l,4'-piperidin]-3-one. 31. The compounds of formula (I-h) according to any one of claims 1 to 4: wherein R\ R^, R"*, R"*, R^ and X are as defined in any one of claims 1 to 4. 32. The compounds of formula (I-h) according to claim 31, wherein R^ is H, or is C]-6-alkyl optionally substituted by CN, or is sulfonylaryl, or is -(CH2)m-R^ wherein R^ is: OR', CN, NR*R", C3-6-cycloalkyl, 3 to 6 membered-heterocycloalkyl, aryl or 5 or 6 membered heteroaryl which are optionally substituted by one or more B, or is -(CH2)n-(C0>R^ wherein R*" is: Ci.6-alkoxy, NR*R", 6 membered-heterocycloalkyl, aryl, or 5 or 6 membered heteroaryl which are optionally substituted by one or more B; R^ is one or more of H, halo, Ci-6-alkyl; R" is H, or is Ci-6-alkyl, or is -(CO)-R^ wherein R"" is: Ci^-alkyl -(CH2)n-NR'R", R"^ is is one or more of H, halo, or Ci-6-alkoxy optionally substituted by OH, or two R"* may form an oxo or dioxo bridge together with the phenyl ring to which they are attached; R^ isHorCi.6-alkyl; X is CH2 or C=0; B is halo, CN, Ci-e-alkyl optionally substituted by CN or Ci-6-alkoxy, Ci^-alkoxy, Ci.6-haloalkoxy, Cs-e-cycloalkyl, -C(0)0-Ci^-alkyl, -(CR"'R'')n-phenyl, wherein the phenyl is optionally substituted by one or more substituent(s) selected from the group consisting of: halo, Ci.6-alkyl optionally substituted by CN or halo, Ci.6-alkoxy; R" and R'* are H, Ci^-alkyl, Ci_6-alkyl-NR"'R*^ -C(0)-Ci^-alkyl, -S(0)2-Ci-6-alkyl or OH; R''andR*'areHorCi^-alkyl; m is 1 to 6; n is 0 to 4; as well as pharmaceutically acceptable salts thereof. 33. The compounds of formula (I-h) according to claim 31 or 32, wherein R1 is H, or is -(CH2)n-(C0>Rb wherein Rb is NRiRii; R2 is one or more of H or halo; R3 is H; R4 is H; R8 isHorC1-6-alkyl; X is CH2 or C=0; Ri and Rii are H orC1-6-alkyl; as well as pharmaceutically acceptable salts thereof. 34. The compounds of formula (I-h) according to any one of claims 31 to 33, wherein said compounds are selected from the group consisting of r-[(6-chloro-lH-indol-3-yl)carbonyl]spiro[isoindole-l,4'-piperidin]-3(2H)-one; r-[(6-chloro-lH-indol-3-yl)carbonyl]-2-methyl-2,3-dihydrospiro[isoindole-l,4'-piperidine]; r-[(6-chloro-lH-indol-3-yl)carbonyl]-2,3-dihydrospiro[isoindole-l,4'-piperidine]; and 2-{6-chloro-3-[(3-oxo-2,3-dihydro-l'H-spiro[isoindole-l,4'-piperidin]-l'-yl)carbonyl]-lH-indol-l-yl}-N-methylacetamide. 35. A process for the preparation of the compounds of formula (I), (I-a), (I-b), (I- c), (I-d), (I-e), (I-f), (I-g) or (I-h) according to any one of claims 1 to 34 comprising the step of reacting a compound of formula (II): with a compound of formula A-H in order to obtain the compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h) wherein A, R1 R2 and R3 are as defined in any one of claims 1 to 34. 36. A process for the preparation of the compounds of formula (I), (I-a), (I-b), (I- c), (I-d), (I-e), (I-f), (I-g) or (I-h) according to any one of claims 1 to 34 comprising the step of reacting a compound of formula (III): with an electrophile compound of formula R^-Y in order to obtain the compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f). (I-g) or 0-h). wherein R\ R^ and R'^ are as defined in any one of claims 1 to 34 and Y is halo. 37. A process for the preparation of the compounds of formula (I), (I-a), (I-b), (I- c), (1-d), (I-e), (I-f), (I-g) or (I-h) according to any one of claims 1 to 34 comprising the step of reacting a compound of formula (IV): with an amine of formula HNR'R" in order to obtain the compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h), wherein R\ R\ R^ R* and R" are as defined in any one of claims 1 to 34. 38. A compound formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h) obtainable by a process according to any one of claims 35 to 37. 39. A compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h) according to any one of claims 1 to 34 for a use in the prevention or treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders. 40. A pharmaceutical composition comprising one or more compounds of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h) according to any one of claims 1 to 34 and a pharmaceutically acceptable carrier. 41. A pharmaceutical composition according to claim 40, wherein it is useful against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders. 42. Use of a compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (1-f), (I-g) or (I-h) according to any one of claims 1 to 34 for the preparation of a medicament. 43. Use according to claim 42, wherein the medicament is useful against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

Documents:

203-CHENP-2008 AMENDED PAGES OF SPECIFICATION 02-11-2011.pdf

203-CHENP-2008 AMENDED CLAIMS 02-11-2011.pdf

203-CHENP-2008 CORRESPONDENCE OTHERS 27-05-2011.pdf

203-CHENP-2008 EXAMINATION REPORT REPLY RECEIVED 02-11-2011.pdf

203-CHENP-2008 FORM-3 02-11-2011.pdf

203-CHENP-2008 OTHER PATENT DOCUMENT 02-11-2011.pdf

203-CHENP-2008 POWER OF ATTORNEY 02-11-2011.pdf

203-chenp-2008-abstract.pdf

203-chenp-2008-claims.pdf

203-chenp-2008-correspondnece-others.pdf

203-chenp-2008-description(complete).pdf

203-chenp-2008-form 1.pdf

203-chenp-2008-form 18.pdf

203-chenp-2008-form 26.pdf

203-chenp-2008-form 3.pdf

203-chenp-2008-form 5.pdf

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