Title of Invention

MICROEMULSION FORMULATIONS COMPRISING PARTICULAR SUBSTANCE P ANTAGONISTS

Abstract The present invention relates to dispersible pharmaceutical compositions in which the active agent is a substance P antagonist, in particular a 5-aryl-4(R)-arylcarbonylamino-pent 2-enoic acid amide, that is useful for the treatment and prevention of respiratory diseases including asthma and chronic obstructive pulmonary disease, bowel disorders including irritable bowel syndrome (IBS), urinary incontinence, and cough.
Full Text

Microemulsion formulations comprising particular substance P antagonists
The present invention relates to novel pharmaceutical compositions in which the active agent is a substance P antagonist, in particular a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide, that is useful for the treatment and prevention of respiratory diseases including asthma and chronic obstructive pulmonary disease, bowel disorders including irritable bowel syndrome (IBS), urinary incontinence, and cough.
5-aryl-4(R)-aryIcarbonylamino-pent-2-enoic acid amide substance P antagonists are a class of compounds described in international patent application WO 98/07694, the contents of which publication is incorporated herein by reference.
5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonists, such as those disclosed in WO 98/07694, present highly specific difficulties in relation to administration generally and galenic compositions in particular, including in particular problems of drug bioavailability and variability in inter- and intra-patient dose response, necessitating development of a non-conventional dosage form.
In accordance with the present invention it has now surprisingly been found that stable pharmaceutical compositions with 5-aryl-4(R)-aryIcarbonylamino-pent-2-enoic acid amide substance P antagonists, having particularly interesting bioavailability characteristics and reduced variability in inter- and intra-subject bioavailability parameters, are obtainable. These novel compositions have been found to meet or substantially reduce the difficulties encountered previously. It has been shown that the compositions of the invention may enable effective dosaging with concomitant enhancement of bioavailability as well as reduced variability of absorption/bioavailability levels for and between individual patients. Thus, the invention may achieve effective therapy with tolerable dosage levels of such 5-aryl-4(R.)-arylcarbonyiamino-pent-2-enoic acid amide substance P antagonists, and may permit closer standardization and optimization of daily dosage requirements for each individual. Consequently, occurrence of potential undesirable side-effects is diminished and overall cost of therapy may be reduced.

In a first aspect the present invention provides a spontaneously dispersible pharmaceutical composition comprising a 5-aryl-4(R)-arylcarbonyIamino-pent-2-enoic acid amide substance P antagonist.
The spontaneously dispersible pharmaceutical composition is hereinafter also referred to as a "composition of the invention". It is preferably a microemulsion preconcentrate.
Terms used in the specification have the following meanings:
"Active agent" as used herein means a 5-aryl-4(R)-arylc£rbonylamino-pexit-2-enoic acid amide substance P antagonist, such as those disclosed in WO 98/07694.
"Poorly water soluble11 as used herein means having a solubility in water at 20°C of less than 1%, for example 0.01 % weight/volume, i.e. a "sparingly soluble to very slightly soluble drug" as described in Remington: The Science and Practice of Pharmacy, 19th Edition, Ed. A.R. Gennaro, Mack Publishing Company, US, 1995, vol. 1, p 195.
"Bioavailable" as used herein with reference to a composition means the composition provides a maximum concentration of the active agent in that composition in a use environment that is at least 1.5 fold that of a control comprising an equivalent quantity of the undispersed drug.
"Spontaneously dispersible pharmaceutical composition" as used herein means a composition that contains an active agent herein defined and is capable of producing colloidal structures-when diluted with an aqueous medium, for example water, or in gastric juices. The colloidal structures can be solid or preferably liquid particles including droplets and nanoparticles. The spontaneously dispersible pharmaceutical composition is preferably a microemulsion preconcentrate.
"Microemulsion preconcentrate" as used herein means a composition which spontaneously forms a microemulsion in an aqueous medium, for example, in water, for example on dilunion of 1: 1 to 1: 300, preferably 1: 1 to 1: 70, but especially 1: 1 to 1: 10 or in the gastric juices after oral application.
"Microemulsion" as used herein means a slightly opaque, opalescent, non-opaque or substantially non-opaque colloidal dispersion that is formed spontaneously or substantially

spontaneously when its components are brought into contact with an aqueous medium. A microemulsion is thermodynamically stable and typically contains dispersed droplets of a mean diameter less than about 200 nm (2000 A). Generally microemulsions comprise droplets or liquid nanoparticles that have a mean diameter of less than about 150 nm (1500 A); typically less than 100 nm, generally greater than 10 nm, and they are stable over periods up to 24 hours.
Microemulsions offer greater ease of preparation due to spontaneous formation., thermodynamic stability, transparent and elegant appearance, increased drug loading, enhanced penetration through the biological membranes, increased bioavailability, and less inter- and mtra-individual variability in drug pharmacokinetics than coarse emulsions. Further characteristics of microemulsions can be found in United Kingdom patent specification GB 2,222,770; Rosof, Progress in Surface and Membrane Science, 12, 405 et seq. Academic Press (1975); Friberg, Dispeision Science and Technology, 6 (3), 317 et seq. (1985); and Muller et al. Pharm. Ind., 50 (3), 370 et seq. (1988)].
Throughout this specification and in the claims that follow, unless the context requires otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps
In a second aspect the present invention provides a spontaneously dispersible pharmaceutical composition comprising a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist as an active agent, and a carrier medium comprising a lipophilic component, a surfactant, and optionally a hydrophilic component.
Preferably the spontaneously dispersible pharmaceutical composition is suitable for oral administration.
The 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist is poorly water soluble as herein defined. It has a water solubility of below 0.001 %, e.g. 0.001 to 0.0001 %.
The active agent is preferably used in free base form.

In a third aspect the present invention provides a microemulsion preconcentrate comprising a 5-aryl-4(R)-aryIcarbonylamino-pent-2-enoic acid amide substance P antagonist.
In a fourth aspect the present invention provides a rxiicroemulsion preconcentrate comprising a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid s.mide substance P antagonist and a carrier medium that comprises a lipophilic component, a surfactant, and optionaUy a hydrophilic component.
The rnicroemulsion preconcentrate preferably forms an o/w (oil-in-water) rnicroemulsion when diluted with water.
Preferably the relative proportions of the lipophilic component(s), the hydrophilic components), and the surfactant(s) lie within the "Fvlicroemulsion" region on a standard three way plot graph. These phase diagrams, can be generated in a conventional manner as
described in e.g. GB 2,222,770 or WO 96/13273.
In a fifth aspect the present invention provides a rnicroemulsion comprising a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist.
The microemulsion is preferably an o/w (oil-in-wat&rj microemulsion.
In a sixth aspect the present invention provides a mLcroemulsion comprising a 5-aryl-4(R)-arylcarbonyIamino-pent-2-enoic acid amide substance P antagonist, a lipophilic component, a surfactant, water, and optionally a hydrophilic component.
The colloidal structures of the microemulsion form spontaneously or substantially spontaneously when the components of the composition of the invention are brought into contact with an aqueous medium, e.g. by simple shacking by hand for a short period of time, for example for 10 seconds. The compositions of the invention are thermodynamically stable, e.g. for at least 15 minutes or up to 4 hours, even to 24 hours. Typically, they contain dispersed structures, i.e. droplets or liquid nanopartlcles of a mean diameter less than about 200 nm (2,000 A), e.g. less than about 150 nm (1,500 A), typically less than 100 nm (1,000 A), generally greater than 10 nm (100 A) as measured by standard light scattering techniques, e.g. using a MALVERN ZETASIZER 3O00™ particle characterising machine.

Solid drug particles of mean diameter greater than 200 nm may also be present. The proportion of particles present may be temperature dependent.
The active agent is a neurokinin antagonist (NK antagonist) and is therefore capable of preventing disease symptoms that are caused inter alia by the activation of the NK1 receptor by substance P and the activation of the NK2 receptor by neurokinin A [=NKA]. The substance-P-antagonising effects can be demonstrated, for example, as follows: in vitro> for example, the binding of 3H-substance P to the bovine retina in the radio receptor assay according to H. Bittiger, Ciba Foundation Symposium 91 (1982) 196-199, is inhibited with IC50 values of from about 0.2 nM.
More specifically the active agent is a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist. This class of compounds is described in WO 98/07694,
Preferred active agents, which are described in WO 98/07694, include: (4R)-[Nt-methyl-N'-(3J5-bistrifluoromethyl-benzoyl)-amino]-5-(l-methyl-indol-3-7l)-pent-2-enoic acid N-[(R)-epsilon-caprolactam-3-yI]-amide,
(4R)-[N'-methyl-N'-(3:,5-bistrifluoromethyl-benzoyl)-amino]-5-(l-methyl-indol-3-7l)-pent-2-enoic acid N-[(S)-epsilon-caprolactam-3-yl]-amide5
(4R)-[N(-methyl-Nl-(3,5-bistrifluoromethyl-benzoyl)-amino]-5-(l-rnethyl-indol-3-7l)-pent-2-enoic acid N-cyclohexyl-amide,
(4R)-[N'-methyl-N'-(3:.5-bistrifluoromethyl-benzoyl)-amino]-5-(l-methyl-indol-3-yl)-2-methyl-pent-2-enoic acid N-cyclohexyl-amide,
(4R)-[N1-meth7l-N1-{3,5-bistrifluoromethyl-benzoyl)-amino]-5-(l-methyl-indol-3-yl)-2-methyl-pent-2-enoic acid N-[(R)-epsilon-caprolactam~3-yl]-amide, (4R)-[N1-methyl-Nl-(3;5-bistrifluoromethyl'benzoyl)-amino]-5-(l-methyI-indol-3-yl)-2-methyl-pent-2-enoic acid N-[(S)-epsiIon-caprolactam-3-yl]- amide,
(4R)-(N1-methyl-N1-benzoyl-ammo)-5-(l-methyI-indol-3-yl)-2-methyl-pent-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide,
(4R)-[N'-methyI-Nl-(3,5-bistrifluoromethyl-benzoyl)-amino]-5-(naphth-2-yl)-pent-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide,
(4R)-(N'-methyl-N1-benzoy])-amino-5-(naphth-2-yl)-pent-2-enoic acid N-[(R)-epsilon-caproIactara-3-ylj-amide,
(4R)-[N'-methyl-N'-(3,5-bistrifluoromethyl-benzoyl)-ammo]-5-(naphth-2-yl)-2-rnethyl-pent-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide,

(4R)-[N1-methyl-N'-(3,4,5-trimechox7-benzoyI)-amino]-5-(naphth-2-yl)-2-methyl-pent-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide,
(4R)-[N'-methyl-N'-(3;5-biscrifluoromethyl-benzoyl)-aimino]-5-(naphth-2-yl)-2-m^ 2-enoic acid N-[(S)-epsilon-caprolaccatn-3-yI]-amide5
(4R)-[N'-methyl-N1-(3,5-biscrifluoromerh)^benzoyl)-arnino]-5-(naphth-2-3d)-2-rnethyl-pent-2-enoic acid N-c3'cIohexyl-amide,
(4R)-[N1-methyI-N'-(3,5-bistrifluoromethyl-benzoyl)-arnino]-5-(l-methyl-mdol-3-yl)-pent-2-enoic acid N-[(S)-epsilon-caprolactam-3-yl]-amide,
(4R)-[Nl-methyl-Nl-(3,5-bistrifluoromethyl-benzoyl)-arnino]-4-(4-chlorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide,
(4R)-[N'-methyl-Nl-(3,5-bismfluoromethyl-benzoyl)-arnino]-4-(4-chlorobenzyl)-but-2-enoic acid N-[(S)-epsilon-caprolactam-3-yl]-amide,
(4R)-[N'-methyl-N'-(3J5-bistrifluoromethyl-benzoyl)-axnino]-4-(4-clilorobenzyl)-but-2-enoic acid N-cycIohexyl-amide,
(4R)-[N1-methyl-NI-(3,5-bistrifluoromechyl-benzoyl)-ariiino]-4-(3?4-dichloroberizyl)-but-2-enoic acid N-cyclohexyl-amide,
(4R)-[NI-meth3^1-N1-(3?5-bistrifluoromethyl-benzoyl)-ainaino]-4-(3)4-di£luorobenzyl)-but-2-enoic acid N-cyclohexyl-amide5
(4R)-fNt-methyl-N'-(3,5-bistnfiuoromethyl-benzoyl)-a3aimo]-5-(4-chlorophenyl)-2-methyi-pent-2-enoic acid N-cyclohexylamide,
(4R)4N'-methyl-Nt-(3)5-bistrifluoromethyl-benzoyl)-arnino]-5-(4-chlorophenyl)-2-rnethyl-pent-2-enoic acid N-[(R)-epsilon-caprolactam-3-yI]-arrLide,
(4R)4Nl-methyI-Nl-(3,5-bistrifluoromethyl-benzoyl)-arnmo]-4-(4-ch]orobenzyl)-2-inethyI-but-2-enoic acid [(S)-epsilon-caprolactam-3-yl]-amidej
(4R)-[N'-ethyl-N1-(3,5-bistrifluoromethyl-benzoyl)-amino]-5-(4-chlorophenyl)-pent-2-enoic acid N-[(S)-epsilon-caprolactam-3-yl]-amidej
(4R)-[N'-methyl-N'-(3,5-biEtrifluoromsthy]-benzoyl)-arnino]-5-(4-chlorophenyl)-3-methyl-pent-2-enoic acid N-cyclohexyl-amide.
(4R)-[N'-mechyl-Nt-(3,5-bisunfluoromechyl-benzoyl)-arnino]-4-(4-chlorobenzyl}-3-niethyl-but-2-enoic acid [(R)-epsi]on-caprolactam-3-yl]-amide,
(4R)-[N'-methyl-N1-(3.5-bistrifluoromeuhyl-benzoyl)-arnmo]-4-(4-chlorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-arnids,
(4R)-4-[N'-methyl-N'-(3,5-bistrifluoromethyl-benzoyI)-amino]-4-(3)4-dichlorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolacram-3-yl]-amide,

(4R)-and (4S)-4-[Nl-meth3d-N'-(3,5-bistri£luoromethyl-b&nzoyl)-amino]-4-(3-fluoro-4-
chlorobenzyl)-but-2-enoic acid N-[(R)-epsiIon-caprolactann-3-yI]-arnide3
(4R)-and (4S)-4-[N1-methyl-N1-(3,5-bistrifluorometh}d-b&nzoyl)-ainino]-4-(3)4-
difluorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolacta.m-3-yl]-amide,
(4R)-and (4S)-4-[N'-methyl-NI-(3J5-bistrifluoromethyl-b&nzoyI)-amino]-4-(3)4-
dibromobenzyI)-but-2-enoic acid N-[(R)-epsilon-caprolactarn-3-yl]-amide,
(4R)-and (4S)-4-[Nl-methyI-N'-(3,5-bistrifluoromethyl-beriizoyl)-ainino]-4-(3s455-
rrifluorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolactarn-3-yI]-arriide,
(4R)- and (4S)-4-jN1-methyi-N'-{3,5»bistrifluorometh3d-be:nzoyI)-ainiiio]-4-(4-fluorobenzyl)-
but-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide,
(4R)- and (4S)-[N!-(3,5-bistrifluoromethyl-benzoyl)-N'-methy]-arnino]-5,5-diphen7l-pent-2-
enoic acid N-[(S)-epsilon-caprolactam-3-yl]-amide,
(4S)-4-[N'-methyl-N'-(3,5-bistrifluoromethyIbenzoyl)amin.o]-4-(3)4-dichlorobenzyl)-but-2-
enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide,
(4R)-44N'-methyl-N>-(3?5-bistrifluoromethylbenzoyl)amino]-4-(3,4-dichlorobenzyl)-but-2'
enoic acid ^[(SJ-epsilon-caprolactam-S^n-amide, and
(4S)-4-[Ns-meth)d-N'-(3J5-bistri£luoromethyIbenzoyl)amiao]-4-(334-dichlorobenzyl)-but-2-
enoic acid N-[(S)-epsilon-caprolactam-3-yl]-amide.
The especially preferred active agent is (4R)-4-[NJ-methyl-3ST-(3,5-bistrifiuoro-methyl-benzoyl)amino]-4-(3j4-dichIorobenzyl)-but-2-enoic acid ]NT-[(R}-epsilon-caprolactain-3-yl]-amide, i.e. a compound of formula I

This compound is hereinafter referred to as Compound A.
The preferred and especially preferred active agents, in free or pharmaceutically acceptable salt form, may be prepared as described in international patent application WO 98/07694. As mentioned therein, they may be in the form of their hydrates and/or may include other solvents, for example solvents which may have been used f?or the crystallisation of compounds in solid form.

In accordance with the present invention the active agent may be present in an amount by weight of up to about 20% by weight of the composition of the invention, e.g. from about 0.05% by weight. The active agent is preferably present in an amount of 0.5 to 15 % by weight of the composition, more preferably in an amount of 1.5 to 5% by weight of the composition.
The active agent is poorly water soluble so it is carried in a carrier medium.
In some embodiments of the compositions of the invention the carrier medium comprises a lipophilic component and a surfactant. In other embodiments the carrier medium comprises a lipophilic component, a hydrophilic component and a surfactant.
The lipophilic component comprises one or more lipophilic substances. The hydrophilic component comprises one or more hydrophilic substances. And the carrier medium can contain one or more surfactants.
The compositions of the invention can include a variety of additives including antioxidants, antimicrobial agents, enzyme inhibitors, stabilizers, preservatives, flavours, sweeteners and further components such as those described in Fiedler, H. P. "Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik und angrenzende Gebiete", Editio Cantor, D-7960 Aulendorf, 4th revised and expanded edition (1996). These additives will conveniently be dissolved in the carrier medium.
The compositions of the invention include a lipophilic component or phase. The active agent may be contained in this component of the carrier medium.
The lipophilic component (when present) is preferably characterized by a low HLB value of less than 10, e.g. up to 8. Suitable lipophilic components include:
1) Glyceryl rnono-Cg-Cv-fattv acid esters
These are obtained esterifying glycerol with vegetable oil followed by molecular distillation. Monoglycerides suitable for use in the compositions of the invention include borh symmetric (i.e. fi-monoglycerides) as well as asymmetric monoglycerides
(a-monoglycerides. They also include both uniform glycerides (in which the fatty acid

constituent is composed primarily of a single fatty acid) as well as mixed glycerides (i.e. in which the fatty acid constituent is composed of various fatty acids) The fatty acid constituent may include both saturated and unsaturated fatty acids ha_*ving a chain length of e.g. CB-CH. Particularly suitable are caprylic or lauric acid monoglycerides which are commercially available, e.g. under the trade names Imwitor® 3O8 or Imwitor® 312, respectively, from e.g. sasol. For example Imwitor® 308 comprises at least 80 % monoglycerides and exhibits the following additional characterising data: free glycerol max 6 %, acid value max. 3, saponification value 245-265, iodine value max. 1, water content max. 1 %. Typically it comprises 1 % free glycerol, 90 % monoglycerides, 7 % diglycerides> 1 % triglycerides (H. Fiedler, Joe. cit., volume 1, page 798). A further example is Capmul MCM C8 from Abitec Corporati on.
Mixtures of mono- and di-glvcerides of Q-Cut fatty acids
These include both symmetric (i.e. 15-monoglycerides and a^-diglycerides) as well as asymmetric mono- and di-glycerides (i.e. a-monoglycerides and a,Jl-digIycerides) and acetylated derivatives thereof. They also include both uniform glycerides (in which the fatty acid constituent is composed primarily of a single fatty acid) as well a_s mixed glycerides (i.e. in which the fatty acid constituent is composed of various fatty acids) and any derivatives thereof with lactic or citric acid. The fatty acid constituent may include both saturated and unsaturated fatty acids having a chain length of" from e.g. CB-CIO. Particularly suitable are mixed caprylic and capric acid mono- and di-glycerides as commercially available, e.g. under the trade name Imwitor® ~P42 or Imwitor 928, from e.g. sasol. For example Imwitor® 742 comprises at least 45% monoglycerides and exhibits the following additional characterising data: free glycerol max. 2 %, acid value max. 2, saponification value 250-280, iodine value nax. 1, water max. 2 % (H. Fiedler, he. dt.> vol 1, page 798). Other suitable mixfures comprise mono/diglycerides of caprylic/capric acid in glycerol as known an d commercially available under e.g. the trade name Capmul® MCM from e.g. Abitec Corporation. Capmul® MCM exhibits the following additional characterising data: acid value 2.5 max., alpha-Mono (as oleate) 80% min., free glycerol 2.5% max., iodine value 1 max., chain length distribution: caproic acid (C6) 3% max., caprylic acid (C8) 75% rnin., capric acid (C10) 10% min., lauric acid (C12) 1.5% max., moisture (by Karl Fisher) 0.5% max. (manufacturer information). Suitable^ examples of mono-/di-glcyerides with additional derivatization with lactic or citric acrid are those marketed under the brand names of Imwitor 375, 377 or 380 by sasol. Furthermore,

the fatty acid constituent may include both saturated and unsarurared fatty acids having a chain length of from e.g. CIS-CIB, A suitable example is Tegin® O (glyceryl oleate) exhibiting the following additional characterising data: monoglyceride content 55-65%) peroxide value max. 10, water content max. 1%, acid value max. 2, iodine value 70-76, saponification value 158-175, free glycerol max. 2%, (manufacturer information).
GIvcervl di- Q-Qr B-fattv acid esters
These include symmetric (i.e. cLjCiMiglycerides) and asymmetric diglycerides (i.e. a,JJ-diglycerides) and acetylated derivatives thereof. They also include both uniform glycerides {in'which the fatty acid constituent is composed primarily of a single fatty acid) as well as mixed glycerides (i.e. in which the fatty acid constituent is composed of various fatty acids) and any acetylated derivatives thereof. The fatty acid constituent can include both saturated and unsaturated fatty acids having a chain length of from Cg-Cis.e.g. Cs-Citf, e.g. Cg-Cio, e.g. C$. Particularly suitable is caprylic diglycerides, which is commercially available, e.g. under the trade name Sunfat® GDC-S, e.g. from Taiyo Kagaku Co., Ltd. Sunfat® GDC-S has an acid value of about 0.3, a diglyceride content of about 78.8%, and a monoester content of about 8.9.
Medium chain fatty acid triglyceride
These include triglycerides of saturated fatty acid having 6 to 12, e.g. 8 to 10, carbon atoms. Suitable medium chain fatty acid triglycerides are those known and commercially available under the trade names Acomed®, Myritol®, Captex®, Neobee®M 5 F, Miglyol®810, Miglyol®812, Miglyol®818s Mazol®, Sefsol®860, Sefsol®870; Miglyol®812 being the most preferred. Miglyol®812 is a fractionated coconut oil comprising caprylic-capric acid triglycerides and having a molecular weight of about 520 Daltons. Fatty acid composition = Ce max. about 3%, Cs about 50 to 65%, Cio about 30 to 45%, C12 max 5%; acid value about 0.1; saponification value about 330 to 345; iodine value max 1. Miglyol® 812 is available from Condea. Neobee® M 5 F is a fractionated caprylic-capric acid triglyceride available from coconut oil; acid value max. 0.2; saponification value about 335 to 360; iodine value max 0.5, water content max. 0,15%, D.20 0,930-0,960, nD20 1,448-1,451 (manufacturer information). Neobee® M 5 F is available from Stepan Europe. A further example is Miglyol 829 containing additionally esters with succinic acid.

Glvcervl mono-Cu-Cis-fattv acid esters
These are obtained esterifying glycerol with vegetable oil followed by molecular distillation. Monoglycerides suitable for use in the compositions of the invention include both symmetric (i.e., 6-monoglycerides) as well as asymmetric monoglycerides (a-monoglycerides. They also include both uniform glycerides (in which the fatty acid constituent is composed primarily of a single fatty acid) as well as mixed, glycerides (i.e. in which the fatty acid constituent is composed of various fatty acids) The fatty acid constituent may include both saturated and unsaturated fatty acids Ihaving a chain length of from e.g. C16-C1&. Suitable examples include GMOrphic by Estrman, Rylo MG20 distilled monoglyceride by Danisco Ingredients, or Monomuls 9O-O18 by Henlcel. For example GMOrphic®-S0 (glyceryl monooleate) exhibits th& following additional characterising data: monoglyceride content min. 94%, C18:l content 75% min., peroxide value max. 2.5, C18:2 + Cl8:3 max. 15%, C16:0 + C18: 0 + C20:0 max. 10%, water max. 2%, acid value max. 3, iodine value 65-75, sapomification value 155-165, free glycerine max. 1%, hydroxyl number 300-330 (manufacturer information).
Mixed mono-, dk tri-glycerides
These include mixed mono-, di-, tri-glycerides that are commercially available under the trade name Maisine® from Gattefosse. They are transesterification products of corn oil and glycerol. Such products are comprised predominantly of linoleic and oleic acid mono-, di- and tri-glycerides together with minor amounts of palmmc and stearic acid mono-, di- and tri-glycerides (corn oil itself being comprised of ca. 56% by weight linoleic acid, 30% oleic acid, ca. 10% palmitic and ca. 3% stearic acid constituents). Physical characteristics are: free glycerol max 10%, monoglycerides ca. Mixed mono-, di-. tri-glycerides preferably comprise mixtures of Ci to C10 or C12-20 fatty acid mono-, di- and tri-glycerides, especially mixed Cis-is fatty acid mono-, di-and triglycerides. The fatty acid component of the mixed mono-, di- and tri-glycerides

may comprise both saturated and unsaturared fatty acid residues. Preferably however they are predominantly comprised of unsaturated fatty acid residues; in particular CIB unsaturated fatty acid residues. Suitably the mixed mono-, di-, tri-glycerides comprise at least 60%, preferably at least 75%, more preferably at least 85% by weight of a Cis unsaturated fatty acid (for example linolenic, linoleic and oleic acid) mono-, di- and tri-glycerides. Suitably the mixed mono-, di-, tri-glycerides comprise less than 20%, for example about 15% or 10% by weight or less, saturated fatty acid (for example palmitic and stearic acid) mono-, di- and'tri-glycerides. Mixed mono-, di-, tri-glycerides are preferably predominantly comprised of mono- and di-glycerides; for example mono- and di-glycerides comprise at least 50%, more preferably at least 70% based on the total weight of the lipophilic phase or component. More preferably, the mono- and di-glycerides comprise at least 75% (for example about 8O% or 85% by weight of the lipophilic component. Preferably monoglycerides comprise from about 25 to about 50%, based on the total weight of the lipophilic component, of the mixed mono-, di-, tri-glyceiides. More preferably from about 30 to about 4-0% (for example 35 to 40%) monoglycerides are present. Preferably diglycerides comprise from about 30 to about 60%, based on the total weight of the lipophilic component, of the mixed mono-, di-, tri-glycerides. More preferably from about 40 to about 5*5% (for example 48 to 50%) diglycerides are present. Triglycerides suitably comprise at least 5% but less than about 25 %, based on the total weight of the lipophilic component, of the mixed mono-, di-, tri-glycerides. More preferably from about 7.5 to about 15% (for example from about 9 to 12%) triglycerides are present. Mixed mon_o-, di-, tri-glycerides may be prepared by admixture of individual mono-, di- or tri-glycerides in appropriate relative proportion. Conveniently however they comprise trans-esterification products of vegetable oils, for example almond oil, grouind nut oil, olive oil, peach oil, palm oil or, preferably, corn oil, sunflower oil or safflower oil and most preferably corn oil, with glycerol. Such transesterification products a~re generally obtained as described in GB 2 257 359 or WO 94/09211. Preferably some of the glycerol is first removed to give a "substantially glycerol free batch" when soft gelatine capsules are to be made. Purified transesterification products of corn oil and glycerol provide particularly suitable mixed mono-, di-, and tri-glycerides hereinafter referred to as "refined oil" and produced according to procedures described in United Kingdom patent specification GB 2,257,359 or international patent publication WO 94/09211.
Acetylated monoglvcerides (C18)

These include Myvacet 9-45.
Propvlene glycol monofattv acid esters
The farcy acid constituent may include both saturated and unsaturated fatty acids having a chain length of from e.g. CB-CU- Particularly suitable are propylene glycol mono ester of caprylic and lauric acid as commercially available, e.g. under the trade names Sefsol® 218, Capryol®90 or Lauroglycol®90, from e.g. Nikko Chemicals Co., Ltd. or Gattefosse or Capmul PG-8 from Abitec Corporation. For example Lauroglycol®90 exhibits the following additional characterising data: acid value max. 8, saponification value 200-220, iodine value max. 5, free propylene glycol content max. 5%, monoester content min. 90%; Sefsol® 218 exhibits the following additional characterising data: acid value max. 5, hydroxy value 220-280 (H. Fiedler, loc. dt., vol 25 page 906, manufacturer information).
Propvlene grlvcol mono- and di- fatty acid esters These include Laroglycol FCC and Capryol PGMC.
Propylene glycol diesters
Propylene glycol di-fatty acid esters such as propylene glycol dicaprylate (which is commercially available under the trade name Miglyol® 840 from e.g. sasol; H. Fiedler, loc. at., volume 2, page 1008) or Captex 200 from Abitec Corporation.
Propvlene glycol monoacetate and propvlene glycol diacetate
Transesterified ethoxylated vegetable oils
These include transesterified ethoxylated vegetable oils such as those obtained by reacting various natural vegetable oils (for example, maize oil, kernel oil, almond oil, ground nut oil. olive oil, soybean oil, sunflower oil, safflower oil and palm oil, or mixtures thereof) with polyethylene glycols that have an average molecular weight of from 200 to 800;, in the presence of an appropriate catalyst. These procedures are described in United States patent specification US 3,288,824. Transesterified ethoxylated corn oil is particularly preferred.
Transesterified ethoxylated vegetable oils are known and are commercially available
under the trade name Labrafil® (H. Fiedler, loc, cit., vol 2, page 880). Examples are

Labrafil® M 2125 CS (obtained from corn oil and having an acid value of less than about 2, a saponification value of 155 to 175, an HLB value of 3 to 4, and an iodine value of 90 to 110). and Labrafil® M 1944 CS (obtained from kernel oil and having an acid value of about 2, a saponification value of 145 to 175 and an iodine value of 60 to 90). Labrafil® M 2130 CS (which is a transesterification product of a Cms glyceride and polyethylene glycol and which has a melting point of about 35 to 40°C, an acid value of less than about 2, a saponification value of 185 to 200 and an iodine value of less than about 3) may also be used. The preferred transesterified echoxylated vegetable oil is Labrafil® M 2125 CS which can be obtained, for example, from Gattefosse, Saint-Priest Cedex, France.
Sorbitan fatty acid esters
Such esters include e.g. sorbitan mono Cms fatty acid esters, or sorbitan tri Cn-is fatty acid esters are commercially available under the trade mark Span® from e.g. uniqema. An especially preferred product of this class is e.g. Span® 20 (sorbitan monolaurate) or Span® 80 (sorbitan monooleate) (Fiedler, loc. dt9 2, p. 1430; Handbook of Pharmaceutical Excipients, loc. tit., page 473).
Esterified compounds of fatty acid and primary alcohols
These include esterified compounds of fatry acid having 8 to 20 carbon atoms and primary alcohol having 2 to 3 carbon atoms, for example, isopropyl myristate, isopropyl palmitate, ethyl linoleate, ethyl oleate, ethylmyristate etc., with an esterified compound of linoleic acid and ethanol being particularly preferable, also isopropylmyristat and isopropylpalmitat.
Glvcerol triacetate or (1.2.3)-triacetin
This is obtained by esterifying glycerin with acetic anhydride. Glycerol triacetate is commercially available as, e.g. Priacetin® 1580 from Unichema International, or as Eastman™ Triacetin from Eastman, or from Courtaulds Chemicals Ltd. Glycerol triacetate exhibits the following additional characterising data: molecular weight 218,03, D.20>3 1,159-1,163, nD2D 1,430-1,434, water content max. 0.2 %,-viscosity (25°) 17.4 mPa s; acid value max. 0.1. saponification value of about 766-774, criacetin content 97% min. (H. Fiedler, loc. cit.. vol 2, page 1580; Handbook of Pharmaceutical Excipients, loc. cit.. page 534, manufacturer information).

Acervl methyl citrate
This is obtained by esterification of citric acid and ethanol, followed by acetylation with acetic anhydride, respectively. Acetyl triethyl citrate is commercially available, e.g. under the trade name Citrofiex® A-25 from e.g. Morflex Inc.
Tributylcitrate or acetvl tributyl citrate
Polyglycerol fatty acid esters
These have for example from 2 to 10, e.g. 6 glycerol units. The fatty acid constituent can include both saturated and unsaturated fatty acids having a chain length of from e.g. CB-CIB. Particularly suitable is e.g. Plurol Oleique CC497 from Gattefosse, having a saponification value of 133-155 and a saponification value of 196-244. Further suitable polyglycerol fatty acid esters include diglyceryl monooleate (DGMO) and HexagIyn-5-O, as known and commercially available from e,g. Nikko Chemicals Co., Ltd.
PEG-fattv alcohol ether
This includes Brij 30™ polyoxyethylene(4) lauryl ether.
Fatnr alcohols and fatty acids
Fatty acids can be obtained by hydrolysing various animal and vegetable fats or oils, such as olive oil, followed by separation of the liquid acids. The fatty acid/alcohol constituent can include both saturated and mono- or di-unsaturated fatty acids/alcohols having a chain length of from e.g, Q-C20. Particularly suitable are, e.g. oleic acid, oleyl alcohol, linoleic acid, capric acid, caprylic acid, caproic acid, tetradecanol, dodecanol, or decanol. Oleyl alcohol is commercially available under the trade mark HD-Eutanol® V from e.g. Henkel KGaA. Oleyl alcohol exhibits the following additional characterising data: acid value max 0.1, hydroxy value of about 210, iodine value of about 95> saponification value max 1, D.20 about 0,843, nD20 1,462, molecular weight 268, viscosity (20°) about 35 mPa s (manufacturer information). Oleic acid exhibits the following additional characterising data: molecular weight 282,47, D.2D 0,895, nD201,45823, acid value 195-202, iodine value 85-95, viscosity (25°) 26 mPa s (H. Fiedler, loc, cit.: volume 2, page 1112; "Handbook of Pharmaceutical Excipients", 2nd Edition, Editors A. Wade and P. J. Weller (1994),

Joint publication of American Pharmaceutical Assoc, Washington, USA and The Pharmaceutical Press, London, England, page 325).
I Tocopherol and its derivatives (e.g. acetate)
These include Coviox T-70, Copherol 1250, Copherol F-1300, Covitol 1360 and Covitol 1100.
Pharmaceuticallv acceptable oils
Alternatively the lipophilic component comprises e.g. a pharmaceutically acceptable
oil, preferably with an unsaturated component such as a vegetable oil.
Alkylene polvol ethers or esters
These include C^alkylene triols, in particular glycerol, ethers or esters. Suitable C3-
salkylene triol ethers or esters include mixed ethers or esters, i.e. components including
other ether or ester ingredients, for example transesterification products of C3.
5alkylene triol esters with other mono-, di- or poly-ols. Particularly suitable alkylene
polyol ethers or esters are mixed Cs-salkylene trioI/poly-(C2-4alkylene) glycol fatty acid
esters, especially mixed glycerol/polyethylene- or polypropylene-glycol fatty acid esters.
Especially suitable alkylene polyol ethers or esters include products obtainable by transesterification of glycerides, e.g. triglycerides, with poly-(C2-4alkylene) glycols, e.g. poly-ethylene glycols and, optionally, glycerol. Such transesterification products are generally obtained by alcoholysis of glycerides, e.g. triglycerides, in the presence of a po!y-(C-2-4alkylene) glycol, e.g. polyethylene glycol and, optionally, glycerol (i.e. to effect transesterification from the glyceride to the poly-alkylene glycol/glycerol component, i.e. via poly-alkylene glycolysis/glycerolysis). In general such reaction is effected by reacting the indicated components (glyceride, polyalkylene glycol and, optionally, glycerol) at elevated temperature under an inert atmosphere with continuous agitation.
Preferred glycerides are fatty acid triglycerides, e.g. (Cio-zzfatty acid) triglycerides, including natural and hydrogenated oils, in particular vegetable oils. Suitable vegetable oils include, for example, olive, almond, peanut, coconut, palm, soybean and wheat germ oils and, in particular, natural or hydrogenated oils rich in (Cia-isfatty acid) ester residues. Preferred polyalkylene glycol materials are polyethylene glycols, in particular polyethylene glycols having a molecular weight of from ca. 500 to ca. 4,000, e.g. from ca. 1,000 to ca. 2.000.

Suitable alkylene polyoi ethers or esters include mixtures of C3-5alkylene triol esters, e.g. mono-, di- and tri-esters in variable relative amount, and poly (C2^alkylene) glycol mono- and di-esters, together with minor amounts of free C3.jalkylene triol and free poly-fGwalkylene) glycol. As hereinabove set forth, the preferred alkylene triol moiety is glyceryl; preferred polyalkylene glycol moieties include polyethylene glycol, in particular having a molecular weight of from ca. 500 to ca. 4,000; and preferred fatty acid moieties will be Cio-izfatty acid ester residues, in particular saturated Cio-^fatty acid ester residues.
Particularly suitable alkylene polyol ethers or esters include transesterification products of a natural or hydrogenated vegetable oil and a polyethylene glycol and, optionally, glycerol; or compositions comprising or consisting of glyceryl mono-, di-and tri-Cio-nfatty acid esters and polyethylene glycol mono- and di- Qo^fatty esters (optionally together with, e.g. minor amounts of free glycerol and free polyethylene glycol).
Preferred vegetable oils, polyethylene glycols or polyethylene glycol moieties and fatty acid moieties in relation to the above definitions are as hereinbefore set forth.
Particularly suitable alkylene polyol ethers or esters as described above for use in the present invention include those commercially available under the trade name Gelucire® from e.g. Gattefosse, in particular the products:
a) Gelucire® 33/01, which has an m.p. = ca. 33-37DC and a saponification value of
ca. 230-255;
b) Gelucire® 39/01, m.p. = ca. 37.5-41.5GC, saponification v. = ca. 225-245;
c) Gelucire® 43/01, m.p. = ca. 42-46°C, saponification v. = ca. 220-240;
Products (a) to (c) above all have an acid value of maximum of 3. The compositions of the invention may include mixtures of such ethers or esters.
Hydrocarbons
These include e.g. squalsne. available from e.g. Nikko Chemicals Co., Ltd.
Erhvlene glycol esters

These include Monthyle® (echylene glycol monostearate), available from e.g. Gattefosse.
26) Pentaerythriol fattv acid esters and polvalkvlene glvcol ethers
These include, for example pentaerythrite-dioleate, -distearate, -monolaurate, -polyglycol ether, and -monostearate as well as pentaerythrite-fatty acid esters (Fiedler, loc. at., 2, p. 1158-1160, incorporated herein by reference).
Some of these, e.g. (1-3, 5-6, 8-9, 12-13,19), display surfactant-like behaviour and may also be termed co-surfactants.
The lipophilic component (when present) preferably comprises 5 to 85 % by weight of the composition of the invention, e.g. 10 to 85%; preferably 15 to 60 % by weight, more preferably about 20 to about 40 % by weight.
For those embodiments where the carrier medium comprises a hydrophilic component in addition to the lipophilic component and the surfactant the relative proportions of the lipophilic component(s), hydrophilic component(s) and the surfactant(s) lie within the "Microemulsion" region on a standard three way plot graph.
The compositions of the invention may include a hydrophilic component or phase. Suitable hydrophilic compounds include:
1) Polyethylene glycol glyceryl Cg-Cm fattv acid esters
The fatty acid ester may include mono and/or di and/or tri fatty acid esters. It optionally includes both saturated and unsaturated fatty acids having a chain length of from e.g. Cs-Cio. The polyethylene glycols may have e.g. from 5 to 10 [CH2-CH2-O] units, e.g. 7 units. A particularly suitable fatty acid ester is polyethylene glycol (7) glyceryl monococoate, which is commercially available, e.g. under the trade name Cetiol® HE, e.g. from Henkel KGaA. Cetiol® HE has a D. (20D) of 1.05, an acid value of less than 5, a saponification value of about 95, a hydroxyl value of about 180 and an iodine value of less than 5 (H. Fiedler, loc. cit., vol 1, page 337) or Lipestrol £-810.
2) N-a.ikvlpvrrolidone

Particularly suitable is, e.g. N-Methyl-2-pyrrolidone, e.g. as commercially available under the trade name Pharmasolve™, from e.g. International Specialty Products (ISP). N-methylpyrrolidone exhibits the following additional characterising data: molecular weight 99,1, D.25 1,027-1,028, purity (as area % by GC) (including Methyl Isomers) 99.85% min (H. Fiedler, loc. at., vol 2, page 1004, manufacturer information).
Benzyl alcohol
This is commercially available from e.g. Merck or may be obtained by distillation of benzyl chloride with potassium or sodium carbonate. Benzyl alcohol exhibits the following additional characterising data: molecular weight 108,14, D. 1,043-1,049, nD 1,538-1,541. (H. Fiedler, loc. dt., vol 1, page 238; Handbook of Pharmaceutical Excipients, loc. cit, page 35).
Triethvl citrate
It is obtained esterifying citric acid and ethanol. Triethyl citrate is commercially available, e.g. under the trade names Citroflex® 2, or in a pharmaceutical grade under the name TEC-PG/N, from e.g. Morflex Inc. Particularly suitable is triethyl citrate which has molecular weight of 276,3, a specific gravity of 1,135-1,139, a refractive index of 1,439-1,441, a viscosity (25°) of 35,2 mPa s, assay (anhydrous basis) 99,0-100?5 %, water max. 0?25 % (Fiedler, H. P., loc. cit.,, vol 1, page 371; "Handbook of Pharmaceutical Excipients", loc. cit., page 540).
Other suitable hydrophilic compounds include transcutol (C2H5-[O-(CH;i)2]2-OH)5 glycofurol (also known as tetrahydrofurfuryl alcohol polyethylene glycol ether), 1,2-propylene glycol, dimethylisosorbide (Arlasolve), polyethylene glycol, triethylenglycol, ethylacetate, and ethyllactate.
The hydrophilic component may comprise 5 to 60 % by weight of the composition of the
invention, e.g. 10 to 50%: preferably 10 to 40 % by weight, more preferably about 10 to about 30% by weight.
The hydrophilic component may comprise a mixture of two or more hydrophilic components.

The compositions of the invention may lower alkanols such as ethanol as a hydrophilic co-componeni. While the use of ethanol in the compositions is not essential, it has been found to be of particular advantage when the compositions are to be manufactured in soft gelatine, encapsulated form. This is because storage characteristics are improved, in particular the risk of active agent precipitation following encapsulation procedures is reduced. Thus the shelf life stability may be extended by employing ethanol or some other such co-component as an additional ingredient of the composition. The ethanol may comprise 0 to 60 % by weight of the composition; preferably 5 to about 30% by weight and more preferably about 5 to 20 % by weight.
The compositions of the present invention preferably contain one or more surfactants to reduce the interfacial tension thereby providing thermodynamic stability. Surfactants may be complex mixtures containing side products or unreacted starting products involved in the preparation thereof, e.g. surfactants made by polyoxyethylation may contain another side product, e.g. polyethylene glycol. The or each surfactant preferably has a hydrophilic-lipophilic balance (HLB) value of 8 to 17, especially 10 to 17. The HLB value is preferably the mean HLB value.
Suitable surfactants include:
1) Reaction products of a natural or hydrogenated castor oil and ethvlene oxide
The natural or hydrogenated castor oil may be reacted with ethylene oxide in a molar ratio of from about 1:35 to about 1:60, with optional removal of the polyethylene-glycol component from the products. Various such surfactants are commercially available. Particularly suitable surfactants include polyethyleneglycol-hydrogenated castor oils available under the trade name Cremophor®; Cremophor® RH 40, which has a saponification value of about 50 to 60, an acid value less than about 1, a water content (Fischer) less than about 2%. an nD60 of about 1.453-1.457 and an HLB of about 14-16; and Cremophor® RH 60, which has a saponification value of about 40-50; an acid value less than about 1, an iodine value of less than about 1, a water content (Fischer) of about 4.5-5.5%, an nD60 of about 1.453-1.457 and an HLB of about 15 to 17.
An especially preferred product of this class is Cremophor® RH40. Other useful
products of this class are available under the trade names Nikkol® (e.g. Nikkol®

HCO-40 and HCO-60), Mapeg® (e.g. Mapeg® CO-40h)5 Incrocas® (e.g. Incrocas® 40), Tagac® (for example polyoxyethylene-glycerol-fatty acid esters e.g. Tagat® RH 40) and Simulsol OL-50 (PEG-40 castor oil, which has a saponification value of about 55 to 65, an acid value of max. 2, an iodine value of 25 to 35, a water content of max. 8%, and an HLB of about 13, available from Seppic). These surfactants are further described in Fiedler loc. cit
Other suitable surfactants of this class include polyethyleneglycol castor oils such as that available under the trade name Cremophor® EL, which has a molecular weight (by steam osmometry) of about 1630, a saponification value of about 65 to 70, an acid value of about 2, an iodine value of about 28 to 32 and an no25 of about 1.471.
Polyoxyethvlene-sorbitan-fatty acid esters
These include mono- and tri-lauryl, palmityl, stearyl and oleyl esters of the type known
and commercially available under the trade name Tween® (Fiedler, loc. at. p.1615 ff)
from Uniqema including the products:
Tween® 20 [polyoxyethylene(20)sorbitanmonolaurate],
Tween® 21 [polyoxyethylene(4)sorbitanmonolaurate],
Tween® 40 [polyoxyethylene(20)sorbkanmonopalmitate],
Tween® 60 [polyoxyethylene(20)sorbitanmonostearate]?
Tween® 65 [polyoxyethylene(20)sorbitantristearate],
Tween® 80 [polyoxyethylene(20)sorbitanmonooleate],
Tween® 81 fpolyoxyethylene(5)sorbitanmonooleate]? and
Tween® 85 [polyoxyethylene(20)sorbitantrioleate].
Especially preferred products of this class are Tween® 20 and Tween® 80.
Poivoxvethvlene fatty acid esters
These include polyoxyethylene stearic acid esters of the type known and commercially available under the trade name Myrj® from Uniqema (Fiedler, loc. cit., 2, p. 1042). An especially preferred product of this class is Myrj® 52 having a D25 of about 1.1., a melting point of about 40 to 44°C3 an HLB value of about 16.9., an acid value of about 0 to 1 and a saponification no. of about 25 to 35.
Polyoxyethvlene-polyoxypropylene co-polymers and block co-polymers or poloxamers

These include the type known and commercially available under the trade names Pluronic® and Emkalyx® (Fiedler, loc. dt^ 2, p, 1203). An especially preferred product of this class is Pluronic® F6S (poloxamer 188) from BASF, having a melting point of about 52°C and a molecular weight of about 6800 to 8975. A further preferred product of this class is Synperonic® PE L44 (poloxamer 124) from Uniqema.
Polyoxyethylene mono esters of a saturated Cm to Cn
These include Cis substituted e.g. hydroxy fatty acid; e.g. 12 hydroxy stearic acid PEG ester, e.g. of PEG about e.g. 600-900 e.g. 660 Daltons MW, e.g. Solutol® HS 15 from BASF, Ludwigshafen, Germany. According to the BASF technical leaflet MEF 151E (1986) comprises about 70% polyethoxylated 12-hydroxystearate by weight and about 30% by weight unesterified polyethylene glycol component. Solutol HS 15 has a hydrogenation value of 90 to 110, a saponification value of 53 to 63, an acid number of maximum 1, and a maximum water content of 0.5% by weight.
Polyoxyethylene alkvl ethers
These include polyoxyethylene glycol ethers of C12 to Cis alcohols, e.g. Polyoxyl 2-, 10- or 20-cecyl ether or Potyoxyl 23-Iauryl ether, or polyoxyl 20-oleyl ether, or Polyoxyl 2-? 10-, 20- or 100-stearyl ether, as known and commercially available e.g. under the trade mark Brij® from Uniqema. An especially preferred product of this class is e.g. Brij® 35 (Polyoxyl 23 lauryl ether) or Brij® 98 (Polyoxyl 20 oleyl ether) (Fiedler, loc. rit., 1, pp. 259; Handbook of Pharmaceutical Excipients, loc. d£.5 page 367). Similarly suitable products include polyoxyethylene-polyoxypropylene-alkyl ethers, e.g. polyoxyethylene-polyoxypropylene- ethers of C12 to CIB alcohols, e.g. polyoxyethylen-20-polyoxypropy-lene-4-cetylether which is known and commercially available under the trade mark Nikkol PBC® 34, from e.g. Nikko Chemicals Co., Ltd. (Fiedler, loc. at, vol. 2. pp. 1239). Polyoxypropylene fatty acid ethers, e.g. Acconon® E are also suitable.
Sodium alkvl sulfates and sulfonates. and sodium alkvl aryl sulfonates
These include sodium lauryl sulfate, which is also known as sodium dodecyl sulfate
and commercially available, e.g. under the trade name Texapon K12® from Henkel
KGaA.
Water soluble tocopheryl polyethylene glvcol succinic acid esters (TPGS)

These include rhose with a polymerisation number ca 1000, e.g. available from Eastman Fine Chemicals Kings-port, Texas, USA.
Polyglycerol fatty acid esters
These include chose with e.g. from 10 to 20, e.g. 10 glycerol units. The fatty acid constituent may include both saturated and unsarurated fatty acids having a chain length of from e.g. CB-CIB. Particularly suitable is e.g. decaglyceryimonolaurat or decaglycerylmonomyristat, as known and commercially available under the trade mark Decaglyn® 1-L or Decaglyn® 1-M or Decaglyn l-O, respectively, from e.g. Nikko Chemicals C, Ltd (Fiedler, loc. at,, vol. 2, pp. 1228).
Alkylene polyol ethers or esters
These include C3-5alkylene triols, in particular glycerol, ethers or esters. Suitable C3. 5alkyiene triol ethers or esters include mixed ethers or esters, i.e. components including other ether or ester ingredients, for example transesterification products of C3. jalkylene triol esters with other mono-, di- or poly-ols. Particularly suitable alkylene poiyol ethers or esters are mixed C3-5alkylene triol/poly-(C^alkylene) glycol fatty acid esters, especially mixed glycerol/polyethylene- or polypropylene-glycol fatty acid esters.
Especially suitable alkylene polyol ethers or esters include products obtainable by transesterification of glycerides. e.g. trigtycerides, with po]y-(C2-4alkylene) glycols, e.g. poly-ethylene glycols and, optionally, glycerol.
Such transesterification products are generally obtained by alcoholysis of glycerides, e.g. triglycerides, in the presence of a poly-(C-2-4alkylene) glycol, e.g. polyethylene glycol and, optionally, glycerol (i.e. to effect transesterification from the glyceride to the poly-alkylene glycol/glycerol component, i.e. via poly-alkylene glycolysis/gly-cerolysis). In general such reaction is effected by reacting the indicated components (glyceride, polyalkylene glycol and, optionally, glycerol) at elevated temperature under an inert atmosphere with continuous agitation.
Preferred glycerides are fatty acid triglycerides, e.g. (CiD-22fatty acid) triglycerides, including natural and hydrogenated oils, in particular vegetable oils. Suitable vegetable oils include, for example, olive, almond, peanut, coconut, palm, soybean and wheat

germ oils and, in particular, natural or hydrogenated oils rich in (Cn-isfatty acid) ester residues.
Preferred polyalkylene glycol materials are polyethylene glycols, in particular polyethylene glycols having a molecular weight of from ca. 500 to ca. 4,000, e.g. from ca. 1,000 to ca. 2,000.
Suitable alkylene polyol ethers or esters include mixtures of C3-jalkylene triol esters, e.g. mono-, di- and tri-esters in variable relative amount, and poly (C2-4alkylene) glycol mono- and di-esters3 together with minor amounts of free C3-5alkylene triol and free poly-(C2-5alkylene) glycol. As hereinabove set forth5 the preferred alkylene triol moiety is glyceryl; preferred polyalkylene glycol moieties include polyethylene glycol, in particular having a molecular weight of from ca. 500 to ca. 4,000; and preferred fatty acid moieties will be Cio-22fatty acid ester residues, in particular saturated Cio-22fatry acid ester residues.
Particularly suitable alkylene polyol ethers or esters include transesterification products of a natural or hydrogenated vegetable oil and a polyethylene glycol and, optionally, glycerol; or compositions comprising or consisting of glyceryl mono-, di-and tri-Cio-oifatty acid esters and polyethylene glycol mono- and di- Cicmfatty esters (optionally together with, e.g. minor amounts of free glycerol and free polyethylene glycol).
Preferred vegetable oils, polyethylene glycols or polyethylene glycol moieties and fatty acid moieties in relation to the above definitions are as hereinbefore set forth.
Particularly suitable alkylene polyol ethers or esters as described above for use in the present invention include those commercially available under the trade name Gelucire® from e.g. Gattefosse, in particular the products:
a) Gelucire® 44/14. m.p. = ca. 42.5-47.5DC, saponification v. = ca. 79-93;
b) Gelucire® 50/13, m.p. = ca. 46-51°C, saponification v. = ca. 67-81;
Produces (a) to (b) above all have an acid value of maximum of 2.

Alkylene polyol ethers or esters having an iodine value of maximum 2 are generally preferred. The compositions of the invention may include mixtures of such ethers or esters.
Gelucire® products are inert semi-solid waxy materials with amphiphilic character. They are identified by their melting point and their HLB value. Most Gelucire® grades are saturated polyglycolised glycerides obtainable by polyglycolysis of natural hydro-genated vegetable oils with polyethylene glycols. They are composed of a mixture of mono-, di- and tri-glycerides and mono- and di-fatty acid esters of polyethylene glycol. Particularly suitable is Gelucire® 44/14 which has a nominal melting point of 44DC and an HLB of 14. It is obtained by reacting hydrogenated palm kernels and/or hydrogenated palm oils with polyethylene glycol 1500. It consists of approximately 20 % mono-, di- and triglycerides, 72 % mono- and di- fatty acid esters of polyethylene glycol 1500 and 8% of free polyethylene glycol 1500. The fatty acid distribution for Gelucire® 44/14 is as follows: 4-10 Cs> 3-9 Cio, 40-50 Cu, 14-24 d4, 4-14 Ci6, 5-15 Cis. Gelucire® 44/14 exhibits the following additional characterising data: acid value of max. 2, iodine value of max. 2, saponification value of 79-93, hydroxyl value of 36-56, peroxide value of max. 6, alkaline impurities max. 80, water content max. 0.50, free glycerol content max. 3, monoglycerides content 3.0-8.0. (H. Fiedler, loc. cit., vol 1, page €76; manufacturer information).
Polyethylene glycol glycervl fatty acid esters
The fatty acid ester may include mono and/or di and/or tri fatty acid ester. The fatty acid constituent may include both saturated and unsaturated fatty acids having a chain length of from e.g. Cn-Cu. The polyethylene glycols may have e.g. from 10 to 40 [CH2-CH2-O] units, e.g. 15 or 30 units. Particularly suitable is polyethylene glycol (15) glyceryl monostearat which is commercially available, e.g. under the trade name TGMS®-15; e.g. from Nikko Chemicals Co., Ltd. Other suitable glyceryl fatty acid esters include polyethylene glycol (30) glyceryl monooleate which is commercially available, e.g. under the trade name Tagat® O, e.g. from Goldschmidt (H. Fiedler, loc. at.3 vol. 2, p. 1502-1503), and Tagat 02 (polytheylene glycol (20) glycerol monooieate. as well as Tagat L (polytheylene glycol (30) glycerol monolaurate) and Tagat L2 (polytheylene glycol (20) glycerol monolaurate), all e.g. from Goldschmidt (H. Fiedler, loc. cit., vol. 2, p. 1502-1503). A further suitable polyethylene glycol slvceryl fatty acid ester is Ta^at TO.

Sterols and derivatives thereof
These include cholesterols and derivatives thereof, in particular phytosterols, e.g. products comprising sitosterol, campesterol or stigmasterol, and ethylene oxide adducts thereof, for example soya sterols and derivatives thereof, e.g. polyethylene glycol sterols., e.g. polyethylene glycol phytosterols or polyethylene glycol soya sterols. The polyethylene glycols may have e.g. from 10 to 40 [CH2-CH2-O] units, e.g. 25 or 30 units. Particularly suitable is polyethylene glycol (30) phytosterol which is commercially available, e.g. under the trade name Niklcol BPS®-30, e.g. from Nikko Chemicals Co., Ltd. Further suitable is polyethylene glycol (25) soya sterol which is commercially available, e.g. under the trade name Generol® 122 E 25, e.g. from Henkel (H. Fiedler, loc. tit., vol. 1, p. 680).
Transesterified. polyoxyethylated caprylic-capric acid glvcerides These include those that are commercially available under the trade name Labrasol® from e.g. Gattefosse. Labrasol® has an acid value of max, 1, a saponification value of 90-110, and an iodine value of max. 1 (H. Fiedler, loc, ctt., vol 2, page 880).
Sugar fatty acid esters
These include those of Cn-Cu fatty acids, e.g. sucrose monolaurate, e.g. Ryoto L-1695(5), which is commercially available from e.g. Mitsubishi-Kasei Food Corp., Tokyo, Japan.
PEG scerol ethers
These include those having, e.g. from 5 to 35 [CH2-CH2-O] units, e.g. 20 to 30 units.,
e.g. Solulan® C24, which is commercially available from e.g. Amerchol.
Dioctylsodiumsulfosuccinate
This is commercially available under the trade mark Aerosol OT® from e.g. American Cyanamid Co. (Fiedler, loc. at., I, p. 118), or di-[2-ethylhexyl]-succinate (Fiedler, loc. city volume 1, p. 487).
Phospholipids
These include in particular lecithins (Fiedler, loc. cit, volume 2, p. 910,1184).
Suitable lecithins include, in particular, soya bean lecithins.

Salts of fattv acids, fatty acid sulfates and sulfonates
These include those of e.g. Cg-Cig, fatty acids, -fatty acid sulfates and sulfonates, as
known and commercially available from e.g. Fluka.
Salts of acylated amino acids
These include those of Ce-Cis, acylated amino acids, e.g. sodium lauroyl sarcosinate,
which is commercially available from e.g. Fluka.
Medium or long-chain alkvl. e.g. Cg-Cn, ammonium salts
These include Cg-Cis acylated amino acids e.g. cetyl trimethyl ammonium bromide,
which is commercially available from e.g. E. Merck AG.
The surfactant may comprise 5 to 90 % by weight of the composition of the invention; preferably 15 to 85 % by weight, more preferably 20 to 60 % by weight and even more preferably between about 35 % and about 55 % by weight.
Certain embodiments of the compositions of the invention include additives for example antioxidants, antimicrobial agents, enzyme inhibitors, stabilizers, preservatives, flavours, sweeteners and other components such as those described in Fiedler, H. P., loc. at.
Preferred antioxidants include ascorbyl palmkate, butyl hydrox7 anisole (BHA), butyl hydroxy toluene (BHT) and tocopherols. The antioxidant ct-tocopherol (vitamin E) is especially preferred.
These additives or ingredients may comprise about 0.05 to 5% by weight of the total weight of the composition. Antioxidants, antimicrobial agents, enzyme inhibitors, stabilizers or
preservatives typically provide up to about 0.05 to 1% by weight based on the total weight of the composition. Sweetening or flavouring agents typically provide up to about 2.5 or
5% by weight based on the total weight of the composition.
The aforementioned additives can also include components that solidify a liquid micro-emulsion pre-concentxate (MEPC). These include solid polyethylene glycols (PEGs) and Gelucire™ products, preferably those such as like Gelucire™ 44/14 or Gelucire™ 50/13 that function as additional surfactants.

In a seventh aspecr the invention provides a process for preparing a spontaneously dispersible pharmaceutical composition containing a 5-aryI-4(R)-aryIcarbonylamino-pent-2-enoic acid amide substance P antagonist as an active agents which process comprises bringing the active agent and a carrier medium comprising (1) a lipophilic component, (2) a surfactant, and optionally (3) a hydrophilic component into intimate admixture.
The carrier medium can be prepared separately before bringing the active agent into intimate admixture with the carrier medium. Alternatively the two or more of the components of the carrier medium can be mixed together with the active agent.
The spontaneously dispersible pharmaceutical composition is preferably a microemulsion preconcentrate as herein defined.
The spontaneously" dispersible pharmaceutical composition preferably spontaneously or substantially spontaneously forms an o/w (oil-in-water) emulsion, e.g. microemulsion, when diluted with an aqueous medium such as water to a dilution of 1:1 to 1:300, e.g. 1:1 to 1:70, especially 1:10 to 1:70, more especially e.g. 1:10, or in the gastric juices of a patient after oral application.
In an eighth aspect the invention provides a process for the preparing a microemulsion
containing a 5-aiyl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist
as an active agent, which process comprises:
(ij bringing the active agent and a carrier comprising (1) a lipophilic component, (2) a surfactant, and optionally (3) a hydrophilic component into intimate admixture to form a spontaneously dispersible pharmaceutical composition; and
(ii) diluting the spontaneously dispersible pharmaceutical composition in an aqueous medium to form the microemulsion.
As mentioned above, the active agent may be present in an amount by weight of up to about 20% by weight of the composition of the invention, e.g. from about 0.05% by weight, The active agent is preferably present in an amount of 0. J to 15 % by weight of the composition, more preferably in an amount of 1.5 to 5% by weight of the composition.

The lipophilic component preferably comprises 5 to 85 % by weight of the composition of the invention, e.g. 10 to 85%; preferably 15 to 60 % by weight, more preferably about 20 to about 40 % by weight.
The hydrophilic component (when present) may comprise 5 to 60 % by weight of rhe composition of the invention, e.g. 10 to 50%; preferably 10 to 40 % by weight, more preferably about 10 to about 30% by weight. It may comprise a mixture of two or more hydrophilic components. The ratio of main hydrophilic component to hydrophilic co-component is typically from about 0.5:1 to about 2: 1.
The surfactant may comprise 5 to 90% by weight of the composition of the invention; preferably 15 to 85% by weight, more preferably 20 to 60 % by weight and even more preferably between about 35% and about 55% by weight.
The relative proportion of the active agent(s), the lipophilic component(s), the surfactant(s) and the r^drophilic component(s) (when present) preferably lie within the "Microemulsion" region on a standard three way plot graph. The compositions will therefore be of high stability rhat are capable, on addition to an aqueous medium, of providing microernulsions, for example having a mean particle size of When the composition of the invention is a micro emulsion preconcentrate it may be combined with water or an aqueous solvent medium to obtain an emulsion, for example a microemulsion. The emulsion or microemulsion may be administered enterally, for example orally, for example in the form of a drinkable solution.
When the composition of the invention is a microemulsion preconcentrate a unit dosage of the microemulsion preconcenrrate is preferably used to fill orally administrable capsule shells. The capsule shells may be soft or hard capsule shells, for example made of gelatine. Each unit dosage will suitably contain from 0.1 to 100 mg active agent, for example 0.1 mg, 10 mg, 15 mg, 25 mg or 50 mg5 preferably between 10 and 100 mg of the active agent, more preferably between 10 and 50 mg: for example 15, 20, 25, or 50 mg, more preferably between 5 and 20 mg. most preferably 5 or 10 mg. Such unit dosage forms are suitable for administration 1 zo 5 times daily depending upon the particular purpose of therapy, the phase of therapy and the liice. However, if desired, the compositions may be in drink solution form and may include water or any other aqueous system, e.g. fruit juice, milk, and

the like, to provide e.g. colloidal systems, suitable for drinking, e.g. with a dilution of from about 1:10 to about 1:1 00.
The compositions of the invention, e.g. those in the examples hereinafter, may show good stability characteristics as indicated by standard stability trials, for example having a shelf life stability of up to one, two or three years, and even longer. One group of compositions of the invention may be of high stability that are capable, on addition to water, of providing aqueous microemulsions having an average particle size of The compositions of the invention exhibit especially advantageous properties when administered orally; for example in terms of consistency and high level of bioavailability obtained in standard bioavaiiability trials.
Pharrnacokinetic parameters, for example drug substance absorption and measured for example as blood levels, also become surprisingly more predictable and problems in administration with erratic absorption may be eliminated or reduced. Additionally the pharmaceutical compositions are effective with biosurfactants or tenside materials, for example bile salts, being present in the gastro-intestinal tract. That is, the pharmaceutical compositions of the present invention are fully dispersible in aqueous systems comprising such natural tensides and thus capable of providing emulsion or microemulsion systems and/or particulate systems in situ which are stable. The function of the pharmaceutical compositions upon oral administration remain substantially independent of and/or unimpaired by the relative presence or absence of bile salts at any particular time or for any given individual. The compositions of this invention may also reduce variability in inter- and intra-patient dose response.
The utility of the compositions of the invention may be observed in standard clinical tests in, for example, known indications of active agent at dosages giving therapeutically effective active agent blood levels. Any increased bioavailability of the compositions of the invention may be observed in standard animal tests and in clinical trials.
The dose of the active agent in the compositions of the invention is of the same order as, or up to half, that used in known compositions containing the active agent. The compositions of the invention show activity at concentrations from about 0. 1 mg to about 40 mg/day of

active agent, preferably from about 0. 1 mg to about 20 mg/day, e.g. most preferably from about 0.1 to about 3 mg/day of active agent for respiratory disease states.
The compositions of the invention are useful for the treatment of respiratory diseases, e.g. asthma and chronic bronchitis. For these indications, the appropriate dosage will, of course, vary depending upon, for example, the particular composition of the invention employed, the host, the mode of administration, and the nature and severity of the conditions being
treated.
A typical dose for the active agent is from 0. 1 to 1 mg/day for asthma and chronic bronchitis.
Thus in a ninth aspect the present invention provides a method of treatment of a subject suffering from a disorder treatable with a 5-aryl-4(R)-arylcarbonyIamino-pent-2-enoic acid amide substance P antagonist comprising administering a therapeutically effective amount of a pharmaceutical composition of the invention to a subject in need of such treatment.
The invention is illustrated by the following Examples.

EXAMPLES
In the following examples the phannaceutically active agent is Compound A i.e. (4R)-4-[N'-
meth3d-N'-(3,5-bistnfluoro-rnethyl-benzo7l)arnino]-4-(3,4-dichlorobenzyl)-but-2-enoic acid
N-[(R)-epsilon-caprolactam-3-yl]-amide.
Example 1
Filled capsule (or oral solution)
The formulation contains:
Compound A 20 mg
Cremophor RH 40 215 mg
C8/C10mono-/ 130 mg
diglyceride
Triethylcitrate 85 mg
Ethanol 50 mg
Example 2
Filled ..capsule (or oral solution) The formulation contains:
Compound A 10 mg
Cremophor RH 40 219 mg
Corn oil glycerides 174 mg
Propyleneglycol 27 mg
Ethanol 75 mg
Tocopherol 0.5 mg
Example 3 Oral solution
The formulation contains:
Compound A 10 mg/ml
Cremophor RH 40 439 mg
Corn oil glycerides 343 mg
Propyleneglycol S8 mg
Ethanol 99 mg
Tocopherol 1.0 mg

The compositions of all three examples are prepared whereby the carrier components are mixed and the active ingredient is dissolved therein whilst stirring. The mixtures of the formulation of Examples 1 and 2 are filled into hard gelatine capsules and sealed using the Quali-Seal™ sealing technique.
Similarly, further examples are prepared as follows:
Excipients mg/1 g
Cremophor RH40 423
Corn oil glycerides 253.8
PEG400 169.2
Ethanol 94
Compound A 60
Cremophor RH40 423
Corn oil glycerides 253.8
Triethylcitrate 169.2
Ethanol 94
Compound A 60
Cremophor RH40 418.5
C8/C10 mono-/diglycerides 251.1
PEG400 167.4
Ethanol 93
Compound A 70
Cremophor RH40 400.5
C8/C10 mono-/diglycerides 240.3
Propylene glycol 160.2
Ethanol 89
Compound A 110

Cremophor RH40 480
CS/C10 mono-/dig]ycerides 288
Trierhylcitrac 192
Compound A 40
PEG-20 glyceryl oleat 380
C8/C10 mono-/digiycerides 285
Triethylcitrate 190
Ethanol 95
Compound A 50
Cremophor RH40 432
Propylene glycol
monocaprylace 345.6
Span 80 86.4
Tri ethyl citrate 96
Compound A 40
Cremophor RH40 405
CS/C10 mono-/dig]ycerides 180
Propylene glycol
monocaprylate ISO
Ethanol 135
Compound A 100
Cremophor RH40 405
C8/C10 mono-/diglycerides 180
Propylene glycol
monocaprylate 90
Triethylcitrare 90

Ethanol 135
Compound A 100
Crernophor EL 480
Capryol % 288
Triethylcitrat 152
Compound A 40
No phase separation or precipitation observed for any of the above compositions which are clear for at least 4 hours.
2. Bioavailability
..Bioavailability analysis of Example 1 in a dog study shows, that single peroral doses of 20 mg Compound A given as standard capsule formulation using micronized DS (formulation A) resulted in significantly lower plasma levels of Compound A (-50%) than given as microemulsion (formulation B). For illustration of the data see table below and figure on page
1/1,.

SUBSTITUTE SHEET (RULE 26)

3. Embodiment:
In general for our microemulsions the most preferred embodiment are soft gelatine capsules. This is due to the fact that a number of microemulsion excipients e.g. propylene glycolj are incompatible with hard gelatin capsules making them brittle. Soft gelatine capsules contain a large amount of softener and therefore compatibility is better.


CLAIMS
1. A spontaneously dispersible pharmaceutical composition comprising a 5-aryl-4(R)-
arylcarbonylamino-pent-2-enoic acid amide substance P antagonist.
2. A spontaneously dispersible pharmaceutical composition comprising a 5-aryl-4(R)-
arylcarbonylamino-pent-2-enoic acid amide substance P antagonist and a carrier medium
comprising a lipophilic component, a surfactant, and optionally a hydrophilic component.
3. A pharmaceutical composition as claimed in claim 1 or 2 where the 5-aryl-4(R)-
arylcarbonykmino-pent-2-enoic acid amide substance P antagonist is (4R)-4-[N!-methyl-N*-
(3,5-bistrifluoro-methyl-benzoyl)amino]-4-(3;4-dichlorobenzyl)-but-2-enoic acid N-[(R)-
epsilon-caprolactam-3-yl]-amide.
4. A pharmaceutical composition comprising (4R)-4-[N'-methyl-N'-(3,5-bistri£luoro-
methy]-benzoyl)amino]-4-(3j4-dichlorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolactam-
3-yl]-amide as active agent and a carrier medium comprising a lipophilic component, a
surfactant and optionally a hydrophilic component, said composition being in an form that
is suitable for oral administration.
5. A composition as claimed in claim 2 or 4 wherein the lipophilic component
comprises Cg-Cio fatty acid monoglycerides and diglycerides or a refined glycerol-
transesterified corn oil.
6. A composition as claimed in any one of claims 2, 4 and 5 wherein the hydrophilic
component comprises propylene glycol.
7. A composition as claimed in any one of claims 2, 4, 5 and 6 wherein the surfactant
comprises a polyethyleneglycol-hydrogenated castor oil.
8. A spontaneously dispersible pharmaceutical composition comprising about 0.05 to
about 20% by weight of (4R)-4-[N'-methyl-N>-(3,5-bistrifluoro-methyl-benzoyl)aniino]-4-
(3,4-dichlorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide, about 5 to
about 85 % by weight of a lipophilic component, about 5 to about 90 % by weight of a

surfactant, and optionally about 5 to about 60 % by weight of a hydrophilic component, all weights based on the total composition.
9. A composition as claimed in any one of claims 1 to 8 in the form of a microemulsion
preconcentrate.
10. A composition as claimed in any one of claims 1 to 8 in the form of a
microemulsion.
11. A composition according to any preceding claim in unit dosage form.
12. A composition according to claim 11 in soft or hard gelatin encapsulated form.
13. A method of treatment of a subject suffering from a disorder treatable with a 5-aryl-
4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist comprising
administering a therapeutically effective amount of a pharmaceutical composition as claimed
in any preceding claim to a subject in need of such treatment.
14. A process for preparing a spontaneously dispersible pharmaceutical composition
containing a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist
as an active agent, which process comprises bringing the active agent and a carrier medium
comprising (1) a lipophilic component, (2) a surfactant, and optionally (3) a hydrophilic
component into intimate admixture.
15. A process for the preparing a microemulsion containing a 5-aryl-4(R)-arylcarbonyl-
amino-pent-2-enoic acid amide substance P antagonist as an active agent, which process
comprises:
(i) bringing the active agent and a carrier comprising (1) a lipophilic component, (2) a surfactant, and optionally (3) a hydrophilic component into intimate admixture to form a spontaneously dispersible pharmaceutical composition; and
(ii) diluting the spontaneously dispersible pharmaceutical composition in an aqueous medium to form the microemulsion.

16. A spontaneously dispersible pharmaceutical composition comprising a 5-aryl-4(R)-arylcarbonylamino-pent-2-enoic acid amide substance P antagonist substantially as herein described with reference to any one of the Examples.


Documents:

2872-CHENP-2006 CORRESPONDENCE OTHERS 14-03-2011.pdf

2872-CHENP-2006 AMENDED PAGES OF SPECIFICATION 05-12-2011.pdf

2872-CHENP-2006 AMENDED CLAIMS 05-12-2011.pdf

2872-CHENP-2006 CORRESPONDENCE OTHERS 08-12-2011.pdf

2872-CHENP-2006 FORM-3 05-12-2011.pdf

2872-CHENP-2006 FORM-3 08-12-2011.pdf

2872-CHENP-2006 OTHER PATENT DOCUMENT 08-12-2011.pdf

2872-CHENP-2006 POWER OF ATTORNEY 05-12-2011.pdf

2872-CHENP-2006 CORRESPONDENCE PO.pdf

2872-CHENP-2006 EXAMINATION REPORT REPLY RECEIVED 05-12-2011.pdf

2872-CHENP-2006 FORM-18.pdf

2872-chenp-2006-abstract.pdf

2872-chenp-2006-claims.pdf

2872-chenp-2006-correspondnece-others.pdf

2872-chenp-2006-description(complete).pdf

2872-chenp-2006-drawings.pdf

2872-chenp-2006-form 1.pdf

2872-chenp-2006-form 26.pdf

2872-chenp-2006-form 3.pdf

2872-chenp-2006-form 5.pdf

2872-chenp-2006-pct.pdf


Patent Number 250919
Indian Patent Application Number 2872/CHENP/2006
PG Journal Number 06/2012
Publication Date 10-Feb-2012
Grant Date 07-Feb-2012
Date of Filing 04-Aug-2006
Name of Patentee NOVARTIS AG
Applicant Address Lichtstrasse 35, CH-4056 Basel
Inventors:
# Inventor's Name Inventor's Address
1 LUCKEL, Barbara Dinkelbergstrasse 6, 79540 Lorrach
2 BUEB, Waltraud Hausmattweg 10, CH-4663 Aarburg
3 OTTINGER, Isabel Maria-Folhrenbach-Strasse 7, 79111 Freiburg
4 REINHART, Thomas Stettengasse 29, 79540 Lorrach
5 RIES, Angelika Blauenweg 10, CH-4224 Nenzlingen
PCT International Classification Number A61K9/107
PCT International Application Number PCT/EP2005/001166
PCT International Filing date 2005-02-04
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 0402679.5 2004-02-06 U.K.