Title of Invention

TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY

Abstract

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Full Text

TR1AZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY RELATED -APPLICATIONS This application claims the benefit of U.S. Provisional Application No. 60/628.P79, filed November 18, 2004; U.S. Provisional Application No. 60/709,358. filed August 18, 2005, and U.S. Provisional Application No. 60/725,044, filed October* 6, 2005. The entire teachings of the above applications are incorporated herein by reference. BACKGROUND OF THE INVENTION Although tremendous advances have been made in elucidating the genomic abnormalities that cause malignant cancer ce'ls, currently available chemotherapy remains -unsatisfactory, and the prognosis for the majority of patients diagnosed with cancer remains dismal. Most chemotherapeutic agents act on a specific molecular target thought to be involved in the development of the malignant phenotype. However, a complex network of signaling pathways regulate cell proliferation, and the majqrity of malignant cancers are facilitated by multiple genetic abnormalities in these pathway. Therefore, it is unlikely that a therapeutic agent that acts on one molecular target will be fully effective in curing a patient who has cancer. Heat shock proteins (HSPs) are a class of chaperone proteins that are upregulatecl in response :o elevated temperature and other environmental stresses, such as ultraviolet light, nutrient deprivation, and oxygen deprivation. HSPs act as chaperones to other cellular proteins (called client proteins) and facilitate their proper folding and repair, and aid in the refolding of misfolded client proteins. There art several known families of HSPs, each having its own set of client proteins. The Hsp90 family is one of the most abundant HSP families, accounting for about 1- 2% of proteins in a cell that is not under stress and increasing to about 4-6% in a ceil under strjess. Inhibition of Hsp90 results in degradation of its client proteins via the ubiquitin proteasome pathway. Unlike other chaperone proteins, the client proteins of Hsp9Q are mostly protein kinases or transcription factors involved in signal transduction, and a number of its client proteins have been shown to be involved in the progression of cancer. Examples of Hsp90 client proteins that have been implicated in the progression of cancer are described below. Her-2 is a transmembrane tyrosine kinase cell surface growth factor receptor that is expressed in normal epithelial cells. Her2 has an extracellular domain that interacts with extracellular growth factors and an internal tyrosine kinase portion that transmits the external growth signal to the nucleus of the cell. Her2 is overexpressed in a significant proportion of malignancies, such as breast cancer, ovarian cancer, prostate cancer, and gastric cancers, and is typically associated with a poor prognosis. c-Kit is a membrane receptor protein tyrosine kinase which binds Stem Cell Factor (SCF) to its extraellular domain. c-Kit is involved in the development of melanocytes, mast, germ and hematopoietic cells, and there is evidence that it plays a role in several types of cancer including leukemias, mast cell tumors, small cell lung cancer, testicular cancer, cancers of the gastointesinal tract and cancers of the central nervous system. c-Met is a receptor tyrosine kinase that is encoded by the Met protooncogene and transduces the biological effects of hepatocyte growth factor (HGF), which is also referred to as scatter factor (SF). Jiang et al., Crit. Rev. Oncol. Hemtol. 29: 209- 248 (1999), the entire teachings of which are incorporated herein by reference, c- Met and HGF are expressed in numerous tissues, although their expression is normally confined predominantly to cells of epithelial and mesenchymal origin, respectively. c-Met and HGF are required for normal mammalian development and have been shown to be important in cell migration, cell proliferation and survival, morphogenic differentiation, and organization of 3-dimensional tubular structures (e.g., renal tubular cells, gland formation, etc.). The c-Met receptor has been shown to be expressed in a number of human cancers. c-Met and its ligand, HGF, have also been shown to be co-expressed at elevated levels in a variety of human cancers (particularly sarcomas). However, because the receptor and ligand are usually expressed by different cell types, c-Met signaling is most commonly regulated by tumor-stroma (tumor-host) interactions. Furthermore, c-Met gene amplification, mutation, and rearrangement have been observed in a subset of human cancers. Famiiies with germine mutations that actuate c-Mct kinase are prone to multiple kidney tumors as \vell as tumors in other tissues. Numerous studies have correlated the expression of c-Met and/or HGF/SF with the state of disease progression of different types of cancer (including lung, colon, breast, prostate, liver, pancreas, brain, kidney, ovaries, stomach, skin, and bone cancers). Furthermore, the overexpression of c-Met or HGF have been shown to correlate with poor prognosis and disease outcome in a number of major human cancers including lung, liver. gastric, and breast. Akt kinase is a serine/threonine kinase which is a downstream effector molecule of phosphoinositide 3-kinase and is involved in protecting the cell from apoptosis. Akt kinase is thought to be involved in the progression of cancer because it stimulates cell proliferation and suppresses apoptosis. Cdk4/cyclin D complexes are involved in phosphorylation of retinoblastcma protein which is an essential step in progression of a cell through the Gl phase of the cell cycle. Disruption of Hsp90 activity has been shown to decrease the half life of newly synthesized Cdk4. Raf-1 is a MAP 3-kinase (MAP3K) which when activated can phosphor- late and acitivate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. The transforming protein of Rous sarcoma virus,v-src, is a prototype of an oncogene family that induces cellular transformation (i.e., tumorogenesis) by nonregulated kinase activity. Hsp90 has been shown to complex with v-scr and inhibit its degradation. The BCR-ABL fusion protein associated with chronic myelogenous leukemia and in a subset of patients with acute lymphoblastic leukemia. The fusion protein is a consequence of exchange of genetic material from the long arms of chromosomes 9 and 22 and results in unregulated tyrosine kinase activity. BCRABL exists as a complex with Hsp90 and is rapidly degraded when the action of Hsp90 is inhibited. Hsp90 is required to maintain steroid hormone receptors in a conformation capable of binding hormone with high affinity. Inhibition ofthe action of HspPO therefore is expected to be useful in treating hormone-associated malignancies such as breast cancer. :p53 is a tumor suppressor protein that causes cell cycle arrest and apoptosis. Mutation of the p53 gene is found in about half of all human cancers making it one of the most common genetic alterations found in cancerous cells. In addition. p53 mutation is associated with a poor prognosis. Wild-type p53 has been shown to interact with Hsp90, but mutated p53 forms a more stable association than wild-type p53 as a result of its misfolded conformations. A stronger interaction with Hsp90 protects the mutated protein form normal proteolytic degradation and prolongs its half-life. In a cell that is heterozygous for mutated and wild-type p53, inhibition of the stabilizing effect of Hsp90 causes mutant p53 to be degraded and restores the normal rranscriptional activity of wild-type p53. Hif-la is a hypoxia-inducible transcription factor thai is up-regulated under low oxygen conditions. Under normal oxygen conditions Hif-la associates with Von Hippel-Lindau (VHL) tumor suppressor protein and is degraded. Low oxygen conditions inhibits this association and allows Hif-la to accumulate and complex with Hif-lp to form an active transcription complex that associates with hypo.viarespon$ e elements to activate the transcription of vascular endothelial growth factor (VEGF). Increased Hif-la is associated with increased metastasis and a poor prognosis. Hsp90 has been shown by mutational analysis to be necessary for the survival of normal eukaryotic cells. However. Hsp90 is over expressed in many tumor types indicating that it may play a significant role in the survival of cancer cells and that cancer cells may be more sensitive to inhibition of Hsp90 than normal cells. For example, cancer cells typically have a large number of mutated and overexpressed oncoproteins that are dependent on Hsp90 for folding. In addition, because the environment of a tumor is typically hostile due to hypoxia, nutrient deprivation, acidosis, etc., tumor cells may be especially dependent on Hsp90 for survival. Moreover, inhibition of Hsp90 causes simultaneous inhibition of a number of oncoproteins. as well as hormone receptors and transcription factors making it an attractive target for an anti-cancer agent. In fact, benzoquinone ansamycins, a family of natural products that inhibit Hsp90. has shown evidence of therapeutic activity in clinical trials. Although promising, bcnzoquinone ansamycins, and their derivatives, suffer from a number of limitations. For example, they have low oral bioavailabiliry. and their limited solubility makes them difficult to formula. In addition, they are metabolized by polymorphic cytochrome P450 CYP3A4 and are a substrate for Pglycoprotein export pump involved in the development of multidrug resistance. Therefore, a need exist for new therapeutics that improve the prognosis of cancer patients and that rccuces or overcomes the limitations of currently used anti-cancer agents. SUMMARY OF THE INVENTION The presen: invention provides novel compounds which inhibit the activity of Hsp90 and are useful in the treatment of proliferative disorders, such as cancer. The present invent:cm also provides new uses for previously disclosed compounds. The presen: invention provides compounds having the formula (I): (Figure Removed) and tautomers, phi-maceutically acceptable salts, solvates, clathrates. and procrugs thereof. In formula 11), ring A is an aryl or a heteroaryl, wherein the aryl or the heteroaryl are optimally further substituted with one or more substituents in addition to R3; R, is -OH. -SH, -NR7H, -OR26, -SR26, -NHR26> -O(CH2)mOH, -0(CH2)mSH, -0(.CH2)mNR7H, -S(CH2)mOH, -S(CH2)mSH, -S(CH2)mNR-H. -OC(Q)NR,0Ru, -SC(O)NRloRn, -NR7C(O)NR,0R,,, -OC(O)R7, -SC(0)R-. -NR7C(O)R7, -OC O)OR7, -SC(O)OR7, -NR7C(0)OR7, -OCH2C(O)R7, -SCH3C(0)R7, -NR7CH=C(0)R7, -OCH2C(0)OR7, -SCH2C(0)OR7, -NR7CH:C(0)QR7, -OCH:C(O)NR,0Rii, - -NR7CH:C(0)NR;oRu, -OS(O)pR7! -SS(O)PR7,-S(O)POR7, -NR7S(O)PR7! -OS^pNR^Rn.-SSCOJpNR^Ru, -NR7S(O)PNR,CR,1) -OS(O)POR7) -SS(O)POR7, -NR7S(0)pOR7l -OC(S)R7) -SC(S)R7) -NR7C(S)R7, -OC(S)OR7) -SC(S)OR7, -NR7C(S)OR7, -OC(S)NR,0Rii, -S:(S)NR,0Rii, -NR7C(S)NR,0Rii, -OC(NRg)RT. -SC(NR«)R7, -NR7C(NRs)R7, -OC(NR8)OR7> -SC(NR8)OR7, -NR7C(NRs)OR7, -OC(NK8)NR|0Rn, -SC(NR8)KR,0Riu -NR7C(NRs)NR,0Rii, -OP(O)(OR7)2) or -SP(O)(OR7);!; R3 is -OH, -SH, -NR7H, -OR26, -SR26, -NHR26, -O(CH2)mOH, -0(CH2)mSH, -0(CH:)mNR7H, -S(CH2)mOH, -S(CH:)mSH, -S(CH2)mNR7H, -OC(O)NR,oRi!, -SC(O)NR10Rii, -NR7C(O)NR10Rn, -OC(O)R7) -SC(O)R7, -NR7C(O)R7, -OC(O)OR7, -SC(O)OR7> -NR7C(O)OR7, -OCH2C(O)R7) -SCH2C(O)R7, -XR7CH:C(O)R7> -OCH2C(O)OR7, -SCH2C(O)OR7, -NR7CH2C(0)OR7, -OCH2C(O)NR,0Ru, -SCH2C(O)NR,0Rn, -NR7CH2C(0)NR!0Ru, -OS(O)PR7, -SS(O)PR7) -S(O)POR7) -NR7S(O)PR7, -OSCO^NfRioRn.-SSpNRioRn, -NR7S(O)pNRioRii, -OS(O)POR7> -SS(O)POR-. -NR7S(0)POR7, -OC(S)R7, -SC(S)R7) -NR7C(S)R-. -OC(S)OR7, -SC(S)OR7j -NR7C(S)OR7, -OC(S)NR,0R|i, -SC(S)KR10Rn, -NR7C(S)NR|0Rii, -OC(NR«)R-. -SC(NR8)R7) -NR7C(NR«)R7, -OC(NR8)OR7, -SC^NR8)OR7) -NR7C(NR8)OR7, -OC(NR8)NR,oR:s -SC(NR8)NR10Ru, -NR7C(NRg)NR10Rn, -OP(O)(OR7)2, or -SP(0)(OR7)2; Rs is an optionally substituted heteroaryl or an optionally substituted 8 to 14 membered aryl: R7 and R$. for each occurrence, are, independently, -H, an optionally substituted alkyl. an optionally substituted alkenyl, an optionally substituted alkynyl. an optionally substituted cycioaikyl, an optionally substituted cycloalkenyl. an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; RIO and RI;, for each occurrence, are independently -H, an optionally substituted alkyl. an optionally substituted alkenyl, an optionally substituted alkynyl. an optionally substituted cycioaikyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted hetergralkyl; or R IO and RH, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl; R.26 is a lower alkyl; p. for each occurrence, is, independently, 1 or 2; and m, for each occurrence, is independently, 1, 2. 3, or 4. In one embodiment, ring A of the the compounds of formula (1) is not a substituted [l,2.3]triazo!e, and/or compounds represented by formula (I) do not include 3-(2.4-dfnydroxy-phenyl)-4-(7-naphthalen-l-yl)-5-mercapto-triazole. The present invention also provides compounds having the formula (II): (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clathrates. and prodrugs thereof. In formula (II). ring A, RI, and R; are defined as for formula (I); and R: is a substituted phenyl, wherein the phenyl group is substituted with. i) one substituent selected from nitro, cyano, a haloalkoxy, an optionally substituted alkenyl, an optionally substituted alkynyl. an optionally substituted cycloalkyl, an optionally substituted c>cloalkenyl, an optional!} substituted heterocyclyl. an optionalK substituted aryl, an optionally substituted heteroaryl. an optionalK substituted aralkyl, an optionally substituted heteraralkyl, hydroxyialkyl, alkoxyalkyl. guanadino, -NRioRu, -O-Rzo, -C(O -C(O)OR20, -OC(O)R7, -C(O)NR|0Rii, -NRgC(O)R-. -SR7, -S(0)PR-, -OS(O)PR7, -S(O)POR7, -NR8S(O)PR7, or -S(O)pNR,,;Rii, or (Figure Removed) ii) two to five substituents selected from the group consisting of an optionally substituted alkyi, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, hydroxyalkyl, alkoxyalkyl, -F, -Br, -I, cva- . nitro, guanadino, a haloalkyl, a heteroalkyl, -NRioRn, -OR?, -C(O)R7, -C(0)OR7, -OC(O)R7, -C(0)NR10Ru, -NR«C(O)R7, -SR7, -S(07, -OS(O)PR7) -S(0)POR7) -NR8S(0)pR7, or -S(O)pNR10Ru; and R20, for each occurrence, is independently an optionally substituted alkyi, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl. In one embodiment, compounds represented by formula (II) do not include 3-(2,4-dihydroxy-phenyl)-4-(7-naphthalen-l-yl)-5-mercapto-triazole, 3-(2,4- dihydroxyphenyl)-4-(2,5-dimethoxyphenyl)-5-mercapto-triazole, 3-(l-phenyl-5- amino-pyrazoM-ylM-(2,4-dichloropheny)-5-rnercapto-triazole, or 3-(2-hydroxyphenyl) 4-(2,4-dimethylphenyl)-5-mercapto-triazole. The present invention also provides compounds having the formula (III): (Figure Removed) and tautomers, pharmaceutically acceptable salts, soivates, clathrates, and prodrugs thereof. In formula (III), ring A, RI, and Rj are defined as for formula (I); and (Figure Removed) RIS is an optionally substituted cycloalkyl, and optionally substituted cycloalkenyl, or a substituted alkyl, wherein the alkyl group is substituted with one or more substitjuents independently selected from the group consisting of an optionally substituted ftlkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, halo, cyano, nitro, guanadino, a haloalkyl, -NR,0Ru, -OR7, -C(0)R7, -C(O)OR7, -OC(O;R7, rC(O)NR,0Ri,, -NR8C(O)R7, -SR7) -S(0)PR7, -OS(O)PR7, -S(O)POR7, -NR8S(O)PR7, or -S(O)pNR|0Rii, -S(0)POR7, .OP(0)(OR7)2, or -SP(O)(OR7)2; In one embodiment, compounds represented by formula (III) do not include compounds In which Rig is cyclohexyl. The Invention also provides compounds represented by formula (IV) or formula (V); (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodmgs thereof. In formulas (IV) and (V), RI and R} are defined as for formula (I); and XH isO, S, orNR7; Rii is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; R:;, for each occurrence, is independently -H or is selected from the group consisting of an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl, a haloalkyl, -C(0)R7, -C(O)OR-, -OC(O)R7, -C(O)NR,oRn, -NR8C(O)R7) -S(O)PR7( -S(0)POR7, or -S(O)pNRioRii;and RJS and Ri*. for each occurrence, are independently -H or are selected from the group consisting of an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl, halo, cyano, nitro, guanadino, a haloaikyl, a heteroalkyl, -NR,0Rn, -OR7, -C(O)R7, -C(O)OR7, -OC(0)R7, -C(O)NR,oRii, -NR«C(0)R7, -SR7, -S(O)PR7, -OS(O)pR7, -S(O)POR7, -NRgS(0)pR7,or-S(O)pNR,oRii- The present invention also provides compounds represented by formula (VI): (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein: X4i is O, S, or NR421 X42 is CR44 or N; Y.to is N or CR»3; Y.j] is N or CRij; Y42, for each occurrence, is independently N, C or Z is OH, SH, or NHR7; Pai is -H, -OH, -SH, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, halo, cyano, nitro, guanadino, a haloalkyl, a heteroalkyl, an alkoxy or cycloalkoxy, a haloalkoxy, -NRioRu, -OR7, -C(O)R7, -C(O)OR7,-C(S)R7,-C(O)SR7,-C(S)SR7, -C(S)OR7, -C(S)NR!0Ra, -C(NR«)OR7, -C(NR«)R7, -C(NR8)NR,0R,i, -C(NRg)SR7, -OC(O)R7, -OC(O)OR7, -OC(S)OR7) -OC(NRg)OR7) -SC(O)R7, -SC(0)OR7, -SC(NR8)OR7, -OC(S)R7, -SC(S)R7) -SC(S)OR7, -OC(O)NRi0Rn, -OC(S)NR,0Ru, -OCCMRg)NRioRn, -SC(O)NRioRn, -SC(NRg)NRioRu, -SC(S)NR,0RU, -OC(NRS)R7, -SC(NR«)R7, -C(O)NR10Rn, -NR«C(O)R7, -NR7C(S)R7, -NR7C(S)OR7, -NR7C(NRg)R7, -NR7C(O)OR7, -NR7C(KRg)OR7, -NR7C(O)NR,0Ru, -NR7C(S)NR,oRn, -NR7C(NRg)NRloRii, -SR7, -S(O)PR7, -OS(O)pR7,-OS(O)POR7, -OS(0)pNR,oRii,-S(0)pOR7, -NR8S(O)PR7, ,,, -NR7S(O)POR7, -S(O)pNR,oRn, -SS(O)pR7l -SS(O)POR7, i, -OP(0)(OR7)2, or -SP(O)(OR7)2; RJ: is -H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyi, an optionally substituted heteraralkyl, hydroxyalkyl, alkoxyalkyl, a haioalkyl. a heteroalkyl, -C(O)R7, -(CH2)mC(O)OR7) -C(O)OR7( -OC(O)R7, -C(0)NR10Rn, -S(0)PR7, -S(0)POR7, or -S(O)pNR,0Ri|i; R^3 and R44 are, independently, -H. -OH, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraraikyl, hydroxyalkyl, alkoxyalkyl, halo, cyano, nitro, guanadino, a haloalkyl, a heteroalkyl, -C(O)R7, -C(O)OR-, -OC(0)R7) -C(O)NR,0Rii, -NR8C(0)R7) -SR7, -S(O)FR:, -OS(O)PR7) S(O)POR7, -NRgS(O)pR7> -S(O)PNR,0R! i, or R43 and R44 taken together with the carbon atoms to which they are attached form an optionally substituted cycloalkenyl, an optionally substituted aryl, an optionally substituted heterocyclyl, or an optionally substituted heteroaryl; R4s is -H, -OH, -SH, -NR7H, -OR26) -SR26, -NHR26, -O(CH2)mOH, -0(CH2)mSH, -0(CH:)mNR7H, -S(CH2)mOH, -S(CH2)mSH, -S(CH2)mNR7H. -OC(O)NR,oRi,, -SC(O)NR10Ri!, -NR7C(O)NR10Rii, -OC(0)R7, -SC(O)R7, -NR7C(O)R7, -OC(O)OR7> -SC(0)OR7) -NR7C(O)OR7) -OCH2C(O)R7, -SCH2C(0)R7, -NR-CH2C(O)R7, -OCH2C(O)OR7) -SCH2C(O)OR7, -NR7CH:C(O)OR:, -OCH2C(0)NR|0Rn, -SCH:C(O)NR!0Rii, -NR7CH:C(0)NRiCRn) -OS(O)PR7, -SS(O)PR7, -NR7S(0)PR7, -OS(O)PNRIOR.;. -SS^pNR.oR,,, -MR7S(0)pNR,0Rn, -OS(O)POR7, -SS(0)rOR7, -NR7S(O)POR7, -OC(S)R7, -SC(S)R7> -NR7C(S)R7) -OC(S)OR7, -SC(S)OR7, -NR7C(S)OR7> -OC(S)KR,oRu, -SC(S)NR10Rn, -NR7C(S)NR,oR,i, -OC(NR8)R7, -SC(NR8)R-, -NR7C(NR8)R7, -OC(NRg)OR7) -SC(NR8)OR7, -NR7C(NR8)OR7, -OC(NR«)NRioRii. -SC(NR8)NR,oRii,or -NR7C(NR8)NR,0Rii; R46, for each occurrence, is independently selected from the group consisting of H, an optionalK substituted alkyl, an optionally substituted aikenyl, an optionally substituted alkynyl. an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted ar> 1. an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraraikyl, halo, cyano, nitro, guanadino, a haloalkyl, a heteroalkyi. -NRioRn, -OR-, -Ci,O)R7) -C(0)OR7, -OC(O)R7, -C(O)NR,0Rn, -NR8C(O)R-. •SR.7, -S(0)PR7) -OS(0)PR7, -S(0)POR7, -NR8S(O)PR7, or -S(O)pNR10Ru; R7, Rg, RIO, RI :, R26, p, and m are defined as above. The present invention also provides compounds represented by formula (VII): (Figure Removed) and tautomers, pharmaceutical ly acceptable salts, solvates, clathrates, and prodrugs, wherein: Z, is -OH or -SH; and X42, R4i, RJ:, R43, and RAS are defined as above. The present invention also provides compounds having the formula (VIE): (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein: X45 is CR54 or N; Z is-OH or-SH; Rs2 is selected from the group consisting of-H, methyl, ethyl, n-propyl, isopropyl, n-butyl. n-pentyl, n-hexyl, -(CH2)2OGH3, -CH2C(O)OH, and - C(0)N(CH3)2; (Figure Removed) R3 and R5» ire each, independently, -H. methyl, ethyl, or isopropyi; ci R;3 and Rj4; taken together with the carbon atoms to which they are attached form a phenyl, cyclohexenyl, or cyclooctenyl ring; R55 is selected from the group consisting of-H, -OH, --OCH-,, and - OCH:CH3; and Rs6 is selected from the group consisting of-H, methyl, ethyl, isopropyi, and cyclopropyl. The present invention also provides compounds having the formula (IX): (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein, K«, for each occurrence, is independently, O, S, NRt2 or QRh; Y43 is NR47, C(R46)2, C(IU)2-C(R46)2, C(O), C(S), C(R46)2C(O), or C(IU):C(S); ¥4), ¥42, Z, R4i, R-42, and R^ are defined as above. In one embodiment, in formula (DC), Rai is selected from the group consisting of-H, lower alkyl, lower alkoxy, lower cycloalkyl, and lower cycloalkoxy. , In another embodiment, in formula (IX), R4\ is selected from the group consisting of-H, methyl, ethyl, propyl, isopropyi, cyclopropyl, methoxy, ethoxy, propoxy, and cyclopropoxy. In another embodiment, in formula (IX), R-»2 is selected from the group consisting of-H, methyl, ethyl, n-propyl, isopropyi, cyclopropyl, n-butyl, 5ec-buty: erf-butyl, n-pentyl, n-hexyl, -C(O)OH, -(CH:).TlC(O)OH, -CH2OCH3, -CH:rM:OCH3) and -C(0)N(CH,)2. In another embodiment, in formula (IX), ¥41 is CR^. Preferably, R«5 is H. a lower alkoxy, or -OH. In another embodiment, in formula (IX), ¥42 is CH. In another embodiment, in formula (IX), ¥43 is CH2. In another embodiment, in formula (IX), ¥43 is NR«, wherein R« is H or a lower alky I. In another embodiment, in formula (IX), one of X44 is NR12 and the other is CH: or C(R*)2. Preferably, one of X44 is NR42 and the other is CH2 In another embodiment, in formula (VI), Z is -OH. In another embodiment, Z is -SH. In another embodiment, the compound is selected from the group consisting of: 3-(2.4-dihydroxy-5-isopropyl-phenyl)-4-(l>3-beii2odiaxol-5-yl)-5-mercaptc*-[ 1,2,4] triazole; 3-(2.4-dihydroxy-5-isopropyl-phenyl)-4-(indan-5-yl)-5-mercapto-[ 1,2.4] triazole; 4-Ethyl-6-[5-mercapto-4-(l-methyl-2,3-dihydro-lH-indol-5-yl)-4H-[l,2,4]triazoI-3- yl]-benzene-l,3-diol; 5-(3-(5-ethyI-2,4-dihydroxyphenyl)-5-mercapto-4H-l,2,4-triazol-4-yI)indolin-2- one; 5-(3-(5-ethyl-2,4-dihydroxyphenyl)-5-mercapto-4H-l,2,4-triazol-4-yl)-lHbenzo[ d]imidazo[-2(3H)-one; 5-(3-(5-ethyl-2,4-dihydroxyphenyI)-5-mercapto-4H-l,2,4-triazol-4-yl)-lmethyliindolin- 2-cne; 4-isoprop>;-6-(5-mercapto-4-(4-propyl-3,4-dihydro-2H-benzo[b][l,4]oxa2in-6-yl)- 4H-l,2,4-triazol-3-yl)benzene-l,3-diol; 6-i,3-(5-ethyl-2,4'-dihydroxyphenyI)-5-mercapto-4H-l,2,4-triazol-4-yl)-2Hbenzo[ b][ 1.4]oxazin-3(4H)-one; 6-(3-(5-ethyl-2,4-dihydroxyphenyl)-5-mercapto-4H-l,2.4-triazol-4-yl)-3- methylbenzo[d]th:azol-2(3H)-one; 6-(3-(5-ethyl-2,4-dihydroxyphenyl)-5-mercapto-4H-l,2,4-triazol-4- yl)benao[d]thiazol-2(3H)-onv'; and tautomers, pharmaceutically acceptable salts, solvates, clathrales, and prodrugs thereof. Compounds of formula (IX) inhibit the activity of Hsp90 and are particularly useful for treating or preventing proliferative disorders, such as cancer. In addition, compounds of formula (IX) are particularly useful in treating cancer when given in combination with other anti-cancer agent. The present invention also provides compounds having the formula (X): (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clatnrates, and prodrugs thereof, wherein: X4i, Y4i, Y.;:, Z, R:, R«, RIO, RU, R The compounds shown in Table I or compounds of any formula herein, or tautomers. pharmaceutically acceptable salts, solvates, clathrates, hydrates, polymorphs or prodrugs thereof, inhibit the activity of Hsp90 and, thereby facilitates the degradation of Hsp90 client proteins. Hsp90 is necessary for the survival of normal eukaryotic cells. However, Hsp90 is over expressed in many tumor types indicating that it may play a significant role in the survival of cancer cells and that cancer cells may be more sensitive to inhibition of Hsp90 than normal cells. Thus, the compounds shewn in Table I or compounds of any formula herein, or tautomers, pharmaceutically acceptable salts, solvates, clathrates, hydrates, polymorphs or prodrugs thereof, are useful Treating proliferative disorders such as cancer. Although chemotherapeutic agents initially cause tumor regression, most agents that are currently used to treat cancer target only one pathway to tumor progression. Therefore, in many instances, after treatment with one or more chemotherapeutic agents, a tumor develops muhidrug resistance and no longer responses positively to treatment. One of the advantages of inhibiting Hsp90 activity is that several of its client proteins, which are mostly protein kinases or transcription factors involved in signal transduction, have been shown to be involved in the progression of cancer. Thus, inhibition of Hsp90 provides a method of short circuiting several pathways for tumor progression simultaneously. Therefore, treatment of tumors with an Hsp90 inhibitor of the invention either alone, or in combination with other chemotherapeutic agents, is more likely to result in regression or elimination of the tumor, and less likely to result in the development of more aggressive multidrug resistant tumors than other currently available therapeis. BRIEF DESCRIPTION OF THE DRAWINGS The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings in which like reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention. Figure 1 is a graph showing the ATPase activity of Hsp90 when untreated, when treated with 40 mM of Geldanamycin, a known Hsp90 inhibitor as a positive control, and when treated with 40(iM or 4(iM of Compound 108 of the invention; Figure 2 is gel showing the amount of Her2, an Hsp90 client protein, in cells that are untreated, in cells that have been treated with O.S^M, 2uM, or 5\iM of 17AAG, a known Hsp90 inhibitor, and in cells that have been treated with 0.5(aM, 2^M, or 5jj.M of Compound 108 or Compound 49; Figure 3 is a graph showing an FACSCalibur flow cytometer analysis of the c-kit positive population of HEL92.1.7 cells treated with Hsp90 inhibitors of the invention or 17AAG (as a positive control). The results indicate that the Hsp90 inhibitors of the invention induce c-kit degradation at a lower concentration than 17AAQ, an Hsp90 inhibitor that is currently in phase II clinical trials. Figure 4 is a graph showing an FACSOiibur flow cytometer analysis of the c-kit posirive population of Kasumi-1 cells treated with Hsp90 inhibitors of the invention or 17AAG (as a positive control). The results indicate that the Hsp90 inhibitors of the invention induce c-kit degradation at a lower concentration than 17AAG, an Hsp90 inhibitor that is currently in phase II clinical trials Figure 5 is a Western blot analysis of the c-kit from Kasumi-1 cells' treated with Hsp90 inhibitors of the invention or 17AAG (as a positive control). Figure 6 is a Western blot analysis of the c-met from NCI-HI 193 cells treated with Hsp90 inhibitors of the invention or 17AAG (as a positive control). Figure 7 displays the results of a nude mouse xenograft study to determine the effect of Compound 49 on the in vivo growth rate of the human tumor cell line MDA-MB-435S. Tumor bearing animals (8 mice/group) were intraperitoneal (IP) injected 5 times per week for 3 weeks (hatched bar) and the average tumor volumes for each group (+/- SEM) were determined every 3-5 days. Treatment with a dose of 300 mg/kg body weight of Compound 49 decreased the growth rate of MDAMB- 435S cells in nude mice to a greater extent than did a dose of 100 mg/kg body . weight of the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17- AAG); Figure 8 demonstrates that treatment with Compound 49 did not cause toxicity in a nude mouse xenograft model using the human tumor cell line MDAMB- 435S (tumor growth data from the same study is presented in Figure 3). Tumor bearing animals (8 mice/group) were intraperitoneal (EP) injected 5 times per week for 3 weeks (hatched bar) and the average percent changes in body weights for each group relative to the start of dosing were determined every 1-3 days (error bars not shown for clarity; mean coefficient of variation = 18%). Treatment with a dose of 300 mg/kg body weight of Compound 49 was not toxic, as indicated by its lack of an effect on the body weights in animals treated with Compound 49 versus vehicle treated animals: Figure 9 displays the results of a nude mouse xenograft study to determine the effect of Compound 188 on the in vivo growth rate of RERF-LC-AIlVP human lung tymor cells. Tumor bearing animals (8 mice/group) were i.p. injected 5 times per week for a total of 15 doses (hatched bar) and the average tumor volumes for each group (error birs represent SEM) were determined every 3-4 days. Treatment with a dose of 200 mg/kg body weight of Compound 188 inhibited rumor growth, as did a dose of 75 mg"kg body weight of 17-AAG (both compounds were dosed at approximately their maximum to'erated doses in nude mice); and Figure 10 demonstrates that treatment with Compound 188 does not cause overt toxicity in a nude mouse xenograft model using RERF-LC-AI|VP human lung tumor cells (data derived from the same study presented in Figure 5). Tumor bearing animals (8 mice/group) were i.p. injected 5 times per week for a total of 15 doses ('hatched ban and the cumulative average percent changes in body weights for each group relative to the start of dosing were determined every' 2-3 days. Treatment with a dose of 200 mg/kg body weight of Compound 188 was not overtly toxic, as indicated by the minimal effects on the animal body weights in the test article-treated versus vehicle-treated groups. DETAILED DESCRIPTION OF THE INVENTION A description of preferred embodiments of the invention follows. The present invention provides compounds and uses of said compounds. The present invention encompasses the use of the compounds of the invention to inhibit Hsp90 activity and for the treatment of a proliferative disorder, such as cancer. In particular, the present invention encompasses the use of compounds of the invention to slow or stop the growth of cancerous cells or to reduce or eliminate cancerous cells in a mammal. In certain embodiments, the compounds of the invention can be used in combination with o±er chemotherapeutic agents and may help to prevent or reduce the development or" multidrug resistant cancerous cells in a mammal. In this embodiment, the compounds of the invention may allow a reduced efficacious amount of a second chemotherapeutic agent given to a mammal, because compounds of the invention should inhibit the development of multidrug resistant cancerous cells, A. Terminology Unless other-vise specified, the below terms used herein are defined as follows: As used herein, the term "alky!" means a saturated straight chain or branched non-cyclic hydrocarbon having from 1 to 10 carbon atoms. Representative saturated straight chain alkyis include methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, nheptyl, n-octyl, n-nonyl and n-decyl; while saturated branched alkyis include isopropyl, sec-butyl, isobutyl, /er/-butyl, isopentyl, 2-methyIbutyl, 3-methylbutyl, 2- methylpentyl, 3-methylpentyl, 4-methylpentyl, 2-methylhexyl, 3-methylhexyl, 4- methylhexyl, 5-methylhexyl, 2,3-dimethy!butyl, 2,3-dimethylpentyl, 2,4- dimethylpentyl, 2,3-dimethylhexyI, 2,4-dimethylhexyl, 2,5-dimethylhexyI, 2,2- dimethylpentyl, 2,2-dimethylhexyl, 3,3-dimtheylper.tyl, 3,3-dimethylhexyl, 4,4- dimethylhexyl, 2-ethylpentyl, 3-ethylpentyl, 2-ethylhexyl, 3-ethylhexyl, 4- ethylhexyl, 2-methyl-2-ethylpentyl, 2-methyl-3-ethylpentyl, 2-methyl-4-ethylpenryl, 2-methyl-2-ethylhexyl, 2-methyl-3-ethylhexyl, 2-methyl-4-ethylhexyI, 2,2- diethylpentyl, 3,3-diethylhexyl, 2,2-diethylhexyl. 3,3-diethylhexyl and the like. The term "(;C|-C6)alky 1" means a saturated straight chain or branched non-cyclic hydrocarbon having from 1 to 6 carbon atoms. Representative (C)-C6)alkyl groups are those shown above having from 1 to 6 carbon atoms. Alkyl groups included in compounds of this invention may be optionally substituted with one or more substituents. As used herein, the term "alkenyl" means a saturated straight chain or branched non-cyclic hydrocarbon having from 2 to 10 carbon atoms and having at least one carbon-carbon double bond. Representative straight chain and branched (C:-Cio)alkenyls include vinyl, ally), 1-butenyl. 2-butenyl, isobutylenyl, 1-pentenyl, 2-pentenyl, 3-methyl- 1-butenyl, 2-methyl-2-butenyl, 2,3-dimethyl-2-butenyl, 1- hexenyl, 2-hexenyl, 3-hexenyl, 1-heptenyl, 2-heptenyl, 3-heptenyl, 1-octenyl, 1- octenyl, 3-octenyl, 1-nonenyl, 2-nonenyl, 3-nonenyl, 1-decenyl, 2-decenyl, 3- decenyl and the like. Alkenyl groups may be optionally substituted with one or more substituents. As used herein, the term "alkynyl" means a saturated straight chain or branched non-cyclic hydrocarbon having from 2 to 10 carbon atoms and having at lease one carbon-carbon triple bond. Representative straight chain and branched alkynyls include acerylenyi, propynyl, i-butynyl. 2-butynyl, 1-pentynyl, 2-pentynyl, 3-methyl- 1-butynyl, 4-pentynyl, 1-hexynyl, 2-hexynyl, 5-hexynyl, 1-heptynyl, 2- heptynyl, 6-heptynyl, 1-octynyl, 2-octynyl, 7-octynyl. 1-nonynyl, 2-nonynyl, 8- nonynyl, 1-decynyl. 2-decynyl, 9-decynyl, and die like. Alkyny! groups may be optionally substituted with one or more substituents. As used herein, the term "cycloalkyl" means a saturated, mono- or polycyclic alkyl radical having from 3 to 20 carbon atoms. Representative cycloalkyls include cyclopropyl, 1 -methylcyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, -cyclodecyl, octahydro-pentalenyl, and the like. Cycloalkyl groups may be optionally substituted with one or more substituents. As used herein, the term "cycloalkenyl" means a mono- or poly- cyclic nonaromatic alkyl radical having at least one carbon-carbon double bond in the cyclic system and from 3 to 20 carbon atoms. Representative cycloalkenyls include cyclopentenyl, cyclopentadienyl, cyclohexenyl, cyclohexadienyl.cycloheptenyl, c>cloheptadienyl, cycloheptatrienyl, cyclooctenyl, cyclooctadienyl, cyclooctatrienyl, cyclooptatetraenyl, cychnonenyl, cyclononadienyl, cyclodecenyl, cyclodecadienyl, 1.2,3,4,5,8-hexahydronaphthalenyl and the like. Cycloalkenyl groups may be optionally substituted with one or more substituents. As used herein, the term "haloalkyl" means and alkyl group in which one or more (including all) the hydrogen radicals are replaced by a halo group, wherein each h&lo group is independently selected from -F, -Cl, -Br, and -I. The term "halomethyl" means a methyl in which one to three hydrogen radical(s) have been replaced by a halo group. Representative haloalkyl groups include trifluoromethyl, bromomethyl, 1,2-cichloroethyl, 4-iodobutyl, 2-fluoropentyl, and the like. As used herein, an "alkoxy" is an alkyl group which is attached to another moiety via an oxygen linker. As used herein, an "haloalkoxy" is an haloalkyl group which is attached to another moiety via an oxygen linker. As used herein, the term an "aromatic ring" or "aryl" means a hydrocarbon monocyclic or poh cyclic radical in which at least one ring is aromatic. Example's of suitable aryl groups include, but are not limited to, phenyl, tolyl, anthracenyl, f.uoremyl, indenyl, azulenyl, and naphthyl, as well as benzo-fused carbocyclic moieties such as 5.6.7,8-tetrahydronaphthyl. Aryl groups may be optionally substituted with one or more substituents. In one embodiment, the aryl group is a monocyc'.icjing, whsrein the ring comprises 6 carbon atoms, referred to herein as "(C6)a*yl." As used herein, the term "aralkyl" means an aryl group that is attached to another group by a (Q-CeJalkylene group. Representative aralkyl groups include benzyl, 2-phenyl-ethyl, naphth-S-y'-methyl and the like. Aralkyl groups may be optionally substituted with one or more 'substituents. As used herein, the term "alkylene" refers to an alkyl group that has two points of attachment. The term "(Ci-C6)alkylene" refers to an alkylene group that has froim one to six carbon atoms. Straight chain (Ci-C6)alkylene groups are preferred. Non-limiting examples of alkylene groups include methylene (-CH--), ethylene (-CH2CH:-). n-propylene (-CH2CH;CH2-), isopropylene (-CH2CH(CH3)-), and the like. Alkylene groups may be optionally substituted with one or more substituents. As used herein, the term "heterocyclyl" means a monocyclic (typically having 3- to 10-members) or a polycyclic (typically having 7- to 20-members) heterocyclic ring system which is either a saturated ring or a unsaturated nonaromatic ring. A 3- to 10-membered heterocycle can contain up to 5 heteroatoms; and a 7- to 20-membered heterocycle can contain up to 7 heteroatoms. Typically, a heterocycle has at least on carbon atom ring member. Each heteroatom is independently selected from nitrogen, which can be oxidized (e.g., N(O)) or quaternized; oxygen: and sulfur, including sulfoxide and sulfone. The heterocycle may be attached via any heteroatom or carbon atom. Representative heterocycles include morpholinyl. thiomorpholinyl, pyrrolidinonyl, pyrrolidinyl, piperidinyl. piperazinyl, hydantoinyl, valerolactamyl, oxiranyl. oxetanyl, tetrahydrofuranyl. tetrahydropyranyl. tetrahydropyrindinyl, tetrahydropyrimidinyl, tetrahydrothiopheny:, tetrahydrothiopyranyl. and the like. A heteroatom may be substituted with a protecting group known to those of ordinary skill in the art, for example, the hydrogen on a nitrogen may be substituted with a tert-butoxycarbonyl group. Furthermore, the heterocyclyl may be optionally substituted with one or more substituents. Only stable isomers of such substituted heterocyclic groups are contemplated in this definition. (Figure Removed) As used herein, the term "heteroaromatk", "heteroaryl" or like terms means a monocyclic or polycyclic heteroaromatic ring comprising carbon atom ring members and one or more heteroatom ring members. Each heteroatom is independently selected from nitrogen, which can be oxidized (e.g., N(O)) or quaterrtized; oxygen; and sulfur, including sulfoxide and sulfone. Representative h'eteroaryl groups include pyridyl, 1-oxo-pyridyl, furanyl, benzo[l,3]dioxolyl, benzo[l,4]dioxinyl, thienyl, pyrrolyl, oxazolyl, imidazolyl, thiazolyl, a isoxazolyl, quinolinyl, pyrazolyl, isothiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, a triazinyl, triazolyl, thiadiazolyl, isoquinolinyl, indazolyl, benzoxazolyl, benzofuryl, indolizinyi, imidazopyridyl, tetrazolyl, benzimidazolyl, benzothiazolyl, benzothiadiazolyl, benzoxadiazolyl, indolyl, tetrahydroindolyl, azaindolyl, imidazopyridyl, quinazolinyl, purinyl, pyrrolo[2,3]pyrimidinyl, pyrazolo[3,4]pyrimidinyl, imidazo[l,2-a]pyridyl, and benzothienyl. In one embodiment, the heteroaromatic ring is selected from 5-8 membered monocyclic heteroaryl rings. The point of attachment of a heteroaromatic or heteroaryl ring to another group may be at either a carbon atom or a heteroatom of the heteroaromatic or heteroaryl rings-. Heteroaryl groups may be optionally substituted with one or more sWbstituents. As used herein, the term "(C5)heteroaryl" means an aromatic heterocyclic ring of 5 members, wherein at least one carbon atom of the ring is replaced with a heteroalom such as. for example, oxygen, sulfur or nitrogen. Representative (Cs)heteroaryls include furanyl, thienyl, pyrrolyl, oxazolyl, imidazolyl, thiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, pyrazinyl, triazolyl, thiadiazolyl, and the like. As used herein, the term "(C6)neteroaryF! means an aromatic heterocyclic ring of 6 members, wherein at least one carbon atom of the ring is replaced with a heteroatom such as. for example, oxygen, nitrogen or sulfur. Representative (Co)heteroaryls include pyridyl, pyridazinyl, pyrazinyl, triazinyl, tetrazinyl and the like. As used herein, the term "heteroaralkyl" means a heteroaryl group that is attached to another group by a (Ci-CeJalkylene. Representative heteroaralkyls include 2-(pyridin-4-yl)-propyl, 2-(thien-3-yl)-ethyl, imidazol-4-yl-methyl and the like. Heteroaralky! groups may be optionally substituted with one or more substituents. As used herein, the 'erm "halogen" or "halo" means -F, -Cl, -Br or -I. Suitable substiuients for an alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, aralkyl, heteroaryl, and heteroaralkyl groups include any substituent which will form a stable compound of the invention. Examples of substiruents for an alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, aralkyl, heteroaryl, and heteroarylalkyl include an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted, heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl. a haloalkyl, -C(O)NR28R29, -C(S)NR28R29, -C(NR3B)NR2gR29, -NR30C(O)R3|, -NR30C(S)R3i, -NR30C(NR32)R3,, halo, -OR30, cyano, nitro, haloalkoxy, -C(O)R:}o, -C(S)R30, -CCN^^Rso, -NR28R29, -C(O)OR30, -C(S)OR30, -C(NR3:)ORjo, -OC(O)R30, -OC(S)R30, -OC(NR32)R30, -NR30C(O)NR2gR:9. -XR3oC(S)NfR2gR29, -NR30C(NR32)NR28R29, -OC(O)NR2SR29, -OC(S)NR2»R29, -OGNR32)NR28R29, -NR30C(O)OR31, -NR30C(S)OR3i, -NR3oC(NR32)OR3i. -StO)hR30, -OS(O)pR30,, -NR30S(O)PR30, -S(O)pNR:8R29, -OS(O),j,NR28R29, or -NrR3oS(O)pNR2gR29, wherein R28 and R29, for each occurrence are. independently, H. an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; or R2g and R;g taken together with the nitrogen to which they are attached is optionally substituted heterocyclyl or optionally substituted heteroaryl; R3o and RSI for each occurrence are, independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl; and Rj2, for each occurrence is, independently, H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, -C(O)R3o, -C(O)NR28R29, -S(0)pR3o, or -S(0)pNR28R29; p, for each occurrence, is independently, 1 or 2; and h is 0, 1 or 2. In addition, alkyl, cycloalkyl, alkylene, a heterocyclyl, and any saturated portion of a alken>I, cycloalkenyl, alkynyl, aralkyl, and heteroaralkyl groups, may also be substituted with =O, =S, =N-R32. When a heterocyclyl, heteroaryl, or heteroaralkyl group contains a nitrogen atom, it may be substituted or unsubstituted. When a nitrogen atom in the aromatic ring of a heteroaryi group has a substituent the nitrogen may be a quaternary nitrogen. As used herein, the terms "subject", "patient" and "mammal" are used interchangeably. The terms "subject" and "patient" refer to an animal (e.g., a.bird such as a chicken, quail or turkey, or a mammal), preferably a mammal including a non-primate (e.g., a cow, pig, horse, sheep, rabbit, guinea pig, rat, cat, dog, and mouse) and a primaie (e.g., a monkey, chimpanzee and a human), and more preferably a human. In one embodiment, the subject is a non-human animal such as a farm animal (e.g.. a horse, cow, pig or sheep), or a pet (e.g., a dog, cat, guinea pig or rabbit). In a preferred embodiment, the subject is a human. As used herein, the term "lower" refers to a group having up to four atoms. For example, a "lower alkyl" refers to an alkyl radical having from 1 to 4 carbon atoms, 'lower alkoxy" refers to "-O-(Ci-Gi)alkyl and a "lower alkenyl" or "lower alkynyl' refers to ar. alkenyl or alkynyl radical having from 2 to 4 carbon atoms, respectively. Unless indicated otherwise, the compounds of the invention containing reactive functional groups (such as (without limitation) carboxy, hydroxy, thiol, and amino moieties'* also include protected derivatives thereof, "Protected derivatives" are those compounds in which a reactive site or sites are blocked with one ore more protecting groups. Examples of suitable protecting groups for hydroxyl groups include benzyl, methoxymethyl, allyl, trimethylsilyl, tert-butyldimethylsilyl, acetate, an j the like. Examples of suitable amine protecting groups include benzylcixycarbonyl, tert-butoxycarbonyl, tert-butyl, benzyl and fluorenylmethyloxycarbonyl (Fmoc). Examples of suitable thiol protecting groups include benzyl, tertbutyl, acetyl, methoxymethyl and the like. Other suitable protecting groups are well known to those of ordinary skill in the art and include those found in T. W. Greene, Protecting Groups in Organic Synthesis, John Wiley & Sons, Inc. 1981. As used herein, the term 'compound(s) of this invention" and similar terms refers to a compound of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX). (X), or Table 1, or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, polymortph or prodrug thereof, and also include protected derivatives thereof. The compounds of the invention may contain one or more chiral centers and/or double bonds and. therefore, exist as stereoisomers, such as double-bond isomers (i.e., geometric isomers), enantiomers, or diastereomers. According to this invention, the chemical structures depicted herein, including the compounds of this invention, encompass all of the corresponding compounds' enantiomers, diastereomers and geometric isomers, that is, both the stereochemically pure form (e.g., geometrically pure, enantiomerically pure, or diastereomerically pure) and isomeric mixtures (e.g., enantiomeric, diastereomeric and geometric isomeric mixtures). In some cases, one enantiomer, diastereomer or geometric isomer will possess superior activity or an improved toxicity or kinetic profile compared to other isomers. In those cases, such enantiomers. diastereomers and geometric isomers of compounds of this invention are preferred. As used herein, the term "polymorph" means solid crystalline forms of a compound of the present invention or complex thereof. Different polymorphs of the same compound can exhibit different physical, chemical and/or spectroscopic properties. Different physical properties include, but are not limited to stability (e.g, to heat or light), compressibility and density (important in formulation and product manufacturing), and dissolution rates (which can affect bioavailability). Differences in stability can result from changes in chemical reactivity (e.g., differential oxidation, such that a dosage form discolors more rapidly when comprised of one polymorph than when comprised of another polymorph) or mechanical characteristics (e.g., tablets crumble on storage as a kinetically favored polymorph converts to thermodynamically more stabie poiymorph) or both (e.g., tablets of one polymorph are more susceptible to breakdown at high humidity). Different physical properties of polymorphs can affect their processing. For example, one polymorph might be more likely to form solvates or might be more difficult to filter or wash free of impurities than another due to, for example, the shape or size distribution of particles of it. As used herein, the term "hydrate" means a compound of the present invention or a salt thereof, that further includes a stoichiometric or nonstoichiometric amount of water bound by non-covalent intermolecular forces. As used herein, he term "ciathrate" means a compound of the present invention or a salt thereof in the form of a crystal lattice that contains spaces (e.g-. channels) that have a guest molecule (e.g., a solvent or water) trapped within. As used herein and unless otherwise indicated, the term "prodrug" means a derivative of a compound that can hydrolyze, oxidize, or otherwise react under biological conditions (in vitro or in vivo) to provide a compound of this invention. Prodrugs may become active upon such reaction under biological conditions, or ±ey may have activity in their unreacted forms. Examples of prodrugs contemplated in this invention include, but are not limited to, analogs or derivatives of compounds of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (DC), (X), or Table 1 that comprise biohydrolyzable moieties such as biohydrolyzable amides, biohydirolyzable esters, biohydrolyzable carbamates, biohydrolyzable carbonates, biohydirolyzable ureides, and biohydrolyzable phosphate analogues. Other exarr.ries of prodrugs include derivatives of compounds of formula (I), (II), (III), (IV), (V. (VI), (Vll), (VIII), (IX), (X), or Table 1 that comprise -NO, -NO2, -ONO, or -ONO: moieties. Prodrugs can typically be prepared using well-known methods, such as those described by 1 BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY (1995) 172-178, 949-982 (Manfred E. Wolff ed.. 5th ed). As used herein and unless otherwise indicated, the terms "biohydrolyzable amide", "biohydrolyzable ester", "biohydrolyzable carbamate". "biohydrolyzable carbonate", "biohydrolyzable ureide" and "biohydrolyzable phosphate analogue" mean an amide, ester, carbamate, carbonate, ureide, or phosphate analogue, respectively, that either: 1) does not destroy the biological activity of the compound and confers upon that compound advantageous properties in vivo, such as improved water solubility, improved circulating half-life in the blood (e.g., because of reduced metabolism of the prodrug), improved uptake, improved duration of action, or improved onset of action; or 2) is itself biologically inactive but is converted in vivo to a biologically active compound. Examples of biohydrolyzable amides include, but are not limited to. lower alkyl amides, a-amino acid amides, alkoxyacyl amides, and aikylaminoalkylcarbonyl amides. Examples of biohydrolyzable esters include, but are not limited to. lower alkyl esters, alkoxyacyloxy esters, alkyl acylamino alky! esters, and choline esters. Examples of biohydrolyzable carbamates include, but are not limited to. lower alkylamines, substituted ethylenediamines, aminoacids, hydroxyalkylamines. heterocyclic and heteroaromatic amines, and polyether amines. As used herein, "Hsp90" includes each member of the family of heat shock proteins having a mass of about 90-kiloDaltons. For example, in humans the highly conserved Hsp90 family includes cytosolic Hsp90ct and Hsp90(3 isoforms, as well as GRP94; which is found in the endoplasmic retrulum, and HSP75/TRAP1, which is found in the mitochondria! matrix. The term "c-kit" or "c-kit kinase" refers :o a membrane receptor protein tyrosine kinase which is preferably activated upon binding Stem Cell Factor (SCF'> to its ewacellular domain (Yarden et al., 1987; Qiu et al., 1988). The full length amino acid sequence of a c-kit kinase preferably is as set forth in Yarden, et al., \m,EMBOJ., //:5341-3351;andQiu,efa/.. 1988, EMBO J., 7:1003-1011, which are incorporated by reference herein in their entirety, including any drawings. Mutant versions of c-kit kinase are encompassed by the term "c-kit kinase" and include those that fail into two classes: (1) having a single amino acid substitution at codon 816 of the human c-kit kinase, or its equivalent position in other species (Ma et al., 1999, J. Invest Dermatol., 7/2:165-170). and (2) those which have mutations involving the putative juxtamembrane z-helix of the protein (Ma, etal., 1999, J. (Figure Removed) Biol. Chem., 2/4:13399-13402), Both of these publications are incorporated by reference herein in their entirety, including any drawings. As used herein, a "proliferative disorder' or a "hyperproliferative disorder," and other equivalent terms, means a disease or medical condition involving pathological growth of cells. Proliferative disorders include cancer, smooth muscle cell proliferation, systemic sclerosis, cirrhosis of the liver, adult respiratory distress syndrome, idiopathic cardiomyopathy, lupus erythematosus, retinopathy, e.g., diabetic retinopathy or other retinopathies, cardiac hyperplasia, reproductive system associated disorders such as benign prostatic hyperplasia and ovarian cysts, pulmonary fibrosis, endometriosis, fibromatosis, harmatomas, lymphangiomatosis, sarcoidosis, desmoid tumors, Smooth muscle cell proliferation includes hyperproliferation of cells in the vasculature, for example, intimal smooth muscle cell hyperplasia, restenosis and vascular occlusion, particularly stenosis following biologically- or mechanicallymediated vascular injury, e.g., vascular injury associated with angioplasty. Moreover, intimal smooth muscle cell hyperplasia can include hyperplasia in smooth muscle other than the vasculature, e.g., bile duct blockage, bronchial airways of the lung in; patients with asthma, in the kidneys of patients with renal interstitial fibrosis, and the like. Non-cancerous proliferative disorders also include hyperproliferation of cells in the skin such as psoriasis and its varied clinical forms, Reiter's syndrome, pityriasis rubra pilaris, and hyperproliferative variants of disorders of keratinization (e.g., actinic keratosis, senile keratosis), scleroderma, and the like. In a preferred embodiment, the proliferative disorder is cancer. Cancers that can be treated or prevented by the methods of the present invention include, but are not limited to human sarcomas and carcinomas, e.g., fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, fymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas. cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, bladder carcinoma, epithelial carcinoma, glioma. astrocytoma. medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, retinoblastoma; leukemias, e.g., acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, myeloraonocytic, monccytic and erythroleukemia); chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and polycytihemia vera, lymphoma (Hodgkin's disease and non-Hodgkin's disease), multiple myeloma. Waldenstrobm's macroglobulinemia, and heavy chain disease. Other examples of leukemias include acute and/or chronic leukemias, e.g.. lymphocytic leukemia (e.g., as exemplified by the p388 (murine) cell line), large granular lymphoc>tic leukemia, and lymphoblastic leukemia; T-cell leukemias, e.g., T-cell leukemia (e.g., as exemplified by the CEM, Jurkat, and HSB-2 (acute), YAC- 1 (murine) cell lines), T-lymphocytic leukemia, and T-Iymphoblastic leukemia; B cell leukemia (e.g., as exemplified by the SB (acute) cell line), and B-lymphoc\tic leukemia; mixed cell leukemias, e.g., B and T cell leukemia and B and T lymphocytic leukemia; myeloid leukemias, e.g., granulocytic leukemia, myelocytic leukemia (e.g.. as exemplified by the HL-60 (promyelocyte) cell line), and myelogenous leukemia (e.g., as exemplified by the K562(chronic)cell line); neutrophilic leukemia; eosinophilic leukemia; monocytic leukemia (e.g., as exemplified by the THP-1 (acute) cell line); myelomonocytic leukemia; Naegeli-rype myeloid leukemia: and nonlymphocytic leukemia. Other examples of leukemias are described in Chapter 60 of The Chemotherapy Sourcebook, Michael C. Perry Ed., Williams & Williams (1992) and Section 36 of Holland Frie Cancer Medicine 5th Ed., Bast et al. Eds.. B.C. Decker Inc. (2000). The entire teachings of the preceding references are incorporated herein by reference. In one embodiment, the disclosed method is believed to be particularly effective in treating subject with non-solid tumors such as multiple myeloma. In another embodiment, the disclosed method is believed to be particularly effective against T-leukemia (e.g., as exemplified by Jurkat and CEM cell lines); B-Ieukemia (e.g., as exemplified by the SB cell line); promyelocytes (e.g., as exemplified by the HL-60 cell line); uterine sarcoma (e.g., as exemplified by the MES-SA cell line); monocytic leukemia (e.g., as exemplified by the THP-1 (acute) cell line); and lymphoma (e.g., as exemplified by the U937 cell line). Some of the disclosed methods can be particularly effective at treating subjects whose cancer has become "multi-drug resistant". A cancer which initially responded to an anti-cancer drug becomes resistant to the anti-cancer drug when the anti-cancer drug is no longer effective in treating the subject with the cancer. For example, many tumors will initially respond to treatment with an anti-cancer drug by decreasing in size or even going into remission, only to develop resistance to the drug. Drug resistant rumors are characterized by a resumption of their growth and/or Reappearance after having seemingly gone into remission, despite the administration of increased dosages of the anti-cancer drug Cancers that have developed resistance to two or more anti-cancer drugs are said to be "multi-drug resistant". For example, it is common for cancers to become resistant to three or more anti-cancer agents, often five or more anti-cancer agents and at times ten or more anti-cancer agents. As used herein, the term "c-kit associated cancer" refers to a cancer which has aberrant expression and/or activation of c-kit. c-Kit associated cancers include leukemias, mast cell tumors, small cell lung cancer, testicular cancer, some cancers of the gastrointestinal tract and some central nervous system. In addition, c-kit has been implicated in playing a role in carcinogenesis of the female genital tract (Inoue, et ai, 1994, Cancer Res., 54(\ 1):3049-3053), sarcomas of neuroectodermal origin (Ricottii et a/., 1998. Blood, 97:2397-2405), and Schwann cell neoplasia associated with neurofibromatosis (Ryan, et a!., 1994,7. AVuro. Res., 37:415-432). As used herein, the term "pharmaceutically acceptable salt," is a salt formed from, for example, an acid and a basic group of one of the compounds of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX). (X), or Table 1. Illustrative salts include, but are not limited, to sulfate, citrate, acetate, oxalate, chloride, bromide, iodide, nitrate, bisulfate, phosphate, acid phosphate, isonicotinate. lactate, salicylate, acid citrate, tartrate, oleate, tannate, pantothenare. bitartrate, ascorbate, succinate, maleate, besylate, gentisinate, fbmarate, glncqnate, glucaronate, saccharate, formate, benzoate, glutamate. methanesulfonate, ethanesulfonate, benzenesulfonate,/;- toluene$ulfonate, and pamoate (i.e., l,l'-methylene-bis-(2-hydroxy-3-naphthoate)) salts. The term "pharmaceutically acceptable salt" also refers to a salt prepared from a compound of formula (I), (II), (III), (TV), (V), (VI), (VII), (VIII), (IX), (X), or Table 1 having an acidic functional group, such as a carboxylic acid functional group, and a pharmaceutically acceptable inorganic or organic base. Suitable bases include, but are not limited to, hydroxides of alkali metals such as sodium, potassium, and lithium; hydroxides of alkaline earth metal such as calcium and magnesium; hydroxides of other metals, such as aluminum and zinc; ammonia, and organic amines, such as unsubstituted or hydroxy-substituted mono-, di-, or trialkylamines; dicyclohexylamine; tributyl amine; pyridine; N-methyl,Nethylamine; diethylamine; triethylamine; mono-, bis-, or tris-(2-hydroxy-lower alkyi amines), such as mono-, bis-, ortris-(2-hydroxyethyl)amine, 2-hydroxy-tertbutylamine, or tris-|hydroxymethyl)methylamine, N, N,-di-lower alkyl-N-(hydroxy lower alkyl)-amines. such as N,N-dimethyl-N-(2-hydroxyethyl)arnine, or tri-(2- hydroxycthyl)amine: N-methyl-D-glucamine; and amino acids such as arginine, lysine, and the like. The term "pharmaceutically acceptable salt" also refers to a salt prepared from a compound of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII). (IX), (X), or Table 1 having a basic functional group, such as an amine functional group, and a pharmaceutically acceptable inorganic or organic acid.. Suitable acids include, but are not limited to, hydrogen sulfate, citric acid, acetic acid, oxalic acid, hydrochloric acid (HC1), hydrogen bromide (HBr), hydrogen iodide (HI), nitric acid, hydrogen bisulfide, phosphoric acid, lactic acid, salicylic acid, tartaric acid, bitartratjc acid, ascorbic acid, succinic acid, maleic acid, besylic acid, fumaric acid, gluconic acid, glucarc-nic acid, formic acid, benzoic acid, glutamic acid, methanesulfonic acic. ethanesulfonic acid, benzenesulfonic acid, and/>- toluenesulfonic acid. As used herein, the term "pharmaceutically acceptable solvate," is a solvate formed from the association of one or more pharmaceutically acceptable solvent molecules to one of the compounds of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or Table 1. The term solvate includes hydrates (e.g., hemihydrate, monohj'drate, dihydrate, trihydrate, tetrahydrate, and the like). A pharmaceutically acceptable carrier may contain inert ingredients which do not ^nduly inhibit the biological activity of the compounds. The pharmaiceutically acceptable carriers should be biocompatible, i.e., non-toxic, noninfiamifriatory, non-immunogenic and devoid of other undesired reactions upon the administration to a subject. Standard pharmaceutical formulation techniques can be employled, such as those described in Remington's Pharmaceutical Sciences, ibid Suitable pharmaceutical carriers for parenteral administration include, for example, sterile vlvater, physiological saline, bacteriostatic saline (saline containing about 0.9% mg/ml benzyl alcohol), phosphate-buffered saline. Hank's solution, Ringer's-lactate and the like. Methods for encapsulating compositions (such as in a coating of hard gelatin or cyclodextran) are known in the art (Baker, et ai, "Controlled Release of Biological Active Agents", John Wiley and Sons, 1986). As used herein, the term "effective amount" refers to an amount of a compound of this invention which is sufficient to reduce or ameliorate the severity, duration, progression, or onset of a proliferative disorder, prevent the advancement of a proiliferative disorder, cause the regression of a proliferative, prevent the recurrence, development, onset or progression of a symptom associated with a proliferfrtive disorder, or enhance or improve the prophylactic or therapeutic effect(sj) of another therapy. The precise amount of compound administered to a subject (will depend on the mode of administration, the type and severity of the disease or condition and on the characteristics of the subject, such as general health, age, sex, body weight and tolerance to drugs. It will also depend on the degree, severity and type of cell proliferation, and the mode of administration. The skilled artisan will be able to determine appropriate dosages depending on these and other factors. When co-administered with other agents, e.g., when co-administered with an anti-cancer agent, an "effective amount" of the second agent will depend on the type of drug used. Suitable dosages are known for approved agents and can be adjusted by the skilled artisan according to the condition of the subject, the type of condition(s) being treated and the amount of a compound of the invention being used, in cases where no amount is expressly noted, an effective amount should be assumed. Non-limiting examples of an effective amount of a compound of the invention are provided herein below. In a specific embodiment, the invention provides a method of preventing, treating, managing, or ameliorating a proliferate disorder or one or more symptoms thereof, said methods comprising administering to a subject in need thereof a dose of at least 150 ug/kg, preferably at least 250 ig/kg, it least 500 ug/kg, at least 1 mg/kg, at least 5 mg/kg, at least 10 mg/kg, at least 25 mg/kg, at least 50 mg/kg, at least 75 mg/kg, at least 100 mg/kg, at least 125 mg/kg, at least 150 mg/kg, or at least 200 mg/kg or more of one or more compounds of the invention once every day, preferably, once every 2 days, once every 3-days, once evfcry 4 days, once every 5 days, once every 6 days, once every 7 days, once every 8 days, once every 10 days, once every tvvo weeks, once every three weeks, or once a month. The dosages of a chemotherapeutic agents other than compounds of the invention, which have been or are currently being used to prevent, treat, manage, or ameliorate a proliferative disorder, or one or more symptoms thereof, can be used in the combination therapies of the invention. Preferably, dosages lower than those which have been or are currently being used to prevent, treat, manage, or ameliorate a prolifejrative disorder, or one or more symptoms thereof, are used in the combination therapies of the invention. The recommended dosages of agents currently used for the prevention, treatment, management, or amelioration of a proliferative disorder, or one or more symptoms thereof, can obtained from any reference in the art including, but not limited to, Hardman et ai, eds., 1996, Goodmaln & Oilman's The Pharmacological Basis Of Basis Of Therapeutics 9th Ed, Mc-Graw-Hill. New York; Physician's Desk Reference (PDR) 57th Ed., 2003, Medical Economics Co., Inc., Montvale, NJ, which are incorporated herein by reference in its entirety. As used herein, the terms "treat", "treatment" and "treating" refer to the reduction or amelioration of the progression, severity and/or duration of a proliferalive disorder, or the amelioration of one or more symptoms (preferably, one or more discernible symptoms) of a proliferative disorder resulting from the administration of one or more therapies (e.g., one or more therapeutic agents such as a compound of the invention). In specific embodiments, the terms 'Treat", "treatment" and "treating" refer to the amelioration of at least one measurable physical parameter of a proliferate disorder, such as growth of a tumor, not necessarily discernible by the patient. In other embodiments the terms "treat", "treatment" and "Heating" refer to the inhibition of the progression of a proliferative disorder, either physically by, e.g., stabilization of a discernible symptom, physiolpgically by, e.g., stabilization of a physical parameter, or both. In other embodiments the terms "treat", "treatment" and "treating" refer to the reduction or stabilization of tumor size or cancerous cell count. As used herein, the terms "prevent", "prevention" and "preventing" refer to the redaction in the risk of acquiring or developing a given proliferative disorder, or the redaction or inhibition of the recurrence or a proliferative disorder. In one embodiment, a compound crthe invention is administered as a preventative measure to a patient, preferably a human, having a genetic predisposition to any of the disorders described herein. As used herein, the terms "therapeutic agent" and "therapeutic agents" refer to any agent(s) which can be used in the treatment, management, or amelioration of a proliferative disorder or one or more symptoms thereof. In certain embodiments, the term "therapeutic agent" refers to a compound of the invention. In certain other embodiments, the term "therapeutic agent" refers does not refer to a compound of the invention. Preferably, a therapeutic agent is an agent which is known to be useful for, or has been or is currently being used for the treatment, management, prevention, or amelioration a proliferative disorder or one or more symptoms thereof. As used herein, the term "synergistic" refers to a combination of a compound of the invention and another therapy (e.g., a prophylactic or therapeutic agent), which is more effective than the additive effects of the therapies. A synergistic effect of a combination of therapies (e.g., a combination of prophylactic or therapeutic agents) permits the use of lower dosages of one or more of the therapies and/or less frequent administration of said therapies to a subject with a proiiferative disorder. The ability to utilize lower dosages of a therapy (e.g., a prophylactic or therapeutic agerit! and/or to administer said therapy less frequently reduces the tnxicity associated with the administration of said therapy to a subject without reducing the efficacy of said therapy in the prevention, management or treatment of a prolifbrative disorder. In addition, a synergistic effect can result in improved efficacy of agents in the prevention, nanagement or treatment of a proliferative disorder. Finally, a synergistic effect of a combination of therapies (e.g., a combirption of prophylactic or therapeutic agents) may avoid or reduce adverse or unwanted side effects associated with the use of either therapy alone. As used herein, the phrase "side effects" encompasses unwanted and adverse effects pf a therapy (e.g., a prophylactic or therapeutic agent). Side effects are always unwanted, but unwanted effects are not necessarily adverse. An adverse effect from a therapy (e.g., prophylactic or therapeutic agent) might be harmful or uncomfortable or risky. Side effects include, but are not limited to fever, chills, lethargy, gastrointestinal toxicities (including gastric and intestinal ulcerations and erosions), nausea, vomiting, neurotoxicities, nephrotoxicities, renal toxicities (including such conditions as papillary necrosis and chronic interstitial nephritis), hepatic toxicities (including elevated serum liver enzyme levels), myelotoxicities (including leukopenia, myelosuppression, thrombocytopenia and anemia), dry mouth, metallic taste, prolongation of gestation, weakness, somnolence, pain (including muscle pain, bone pain and headache), hair loss, asthenia, dizziness, extra-pyramidal s>mptoms, akathisia, cardiovascular disturbances and sexual dysfunction. As used herein, the term "in combination" refers to the use of more than one therapies (e.g., one or more prophylactic and/or therapeutic agents). The use of the term "in combination" does not restrict the order in which therapies (e.g., prophylactic and/or therapeutic agents) are administered to a subject with a prolifeflative disorder. A first therapy (e.g., a prophylactic or therapeutic agent such as a compound of the invention) can be administered prior to (e.g., 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks before), concomitantly with, or subsequent to (e.g.. 5 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours, 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 8 weeks, or 12 weeks after) the administration of a second therapy (e.g., a prophylactic or therapeutic agent such as an anti-cancer agent) to a subject with a proUferattve disorder, such as cancer. As used herein, the terms "therapies" and "therapy" can refer to any protoc©l(s)', method(s), and/or agent(s) that can be used in the prevention, treatment, management, or amelioration of a proliferative disorder or one or more symptoms thereof. A used herein, a "protocol" includes dosing schedules and dosing regimens. The protocols herein are methods of use and include prophylactic and therapeutic protocols. As used herein, the terms "manage," "managing," and "management" refer to the !j»eneficial effects that a subject derives from a therapy (e.g., a prophylactic or therapeutic agent), which does not result in a cure of the disease. In certain embodiments, a subject is administered one or more therapies (e.g., one or more prophylactic or therapeutic agents) to "manage" a disease so as to prevent the progression or worsening of the disease. As used herein, a composition that "substantially" comprises a compound means that the composition contains more than about 80% by weight, more preferaibly more than about 90% by weight, even more preferably more than about 95% by weight, and most preferably more than about 97% by weight of the compound. As used herein, a reaction that is "substantially complete" means that the reaction contains more than about 80% by weight of the desired product, more preferably more than about 90% by weight cf the desired product, even more preferaibly more than about 95% by weight of the desired product, and most preferably more than about 97% by weight of the desired product. As used herein, a racemic mixture means about 50% of one enantiomer and about 50% of is corresponding enantiomer relative to a chiral center in the molecule. The invention encompasses all enantiomericalh-pure, enantiomericaily-enriched, diastereomerically pure, diastereomerically enriched, and racemic mixtures of the compounds of the invention. Enantiomeric and diastereomeric mixtures can be resolved into their component enantiomers or diastereomers by well known methods, such as chiralphase gjas chromatography, chiral-phase high performance liquid chromatography, crystallizing the compound as a chiral salt complex, or crystallizing the compound in a chiral solvent, Enantiomers and diastereomers can also be obtained from diastereomerically- or enantiomerically-pure intermediates, reagents, and catalysts by welliknown asymmetric synthetic methods. The compounds of the invention are defined herein by their chemical strucrunes and/or chemical names. Where a compound is referred to by both a chemical structure and a chemical name, and the chemical structure and chemical name conflict, the chemical structure is determinative of the compound's identity. When administered to a patient, e.g., to a non-human animal for veterinary use or for improvement of livestock, or to a human for clinical use, the compounds of the invention are administered in isolated form or as the isolated form in a pharmaceutical composition. As used herein, "isolated" means that the compounds of the invention are separated from other components of either (a) a natural source, such as a plant or cell, preferably bacterial culture, or (b) a-synthetic organic chemical reaction mixture. Preferably, the compounds of the invention are purified via conventional techniques. As used herein, "purified" means that when isolated, the isolate contains at least 95%, preferably at least 98%, of a compound of the invention by weight of the isolate either as a mixture of stereoisomers or as a diastereomeric or enantiomeric pure isolate. As used herein, a composition that is "substantially free" of a compound means that the composition contains less than about 20% by weight, more preferably less than about 10° o by weight, even more preferably less than about 5% by weight, and most preferably less than about 3% by weight of the compound. Only those choices and combinations of substituents that result in a stable structure are contemplated. Such choices and combinations will be apparent to "those ot ordinary skill in the art and may be determined without undue experimentation. The invention can be understood more fully by reference to the following detailed description and illustrative examples, which are intended to exemplify nonlimiting embodiments of the invention. B. The Compounds of the Invention The present invention emcompasses compounds having Formulas (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), and those set forth in Table 1 and tautomirs, pharmacsutically acceptable salts, solvates, clathrates, hydrates, polymorphs and prodrugs thereof. In one aspect, the invention provides compounds of formiula (I) as set forth below: (Figure Removed) and tauitomers, pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof* wherein ring A, Rj, RS and Rs are defined as above. Compounds of formula (I) inhibit the activity of Hsp90 and are particularly useful for treating or preventing proliferative disorders, such as cancer. In addition, compounds of formula (I) are particularly useful in treating cancer when given in combination with other anti-cancer agent. In one embodiment, in the compounds of formula (I), R5 is an optionally substituted naphthyl. In another embodiment, in the compounds of formula (I), Rs is represented bv the following formula: wherein: R$. for each occurrence, is independently a substituent selected from the group consisting of an optionally substituted alkyl. an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, hydroxyalkyl, alkoxyalkyl, halo, cyano, litro guanadino, a haloalkyl, a heteroalkyl, -NRioRii, -OR?, -C(O)R7, -C(0)GJ17, -OC(0)R7, -QOJNRuRu, -NR8C(0)R7, -SR7, -S(0)PR7) -OS(0)pR7, -S(O)p0R7, -NR8S(0)PR7, or -S(O)pNRi0Rii, -S(O)POR7, -OP(O)(OR7)2, or -SP(0)(pR7):; Or two Rg groups taken together with the carbon atoms to which they are attached form a fused ring; and in is zero or an integer from 1 to 7, wherein R7, R«, RIO, RH, and p are defined.as above. In another embodiment, in the compounds represented by formula (I), Rf is represented by one of the following formulas: wherein R? is defined as above; q is zero or an integer from 1 to 7; and u is zero or an integer from 1 to 8. In another embodiment, in the compounds represented by formula (I), R.- is selected from the group consisting of: (Figure Removed) and wherein: X6, for each occurrence, is independently CH, CRg, N, N(0), hT(R|7), provided that at- least three Xe groups are independently selected from CH and CR9; X?, for each occurrence, is independently CH, CRg, N, N(O), N+(R|7>, provided that at least three X? groups are independently selected from CH and CR9; Xg, for each occurrence, is independently CH2, CERg, CR9R9, O, S, S(O)pr NR7, or NR,7; Xg, for each occurrence, is independently N or CH; Xio, for each occurrence, is independently CH, CRg, N, N(O), N*(Ri7), provided that at least one XIQ is selected from CH and CR9; R.17, for each occurrence, is independently -H, an alkyl, an aralkyl, -C(O)R?, -C(0)OR7, or -C(0)NRioRu; wherein R7, R9, RIO, RH and p are defined as above. In another embodiment, in the compounds represented by formula (I), Rs is an optionally substituted indolyl, an optionally substituted benzoimidazolyl, an optionally substituted indazolyl, an optionally substituted 3#-indazolyl, an optionally substituted indolizinyl, an optionally substituted quinolinyl, an optionally substituted isoquinolinyl, an optionally substituted benzoxazolyl, an optionally substituted benzo[1.3]dioxolyl, an optionally substituted benzofuryl, an optionally substituted benzothiazolyl, an optionally substituted benzo[d]isoxazolyl, an optionally substituted benzo[d]isothiazolyl, an optionally substituted thiazolo[4,5- cjpyridinyl, an optionally substituted thiazolo[5,4-c]pyridinyl, an optionally substituted thiazolo[4,5-b]pyridinyl, an optionally substituted thiazolo[5,4- b]pyridi!nyl, an optionally substituted oxazolo[4,5-c]pyridinyl, an optionally substituted oxazolo[5,4-c]pyridinyl, an optionally substituted oxazolo[4,5- b]pyridinyl, an optionally substituted oxazolo[5,4-b]pyridinyl,an optionally substituted imidazopyridinyl, an optionally substituted benzothiadiazolyl, benzoxadiazolyl, an optionally substituted benzotriazolyl, an optionally substituted tetrahydroindolyl, an optionally substituted azaindolyl, an optionally substituted quinazoiinyl. an optionally substituted purinyl, an optionally substituted imidazo[4,5-a]pyridinyl, an optionally substituted im;dazo[l,2-a]pyridinyl, an optionally substituted 3//-imida2o[4,5-b]pyridinyl, an optionally substituted \Himidazo[ 4,5-b]pyridinyl, an optionally substitutec l//-imidazo[4,5-c]pyridinyl, an optionally substituted 3//-imidazo[4,5-c]pyridinyl, an bptionally substituted pyridopyrdazinyl, and optionally substituted pyridopyrimidinyl, an optionally substituted pyrrolo[2,3]pyrimidyl, an optionally substituted pyrazolo[3,4]pyrimidyl an optionally substituted cyclopentaimidazolyl, an optionally substituted cyclopefitatriazolyl, an optionally substituted pyrrolopyrazolyl, an optionally substituted pyrroloimidazolyl, an optionally substituted pyrrolotriazolyl, or an optionally substituted benzo(b)thienyl. In another embodiment, in the compounds represented by formula (I), RS is an optionally substituted indolyl. Preferably, RS is an indolyl represented by the following structural formula: wherein: R33 is a halo, lower alkyl, a lower alkoxy, a lower haloalkyl, a lower haloalkoxy, and lower alkyl sulfanyl; RSA is H. a lower alkyl. or a lower alkylcarbonyl; and Ring B and Ring C are optionally substituted with one or more substituents. Ip another embodiment, in the compounds represented by formula (I), Rs is selected from the group consisting of: (Figure Removed) wherein: Xi i, for each occurrence, is independently CH, CR9, N, N(O), or N*(Ri7), provided that at least one X; i is N, N(O), or N*(Rn) and at least two Xu groups are independently selected from CH and CR$; Xu, for each occurrence, is independently CH, CR9, N, N(O), N^Rp), provided that at least one Xi: group is independently selected from CH and CR Xu, for each occurrence, is independently O, S, S(0)p. NR7, orNRn; wherein R7, Rg and Rn are defined as above. In another embodiment, in compounds represented by formula (I), 01 ?ny of the embodiments of formula (I) in which particular groups are disclosed, the compound is represented by the following structural formula: (Figure Removed) wherein R;, RS, and RS are defined as above; and R£, for each occurrence, is independently an optional!;, substituted alkyl. an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl. an optionally substituted heterocyclyl, an optionally substinated aryl, an optionally substituted heteroan'l, an optionally substituted aralkyl, an optionally substituted heteroaralkM. halo, cyano, nitro. guanadino, a haloalkyl, a heteroalkyl. alkcxy, haloalkoxy, -NR.oRn, -OR7, -C(O)R7, -C(0)OR7, -C(S)R7, -C(O)SR7, -C(S)SR7, -C(S)OR:. -C(S)NR,oRn, -C(NRg)OR7, -C(NR8)R7, -C(NRg)NR,0Rii, -C(NRg)SR7, -OC(O)R- -OC(O)OR7, -OC(S)OR7, -OC(NRg)OR7, -SC(O)R7, -SC(0)OR7, -SC(NR«)OR7, -OC(S)R7> -SC(S)R7, -SC(S)OR7, -OC(0)NR,0R;i, -OC(S)NR10R11, -OC(NRs)NR10Rn, -SC(O)NR10Rn, -SC(NR8)NR10Ri!, -SC(S)NR!0Ru, -OC(NR8)R7,-SC(NR«)R7) -C(O)NR,0Ru, -NRSC(O)R7,-NR7C(S)R7l -NR7C(S)OR7, -NR7C(NR8)R7, -NR7C(O)OR7, -NR7C(NR8)OR7, -NR7C(Q)NR10Rn, -NR7C(S)NR10Ru, -NR7C(KRS)NR10R|i, -SR7, -S(O)PR7) -OS(Op7,-OS(0)POR7, -OS(0)pNR,oRn,-S(0)pOR7, -NR»S(O)PR7, -NR7S(0)pNR10Rli, -NR7S(0)POR7, -S(O)pNR10R,i, -SS(O)PR7, -SS(0)POR7, -SS(O)pNRioR! i, -OP(0)(OR7)2, or -SP(O)(OR7):; and n is zero of an integer from 1 to 4, wherein R7) Rg. RIO, Ru, and p are defined as above. In another embodiment, in compounds represented by formula (I), or any of the embodiments of formula (I) in which particular groups are disclosed, the compound is represented by the following structural formula: (Figure Removed) wherein RI, R;, RS, and R$ are defined as above; and R25 is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl. an optionally substituted heteroaryl, an optionally substituted aralkyi. an optionally substituted heteroaralkyl, halo, cyano, nitro, guanadino, a haloalkyl, aheteroalkyl.alkoxy, haloalkoxy,-NRioRn, -OR7, -C(O)R7, -C(O)OR7, -C(S)R|, -C(O)SR7, -C(S)SR7, -C(S)OR7) -C(S)NR,0Rn, -C(NR8)OR7, -C(NRg)R^, -CfNfR^NRioRn, -C(NR»)SR7, -OC(O)R7, -OC(O)OR7, -OC(S)OR7, -OC(NR8)OR7, -SC(0)R7, -SC(O)OR7, -SC(NR8)OR7, -OC(S)R-, -SC(S)R7, -SC(S)OR7, -OCl'OINRioRii, -OC(S)NRloRii, -OC(NRg)NR,0Rn, -SC(O)NfR,0Rn, -SC(NR8)NR..oR,!, -SC(S)NR10Rn, -OC(NRg)R-. -SC(NR8)R7, -C(O)NR10Rn, -NRiC(O)R7,,-NR?C(S)R7, -NR7C(S)OR7, -NR7C(NRg)R7) -NR7C(O)OR7, -XR7C(NRg)OR7, -NR7C(O)NRloRii, -NR7C(S)NRIORii, -NR7C(NR»)NR,0Ri i, -SR7, *S(0)PR7, -OS(0)pR7)-OS(0)POR7, -OS(O)PNR10R1,, -S(O)POR7) -NRiS(O)pR7, -NR7S(O)pNR,oRii, -NR7S(O)POR7, -S(O)pNRioRii, -SS(0)PR7, -SS(0)pOR7, -SS(0)pNRioRM, -OP(O)(OR7)2, or -SP(O)(OR7)2; kis 1,2, 3, or 4; and ' r is zero or an integer from 1 to 3, wherein R7, Rg, RIO, RH, and p are defined as above. In another embodiment of the compound represented by the above formula, RI, R3 and R25 are each independently -OH, -SH, -NHR7, -OC(0)NR|0Ri i, -SC(OJNRioRu. -OC(O)R7. -SC(0)R7. -OC(O)OR7, -SC(O)OR7, -OS(0)PR7. -S(O)POR7) -SS(O)PR7, -OS(0)POR7, -SS(O)POR7, -OC(S)R7. -SC(S)R7. -OC(S)OR7. -SC(S)OR7, -OC(S)NR,0Rii, -SC(S)NRioRn. -OC(NRg)R7, -SC(NRg)R7, -OC(NIR8)OR7, -SC(HRg)OR7. -OP(O)(OR7)2 or -SP(O)(OR7)2. In another embodiment of the compound represented by the above formula, R! and Rs are each, independently, -OH, -SH, or -NHR7. In this case, R« can be an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkyn> 1. cyano, halo, nitro, an optionally substituted cycloallcyl, haloalkyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, -OR7, -SR7, -NRioRii, -OC(O)NR|0Rn, -SC(0|NRIORu, -NR7C(0)NR,0Rn, -OC(0)R7, -SC(O)R7) -NR7C(O)R7, -OC(Q)OR7, -SCiO)OR7, -NR7C(0)OR7, -OCH2C(O)R7, -SCH2C(O)R7, -NR7GH2C(0)R;, -OCH2C(O)OR7, -SCH2C(O)OR7, -NR7CH2C(O)OR7, CHjC(0)NRicRn, -SCH2C(O)NR10Rn, -NR7CH2C(O)NR,oRu, -OS(O)PR7, -SS(0|PR7( -NR-SiO)pR7, -OS(0)pNR10R,i,-SS(O)pNR,0Rii, -NR7S(0)pNR,oR:!, -OS(O)POR7, -SS(O)POR7) -NR7S(0)POR7, -OC(S)R7, -SC(S)R7, -NR7C(S)R-. -OC(S;)OR7, -SC;S)OR7, -NR7C(S)OR7, -OC(S)NR10Rn, -SC(S)NR10Rn, -NR7C(S)NRioRn, -OC(NRg)R7, -SC(NR8)R7, -NR7C(NRg)R7, -OC(NR8)OR7, -SC(MR8)OR7, -XR7C(NRg)OR7, -OC(NRg)NR,0Rii, -SC(NRg)NR,0Rit, -NR7G(NR8)NR ;RU, -C(O)R7) -C(O)OR7, -C(O)NR,0Rn, -C(O)SR7) -C(S)R7, -C(S)OR7, -C(S)NRIORii, -C(S)SR7, -C(NR8)OR7, -C(NR8)R7, -C(NR8)NR10R,,, -C(NRS)SR7, -S(0)FOR7, -S(0)pNR,oRii,or -S(O)PR7. In another embodiment of the above compound, R| is -SH or -OH; R} and R25 are -OH; R^ is a lower alkyl, C3-C6 cycloalkyl, lower alkoxy, a lower alkyl sulfanyU or -NRioRn; and Rg, for each occurrence, is independently selected from the group consisting of -OH, -SH,.halo, a lower haloalky!. cyano, a lower alkyl. a lower alkoxy, and a lower alkyl sulfanyl. In another embodiment, in compounds represented by formula (I), or any or" the embodiments of formula (I) in which particular groups are disclosed, RI and R} are each, independently, -OH, -SH, or -NHR7. In another embodiment, in compounds represented by formula (I), or any of the embodiments of formula (I) in which particular groups are disclosed, the compound is represented by the following structural formula: (Figure Removed) wherein RI, R^, RS, and R25 are defined as above; and RS is an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, cyano, halo, nitro. an optionally substituted cycloalkyl, haloalkyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralky!. an optionally substituted heteroaralkyl, -OR7, -SR7, -NRioRu, -OC(CWRioRii, -SC(0)NRioRn, -NR7C(0)NR,0Rn, -OC(0)R7, -SC(O)R7, -NR7G, -SCH:C(O)R7, -NR-CH2C(O)R7)-OCH2C(0)OR7, -SCH2C(0)OR7, -NR7CH:C(O)OR7, -OCH2C(0)NRioRn, -SCH:C(O)NR|0Rn, -NR7CH2C(0)KR,oRn, -OS(O)PR7) -SS(O)PR7, -NR7S(O)PR7, -OS(O)pNR10Rii, -SS(0)PNRloRn, -NR7S(0)pNRioRii, -OS(0)POR7, -SS(O)POR7, -NR7S(O)POR7, -OC(S)R7, -SC(S)R7, -NR7C(S)R7, -OC(S)OR7, -SC(S)OR7) -NTR7C(S)OR7, •OC(S)NR,oR:i, -SG.S)NRloR,i, -NR7C(S)NR,0Rii, -OC(NRS)R7, -SC(NRg)R7, -NR-C -NR7C(NR8)OR7, -OC(NR«)NRioRii, -SC(NRg)NR,0Rn, -NR7C(NRg)NrR,0Rn, -C(O)R7, -C(0)OR7, -C(0)NR;;,R,,, -C(0)SR7, -C(S)R7, -C(S)OR7) -C(S)NR,oRii, -C(S)SR7, -C(NR8)OR7, -C(NR8)R7, -C(NRg)NR,0Rii, -C(NRS)SR7, -S(O)POR7, -S(0)pNRioR;:, or -S(O)PR7, wherein R7, Rg, RIO, RH, and p are defined as above. In a prafered embodiment, RI is -SH or -OH; RS and R25 are -OH; R^ is a lower alkyl. lower alkoxy. a lower alkyl sulfanyl, or -NRioRnJ and Rg, for each occurrence, is independently selected from the group consisting of -OH, -SH, halo, a lower haloalkyl, cyano, a lower alkyl, a lower alkoxy, and a lower alkyl sulfanyl. In another embodiment, in compounds represented by formula (I), or any of the embodiments of formula (I) in which particular groups are disclosed, the compound is represented by one of the following structural formulas: (Figure Removed) wherein RI, R;,. Rs, R& and n are as defined above; and X3 and X4 are each, independently, N, N(O), N*(R|7), CH or CR*; and X5 is O. S, MR;-, CH-CH, CH=CR*. CR6=CH, CR6=CR6, CH=N, CR6=N, CH 0), CR^N(O). N=CH, N=CR6, N(O)=CH, N(O)=CR6, N+(R17)=CH, T(.R,7)=CRj. CH=N"i.Rn), CR6=NT(Ri7), or N=N: wherein Ri7 is defined as above. In another embodiment, in compounds represented by formula (I), or any of the embodiments of formula (I) in which particular groups are disclosed, the compound is selected from the group consisting of: , (Figure Removed) and wherein R( , R;, Rs, and R25 are defined as above. In another aspect, the invention provides compounds of formula (II) as set forth below: (Figure Removed) and tauiomers, pharmaceutically acceptable salts, solvates, clathrates. and prodrugs thereof wherein ring A, R| and R} are defined as above; and R; is a substituted phenyl, wherein the phenyl group is substituted with: i) one substituent selected from nitro, cyano, a haloalkoxy, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, hydroxylalkyl, alkoxyalkyl, guanadino, -KRloRii, -O-Rio. -C(O)R7, -C(0)OR20, -OC(0)R7, -C(0)NR,oR,i, -NR8C(O)R7, -SR7. -S(O)?R7, -OS(O)PR7, -S(O)POR7> -NR8S(O)PR7, or -S(O)PNR,0Rii, or ii) two to five substituents selected from the group consisting of an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkeny!, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl. an optionally substituted aralkyl, an optionally substituted heteraralkyl, hydroxyalkyl, alkoxyalkyl, -F, -Br, -I, cyano, nitro, guanadino, a haloalkyl, a heteroalkyl, -NRioRu, -OR?, -C(O)R?, -C(0)OR7, -OC(O)R7) -C(O)NR,oR;i, -NRsC(O)R7, -SR7, -S(O)PR7, -OS(O)PR7, -S(O)POR7, -NR8S(O)PR7, or -S(O)pNR!0R,,; R2o, for each occurrence, is independently an optionally substituted alky!, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraealkyl; p, for each occurrence, is, independently, 1 or 2. Compounds of formula (II) inhibit the activity of Hsp90 and are particularly useful ;tor treating er preventing proliferative disorders, such as cancer. In addition, compqunds of formula (II) are particularly useful in treating cancer when given in combination with other anti-cancer agent. In one embodiment, the compounds represented by formula (II) do not include 3-(2,4-dihdroxy-phenyl)-4-(7-naphthaIen-l-yl)-5-mercapto-triazole, 3-t2,4- dihydrbxyphenyl)-4-(2,5-dimethoxyphenyi)-5-mercapto-triazole, 3-(l-phenyl-5- aminotpyrazol-4-yh-4-(2,4-dichloropheny)-5-mercapto-triazole, and 3-(2-hydro.\yphenyl) 4-(2,4-dime:hylphenyI)-5-mercapto-triazole. In another embodiment, in compounds represented by formula (ID. or any of the embodiments of formula (II) in which particular groups are disclosed, the compdund is represented by the following structural formula: wherein R|. Rj, P-s, Re, and n are defined as above. In another embodiment, in compounds represented by formula (II), or any of the embodiments of formula (II) in which particular groups are disclosed, the compound is represented by the following structural formula: (Figure Removed) wherein RI, R:, Rs, Re, R:s and r are defined as above. In another embodiment, in compounds represented by formula (II), or any of the embodiments of formula (II) in which particular groups are disclosed, R] and R3 are each, independently, -OH, -SH, or -NHR?. In another embodiment, in compounds represented by formula (II), or any of the embodiments of formula (IT) in which particular groups are disclosed, the compound is represented by the following structural formula: (Figure Removed) wherein R;. R;, RS, R embodiment, R\ is -SH or -OH; R3 and R^5 are -OH; RI- is a lower alkyl, lower alkoxy, a lower alk} i sulfanyl, or -NR|0Ri i; and Ro, for each occurrence, is independent!) selected from the group consisting of -OH, -SH, halo, a lower haloalkyl, cyano, a iower alkyl, a lower alkoxy, and a lower alkyl sulfanyl. In another embodiment, in compounds represented by formula (II), or any of the embodiments of formula (II) in which particular groups are disclosed, the compound is represented by one of the following structural formulas: (Figure Removed) wherein RI, R;, R:, R$, Xs, X4, X$ and n are defined as above. In another embodiment, in compounds represented by formula (II), or any of the embodiments of formula (FI) in which particular groups are disclosed, the compound is selected from the group consisting of: (Figure Removed) and N N wherein RI, Ri, Rs, and R2j are defined as above. In another aspect, the invention provides compounds of formula (III) as set forth below: (Figure Removed) and tautomers. pharmaceutically acceptable salts, solvates, clathrates, and prodrugs. In formula (III), ring A. RI, and RS are defined as above; and Rig is an optionally substituted cycloalkyl, and optionally substituted cycloalkenyl, or a substituted alkyl, wherein the alkyl group is substituted with one or more substituents independently selected from the group consisting of an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, halo, cyano, nitro, guanadino, a haloalky!. -NRioRn, -OR7, -C(O)R7) -C(O)OR7> -OC(O)R7, -C(O)NRioRii, -NR;C(0)R7, -SR7, -S(O)pR7, -OS(O)PR7, -S(O)POR7, -NR8$(O)PR7, or -S(O)pNRioRi], wherein R~, Rg, RIO, RH, and p are defined as above. Compounds of formula (III) inhibit the activity of Hsp90 and are particularly useful for treating or preventing proliferate disorders, such as cancer. In addition, compounds of formula (III) are particularly useful in treating cancer when given in combination with other anti-cancer agent. In one embodiment, in formula (III) Rjg is not cyclohexyl. In another embodiment, in formula (III) RU is an optionally substituted cycloalky! or an optionally substituted cycloalkenyl. In another embodiment, in formula (III) RIS is a substituted alkyl. In another embodiment, in compounds represented by formula (III), or any of the embodiments of formula (III) in which particular groups are disclosed, the compound is represented by the ibllowing structural formula: (Figure Removed) wherein R<. r r6 ris and n are defined as above.> In another embodiment, in compounds represented by formula (III), or any or" the embodiments of formula (III) in which particular groups are disclosed, the compound is represented by the following structural formula: (Figure Removed) wherein R;, R;, R$, Rt s , R:S and r are defined as above. In another embodiment, in compounds represented by formula (III), or any of the embodiments of formula (III) in which particular groups are disclosed, Ri and Rj are each, independently, -OH, -SH, or -NHR7. In another embodiment, in compounds represented by formula (III), or any of the embodiments of formula (III) in which particular groups are disclosed, the compound is represented by the following structural formula: (Figure Removed) wherein R1, R2, R3, R4, and R5 are defined as above. In a preferred embodiment, RI is -SH or -OH; R3 and R25 lower alkoxy, a lower alkyl sulfanyl, or -NRioRn. In another embodiment, in compounds represented by formula (III), or an\ of the embodiments of formula (III) in which particular groups are disclosed, the compound is represented by one of the following structural formulas: (Figure Removed) 1 wherein RI, Rj, Rg, Rig, X3, X», Xs, and r. are defined as above. In another embodiment, in compounds represented by formula (III), or ar.y of the embodiments of formula (III) in which particular groups are disclosed, the compound is selected from the group consisting of: (Figure Removed) wherein R|. Rj, Rig, and R25 are defined as above. In another aspect, the invention provides compounds of formula (IV) or (V) as set forth below: (Figure Removed) and taiitomers, pharmaceutically acceptable salts, solvates, clathrates. and prodrugs thereof, hi formulas (IV) and (V), Rj and RI are as defined above: and X,4isO. S. orNR7; R2i is an optionally substituted alkyl, an optionally substituted alkenyl. an optionally substituted alkynyl, an optionally substituted cycloalkyl. an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl. an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyli, or an optionally substituted heteraralkyi; R:2, for each occurrence, is independently an -H or is selected from the group consisling of an optionally substituted alkyl, an optionally substituted alken>!, an optionally substituted alkynyl, an optionally substituted cycloalkyi. an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyi, a haloalkyl, -QOiR?, -C(O)OR7, -OC(0)R7, -C(0)NR,0Rii, -NR«C(O)R7, -S(O)PR7, -S(O)POR7> or -S(O)pNR|0Ri,;and R;3 and R;4, for each occurrence, are independently -H or are selected from the group consisting of an optionally substituted alkyl, an optionally substituted alkenyj, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl, halo, cyano, nitro, guanadino, ahaloalkyl, a heteroalkyl, -NRioRu, -OR?, -C(O)R7, -C(O)OR7, -OC(0)R7, -C(0)NR,0R,,, -NR8C(0)R7, -SR7, -S(0)PR7> -OS(0)PR7, -S(O)POR7) -NR8S|O)PR7. or -S(O)pNRioRu; wherein R7, Rg, RIO, Rn and p are defined as above. In one embodiment, in formulas (IV) and (V), R;i is an optionally substituted alkyi, .in optionally substituted cycloalkyl, an optionally substituted aryl or an optionally substituted heteroaryl. In another embodiment, in the formulas (IV) and (V), R: is -OH, -SH, or (Figure Removed) In another embodiment, in the formulas (FV) and (V), R;: is -H, an alkyl, an aralkyl, -C(O)R:, -C(0)OR7, or -C(O)NR,0Rii. In another embodiment, in the formulas (IV) and (V), X|4 is O. Compounds of formula (IV) or (V) inhibit the activity of Hsp90 and are paniculariy useful for treating or preventing proliferative disorders, such as cancer. In addition, compounds of formula (IV) or (V) are particularly useful in treating cancer when given in combination with other anti-cancer agent. In another aspect, the invention provides compounds represented by formula (VI): (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein: Xj) isO, S, orNRs:; Xj; is CR-u or N; Yo is N or C ¥4;, for each occurrence, is independently N, C or ZisOH, SH,orNHR7; R*] is -H. -OH, -SH. an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkeriyl, an optionally substituted heterocyclyl, an optionally substituted an 1, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, halo, cyano, nitro, guanadino. a haloalkyl, a heteroalkyl, an alkoxy or cycloalkoxy, a haloalkoxy. -NRioRi;, -OR-. -C(O)R7, -C(0)OR7)-C(S)R7,-C(O)SR7,-C(S)SR7) -C(S)OR7, -C(S)NR,oR,i, -C(NRg)OR7, -C(NR8)R7, -C(NRg)NR10Rn, -C(KR«)SR7) -OC(.O)R7l -OC(O)OR7, -OC(S)OR7, -OC(NR8)OR7, -SC(O)R7, -SC(O)OR7, -SC(NR8)OR7, -OC(S)R7. -SC(SiR7, -SC(S)OR7, -OC(O)NR10Rn. -OC(S)NR,0Rii, -OC(NiRs)NRi0R:i, -SC(O)NR|0Rn. -SC(NR8)NR10R,i, -SC(S)NRi0Rn, -OC(NRS)R7)-SC(NRg)R7, -C(0)NR,0Rn, -NRSC(O)R7,-NR7C(S)R7, -NR7C(S)OR7, -NR7C(NRg)R7, -NR7C(O)OR7, -NR7C(NR8)OR7, -NR7C(O)NRicRn, -NR7C(S)NRi0Riu -NR7C(NR5)NRioRii, -SR7, -S(O)PR-. .OS(Q)pR7,-OS.O)pOR7, -OS(0)pNR,oRii,-S(O)pOR7, -NRgS(0)pR7, -NR7S(O)pNRloR::, -NR7S(0)POR7, -S(O)pNR10Ri>, -SS(0)PR7) -SS(O)?OR7, -SS(0)pNR,0R|,, -OP(0)(OR7)2, or -SP(O)(OR7):; Rj2 is -H. an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloaikenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, hydroxyalk>'l, alkoxyalkyl, a haloalkyl, a heteroalkyl, -C(O)R7, -(CH2)mC(O)OR7! -C(0)OR7, -OC(0)R7, -C(0)NR,0Rii, -$ R43 and Rw are, independently, -H, -OH, an optionally substituted alkyl. an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substimted cycloalkyl, an optionally substituted cycloaikenyl, an optionally substituted heterocyciyl, an optionally substituted aryl. an optionally substituted heteraaryl, an optionally substituted aralkyl, an optionally substituted h^teraralkyl, hydroxyalkyl, alkoxyalkyl, halo, cyano, nitro, guanadino, a haloalkyl, a heteroalkyl, -C(0)R7, -C(0)QR7, -OC(O)R7, -C(0)NR10Rn, -NR8C(0)R7, -SR7, -S(O)PR7, -OS(0)PR7, -S(O)rOR7, -NR8S(O)PR7, -S(O)pNR|0Rii, or R43 and R« taken together with the carbon atoms to which they are attached form an optionally substituted cycloaikenyl, an optionally substituted aryl. an optionally substituted heterocyciyl, or an optionally substituted heteroaryl; Rjs is -H. -OH, -SH, -NR7H, -OR26, -SR:6. -NHR26, -CKCH^OH, -0(CH2)mSH, -OsCH2)mNR7H, -S(CH2)mOH, -S(CH2)mSH, -S(CH2)mNR7H, -OC(0)NR,0Ri,, -SC(0)NRioRn, -NR7C(O)NR|0R-.i, -OC(O)R7, -SC(O)R7, -NR7C(O)R7, -OdOOR?, -SC(0)OR7, -NR7C(O)OR7) -OCH2C(O)R-. -SCHjC(O)R7, -NR-CH2C(O)R7, -OCH2C(O)OR7, -SCH:C(O)OR7, -NR7CH2C(O)OR-. -OCH2C(O)NR|0Ri], -SCH2C(O)NR:0Rii, -NR7CH2C(O)NR :,Rn, -OS(O)PR7, -SS(O)PR7, -NR-S(OjpR7, -OS(O)?XR,oR;i. -SS(O)p:^R10Rn. -N^StOpNRioRn, -OS(O)POR7. -SS(0)POR7, -NR-S(O)POR7. -OC(S)R7, -SC(S.R7, -NR7C(S)R7, -OC(S)OR7) -SC(S)OR7, -NR7C(S)OR7, -OC(S)NR,0Rii, -SC(S)>fRioRii) -NR7C(S)NR|0Rn. -OC(NR8)R7, -SC(NRS)RT, -NR7C(NR8)R7, -OC(>fR8)OR7, -SC(NRg)OR7, -NR7C(NR8)OR7, -OC(NR8)NR,0R::- -SC^RgJNR^Rn, or -NR7C(NR8)NR,0Rn; Rj6, for each occurrence, is independently selected from the group consisting of H, an optionally substituted alkyl, an optionally substituted alkeny!, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloaikenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteraralkyl, halo, cyano, nitro, guanadino, a haloalkyl, a heteroalkyl, -NRioRn, -OR7, -C(0)R7) -C(0)OR7. -OC(O)R7, -C(O)NR10Ru, -NR8C(O)R7) -SR7, *S(O)pR7, -OS(O)PR7, -S(0)POR7, -NR8S(O)pR7) or -S(O)pNR,oR!,; R7, R«, RIO, RH, R26, p, and m are defined as above. In one embodiment, in formula (VI), Xu is NR42 and )C»2 is CRw- In another embodiment, in formula (VI), Xm is NR42 and X42 is N. In another embodiment, in formula (VI), R4i is selected from the group consisting of-H, lower alkyl, lower alkoxy, lower cycloalkyl, and lower cycloalkoxy. In another embodiment, in formula (VI), R^i is selected from the group consisting of-H, methyl, ethyl, propyl, isopropyl, cyclopropyl, methoxy. ethoxy, propoxiy, and cyclopropoxy. In another embodiment, in formula (VI), X^\ is NR42, and Rj2 is selected from ttye group consisting of-H, a lower alkyl, a lower cycloalkyl, -C(O)N(R;-);, and -C(O)OH, wherein R27 is -H or a lower alkyl. In another embodiment, in formula (VI), >LH is NR42, and R42 is selected from the group consisting of-H, methyl, ethyl, n-propyl, isopropyl, cyclopropyl. nbutyl, .tec-butyl, ten-butyl, n-pentyl, n-hexyl, -C(O)OH, -(CH;)mC(O)OH, -CH2OCH3, -CH:CH:OCH3, and -C(0)N(CH3)2. In one embodiment, ¥40 is CRj;,. Preferably, ¥40 is CR43 and R^s is H or a lower alkyl. In another embodiment, in formula (VI), R^3 and R^M are, independently, selected from the group consisting of-H. methyl, ethyl, propyl. isopropyl, cyclopropyl, methoxy, ethoxy, propoxy. and cyclopropoxy. In another embodiment, in formula (VI), >U2 is CR44; Y is CR43; and R^;. and R« together with the carbon atoms to w hich they are attached form a cycloalkenyl, an aryl, heterocyclyl, or heteroaryl ring. In one aspect of this embodiment, R43 and R_t4 together with the carbon atoms to which they are attached form a Cs-Cg cycloalkenyl or a C-Q aryl. In another embodiment, in formula (VI), Fits is selected from the group consisting of-H, -OH, -SH, -NH:. a lower alkoyy, a lower alkyl amino, and a lower dialkyl amino. In another embodiment, in formula (VI), R^s 'is selected from the group consisting of-H, -OH. methoxy and ethoxy. In another embodiment, in formula (VI), X^i is O. In another embodiment, the compound is selected from the group consisting of: 3-(2.4-dihydroxy-5-ethyl-phenyl)-4-(2-methyl-7-methoxy-benzor\iran-4-yl)- 5-merqapto-[l,2,4]tria2ole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(benzofuran-5-yl)-5-mercapto- [L2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(2-methyl-l,3-benzoxaz-5-yl)-5- mercapto-[l,2,4]triazole, and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodruigs thereof. In another embodiment, in formula (VI), Z is -OH. In another embodiment, the compound is selected from the group consisting of: 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l,3-dimethyl-indol-5-yl)-5-hydroxy- [1.2,4)triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(l,3-dimethyl-indol-5-yl)-5- hydrojcy-[ 1.2.4]triazole, 3-(2.4-dihydroxY-5-isopropyl-phenyl)-4-(l-methyl-indol-5-yi)-5-hydrox>- rJ,2.4Jtriazole, 3-(2.4-dihydroxy-5-isopropyl-phenyl)-4-(l-isopropyl-indol-4-yl)-5-hydroxy- [l,2,4]triazole, and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof. In another embodiment, Z is -SH. In another embodiment, the compound is selected from th^ group consisting of: 3-(2,4-dmydroxy-5-isopropyl-phenyl)-4-(l-methyl-indazol-5-yl)-5- mercapto-[l,2 4]triazole, 3-(2,4-dihydroxy-5-isopropyI-phenyl)-4-(l-methyl-indazol-6-yl)-5- mercapto-[l,2,4]tri'azole, and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodnjgs thereof. Compounds of formula (VI) inhibit the activity of Hsp90 and are particularly useful for treating or preventing proliferative disorders, such as cancer. In addition, compounds of formula (VI) are particularly useful in treating cancer when given in combination with other anti-cancer agent. In another aspect, the invention provides compounds represented by formula (VII): (Figure Removed) and tautomers. pharmaceutically acceptable salts, solvates, clathrates, and prodrligs thereof, wherein: Z, is -OH or -SH; 42, R4, R2, and R45 are defined as above. In one embodiment, in formula (VII), Z\ is -OH. In another embodiment, in formula (VII), Z\ is -SH. In another embodiment, in formula (VII). R4i is selected from the group consisting of-H. lower alkyl, lower alkoxy, lower cycloalkyl, and lower cycloalkoxy. In another embodiment, in formula (VII), RJI is selected from the group consisting of -H. methyl, ethyl, propyl, isopropyl, cyclopropyL methoxy, ethoxy, propoxy, and cyclopropexy. In another embodiment, in formula (VII), R42 is selected from the group consisting of lower alky!, lower cycloalkyl, -G O)N(R2?)2, or -C(O)OH, wherein R?7 is -H or a lower alkyl. In another embodiment, in formula (VLI), R,i is selected from the group consisting of-H, methyl, ethyl, n-propyl, isopropyl, cyc.lopropyl, n-butyi, .vec-buryl, ert-butyl, n-pentyl, n-hexyl, -C(O)OH, -(CH:^C(O)OH, -CH:OCH3, -CH2CH:OCH3. and -C(O)N(CHj)2. In another embodiment, RO is H or a lower alkyl. In another embodiment, in formula (VII), X»2 is CR44, and R43 and R^ are. independently, selected from the group consisting of-H, methyl, ethyl, propyl, isopropyl, cyclopropyl. methoxy, ethoxy, propoxy, and cyclopropoxy. In another embodiment, in formula (VLI), JCij is CILw, and R^ and &«, taken together with the carbon atoms to which they are attached, form a cycloalkenyl. aryl, heterocyclyl, or heteroaryl ring. Preferably, in this embodiment, R^ and R44, taken together with the carbon atoms to which they are attached, form a Cs-Cg cycloalkenyl or a Cs-C, aryl. In another embodiment, in formula (VTT), R^ is selected from the group consisting of -H. -OH, -SH, -NH:, a lower alkcxy, a lower alky! amino, and a lower dialkyl amino. In another embodiment, in formula (VH), R45 is selected from the group consisting of-H. -OH, methoxy, and ethoxy. In another embodiment, in formula (VU), X43 is CR44. In another embodiment, the compound is selected from the group consisting of: 3-(2,4-dihydrox\phenyl)-4-(l-ethyl-incol-4-yl)-5-mercapto-[l,2,4]triazole, 3-(2,4-dihydroxyphenyl)-4-(l-isopropyI-indol-4-yl)-5-mercapto- [l,2,4|triazole, 3-(2,4-dihydroxyphenyi)-4-(indol-4-yl)-5-mercapto-[l,2,4]triazole> 3-(2,4-dihydroxyphenyl)-4-(l-methoxyethyl-indol-4-yl)-5-mercapto- [l,2,4)triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-isopropyl-indo!-4-yl)-5-mercapto- [l,2,4Jtriazole, 3-(2,4-dihydroxyphenyl)-4-(l-dimethylcarbamoyl-indol-4-yl)-5-mercapto- [l,2,4]|riazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-( 1 -propyl-indol-4-yl)-5-mercapto- [l,2,4]triazole, 3-(2,4-dihydroxy-5-ethyI-phenyl)-4-(l,2,3-trimethyl-indol-5-yl)-5-mercapto- [l,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(2,3-dimethyl-iridol-5-yl)-5-mercapto- [l,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-acetyl-2,3-dimethyl-indol-5-yl)-5- mercayo-[ 1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-isopropy!-7-methoxy-indoI-4-yl)-5- mercapto-[ 1,2,4]tria2ole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-propyl-2,3-dimethyl-indol-5-yl)-5- mercapto-[ 1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(N-methyl-tetrahydrocarbozol-7-yl)-5- mercapto-[ 1,2r4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(N-methyl-cyclononan[a]indol-5-yl)-5- mercapto-[ 1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-n-butyl-indol-4-yl)-5-mercapto- [K2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyi)-4-(l-n-pentyl-indol-4-yl)-5-mercapto- [l,2,4]triazole, 3-(2,4-dthydroxy-5-ethyl-phenyl)-4-(l-n-hexyl-indol-4-yl)-5-mercapto- [l,2,4]friazole. 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(!-(!-mfthylcyclopropyl)-indol- 4-y l)-5-mercapto-[ 1,2.4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(l-isopropyl-7-methoxy-indol-4- yl)-5-mercapto-[ 1,2,4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(l,2,3-trimethyl-indol-5-yl)-5- . mercapto-[U2,4]triazoIe, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-isopropyl-7-methoxy-indo!-4-yi)-5- mercapto-[!,2,4]triazole disodium salt, 3-(2,4-dihydroxy-5-/erf-butyl-phenyl)-4-(l-isopropyl-7-methoxy-indol-4-\l)- 5-mercapto-[l,2.4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(l-propyl-7-methoxy-indol-4-yi)- 5-mefcapto-[1.2.4]tria2ole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-methyl-3-ethyl-indol-5-yl)-5- merc4pto-[l,2,4]triazole, 3-{2,4-dihydroxy-5-ethyI-phenyl)-4-(1.3-dimethyl-indol-5-yl)-5-mercapto- [l,2,4]triazole, _. 3-(2.4-dihydroxy-5-isopropyl-phenyl)-4-(l-isopropyl-7-methoxy-indol-4->l)- 5-me 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-methyI-3-isopropyl-indol-5-yl)-5- merc$pto-[ 1,2.41 triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-("NI-ethyl-carbozol-7-yl)-5-mercapto- [l,2,4]triazoie, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-isopropyl-7-hydroxy-indol-4-yl)-5- mercapto-[ 1,2.4]rriazole, 3-(2,4-dihydroxy-5-cthyl-phenyl)-4-(l-isopropyl-7-ethoxy-indol-4-yl)-5- mercapto-[l,2.4]tTiazoie, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l,2-dimethyl-indol-5-yl)-5-mercapio- [l,2,4]triazole. 3-(2,4-d:hydro\y-5-ethyl-phenyl)-4-(N-methyl-indol-5-yl)-5-mercapto- [l,2,4]triazole, 3-(2,4-d;hydroxy-5-isopropyl-phenyl)-4-(l,3-dimethyl-indol-5-yl)-5- mercapto-[l ,2,4jrriazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyI)-4-(l,3-dimethyl-indol-5-yl)-5- mercapto-[ 1,2,4]triazole, 3-(2,4-dihydroxy-5-cycIopropyl-phenyl)-4-(l-methyI-indol-5-yl)-5- mercapto-[ 1,2,4]triazole, 3-(2,4-dihydroxy-5-isopropyi-phenyl)-4-(lH-indol-5-yl)-5-mercapto- [1.2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l,2-dimethyI-indol-5-yl)-5-mercapto- [l,2,4]triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(I-ethyl-indol-5-yl)-5-mercapto- [1.2,4]triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(l-propyl-indol-5-yl)-5-mercapto- [1.2,4]|triazole, and tautomers, pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof. In another embodiment, in formula (VII), X42 is N. In another embodiment, the compound is selected from the group consisting of 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(l-ethyl-benzimidazol-4-yl)-5-mercapto- [!.2.4]triazole, 3-(2,4-dihydroxy-5-ethyi-phenyl)-4-( 1 -ethyl-benzimidazol -4-yl)-5- merca|)to-[l,2,4]nriazole HCL salt, 3-(2,4-dih\droxy-5-ethyl-phenyl)-4-(2-methyl-3-ethyl-benzimidazol-5-yl)-5- mercapto-[l,2,4]triazole, 3-(2,4-dih>droxy-5-ethyl-phenyl)-4-(l-ethyl-2-methyI-benzimidazol-5-yl)-5- mercaf)to-[ 1,2,4]triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(,l-methyl-2-trifluoromethylbenzimidazol- 5-yn-5-mercapto-[l,2,4]triazole, and tautomers. pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof. Compounds of formula (VII) inhibit the activity of Hsp90 and are particularly useful for treating or preventing proliferative disorders, such as cancer. In addition, compounds of formula (VII) are particularly useful in treating cancer when siven in combination with other anti-cancer asent. In another aspect, the invention provides compounds represented by formula (VII!); (Figure Removed) and tautomers, pharmaceutically acceptable salts, solvates, clathrates. and procrngs thereof, wherein: X4s is CR54 or N; Z, is-OH or-SH; RJ: is selected from the group consisting of-H, methyl, ethyl, n-propyl, isopropyl. n-butyl. n-pentvl, n-hexyl, -(CH2):OCH3, -CH2C(O)OH, and - C(0 R53 and R54 are each, independently, -H, methyl, ethyl, or isopropyl: or R,-;. and R.54 taken together with the carbon atoms to which they are attached form a phenyl, cyciohexenyl, or cyclooctenyl ring; R:-5 is selected from the group consisting of-H, -OH, -OCHs, and - OCHiCH3; and R?6 is selected from the group consisting of-H, methyl, ethyl, isopropyl, and cyc'.^propyl. In one embodiment, in formula (VIII). Z\ is -OH. In another embodiment, in formula (VIII), Z\ is -SH. In another embodiment, in formula (VIII), R_ In another embodiment, in formula (VIII), X4S is CR54. Preferably, R54 is H or a lower alkyl. In another embodiment, )C»5 is N. In another embodiment, the compound is 3-(2,4-dih\ droxy-5-isopropylphenyj)- 4-(N-methyI-indol-5-yl)-5-mercapto-[ 1,2,4]triazole. ' Compounds of formula (VIII) inhibit the activity of Hsp90 and are particularly useful for treating or preventing proliferative disorders, such as cancer. In addition, compounds of formula (VIII) are particularly useful in treating cancer when given in combination with other anti-cancer agent. In another aspect, the invention provides compounds represented by formula (IX): (Figure Removed) and :automers. pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, u herein, Xji. for eacn occurrence, is independently, 0, NR^ or Y4;, Y42, Z, RJI, R42, and R46 are defined as above. In one embodiment, in formula (IX), R^; is selected from the group consisting of -H, lower alkyl, lower alkoxy, lower cycloalkyl, and lower cvcloalkoxv, In another embodiment, in formula (IX\ RH is selected from the group consisting of -H, methyl, ethyl, propyl, isoprop;-!. cyclopropyl, methoxy, ethoxy, propoxy, and cyclopropoxy. In another embodiment, in formula (DO. Ra; is selected from the group consisting of-H, methyl, ethyl, n-propyl, isoprcpyl, cyclopropyl, n-butyl, sec-butyl, ;err-bi»tyi, n-pentyl. n-hexyl, -C(O)OH, -(CH:)-C(O)OH, -CH2OCH3, -CH.CHOCH;, and -C(0)N(CH3)2. In another embodiment, in formula (DO. Y4| is CR^. Preferably, RA$ is H, a lower alkoxy, or -OH. In another embodiment, in formula (DO. ¥43 is CH. In another embodiment, in formula (DO. ¥43 is CM:- In another embodiment, in formula (DO. ¥43 is NR42, wherein R^ is H or a lower alkyl. In another embodiment, in formula (DO. one of X44 is NR42 and the other is CH: or QR^. Preferably, one of X44 is NKj; and the other is CH2. In another embodiment, in formula (VD. Z is -OH. In another embodiment, Z is -SH. Compounds of formula (IX) inhibit the activity of Hsp90 and are particularlyuseful for treating or preventing proliferative disorders, such as cancer. In addition, compounds of formula (IX) are particularly useful in treating cancer when given in combination with other anti-cancer agent. In another aspect, the invention provide? compounds represented by formula (X): (Figure Removed) and tautomers, pharmaceutically acceptable saits, solvates, clathrates. and prodrugjs thereof, wherein: Xi, Y4i, Yc, Z, R7, Rg, RIO, RH, R-ti, R46, and p are defined as above. Jn one embodiment, in formula (X), R4i is selected from the group consisting of-H, lower alkyl. lower alkoxy, lower eyeloalkyl, and lower cycloalkoxy. In another embodiment, in formula (X), R4i is selected from the group consisting of-H, methyl, ethyl, propyl, isopropyl, cyclopropyl, methoxy, ethoxy, propoxy, and cyclopropoxy. In another embodiment, in formula (X), Xji is XR42. Preferably, R42 is selected; from the group consisting of-H, methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyi. .sec-butyl, /erf-butyl, n-pentyl, n-hexyl, -C(O)OH, -(CH;)mC(0)OH, -CH:OCH3, -CH2CH2OCH3) and -C O)N(CH3)2. More preferably, R_c is H or a lower alkyl. In another embodiment, in formula (X), Xti is O. In another embodiment, in formula (X), Xii is S. In another embodiment, in formula i X), Y4I is CR^s. Preferably, R,5 is H, a lower alkoxy, or -OH. In another embodiment, in formula i X), Y4: is CH. In another embodiment, in formula (,X), R^ is H or a lower alkyl. En one embodiment, the compound is 3-(2,4-tiihydroxy-5-isopropyi-phenyD- 4-(2-methyl-inda2ol-6-yl)-5-mercapto-[l,2,4]triazole. Compounds of formula (X) inhibit the activity ?f Hsp90 and are particularly useful for treating or preventing proliferative disorders, such as cancer. In addition. compounds of formula (X) are panicularly useful in treating cancer when given in combination with other anti-cancer agent. i) Exemplary Compounds of the Invention Exemplar) compounds of the invention are depicted ir Table 1 below, including tautomers. pharmaceutically acceptable salts, solvates, ci'athrates, hydrates, polymorphs or prodrugs thereof. Table 1 (Table Removed) Preferred compounds of the invention are those compounds that can form a tautomeric structure as shown below and as exemplified by the tautomeric structures shown in Table 1: (Figure Removed) Similarly, prodrugs, i.e. compounds which can be metabolized or hydrolyzed in vivo to a compound of the present invention are encompassed by the present description. For example, the following embodiments of a compound of the present invention can be produced in vivo in the following reaction: (Figure Removed) where Rjoo is R:, RS or Rig. One skilled in the art will understand that other hydrolyzable protecting groups can be employed with the compounds of the present invention to obtain prodregs encompassed by the present description. Witbaut wishing to be bound by any theory, it is believed that the compipunds of the invention preferentially bind to Hsp90 in the tautomeric form shown above, and thereby inhibit the activity of Hsp90. C. Methods for Making Compounds of the Invention Compounds of the invention can be obtained via standard, well-kncwn synthetic methodology, see e.g., March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992. In particular, compounds of the invention can bek>btained by heating a hydrazide (A) with an isocyanate (Xu = 0), isothiocyanate, (Xu = S) or carbodiimide (Xu = NR?) (B) in an alcohol to form intermediate (C). Intermediate (C) can be cyclized to form a triazole core (D) by heating it in an aqueous solution which includes about 2 molar equivalents of NaOH (see Sqheme I below). Starting materials useful for preparing compounds of the invention and intermediates therefore, are commercially available or can be prepared from commercially available materials using known synthetic methods and reagents. For example, a hydra/ide can be prepared by reacting an ester (such as 2,4- dihydr0xybenzoic acid methyl ester) or acid chloride with hydrazine. Isocyanates and isoithiocyanates (X-4 is O or S, respecii- ely) can be formed in a number of ways from compounds that have a primary amine group. For example, a primary amine can be reacted with phosgene or thiophosgene to form an isocyanate or an isothiocyanate, respectively. Alternatively, a cyanate or thiocyanate ion can be reacted with an alkyl halide to form an alkyl isocyanate or an alkyl isothiocyanate. In addition, a isothiocyanate can be prepared by reacting a diazonium salt with a thiocyanate ion. Carbodiimides (Xu is NR?) can be prepared by dehydration of ureas uging a dehydration agent such as tosyl chloride in pyridine, POCb, PC1. P:0s-pyridine. and PhsPB^-EtsN. Other methods of preparing isocyanates, thioisocyanates, and carbodiimides can be found in March, J. Advanced Organic Chemistry; Reactions Mechanisms, and Structure, 4th ed., 1992, the entire teachings of which are incorporated by reference. Compounds represented by formulas (IV) and (V) can be made in an analogyous fashion as compounds depicted in Scheme I. Reactive functional groups can be protected during one or more reaction step, then deprotected to restore the original functionality. Examples of suitable protecting groups for hydroxy! groups include benzyl, methoxymethyl, allyl, trimethylsilyl, tert-butyldimethylsilyl, acetate, and the like. Examples of suitable amine protecting groups include benzyloxycarbonyl, tert-butoxycarbonyl, tert-butyl, benzyl and fluorer.ylmethylqxy-carbonyl (Fmoc). Examples of suitable thiol protecting groups include benzyl, tert-butyl, acetyl, methoxymethyl and the like. Other suitable protecting groups are well known to those of ordinary skill in the art and include those found in T. W. Greene, Protecting Groups in Organic Synthesis, John Wiley & Sons, Inc. 1981. Scheme I: Synthesis of triazole compounds of the invention (Figure Removed) An alternative method of preparing the compounds of the invention is shown in Scheme II. In tnis method, an aryl, heteroaryl, cycloalkyl, or alkyl amine compound (i) is stirred at about room temperature with a thiocarbonyl (ii) which has two leaving groups. LI and La, such as imidazole-l-yl groups, to form compound (iii). Typically, the thiocarbonyl compound is present in a slight molar excess of about 1.05 eq. to ibout 1.3 eq. compared with compound (i). Compound (iii) is then combined with a h> drazide compound (iv) in a solvent and heated to about 50°C to about 100°C for about 0.5 to 5 hrs to form compound (v). Typically, compound (iii) and compound (i% can be present in about equal molar ratio or a slight excess of compound (iii), such as about 1.01 to about 1.1 molar eq. of compound (iii) compare to compound (iv). Compound (v) can then be cyclized to form a triazole compound of the invention (\:\ by suspending it in aqueous solution containing about 2 molar eq. of NaOH and heating the solution to about 75°C to about 110°C for about 0.5 hr to about 2 hrs. Typically, the NaOH solut:on containing compound (v) is degassed before heating by bubbling an inert gas, such as nitrogen or argon, through it. Scheme II: Alternative synthesis of triazole compounds of the invention (Figure Removed) In one embodiment, ring A of the compounds of the invention is a 2,4- dihydr0xyphenyl group. In this embodiment, it is sometimes desirable to prepare a prodrug by protecting the 4-hydroxy group with a moiety that can be hydrolyzed in vivo. Protection of the 4-hydroxy group is expected to improve the circulating halflife of Compound compounds of the invention. In addition, it is desirable that a group added to the 4-hydroxy group increase the water solubility of the compounds of the invention. In one embodiment, 4-methyl-piperizine-l-carbamoyl group is used to protect the 4-hydroxy group (see Scheme III). In this embodiment, a compound of the invention, such as compound (E), is treated with about one moiar equivalents of 4-methyl-piperizine-l-carbonyl chloride (F) in the presence of a base to form compound (G) in which the 4-hydroxy group is protected. Alternatively, the metcapto group can be protected first by reacting compound (E) with about one molar equivalent of acyl chloride in the presence of a base to form intermediate (H). Intermediate (H) can them be reacted with about one molar equivalent of 4-meth> 1- piperiziirie-l-carbonyS chloride (F) in the presence of a base, then the acetyl group can be removed by treatment with a mild acid to form compound (G). Schemje III: Preparation of prodmgs in which the 4-hydroxy group of compounds of the invention is protected with 4-methyl-piperizine-l-carbamoyl. (Figure Removed) Another prodrug of compounds of the the invention can be formed by addition of a phosphate group to the 4-hydroxy group (Scheme IV). In this embodiment, a compound of the invention, such as compound (E), is treated with about one molar equivalent of diisopropyl phosphoramidous acid di-t-butyl ester in the presence of tetrazole to yield compound (J). The phosphorous group is then oxidized with m-CPBA to form a phosphoric acid di-t-butyl ester group of compound K. The :-butyl groups are then hydrolyzed with trifluoroacetic acid (TFA) to > ield a phosphoric acid group or compound L. Scheme TV: Preparation of prodrugs in which the 4-hydroxy group of compounds of the invention is protected with a phosphate group. (Figure Removed) 1. (t-BuO)2PNi-Pr2, tstrazole 3.TFA D. Uses of Compounds of the Invention The present invention is directed to therapies which involve administering one or more compounds of the invention, or compositions comprising said compounds to a subject, preferably a human subject, to inhibit the activity of Hsp90 or to prevent, treat, manage, or ameliorate a proliferative disorder, such as cancer, or one or more symptoms thereof. In one embodiment, the present invention is directed to treating cancers in which aberrant expression and/or activation of c-kit has been implicated as contributing to neoplastic pathology by administering one or more compounds of the invention. In one aspect, the invention provides a method of inhibiting the activity of Hsp90 in a cell, comprising administering to the cell an effective amount of a compound represented by formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or any embodiment thereof, or a compound shown in Table 1. In one embodiment, the compound is administered to a cell in a subject, preferably a mammal, and more preferably a human. ' In another aspect, the invention provides a method of treating or preventing a proliferation disorder in a mammal, comprising administering to the mammal an effective amount of a compound represented by formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or any embodiment thereof, or a compound shown in Table 1. In one embodiment, the compound is administered to a human to treat or prevent a proliferative disorder. In another embodiment, the proliferation disorder is cancer. In another embodiment, the compound is administered with one or more additional therapeutic agents. In a preferred embodiment, the additional therapeutic agent is an anticancer agent. In another aspect, the invention provides a method for treating cancer in a . mammal, comprising administering to the mammal an effective amount of a compound represented by formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X),or any embodiment thereof, or a compound shown in Table 1. In one embodiment, the compound is administered to a human to treat or prevent cancer. In another embodiment, the compound is administered with one or more additional therapeutic agents. In a preferred embodiment, the one or more additional therapeutic agents are anticancer agents. In another aspect, the invention provides a method for treating a c-kit associated cancer in a mammal, comprising administering to the mammal an effective amount of a compound represented by formula (I), (II), (III), (IV), (V), (VI), (VII), (Mil), (IX), (X), or any embodiment thereof, or a compound shown in Table 1. In one embodiment, the compound is administered to a human to treat or prevent the c-kit associated cancer. In another embodiment, the compound is administered with one or more additional therapeutic agents. In a preferred embodiment, the one or more additional therapeutic agents are anticancer agents. 1. c-Kit Associated Cancers SCF binding to the c-kit protects hematopoietic stem and progenitor cells from apoptosis (Lee. et al., 1997, J. Immunol., 15S>:3211-3219), thereby contributing to colony formation and hematopoiesis. Expression of c-kit is frequently observed in acute myelocytic leukemia (AML) and sometimes observed in acute lymphoc>Tic leukemia (ALL) (for reviews, see Sperling, et a!., 1997, Haemal., 82:611-621; Escrihano, et u/.. 1998, Leuk. Lymph., 30:459-466). Although c-kit is expressed in the majority of AML cells, its expression does not appear to be prognostic of disease progression (Sperling, et a/, 1997, Haemal. 52:617-621). However, SCF protected AML cells from apoptosis induced by chemotherapeutic agents (Hassan, et a/., 1996, Ada. Hem., 9.5:257-262). Therefore, degradation of c-kit caused by the inhibition of Hsp90 by the compounds of the invembn will enhance the efficacy of these agents and may induce apoptosis of AML cells. The clonal growth of ceils from patients with myelodysplastic syndrome (Sawada, et al., 1996, Blood, 88:319-327) or chronic myelogenous leukemia (CML) (Sawai, et al., 1996, Exp. Hem., 2:116-122) was found to be significantly enhanced by SCF in combination with other cytokines. CML is characterized by expansion of Philadelphia chromosome positive cells of the marrow (Verfaillie, et al., 1998, Leuk., 12:136-138), which appears to primarily result from inhibition of apoptotic death (Jones, 1997, Curr. Opin. One., P:3-7). The product of the Philadelphia chromosome, p210.sup.BCR-ABL, has been reported to mediate inhibition of apoptosis (Bedi, et al., 1995, Blood, 86:\ 148-1158). Since p210.sup.BCR-ABL and the c-kit RTK both inhibit apoptosis and p62.sup.dok has been suggested as a substrate (Carpino, et al., 1997, Cell, 88:197-204), it is possible that clonal expansion mediated by th?se kirases occurs through a common signaling pathway. However, c-kit has also been reported to interact directly with p210.sup.BCR-ABL (Hallek, et al., 1996, Brit. JHaem., 94:5-16), which suggests that c-kit may have a more causative role in CML pathology. Therefore, degradation of c-kit caused by the inhibition of Hsp90 by the compounds of the invention will prove useful in the treatment of CML. Normal colorectal mucosa does not express c-kit (Bellone, et al., 1997, J. Cell Physiol., / 72:1 -11). However, c-kit is frequently expressed in colorectal carcinoma (Bellone. et al., 1997, J. Cell PhysioL, 172: 1-11), and autocrine loops of SCF and c-kit have been observed in several colon carcinoma cell lines (Toyota, et al., 1993, Turn. BioL. 14:295-302; Lahm, et al.. 1995, Cell Growth & Differ., 6:\ 111-1118; Bellone. etal., 1997,J. Cell Physiol., 772:1-11). Furthermore, disruption of the auiocrine loop by the use of neutralizing antibodies (Lahm, et a/., 1995, Cell Growth significantly inhibits cell proliferation (Lahm, et al, 1995, Cell Growth & Differ!.. 6:1111-1118; Bellone, etal., 1997,J. Cell Physiol., 172:1-] 1). SCF/c-kit autocrine loops have been observed in gastric carcinoma cell lines (Turner, et al., 1992. Blood, 50:374-381; Hassan, etal., 1998, Digest. Dis. Science, 43:8-14), and constitutive c-kit activation also appears to be important for gastrointestinal stromal tumors (GISTs). GISTs are the most common mesenchyinal tumor qf the digestive system. More than 90% of GISTs express c-kit,, which is consistent with the putative origin of these tumor cells from interstitial cells of Cajal (ICCs)(Hirota, et al, 1998, Ccience, 27P:577-580). The c-kit expressed in GISTs from several different patients was observed to have mutations in the intracellular juxtamembrane domain leading to constitutive activation (Hirota, et al., 1998, Science 279:577-580). Therefore, degradation of c-kit caused by the inhibition of Hsp90 by the compounds of the invention will be an efficacious means for the treatment of these cancers. Male germ cell tumors have been histologically categorized into seminomas, which retain germ cell characteristics, and nonseminomas which can display characteristics of embryonal differentiation. Both seminomas and nonseminomas are thought to initiate from a preinvasive stage designated carcinoma in situ (CIS) (Murty, et al., 1998, Sem. Oncol., 25:133-144). Both c-kit and SCF have been reported to be essential for normal gonadal development during embryogenesis (Loveland, et al., 1997, J. Endocrinol., 753:337-344). Loss of either the receptor or the ligand resulted in animals devoid of germ cells. In postnatal testes, c-kit has been found to be expressed in Leydig cells and spermatogonia, while SCF was expressed in Sertoli cells (Loveland, et al., 1997, J. Endocrinol., 153:337-344). Testicular tumors develop from Leydig cells with high frequency in transgenic mice expressing human papilloma virus 16 (HPV16) E6 and E7 oncogenes (Kondoh. et al.. 1991, J. Virol.. 65:3335-3339; Kondoh, etal., 1994, J. Urol., 752:2151-2154). These tumors express both c-kit and SCF, and an autocrine loop may contribute to the turmorigenesis (Kondoh, et al., 1995, Oncogene, 70:341-347) associated with cellular loss of functional p53 and the retinoblastoma gene product by association with E6 and E7 (Dyson, et al., 1989, Science, 243:934-937; Werness, et al., 1990, Science, 248:76-79: Scheffher, et al., 1990, Cell, 63:1129-1136). Defective signaling mutants of SCF (Kondoh, etal, 1995, Oncogene, 70:341-347) ore-kit (Li, et al.. 1996, Cane. Res., 5(5:4343-4346) inhibited formation of testicular tumors in mice expressing FfPV 16 E6 and E7. Since c-kit kinase activation is pivotal to tumoriigenesis in these animals, the compounds of the invention which inhibit Hsp90 and thereby cause the degradation of c-kit will be useful for preventing or treating testicular tumors associated with human papilloma virus. Expression of c-kit on germ cell tumors shows that the receptor is expressed by the majority of carcinomas in situ and seminomas, but c-kit is expressed in only a minority of nonseminomas (Strohmeyer, et al., 1991, Cane. Res., 57:1811-1816; Rajpertfde Meyts, et al., 1994, Int. J. Androl., 77:85-92; Izquierdo, et al., 1995, J. Pathol, 777:253-258; Strohmeyer, etal, 1995, J. Urol., 153:511-515; Bokenmeyer, et al., 1996, J. Cance. Res., Clin. Oncol, 722:301-306; Sandlow, et al., 1996, J. Androl. 77:403-408). Tnerefore, degradation of c-kit caused by the inhibition of Hsp90 by the compounds of the invention will be an efficacious means for the treatment of these cancers. SCF and c-kit are expressed throughout the central nervous system of developing rodents, and the pattern of expression suggests a role in growth, migration and differentiation of neuroectodermal cells. Expression of SCF and c-kit have also been reported in the adult brain (Hamel, et al., 1997, J. Neuro-Onc., 15:327-333). Expression of c-kit has also been observed in normal human brain tissue (Tada, et al. 1994, J. Neuro., 50:1063-1073). Glioblastoma and astrocytoma, which define the majority of intracrania! tumors, arise from neoplastic transformation of astrocytes (Levin, et al., 1997, Principles & Practice of Oncology, 2022-2082). Expression of c-kit has been observed in glioblastoma cell lines and tissues (Berdel, et al., 1992, Cane. Res., 52:3498-3502; Tada, et al., 1994, J. Neuro., 50:1063-1073; Stamilia, etal, 1995, Act. Neuropath., SP:158-165). The association of c-kit with astrocytoma pathology is less clear. Reports of expression of c-kit in normal astrocytes have been made (Natali, et al., 1992, Int. J. Cane., 12:197-201). (Tada, etal. (994, J. Neuro., 50:1063-1073), while others report it is not expressed (Kristt, et al., 1993, Neuro., 33:106-115). In the former case, high levels of c-ki: expression in high grade tumors were observed (Kristt, et al., 1993, Neuro., 53:106-115), whereas in the laker case researchers were unable to detect any expression in astrocytomas. In addition, contradictory reports of c-kit and SCF expression in neuroblastomas also exist. One study found that neuroblastoma cell lintis often express SCF, but rarely express c-kit. In primary tumors, c-kit was detected in about 8% of neuroblastomas, while SCF was found in 18% of tumors (Beck,, et al., 1995. Blood, 5(5:3132-3138). In contrast, other studies (Cohen, et ;?/.., 1994, Blood, 54:3465-3472) have reported that all 14 neuroblastoma cell lines examimed contained c-kit/SCF autocrine loops, and expression of both the receptor and ligand were observed in 45% of tumor samples examined. In two cell lines. anti-c*k5t antibodies inhibited cell proliferation, suggesting that the SCF/c-kit autocrine loop contributed to growth (Cohen, et al., 1994, Blood, 54:3465-3472). Therefore, degradation of c-kit caused by the inhibition of Hsp90 by the compounds of the invention vv ill be an efficacious means for treating some cancers of the central nervows system. 2. Combination Therapies and Treatment of Refractory Cancers The invention also provides methods of preventing, treating, managing, or ameliorating a proiiferative disorder, such as cancer, or one or more symptoms thereof, r-iid methods comprising administering to a subject in need thereof one or more compounds of the invention and one or more other therapies (e.g., one or more prophylactic or therapeutic agents that are currently being used, have been used, are known to be useful or in development for use in the prevention, treatment or amelioration of a proiiferative disorder, such as cancer, or one or more symptoms associated with said proiiferative disorder). The proph> lactic or therapeutic agents of the combination therapies of the invention can be administered sequentially or concurrently. In a specific embodiment, the combination therapies of the invention comprise one or more compounds and at least one other therapy (e.g., another prophylactic or therapeutic agent) which has the same mechanism of action as said compounds. In another specific embodiment, the combination therapies of the invention comprise one or more tjompounds of the invention and at least one other therapy (e.g., another prophylactic or therapeutic agent) which has a different mechanism of action than said compounds. In certain embodiments, the combination therapies of the present invention improve the prophylactic or therapeutic effect of one or more compounds of the invention b> functioning together with the compounds to have an additive or synergistic effect. In certain embodiments, the combination therapies of the present invention reduce trie side effects associated with the therapies (e.g., prophylactic or therapeutic agents). In certain embodiments, the combination therapies of the present invention reduce the effective dosage of one or more of the therapies. The prophylactic or therapeutic agents of the combination therapies can be administered to a subject, preferably a human subject, in the same pharmaceutical composition. In alternative embodiments, the prophylactic or therape itic agents of the combination therapies can be administered concurrently to a subject in separate pharmaceutical compositions. The prophylactic or therapeutic agents may be administered to a subject by the same or different routes of administration. In a specific embodiment, a pharmaceutical composition comprising one or more compounds of the invention is administered to a subject, preferably a human, to prevent, treat, manage, or ameliorate a proliferative disorder, such as cancer, or one or more symptom thereof. In accordance with the invention, pharmaceutical compositions of the invention may also comprise one or more other agents (e.g., prophylactic or therapeutic agents which are currently being used, have been used, or are known to be useful in the prevention, treatment or amelioration of a proliferative disorder or a symptom thereof)- The invention provides methods for preventing, managing, treating or ameliorating a proliferative disorder, such as cancer, or one or more symptoms thereof in a subject refractory (either completely or partially), to existing agent therapies for such a proliferative disorder, said methods comprising administering to said subject a dose of an effective amount of one or more compounds of the invention and a dose of an effective amount of one or more therapies (e.g., one or more prophylactic or therapeutic agents useful for the prevention, treatment, management, or amelioration of a proliferative disorder or a symptom thereof). The invention also provides methods for preventing, treating, managing, or ameliorating a proliferative disorder or a symptom thereof by administering one or more compounds of the invention in combination with any other therapy(ies) to patients who have proven refractory to other therapies but are no longeron these therapies. The compounds of the invention and/or other therapies can be administered to a subject by any route known to one of skill in the art. Examples of routes of administration include, but are not limited to, parenteral, e.g., intravenous, intraderrnal, subcutaneous, oral (?.g., inhalation), intranasal, transdermal (topical), transmucosal, and rectal administration. 3. Agents Useful In Combination With the Compounds of the Invention Without wishing to be bound by theory, it is believed that the compounds of the invention can be particularly effective at treating subjects whose cancer has become multi-drug resistant. Although chemotherapeutic agents initially cause tumor regression, most agents that are currently used to treat cancer target only one pathway to tumor progression. Therefore, in many instances, after treatment with one or more chemotherapeutic agents, a tumor develops multidrug resistance and no longer response positively to treatment. One of the advantages of inhibiting Hsp90 activity is that several of its client proteins, which are mostly protein kinases or transcription factors involved in signal transduction, have been shown to be involved in the progression of cancer. Thus, inhibition of Hsp90 provides a method of short circuiting several pathways for tumor progression simultaneously. Therefore, it is believed that treatment of cancer with an Hsp90 inhibitor of the invention either alone, or in combination with other chemotherapeutic agents, is more likely to result in regression or elimination of the tumor, and less likely to result in the development of more aggressive multidrug resistant tumors than other currently available therapies. Anticancer agents that can be co-administered with the compounds of the invention include Taxol™, also referred to as "paclitaxel", is a well-known anticancer drug which acts by enhancing and stabilizing microtubule formation, and analogs of Taxol™, such as Taxotere™. Compounds that have the basic taxane skeleton as a common structure feature, have also been shown to have the ability' to arrest cells in the G2-M phases due to stabilization or inhibition of microtubules. Other anti-cancer agents that can be employed in combination with the compounds of the invention include Avastin, Adriamycin, Dactinomycin, Bleomycin, Vinblastine. Cisplatin, acivicin; aclarubicin; acodazole hydrochloride; acronine; adozelesin; aldesleukin; altretamine; ambomycin; ametantrone acetate; aminoglutethimide; amsacrine; anastrozole; anthramycin; asparaginase; asperlin; azacitidine; azetepa; azotomycin; batimastat; benzodepa; bicalutamide; bisantrene hydrochloride; bisnafide dimesylate; bizelesin; bleomycin sulfate; brequinar sodium; bropiritnine; busulfan; cactinomycin; calusterone; caracemide; carbetimer; carboplatin; carmustine; carubicin hydrochloride; carzelesin; cedefingol; chlorambucil; cirolemycin; cladribine; crisnatol mesylate; cyclophosphamide; cytarabine; dacarbazine; daunorubicin hydrochloride; decitabine; dexorrnaplatin; dezaguaninc; dezaguanine mesylate; diaziquone; doxorubicin; doxorubicin hydrochloride; droloxifene; droloxifene citrate; dromostanolone propionate; duazomycin; edatrexate; eflornithine hydrochloride; elsamitrucin; enloplatin; enpromate; epipropidine; epirubicin hydrochloride: erbulozole; esorubicin hydrochloride; estramustine; estramustine phosphate sodium; etanidazole; etoposide; etoposide phosphate; etoprine; fadrozole hydrochloride; fazarabine; fenretinide; floxurildine; fludarabine phosphate; fluorouracil; flurocitabine; fosquidone; fostriecin sodium; gemcitabine; gemcitabine hydrochloride: hydroxyurea; idarubicin hydrodhloride; ifosfamide; ilmofosine; interleukin il (deluding recombinant interleukin II, or rIL2), interferon alfa-2a; interferon alfa-2b; interferon alfa-nl ; interferon alfa-n3; interferon beta-I a; interferon gamma-l b; iproplatin; irinotecan hydroQhloride; lanreotide acetate; letrozole; leuprolide acetate; liarozole hydrodhloride; lometrexol sodium; lomustine; losoxantrone hydrochloride; masoprocol; maytansine; mechlorethamine hydrochloride; megestrol acetate; melengestrol acetate; melphalan; menogaril; mercaptopurine; methotrexate; methofrexate sodium; metoprine; meturedepa; mirindomide; mitocarcin; mitocromin; mitogillin; tnitomalcin; mitomycin; mitosper; mitotar.e; mitoxantrone hydrochloride; mycophenolic acid; nocodazole; nogalamycin; ormaplatin; oxisuran: pegaspargase; peliomycin; pentamustine; peplomycin sulfate; perfosfamide; pipobcoman; piposulfan; piroxantrone hydrochlonde; plicamycin; plomestane; porfimer sodium; porfiromycin; prednimustine; procarbazine hydrochloride; puromycin; puromycin hydrochloride; pyrazofurin; riboprine; rogletimide; safingcl; safmgol hydrochloride; semustine; simtrazene; sparfosate sodium; sparsomycin; spirogermanium hydrochloride; spiromustine; spiroplatin; streptonigrin; streptozocin; sulofenur; talisotnycin; tecogalan sodium; tegafur; teloxantrone hydrochloride; temoporfin; teniposide; teroxirone; testolactone; thiamiprhe; thioguanine; thiotepa; tiazofurin; tirapazamine; toremifene citrate; trestolone acetate; triciribine phosphate; trimetrexate; trimetrexate glucuronate; triptorelin; tubulozole hydrochloride; uracil mustard; uredepa; vapreotide; verteporfin; vinblastine sulfate; vinciistine sulfate; vindesine; vindesine sulfate; vinepidine sulfate; vinglycinate sulfate; vinleurosine sulfate; vinorelbine tartrate; vinrosidine sulfate; vinzolidine sulfate; vorozole; zeniplatin; zinostatin; zorubicin hydrochlori Je. I Other anti-cancer drugs that can be employed in combination with the compounds of the invention include: 20-epi-l,25 dihydroxyvitamin D3; 5- ethynyluracil; abiraterone; aclarubicin; acylfulvene; adecypenol; adozelesin; aldesieukin; ALL-TK antagonists; aitretamine; ambamustine; amidox; amifostine; aminolevulinic acid; amrubicin; amsacrine; anagrelide; anastrozole; andrographolide; angiogenesis inhibitors; antagonist D; antagonist G; antarelix: antidorsalizing morphogenetic protein-1; antiandrogen, prostatic carcinoma; antie$trogen; antineoplaston; antisense oligonucleotides; aphidicolin glycinate; apopiosis gene modulators; apoptosis regulators; apurinic acid; ara-CDP-DL-PTBA; arginine deaminase; asulacrine; atamestane; atrimustine; axinastatin 1; axinastatin 2; axinastatin 3; azasetron; azatoxin; azatyrosine; baccatin III derivatives; balanol; batimastat; BCR ABL antagonists; benzochlorins; benzoylstaurosporine; beta lactam derivatives; beta-alethine; betaclamycin B; betulinic acid; bFGF inhibitor; bicalutamide; bisantrene; bisaziridinylspermine; bisnafide; bistratene A; bizelesin; breflate; bropinmine; budotitane; buthionine sulfoximine; calcipotriol; calphostin C; camptothecin derivatives; canarypox IL-2; capecitabine; carboxamide-aminotriazale; carbox> amidotriazole; CaRest M3; CAKN 700; cartilage derived inhibitor; carzelesin; casein kinase inhibitors (ICOS); castanospermine; cecropin B; cetrorelix; chlorlns: chlorcquinoxaline sulfonamide; cicaprost: cis-porphyrin; cladribine; clomjfene analogues; clotrimazole; collismycin A: collismycin B; combretastatin A4; combretastatin analogue; conagenin; crambescidin 816; crisnatol; cryptophycin 8; cryptophycin A derivatives; curacin A; cyclopentanthraquinones; cycloplatam; cypemycin; cytarabine ocfosfate; cytolytic factor: cytostatin; dacliximab; decitabine; dehydrodidemnin B; deslorelin; dexamethasone; dexifosfamide; dexrazoxane; dexv rapamil; diaziquone; didemnin B; didox; diethylnorspermine; dihydro-5- azacytidine; 9- dioxamycin; diphenyl spiromustine; docosanol; dolasetron; doxifluridine; droloxifene; dronabinol; duocarmycin SA; ebselen; ecomustine; edelfosine; edrecolomab; eflornithine; elemene; emitefur; epirubicin; epristeride; estramiistine analogue; estrogen agonists; estrogen antagonists; etanidazole; etopostde phosphate; exemestane; fadrozole; fazarabine; fenretinide; filgrastim; fmasteride; flavopiridol; flezelastine; fluasterone; fludarabine; fluorodaunorunicin hydrochloride; forfenimex; fornestane; fostriecin; fotemustine; gadolinium texaphyrin; gallium nitrate; galocitabine; ganirelix; gelatinase inhibitors; gemcitfcbine; glutathione inhibitors; hepsulfam; heregulin; hexamethylene bisacetamide; hypericin; ibandronic acid; idarubicin; idoxifene; idramantone; ilmofosine; ilomastat; imidazoacridones; imiquimod; immunostimulant peptides; insulin*like growth factor-1 receptor inhibitor; interferon agonists; interferons; interlewkins; iobenguane; iododoxorubicin; ipomeanol, 4-; iroplact; irsogladine; isobengazole; isohomohalicondrin B; itasetron; jasplakinolide; kahalalide F; lamellarin-N triacetate; lanreotide; leinamycin; lenograstim; lentinan sulfate; leptolstatin; letrozole; leukemia inhibiting factor, leukocyte alpha interferon; leuprolide+estrogen+progesterone; leuprorelin; levamisole; liarozole; linear polyamine analogue; lipophilic disaccharide peptide; lipophilic platinum compounds; lissoclinamide 7; lobaplatin; lombricine; lometrexol; lonidamine; losoxaittrone; lovastatin; loxoribine; lurtotecan; lutetium texaphyrin; lysofylline; lytic poptides; maitansine; mannostatin A; marimastat; masoprocol; maspin; matrilysin inhibitors; matrix metalloproteinase inhibitors; menogaril; merbarone; meterelin; methioninase; metoclopramide; MIF inhibitor; mifepristone; miltefosine; mirimastim; mismatched double stranded RNA; mitoguazone; mitolactol; mitomycin analogues; mitonafide; mitotoxin fibroblast growth factor-saporin; mitoxantrone; mofarotene; molgramostim; monoclonal antibody, human chorionic gonadatrophin; monophosphoryl lipid A+myobacterium cell wall sk; mopidamol: multiple drug resistance gene inhibitor; multiple tumor suppressor 1 -based therapy; mustard anticancer agent; mycaperoxide B; mycobacterial cell wall extract; myriaporone; N-acetyldinaline; N-substituted benzamides; nafarelin; nagrestip; naloxone+pentazocine; napavin; naphterpin; nartograstim; nedaplatin; nemorubicin; neridronic acid; neutral endopeptidase; nilutamide; nisamycin; nitric oxide modulators; nitroxide antioxidant; nitrullyn; 06-benzylguanine; octreotide; okicenone; oligonucleotides; onapristone; ondansetron; ondansetron; oracin; oral cytokihe inducer: orniaplatin; osaterone; oxaliplatin; oxaunomycin; palauamine; palmitoylrhizoxin; pamidronic acid: panaxytriol; panomifene; parabactin; pazelljptine; pegaspargase; peldesine; pentosan pclysulfate sodium; pentostatin; pentrozole; perflubron; perfosfamide; perillyl alcohol; phenazinomycin; phenyjacetate; phosphatase inhibitors; picibanil; pilocarpine hydrochloride; pirarubicin; piritrexim; placetin A; placetin B; plasminogen activator inhibitor; platinum complex; platinum compounds; platinum-triamine complex; porfimer sodium; porfirom>cin; prednisone; propyl bis-acridone; prostaglandin J2; proteasome inhibitors; protein A-based immune modulator; protein kinase C inhibitor: protein kinase C inhibitors, microalgal; protein tyrosine phosphatase inhibitors: purine rmcleoside .phosphorylase inhibitors; purpnrins; pyrazoloacridine; pyridoxylated hemoglobin polyoxyethylene conjugate; raf antagonists; raltitrexed; ramosetron; ras famesyl protein transferase inhibitors; ras inhibitors; ras-GAP inhibitor; retelliptine demethylated; rhenium Re IS6 etidronate; rhizoxin; ribozymes; RJI retinamide; rogietimide; rohitukine; romurtide; roquinimex; rubiginone Bl; ruboxyl; safingol; saintopin; SarCNU; sarcophytol A; sargramostim; Sdi 1 mimetics; semustine; senescence derived inhibitor 1; sense oligonucleotides; signal transdpction inhibitors; signal transduction modulators; single chain antigen-binding protein; sizofiran: sobuzoxane; sodium borocaptate; sodium phenylacetate; solverol; somatornedin binding protein; sonermin; spariosic acid; spicamycin D; spiromustine; spler.opentin; spongistatin 1; squalamine; stem cell inhibitor; stem-cell division inhibitors; stipiamide; stromelysin inhibitors; sulfinosine; superactive vasoactive intestinal peptide antagonist; suradista; suramin; swainsonine; synthetic glycosaminoglycans; tallimustine; tamoxifen methiodide; tauromustine; tazarotene; tecogajan sodium: :egafur; tellurapyrylium; telomerase inhibitors; temoporfin; temozOlomide; teniposide; tetrachlorodecaoxide; tetrazomine; thaliblastine; thiocoraline; throrr.bopoietin; thrombopoietin mimetic; thymalfasin; thymopoietin receptor agonist; thymotrinan; thyroid stimulating hormone; tin ethyl etiopurpurin: tirapazsamine; titanocene bichloride; topsentin; toremifene; totipotent stem cell factor; translation inhibitors; tretinoin; triaceu luridine; triciribine; trimetrexate; triptoreiin: tropisetron; turosteride; tyrosine kinase inhibitors; tyrphostins; UBC inhibitors; ubenimex; urogenital sinus-derived growth inhibitory factor; urokinase receptor antagonists; vapreotide; variolin B; vector system, erythrocyte gene therapy; velarcsol; veramine; verdtr.s; verteporfin; vinorelbine; vinxaltine; vitaxin; voroz0!e; zanoterone; zeniplatin; zilascorb; and zinostatin stimalamer. Preferred anti-cancer drugs are 5-fluorouracil and leucovorin. Other chtmotherapeutic agents that can be employed in combination with the compounds of the invention include but are not limited to alkylating agents, antimfctabolites, natural products, or hormones. Examples of alkylating agents useful for the treatment or prevention of T-cell malignancies in the methods and compositions of the invention include but are not limited to, nitrogen mustards (e.g., mechlbroethamine, cyclophosphamide, chlorambucil, etc.), alkyl sulfonates (e.g., busullan), nitrosoureas (e.g., carmustine, lomusitne, etc.), ortriazenes (decarbazine, etc.). Examphs of antimetabolites useful for the treatment or prevention of T-cell malignancies in the methods and compositions of the invention include but are not limited to folic acid analog (e.g., methotrexate), or pyrimidine analogs (e.g., Cytarfcbine), purine analogs (e.g., mercaptopurine, thioguanine, pentostatin). Examjples of natural products useful for the treatment or prevention of T-cell malignancies in the methods and compositions of the invention include but are not limited to vinca alkaloids (e.g., vinblastin, vincristine), epipodophyllotoxins (e.g., etoposide), antibiotics (e.g., daunorubicin, doxorubicin, bleomycin), enzymes (e.g.. L-asparaginase), or biological response modifiers (e.g., interferon alpha). Examples of alkylating agents that can be employed in combination with the compounds of the invention include but are not limited to, nitrogen mustards (e.g., mechloroethamine,, cyclophosphamide, chlorambucil, melphalan, etc.), ethylenimine and nlethylmelamines (e.g., hexamethlymelamine, thiotepa), alkyl sulfonates (e.g., busuifan), nitrosoureas (e.g., carmustine, lomusitne, semustine, streptozocin, etc.), or rriazenes (decarbazine, etc.). Examples of antimetabolites useful for the treatment or prevention of cancer in the methods and compositions of the invention include but are not limited to folic acid analog (e.g., methotrexate), or pyrimidine analogs (e.g., fluorouracil, floxouridine, Cytarabine), purine analogs (e.g., mercaptopurine, thioguanine, pentostatin). Examples of natural products useful for the treatment or prevention of cancer in the methods and compositions of the invention include but are not limited to vinca alkaloids (e.g., vinblastin, vincristine), epipodophyllotoxins (e.g., etoposide, teniposide), antibiotics (e.g., actinomycin D, daunorubicin, doxofubicin, bleomycin, plicamycin, mitomycin), enzymes (e.g., L-asparaginase), or biological response modifiers (e.g,, interferon alpha). Examples of hormones ar.d antagonists useful for the treatment or prevention of cancer in the methods and compositions of the invention include but are not limited to adrenocorticosteroids (e.g.,prednisbne), progestins (e.g., hydroxyprogesterone caproate, megestrol acetate, medroxyprogesterone acetate), estrogens (e.g., diethlystilbestrol, ethinyl estradiol), antieatrogen (e.g., tamoxifen), androgens (e.g., testosterone propionate, fluoxymesterone), antiandrogen (e.g., flutamide), gonadotropin releasing hormone analog (e.g., leuprolide). Other agents that can be used in the methods and compositions of the invention for the treatment or prevention of cancer include platinum coordination complexes (e.g., cisplatin, carboblatin), anthracenedione '-e.g., mitoxiantrone), substituted urea (e.g., hydroxyurea), methyl hydrazine derivative (e.g., procarbazine), adrenocortical suppressant (e.g., mitotane, aminoglutethimide). Examples of anti-cancer agents which act by arresting cells in the G2-M phases due to stabilization or inhibition of microtubules and which can be used in combination with the compounds of the invention include without limitation the following marketed drugs and drugs in development: Erbulozole (also known as R- 55104), Dolastatin 10 (also known as DLS-10 and NSC-376128), Mivobulin isethionate (also known as CI-980), Vincristine, NSC-639829, Discodermolide i also known as NVP-XX-A-296), ABT-751 (Abbott, also known as E-7010), Altorhyrtins (such as Altorhynin A and Altorhyrtin C), Spongistatins (such as Spongistatin !. Spongistatin 2, Spongistatin 3, Spongistatin 4, Spongistatin 5, Spongistatin 6, Spongistatin 7, Spongistatin 8, and Spongistatin 9), Cemadotin hydrochloride (aiso knowii as LU-103 793 and NSC-D-669356), Epothilones (such as Epothilone A. Epothilone B, Epothilone C (also known as desoxyepothilone A or dEpoA), Epothilone D (also referred to as KOS-862, dEpoB, and desoxyepothilone B ). Epothilone E, Epothilone F, Epothilone B N-oxide, Epothilone A N-oxide, 16-azaepoth| lone B, 21-aminoepothilone B (also known as BMS-310705), 21- hydroKyepothilone D (also known as Desoxyepothilone F and dEpoF), 26- fluorospothilone), Auristatin PE (also known as NSC-654663), Soblidotin (also known as TZT-1027), LS-4559-P (Pharmacia, also known as LS-4577), LS-457-S (Phannacia, also known as LS-477-P), LS-4477 (Phannacia), LS-4559 (Pharmacia), RPR-112378 (Aver.iis), Vincristine sulfate. DZ-3358 (Daiichi), FR-182877 (Fujisawa, also known as WS-9885B), GS-164 (Takeda), GS-198 (Takeda), KAR-2 (Hungarian Academy of Sciences), BSF-223651 (BASF, also known as ILX-651 and LU-223651), SAH-49960 (Liliy/Novartis), SDZ-268970 (Lilly/Novartis), AM- 97 (Aismad/Kyowa Hakko), AM-132 (Armad), AM-138 (Armad/Kyowa Hakko), E>N-5i005 (Indena). Cryptophycin 52 (also known as LY-355703), AC-7739 (Ajinomoto, also kno\vn as AVE-8063A and CS-39.HC1), AC-7700 (Ajinomoto, also known as AVE-8062, AVE-8062A, CS-39-L-Ser.HCl, and RPR-258062A), Vitilevuamide, Tubulysin A, Canadensol, Centaureidin (also known as NSC- 106969), T-l 38067 i, Tularik, also known as T-67, TL-138067 and TI-138067), COBRA-1 (Parker Hughes Institute, also known as DDE-261 and WHI-261), H10 (Kansas State University), HI6 (Kansas State University), Oncocidin Al (also known as BTO-956 and DIME), DDE-313 (Parker Hughes Institute), Fijianolide B, Laulinjalide, SPA-2 (Parker Hughes Institute), SPA-1 (Parker Hughes Institute, also known as SPIKET-P), 3-IAABU (Cytoskeieton/Mt. Sinai School of Medicine, also known as MF-569). Narcosine (also known as NSC-5366), Nascapine, D-24851 (Asia Medica), A-105972 (Abbott), Hemiasterlin, 3-BAABU (Cytoskeleton/Mt. Sinai School of Medicine, also known as MF-191), TMPN (Arizona State University), Vanadocene acetylacetonate, T-l38026 (Tularik), Monsatrol, Inanocine (also kmown as NSC-698666), 3-LAABE (C>ioskeleton/Mt. Sinai School of Medicine), A-20417 (Abbott), T-607 (Tularik, also known as T-900607), RPR- 115781 (Aventis), Eieutherobins (such as Desmethyleleutherobin, Desaeifyleieutherobm. Isoeleutherobin A, and Z-EIeutherobin), Caribaeoside, Caribaeolin. Halichondrin B, D-64131 (Asu Medical. D-68144 (Asta Medica), Diazonamide A, A-293620 (Abbott), NPI-2550 (Nereus), Taccalonolide A, TUB- 245 (Aventis), A-259754 (Abbott), Diozostatin, (-)-Phenylahistin (also known as NSCL*96F037), D-6S838 (Asta Medica), D-68836 (Asta Medica), Myoseverin B. D-43411 (Zentaris, also known as D-81862). A-289099 (Abbott), A-318315 (Abbott), HTI-286 i also known as SPA-110. trifluoroacetate salt) (Wyeth), D-82317 (Zentaris), D-82318 i;Zentaris), SC-12983 (NCI), Resverastatin phosphate sodium, BPR-OY-007 (National Health Research Institutes), and SSR-250411 (Sanofi). E. Compositions and Methods for Administering Therapies The present invention provides compositions for the treatment, prophylaxis, and amelioration of proliferative disorders, such as cancer. In a specific embodiment, a composition comprises one or more compounds of the invention, or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or prodrug thereof. In another embodiment, a composition of the invention comprises one or more prophylactic or therapeutic agents other than a compound of the invention, or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug thereof. In another embodiment, a composition of the invention comprises one or more compounds of the invention, or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or prodrug thereof, and one or more other prophylactic or therapeutic agents, la another embodiment, the composition comprises a compound of the invention, or a phartnareutiv^lly acceptable salt, solvate, clathrate, hydrate, or prodrug thereof, and a pharmaceutically acceptable carrier, diluent or excipient. In a preferred embodiment, a composition of the invention is a pharmaceutical composition or a single unit dosage form. Pharmaceutical compositions and dosage forms of the invention comprise one or more active ingredients in relative amounts and formulated in such a way that a given pharmaceutical composition or dosage form can be used to treaf or prevent prolifqrative disorders, such as cancer. Preferred pharmaceutical compositions and dosage forms comprise a compound of formula (I), (II), (III), (IV), (V), (VI), (VII), i VIII), (IX), (X), or Table 1, or a pharmaceutically acceptable prodrug, salt, solvate, clathrate, hydrate, or prodrug thereof, optionally in combination with one or more additional active agents. A pharmaceutical composition of the invention is formulated to be compatible with its intended route of administration. Examples of routes of administration include, but are not limited to, parenteral, e.g., intravenous, intradfcrmal. subcutaneous, oral (e.g., inhalation), intranasal, transdermal (topical), :ransmucosal, and recta! administration. In a specific embodiment, the composition is formulated in accordance with routine procedures as a pharmaceutical composition adapted for intravenous, subcutaneous, intramuscular, oral, intranasal or topical administration to human beings. In a preferred embodinu . a pharmaceutical composition is formulated in accordance with routine procedures for subcutaneous administration to human beings. Single unit dosage forms of the invention are suitable for oral, mucosal (e.g., nasal, sublingual, vagina , buccal, or rectal), parenteral (e.g., subcutaneous, intravenous, bolus injection, intramuscular, or intraarterial), or transdermal administration to a patient. Examples of dosage forms include, but are not limited to: tablets; caplets; capsules, such as soft elastic gelatin capsules; cachets; troches; lozenges; dispersions; suppositories; ointments; cataplasms (poultices); pastes; powdefs; dressings; creams; plasters; solutions; patches; aerosols (e.g., nasal sprays or inhalers); gels; liquid dosage forms suitable for oral or mucosal administration to a patieht, including suspensions (e.g., aqueous or non-aqueous liquid suspensions, oil-in-water emulsions, or a water-in-oil liquid emulsions), solutions, and elixirs: liquid dosage forms suitable for parenteral administration to a patient; and sterile solids (e.g., crystalline or amorphous solids) that can be reconstituted to provide liquid dosage forms suitable for parenteral administration to a patient. The composition, shape, and type of dosage forms of the invention will typically vary depending on their use. For example, a dosage form suitable for mucosal administration may contain a smaller amount of active ingredient(s) than an oral dosage form used to treat the same indication. This aspect of the invention will be realily apparent to those skilled in the art. See, e.g., Remington's Pharmaceutical Sciences (1990) 18th ed., Mack Publishing, Easton PA. Typical pharmaceutical compositions and dosage forms comprise one or more gxcipients. Suitable excipients are well known to those skilled in the art of pharmacy, and non-limiting examples of suitable excipients art provided herein. Whether a particular excipient is suitable for incorporation into a pharmaceutical composition or dosage form depends on a variety of factors well known in the art including, but not limited to, the way in which the dosage form will be administered to a patient. For example, oral dosage forms such as tablets may contain excipients not suited for use in parenteral dosage forms. The suitability of a particular excipient may also depend on the specific active ingredients in the dosage form. For example, the decomposition of some active ingredients can be accelerated by some excipients such as lactose, or when exposed to water. Active ingredients that comprise primary or secondary amines (e.g., N-desmethylvenlafaxine and N,N-didesmethy!venlafaxine) are particularly susceptible to such accelerated decomposition. Consequently, this invention encompasses pharmaceutical compositions and dosage forms that contain little, if any, lactose. As used herein, the term "lactose-free" means that the amount of lactose present, if any, is insufficient to substantially increase the degradation rate of an active ingredient. Lactose-free compositions of the invention can comprise excipients that are well known in the art and are listed, for example, in the U.S. Pharmocopia (TJSP) SP (XXJ)/NF (XVI). In general, lactose-free compositions comprise active ingredients, a binder/filler, and a lubricant in pharmaceutically compatible and pharmaceutically acceptable amounts. Preferred lactose-free dosage forms comprise active ingredients, microcrystalline cellulose, pre-gelatinized starch. and magnesium stearate. This invention further encompasses anhydrous pharmaceutical compositions and dosage forms comprising active ingredients, since water can facilitate the degrad&tion of some compounds. For example, the addition of water (e.g., 5%) is widely accepted in the pharmaceutical arts as a means of simulating long-term storage in order to determine characteristics such as shelf-life or the stability of formulations over time. See, e.g., Jens T. Carstensen (1995) Drug Stability: Principles & Practice. 2d. Ed., Marcel Dekker, NY, NY, 379-80. In effect, water and heat accelerate the decomposition of some compounds. Thus, the effect of water on a formulation can be of great significance since moisture and/or humidity are commonly encountered during manufacture, handling, packaging, storage, shipment, and use of formulations. Anhydrous pharmaceutical compositions and dosage forms of the invention can be prepared using anhydrous or low moisture containing ingredients and low moisture or low humidity conditions. Pharmaceutical compositions and dosage forms that comprise lactose and at least one active ingredient that comprises a primary or secondary amine are preferably anhydrous if substantial contact with moisture and/or humidity during manufacturing, packaging, and/or storage is expected. An anhydrous pharmaceutical composition should be prepared and stored such that its anhydrous nature is maintained. Accordingly, anhydrous compositions are preferably packaged using materials known to prevent exposure to water such that they can be included in suitable formulary kits. Examples of suitable packaging include, but are not limited to, hermetically sealed foils, plastics, unit dose containers (e.g., vials), blister packs, and strip packs. The invention further encompasses pharmaceutical compositions and dosage forms that comprise one or more compounds that reduce the rate by which an active ingredient will decompose. Such compounds, which are referred to herein as "stabilizer"' include, but are not limited to, antioxidants such as ascorbic acid, pH buffers, or salt buffers. I ) Oral Dosage Forms Pharmaceutical compositions of the invention that are suitable for oral administration can be presented as discrete dosage forms, such as, but are not limited to, tablets (e.g., chewable tablets), caplets, capsules, and liquids (e.g., flavored syrup$). Such dosage forms contain predetermined amounts of active ingredients, and may be prepared by methods of pharmacy well known to those skilled in the art. See generally. Remington's Pharmaceutical Sciences (1990) 18th ed., Mack Publishing, Easton PA. Typical oral dosage forms of the invention are prepared by combining the active ingredients) in an admixture with at least one excipient according to conventional pharmaceutical compounding techniques. Excipients can take a wide variety of forms depending on the form of preparation desired for administration. For example, excipients suitable for use in oral liquid or aerosol dosage forms include, but are not limited to, water, glycols, oils, alcohols, flavoring agents, preservatives, and coloring agents. Examples of excipients suitable for use in solid oral dosage forms (e.g., powders, tablets, capsules,, and caplets) include, but are not limited to, starches, sugars, micro-crystalline cellulose, diluents, granulating agents, lubricants, binders, and disintegrating agents. Because of their ease of administration, tablets and capsules represent the most advantageous oral dosage unit forms, in which case solid excipients are employed. If desired, tablets can be coated by standard aqueous or nonaqueous techniques. Such dosage forms can be prepared by any of the methods of pharmacy. In general, pharmaceutical compositions and dosage forms are prepared by uniformly and intimately admixing the active ingredients with liquid carriers, finely dividad solid carriers, or both, and then shaping the prod'ict into the desired presentation if necessary. For example, a tablet can be prepared by compression or molding. Compressed tablets can be prepared by compressing in a suitable machine the active ingredients in a free-flowing form such as powder or granules, optionally mixed with an excipient. Molded tablets can be made by molding in a suitable machine a mixture of the powdered compound moistened with an inert liquid diluent. Examples of excipients that can be used in oral dosage forms of the invention include, but are not limited to, binders, fillers, d is integrants, and lubricants. Binders suitable for use in pharmaceutical compositions and dosage forms include, but are not limited to, corn starch, potato starch, or other starches, gelatin, natural and synthetic gums such as acacia, sodium alginate, alginic acid, other alginates, powdered tragacanth, guar gum, cellulose and its derivatives (e.g., ethyl cellulose, cellulose acetate, carboxymethyl cellulose calcium, sodium carboxymethyl cellulose), polyvinyl pyrrolidone, methyl cellulose, pre-gelatinized starch, hydroKypropyl methyl cellulose, (e.g., Nos. 22Q8,2906, 2910), microcrystalline cellulose, and mixtures thereof. Suitable forms of microcrystalline cellulose include, but are not limited to, the materials sold as AVICEL-PH-101, AVICEL-PH-103 AVICEL RC-581, AVIGEL-PH-105 i available from FMC Corporation, American Viscose Division, Avicel Sales, Marcus Hook, PA), and mixtures thereof. One specific binder is a mixture of microcrystalline cellulose and sodium carboxymethyl cellulose sold as AVICEL RC-581, Suitable anhydrous or low moisture excipients or additives include AVICEL-PH-103J and Starch 1500 LM. Examples of fillers suitable for use in the pharmaceutical compositions and dosage forms disclosed herein include, but are not limited to, talc, calcium carbonate (e.g., granules or powder), microcrystalline cellulose, powdered cellulose, dextrates, kaolin, mannitol. silicic acid, sorbitol, starch, pre-gelatinized starch, and mixtures thereof. The binder or filler in pharmaceutical compositions of the invention is typically present in from about 50 to about 99 weight percent of the pharmaceutical composition or dosage form. Disintegrants are used in the compositions of the invention to provide tablets that disintegrate when exposed to an aqueous environment. Tablets that contain too much disintegrant may disintegrate in storage, while those that contain too little may not disintegrate at a desired rate or under the desired conditions. Thus, a sufficient amourtt of disintegrant that is neither too much nor too little to detrimentally alter the release of the active ingredients should be used to form solid oral dosage forms of the invention. The amount of disintegrant used varies based upon the type of formulation, and is readily discernible to those of ordinary skill in the art. Typical pharmaceutical compositions comprise from about 0.5 to about 15 weight percen: of. disintegrant, preferably from about 1 to about 5 weight percent of disintegrant. Disintegrants that can be used in pharmaceutical compositions and dosage forms of the invention include, but are not limited to, agar-agar, algiric acid, calcium carbonate, microcrystalline cellulose, croscarmellose sodium, crospovidcne, polacrjlin potassium, sodium starch glycolate, potato or tapioca starch, other starches, pre-gelatinized starch; other starches, clays, other algins, other celluloses, gums, and mixtures thereof. Lubricants that can be used in pharmaceutical compositions and dosage forms of the invention include, but are not limited to, calcium stearate. magnesium stearate, mineral oil. light mineral oil, glycerin, sorbitol, mannitol. polyethylene glycol, other glycols, stearic acid, sodium lauryl sulfate, talc, hydrogenated vegetable oil (e.g., peanut oil, cottonseed oil, sunflower oil. sesame oil, olive oil. corn oil, and soybean oil), zinc stearate, ethyl oleate, ethyl laureate, agar, and mixtures thereof. Additional lubricants include, for example, a syloid silica gel (AEROSIL 200, manufactured by W.R. Grace Co. of Baltimore, MD). a coagula:?d aerosol of synthetic silica (marketed by Degussa Co. of Piano, TX), CAB-O-SIL a pyroganic silicon dioxide product sold by Cabot Co. of Boston, MA), and mixtures thereof. If used at all, lubricants are typically used in an amount of less than about 1 weight percent of the pharmaceutical compositions or ddsage forms into which they are incorporated. 2) Controlled Release Dosage Forms Active ingredients of the invention can be administered by controlled release means or by deliver.' devices that are well known to those of ordinary skill in the art. Examples include, but are not limited to, those described in U.S. Patent Nos.: 3,845,770; 3,916,899; 3,536,809; 3,598,123; and 4,008,719, 5,674,533, 5,059,595, 5,591,767, 5,120,548, 5,073,543, 5,639,476, 5,354,556, and 5,733,566, each of which is incorporated herein by reference. Such dosage forms can be used to provide slow or controlled-release of one or more active ingredients using, for example, hydropropylmethyl cellulose, other polymer matrices, gels, permeable membranes, osmotic systems, multilayer coatings, microparticles, liposomes, microspheras, or a combination thereof to provide the desired release profile in varying proportions. Suitable controlled-release formulations known to those of ordinary skill in the art, including those described herein, can be readily selected for use with the active ingredients of the invention. The invention thus encompasses single unit dosage farms ruitable for oral administration such as, but not limited to, tablets capsules, gelcaps, and caplets that are adapted for controlled-release. All controlled-release pharmaceutical products have a common goal of improving drug therapy over that achieved by their non-controlled counterparts. Ideally, the use of an optimally designed controlled-release preparation in medical treatment is characterized by a minimum of drug substance being employed to cure or control the condition in a minimum amount of time. Advantages of controlledreleasa formulations include extended activity of the drug, reduced dosage frequency, and increased patient compliance. Most controiled-release formulations are designed to initially release an amount of drug (active ingredient) that promptly produces the desired therapeutic effect, and gradually and continually release of other amounts of diug to maintain this level of therapeutic or prophylactic effect over an extended period of time. In order to maintain this constant level of drug in the body, the drug must be released from the dosage form at a rate that will replace the amount of drug being metabolized and excreted from the body. Controlled-release of an active ingredient can be stimulated by various conditions including, but not limited to, pH, temperature, enzymes, water, or other physiological conditions or compounds. A particular extended release formulation of this invention comprises a therapeutically or prophylactically effective amount of a compound of formula (1), (II), (JIII), (IV), (V), (VI), (VII), (VIII), (IX), (X), or Table 1, or a pharmaceutically acceptable salt, solvate, hydrate, c'athrate, or prodrug thereof, in spheroids which further comprise microcrystalline cellulose and, optionally, hydroxypropylmethyli cellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose. Such extended release formulations can be prepared acconding to U.S. Patent No. 6,274,171, the entirely of which is incorporated herein by reference. A specific controlled-release formulation of this invention comprises from about 6% to about 40% a compound of formula (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or Table 1, or a pharmaceutically acceptable salt, solvate, hydrate, clathfate, or prodrug thereof, by weight, about 50% to about 94% microcrystalline cellulose, NF, by weight, and optionally from about 0.25% to about 1% by weight of hydroxypropyl-methylceilulose, USP, wherein the spheroids are coated with a film coatiig composition comprised of ethyl cellulose and hydroxypropylmethylcellulose. 3) Parenteral Dosage Forms Parenteral dosage forms can be administered to patients by various routes including, but not limited to, subcutaneous, intravenous (including bolus injection), intramuscular, and intraarterial. Because their administration typically bypasses patients' natural defenses against contaminants, parenteral dosage forms are preferably sterile or capable of being sterilized prior to administration to a patient. Examples of parenteral dosage forms include, but are not limited to, solutions ready for injection, dry products ready to be dissolved or suspended in a pharmaceutically acceptable vehicle for injection, suspensions ready for injection, and emulsions. Suitable vehicles that can be used to provide parenteral dosage forms of the invention are well known to those skilled in the art. Examples include, but are not limited to: Water for Injection USP; aqueous vehicles such as, but not limited to, Sodium Chloride Injection, Ringer's Injection, Dextrose Injection, Dextrose and Sodium Chloride Injection, and Lactated Ringer's Injection; water-miscible vehicles such as, but not limited to, ethyl alcohcl, polyethylene glycol, and polypropylene glycol; and non-aqueous vehicles such as, but not limited to, corn oil, cottonseed oil, peanut oil, sesame oil, ethyl oleate, isopropyl myristate, and benzyl benzoate. Compounds that increase the solubility of one or more of the active ingredients disclosed herein can also be incorporated into the parenteral dosage forms of the invention. 4) Transdermal. Topical, and Mucosal Dosage Forms Transdermal, topical, and mucosal dosage forms of the invention include, but are not limited to. ophthalmic solutions, sprays, aerosols, creams, lotions, ointments, gels, solutions, emulsions, suspensions, or other forms known to one of skill in the art. See, e.g., Remington's Pharmaceutical Sciences (1980 & 1990) 16th and 18th eds., Mack Publishing, Easton PA and Introduction to Pharmaceutical Dosage Form$ (1985) 4th ed., Lea & Febiger, Philadelphia. Dosage forms suitable for treating mucosal tissues within the oral cavity can be formulated as mouthwashes or as oral gels. Further, transdermal dosage forms include "reservoir type" or "matrix type" patches, which can be applied to the skin and worn for a specific period of time «o permit the penetration of a desired amount of active ingredients. Suitable excipients (e.g., carriers and diluents) and other materials that can be used to provide transdermal, topical, and mucosal dosage forms encompassed by this invention are well known to those skilled in the pharmaceutical arts, and depend on the particular tissue to which a given pharmaceutical composition or dosage form will be applied. \Vith that fact in mind, typical excipients include, but are not limited to, water, acetone, ethanol, ethylene glycol, propylene glycol, butane-1,3- diol, isopropyl rmristate, isopropyl palmitate, mineral oil, and mixtures thereof to form lotions, tinctures, creams, emulsions, gels or ointments, which are non-toxic and pharmaceutically acceptable. Moisturizers or humectants can also be added to pharmaceutical compositions and dosage forms if desired. Examples of such additional ingredients are well known in the art. See, e.g., Remington's Pharmaceutical Sciences (1980 & 1990) 16th and 18th eds., Mack Publishing, Eastern PA. Depending on the specific tissue to be treated, additional components may be used pfior to, in conjunction with, or subsequent to treatment with active ingredients of the invention. For example, penetration enhancers can be used to assist in delivering the active ingredients to the tissue. Suitable penetration enhancers include, but are not limited to: acetone; various alcohols such as ethanol, oleyl, and tetrahydrofuryl; alkyl sulfoxides such as dimethyl sulfoxide; dimethyl acetamide; dimethyl formamide; polyethylene glycol; pyrrolidones such as polyvinylpyrrolidone: Kollidon grades (Povidone, Polyvidone); urea; and various water-soluble or insoluble sugar esters such a Tween 80 (polysorbate 80) and Span 60 (soribitan monostearate). The pH of a pharmaceutical composition or dosage form, or of the tissue to which the pharmaceutical composition or dosage form is applied, may also be adjusted to improve delivery of one or more active ingredients. Similarly, the polarity of a solvent rarrier, its ionic strength, or tonicity can be adjusted to improve delivery. Compounds such as stearates can also be added to pharmaceutical T compositions or dosage forms to advantageously alter the hydrophilicity or lipophilicity of one or more active ingredients so as to improve delivery. In this regard, stearates can serve as a lipid vehicle for the formulation, as an emulsifying agent or surfactant, and as a delivery-enhancing or penetration-enhancing agent. Different salts, hydrates or solvates of the active ingredients can be used to further adjust {he properties of the resulting composition. 5) Dosage & Frequency of Administration The amount of the compound or composition of the invention which will be effective in the prevention, treatment, management, or amelioration of a proliferative disorders, such as cancer, or one or more symptoms thereof, will vary with the nature and severity of the disease or condition, and the route by which the active ingredient is administered. The frequency and dosage will also vary according to factors specific for each patient depending on the specific therapy (e.g., therapeutic or prophylactic agents) administered, the severity of the disorder, disease, or condition, the route of administration, as well as age, body, weight, response, and the past medical history of the patient. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems. Suitable regiments can be selected by one skilled in the art by considering such factors and by following, for example, dosages reported in the literature and recommended in the Physician's Desk Reference (57th ed., 2003). Exemplary doses of a small molecule include milligram or n icrogram amounts of the small molecule per kilogram of subject or sample weight (e.g., about 1 miqrogram per kilogram to about 500 milligrams per kilogram, about 100 micrograms per kilogram to about 5 milligrams per kilogram, or about 1 microgram per kilogram to about 50 micrograms per kilogram). In general, the recommended daily dose range of a compound of the invention for the conditions described herein lie within the range of from about 0.01 mg to about 1000 m§ per day, given as a single once-a-day dose preferably as divided doses throughout a day. In one embodiment, the daily dose is administered twice daily in equally divided doses. Specifically, a daily dose range should be from about 5 mg to about 500 mg per day, more specifically, between about 10 mg and about 200 mg per day. In managing the patient, the therapy should be initiated at a lower dose, perhaps about 1 mg to about 25 mg, and increased if necessary up to about 200 mg to about 1000 mg per day as either a single dose or divided doses, depending on the patient's global response. It may be necessary to use dosages of the attive ingredient outside the ranges disclosed herein in some cases, as will be appafent to those of ordinary skill in the art. Furthermore, it is noted that the clinician or treating physician will know how and when to interrupt, adjust, or terminate therapy in conjunction with individual patient response. Different therapeutically effective amounts may be applicable for different proliferative disorders, as will be readily known by those of ordinary skill in the art. Similarly, amounts sufficient to prevent, manage, treat or ameliorate such proliferative disorders, but insufficient to cause, or sufficient to reduce, adverse effects associated with the'compounds of the invention are also encompassed by the above described dosage amounts and dose frequency schedules. Further, when a patient is administered multiple dosages of a compound of the invention, not all of the dosages need be the same. For example, the dosage administered to the patient may be increased to improve the prophylactic or therapeutic effect of the compound or it may be decreased to reduce one or more side effects that a particular patient is experiencing. In a specific embodiment, the dosage of the composition of the invention or a compound of the invention administered to prevent, treat, manage, or ameliorate a proliferative disorders, such as cancer, or one or more symptoms thereof in a patient is 150 ug/kg, preferably 250 ug/kg, 500 ug/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 25 mg/k§, 50 mg/kg. 75 mg/kg, 100 mg/kg, 125 mg/kg, 150 mg/kg, or 200 mg/kg or more of a patient's body weight. In another embodiment, the dosage of the composition of the invention or a compound of the invention administered to prevent, treat, manage, or ameliorate a proliferative disorders, such as cancer, or one or mote symptoms thereof in a patient is a unit dose of 0.1 mg to 20 mg, 0.1 mg to 15 mg, 0.1 mgto 12 mg, 0.1 mgto lOmg, 0.1 mg to 8 mg, 0.1 mgto7mg, 0.1 mg to 5 mg, 0.1 to 2.5 mg, 0.25 mg to 20 mg, 0.25 to 15 mg, 0.25 to 12mg, 0.25 to 10 mg, 0.25 to 8 mg. 0.25 mg to 7m g, 0.25 mg to 5 mg, 0.5 mg to 2.5 mg, 1 mg to 20 mg, 1 mg to 15 mg, 1 mg to 12 mg, 1 mg to 10 mg, 1 mg to 8 mg, 1 mg to 7 mg, 1 mg to 5 mg, or 1 mg to 2.5 mg. The dosages of prophylactic or therapeutic agents other than compounds of the invention, which have been or are currently being used to prevent, treat, manage, or proliferative disorders, such as cancer, or one or more symptoms thereof can be used ia the combination therapies of the invention. Preferably, dosages lower than those which have been or are currently being used to prevent, treat, manage, or ameliorate a proliferative disorders, or one or more symptoms thereof, are used in the combination therapies of the invention. The recommended dosages of agents currently used for the prevention, treatment, management, or amelioration of a proliferative disorders, such as cancer, or one or more symptoms thereof, can obtained from any reference in the art including, but not limited to, Hardman e: al, eds., 1996, Goodman & Oilman's The Pharmacological Basis Of Basis Of Therapeutics 9th Ed. Mc-Craw-Hill, New York; Physician's Desk Reference (PDR) 57th EL, 2003, Medical Economics Co., Inc., Montvale, NJ, which are incorporated herein by reference in its entirety. In certain embodiments, when the compounds of the invention are administered in combination with another therapy, the therapies (e.g., prophylactic or therapeutic agents) are administered less than 5 minutes apart, less than 30 minutes apart, 1 hour apart, at about 1 hour apart, at about 1 to about 2 hours apart, at about 2 hours to about 3 hours apart, at about 3 hours to about 4 hours apart, at about 4 hours to about 5 hours apart, at about 5 hours to about 6 hours apart, at about 6 hours to about 7 hours apart, at about 7 hours to about 8 hours apart, at about 8 hours to about 9 hours apart, at about 9 hours to about 10 hours apart, at about 10 hours to about 11 hours apart, at about 11 hours to about 12 hours apart, at about 12 hours to 18 hours apart, 18 hours to 24 hours apart, 24 hours to 36 hours apart, 36 hours to 48 hours apart, 48 hours to 52 hours apart, 52 hours to 60 hours apart. 60 hours to 72 hours apart, 72 hours to 84 hours apart, 84 hours to 96 hours apart, or 96 hours to 120 hours part. In one embodiment, two or more therapies (e.g., prophylactic or therapeutic agents) are administered within the same patent visit. In certain embodiments, one or more compounds of the invention and one or more other the therapies (e.g., prophylactic or therapcat'c agents) are cyclically administered. Cycling therapy involves the administration of a first therapy (e.g., a first prophylactic or therapeutic agents) for a period of time, followed by the administration of a second therapy (e.g., a second prophylactic or therapeutic agents) for a period of time, followed by the administration of a third therapy (e.g., a third prophylactic or therapeutic agents) for a period of time and so forth, and repeating this sequential administration, i.e., the cycle in order to reduce the development of resistance to one of the agents, to avoid or reduce the side effects of one of the agents, and/or to improve the efficacy of the treatment. In certain embodiments, administration of the same compound of the invention may be repeated and the administrations may be separated by at least 1 day, 2 days, 3 days. 5 days, 10 days, 15 days, 30 days, 45 days, 2 months, 75 days, 3 months, or 6 months. In other embodiments, administration of the same prophylactic or therapeutic agent may be repeated and the administration may be separated by at least at least 1 day, 2 days, 3 days, 5 days, 10 days, 15 days, 30 days, 45 days, 2 months, 75 aays, 3 months, or 6 months. In a specific embodiment, the invention provides a method of preventing, treating, managing, or ameliorating a proliferative disorders, such as cancer, or one or more symptoms thereof, said methods comprising administering to a subject in need thereof a dose of at least 150 ug/kg, preferably at least 250 ng/kg, at least 500 ug/kg, at lea 1 mg/kg, at least 5 mg/kg, at least 10 mg/kg, at least 25 mg/kg, at least 50 mg/kg, at least 75 mg/kg, at least 100 mg/kg, at least 125 mg/kg, at least 150 mg/kg, or at least 200 mg/kg or more of one or more compounds of the invention once every day, preferably, once every 2 days, once ever 3 days, once every 4 days, once every 5 days, once every 6 days, once every 7 days, once every 8 days, once every 10 days, once every two weeks, once every three weeks, or once a month. F. Other Embodiments The compounds of the invention may be used as research tools (for example, to evaluate the mechanism of action of new drug agents, to isolate new drug discoviery targets using affinity chromatography. as antigens in an ELISA or ELISAlike assay, or as standards in in vitro or in vivo assays). These and other uses and embodiments of the compounds and compositions of this invention will be apparent to those of ordinary skill in the art. The invention is further defined by reference to the following examples describing in detail the preparation of compounds of the invention. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the purpose and interest of this invention. The foilowing examples are set forth to assist in understanding the invention and should not be construed as specifically limiting the invention described and claimed herein. Such variations of the invention, including the substitution of all equivalents now known or later developed, which would be within the purview of those skilled in the art, and changes in formulation or minor changes in experimental design, are to be considered to fall within the scope of the invention incorporated herein. EXAMPLES Reagents and solvents used below can be obtained from commercial sources such as Aldrich Chemical Co. (Milwaukee, Wisconsin, USA). 'H-NMR and 13CNMR spectra were recorded on a Varian 300MHz NMR spectrometer. Significant peaks are tabulated in the order: 6 (ppm): chemical shift, multiplicity (s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet; br s, broad singlet), coupling constant(s) in Hertz (Hz) and number of protons. Example 1: Synthesis of Compound 76 (Figure Removed) The hydrazide (M) (1.45 g, 7.39 mmol) and the isothiocyanate (N) (1.59 g, 7.39 mmol) were dissolved in ethanol (20 ml) with heating. When the starting materials were dissolved the solution was allowed to cool to room temperature and a precipitate formed. This precipitate was filtered then washed with ether to provide the intermediate (P) as a white solid (2.85 g, 97%). The intermediate (VI!) (1.89 g, 4.77 mmol) was heated in a solution of sodium hydroxide (0.38 g, 9.54 mmol) in water (20 mL) at 110°C for 2 hours. The solution was allowed to cool to room temperature then acidified with cone. HC1. The resulting precipitate was filtered then washed with water (100 mL) and dried. The crude product was recrystallized from ethanol to produce compound 76 as a white solid (1.4 g, 75%). 'HNMR (DMSO-d6) 5 9.43-9.53 (bs, 2H),8.11-8.16 (m, 1H), 7.47-7.55 (m, 2H), 7.38(d,J=8.1 Hz, 1H), 7.31-7.36 (m, 1H), 6.98 (d, .7=8.1 Hz, 1H),6.71 (s, 1H), 6,17 (s, 1H), 3.98 (s, 3H), 2.17 (q, 7=7.5 Hz, 2H), 0.73 (t, J=7.5 Hz, 3H); ESMS calculated for (C2iHi9N3O3S) 393.1 1; Found 394.1(M+lf. Example 2: Synthesis of Compound 124 3-(2,4-Dihydroxy-phenyl)-4-(naphthaIen-l -yl)-5-mercapto-triazole (505 mg, 1.5 mtnol), which is commercially available from Scientific Exchange, Inc., Center Ossipae, NH 03814, and Et3N (0.84ml, 6.0 mmol) in 15ml CH2CI2 were treated dropwjse with ethyl isocyanate (360mg, 5.0 mmol) at 0°C. The mixture was then warmad to room temperature and stirred for 3h. The reaction mixture was diluted with CHaCb, washed with H:O and saturated brine, dried with NasSO,*, and concentrated in vacua. The residue was chromatographed (Hexane/ EtOAc 3:1) to give Compound 124 as a white solid (480 mg, 58%). 'H-NMR (CDC13) 5 10.13 (s, IH), 7.96 (d, J=9.0 Hz, 2H), 7.61-7.57 (m, 3H), 7.49-7.36(m. 2H), 7.0 l(s, IH), 6.88 (d, J=8.4Hz, IH), 6.70 (d, J=8.4Hz, IH), 4.98-4 .7=7.2 Hz, 3H), 1 . 1 3 (q, 7=1 5.0 Hz, 7=7.2Hz, 6H); ESMS calculated for QnHagNsOsS: 548.18; Found: 549.1 (M+l)+. Example 3; Synthesis of Compound 188 (Figure Removed) 1-Benzenesulfonyl- 7-methoxy-lH-indole (Q) To a solution of 7-methoxyindole (1 eq) in DMF cooled in an ice bath was added NaH (60% d'spersion in oil, 1.2 eq). The reaction was stirred for 1 hr at room temperature then recooled in an ice bath. Benzenesulfonyl chloride (1.1 eq) was added then the reaction was stirred for 2 hrs at room temperature. Water/ethyl acetate were added and the ethyl acetate layer was washed repeatedly (3x) with > water, The ethyl acetate layer was concentrated and evaporated to dryness. l-Bet\zenesulfonyl-7-methoxy-4-nitro-lH-indole (R) To a solution of l-benzenesulfonyl-7-methoxy-lH-indole (Q) (leq) in dichloromethane cooled in an ice bath was added SiOj-HNCh (2 wt eq) in small portions. The reaction was stirred for 1 hrat room temperature. Activated carbon (2 wt eq) was added then the entire mixture was stirred for 1 hr. The mixture was then filtered and evaporated to dryness. Separation of the isomers was achieved by column chromatography. 7-Metttox)>-4-nitro-lH-indole(S) To a solution of l-benzenesulfonyl-7-methoxy-4-nitro-lH-indoie (R) (1 eq) in metjianoi was added a solution of sodium hydoxide (5 eq) in water. The solution was hdated to reflux for 3 his. Methanol was removed under reduced pressure then water and ethyl acetate were added. The ethyl acetate layer separated and washed repeatedly (3x) with water. The ethyl acetate layer was concentrated and evaporated to dryrtess to produce the desired product. l-Isoptopyl~7-methoxy-4-nitro-lH-indole(T) To a solution of 7-methoxy-4-nitro-lH-indoie (S) (1 eq) in DMF cooled in an ice bath was added NaH (60% dispersion in oil, 1.2 eq). The reaction was stirred for 1 hf at room temperature then recooled in an ice bath. 2-Iodopropane (1.1 eq) was added then the reaction was stirred for 2 hrs at room temperature. Water ar.d ethyl acetate were added. The ethyl acetate layer was separated and washed repeatedly (3x) with water. The ethyl acetate layer was concentrated then evaporated to dryness. Further purification by column chromatography produced the pure desired product. 1-Isopnopyl- 7-melhoxy-lH-indo l-4-y famine (U) A solution of l-isopropyl-7-methoxy-4-nitro-lH-indole (T) (leq) and palladium 10% on activated carbon (0.1 wt eq) in methanol/ethyl acetate (1:1) was shaken on a Parr hydrogenation apparatus under hydrogen for 1 hr. The reaction was then filtered through Celite and evaporated to dryness to produce the desirec product. l-Isoprvpyl-4-isothiocyanato- 7-methoxy-lH-indole (V) To a solution of 1 -isopropyl-7-methoxy-lH-indol-4-ylamine (U) (leq) in dichloromethane was added 1,1 '-thiocarbonyldiimidazole (1.2 eq). The reaction was stirred for 2 hrs at room temperature then evaporated to dryness. Further purifiQation by column chromatography produced the pure desired product. 3-(2,4«Dihydroxy-5-ethyl-phenyl)-4-(l-isopropyl-7-methoxy-indol-4-yl)-'Smercapto-[ l,2,4] triazole (Compound 188) 5-Ethyl-2,4-dihydroxy-benzoic acid hydrazide (W) (leq) and l-isopropyl-4- isothiocyanato-7-methoxy-lH-indolc (V) (1.01 eq) were heated in ethanol (0.02 M based on isothiocyante) at 80°C for 1 hr. The solution was allowed to cool to room temperature overnight. The resulting precipitate was filtered, washed with ether, dried and used without further purification (yield 80%). The precipitate was suspended in aqueous NaOH solution (2 eq NaOH) and nitrogen was bubbled through this suspension for 10 min. The reaction was then heated to 110°C for 1 hr under a nitrogen atmosphere then allowed to cool to room temperature. Neutralisation with cone. HC1 produced a white precipiate which was filtered and washed with water. Repeated recrystallisation from EtOH/water produced the desired product (purity >95%, yield 50-70%) 'H-NMR (DMso-d*) 8 (Ppm), 9.52 (s, IH>, 9.42 (s, IH), 7.40 (d, 7=3.3HZ, 1H), 6,82 (d, J=8.4Hz, IH), 6.61 (s, IH), 6.20 (s, IH), 6.05 (d, J=3.3 Hz, IH). 5-30 (qn, > J=7.5Hz, 3H); ESMS CALCULATED. FOR CuHwN^S: 424.16; FOUND: 425.1 (M+l)'. Example 4: Synthesis of Compound 223 (Figure Removed) Compound 223 2,4-Dimethoxy-5-isopropylbenzoic acid (2.24 g, 10.0 mmol, 1.00 equiv.) in 50 mL CH:C12 at rcom temperature was treated with (COCI)2 (1.40 g, 11.0 mmol. 1.10 equiv.) and caialytic amount of DMF (0.1 mL) for 1 hour. Solvent and excess (COCI); were removed in vacuo. The residue was dissolved in 100 mL CHjCh, and treated with 1,3-dimethylo-aminoindole (1.60 g, 10.0 mmol, 1.00 equiv.) and triethy'amine (1.55 g, 15.0 mmol, 1.50 equiv.) at 0°C for one hour. Aqueous workup and removal of solvent gave a light brown solid which was washed with ether tp yield off-white solid (2.28g, 6.22 mmol, 62%). 1HNMR(CDCl3)5(ppm)9.78(brs, IH), 8.21(s, IH), 8.09 (d,J= 2.1 Hz. IH), 7,31 (dd.J=S.7Hzr2.1Hz, IH), 7.22 (d. J=8.7Hz, IH), 6.82 (s, IH), 6.50 (s, IH), 4.09 (s, 3H-. 3.92 (s, 3H), 3.73 (s, 3H). 3.26 (hept, J= 6.9 Hz, IH), 2.32 is. 3H), 1.24(c./=69Hz, 6H). The off-wh;:e solid obtained above was treated with Lawesson's reagent (J.51 g, 3.74 mmo;. 0.6 equiv.) in 50 mL toluene at 110°C for three hours. Toluene was removed on rc:ary evaporator and vacuum pump, and the residue was treated with hydrazine (anhydrous, 3.0 g, 94 mmql, 15.0 equiv.) in 20 mL dioxane at 80°C for 30 minutes. The reaction mixture was extracted with ethyl acetate and water to remove excess hydrazine. The organic layer was dried over MgSO4, and filtered to remove drying agent. Carbodiimidazole (CDI)(3.02 g, 18.7 mmol, 3.00 equiv.) was added to the solution, and the solution was refluxed (65°C) for 2 lours. Solvent was removed, and the residue was treated with 20 mL THF and 10 mL NaOH (2M) to destroy excess GDI. Extraction with ethyl acetate (EtOAc) and water, followed by chrom»tography purification gave the desired product 3-(2,4-methoxy-5-isopropylphenyl()- 4-(l,3-dimethyl-indol-5-yl)-5-hydroxy-[ 1,2,4] triazole as light brown solid (2.20 g, 5.42 mmol, 87%). 'H NMR (CDC13), 6 (ppm) 9.63 (br s, 1H), 7.34 (d, J= 2.1 Hz, 1H), 7.20 (s, 1H), 7.18 (d,y = 8.4 Hz, 1H), 7.00 (dd, /= 8.4 Hz, 2.1 Hz, 1H), 6.80 (s, 1H), 6.19 (s, lH)j, 3.76 (s, 3H), 3.69 (s, 3H), 3.40 (s, 3H), 3.15 (hept, .7=6.9 Hz, 1H), 2.20 (s, 3H), l,10(d,J=6.9Hz,6H). 3-(2,4-methoxy-5-isopropyl-phenyl)-4-(l,3-dimethyl-indol-5-yl)-5-hydroxy- (l,2,4]itriazole obtained above was treated with pyridine hydrochloride (12.53 g, 108.3 nimol, 20.0 equiv.), Nal (0.812 g, 5.42 mmol, 1.0 equiv.) and 0.5 mL water at 205°C under nitrogen protection for 1 hour. The reaction mixture was treated with 200 mL water. The solid was collected by filtration, washed with 3 x 20 mL water, and dissolved in 50 mL 2M NaOH solution. The aqueous solution was extracted with 100 mL EtOAc, and the EtOAc layer was extracted with 2 x 20 mL 0.5M NaOH. EtOAc layer was discarded. The aqueous layer were combined, neutralized with HC1 to PH around 5. and extracted with 3 x 100 mL EtOAc. The combined EtOAc layer was diluted with 50 mL THF, dried over MgSO4, and filtered through silica gfel plug. Most of solvents were removed to form a slurry with around 2 mL of solvent left. Solid was collected by filtration, washed with 2 mL EtOAc, and dried. The desired product 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(l,3-dimethyl-indol-5- yl)-5-hydroxy-[l,2.4] triazole (Compound 223) was obtained as an off-white solid (1.75g, 4.63mmol. 85%). 'H NMR (CD3OD), 6(ppm)7.46(d,J = 1.8 Hz, IH), 7.41 (d, 7= 8.4 Hz, IH), 7.04 (dd, J= 8.4 Hz, 1.8 Hz, IH), 7.02 (s, IH), 6.53 (s, IH), 6.26 (s, IH), 3.74 (s, 3H), 2.88 (sept, J= 6.9 Hz, IH), 2.24 (s, 3H), 0.62 (d, J= 6.9 Hz, 6H); ESMS calculated. forCziH N 378.1; Found: 379.1 (M+ 1)+. The following compounds were prepared as described above in the section entitled "Methods of Making the Compounds of the Invention" and as exemplified in Examples 1 through 4. Example 5: Compound 1 ESMS calcd for CigH,3N3OS: 319.1; Found: 320.0 (M+l)+. Example 6: Compound 2 ESMS calcd for C:iH|9N3O4S: 409.11; Found: 410.0 (M+Hf. Example 7: Compound 5 ESMS calcd for C|9H|5N3O2S: 365.08; Found: 266.0 (M+H)+. Examplje 8; Compound 6 ESMS calcd for C:oH,7N3O2S: 379.10; Found: 380.0 (M+H)*. Examplje 9: Compound 7 ESMS calcd for C:|H]9N302S: 393.11; Found: 394.0 (M+H)*. Examplp 10: Compound 8 ESMS calcd for C;,H19N303S: 393.11; Found: 394.0(M+H)+. Example 11: Compound 9 ESMS calcd for C2]Hi9N302S: 393.11; Found: 394.0 (M+H)+. Example 12: Compound 13 'H-NMR (DMSO-d6) 8 9.65 (s, 1H), 9.57 (s, IH), 7.50 (d, J=8.1Hz, 1H), 7.35 (d, J=3.3Hz, IH), 7.14 (t, .7=7.8 Hz, IH), 6.96 (d, 7=7.5 Hz, IH), 6.88 (d, J=8.1Hz, IH), 6.09-6.11 (m, 2H), 6.01 (dd, y/=2.1 Hz, J2=8.l Hz, IH), 4.13-4.22 (m,2H)»1.36(t,J=7.2Hz,3H); ESMS calcd for QgHieNS: 352.10; Found: 353.1 (M+l)+. Example 13: Compound 14 'H NMR (DMSO-d6) 5 9.72(s, IH), 9.67(s, IH), 7.04-7.0 l(m, IH), 6.83- 6.78(m, 2H), 6.66-6.63(m, 1 H), 6.20-6. 1 9(m, 2H), 4.22(s, 4H); ESMS calcd for C|6Hi3N3O4S: 343.06; Found: 344.0 (M+l)*. Example 14; Compound 15 ESMS calcd for QsHuNjC^S: 299.07; Found: 300.0 (M+H)+. Example IS; Compound 16 ESMS calcd for CisHu^OzS: 299.07; Found: 300.0 (M+H)+. Example 16; Compound 17 ESMS calcd for C14H|0C1N302S: 319.02; Found: 320.0 (M+H)+. Exampfe 17; Compound 18 ESMS calcd for C|4HioClN3O2S: 3 19.02; Found: 320.0 (M+H)+. Examplje 18; Compound 19 ESMS calcd for C,4H,oClN3O2S: 319.02; Found: 320.1 (M+H)+. Examplje 19; Compound 20 ESMS calcd for Ci sH^CbS: 3 1 5.07; Found: 3 1 6.0 (M+H)+. Example 20: Compound 21 ESMS calcd for C|SH|3N3O.-}S: 315.07; Found: 316.0 (M+H)+. Exam nip 21: Compound 22 ESMS calcd forCisHuNjOsS: 315.07; Found: 316.0 (M+H)+. Exam pip 22; Compound 23 ESMS calcd forCi4Hi0FN3O2S: 303.05; Found: 304.0 (M+H)+. Exam pip 23; Compound 23 'H NMR (DMSO-d6) 8 9.69 (s, lH),9.65(s, 1H), 7.16(d,7=7.2Hz, 1H), 7.05(t,J=7.2Hz, lH),6.93(d,J=8.1Hz,2H),6.11-6.16(m,2H),2.21 (s, 3H), 1.89 (s, 3H); ESMS Calcd C16H,sN3O2S: 313.09, Found 3 14.1 (M+l)+. Example 24; Compound 24 ESMS calcd for C^H^C^S: 313.09; Found: 314.0 (M+H)+. Examplje 25; Compound 25 'H NMR (DMSO-d6) 6 10.44 (m, 1H), 8.00-7.95 (m, 2H), 7.55-7.37 (m, 5H), 6.6 1 (d, J = 7.8 and 1 .8 Hz, 1 H), 6.5 1 (t, J = 8.6 Hz, 1 H), 6.4 1 (d, J = 1 0.8 Hz, 1 H): ESMS calcd forC|gH|2FN3OS: 337.07; Found: 338.0 (M+l)+. Example 26: Compound 26 'H NMR (DMSO-d6) 8 9.57 (s, 1H), 7.99 (d, J = 8.4 Hz, 1H), 7.96 (d, J = 6.9 Hz, 1H), 7.55-7.37 (m, 5H), 6.61 (d,y=8.1 Hz, 1H), 5.83 (d, 7=2.1 Hz, 1H), 5.73(dd, V- 8.1 and 1.8 Hz, 1H), 5.24 (s, 2H); ESMS calcd for C,8Hi4N4OS: 334.09; Found: 335.0 (M+l)+. Example 27: Compound 27 ESMS calcd for CigH^NsC^S: 341.12; Found: 342.0 (M+H)+. Example 28; Compound 28 ESMS calcd forC16H,5N;,02S: 313.09; Found: 314.0 (M+H)*. Exampje 29: Compound 29 ESMS calcd for CuH^CbS: 313.09; Found: 314.0 (M+H)+. Example 30: Compound 30 ESMS calcd forC^His^ChS: 313.09; Found: 314.0 (M+H)+. Exam pile 31: Compound 31 ESMS calcd for Ci4Hi0FN3O2S: 303.05; Found: 304.0 (M+Hf . Example 32: Compound 32 ESMS calcd for Ci5H|3N3O2S: 33 1 .04; Found: 332.0 (M+H)+. Examp|e 33: Compound 33 ESMS calcd for C!gHi3N3O2S: 335.07; Found: 336.0 (M+Hf. Example 34: Compound 34 ESMS calcd for CieHisNsOjS: 313.09; Found: 314.0 (M+H)+. Example 35: Compound 35 ESMS calcd for C;5Hi2FN3O2S: 317.06: Found: 317.0 (M+H)+. Exampje 36: Compound 36 ESMS calcd for C20H15N3O2S: 361.1; Found: 362.0 (M+l)*. Examnje 37: Compound 37 !H NMR (DMSO-d6) 8 10.03 (s, IH), 8.00-7.96 (m, 2H), 7.55-7.37 (m, 5H), 7.00 (d,J= 8.1 Hz, IH), 6.20 (m, 2H), 3.57 (s, 3H); ESMS calcd for C,9H|5N3O2S: 349.09; Found: 350.0 (M+l)*. Example 38: Compound 38 ESMS calcd for Ci4H9CI2N302S: 352.98; Found: 353.9 (M+H)+. Example 39: Compound 39 !H NMR (DMSO-dfi) 6 9.74 (s, 1H), 9.63 (s, 1H), 8.14 (m, 1H), 7.52-7.48 (m, 2H), 7.37 (d, J= 8.4 Hz, 1H), 7.32 (m, 1H), 6.96 (d, = 8.1 Hz, IK), 6.90 (d, = 8.4 Hz, 1H). 6.08 (d. = 1.9 Hz, 1H), 6.01 (d, = 8.4 Hz, 1H), 3.98 (s, 3H); ESMS calcd for Ci9H|5N303S: 365.08; Found: 366.0 (M-l)+. Example 40: Compound 40 ESMS calcd for C2sH|6N3O2S: 409.09; Found: 410.0 (M-rl)T. Example 41: Compound 42 'H NMR (DMSO-de) 6 9.75(s, 1H), 9.67- s, II!), 7.08(s, 2H), 6.96-6.94(m, 2H), 6,18-6.13(m, 2H), 2.72-2.50(m, 3H), 2.35-2.28(m, 1H), 1.64-1.60(m, 4H); ESMS calcd for Qg HiTNjOaS: 339.10; Found: 340.0 (M^l)+. Example 42: Compound 43 ESMS calcd for C22HisN3O2S: 385.09; Found: 386.0 (M-l)+ Example 43: Compound 44 ESMS calcd for C2oH,5N302S: 361.09; Found: 362.0 (M-lf Example 44: Compound 45 ESMS calcd for C,9H|5N302S: 349.09: Found: 350.0 (M+l)~ Example 45: Compound 46 ESMS calcd for C,9H:iN3O3S: 371.13; Found: 372.0 (M-1)T Example 46: Compound 47 ESMS calcd for C2:H:7N303S: 413.18; Found: 414.1 (M-H)* Example 47: Compound 48 ESMS caicd for CigH^ClNsOjS: 369.03: Found: 370.0 (M+H)+. Example 48: Compound 49 'H NMR (DMSO-d6) 8 9.49 (s, 1H), 9.40 (s, 1H), 7.94-7.99 (m, 2H), 7.38- 7.56 (in, 5H), 6.70 (s, 1H), 6.13 (s, 1H), 2.12 (q. J=7.2 Hz, 2H), 0.71 (t, J=7.2Hz, 3H); ESMS Caicd for Q-oHntyChS: 363.10, Found 364.1(M+1)*. Example 49: Compound 50 ESMS caicd fo^oH^OsS: 409.07; Found: 410.0 (M+H)+. Example SO: Compound 51 ESMS caicd for QgHi^OzS: 350.08; Found: 35 1 .0 (M+H)+. Example 51: Compound 52 ESMS caicd for Ci7H|2N4OS: 320.07; Found: 320.9 (M+H)*. Example 52: Compound 53 'H NMR (CDCI3) 5 12.0 (br s, 1H), 9.87 rbr s, 1H), 9.83 (br s, 1H), 7.97 (d, J = 8.1 Hz,2H), 7.41 -7.56 (m, 5H),7.13(d, J= 1.5 Hz, 1H), 7.07 (d,J= 8.7 Hz, 1H), 6.71 (dd, /= 1.8 Hz. 8.1 Hz, 1H), 1.93 (s, 3H); ESMS caicd for C^nN^S: 376.1; Found: 377.0(M+lf. Exam pile 53: Compound 56 ESMS caicd forC16Hi5N3O4S: 345.08; Found: 346.0 (M+l)+. Example 54: Compound 57 ESMS caicd for CuHi^OjS: 352.10; Found: 353.0 (M+l)*. Example 55: Compound 61 'H NMR (DMSO-d*) 6 9.66(s, 1 H), 9.60(s, IH), 7.29-7.27(m, IH), 7.12-7- 10(m.2H),7.03-7.00(m, IH), 6.19-6.17(m, 2H), 1.18(s, 18H); ESMS calcd for Ci^NsC^S: 397.18; Found: 398.1 (M+l)+. Example 56: Compound 64 ESMS calcd for QiH : 389.08; Found: 390.0 (M+H)*. Example 57: Compound 65 ESMS calcd for : 379.06; Found: 380.0 (M+l)+ Example 58: Compound 66 ESMS calcd for 406.1 1; Found: 407.0 (M+l)+. 59: Compound 67 ESMS calcd for 393.1 1 ; Found: 394.0 (M+l)*. Example 60: Compound 68 ESMS calcd for CnH : 393.1 1; Found: 394.0 (M+l)*. Example 61: Compound 69 ESMS calcd for C:,H19N303S: 393.1 1; Found: 394.0 (M+l)+. Example 62: Compound 70 ESMS calcd for C S: 336.07; Found: 337.0 (M+H)+ Example 63: Compound 71 ESMS calcd for QnH : 393.1 1; Found: 394.0 (M+l)+. Example 64: Compound 72 'H NMR (DMSO-d*) 5 10.3 (br s, IH), 7.95-8.19 (m, 2H), 7.48-7.72 (m, 5H), 7.17 (d, J= 8.4 Hz, IH), 6.44 (d, J- 8.4 Hz, IH), 5.95 (d, J= 2.1 Hz, IH), 5.73 (dd.J«2.1 Hz, 8.4 Hz, 1 H), 5.47 (br s, IH), 3.62 (s, 3H); ESMS calcd for C^H./N^S;: 412.1; Found: 413.0(M-H)+. Example 65: Compound 73 'H NMR (DMSO-dg) 8 9.37 (s, IH), 8.94 (s, IH), 7.94-7.98 (m, 2H), 7.43- 7.60 (m, 5H), 5.97 (s, IH), 1.85 (s, 3H), 1.81 (s, 3H); ESMS calcd for C2oHi8N3O2S: 363.1 ; Found: 364.0(M+1)*. Example 66; Compound 74 ESMS calcd for QiH^N^S: 409.1 1 ; Found: 4 10.0 (M+H)*. Example 67; Compound 75 'H NMR (DMSO-d6) 8 9.46 (s, IH), 9.45 (s, IH), 7.95-8.00 (m, 2H), 7.38- 7.56 (m, 5H), 6.65 (s, IH), 6.15 (s, IH), 2.07-2.14 (m, 2H), 081-1.18 (m, 1 IH): ESMS calcd for C24H26N302S: 419.1; Found: 420.1(M+1)*. Example 68; Compound 76 ESMS calcd for CaiH^N^OjS: 393.1 1 ; Found: 394.0 (M+H)+. Example 69; Compound 77 ESMS calcd for C:iHi9N303S: 393.1 1 ; Found: 394.0 (M+H)+. E^anjple 70; Compound 78 'H NMR (DMSO-d6) 8 9.71 (s, IH), 9.35 (s, IH), 7.98-8.04 (m, 2H), 7.50- 7.62 (|m, 5H), 6.58 (s, IH), 2.15 (q, J= 7.5 Hz, 2H), 0.58 (t, J= 7.5 Hz, 3H); ESMS calcd for CsoHnClNsChS: 397.0; Found: 398.0(M+1)+. Example 71: Compound 79 ESMS calcd for Ci9H2iN303S: 371.13; Found: 372.0 (M+H)+. Example 72: Compound 80 ESMS calcd for C2iHi9N302S: 393.1 1; Found: 394.0 (M+H)*. Example 73: Compound 81 ESMS caicd for C-MHnNjOjS: 379.10; Found: 380.0 (M+H)+ Example 74: Compound 82 ESMS calcd for C:iHi9N302S: 393.11; Found: 394.0 (M+H)+. Example 75: Compound 83 ESMS calcd for C2oHi7N303S: 379.10; Found: 380.0 (M+H)+. Example 76: Compound 84 ESMS calcd for C2oHi7N303S: 379.10; Found: 380.0 (M+H)+. Example 77; Compound 85 ESMS calcd for Ci9Hi5N302S: 365.08: Found: 266.0 (M+H)+. • Example 78: Compound 86 'H NMR (DMSO-d6) 6 9.68 (s, 1H), 9.58 (s, 1H), 8.2 (dd, J= 7.0 and 2.4 Hz, 1H), 7.50 (m, :H), 7.40 (tr, J = 8.1 Hz, 1H), 7.32 (m, 1H), 6.97 (d, J= 7.5 Hz. 1H), 6,95 (m, 1H), 6.89 (d, = 8.4 Hz, 1H), 6.08 (d, = 2.1 Hz, 1H), 6.0 (dd, = 7.4 and 2.1HZ, lH),3.96(s,3H); ESMS calcd for Ci9H,5N303S: 365.08: Found: 366.0 (M+l)+. Example 79: Compound 87 'H NMR (MeOH-d-t) 8 8.25 (m, 1H), 7.96 (s, 1H), 7.46-7.44 (m, 2H), 7.26 (d,/=8.4Hz, 1HX6.83 (d,7=8.1H7, 1H), 6.70 (d?J= 8.7 Hz, 1H), 6.17(d, J = 2.1 Hz, 1H), 5.98 (dd, J= 8.4 and 2.4 Hz, 1H); ESMS calcd forC,gH,3N303S: 351.07: Found: 352.0 (M+lf. Example 80: Compound 88 'H-NMR (DMSO-de) 5 9.69 (s, 1H). 9.59 (s, 1H), 7.54 (d, J=8.1Hz, 1H), 7.46 (d, J-3Hz, 1H), 7.14 (t, J=7.8 Hz, 1H), 6.97 (d, J=7.2 Hz, 1H), 6.89 (d, J=8.7Hz, 1H), 6.12-6. J .3 (m, 2H), 6.02 (dd, J,=2.4 Hz, J:=8.4 Hz, 1H), 4.74 (qn, J=6.6Hz, 1H), 1.40-1.46 (m, 6H); ESMS calcd for Ci9H,gN402S: 366.12; Found: 367.1 (M+l)+. Example 81: Compound 89 ESMS calcd for CsHjjNjOjS: 391.14; Found: 392.0 (M+H)+. Example 82: Compound 90 'H NMR (DMSO-d6) 6 9.47 (s, 1H), 9.43 (s, 1H), 7.94-8.00 (m, 2H), 7.39- 7.57 (m, 5H), 6.68 (s, 1H), 6.15 (s, 1H), 2.05-2.15 (m, 2H), 1.05-1.17 (m, 2H), 0.50 (t, y- 7.5 Hz, 3H); ESMS calcd forCziHaMbaS: 377.1; Found: 378.0(M+1)". Example 83: Compound 91 'H NMR (DMSO-d«) 59.15 (s, 1H), 8.50 (s, 1H), 8.00 - 8.07 (m, 2H), 7.47- 7.63 (ft, 5H), 6.27 (s, 1H), 2.06 (q, J= 7.5 Hz, 2H), 1.93 (s, 3H), 0.45 (t, J= 7.5 Hz, 3H); ESMS calcd for C21H2oN302S: 377.1; Found: 378.0(M+1)+. Example 84; Compound 93 ESMS calcd for Ci6Hi5N304S: 345.08; Found: 346.0 (M+H)+. Example 85: Compound 95 ESMS calcd for C^HisN^S: 324.07; Found: 325.0 (M+H)~. Example 86; Compound 96 ESMS calcd for C19H|8N403S: 382.11; Found: 383.0 (M+H)T. Example 87: Compound 98 ESMS calcd for CnH^N^S: 336.07; Found: 337.0 (M+H)* Example 88; Compound 99 ESMS calcd for Ci9Hi3N304S: 379.06; Found: 379.9 (M+H)T Example 89: Compound 100 'H-NMR (DMSO-ck) 69.52 (s, 1H), 9.42 (s, 1H), 7.56 (d, J=8.7Hz, IK), 7.49 (d, J=33Hz, !H), 7.14 (t, J=7.5 Hz, 1H), 6.95 (d, J=8.4Hz, 1H), 6.61 (s, 1H), 6.21 (s, 1H), 6.14 (dd, J=3.3Hz, 1H), 4.76 (qn, J=6.6Hz, 1H), 2.14 (q, J=7.5Hz, 2H), 1.4 1-1.47 (m.6H), 0.66 (t,y=7.5Hz,3H); ESMS calcd for C.iH^N^S: 394.15; Found: 395.1 (M+lf. Example 90: Compound 101 ESMS calcd for C^HnNsOsS: 395.1 1; Found: 396.0 (M^H)*. Example 91: Compound 102 ESMS calcd. for C^HsoNsChS: 381.1; Found: 382.0 (M + if. Example 92: Compound 103 !H NMR (DMSO-cU) 5 9.48 (s, 1H), 9.38 (s, 1H), 7.29(d, J= 8.4 Hz,' 1H), 7.25(d,J= 1.8 Hz. 1H), 6.85-6.89 (m,2H), 6.18 (s, 1^,3.61(5,3^0,2.30(5. 3H), 2.29 (q, J= 7.5 Hz. 2H), 2.09 (s, 3H), 0.94 (t, J= 7.5 Hz, 3H); ESMS calcd for CjiHTsN^S: 394.1; Found: 395.0(M+1)+. Exam|ple 93: Compound 104 ESMS calcd for C^H^CbS: 365.08; Found: 366.0 (M+H)+. Exanjple 94: Compound 106 ESMS calcd for C^HpN^S: 377.1; Found: 378.0(M+H)+. Example 95: Compound 107 ESM3 calcd for QgHnCl^CKS: 369.0; Found: 370.0(M+H)+. Example 96: Compound 116 'H NMR (DMSO-d 8.1 and 1.8 Hz, 1H), 6.29 (m, 1H), 3.65 (s, 3H), 3.16 (s, 3H); ESMS calcd for C2oH,7N3O:S: 363.10; Found: 364.0 (M+l)+. Example 97: Compound 117 'H-NMR (CDC13) 5 7.83(d, J-S.l Hz, 2H), 7.48-7.34(m, 4H), 7.28-7.20(m, 1H), 6.99 (d, J=1.8Hz, 1H), 6.80(d, ^=8.7Hz, 1H), 6.62-6.58(m, 1H), 2.94(s, 3H), 2.S9(s, 3H), 2.84(s, 3H), 2.8 l(s, 3H), 2.75-2.69(m, 6H); ESMS calcd for C27H:gN6O5S: 548.18; Found: 549.2 (M+l)*. Example 98: Compound 122 'H-NMR (CDC13) 5 7.98(m, 2H), 7.60-7.55(m, 3H), 7.51-7.45(m, 1H), 7.36- 7.33(m, lH),6.98-6.97(m, 1H), 6.86(d, J=9.9Hz, 1H), 6.70-6.67(m, lH),2.86(s. 3H),2,26(s.3H),2.21(s,3H); ESMS calcd for C.aH^NsOsS: 461 .10; Found: 462.0 (M+l)+. Example 99; Compound 125 ESMS calcd for C2oHnN3O3S: 379.10; Found: 380.0 (M+H)+. Example 100: Compound 126 ESMS calcd for Ci0HnN3O:S: 237 06; Found: 238.0 (M+H)+. Example 101: Compound 127 ESMS calcd for C,,Hi;,N3O:S: 251.07; Found: 252.0 (M+H)*. Example 102: Compound 128 ESMS calcd for Ci,H!3N30:S: 251.07; Found: 252.0 (M+H)+. Examjpie 103: Compound 129 ESMS calcd for Ci,H,|N30:S: Z-9.06; Found: 250.0 (M^H)+. Example 104: Compound 130 ESMS calcd for Ci2H,;N30:S: 265.09; Found: 266.0 (M+Hf. Example 105: Compound 131 ESMS calcd for C2oHi5N3O4S: 393.08; Found: 394.1 (M+H)+. Example 106: Compound 177 'H NMR (DMSO-cU) 6 9.34(s, 1H), 9.22 is, 1H), 8.01-7.96 (m, 2H), 7.58- 7.44 (m, 5H), 6.56 (s, 1H), 6.14 (s, 1H), 3.29 (s, 3H); ' ESMS calcd for Ci9Hi5N3O3S: 365.08; Found: 366.0(M+lf . Example 107: Compound 178 'H NMR (DMSO-cio) 8 10.29 (s, 1H), 9.49 (s,lH), 9.42 (s, 1H), 8.1 .J = 5.1 Hi, 1H), 7.45-7.43 (m,2H), 7.26 (t,J= 8.0 Hz, 1H), 6.84 (d, J- 7.8 Hz, iff). 6.75 (d, J= 8.7 Hz, 1H), 6.66 (s, 1H), 6.14 (s, 1H), 2.12 (q, J- 7.5 Hz, 2H), 0.70 (t. J=7.2Hz,3H); ESMS calcd for C2oHi7N3O3S: 379.10; Found: 379.9 (M+l)*. Example 108; Compound 179 ESMS calcd for dgH O.S: 349.09; Found: 350.0 (M+l)+. Example 109: Compound 180 ESMS calcd for CH OaS: 349.09; Found: 350.0 (M+H)*. 110: Compound 181 ESMS calcd for C20H15N3O2S: 361.09; Found: 362.0 (M+H)~ Example 111: Compound 182 ESMS calcd for C,6H|5 N303S: 329.08: Found: 330.0 (M+H)+. Examjple 112: Compound 183 ESMS calcd for C20Hi7N3O:S: 363.10; Found: 364.0 (M+H)+. Example 113: Compound 184 ESMS calcd for C18H,3N3O3S: 350.38; Found: 351.9(M+H)*. Example 114: Compound 185 ESMS calco. for CroH.^OrS: 380.1; Found: 381.0 (M + I f . Example 115: Compound 187 ESMS calcd. forC^eNV^S: 381.1: Found: 382.0 (M + 1)*. Example 116: Compound 190 ESMS CALCD. FOR QjHijN^S: 394.15: FOUND: 395.0 (M-l)~. Example 117: Compound 191 ESMS cakd. for C;:H;A',0,S: 438.1: Found: 439.0 (M + 1)*. Example 118: Compound 192 ESMS calcd. forQoH^NfOzS: 395.1: Found: 396.0 (M + If. Exarnple 119: Compound 193 ESMS calcd. for C;oH;;N:-0:S: 395.1: Found: 396.0 (M -f- 1)". Example 120: Compound 194 ESMS calcd. for C;3HrN,0:S: '-::.!: Found: 423.0 (M ^ 1)'. Example 121; Compound 195 ESMS caicd. for C:3H:,-N,0:S: 420. '.: Found: -21.0 (M - I f . Exatpple 122: Compound 196 ESMS cai;d. for C:5H;;N,0;S: -S.l: Found: 449.3 i.M - I f . Example 123: Compound 19" ESMS caUd. for C::H;,N,0;S: -'S.I 5; Found: 409.2 ,M-1)'. Example 124: Compound 198 ESMS calcd. for C:3H:6N4O2S: 422.18; Found: 423.3 (M+1)*. Example 125: Compound 199 ESMS caicd. for C24H;8N4O2S: 436.19; Found: 437.3 (M+1)*. Example 126; Compound 200 ESMS calcd. for C22H:2N4O2S: .406.15; Found: 407.2 (M+1)* Example 127; Compound 201 ESMS . ..wd. for C23H24N4O3S: 436.16; Found: 437.3 (M+1)*. Example 128: Compound 202 ESMS calcd. for C22H:3N4O2S: 406.1; Found: 407.0 (M + H)* Example 129: Compound 204 ESMS calcd. for C24H:gN4O3S: .452.19; Found: 453.2 (M+1)* Example 130; Compound 205 ESMS calcd. for C23H ^OsS : 436.16; Found: 437.1 (M+1)*. Example 131: Compound 206 ESMS calcd. forC2!H23N4O2S: 394.1; Found: 395.1 (M+1)* Example 132: Compound 207 ESMS calcd. forC20H:iN4O2S: 380.1; Found: 381.1 (M+1)* Example 133: Compound 208 ESMS calcd. for CzsH^OsS: 438.17; Found: 439.1 (M+1)' Example 134: Compound 209 ESMS calcd. for C22H24N4O2S: 408.1 ; Found: 409.1 (M + 1)* Example 135: Compound 210 ESMS calcd. for CaJiaN^S: 430.1; Found: 43 1.1 (M + 1)+. Example 136; Compound 211 ESMS calcd. forCaiH^QsS: 410.14; Found: 411.1 (M+lf . Example 137: Compound 212 ESMS calcd. for C^H^OaS: 438.17; Found: 439.1 (M+l)+. Example 138: Compound 213 ESMS calcd. forCjoHaMOjS : 380.1; Found: 381.1 (M + if. Example 139: Compound 214 ESMS oalcd. for C|9H,9N4O2S: 366.1; Found: 367.1 (M + 1)+. Example 140; Compound 215 ESMS calcd. for CjoH^NjC^S: 397.1; Found: 398.1 (M+lf. Example 141: Compound 216 'H NMR (DMSO-dfi): 6 (ppm) 9.56 (s, 1H), 9.40 (s, 1H), 8.03 (d, J= 2.4 Hz, 1H), 7.58 (d, ,7=8.4 Hz, 1H), 7.54 (d,7= 2.1 Hz, 1H),7.11 (dd, J= 8.4,2.1 Hz, 1H), 6.97 (d,J= 2.4 Hz, 1H), 6.89 (s, 1H), 6.17 (s, 1H), 2.23 (q,J= 7.2 Hz, 2H), 0.93(^J=7.2Hz, 3H); ESMScaicd. for C,gH,5N3O3S: 353.08; Found: 354.0 (M+l)+. Example 142: Compound 217 'H NMR (DMSO-d6): 5 (ppm) 9.59 (s, 1H), 9.43 (s, 1H), 7.67 (d, J= 8.7 Hz, 1H), 7.54 (d,y= 2.1 Hz, 1H), 7.20 (dd,y= 8.4, 2.1 Hz, 1H), 6.96 (s, 1H), 6.18(5. 1H), 2.60 (s, 3H), 2.34 (q, y = 7.2 Hz, 2H), 0.98 (t, J= 7.2 Hz, 3H); ESMS calcd. for dgH^N^S: 368.09; Found: 369.0 (M+lf. Example 143: Compound 218 , ESMS calcd. for C2|H23N402S: 394.1; Found: 395.1 (M + 1)+. Example 144: Compound 219 ESMS calcd. for C2,H21N4O2S: 392.1; Found: 393.1 (M + 1)+. Example 145; Compound 220 ESMS calcd. for C2oH2,N4O3: 364.1; Found: 365.1 (M + 1)+. Exam pile 146: Compound 221 ESMS calcd. forC20H2,N402S: 379.1; Found: 381.1 (M+ 1)+. Example 147: Compound 222 ESMS calcd. for C21H23N4O2S: 394.1; Found: 395.1(M + 1)*. Exam pile 148: Compound 224 ESMS calcd. forC19H2,N4O2S: 368.1; Found: 369.1 (M + 1)+. Exam pile 149: Compound 225 ESMS calcd. for C,9H|9N4O2S: 366.1; Found: 367.1(M + 1)*. Example 150: Compound 226 ESMS calcd. for C20H2iN4O3: 364.1; Found: 365.1 (M + 1)*. Example 151: Compound 227 ESMS calcd. for C2!H22N4O2S: 394.15; Found: 395.1 (M+l)+. Example 152: Compound 228 ESMS calcd forC22H24N4O2S: 408.16; Found: 409.1 (M+l)+. Example 153: Compound 229 ESMS calcd. for C20H,gF3N5O2S: 449.11; Found: 450.1 (M+l)+. Example 154: Compound 230 ESMS calcd. for Ci9H|9N5O2S: 381.13; Found: 382.1 (M+1 )+ Examjple 155; Compound 231 ESMS calcd. forC^HuNsOjS: 381.13; Found: 382.1 (M+l)+. Examjple 156; Compound 232 ESMS calcd. forCz-^N^S: 392.18; Found: 393.1 (M+l)+. Example 157: Compound 233 ESMS calcd. for C 1 8H 1 7N3O4S: 371 .09; Found: 372. 1 (M+1 )+. Example 158: Compound 234 ESMS calcd. for C20H21N3O2S: 367.14; Found: 368.1 (M+l)+. Example 159; Compound 235 ESMS calcd. for Ci9Hi9N5O2S: 381.13; Found: 382.1 (M+l)+. Example 160; Compound 239 ESMS clcd for C,9H2iN4O2S: 368. 1 ; Found: 369. 1 (M + H)*. Example 161: Compound 240 ESMS cicd for C,gH|6N4O3S: 368.09.10; Found: 369.1 (M+H)*. Example 162: Compound 241 ESMS clcd forCnHisNsCbS: 369.09; Found: 370.1 (M+Fff. Example 163: Compound 242 ESMS clcd for CI9H,8N4O3S: 382.11; Found: 383.1 (M+Hf. Example 164: Compound 243 ESMS clcd for C22H26N4O3S: 426.17; Found: 427.1 (M+H)+. Exam pile 165: Compound 244 ESMS clcd forC|8Hi6N4O4S: 384.09; Found: 385.1 (M+H)* Example 166: Compound 245 ESMS clcd for CuH^C^: 400.07; Found: 401.1 (M+H)* Examnjle 167: Compound 245 ESMS clcd for C^H^C^: 386.05; Found: 387.0 (M+H)+. Example 168: Inhibition of Hsp90 Hsp90 protein was obtained from Stressgen (Cat#SPP-770). Assay buffer: 100 mM Tris-HCl. Ph7.4, 20 mM KCI, 6 mM MgCl2. Malachite green (0.0812% w/v) (M9636) and polyviny alcohol USP (2.32% w/v) (PI 097) were obtained from Sigma. A Malachite Green Assay (see Methods Mol Med, 2003, 85:149 for method details) was used for examination of ATPase activity of Hsp90 protein. Briefly, Hsp90 protein in assay buffer (100 mM Tris-HCl, Ph7.4, 20 mM KCI, 6 mM MgCI2) was mixed with ATP alone (negative control) or in the presence of Geldanamycin (a positive control) or Compound 108 in a 96-well plate. Malachite green reagent was added to the reaction. The mixtures were incubated at 37°C for 4 hours and sodium citrate buffer (34% w. v sodium citrate) was added to the reaction. The plate was read by an ELISA reader With an absorbance at 620 nm. As can be seen in Figure 1, 40 uM of geldanamycin, a natural product known to inhibit Hsp90 activity, the ATPase activity of Hsp90 was only slightly higher than background. 40 ^M Compound 108 showed an even greater inhibition of ATPase activity of Hsp90 than geldanamycin, and even at 4u.M Compound 108 showed significant inhibition of ATPase activity of Hsp90 protein. Example 169: Degradation of Hsp90 Client Proteins via Inhibition of Hsp90 Activity A. Cells and Cell Culture Human high-Her2 breast carcinoma BT'474 (HTB-20), SK-BR-3 (HTB-30) and MCF-7 breast carcinoma (HTB-22) from American Type Culture Collection, VA, USA were grown in Dulbecco's modified Eagle's medium with 4 mM Lglutamine and antibiotics (lOOIU/ml penicillin and 100 ug/ml strept0mycine;GibcoBRL). To obtain exponential cell growth, cells were trypsinized, counted and seeded at a cell density of 0.5x106 cells /ml regularly, every 3 days. All experiments were performed on day 1 after cell passage. B. Degradation of Her2 in Cells after Treatment with a Compound of the Invention BT-474 cells were treated with O.SfaM, 2uM, or 5uM of 17AAG (a positive control) or O.SjiM, 2|xM, or 5uM of Compound 108 or Compound 49 overnight in DMEM medium. After treatment, each cytoplasmic sample was prepared from IxlO6 cells by incubation of cell lysis buffer (#9803, cell Signaling Technology) on ice for 10 minutes. The resulting supernatant used as the cytosol fractions were % dissolved with sample buffer for SDS-PAGE and run on a SDS-PAGE gel, blotted onto a nitrocellulose membrane by using semi-dry transfer. Non-specific binding to nitrocellulose was blocked with 5% skim milk in TBS with 0.5% Tween at room temperature for 1 hour, then probed with anti-Her2/ErB2 mAb (rabbit IgG, #2242, Cell Signaling) and anti-Tubulin(T9026, Sigma) as housekeeping control protein. HRP-Conjugated goat anti-rabbit IgG (H+L) and HRP-conjugated horse anti-mouse IgG (H+L) were used as secondary Ab (#7074, #7076, Cell Signaling) and LumiGLO reagent, 20x Peroxide (#7003, Cell Signaling) was used for visualization. As can be seen from Figure 2, Her2, an Hsp90 client protein, is almost completely degraded when cells are treated with 5|aM of Compound 108 and partially degradated when cells are treated with 2^M and 0.5uM of Compound 108. Compound 49 which is even,more active than Compound 108 causes complete degradation of Her2 when cells are treated with 2pM and 5|oM and causes partial degradated when cells are treated with 0.5uM 17AAG is a known Hsp90 inhibitor and is used as a positive control. C. Fluorescent Staining of \isr2 on the Surface of Cells Treated _with a Compound of the Invention After treatment with a compound of the invention, cells were washed twice with IxPBS/r/oFBS, and then stained with anti-Her2- FITC (#340553, BD) for 50 min at 4°C. Cells were then washed three times in FACS buffer before the fixation in 0,5 ml 1% paraformadehydrede. Data was acquired on a FACSCalibur system. Isotype-matched controls were used to establish the non-specific staining of samples and to set the fluorescent markers. A total 10,000 events were recorded from each sample. Data were analysed by using CellQuest software (BD Biosciances). The ICso range for Hsp90 inhibition by compounds of the invention are Used below in Table 2. Table 2: ICso range of compounds of the invention for inhibition of Hsp90 ICso Range 3uM 3nMto lOfoM Compound Number 8, 13, 39, 49, 63, 76, 77, 79, 87, 88, 95, 96, 100, 103. 177, 178, 185, 188. 189, 195, 197, 198, 201, 202, 203, 204, 205, 206, 207, 208, 209, 21 1, 212, 213, 214, 215, 216,218,219,220,221,222,223 2. 5, 6, 7, 9, 14, 27. 28, 34, 36, 38, 42, 48, 64, 70, 93. 97, 108, 122, 183, 184, 194, 196, 217 lOuM to lOOuiM j 21, 22, 30, 51, 59, 60, 61, 62, 94, 98, 99, 102, 104. 123, I 181, 182, 186, 187, 191, 192, 193, 199,210 D. Apoptosis analysis After treatment with the compounds of the invention, cells were washed once with lxPBS/l°orBS, and then stained in binding buffer with FITC-conjugated Annexin V and ?ropidium iodide (PI) (all obtained from BD Biosciences) for 30 min at 4°C. Flc'.*. cytometric analyses was performed with FACSCalibur (BD Biosciences) and a total 10,000 events were recorded from each sample. Data vs ere analyzed by using CellQuest software (BD Biosciences). The relative fluorescence was calculated after subtraction of the fluorescence of control. E- Degradation of c-Kit in Cells after Treatment with a Compound_of the Invention Two leukemia cell lines, HEL92.1.7 and Kasumi-1, were used for testing ckit degradation induced by Hsp90 inhibitors of the invention. The cells (3X10s per well) were treated with 17AAG (0.5 mM), Compound 188 or Compound 221 for about 18 h (see Figs. 3 and 4 for concentrations). The cells were collected and centrifuged (SORVALL RT 6000D) at 1200 rpm for 5 min. The supematants were discarded, and the cells were washed one time with IX PBS. After centrifugation the cells were stained with FITC conjugated c-kit antibody (MBL International, Cat# KOI05-4) in 100 ml IX PBS at 4°C for 1 h. The samples were read and analysized with FACSCalibur flow cytometer (Becton Dicknson). c-Kit, a tyrosine kinase receptor and one of the Hsp90 client proteins, was selected and used in a FACS-based degradation assay. The results of the assay showed that Compound 188 and Compound 221, induced c-kit ^gradation at 0.5 and 0.05 nM in a dose-dependent manner. Surprisingly, 17-AAG, which is a potent Hsp90 inhibitor and is in phase 2 clinical trials, could not induce c-kit degradation at 0.5 pM in two leukemia cell lines, HEL92.1.7 (see Fig. 3) and Kasumi-1 (see Fig. 4). Since the compounds of the invention cause c-kit degradation more efficiently than other Hsp90 inhibitors, the compounds of the invention are expected to be more effective in the treatment of c-kit associated tumors, such as leukemias, mast cell tumors, small cell lung cancer, testicular cancer, some cancers of the gastrointestinal tract (including GIST), and some central nervous system. The results of the FACS analysis were confirmed with Western blot analysis (see Fig. 5). In Kasumi-1 cells (myelogenous leukemia), Compound 221 (100 nM and 400 nM) induced the degradation of c-Kit. In contrast, 17-AAG had no effect of c-Kit protein levels. F. Degradation of c-Met in Cells after Treatment with a Compound of the Invention We examined the ability of the Hsp90 inhibitors of the invention to induce the degradation of c-Met, an Hsp90 client protein that is expressed at high levels in several types of non-small cell lung cancer. NCI-HI 993 (ATCC, cat# CRL-5909) were seeded in 6-v-eIl plates at 5 X 105 cells/weil. 'The cells were treated with 17AAG (100 nM or 400 nM) or Compound 221 (100 nM or 400 nM), and cell lysis was prepared 24 h after treatment. Equal amount of proteins were used for Western blot analysis. The compounds of the invention potently induced degrade tion of c- Met in this cell line due to inhibition of Hsp90 (see Fig. 6). Example 170: Compound 49 Displays Anti-tumor Activity Against the Human Tumor Cell Line MDA-MB-435S in a nude Mouse Xenograft Model The numan rumor cell line, MDA-MB-435S (ATCC #HTB-129; G. Ellison, et al., Uol Pathol. 55:294-299, 2002), was obtained from the American Type Culture Collection (Manassus, Virginia, USA). The cell line was cultured in growth media prepared from 50% Dulbecco's Modified Eagle Medium (high glucose), 50% RPNfl Media 1640, 10% fetal bovine s ^m (FBS), 1% 100X Lglutarnine, 1% 100X Penicillin-Streptomycin, 1% 100X sodium pyruvate and 1% 100X MEM non-essential arhino acids. FBS was obtained from Sigma-Aldrich Corp. (St. Louis, Missouri, USA), and all other reagents were obtained from Invitrqgen Corp. (Carlsbad. California, USA). Approximately 4-5 x 10(6) cells that had been cryopreserved in liquid nitrogen were rapidly thawed at 37°C and transferred to a 175 cm2 tissue culture flask containing 50 ml of growth media and then incubated at 3~°C in a 5% CO: incubator. 'The growth media was replaced every 2-3 days untii the flask became 90% confluent, typically in 5-7 days. To passage and expand the cell line, a 90% confluent flask was washed with 10 ml of room temperature phosphate buffered saline (PBS) and the cells were disassociated by adding 5 ml IX Trypsin-EDTA (Invitrogen) and incubating at 37°C until the cells detached frorr. the surface of the flask. To inactivate the trypsin, 5 ml of growth media was added and thep the contents of the flask were centrifuged to pellet the cells. The supernatant was aspirated and the cell pellet was resuspended in 10 ml of growth media and the cell number determined using a hemocytovneter. Approximately 1-5 \ 10(6) cells per flask were seeded into 175 cm2 flasks containing 50 ml of growth media and incubated at 37°C in a 5% CCn incubator. When the flasks reached 90% confluence, the above passaging process was repeated until sufficient cells had been obtained for implantation into mice. Six to eight week old, female Crl:CD-l-m/BR (nude) mice were obtained from Charles River Laboratories (Wilmington, Massachusetts, USA). Animals were housed 4-5/cage in micro-isolators, with a 12hr/12hr light/dark cycle, acclimated for at least 1 week prior to use and fed normal laboratory chow ad libitum. Studies were conducted on animals between 7 and 12 weeks of age at implantation. To implant tumor cells into nude mice, the cells were trypsinized as above, washed in PBS and resusupended at a concentration of 50 x 10(6) cells/ml in PBS. Using a 27 gauge needle and 1 cc syringe, 0.1 ml of the cell suspension was injected into the corpus adiposum of nude mice. The corpus adiposum is a fat body located in the ventral abdominal vicera in the right quadrant of the abdomen at the juncture of the os coxae (pelvic bone) and the os femoris (femur). Tumors were then permitted to develop in vivo until they reached approximately 150 mm3 in volume, which typically required 2-3 weeks following implantation. Tumor volumes (V) were calculated by caliper measurement of the width (W), length (L) and thickness (T) of tumors using the following formula: V = 0.5326 x (L x W x T). Animals were randomized into treatment groups so that the average tumor volumes of each group were similar at the start of dosing. Sock solutions of test compounds were prepared by dissolving the appropriate amounts of each compound in dimethyl sulfoxide (DMSO) by sonication in an ultrasonic water bath. Stock solutions were prepared at the start of the study, stored at -20°C and diluted fresh each day for dosing. A solution of 20% Cremophore RH40 (polyoxyl 40 hydrogenated castor oil; BASF Corp., Aktiengesellschaft Ludwigshafen, Germany) in 80% D5W (5% dextrose in water; Abbott Laboratories, North Chicago, Illinois, USA) was also prepared by first heating 100% Cremophore RH40 at 50-60°C until liquefied and clear, diluting 1:5 with 100% D5W, reheating again until clear and then mixing well. This solution was stored at room temperature for up to 3 months prior to use. To prepare formulations for daily dosing, DMSO stock solutions were diluted 1:10 with 20% Cremophore RH40. The final formulation for dosing contained 10% DMSO, 18% Cremophore RH40, 3.6% dextrose and 68.4% water and the appropriate amount of test aicicle. Animals were intraperitoneal (IP) injected with this solution at 10 ml per kg body weight on a schedule of 5 days per week (Monday thru Friday, with no dosing on Saturday and Sunday) for 3 weeks. As shown in Figure 7, treatment with 300 mg/kg body weight of Compound 49 decreased the growth rate of MDA-MB-435S cells in nude mice to a greater extent than did a dose of 100 mg/kg body weight of the Hsp90 inhibitor 17-AAG. This effect was not associated with significant toxicity, as shown by the lack of an effect on body weights (Figure 8). Example 171; Compound 188 Displays Anti-tumor Activity Against Human Tumor Cells in a nude Mouse Xenograft Model The human squamous non-small cell lung cancer cell line, RERF-LC-A1 (RCB0444; S. Kyoizumi, et al., Cancer. Res. 45:3274-3281, 1985), was obtained from the Riken Cell Bank (Tsukuba, Ibaraki, Japan). The cell line was "ultured in growth media prepared from 50% Dulbecco's Modified Eagle Medium (high glucose), 50% RPMI Media 1640, 10% fetal bovine serum (FBS), 1% 100X Lglutamine, 1% 100X penicillin-streptomycin, 1% 100X sodium pyruvate and 1% 100X MEM non-essential amino acids. FBS was obtained from American Type Culture Collection (Manassas, Virginia, USA) and all other reagents were obtained from Invitrogen Corp. (Carlsbad, California, USA). Approximately 4-5 x 10(6) cells that had been cryopreserved in liquid nitrogen were rapidly thawed at 37°C and transferred to a 175 cm2 tissue culture flask containing 50 ml of growth media and then incubated at 37°C in a 5% COz incubator. The growth media was replaced every 2-3 days until the flask became 90% confluent, typically in 5-7 days. To passage and expand the cell line, a 90% confluent flask was washed with 10 ml of room temperature phosphate buffered saline (PBS) and the cells were disassociated by adding 5 ml IX trypsin-EDTA (Invitrogen) and incubating at 37°C until the cells detached from the surface of :he flask. To inactivate the trypsin, 5 ml of growth media was added and then the contents of the flask were centrifuged to pellet the cells. The supernatant was aspirated and the cell pellet was resuspended in 10 ml of growth media and the cell number determined using a hemocytometer. Approximately 1-3 x 10(6) cells per flask were seeded into 175 cm. 2.flasks containing 50 ml of growth media and incubated at 37°C in a 5% C02 incubator. When the flasks readied 90% confluence, the above passaging process was repeated until sufficient cells had been obtained for implantation into mice. Seven to eight week old, female Crl:CD-l-m/BR (nude) mice were obtained from Charles River Laboratories (Wilmington, Massachusetts, USA). Animals were housed 4-5/cage in micro-isolators, with a 12hr/12hr light/dark cycle, acclimated for at least 1 week prior to use and fed normal laboratory chow ad libitum. Studies were conducted on animals between 8 and 12 weeks of age at implantation. To implant RERF-LC-AI tumor cells into nude mice, the cells were trypsinized as above, washed in PBS and resuspended at a concentration of 50 x 10(6) cells/ml in 50% non-supplemented RPM1 Media 1640 and 50% Matrigel Basement Membrane Matri:: (#354234; BD Biosciences; Bedford, Massachusetts, USA). Using a 27 gauge needle and 1 cc syringe, 0.1 ml of the cell suspension was injected subcutaneously into the flank of each nude mouse. Tumor volumes (VI were calculated by caliper measurement of the width (W), length (L) and thickness (T) of tumors using the following formula: V = 0.5236 x (L x W x T). In vivo passaged RERF-LC-AI tumor cells (RERF-LC-AI™") were isolated to improve the rate of tumor implantation relative to the parental cell line in nude. mice. RERP-LC-AI tumors were permitted to develop in vivo until they reached approximately 250 mm3 in volume, which required approximately 3 weeks following implantation. Mice were euthanized via COi asphyxiation and their exteriors sterilized %vjth 70% ethanol in a laminar flow hood. Using sterile technique, tumors -.vere excised and diced in 50 ml PBS using a scalpel blade. A single cell suspension was prepared using a 55 ml Wheaton Safe-Grind tissue grinder (catalog £62400-358; VWR International, West Chester, Pennsylvania. USA) by plunging the pestle up and down 4-5 times without twisting. The suspension was strained through a 70 uM nylon cell strainer and then centrifugec to pellet the cells. The resulting pellet was resuspended in 0.1 M NfLtCl to lyse contaminating red blood cells and then immediately centrifuged to pellet the eel!;. The cell pellet was resuspended in growth media and seeded into 175 cm2 flasks containing 50 ml of growth media at 1-3 tumors/flask or approximately 10 x 10(6) cells/flask. After overnight incubation at 37°C in a 5% CO; incubator, nonadherent cells were removed by rinsing two times with PBS and then the cultures were fed with fresh growth media. When the flasks reached 90% confluence, the above passaging process was repeated u.itil sufficient cells had been obtained for implantation into mice. RERF-LC-AI™1" cells were then implanted as above and tumors were permifted to develop in vivo until the majority reached an average of 100-200 mm"' in tumor volume, which typically required 2-3 weeks following implantation. Animals with oblong or very small or large tumors were discarded, and only animals carrying rumors that displayed consistent growth rates were selected for studies. Animals were randomized into treatment groups so that the average tumor volumes of each group were similar at the start of dosing. TheHSP90 inhibitor, 17-a!lylamino-17-demethoxygeldanamycin (17- AAG), was employed as a positive control (Albany Molecular Research, Albany, New York, USA). Stock solutions of test articles were prepared by dissolving the appropriate amounts of each compound in dimethyl sulfoxide (DMSO) by sonication in an ultrasonic water bath. Stock solutions were prepared weekly, stored at -20°C and diluted fresh each day for dosing. A solution of 20% Cremophore RH40 (jx>lyoxyl 40 hydrogenated castor oil; BASF Corp., Aktiengesellschaft. Ludwigshafen, Germany) in 80% D5W (5% dextrose in water: Abbott Laboratories. North Chicago, Illinois, USA) was also prepared by first heating 100% Cremophore RH40 at 50-60°C until liquefied and clear, diluting 1:5 with 100% D5W, reheating again until clear and then mixing well. This solution was stored at room temperature for up to 3 months prior to use. To prepare formulations for daily dosing, DMSO stock solutions were diluted 1:10 with 20° c Cremophore RH40. The final formulation for dosing contained 10% DMSO, 18°o Cremophore RH40. 3.6% dextrose, 68.4% water and the appropriate amount of test article, Animals were intraperitoneally (i.p.) injected with this solution at 10 mi per kg body weight on a schedule of 5 days per week (Monday, Tuesday, Wednesday Thursday and Frida. with no dosing on Saturday and Sunday) for a total of 15 doses. As shown in Figure 9, treatment with 200 mg/kg body weight of Compound 188 decreased the growth rate of RERF-LC-AIIVP human lung tumor cells in nude mice, as did a dose of 75 mg/kg body weight of 17-AAG (an unrelated HSP90 inhibitor). This effect was not associated with overt toxicity, as shown by the minim; 1 effect on body weights depicted in Figure 10. All publications, patent applications, patents, and other documents cited herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting. While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims. We claim:- 1. A compound of 3-(2,4-dihydroxy-5-substituted-phenyl)-4-(substituted-indolyl or substituted-benzimidazole)-5-(mercapto or hydroxyl)-[1,2,4]triazole represented by the following structural formula: (Formula Removed) or a tautomer, pharmaceutically acceptable salt, solvate, or clathrate thereof, wherein: X45 is CR54 or N; Z1 is -OH or -SH; R56 is selected from the group consisting of -H, methyl, ethyl, isopropyl, and cyclopropyl; R52 is selected from the group consisting of -H, methyl, ethyl, n-propyl, isopropyl, n-butyl, n-pentyl, n-hexyl, -(CH2)2OCH3, -CH2C(O)OH, and -C(O)N(CH3)2; R53 and R54 are each, independently, -H, methyl, ethyl, or isopropyl; or R53 and R54 taken together with the carbon atoms to which they are attached form a phenyl, cyclohexenyl, or cyclooctenyl ring; and R55 is selected from the group consisting of -H, -OH, -OCH3, and -OCH2CH3. 2. The compound as claimed in 1 , wherein said compound is 3-(2,4-dihydroxy-5-ethyl- phenyl)-4-(1,3-dimethyl-indol-5-yl)-5-hydroxy-[1,2,4]triazole. 3. The compound as claimed in claim 1 , wherein said compound is selected from the group consisting of: 3-(2,4-dihydroxyphenyl)-4-(1-ethyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxyphenyl)-4-(1-isopropyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxyphenyl)-4-(indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxyphenyl)-4-(1-methoxyethyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-isopropyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxyphenyl)-4-(1-dimethylcarbamoyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-propyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1,2,3-trimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(2,3-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-acetyl-2,3-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-isopropyl-7-methoxy-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-propyl-2,3-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(N-methyl-tetrahydrocarbozol-7-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(N-methyl-cyclononan[a]indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-n-butyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-n-pentyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-n-hexyl-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(1-(1-methylcyclopropyl)-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(1-isopropyl-7-methoxy-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(1,2,3-trimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-isopropyl-7-methoxy-indol-4-yl)-5-mercapto-[1,2,4]triazole disodium salt, 3-(2,4-dihydroxy-5-tert-butyl-phenyl)-4-(1-isopropyl-7-methoxy-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(1-propyl-7-methoxy-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-methyl-3-ethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1,3-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1-isopropyl-7-methoxy-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-methyl-3-isopropyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(N-ethyl-carbozol-7-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-isopropyl-7-hydroxy-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-isopropyl-7-ethoxy-indol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1,2-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(N-methyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1,3-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(1,3-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-cyclopropyl-phenyl)-4-(1-methyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1H-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1,2-dimethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1-ethyl-indol-5-yl)-5-mercapto-[1,2,4]triazole, and 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1-propyl-indol-5-yl)-5-mercapto-[1,2,4]triazole; or a tautomer, pharmaceutically acceptable salt, solvate, or clathrate thereof. 4. The compound as claimed in claim 1, wherein said compound is selected from the group consisting of 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-ethyl-benzimidazol-4-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-ethyl-benzimidazol -4-yl)-5-mercapto-[1,2,4]triazole HCI salt. 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(2-methyl-3-ethyl-benzimidazol-5-yl)-5-mercapto-[1,2,4]triazole, 3-(2,4-dihydroxy-5-ethyl-phenyl)-4-(1-ethyl-2-methyl-benzimidazol-5-yl)-5-mercapto-[1,2,4]triazole, and 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1-methyl-2-trifluoromethyl-benzimidazol-5-yl)-5-mercapto-[1,2,4]triazole; or a tautomer, pharmaceutically acceptable salt, solvate, or clathrate thereof. 5. The compound as claimed in claim 1, wherein said compound is 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(N-methyl-indol-5-yl)-5-mercapto-[1,2,4]triazole; or a tautomer, pharmaceutically acceptable salt, solvate, or clathrate thereof. 6. The compound as claimed in claim 1, wherein said compound is: 3-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(1,3-dimethyl-indol-5-yl)-5-hydroxy-[1,2,4]triazole; or a tautomer, pharmaceutically acceptable salt, solvate, or clathrate thereof. 7. The compound as claimed in claim 1, wherein said compound is: 3-(2,4- dihydroxy-5-isopropyl-phenyl)-4-(1-methyl-indol-5-yl)-5-hydroxy-[1,2,4]triazole; or a tautomer, pharmaceutically acceptable salt, solvate, or clathrate thereof. 8. The compound as claimed in claim 1, wherein said compound is: 3-(2,4- dihydroxy-5-isopropyl-phenyl)-4-(1-isopropyl-indol-4-yl)-5-hydroxy- [1,2,4]triazole; or a tautomer, pharmaceutically acceptable salt, solvate, or clathrate thereof. 9. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and one or more compounds of Claims 1 to 8. 10. The compound as claimed in claim 1 to 8, where said compound used in inhibiting Hsp90 in a cell, for treating or preventing a proliferation disorder in a mammal, or for treating cancer in a mammal, inducing degradation of a c-kit protein, treating a c-kit associated cancer in a mammal, inducing degradation of a c-met protein; or treating a c-met associated cancer in a mammal.

Documents:

3339-DELNP-2007-Abstract-(07-09-2011).pdf

3339-delnp-2007-abstract.pdf

3339-delnp-2007-assignment.pdf

3339-DELNP-2007-Claims-(07-09-2011).pdf

3339-delnp-2007-claims.pdf

3339-DELNP-2007-Correspondence Others-(07-09-2011)..pdf

3339-DELNP-2007-Correspondence Others-(07-09-2011).pdf

3339-delnp-2007-correspondence-others-1.pdf

3339-delnp-2007-correspondence-others.pdf

3339-delnp-2007-description (complete).pdf

3339-DELNP-2007-Drawings-(07-09-2011).pdf

3339-delnp-2007-drawings.pdf

3339-DELNP-2007-Form-1-(07-09-2011).pdf

3339-delnp-2007-form-1.pdf

3339-delnp-2007-form-18.pdf

3339-DELNP-2007-Form-2-(07-09-2011).pdf

3339-delnp-2007-form-2.pdf

3339-DELNP-2007-Form-3-(07-09-2011).pdf

3339-delnp-2007-form-3.pdf

3339-delnp-2007-form-5.pdf

3339-DELNP-2007-GPA-(07-09-2011).pdf

3339-delnp-2007-gpa.pdf

3339-delnp-2007-pct-210.pdf

3339-delnp-2007-pct-304.pdf

3339-delnp-2007-pct-409.pdf

3339-delnp-2007-pct-416.pdf

3339-DELNP-2007-Petition-137-(07-09-2011).pdf