Title of Invention	"A SUBSTITUTED QUINOLINE COMPOUND ACCORDING TO THE GENERAL FORMULA (IA) OR THE GENERAL FORMULA (IB)"
Abstract	A substituted quinoline compound according to the general Formula (Ia) or the general Formula (Ib) wherein R1 to R10, p, q and X are as herein described in specification and claims.

Full Text

The present invention relates to novel substituted quinoline derivatives useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis (M.), M. bovis, M. avium andM. marinum. BACKGROUND OF THE INVENTION Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), a serious and potentially fatal infection with a world-wide distribution. Estimates torn the World Health Organization indicate that more than 8 million people contract TB each year, and 2 million people die from tuberculosis yearly. In the last decade, TB cases have grown 20% worldwide with the highest burden in the most impoverished communities. If these trends continue, TB incidence will increase by 41% in the next twenty years. Fifty years since the introduction of an effective chemotherapy, TB remains after AIDS, the leading infectious cause of adult mortality in the world. Complicating the TB epidemic is the rising tide of multi-drug- resistant strains, and the deadly symbiosis with HIV. People who are HIV-positive and infected with TB are 30 times more likely to develop active TB than people who are HIV-negative and TB is responsible for the death of one out of every three people with HIV/AIDS worldwide. Existing approaches to treatment of tuberculosis all involve the combination of multiple agents. For example, the regimen recommended by the U.S. Public Health Service is a combination of isoniazid, rifempicin and pyrazinamide for two months, followed by isoniazid and rifampicin alone for a further four months. These drugs are continued for a further seven months in patients infected with HIV. For patients infected with multidrug resistant strains of M. tuberculosis, agents such as ethambutol, streptomycin, kanamycin, amikacin, capreomycin, ethionamide, cycloserine, ciprofoxacin and ofloxacin are added to the combination therapies. There exists no single agent that is effective in the clinical treatment of tuberculosis, nor any combination of agents that offers the possibility of therapy of less than six months' duration. There is a high medical need for new drugs that improve current treatment by enabling regimens that facilitate patient and provider compliance. Shorter regimens and those that require less supeivision are the best way to achieve this. Most of the benefit from treatment comes in the first 2 months, during the intensive, or bactericidal, phase when four drugs are given together; the bacterial burden is greatly reduced, and patients become noninfectious. The 4- to 6-month continuation, or sterilizing, phase is required to eliminate persisting bacilli and to minimize the risk of relapse. A potent sterilizing drug that shortens treatment to 2 months or less would be extremely beneficial. Drugs that facilitate compliance by requiring less intensive supervision also are needed. Obviously, a compound that reduces both the total length of treatment and the frequency of drug administration would provide the greatest benefit Complicating the TB epidemic is the increasing incidence of multi-drug- resistant strains or MDR-TB. Up to four percent of all cases worldwide are considered MDR-TB - those resistant to the most effective drugs of the four-drug standard, isoniazid and rifarmpin. MDR-TB is lelhal when untreated and can not be adequately treated through the standard therapy, so treatment requires up to 2 years of "second-line" drugs. These drugs are often toxic, expensive and marginally effective. In the absence of an effective therapy, infectious MDR-TB patients continue to spread the disease, producing new infections with MDR-TB strains. There is a high medical need for a new drug with a new mechanism of action, which is likely to demonstrate activity against MDR strains. The term "drug resistant" as used hereinbefore or hereinafter is a term well understood by the person skilled in microbiology. A drug resistant Mycobacterium is a Mycobacterium which is no longer susceptible to at least one previously effective drug; which has developed the ability to withstand antibiotic attack by at least one previously effective drug. A drug resistant strain may relay that ability to withstand to its progeny. Said resistance may be due to random genetic mutations in the bacterial cell that alters its sensitivity to a single drug or to different drugs. MDR tuberculosis is a specific form of drug resistant tuberculosis due to a bacterium resistant to at least isoniazid and rifampicin (with or without resistance to other drugs), which are at present the two most powerful anti-TB drugs. The purpose of the present invention is to provide novel compounds, in particular substituted quinoline derivatives, having the property of inhibiting growth of Mycobacteria including drug resistant or multi drug resistant Mycobacteria, and therefore useful for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium, M. smegmatis andM. marinum. Substituted quinoUnes were already disclosed in US 5,965,572 (The United States of America) for treating antibiotic resistant infections and in WO 00/34265 to inhibit the growth of bacterial microorganisms. WO 2004/011436 describes quinoline derivatives as antimycobacterial agents. SUMMARY OF THE INVENTION The present invention relates to novel substituted quinoline derivatives according to Formula (la) and (I-b). the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof, wherein : R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alleyl or di(Ar)alkyl; p is an integer equal to 1,2 or 3; -4-xy; thio; alkyloxy optionally substituted with amino or mono or di(alkyl)amino or a radical of formula wherein Z is CH2, CH-R10,0, S, N-R10 and t is an integer equal to 1 or 2 and the dotted line represents an optional bond; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted with one or two substituents each independently be selected from alkyloxy or Ar or Het or morpholinyl or 2-oxopyrrolidinyl; Ar; Het ; t is an integer equal to 1 or 2; and the dotted line represents an optional bond; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is an integer equal to zero, 1,2, 3 or 4; X is a direct bond or CH2R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2H-pyrrolyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidiny], 2-imidazoliny], 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, imidazolidinyl, pyridazinyl, pyrimidinyl, pyrazinyl, '-! triazinyl, morpholinyl and thiomorpholinyl, each of said rings optionally being substituted with alkyl, halo, haloalkyl, hydroxy, alkyloxy, amino, mono- or dialkylamino, alkylthio, alkyloxyalkyl, alkylthioalkyl and pyrimidinyl; R is hydrogen or a radical of formula wherein s is an integer equal to zero, 1, 2,3 or 4; r is an integer equal to 1, 2, 3,4 or 5 ; and Rn is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R11 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; R7 is hydrogen, alkyl, Ar or Het; R9 is oxo; or R8andR9 together fonn the radical-CH=CH-N=; R10 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono-or di(alkyl)aminocarbonyl, AT, Het, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(=O)-, Ar-C(=O)-; alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms ; or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms ; wherein each carbon atom can be optionally substituted with halo, hydroxy, alkyloxy or oxo ; Ar is a homocycle selected from the group of phenyl, naphthyl, acenaphthyl, tetrahydronaphthyl, each optionally substituted with 1,2 or 3 substituents, each substituent independently selected from the group of hydroxy, halo, cyano, nitro, ammo, mono- or dialkylamino, alkyl, haloalkyl, alkyloxy, haloalkyloxy, carboxyl, alkyloxycarbonyl, alkylcarbonyl, aminocarbonyl, morpholinyl and mono- or dialkylaminocarbonyl; Het is a monocyclic heterocycle selected from the group of N-phenoxypiperidinyl, pyrrolyl, pyrazolyl, imidazolyl, furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl; or a bicyclic heterocycle selected from the group of quinoiinyl, isoquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzo[l,4]dioxinyl or benzo[l,3]dioxolyl; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with 1, 2 or 3 substituents selected from the group of halo, hydroxy, alkyl or alkyloxy; halo is a substituent selected from the group of fluoro, chloro, bromo and iodo and haloalkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, wherein one or more carbon atoms are substituted with one or more halo-atoms. provided mat when R is hydrogen then the Rradical may also be placed in position 3 of the quinoline ring. The compounds according to Formula (la) and (Ib) are interrelated in that e.g. a compound according to Formula (Ib), with R9 equal to oxo is the tautomeric equivalent of a compound according to Formula (la) with R2 equal to hydroxy (keto-enol tautomerism). DETAILED DESCRIPTION In the fiamework of this application, alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms ; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms ; or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms ; wherein each carbon atom can be optionally substituted with halo, hydroxy, alkyloxy or oxo. Preferably, alkyl is methyl, ethyl or cyclohexylmethyl. Ci-6alkyl as a group or part of a group encompasses the straight and branched chain saturated hydrocarbon radicals having from 1 to 6 carbon atoms such as, methyl, ethyl, butyl, penty], hexyl, 2-methylbutyl and the like. In the framework of this application, Ar is a homocycle selected from the group of phenyL, naphthyL, acenaphthyl, tetrahydronaphthyl, each optionally substituted with 1,2 or 3 substituents, each substituent independently selected from the group of hydroxy, halo, cyano, nitro, amino, mono- or dialkylamino, alkyl, haloalkyl, alkyloxy, haloalkyloxy, carboxyl, alkyloxycarbonyl, aminocarbonyl, morpholinyl and mono- or dialkylaminocarbonyl. Preferably, Ar is naphthyl or phenyl, each optionally substituted with 1 or 2 substituents selected from halo or alkyl, preferably halo. In the framework of this application, Het is a monocyclic heterocycle selected from the group of N-phenoxypiperidinyl, pyrrolyl, pyrazolyl, imidazolyl, furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl; or a bicyclic heterocycle selected from the group of quinolinyl, isoquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzo[l,4]dioxinyl orbenzo[l,3]dioxolyl; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with 1, 2 or 3 substituents selected from the group of halo, hydroxy, alkyl or alkyloxy. Preferably, Het is ihienyl, fuianyl, imidazolyl, pyridyl, triazolyl, benzo[l,3]dioxolyl, indazolyl, isoquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, benzofuranyl. In the framework of this application, halo is a substituent selected from the group of fluoro, chloro, bromo and iodo and haloalkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, wherein one or more carbonatoms are substituted with one or more halo-atoms. Preferably, halo is bromo, fluoro or chloro and preferably, haloalkyl is trifluoromethyl. In the framework of this application, the quinoline ring of the compounds of formula (la) or (Ib) is numbered as follows: The radical may be placed on any available position of the quinoline moiety. Whenever used hereinafter, the term "compounds of formula (la) or (Ib)" is meant to also include their JV-oxide forms, their salts, their quaternary amines, their tautomeric forms and their stereochemically isomeric forms. Of special interest are those compounds of formula (la) or (Ib) which are stereochemicaUy pure. An interesting embodiment of the present invention relates to those compounds of formula (la) or (Ib), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N- oxide forms thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl ; p is an integer equal to 1 , 2 or 3; R2 is hydrogen; alkyl; hydroxy; thio; alkyloxy optionally substituted with amino or mono or di(alkyl)amino or a radical of formula wherein Z is CH2, CH-R10, 0, S, N-R10 and t is an integer equal tol or 2 and the dotted line represents an optional bond; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted with one or two substituents each independently be selected from alkyloxy or Ar or Het or mrpholinyl oor 2-oxopyrrolidinyl; Het or a radical of formula wherein Z is CH2, CH-R10, O, S, N-R10 ; t is an integer equal to 1 or 2; and the dotted line represents an optional bond; R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is an integer equal to zero, 1, 2, 3 or 4 ; X is a direct bond; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2H-pyrrolyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, imidazolidinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings optionally being substituted with alkyl, halo, haloalkyl, hydroxy, alkyloxy, amino, mono- or dialkylamino, alkylthio, alkyloxyalkyl, alkylthioalkyl and pyrimidinyl; R6 is a radical of formula wherein s is an integer equal to zero, 1, 2, 3 or 4; r is an integer equal to 1, 2, 3,4 or 5 ; and R11 is hydrogen,-9- halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal Ru radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical -CH=CH-N=; R10 is hydrogen, alkyl, aminocarbonyl, mono-or di(alkyl)aminocarbonyl, Ar, Het, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(=O)-; alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms ; or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms ; wherein each carbon atom can be optionally substituted with halo, hydroxy, alkyloxy or oxo; Ar is a homocycle selected from the group of phenyl, naphthyl, acenaphthyl, tetrahydronaphthyl, each optionally substituted with 1,2 or 3 substituents, each substituent independently selected from the group of hydroxy, halo, cyano, nitre, amino, mono- or dialkylamino, alkyl, haloalkyl, alkyloxy, haloalkyloxy, • vr>' carboxyl, alkyloxycarbonyl, alkylcarbonyl, aminocarbonyl, morpholinyl and mono- or dialkylaminocarbonyl; Het is a monocyclic heterocycle selected from the group of N-phenoxypiperidinyl, pyrrolyl, pyrazolyl, imidazolyl, furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl; or a bicyclic heterocycle selected from the group of quinolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzo[l,4]dioxinyl or benzo[l,3]dioxolyl; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with 1, 2 or 3 substituents selected from the group of halo, hydroxy, alkyl or alkyloxy; halo is a substituent selected from the group of fluoro, chloro, bromo and iodo and haloalkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, wherein one or more carbon atoms are substituted with one or more halo-atoms. Preferably, Rn is hydrogen, halo -10-, haloalkyl, hydroxy, AT, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl. Preferably, when R6 is other than hydrogen then R7 is hydrogen and when R7 is other than hydrogen then R6 is hydrogen. Preferably, R6 is other than hydrogen and R7 is hydrogen. Preferably, R7 is other than hydrogen and R6 is hydrogen. Preferably, the invention relates to compounds of Formula (la) and (Ib) wherein : R1 is hydrogen, halo, cyano, Ar, Het, alkyl, and alkyloxy; p is an integer equal to 1,2 or 3; R2 is hydrogen; alkyl; hydroxy; alkyloxy optionally substituted with amino or mono or di(alkyl)amino or a radical of formula wherein Z is CH2, CH-R10,0, S, N-Ria and t is an integer equal to 1 or 2 and the dotted line represents an optional bond; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino; Ar; Het or a radical of formula ,(CH2X wherein Z is CH2, CH-R10,0, S, N-R10; t is an integer equal to 1 or 2; and the dotted line represents an optional bond; R3 is alkyl, Ar, Ar-alkyl or Het; q is an integer equal to zero, 1, 2, or 3 X is a direct bond or CH2; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, imidazolyl, triazolyl, piperidinyl, piperazdnyl, pyrazinyl,morpholinyl and thiomorpholinyl, optionally substituted with alkyl and pyrimidinyl; (Figure Removed) R6 is hydrogen or a radical of formula wherein s is an integer equal zero, 1,2, 3 or 4; r is an integer equal to 1,2, 3,4 or 5 ; and Rn is hydrogen, halo, or alkyl; or two vicinal Rn radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; preferably R11 is hydrogen, halo, or alkyl; r is an integer equal to 1; R7 is hydrogen or Ar; R8 is hydrogen or alkyl; R9 is oxo; or R* and R9 together form fee radical -CH=CH-N=; alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms ; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms ; or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms ; wherein each carbon atom can be optionally substituted with halo or hydroxy ; Ar is a homocycle selected from the group of phenyl, naphthyl, acenaphthyl, tetrahydronaphthyl, each optionally substituted with 1,2 or 3 substituents, each substituent independently selected from the group of halo, haloalkyl, cyano, alkyloxy and morpholinyl; Het is a monocyclic heterocycle selected from the group of N-phenoxypiperidinyl, pyrrolyl, pyrazolyl, imidaz»lyl, ruranyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl; or a bicyclic heterocycle selected flora the group of quinolinyl, isoquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzo[l,4]dioxinyl 01 benzo[l,3]dioxolyl; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with 1, 2 or 3 substituents selected from the group of halo, hydroxy, alkyl or alkyloxy; and halo is a substituent selected from the group of fluoro, chloro and btomo. For compounds according to either Formula (la) and (Ib), preferably, R1 is hydrogen, halo, Ar, Het, alkyl or alkyloxy. More preferably, R1 is hydrogen, halo, alkyl or Het Even more in particular R1 is hydrogen, halo or Het. Most preferably, R1 is halo, in particular bromo. Preferably, p is equal to 1 . Preferably, R2 is hydrogen; alkyl; alkyloxy optionally substituted with amino or mono or di(alkyl)amino or a radical of formula wherein Z is CHk, CH-R10, O, S, N-R10 and t is an integer equal to 1 or 2 and the dotted line represents an optional bond; mono or di(alkyl)amino; Ar, Het or a radical of formula wherein Z is CH2, CH-R10, 0, S, N-R10 ; t is an integer equal to 1 or 2; and the dotted line represents an optional bond. More preferably, R2 is alkyloxy, Het, Ar, alkyl, mono or di(alkyl)amino, a radical of formula wherein Z is CH2, CH-R10, 0, N-R10 ; t is an hiteger equal to 1 or 2; alkyloxy substituted with amino or mono or N Z di(alkyl)amino or a radical of formula wherein Z is CH2, CH-R10, O, N- R10 and t is an integer equal to 1 or 2. Most preferably, R2 is alkyloxy, e.g. methyloxy; lor 2. Preferably, R3 is naphthyl, phenyl or Hel^ each optionally substituted with 1 or 2 substituents, that substituent preferably being a halo or haloalkyl, most preferably being a halo. More preferably, R3 is naphthyl, phenyl, 3,5-dihalophenyl, 1,6-dihalophenyl, thienyl, furanyl, benzofuranyl, pyridyl. Most preferably, R3 is optionally substituted phenyl, e.g. 3,5-dihalophenyl, or naphthyl. Preferably, q is equal to zero, 1 or 2. More preferably, q is equal to 1 . Preferably, R4 and R5 each independently are hydrogen or alkyl, more preferably hydrogen, methyl or ethyl, most preferably methyl.- Preferably R4 and R5 together and including the N to which they are attached form a radical selected from the group of imidazolyl, triazolyl, piperidinyl, piperazinyl and thiomorphoUnyl, optionally substituted with alkyl, halo, haloalkyl, hydroxy, alkyloxy, alkylthio, alkyloxyalkyl or alkylthioalkyl, preferably substituted with alkyl, most preferably substituted with methyl or ethyl. Preferably, R6 is hydrogen or a radical of formula N wherein s is an integer equal to zero, 1 or 2, preferably zero or 1; r is an integer equal to 1 or 2, preferably 1; and R11 is hydrogen, halo, or alkyl, preferably hydrogen or alkyl. More preferably, R6 is a radical of formula . Most preferably, R6 is benzyl or phenyl. Preferably r is 1 and R11 is hydrogen. Preferably, R7 is hydrogen, alkyl or Ar. More preferably hydrogen or Ar, hi particular hydrogen or phenyl. Most preferably R7 is hydrogen. For compounds according to Formula (Ib) only, preferably, R8 is alkyl or hydrogen, preferably hydrogen, and R9 is oxygen. Preferably, R10 is hydrogen, alkyl, hydroxyl, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(=O)-. Most preferably R10 is hydroxyl, Het, alkyl substituted with one Het, alkyl substituted with one Ar. Preferably the compounds of the present invention are compounds according to Formula (la), the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the JV-oxide forms thereof. Preferably X is a direct bond. Preferably X is CH2. An interesting group of compounds are those compounds according to Formula (la) or (Ib), preferably (la), the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof, in which R1 is hydrogen, halo, AT, alkyl or alkyloxy ; p = 1 ; R2 is hydrogen, alkyloxy or alkylthio, R3 is naphthyl, phenyl or thienyl, each optionally substituted with 1 or 2 substituents selected from the group of halo and haloalkyl; q = 0, 1, 2 or 3; R4 and R5 each independently are hydrogen or alkyl or R4 and R5 together and including the N to which mey are attached form a radical selected from the group of imidazolyl, triazolyl, piperidinyl, piperazinyl and thiomorpholinyl; R6 is hydrogen, alkyl or halo; r is equal to 1 and R7 is hydrogen. Also an interesting group of compounds are those compounds according to Formula (la) or (Ib), preferably (la), the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof, wherein R1 is hydrogen, halo, alkyl or Het, wherein Het is preferably pyridyl; R2 is alkyl, alkyloxy optionally substituted with mono or di(alkyl)amino or a radical of formula wherein Z is CH2, CH-R10, O, N-R10, preferably Z is CH2, t is an integer equal to 1 or 2, and R10 is hydrogen, alkyl, hydroxyl, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(=O)-, preferably R10 is hydrogen; Ar; Het; a radical of formula wherein Z is CH2, CH-R10, 0, N-R10 , t is an integer equal to 1 or 2, wherein R10 is hydrogen, alkyl, hydroxyl, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(=O)-; R3 is Ar, preferably phenyl or naphthyl, or Het, preferably thienyl, furanyl, pyridyl, benzofuranyl ,each of said Ar or Het optionally substituted with 1 or 2 substituents that substituent preferably being a halo; R4 and R5 are each alkyl, preferably methyl; R6 is hydrogen, phenyl, benzyl or 4-methylbenzyl; R7 is hydrogen or phenyl; R8 is hydrogen; R9 is oxo. Interesting intermediates of the present invention are intermediates of formula wherein Wi represents a suitable leaving group, such as for example halo, e.g. chloro, bromo and the like, and wherein R1, R3 to R7, X, q and p are as defined hereinabove. The pharmaceutically acceptable acid addition salts are defined to comprise the therapeutically active non-toxic acid addition salt forms which the compounds according to either Formula (la) or (Ib) are able to form. Said acid addition salts can be obtained by treating the base form of the compounds according to either Formula (la) or (Ib) with appropriate acids, for example inorganic acids, for example hydrohalic acid, in particular hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid; organic acids, for example acetic acid, hydroxyacetic acid, propanoic acid, lactic acid, pyruvic acid, oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid, malic acid, tartaric acid, citric acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, cyclamic acid, salicyclic acid, p-aminosalicylic acid and pamoic acid The compounds according to either Formula (la) or (Ib) containing acidic protons may also be converted into their therapeutically active non-toxic base addition salt forms by treatment with appropriate organic and inorganic bases. Appropriate base salts forms comprise, for example, the ammonium salts, the alkaline and earth alkaline metal salts, in particular lithium, sodium, potassium, magnesium and calcium salts, salts with organic bases, e.g. the benzathine, #-methyl-D-glucamine, hybramine salts, and salts with amino acids, for example arginine and lysine. Conversely, said acid or base addition salt forms can be converted into the free forms by treatment with an appropriate base or acid. The term addition salt as used in the framework of this application also comprises the solvates which the compounds according to either Formula (la) or (Ib) as well as the salts thereof, are able to form. Such solvates are, for example, hydrates and alcoholates. The term "quaternary amine" as used hereinbefore defines the quaternary ammonium salts which the compounds of formula (la) or (Ib) are able to form by reaction between a basic nitrogen of a compound of formula (la) or (Ib) and an appropriate quaternizing agent, such as, for example, an optionally substituted alkylhalide, arylhalide or arylalkylhalide, e.g. melhyliodide or benzyliodide. Other reactants with good leaving groups may also be used, such as alkyl trifluoromethanesulfonates, alkyl methanesulfonates, and alkyl p-toluenesulfonates. A quaternary amine has a positively charged nitrogen. Pharmaceutically acceptable counterions include chloro, bromo, iodo, trifluoroacetate and acetate. The counterion of choice can be introduced using ion exchange resins. The term "stereochemically isomeric forms" as used herein defines all possible isomeric forms which the compounds of either Formula (la) or (Ib) may possess. Unless otherwise mentioned or indicated, the chemical designation of compounds denotes the mixture of all possible stereochemically isomeric forms, said mixtures containing all diastereomers and enantiomers of the basic molecular structure . More in particular, stereogenic centers may have the R- or S-configuration; substituents on bivalent cyclic (partially) saturated radicals may have either the cis- or trans-configuration. Stereochemically isomeric forms of the compounds of either Formula (la) or (Ib) are obviously intended to be embraced within the scope of this invention. Following CAS-nomenclature conventions, when two stereogenic centers of known absolute configuration are present in a molecule, an R or S descriptor is assigned (based on Cahn-Ingold-Prelog sequence rule) to the lowest-numbered chiral center, the reference center. The configuration of the second stereogenic center is indicated using relative descriptors or, where R* is always specified as the reference center and indicates centers with the same chirality and indicates centers of unlike chirality. For example, if the lowest-numbered chiral center in the molecule has an S configuration and the second center is /?, the stereo descriptor would be specified as S-[R *,S*]. If "a" and "/3" are used: the position of the highest priority substituent on the asymmetric carbon atom in the ring system having the lowest ring number, is arbitrarily always in the "a" position of the mean plane determined by the ring system. The position of the highest priority substituent on the other asymmetric carbon atom in the ring system relative to the position of the highest priority substituent on the reference atom is denominated "a", if it is on the same side of the mean plane determined by the ring system, or "/3", if it is on the other side of the mean plane determined by the ring system. Compounds of either Formula (la) and (Ib) and some of the intermediate compounds invariably have at least one stereogenic centers in their structure which may lead to at least 2 stereochemically different structures. The compounds of either Formula (la) or (Ib) as prepared in the processes described below may be synthesized in the form of racemic mixtures of enantiomers which can be separated from one another following art-known resolution procedures. The racemic compounds of either Formula (la) or (Ib) may be converted into the corresponding diastereomeric salt forms by reaction with a suitable chiral acid. Said diastereomeric salt forms are subsequently separated, for example, by selective or fractional crystallization and the enantiomers are liberated therefrom by alkali. An alternative manner of separating the enantiomeric forms of the compounds of either Formula (la) or (Ib) involves liquid chromatography using a chiral stationary phase. Said pure stereochemically isomeric forms may also be derived from the corresponding pure stereochemically isomeric forms of the appropriate starting materials, provided that the reaction occurs stereospecifically. Preferably if a specific stereoisomer is desired, said compound will be synthesized by stereospecific methods of preparation. These methods will advantageously employ enantiomerically pure starting materials. The tautomeric forms of the compounds of either Formula (la) or (Ib) are meant to comprise those compounds of either Formula (la) or (Ib) wherein e.g. an enol group is converted into a keto group (keto-enol tautomerism). The N-oxide forms of the compounds according to either Formula (la) or (Ib) are meant to comprise those compounds of either Formula (la) or (Ib) wherein one or several nitrogen atoms are oxidized to the so-called N-oxide, particularly those .N-oxides wherein the nitrogen of the amine radical is oxidized. The invention also comprises derivative compounds (usually called "pro-drugs") of the pharmacologically-active compounds according to the invention, which are degraded in vivo to yield the compounds according to the invention. Pro-drugs are usually (but not always) of lower potency at the target receptor than the compounds to which they are degraded. Pro-drugs are particularly useful when the desired compound has chemical or physical properties that make its administration difficult or inefficient For example, the desired compound may be only poorly soluble, it may be poorly transported across the mucosal epithelium, or it may have an undesirably short plasma half-life. Further discussion on pro-drugs may be found in Stella, V. J. et al, "Prodrugs", Drug Delivery Systems, 1985, pp. 112-176, and Drugs, 1985,29, pp. 455-473. Pro-drugs forms of the pharmacologically-active compounds according to the invention will generally be compounds according to either Formula (la) or (Ib), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof, having an acid group which is esterified or amidated. Included in such esterified acid groups are groups of the formula -COOR, where R is a C1alky!, phenyl, benzyl or one of the following groups : Amidated groups include groups of the formula - CONRHl2, wherein Ry is H, Ci^alkyl, phenyl or benzyl and Rz is -OH, H, Ci-^alkyl, phenyl or benzyl. Compounds according to the invention having an amino group may be derivatised with a ketone or an aldehyde such as formaldehyde to form a Mannich base. This base will hydrolyze with first order kinetics in aqueous solution. The compounds according to the invention have surprisingly been shown to be suitable for the treatment of mycobacterial diseases, particularly those diseases caused by pathogenic mycobacteria, including drug resistant and multi drug resistant mycobacteria, such as Mycobacterium tuberculosis, M. bovis, M. avium, M. smegmatis andM. marinum. The present invention thus also relates to compounds of either Formula (la) or (Ib) as defined hereinabove, the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof, for use as a medicine. The invention also relates to a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of a compound according to the invention. The compounds according to the invention may be formulated into various pharmaceutical forms for administration purposes. As appropriate compositions there may be cited all compositions usually employed for systemically administering drugs. To prepare the pharmaceutical compositions of this invention, an effective amount of the particular compound, optionally in addition salt form, as the active ingredient is combined in intimate admixture with a pharmaceutically acceptable carrier, which carrier may take a wide variety of forms depending on the form of preparation desired for administration. These pharmaceutical compositions are desirable in unitary dosage form suitable, in particular, for administration orally or by parenteral injection. For example, in preparing the compositions in oral dosage form, any of the usual pharmaceutical media may be employed such as, for example, water, glycols, oils, alcohols and the like in the case of oral liquid preparations such as suspensions, syrups, elixirs, emulsions and solutions; or solid carriers such as starches, sugars, kaolin, diluents, lubricants, binders, disintegrating agents and the like in the case of powders, pills, capsules and tablets. Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit forms in which case solid pharmaceutical carriers are obviously employed. For parenteral compositions, the carrier will usually comprise sterile water, at least in large part, though other ingredients, for example, to aid solubility, may be included. Injectable solutions, for example, may be prepared in which the carrier comprises saline solution, glucose solution or a mixture of saline and glucose solution. Injectable suspensions may also be prepared in which case appropriate liquid carriers, suspending agents and the like may be employed. Also included are solid form preparations which are intended to be converted, shortly before use, to liquid form preparations. Depending on the mode of administration, the pharmaceutical composition will preferably comprise from 0.05 to 99 % by weight, more preferably from 0.1 to 70 % by weight of the active ingredient of formula (la) or (Ib), and, from 1 to 99.95 % by weight, more preferably from 30 to 99.9 weight % of a pharmaceutically acceptable carrier, all percentages being based on the total composition. The pharmaceutical composition may additionally contain various other ingredients known in the art, for example, a lubricant, stabilising agent, buffering agent, emulsifying agent, viscosity-regulating agent, surfactant, preservative, flavouring or colorant. It is especially advantageous to formulate the aforementioned pharmaceutical compositions in unit dosage form for ease of administration and uniformity of dosage. Unit dosage form as used herein refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. Examples of such unit dosage forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, suppositories, injectable solutions or suspensions and the like, and segregated multiples thereof. The daily dosage of the compound according to the invention will, of course, vary with the compound employed, me mode of administration, the treatment desired and the mycobacterial disease indicated. However, in general, satisfactory results will be obtained when the compound according to the invention is administered at a daily dosage not exceeding Igram, e.g. in the range from 10 to 50 mg/kg body weight. Further, the present invention also relates to the use of a compound of either Formula (la) or (Ib), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof, as well as any of the aforementioned pharmaceutical compositions thereof for the manufacture of a medicament for the prevention or the treatment of mycobacterial diseases. Accordingly, in another aspect, the invention provides a method of treating a patient suffering from , or at risk of, a mycobacterial disease, which comprises administering to the patient a therapeuticaUy effective amount of a compound or pharmaceutical composition according to the invention. The compounds of the present invention may also be combined with one or more other antimycobacterial agents. Therefore, the present invention also relates to a combination of (a) a compound of formula (la) or (Ib) and (b) one or more other antimycobacterial agents. The present invention also relates to a combination of (a) a compound of formula (la) or (Ib) and (b) one or more other antimycobacterial agents for use as a medicine. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of (a) a compound of formula (la) or (Ib) and (b) one or more other antimycobacterial agents is also comprised by the present invention. The other Mycobacterial agents which may be combined with the compounds of formula (la) or (Ib) are for example rifampicin (=rifampin); isoniazid; pyrazinarnide; amikacin; ethionamide; moxifloxacin; ethambutol; streptomycin; para-aminosalicylic acid; cycloserine; capreomycin; kanamycin; thioacetazone; PA-824; quinolones/fluoroquinolones such as for example ofloxacin, ciprofloxacin, sparfloxacin; macrolides such as for example clarithromycin, clofazimine, amoxycillin with clavulanic acid; rifamycins; rifabutin; rifapentine. Preferably, the present compounds of formula (la) or (Ib) are combined with rifapentin and moxifloxacin. GENERAL PREPARATION The compounds according to the invention can generally be prepared by a succession of steps, each of which is known to the skilled person. Compounds of formula (la) wherein R2 represents alkoxy; a radical of formula radical of formula wherein t and Z are defined as hereinabove; mono or di(alkyl)amino wherein alkyl may optionally be substituted with one or two substituents each independently be selected from alkyloxy or Ar or Het or morpholinyl or 2-oxopyrrolidinyl, said R2 being represented by R2*, and said compounds being represented by formula (Ia-1), can be prepared by reacting an intermediate of formula (II), wherein Wi represents a suitable leaving group, such as for example halo, e.g. chloro and the like, with H-R2a or with a suitable salt form of R28-!! optionally in the presence of a suitable solvent, such as for example an alcohol, e.g. methanol and the like, acetonitrile, and optionally in the presence of a suitable base, such as for example KOH, dipotassium carbonate. -(Figure Removed) Compounds of formula (la) wherein R2 represents Het or alkyl, said R2 being represented by formula R26 and said compounds being represented by formula (Ia-2), can be prepared by reacting an intermediate of formula (II) with R2b-B(OH)2, in the presence of a suitable catalyst, such as for example Pd(PPh3)4, a suitable solvent, such as for example dimethylether or an alcohol, e.g. methanol and the like, and a suitable base, such as for example disodium carbonate or dipotassium carbonate. (Figure Removed) Compounds of formula (la) wherein R2 represents Het, e.g. pyridyl, said R2 being represented by Het and said intermediates being represented by formula (Ia-3), can be prepared by reacting an intermediate of formula (II) with in the presence of a suitable catalyst, such as for example Pd(PPh3)4, a suitable solvent, such as for example dimethylether or an alcohol, e.g. methanol and the like, and a suitable base, such as for example disodium carbonate or dipotassium carbonate. Compounds of formula (la) wherein X is a direct bond, said intermediates being represented by formula (Ia-4), can be prepared by reacting an intermediate of formula (III) wherein W2 represents a suitable leaving group, such as for example halo, e.g. bromo, chloro and the like, with an intermediate of formula (IV) in the presence of a suitable coupling agent, such as for example n-butyl lithium, secBuLi, and in the presence of a suitable solvent, such as for example tetrahydroruran, and optionally in the presence of a suitable base, such as for example 2,2,6,6-tetramethylpiperidine, NH(CH2CH2CH3)2, N3N-diisopropylamine or trimethylethylenediamine. (Figure Removed) Compounds of formula (Ib) wherein R9 represents oxo, can be prepared by reacting an intermediate of formula (IT) with a suitable acid, such as for example HC1, in the presence of a suitable solvent, such as for example tetrahydrofiiran. In the above reactions, the obtained compound of formula (la) or (Ib) can be isolated, and, if necessary, purified according to methodologies generally known in the art such as, for example, extraction, crystallization, distillation, trituration and chromatography. In case the compound of formula (la) or (Ib) crystallizes out, it can be isolated by filtration. Otherwise, crystallization can be caused by the addition of an appropriate solvent, such as for example water; acetonitrile; an alcohol, such as for example methanol, ethanol; and combinations of said solvents. Alternatively, the reaction mixture can also be evaporated to dryness, followed by purification of the residue by chromatography (e.g. reverse phase HPLC, flash chromatography and the like). The reaction mixture can also be purified by chromatography without previously evaporating the solvent. The compound of formula (la) or (Ib) can also be isolated by evaporation of the solvent followed by recrystallisation in an appropriate solvent, such as for example water; acetonitrile; an alcohol, such as for example methanol; and combinations of said solvents. The person skilled in the art will recognise which method should be used, which solvent is the most appropriate to use or it belongs to routine experimentation to find the most suitable isolation method. The compounds of formula (la) or (Ib) may further be prepared by converting compounds of formula (la) or (Ib) into each other according to art-known group transformation reactions. The compounds of formula (la) or (Ib) may be converted to the corresponding N-oxide forms following art-known procedures for converting a trivalent nitrogen into its N-oxide form. Said N-oxidation reaction may generally be carried out by reacting the starting material of formula (la) or (Ib) with an appropriate organic or inorganic peroxide. Appropriate inorganic peroxides comprise, for example, hydrogen peroxide, alkali metal or earth alkaline metal peroxides, e.g. sodium peroxide, potassium peroxide; appropriate organic peroxides may comprise peroxy acids such as, for example, benzenecarboperoxoic acid or halo substituted benzenecarboperoxoic acid, e.g. 3-chlorobenzenecarboperoxoic acid, peroxoalkanoic acids, e.g. peroxoacetic acid, alkylhydroperoxides, e.g. tbutyl hydro-peroxide. Suitable solvents are, for example, water, lower alcohols, e.g. ethanol and the like, hydrocarbons, e.g. toluene, ketones, e.g. 2-butanone, halogenated hydrocarbons, e.g. dichloromethane, and mixtures of such solvents. Compounds of formula (la) wherein R1 represents halo, said compounds being represented by formula (Ia-5), can be converted into a compound of formula (la) wherein R1 represents Het, e.g. pyridyl, said compounds being represented by formula (Ia-6), by reaction with, in the presence of a suitable catalyst, such as for example Pd(PPh3)4, a suitable solvent, such as for example dimethylether or an alcohol, e.g. methanol and the like, and a suitable base, such as for example disodium carbonate or dipotassium carbonate Compounds of formula (Ia-5) can also be converted into a compound of formula (la) wherein R1 represents methyl, said compound being represented by formula (Ia-7), by reaction with Sn(CH3)4 in the presence of a suitable catalyst, such as for example Pd(PPh$)4, a suitable solvent, such as for example toluene. Some of the compounds of formula (I) and some of the intermediates in the present invention may consist of a mixture of stereochemically isomeric forms. Pure stereochemically isomeric forms of said compounds and said intermediates can be obtained by the application of art-known procedures. For example, diastereoisomers can be separated by physical methods such as selective crystallization or chromatographic techniques, e.g. counter current distribution, liquid chromatography and the like methods. Enantiomers can be obtained from racemic mixtures by first converting said racemic mixtures with suitable resolving agents such as, for example, cbiral acids, to mixtures of diastereomeric salts or compounds; then physically separating said mixtures of diastereomeric salts or compounds by, for example, selective crystallization or chromatographic techniques, e.g. liquid chromatography and the like methods; and finally converting said separated diastereomeric salts or compounds into the corresponding enantiomers. Pure stereochemically isomeric forms may also be obtained from the pure stereochemically isomeric forms of the appropriate intermediates and starting materials, provided that the intervening reactions occur stereospecifically. An alternative manner of separating the enantiomeric forms of the compounds of formula (I) and intermediates involves liquid chromatography, in particular liquid chromatography using a chiral stationary phase. It is to be understood that in the above or the following preparations, the reaction products may be isolated from the reaction medium and, if necessary, further purified according to methodologies generally known in the art such as, for example, extraction, crystallization, distillation, trituration and chromatography. Some of the intermediates and starting materials are known compounds and may be commercially available or may be prepared according to art-known procedures. Intermediates of formula (II) wherein X is a direct bond, such intermediates being represented by formula (n-a), can be prepared by reacting an intermediate of formula (V) wherein Wi is as defined hereinabove, with an intermediate of formula (IV) in the presence of a suitable coupling agent, such as nBuLi, secBuLi, and in the presence of a suitable solvent, such as for example tetrahydrofuran, and a suitable base, such as for example 2,2,6,6-tetramethylpiperidine, NH(CH2CH2CH3)2, N,N-diisopropylamine or trimethylethylenediamine. Intermediates of formula (II) wherein X represents CHj, said intermediates being represented by formula (n-b), can be prepared by reacting an intermediate of formula (VI) with an intermediate of formula (IV) in the presence of a suitable coupling agent, such as nBuLi, secBuLi, and in the presence of a suitable solvent, such as for example tetrahydrofuran, and a suitable base, such as for example 2,2,6,6-tetramethylpiperidine, NH(CH2CH2CH3)2, N,,N-diisopropylamine or trimethylethylenediamine.ntennediates of formula (II) wherein R1 is hydrogen, said intermediates being represented by fonnula (II-c), can be prepared by reacting an intermediate of fonnula (V) wherein R1 is halo, said intermediates being represented by fonnula (V-a), with an intermediate of formula (IV), in the presence of a suitable strong base, such as for example nBuLi, secBuLi, and in the presence of a suitable solvent, such as for example tetrahydrofuran.The intermediates of fonnula (V) are compounds that are either commercially available or may be prepared according to conventional reaction procedures generally known in the art. For example, intennediates of formula (V) wherein R7 is hydrogen, R6 is a radical of formula ^ wherein s is an integer equal to 1 and Wi is chloro, said intermediates being represented by formula (V-b) may be prepared according to the following reaction scheme (1):wherein all variables are defined as in Formula (la). Reaction scheme (1) comprises step (a) in which an appropriately substituted aniline is reacted with an appropriate acylchloride such as 3-phenylpropionyl chloride, 3-fluorobenzenepropionyl chloride or p-chlorobenzenepropionyl chloride, in the presence of a suitable base, such as triethylamine and a suitable reaction-inert solvent, such as methylene chloride or ethylene dichloride. The reaction may conveniently be carried out at a temperature ranging between room temperature and reflux temperature. In a next step (b) the adduct obtained in step (a) is reacted with phosphoryl chloride (POCla ) in the presence of a suitable solvent, such as for example -N,N--dimethylformamide (Vilsmeier-Haack formylation followed by cyclization). The reaction may conveniently be carried out at a temperature ranging between room temperature and reflux temperature. It is evident that in the foregoing and in the following reactions, the reaction products may be isolated from the reaction medium and, if necessary, further purified according to methodologies generally known in the art, such as extraction, crystallization and chromatography. It is further evident that reaction products that exist in more than one enantiomeric form, may be isolated from their mixture by known techniques, in particular preparative chromatography, such as preparative HPLC. Typically, compounds of Formula (la) and (Ib) may be separated into their isomeric forms. Intermediates of formula (V-a) wherein Wi represents chloro, said intermediates being represented by formula (V-a-1), can be prepared by reacting an intermediate of formula (YIT) with POC13. Intermediates of formula (VII) can be prepared by reacting an intermediate of formula (VIII) with 4-methylbenzenesulfonyl chloride in the presence of a suitable solvent, such as for example methylene chloride, and a suitable base, such as for example dipotassium carbonate. Intermediates of formula (VIII) can be prepared by reacting an intermediate of formula (EX) with a suitable oxidizing agent, such as for example 3-chlorobenzenecarboperoxoic acid, in the presence of a suitable solvent, such as for example methylene chloride. Intermediates of formula (EX) wherein R6 is hydrogen and R7 is phenyl, said intermediates being represented by formula (EX-a), can be prepared by reacting an intermediate of formula (X) with 3-chloro-1-phenyl-1-propanone in the presence of a suitable acid, such as for example hydrochloric acid, iron chloride hexahydrate, zinc chloride and a suitable solvent, such as for example diethyl ether and a suitable alcohol, e.g. ethanol. ntermediates of formula (IX) wherein R7 is hydrogen and R6 is a radical of formula wherein s is an integer equal to 1, said intermediates being represented by formula (IX-b), can be prepared by reacting an intermediate of formula (XI) in the (Figure Removed) Intermediates of formula (XI) can be prepared by reacting an intermediate of formula (XII) with an intermediate of formula (XIII) in the presence of a suitable base, such as (Figure Removed) Intennediates of formula (TV) are compounds that are either commercially available or may be prepared according to conventional reaction procedures generally known in the art For example, intermediate compounds of Formula (IV) wherein q is equal to 1, said intermediates being represented by formula (IV-a), can be prepared according to the following reaction scheme (2):-31-Scheme 2 Reaction scheme (2) comprises step (a) in which an appropriately R3 is reacted by Friedel-Craft reaction with an appropriate acylchloride such as 3-chloropropionyl chloride or 4-chlorobutyryl chloride, in the presence of a suitable Lewis acid, such as Aids, FeCla, SnCl4, TiCl4 or ZnCl2 and a suitable reaction-inert solvent, such as methylene chloride or ethylene dichloride. The reaction may conveniently be carried out at a temperature ranging between room temperature and reflux temperature. In a next step (b) an amino group (e.g. -NR4R5) is introduced by reacting the intermediate compound obtained in step (a) with an appropriate arnine. Intermediates of formula (IV-a) can also be prepared by reacting an intermediate of formula (XIV) with HC(=O)H and a suitable aminogroup HNR4R5, such as for example NH(CH3)2.HC1 in ihe presence of a suitable solvent, such as for example an alcohol, e.g. methanol, ethanol and the like, and a suitable acid, such as for example hydrochloric acid. Intermediates of formula (VI) wherein Wi represents chloro, said intermediates being represented by formula (Vl-a) can be prepared by reacting an intermediate of formula (XV) with POClj in the presence of benzyltriethylammonium chloride (Phase transfert agent) and a suitable solvent, such as for example acetonitrile. Intermediates of formula (XV) wherein R6 represents a radical of formula wherein s is an integer equal to 1, said intermediates being represented by formula (XV-a), can be prepared by reacting an intermediate of formula (XVI) with NH2-NH2 in the presence of a suitable base, such as for example potassium hydroxide and a suitable solvent, such as for example 1,2-ethanediol. which is an intermediate of formula (XVI) can be prepared by reacting l-(2-aminophenyl)ethanone and p-oxobenzenepropanoic acid ethyl ester. Intermediates of formula (III) wherein R2 represents Ci-gallcyloxy. said intermediates being represented by formula (ffl-a), can be prepared by reacting an intermediate of formula (XVII) with the appropriate C1-6alkylO- salt in the presence of a suitable solvent, such as for example the corresponding Ci-6alkylOH. ntermediates of formula (XVII) can be prepared by reacting an intermediate of formula (XIII) with POC13.-33-Intermediates of formula (XVIII) wherein R7 is hydrogen and R6 represents a radical of (Figure Removed) formula wherein s is an integer equal to 0, said intermediates being represented by formula (XVIII-a), can be prepared by cyclization of an intermediate of formula (X3X) in the presence of AlClj and a suitable solvent, such as for example chlorobenzene. (Figure Removed)In the intermediates of formula (III) the R1 substituent may represent halo and then this halo substituent may take the place of the Wz leaving group. Said intermediates of (Figure Removed) formula (III) being represented by formula The following examples illustrate the present invention without being limited thereto. EXPERIMENTAL PART Of some compounds the absolute stereochemical configuration of the stereogenic carbon atom(s) therein was not experimentally determined. In those cases the stereochemically isomeric form which was first isolated is designated as "A" and the second as "B", without further reference to the actual stereochemical configuration. However, said "A" and "B" isomeric forms can be unambiguously characterized by a person skilled in the art, using art-known methods such as, for example, X-ray diffraction. The isolation method is described in detail below. Hereinafter, the term 'M.P.' means melting point, 'DIPE' means diisopropyl ether, 'DMF' means A^dimethylformamide, 'THF' means tetrahydrofuran, 'EtOAc' means ethyl acetate, 'DCM' means dichloromethane. A. Preparation of the intermediates Example Al Preparation of intermediate 1 l chloride (0.488 mol) was added dropwise at room temperature to a solution of 4-bromo benzenamine (0.407 mol) in Et3N (70ml) and DCM (700ml) and the mixture was stirred at room temperature overnight The mixture was poured out into water and concentrated NH^OH, and extracted with DCM. The organic layer was dried (MgSCU), filtered, and the solvent was evaporated. The residue was crystallized from diethyl elher. The residue (119.67g) was taken up in DCM and washed with HC1 IN. The organic layer was dried (MgSO4), filtered, and the solvent was evaporated, yielding 107.67g of intermediate 1 (87%). Example A2 Preparation of intermediate 2 Phosphoric trichloride (1.225 mol) was added dropwise at 10°C to DMF (0.525 mol). Then intermediate 1 (0.175 mol) was added at room temperature. The mixture was stirred overnight at 80°C, poured out on ice and extracted with DCM. The organic layer was dried (MgSCU), filtered, and the solvent was evaporated The product was used without further purification, yielding 77.62 g of intermediate 2 (67%). Example A3 a) Preparation of intermediate 3 (Figure Removed). A mixture of intermediate 2 (0.233 mol) in a 30% MeONa in MeOH solution (222.32 ml) and MeOH (776 ml) was stirred and refluxed overnight, then poured out on ice and extracted with DCM. The organic layer was separated, dried (MgSCO4), filtered and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: DCM/cyclohexane 20/80 and then 100/0; 20-45urn). The pure fractions were collected and the solvent was evaporated, yielding 25g of intermediate 3 (33%). The following intermediate was prepared according to the method described above. . A mixture of intermediate 2 (0.045 mol) in a 21% EtONa in EtOH solution (50 ml) and EtOH (150 ml) was stirred and refluxed for 12 hours. The mixture was poured out on ice and extracted with DCM. The organic layer was separated, dried (MgSC>4), filtered and the solvent was evaporated, yielding 15.2 g of intermediate 4 (98%). Example A4 a) Preparation of intermediate 5 Aluminum chloride (1.31 mol) was added at room temperature to a mixture of N-(3-bromophenyl)-a-(phenyhnethylene)benzeneacetamide (0.1311 mol) in chlorobenzene (500 ml). The mixture was stirred and refluxed for 3 hours, then cooled to room temperature, poured out into ice water and filtered. The filtrate was washed with H2O, then with cyclohexane and dried, yielding 35.5 g of intermediate 5 (95%). b) Preparation of intermediate 6 and intermediate 7 (Figure Removed) A mixture of intermediate 5 (0.2815 mol) in phosphoric trichloride (320 ml) was stirred and refluxed for 1 hour, then cooled to room temperature and the solvent was evaporated till dryness. The residue was taken up in H2O. The mixture was extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated till dryness. The residue (58.2 g) was purified by column chromatography over silica gel (eluent toluene/cyclohexane 80/20; 15-35um). Two fractions were collected and the solvent was evaporated, yielding 21 g of intermediate 6 and 34.5 g of intermediate 7. c) Preparation of intennediate 8 A mixture of intermediate 6 (0.0659 mol) and a 30 % MeONa in MeOH solution (0.329 mol) in MeOH (300 ml) was stirred and refluxed for 2 days, then cooled to room temperature, poured out into ice water and filtered. The filtrate was washed with H2O and dried, yielding 19 g of intermediate 8 (92%). Example AS a) Preparation of intermediate 9 A mixture of 5-bromo-lH-indole-2,3-dione (0.28 mol) in 3N NaOH (650 ml) was stirred and heated at 80°C for 30 minutes, then cooled to room temperature. Benzenepropanal (0.28 mol) was added and the mixture was stirred and refluxed overnight. The mixture was allowed to cool to room temperature and acidified till pH 5 with HOAc. The precipitate was filtered off, washed with H2O and dried (vacuum), yielding 50 g of intermediate 9 (52%). b) Preparation of intennediate 10 . A mixture of intennediate 9 (0.035 mol) in l,l'-oxybisbenzene (100 ml) was stirred and heated at 300°C for 8 hours, then allowed to cool to room temperature. This procedure was carried out four times. The four mixtures were combined and then purified by column chromatography over silica gel (eluent: DCM/MeOH 100/0, then 99/1). The pure fractions were collected and the solvent was evaporated, yielding 25.6 g of intermediate 10 (61%). Example A6 a) Preparation of intermediate 11-37- HCl/diethyl ether (30 ml) was added to a solution of 4-bromobenzenamine (0.139 mol) in EtOH (250 ml) and the mixture was stirred for 30 minutes. Iron chloride hexahydrate (0.237 mol) and then zinc chloride (0.014 mol) were added and the mixture was stirred at 80°C for 30 minutes. 3-Chloro-l-phenyl-l-propanone (0.146 mol) was added and the mixture was stirred at 80°C for one night The mixture was poured into water and extracted with EtOAc, The organic layer was washed with water, then with KjCOs 10%, dried (MgSO-O, filtered off and evaporated The residue (25 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH 100/0 and then 97/3) (35-70um). The pure fractions were collected and evaporated, yielding 17.5g of intermediate 11 (44%). b) Preparation of intermediate 12 3-Chlorobenzenecarboperoxoic acid (0.12 mol) was added portionwise at room temperature to a solution of intermediate 11 (0.0598 mol) in DCM (200 ml) and the mixture was stirred at room temperature for one night. KaCO3 10% was added, the organic layer was decanted, dried (MgSO*), filtered ofTand evaporated till a volume of 150 ml of intermediate 12 was left, c) Preparation of intermediate 13 4-Methylbenzenesulfonyl chloride (0.075 mol) was added portionwise at room temperature to a solution of intermediate 12 (0.0598 mol) in a 10 % KaCQs solution (150 ml) and DCM (15Qml) and the mixture was stirred at room temperature for one night Diethyl ether was added and filtered off. The precipitate was washed with diethyl ether and evaporated till dryness, yielding 14 g of intermediate 13 (78%). d) Preparation of intermediate 14 A mixture of intermediate 13 (0.047 mol) in phosphoric trichloride (150 ml) was stirred and refluxed for 48 hours. The mixture was evaporated, the residue was taken up in NH4OH and extracted with DCM. The organic layer was dried (MgSO4), filtered off and evaporated, yielding 13 g of intermediate 14 (87%). Example A7 a) Preparation of intermediate 15 A mixture of l-(2-aminophenyl)ethanone (0.37 mol) and p-oxobenzenepropanoic acid ethyl ester (1.48 mol) was stirred at 180°C overnight The mixture was brought to room temperature. The precipitate was filtered, washed with diethyl ether and dried. The residue was crystallized from DIPE. The precipitate was filtered off and dried, yielding 56.6 g of intermediate 15 (58%). b) Preparation of intermediate 16A mixture of intermediate 15 (0.076 mol) and hydrazine (0.76 mol) in 1,2-ethanediol (240 ml) was stirred at 100°C for 1 hour. KOH (0.266 mol) was added. The mixture was stirred at 180°C overnight. HaO was added. The mixture was acidified and extracted with DCM. The organic layer was separated, dried (MgSC^), filtered, and the solvent was evaporated. The residue (12.05 g) was crystallized from DEPE. The precipitate was filtered off and dried, yielding 4.74 g of intermediate 16. c) Preparation of intermediate Phosphoric trichloride (0.057 mol) was added slowly at 80°C to a mixture of intermediate 16 (0.019 mol) and benzyltriethylammonium chloride (0.0532 mol) in acetonitrile (50 ml). The mixture was stirred overnight. The solvent was evaporated. The mixture was poured out into ice and Na2COj 10% and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated, yielding 4.08 g of intermediate 17. Example A8 a) Preparation of intermediate 18 and ntermediate 19 A mixture of aluminium chloride (0.257 mol) and 3-chloropropanoyl chloride (0.234 mol) in 1,2-dichloroethane (100 ml) was stirred at 0°C. A solution of naphthalene (0.234 mol) in 1,2-dichloroethane (100 ml) was added The mixture was stirred at 0°C for 1 hour and poured out into ice water. The organic layer was separated, dried (MgSO4), filtered, and Ihe solvent was evaporated. The residue (56 g) was purified by column chromatography over silica gel (eluent: cyclohexane/DCM 60/40; 20-45um). Two fractions were collected and the solvent was evaporated, yielding 2 fractions, 31 g of fraction 1 as intermediate 18 (61%) and 14 g of fraction 2. Fraction 2 was taken up in DIPE, then the resulting precipitate was filtered off and dried, yielding 8.2 g of intermediate 19. b) Preparation of intermediate 20 (Figure Removed) A mixture of intermediate 18 (0.0137 mol), N--mernylbenzenemethanamine (0.015 mol) and K2CO3 (2 g) in acetonitrile (100 ml) was stirred at 80°C for 2 hours. H2O was added The mixture was extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated, yielding 4.2 g of intermediate 20 (100%). Example A9 Preparation of intermediate 21 A mixture of l-(3,5-difluorophenyl)ethanone (0.013 mol), formaldehyde (0.05 mol) and A^methyhnethanamine hydrochloride (0.052 mol) in concentrated HC1 (O.lml) in EtOH (20 ml) was stirred at 80°C for 20 hours, then cooled to room temperature. The solvent was evaporated till dryness. The residue was taken up in HC13N. The mixture was washed with diethyl ether, basified with KjCOj and extracted with diethyl ether. The organic layer was separated, dried (MgSC>4), filtered, and the solvent was evaporated, yielding 2 g of intermediate 21. Examplc A10 a) Preparation of intermediate 22 and intermediate 23 1.6M Butyllithium (0.12 mol) was added dropwise at -10°C under N2 flow to a solution of 2,2,6,6-tetramethylpiperidine (0.12 mol) in THF (200 ml). The mixture was stirred at -10°C for 20 minutes and then cooled to -70°C. A mixture of intermediate 2 (0.1 mol) in THF (100 ml) was added. The mixture was stirred at -70°C for 45 minutes. A solution of 3-(dimethylamino)-l-phenyl-l-propanone (0.1 mol) in THF (100 ml) was added. The mixture was stirred at -70°C for 1 hour, brought to -50°C and hydrolysed. H2O (100 ml) was added at -50°C. The mixture was stirred at room temperature for 30 minutes and extracted with EtOAc. The organic layer was separated, dried (MgSCU), filtered and the solvent was evaporated. The residue was taken up in EtOAc. The precipitate was filtered off, washed with EtOAc and diethyl ether and dried in vacuo, yielding 4 g of intermediate 23 (8%). The mother layer was evaporated. The residue (26g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NHiOH 97/3/0.1; 15-40um). The desired fractions were collected and the solvent was evaporated. The residue was crystallized from diethyl ether. The precipitate was filtered off and dried, yielding Ig of intermediate 22. The following intermediates were prepared according to the method described above. b) Preparation of intermediate 24 1.6M Butyllithium (0.0094 mol) was added dropwise at -20°C to a mixture of 2,2,6,6-tetramethylpiperidine (0.0094 mol) in THF (20 ml) under N2 flow. The mixture was stirred at -20°C for 20 minutes, then cooled to -70°C. A solution of 6-bromo-2-chloro-3-phenylquinoline (0.0062 mol) in THF (40 ml) was added The mixture was stirred at -70°C for 1 hour. A solution of intermediate 21 (0.0094 mol) in THF (25 ml) was added. The mixture was stirred ftom -70°C to room temperature for 18 hours. HjO and EtOAc were added. The organic layer was washed with saturated NaCl, dried (MgSO4), filtered, and the solvent was evaporated. The residue (4.3 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NH4OH 97/3/0.1; lOum). The pure tractions were collected and the solvent was evaporated, yielding 0.77 g of intermediate 24 (23%). The following intermediates were prepared according to the method described above. c) Preparation of intermediate 28 1.6M Butyllithium (0.029 mol) was added at -10°C to a solution of N-propyl-l-propanamine (0.029 mol) in THF (50 ml) under Ni flow. The mixture was stirred for 20 minutes, then cooled to -70°C. A solution of intermediate 2 (0.024 mol) in THF (30 ml) was added The mixture was stirred at -70°C for 1 hour. A solution of 3-(dimethylamino)-l-(2-thienyl)-l-propanone (0.029 mol) in THF (20 ml) was added The mixture was stirred at -70°C for 1 hour, then brought to -20°C and extracted with EtOAc. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: DCM/MeOH/NH4OH 96/4/0.1; 20-45um). The pure fractions were collected and the solvent was evaporated The residue (4.65 g) was crystallized from DIPE. The precipitate was filtered off and dried, yielding 2.7 g of intermediate 28 (M.P.: 168°C). The mother layer was evaporated yielding another 1.7g of intermediate 28. d) Preparation of intermediate 25 (Figure Removed) 1.6M Butyllithium (0.0112 mol) was added dropwise at -20°C to a solution of N-(l -methylethyl)-2-propanamine (0.0112 mol) in THF (20 ml) under N2 flow. The mixture was stirred at -20°C for 30 minutes, then cooled to -70°C. A solution of intermediate 17 (0.0094 mol) in THF (20 ml) was added. The mixture was stirred for 45 minutes. A solution of intermediate 21 (0.0112 mol) in THF (10 ml) was added The mixture was stirred at -70°C for 2 hours, poured out into H2O at -30°C and extracted with EtOAc. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated The residue (4 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH 98/2; 15-40um). The pure fractions were collected and the solvent was evaporated The residue (3 g) was crystallized from DIPE. The precipitate was filtered off and dried, yielding 1.94 g of intermediate 25 (43%) (M.P.: 140°C). 1.6M Buryllithium (0.013 mol) was add dropwise at -30°C to a mixture of methylethyl)-2-propanamine (0.013 mol) in THF (20 ml) under N2 flow. The mixture stirred at -20°C for 30 minutes, then cooled to -70°C. A solution of 2-chloro-4-methyl-3-phenylquinoline (0.011 mol) in THF (20 ml) was added. The mixture was stirred for 45 minutes. A solution of intermediate 21 (0.013 mol) in THF (10 ml) was added. The mixture was stirred at -70°C for 2 hours, poured out into H2O and extracted with EtOAc. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated. The residue (5 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH 98/2; 15-40um). The pure fractions were collected and the solvent was evaporated, yielding 4 g of intermediate 26 (78%). f) Preparation of intermediate 27 (Figure Removed) 1.6M Butyllithium in hexane (0.0075 mol) was added dropwise at -70°C to a mixture of intermediate 14 (0.0062 mol) in THF (20 ml) under N2 flow. The mixture was stirred at -70°C for 1 hour. A solution of intermediate 21 (0.0075 mol) in THF (10 ml) was added at -70°C. The mixture was stirred from -70°C to room temperature then stirred for 18 hours. H2 The following intermediates were prepared according to the method described above. Example Bl a) Preparation of compound 1 (Figure Removed) 1.6M Butyllithium (0.0019 mol) was added dropwise at -70°C to a mixture of intermediate 8 (0.0016 mol) in THF (5 ml) under Nj flow. The mixture was stirred at 70°C for 1 hour. A solution of intermediate 21 (0.0019 mol) in THF (2 ml) was added. H2O was added. The mixture was extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated The residue was purified by column chromatography over silica gel (eluent: DCM/MeOH/NHUOH 98/2/0.1; lOjam). The pure fractions were collected and the solvent was evaporated, yielding 0.2 g of compound 1 (28%, MH+: 449). The following final compounds were prepared according to the method described above. (Figure Removed)Butyllithium (0.0035 mol) was added dropwise at-20°C to a solution of N-(l-methylethyl)-2-propanamine (0.0034 mol) in THF (10 ml) under N2 flow. The mixture was stirred at -20°C for 20 minutes, then cooled to -70°C. A solution of intermediate (0.0029 mol) in THF (10 ml) was added. The mixture was stirred at -70°C for 2 hours. A solution of intermediate 21 (0.0032 mol) in THF (10 ml) was added at -70°C. The mixture was stirred at —70°C for 3 hours, poured out into ice water and extracted with DCM. The organic layer was separated, dried (MgSO4, filtered, and the solvent was evaporated. The residue (1.4 g) was purified by column chromatography over silica gel (eluent: TX^tf/MeOH/NHiOH 99/1/0.1; 15-40um). The desired fraction was collected and the solvent was evaporated. The residue (0.968 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NKjOH 98/2/0.2; I5-40um). The pure fractions were collected and the solvent was evaporated. The residue was dried, yielding O.lSlg of compound 2 (11%, oil). Example B2 a) Preparation of compound 3 A 30% MeONa solution (2 ml) was added at room temperature to a mixture of intermediate 23 (0.002 mol) in MeOH (2ml). The mixture was stirred and refluxed overnight, poured out on ice and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated. The residue (0.62 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NH4OH 95/5/0.5; 15-40um). The pure fractions were collected and the solvent was evaporated. The obtained residue (0.39 g) was crystallized from DIPE. The precipitate was filtered off and dried, yielding 0.15 g of compound 3 (M.P.: 66°C). The following final compounds were prepared according to the method described above. A mixture of intermediate 25 (0.0004 mol) and pyrrolidine (0.0021 mol) was stirred at 90°C overnight, then poured out into IfeO and extracted with DCM. The organic layer was separated, dried (MgSCU), filtered, and the solvent was evaporated. The residue (0.18 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NH4OH 98/2/0.1; lOum). The desired fraction was collected and the solvent was evaporated, yielding 0.043g of compound 4 (20%, MH+: 516).-49- The following final compounds were prepared according to the method described above. A mixture of intermediate 25,2-iuranylboronic acid (0.0012 mol), tetrakis(triphenylphosphrne)paUadium (0.0013 mol) and a 2M NaiCOs solution (O.i mol) in dimethyl ether (7 ml) was stirred at 90°C overnight, then poured out into H and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered the solvent was evaporated. The residue (0.2 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH 95/5; 15-40um). The pure fractions were collected and the solvent was evaporated The residue (0.12 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NHiOH 99/1/0.1; 20um). The pure tractions were collected and the solvent was evaporated, yielding 0.06g of compound 5 (28%, M.P.: 130°C). The following final compounds were prepared according to the method described above. A mixture of intermediate 35 (0.0005 mol), methylboronic acid (0.0011 mol), tetrakis(triphenylphosphine)palladium (0.0005 mol) and a 2M KaCOs solution (0.0028 mol) in dimethyl ether (10 ml) and MeOH (3 ml) was stirred at 100°C for 24 hours, then cooled to room temperature. HaO was added. The mixture was extracted with EtOAc. The organic layer was washed with saturated NaCl, dried (MgSCU), filtered and the solvent was evaporated. The residue (0.19 g) was purified by column chromatography over kromasil (eluent: DCM/MeOH/NH4OH 95/5/0.1; lOum). The pure fractions were collected and the solvent was evaporated, yielding 0.06 g of compound 6 (28%, MH+: 387, oil). The following final compound was prepared according to the method described above. A mixture of intermediate 23 (0.0019 mol), morpholine (0.0021 mol) and K2CO3 (0.3 g) in acetonitrile (10 ml) was stirred and refluxed overnight, poured out on ice and extracted with DCM. The organic layer was separated, dried (MgS(>4), filtered, and the solvent was evaporated. The residue (0.58 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NRtOH 95/5/01 to 94/6/0.5; 15-40um). The desired fraction was collected and the solvent was evaporated. The obtained residue (0.04 g) was crystallized from DIPE. The precipitate was filtered off and dried, yielding 0.023 g of compound 7 (M.P.: 70°C). The following final compounds were prepared according to the method described above. A mixture of intermediate 27 (0.0005 mol), 3-(l,3,2-dioxaborinan-2-yl)pyridine (0.0008 mol), tetrakis(triphenylphosphine)palladium (0.0005 mol) and a 2M K2CO3 solution (0.0027 mol) in dimethyl ether (7ml) and MeOH (3ml) was stirred at 100°C for 18 hours under N2 flow, then cooled to room temperature. H2O was added. The mixture was extracted with EtOAc. The organic layer was washed with saturated NaCl, dried (MgSO-t), filtered, and the solvent was evaporated. The residue (0.34 g) was taken up in 2-propanone (6 ml). Oxalic aci 58-d was added The mixture was stirred. The precipitate was filtered off and dried at 60°C under a vacuo, yielding 0.29 g of compound 8 as an ethanedioic acid salt (1:2) (80%, M.P.: 151°C). The following final compounds were prepared according to the method described above.g) Preparation of compound 9 A mixture of intermediate 25 (0.0004 mol), 3-(l,3,2-dioxaborinan-2-yl)pyridine (0.0012 mol), tetrakis(triphenylphosphine)palladium (0.00004 mol) and a 2M Na2CO3 solution (0.002 mol) in dimethyl ether (6 ml) was stirred at 90°C overnight, poured out into H2O and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated. The residue (0.33 g) was purified by column chromatography over silica gel (eluent: DCM/MeOH/NH4OH 97/3/0.1; 20um). The desired fraction was collected and the solvent was evaporated, yielding 0.03 g of compound 9 (14%, M.P.: 164°C). h) Preparation of compound 10 A mixture of intermediate 37 (0.0007 mol) in Af-methylmethanamine (10 ml) and acetonitrile (10 ml) was stirred at 90°C for 12 hours, poured out into HzO/KjCCh and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered, and the solvent was evaporated. The obtained fraction (0.25 g) was stirred at 90°C for 72 hours and purified by column chromatography over kromasil (eluent: DCM/MeOH 99/1; lOum). The desired product fraction was collected and the solvent was evaporated. The residue (0.08 g) was dissolved in oxalic acid/2-propanol and converted into the ethanedioic acid salt (1 :2.5). The precipitate was filtered off and dried, yielding 0.07 g of compound 10 (14%, M.P.: 136°C). The following final compounds were prepared according to the method described above. A mixture of KOH (0.0011 mol) in 1-piperidineethanol (2 ml) was stirred at 80°C till KOH disappeared. Intermediate 23 (0.0009 mol) was added The mixture was stirred at 80°C overnight, poured out on ice and extracted with DCM. The organic layer was separated, dried (MgSO,*), filtered, and the solvent was evaporated The residue (2.49 g) was crystallized from DIPE. The precipitate was filtered off and dried, yielding 0.308 g of compound 11 (M.P.: 131°C). The following final compound was prepared according to the method described above. A mixture of intermediate 23 (0.000137 mol), JV-methyhnethanamine (0.000412 mol, 3 equiv.) and KjCOj (3 equiv.) in acetonitrile (2 ml) was stirred at 80°C for 12 hours, poured out into HjO and extracted with DCM. The organic layer was separated, dried (MgSO*), filtered, and the solvent was evaporated. The obtained fraction was purified by column chromatography over silica gel, then the desired product fraction was collected and the solvent was evaporated yielding 0.07 g of compound 78 (54.79%, MH+: 518). The following final compounds were prepared according to the method described above. Example B3 a) Preparation of compound 13 A mixture of compound 12 (0.0003 mol), 3-(l,3,2-dioxaborinan-2-yl)pyridine (0.0006 mol), tetrakis(triphenylphosphine)palladium (0.00003 mol) and a 2M K2COa solution (0.0015 mol) in dimethyl ether (6 ml) and MeOH (2 ml) was stirred at 100°C for 18 hours under N2 flow, then cooled to room temperature. H2O was added. The mixture was extracted with EtOAc. The organic layer was washed with saturated NaCl, dried (MgSO4), filtered, and the solvent was evaporated. The residue (0.14 g) was taken up in 2-propanone (2 ml). Oxalic acid (2 equivalents) was added The mixture was stirred for 10 minutes. The precipitate was filtered, washed with 2-propanone and dried at 70°C under a vacuo, yielding 0.077 g of compound 13 as ethanedioic acid salt (1:1.5) (38%, M.P.: 156°C). The following final compound was prepared according to the method described above. A mixture of compound 3 (0.0003 mol), tetrakis(triphenylphosphine)palladium (0.00003 mol), a 2MNa2CO3 solution (0.0019 mol) and 3-(l,3,2-dioxaborinan-2-yl)pyridine (0.0011 mol) in dimethyl ether (6 ml) was stirred at 100°C overnight, then poured out into H2O and extracted with DCM. The organic layer was separated, dried (MgSO,*), filtered, and the solvent was evaporated. The residue was purified by column chromatography over kromasil (eluent: toluene/2-propanol/NHtOH 80/20/1; lOum). The pure fractions were collected and the solvent was evaporated. The residue (0.1 g, 51%) was crystallized from DIPE/acetonitrile. The precipitate was filtered off and dried, yielding 0.057 g of compound 14 (M.P.: 180°C). The following final compound was prepared according to the method described above. (Figure Removed) A mixture of compound 15 (0.0007 mol), tetrakis(triphenylphosphine)palladium (0.00007 mol) and tetramethylstannane (0.0016 mol) in toluene (6 ml) was stirred and refluxed overnight. HfeO was added. The mixture was extracted with DCM. The organic layer was separated, dried (MgSC4), filtered, and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: DCM/MeOH/NH4jOH 95/5/0.3; 20um). The pure fractions were collected and the solvent was evaporated, yielding 0.038 g of compound 16(11%, MH+: 447). Example B4 Preparation of compound 17 A mixture of intermediate 32 (0.0016 mol) in 6N HC1 (5 ml) and THF (10 ml) was stirred at 80°C for 48 hours, then cooled to room temperature, poured out into a 10 % solution and extracted with EtOAc. The organic layer was washed with saturated NaCl, dried (MgSO.i), filtered and the solvent was evaporated. The residue was crystallized from diethyl ether/2-propanone. The precipitate was filtered off and dried. Part of this fraction (0.3 g of 0.6 g (44%)) was taken up in hot 2-propanone. The precipitate was filtered off and dried, yielding 0.2 g of compound 17 (15%, M.P.: 190°C). C. Analytical methods The mass of the compounds was recorded with LCMS (liquid chromatography mass spectrometry). Three methods were used which are described below. The data are gathered in Table 1 below. LCMS-methodl LCMS analysis was carried out (electrospray ionization in positive mode, scanning mode from 100 to 900 amu) on a Kromasil CIS column (Interchim, Montlucon, FR; 5 um, 4.6 x 150 mm) with a flow rate of 1 ml/minute. Two mobile phases (mobile phase A: 30% 6.5mM ammonium acetate + 40% acetonitrile + 30% formic acid (2ml/l); mobile phase B: 100% acetonitrile) were employed to run a gradient condition from 100 % A for 1 minute to 100% B in 4 minutes, 100% B for 5 minutes to 100 % A in 3 minutes, and reequilibrate with 100 % A for 2 minutes. LCMS-method2 LCMS analysis was carried out (electrospray ionization in both positive and negative (pulsed) mode scanning from 100 to 1000 amu) on a Kromasil CIS column (Interchim, Montlucon, FR; 3.5 um, 4.6 x 100 mm) with a flow rate of 0.8 ml/minute. Two mobile phases (mobile phase A: 35% 6.5mM ammonium acetate + 30% acetonitrile + 35% formic acid (2ml/l); mobile phase B: 100% acetonitrile) were employed to run a gradient condition from 100 % A for 1 minute to 100% B in 4 minutes, 100% B at a flow rate of 1.2 ml/minute for 4 minutes to 100 % A at O.Sml/minute in 3 minutes, and reequilibrate with 100 % A for 1.5 minute. LCMS-method 3 LCMS analysis was carried out (electrospray ionization in positive mode, scanning from 100 to 900 amu) on a Xterra MS CIS column (Waters, Milford, MA; 5 um, 4.6 x 150 mm) with a flow rate of 1 ml/minute. Two mobile phases (mobile phase A: 85% 6.5mM ammonium acetate + 15% acetonitrile; mobile phase B: 20% 6.5 mM ammonium acetate + 80% acetonitrile) were employed to run a gradient condition from 100 % A for 3 minutes to 100% B in 5 minutes, 100% B at a flow rate of 1.2 ml/minute for 6 minutes to 100 % A at O.8ml/minute in 3 minutes, and reequilibrate with 100 % A for 3 minutes. 5 Table 1 : LCMS parent peak (Table Removed) D. Pharmacological examples D.I. In-vitro method for testing compounds against M. tuberculosis. Flat-bottom, sterile 96-well plastic microtiter plates were filled with 100 ul of Middlebrook (Ix) broth medium. Subsequently, stock solutions (10 x final test concentration) of compounds were added in 25 ul volumes to a series of duplicate wells in column 2 so as to allow evaluation of their effects on bacterial growth. Serial fivefold dilutions were made directly in the microtiter plates from column 2 to 11 using a customised robot system (Zymark Corp., Hopkinton, MA). Pipette tips were changed after every 3 dilutions to minimize pipetting errors with high hydrophobic compounds. Untreated control samples with (column 1) and without (column 12) inoculum were included in each microtiter plate. Approximately 5000 CPU per well of Mycobacterium tuberculosis (strain H37RV), in a volume of 100 ul in Middlebrook (Ix) broth medium, was added to the rows A to H, except column 12. The same volume of broth medium without inoculum was added to column 12 in row A to H. The cultures were incubated at 37°C for 7 days in a humidified atmosphere (incubator with open air valve and continuous ventilation). One day before the end of incubation, 6 days after inoculation, Resazurin (1:5) was added to all wells in a volume of 20 ul and plates were incubated for another 24 hours at 37°C. On day 7 the bacterial growth was quantitated fluorometrically. The fluorescence was read in a computer-controlled fluorometer (Spectramax Gemini EM, Molecular Devices) at an excitation wavelength of 530 nm and an emission wavelength of 590 nm. The percentage growth inhibition achieved by the compounds was calculated according to standard methods, and MIC data (representing IC90's expressed in microgram/ml) were calculated. D.2. In-vitro method for testing compounds for anti-bacterial activity against strain M. Smegmatis ATCC607. Flat-bottom, sterile 96-well plastic microtiter plates were filled with 180 ul of sterile deionized water, supplemented with 0.25 % BSA. Subsequently, stock solutions (7.8 x final test concentration) of compounds were added in 45 ul volumes to a series of duplicate wells in column 2 so as to allow evaluation of their effects on bacterial growth. Serial five-fold dilutions (45 ul in 180 ul) were made directly in the microtiter plates from column 2 to 11 using a customised robot system (Zymark Corp., Hopktnton, MA). Pipette tips were changed after every 3 dilutions to minimize pipetting errors with high hydrophobia compounds. Untreated control samples with (column 1) and without (column 12) inoculum were included in each microtiter plate. Approximately, 250 CFU per well of bacteria inoculum, in a volume of 100 ul in 2.8x Mueller-Hinton broth medium, was added to the rows A to H, except column 12. The same volume of broth medium without inoculum was added to column 12 in row A to H. The cultures were incubated at 37°C for 48 hours in a humidified 5% CO2 atmosphere (incubator with open air valve and continuous ventilation). At the end of incubation, two days after inoculation, the bacterial growth was quantitated fluorometrically. Therefore Alamar Blue (l0x) was added to all wells in a volume of 20 ul and plates were incubated for another 2 hours at 50°C. The fluorescence was read in a computer-controlled fluorometer (Cytofluor, Biosearch) at an excitation wavelength of 530 nm and an emission wavelength of 590 nm (gain 30). The % growth inhibition achieved by the compounds was calculated according to standard methods. The pICso was defined as the 50 % inhibitory concentration for bacterial growth. The results are shown in Table 2 We Claim: 1. A substituted quinoline compound according to the general Formula (Ia) or the general Formula (Ib) (Formula Removed) the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof, wherein : R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, N, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, N-alkyl ox di(Ar)alkyl; p is an integer equal to 1,2 or 3; R2 is hydrogen; alkyl; hydroxy; thio; alkyloxy optionally substituted with amino or mono or di(alkyl)amino or a radical of formula (Formula Removed) wherein Z is CH2, CH-R10,O, S, N-R10 and t is an integer equal to 1 or 2 and the dotted line represents an optional bond; alkyloxyalkyloxy; alkylthio; mono or di(aIkyl)amino wherein alkyl may optionally be substituted with one or two substituents each independently be selected from alkyloxy or Ar or Het or morpholinyl or 2-oxopyrrolidinyl; N; Het or a radical of formula (Formula Removed) wherein Z is CH2, CH-R10,O, S: N-R10 ; t is an integer equal to 1 or 2; and the dotted line represents an optional bond; R3 is alkyl, N, N-alkyl, Het or Het-alkyl; q is an integer equal to zero, 1,2, 3 or 4; X is a direct bond or CH2; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 together and including the N to which Ihey are attached amy form a radical selected from the group of pyrrohdinyl, 2H-pyrrolyl,2-pynolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidsnyl, pyridinyl, piperazinyl, imidazolidinyl, pyridazinyl, pyrirmdinyl, pyrazmyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings optionally being substituted with alkyl, halo, haloalkyl, hydroxy, alkyloxy, amino, mono- or dialkylamino, alkylthio, alkyloxyalkyl, alkylthioalkyl and pyrirnidinyl; R6 is hydrogen or a radical of formula (Formula Removed) wherein s is an integer equal to zero, 1,2, 3 or 4; r is an integer equal to 1,2, 3,4 or .5; and R11 is hydrogen, halo, haloalkyl, hydroxy, N, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, N-alkyl or di(Ar)alkyl; or two vicinal R1l radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; R7 is hydrogen, alkyl, N or Het; R8 is hydrogen or alkyl; R9 is oxo; or R8 and R9 together form the radical -CH=CH-N= R10 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono-or di(alkyl)aminocarbonyl, N, Het, alkyl substituted with one or two Het, alkyl substituted with one or two N, Eet-C(=O)-, Ar-C(=O)-; alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms ; or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms ; wherein each carbon atom can be optionally substituted with halo, hydroxy, alkyloxy or oxo; Ar is a homocycle selected from the group of phenyl, naphfhyl, acenaphthyl, tetrahydronaphthyl, each optionally substituted with 1,2 or 3 substituents, each substituent independently selected from the group of hydroxy, halo, cyano, nitro, amino, mono- or dialkylamino, alkyl, haloalkyl, alkyloxy, haloalkyloxy, carboxyl, alkyloxycarbonyl, alkylcarbonyl, aminocarbonyl, morpholinyl and mono- or dialkylarninocarbonyl; Het is a monocyclic heterocycle selected from the group of N-phenoxypiperidinyl, pyrrolyl, pyrazolyl, imidazolyl, furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, isothiazoryl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl; or a bicyclic heterocycle selected from the group of qumolinyl, isoquinolinyl, l,2,3,4-tetrahydroisoquinolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzo[l,4]dioxmyl or benzo[l,3]dioxolyl; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with 1, 2 or 3 substituents selected from the group of halo, hydroxy, alkyl or alkyloxy; halo is a substituent selected from the group of fluoro, chloro, bromo and iodo and haloalkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, wherein one or more carbon atoms are substituted with one or more halo-atoms; provided that when R7 is hydrogen men the (Formula Removed) radical may also be placed in position 3 of the quinoline ring. 2. A compound as claimed in claim 1 provided that when R6 is other than hydrogen then R is hydrogen and when R7 is other than hydrogen then R6 is hydrogen. 3. A compound as claimed in claim 1 or 2 wherein R2 is hydrogen; alkyl; alkyloxy optionally substituted with amino or mono or di(alkyl)amino or a radical of formula (Formula Removed) wherein Z is CH2, CH-R10, O, S, N-R10 and t is an integer equal to 1 or 2 and the dotted line represents an optional bond; mono or di(alkyl)amino; Ar; Het or a radical of formula (Formula Removed) wherein Z is CH2, CH-R10, O, S, N-R10 ; t is an integer equal 1 or 2; and the dotted line represents an optional bond. 4. A compound as claimed in any one of the preceding claims wherein R3 is naphthyl, phenyl or Het, each optionally substituted with 1 or 2 substituents, that substituent being a halo or haloalkyl. 5. A compound as claimed in any one of the preceding claims wherein q is equal to 1. 6. A compound as claimed in any one of the preceding claims wherein R4 arid R5 each independently are hydrogen or alkyl. 7. A compound as claimed in any one of the preceding claims wherein R6 is hydrogen or a radical formula (Formula Removed) wherein s is an integer equal to zero or 1; r is an integer equal to 1 or 2. 8. A compound as claimed in any one of the preceding claims wherein R is hydrogen or Ar. 9. A compound as claimed in claim 1 wherein R1 is hydrogen, halo, alkyl or Het; R is alkyl, alkyloxy optionally substituted with mono or di(alkyl)amino or a radical of formula (Formula Removed) .wherein Z is CH2, CH-R1 , O, N-R10 ; t is an integer equal to 1 or 2, R10 is hydrogen, alkyl, hydroxyl, alkyl substituted with one or two Het, alkyl substituted with one or two N, Het-C(=O)-; R3 is Ar or Het, each optionally substituted with 1 or 2 substituents that substituent being a halo; R4 and R5 are each alkyl; R6 is hydrogen, phenyl, benzyl or 4-methylbenzyl; R7 is hydrogen or phenyl; R8 is hydrogen; R9 is oxo. 10. A compound as claimed in claim 1 wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, N, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is an integer equal to 1,2 or 3; R2 is hydrogen; alkyl; hydroxy; thio; alkyloxy optionally substituted with amino or mono or di(alkyl)amino or a radical of formula (Formula Removed) wherein Z is CH2, CH-R10,O, S, N-R10 and t is an integer equal to 1 or 2 and the dotted line represents an optional bond; alkyloxyalkyloxy; alkylthio; mono or di(alkyI)amino wherein alkyl may optionally be substituted with one or two substituents each independently be selected from alkyloxy or Ar or Het or morpholinyl or 2-oxopyrrolidinyl; Het or a radical of formula (Formula Removed) wherein Z is CH2, CH-R10, O, S, N- R10 ; t is an integer equal to 1 or 2; and the dotted line represents an optional bond; R3 is alkyl, N,Ar-alkyl, Het or Het-alkyl; q is an integer equal to zero, 1,2,3 or 4; X is a direct bond; R4 and R5 each independently are hydrogen, alkyl or benzyl; or R4 and R5 togemer and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2H-pyrrolyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, imidazolidinyl, pyridazinyl, pyrirnidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings optionally being substituted with alkyl, halo, haloalkyl, hydroxy, alkyloxy, amino, mono- or dialkylamino, alkylthio, alkyloxyalkyl, alkylthioalkyl and pyrirnidinyl; R6 is a radical of formula (Formula Removed) wherein s is an integer equal to zero, 1, 2,3 or 4; r is an integer equal to 1,2,3,4 or 5 ; and R11 is hydrogen, halo, haloalkyl, hydroxy, N, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R11 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo ; or R8and R9 together form the radical -CH=CH-N=; R10 is hydrogen, alkyl, aminocarbonyl, mono-or di(alkyl)ammocarbonyl, N, Het, alkyl substituted with one or two Het, alkyl substituted with one or two Ar,N,Het-C(=O)-; alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms ; or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; wherein each carbon atom can be optionally substituted with halo, hydroxy, alkyloxy or oxo; Ar is a homocycle selected from the group of phenyl, naphthyl, acenaphthyl, tetrahydronaphthyL, each optionally substituted with 1,2 or 3 substituents, each substituent independently selected from the group of hydroxy, halo, cyano, nitro, amino, mono- or dialkylamino, alkyl, haloalkyl, alkyloxy, haloalkyloxy, carboxyl, alkyloxycarbonyl, alkylcarbonyl, aminocarbonyl, morpholinyl and mono- or dialkylaminocarbonyl; Het is a monocyclic heterocycle selected from the group of N-phenoxypiperidiiiyl, pyrrolyl, pyrazolyl, imidazolyl, furanyl, thienyl, oxazolyl, isoxazolyl, thiazoryl, isothiazolyl, triazolyl, pyridinyl, pyrirnidinyl, pyrazinyl and pyridazinyl; or a bicyclic heterocycle selected from the group of quinolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzo[l,4]dioxinyl or benzo[l,3]dioxolyl; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with 1, 2 or 3 substituents selected from the group of halo, hydroxy, alkyl or alkyloxy; halo is a substituent selected from the group of fluoro, chloro, bromo and iodo and haloalkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, wherein one or more carbon atoms are substituted with one or more halo-atoms. 11. A compound as claimed in any one of the preceding claims wherein the compound is a compound of formula (Ia). 12. A compound as claimed in any one of the preceding claims for use as a medicine. 13. A composition comprising a pharmaceutically acceptable carrier and as active ingredient, a therapeutically effective amount of a compound as defined in any one of claims 1 to 11. 14. A process for preparing a compound as claimed in claim 1 characterized by a) reacting an intermediate of formula (II) with H-R2a or with a suitable salt form of H- R2a, optionally in the presence of a suitable solvent and optionally in the presence of a suitable base (Formula Removed) wherein W1 represents a suitable leaving group, wherein R2a represents alkoxy; a radical of formula (Formula Removed) wherein t and Z are defined as in claim 1; alkyloxy substituted with a radical of formula (Formula Removed) wherein t and Z are defined as in claim 1; mono or di(alkyl)amino wherein alkyl may optionally be substituted with one or two substituents each independently be selected from alkyloxy or Ar or Het or morpholinyl or 2-oxopyrrolidinyl; and wherein R1, R3 to R7, p, q and X are defined as in claim 1; b) reacting an intermediate of formula (II) with R2b-B(OH)2 in the presence of a suitable catalyst, a suitable solvent, and a suitable base (Formula Removed) wherein W1 represents a suitable leaving group, wherein R2b represents Het or alkyl and wherein R1, R3 to R7, p, q and X are defined as in claim 1; c) reacting an intermediate of formula (II) with (Formula Removed) in the presence of a suitable catalyst, a suitable solvent and a suitable base, (Formula Removed) wherein Wi represents a suitable leaving group and wherein R1, R3 to R7, p, q and X are defined as in claim 1; d) reacting an intermediate of formula (HI) with an intermediate of formula (IV) in the presence of a suitable coupling agent, in the presence of a suitable solvent and optionally in the presence of a suitable base, (Formula Removed) wherein W2 represents a suitable leaving group and wherein R1 to R7, p and q are defined as in claim 1; e) reacting an intermediate of formula (II) with a suitable acid in the presence of a suitable solvent, (Formula Removed) wherein W1 represents a suitable leaving group and wherein R1, R3 to R7, p, q and X are defined as in claim 1; f) converting a compound of formula (Ia-5) into a compound of formula (Ia-6), by reaction with (Formula Removed) in the presence of a suitable catalyst, a suitable solvent, and a suitable base, (Formula Removed) wherein R2 to R7, p, q and X are defined as in claim 1; g) converting a compound of formula (Ia-5) into a compound of formula (Ia-7), by reaction with Sn(CH3)4 in the presence of a suitable catalyst and a suitable solvent, (Formula Removed) wherein R2 to R7, p, q and X are defined as in claim 1; or, if desired, converting compounds of formula (ia) or (Ib) into each other following art-known transformations, and further, if desired, converting the compounds of formula (Ia) or (Ib), into a therapeutically active non-toxic acid addition salt by treatment with an acid, or into a therapeutically active non-toxic base addition salt by treatment with a base, or conversely, converting me acid addition salt form into the free base by treatment with alkali, or converting the base addition salt into the free acid by treatment with acid; and, if desired, preparing stereochemically isomeric forms, quaternary amines, tautomeric forms or N-oxide forms thereof.

Documents:

4218-DELNP-2006-Abstract-(05-10-2010).pdf

4218-delnp-2006-abstract.pdf

4218-DELNP-2006-Claims-(05-10-2010).pdf

4218-delnp-2006-claims.pdf

4218-delnp-2006-correspodence-others.pdf

4218-DELNP-2006-Correspondence-Others-(05-10-2010).pdf

4218-delnp-2006-Correspondence-Others-(19-05-2011).pdf

4218-delnp-2006-correspondence-others-1.pdf

4218-DELNP-2006-Description (Complete)-(05-10-2010).pdf

4218-delnp-2006-description (complete).pdf

4218-DELNP-2006-Form-1-(05-10-2010).pdf

4218-delnp-2006-form-1.pdf

4218-delnp-2006-form-18.pdf

4218-DELNP-2006-Form-2-(05-10-2010).pdf

4218-delnp-2006-form-2.pdf

4218-DELNP-2006-Form-3-(05-10-2010).pdf

4218-delnp-2006-form-3.pdf

4218-delnp-2006-form-5.pdf

4218-DELNP-2006-GPA-(05-10-2010).pdf

4218-delnp-2006-gpa.pdf

4218-delnp-2006-pct-210.pdf

4218-delnp-2006-pct-237.pdf

4218-delnp-2006-pct-304.pdf

4218-delnp-2006-pct-306.pdf

4218-DELNP-2006-Petition-137-(05-10-2010).pdf