Title of Invention

2-(1H-INDOLYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRI

Abstract The present invention relates to aniline derivatives of the general formula I and their use as serotonin reuptake inhibitors and preferably also norepinephrine reuptake inhibitors in the treatment of depression, anxiety, affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD) and stress urinary incontinence.
Full Text

2-(1H-IND0LYLSULFANYL)-BENZYL AMINE DERIVATIVES AS SSRI
FIELD OF THE INVENTION
The present invention relates to compounds which are serotonin reuptake inhibitors and preferably also norepinephrine reuptake inhibitors, and the medical use of such compounds, e.g. in the treatment of depression and anxiety, affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD) and stress urinary incontinence.
BACKGROUND OF THE INVENTION
The majority of currently available antidepressants can be classified in 3 classes:
1) monoamine oxidase inhibitors (MAOIs),
2) biogenic amine neurotransmitter [serotonin (5-HT), norepinephrine (NE) and dopamine (DA)] transporter reuptake blockers, and
3) modulators, especially blockers of one or more of the 5-HT and/or NE receptors.
Since depression is associated with a relative deficiency of the biogenic amines, the use of 5-HT and/or NE-receptor blockers (i.e. 5-HT and or NE-antagonist's) have not proven very successful in the treatment of depression and anxiety and the preferred and currently most efficient treatments are based on the enhancement of 5-HT and/or NE neurotransmission by blocking their reuptake back from the synaptic cleft (Slattery, D.A. et al., "The evolution of antidepressant mcchamsms'\ fundamental and Clinical pharniacology, 2004,18,1-21; Schloss, P, et al, "new insights into the mechanism of antidepressant therapy", Pharmacology and therapeutics, 2004,102, 47-60).
For years monoamine reuptake inhibition has been studied for treatment of depression, i.e. in particular the monoamines serotonin (5-HT), norepinephrine (NE) and dopamine (DA).
Selective serotonin reuptake inhibitors (hereinafter referred to as SSRIs) have become first choice therapeutics in the treatment of depression, certain forms of anxiety and social phobias, because they generally are effective, well tolerated, and have a favourable safety profile compared to the classic tricyclic antidepressants. Drugs claimed to be SSRIs are for example fluoxetine, sertraline and paroxetine.

However, clinical studies on depression indicate that non-response to the known SSRIs is substantial, up to 30%. Another, often neglected, factor in antidepressant treatment is compliance, which has a rather profound effect on the patient's motivation to continue pharmacotherapy. First of all, there is generally a delay in therapeutic effect of the SSRIs. Sometimes symptoms even worsen during the first weeks of treatment. Secondly, sexual dysfunction is generally a side effect common to SSRIs. Without addressing these problems, real progress in the pharmacotherapy of depression and anxiety disorders is not likely to happen. Accordingly, there is a need for the development of compounds capable of improving the treatment of depression and other serotonin related diseases.
A newer strategy has been the development of dual re-uptake inhibitors, e.g., the combined effect of serotonin reuptake inhibition and norepinephrine (norepinephrine is also named noradrenaline, NA) reuptake inhibition on depression is explored in clinical studies of compounds such as Duloxetine (Wong, "Duloxetine (LY-248686): an inhibitor of serotonin and noradrenaline uptake and an antidepressant drug candidate", Expert Opinion on Investigational Drugs, 1998, 7, 10, 1691-1699) and Venlafaxine (Khan-A et al, 30 "Venlafaxine in depressed outpatients", Psychopharmacology Bulletin. 1991,27, 141-144). Compounds having such duel effect are also named SNRIs, "serotonin and noradrenaline reuptake inhibitors", or NSRIs, "noradrenaline and serotonin reuptake inhibitors".
Since treatment with the selective NE reuptake inhibitor reboxetine has been shown to stimulate 5-HT neurons and mediate the release of 5-HT in the brain (Svensson,T. et al, J. Neural. Transmission, 2004, 111, 127) there might be a synergistic advantage using SNRI's in the treatment of depression or anxiety.
The use of SNRI's have been shown in clinical studies to have a beneficial effect on pain (e.g. Fibromyalgia syndrome, overall pain, back pain, shoulder pain, headache, pain while awake and during daily activities) and especially pain associated with depression (Berk, M. Expert Rev. Neurotherapeutics 2003, 3, 47-451; Fishbain, D.A., et al. "Evidence-based data from animal and human experimental studies on pain relief with antidepressants: A structured review" Pain Medicine 2000 1:310-316).

SNRI's have also been shown in clinical studies to have a beneficial effect in attention deficit hyperactivity disorder (ADHD) (N. M. Mukaddes; Venlafaxine in attention deficit hyperactivity disorder, European Neuropsychopharmacology, Volume 12, Supplement 3, October 2002, Page 421).
Furthermore, SNRI's have been shown to be effective for the treatment of stress urinary incontinence (Dmochowski R.R. et al. "Duloxetine versus placebo for the treatment of North American women with stress urinary incontinence", Journal of Urology 2003,170:4, 1259-1263.)
Furthermore, Axford L. et al. describe the development of triple 5-HT. NE and DA reuptake inhibitors for treatment of depression. (2003, Bioorganic & Medical Chemistry Letters, 13, 3277-3280: "Bicyclo[2.2.1.]heptanes as novel triple re-uptake inhibitors for the treatment of depression"). Wellbutrin (bupropion) which has DA re-uptake activity in vitro and in vivo, show antidepressant efficacy. Other combination studies have indicated that addition of some affminity at the DA uptake site may have some clinical benefit (Nelson, J. C. J. Clin. Psychiatry 1998, 59, 65; Masand, P. S. et al Depression Aiixiety 1998, 7, 89; Bodkin, J. A et al. J. Clin. Psychiatry 1997, 58, 137).
The present invention provides 2-(lH-indolylsulfanyl)-benzyl amine derivatives, formula I, which are serotonin reuptake inhibitors. In particular, the invention provides compounds possessing the combined effect of serotonin reuptake inhibition and norepinephrine reuptake inhibition. Furthermore, some of the compounds are also triple 5-HT, NE and DA re-uptake inhibitors.
Diphenyl sulphides of formula (XVI) and variations thereof have been disclosed as serotonin re-uptake inhibitors and have been suggested for use in treatment of depression, cf. e.g. US 5095039, US 4056632, EP 396827 Al and WO 9312080. EP 402097 describes halogen substituted diphenylsulfides claimed to be selective serotonin inhibitors for treatment of depression. Likewise WO 9717325 discloses derivatives of N,N-dimethyl-2-(arylthio)benzylamine claimed to'be selective serotonin transport inhibitors and suggest their use as antidepressants. J. Jilek et al., 1989, Collect. Czeck Chem. Commun., 54, 3294-3338 also_discloses various derivatives of diphenyl sulphides, "phenyl-thio-benzylamines"

as antidepressants. Furthermore, diphenyl sulphides are also disclosed in US 3803143 and claimed useful as antidepressant.

Several publications relates to the use of derivatives of diphenyl sulphides as "radiopharmaceuticals" for imaging SERT by SPECT or PET imaging, e.g. "S. Oya et al. J. Med Chem. 2002, 45, 4716-4723" and "S. Oya et al. J. Med. Chem. 42, 3, 333-335". P. Emond et al (J. Med. Chem (2002) 45, 1253-1258) and HS. Oya et al. (J. Med. Chem. 42, 3, 333-335) further test and discuss substituted "diphenyl sulfides'1 as selective serotonin tranporter ligands relative to dopamine and norepinephrine transporters (DAT, NET) with measurements of vitro affinities at the dopamine, serotonin, and norepinephrine transporters.
WO 0066537 also discloses certain derivatives of diphenyl sulphides claimed to be have higher selectivity for SERT over NET and DAT.
US 4,018,830 and US 4,055,665 discloses "phenylthioaralkylamines" and "2-phenylthiobenzylamines" represented structurally as "Ari-S-Ar2 in which Ar; is aphenylakyl amine substitnent andAri is a substituted or unsubstituted homocyclic or heterocyclic ring of from 5-6 atoms, such as an aromatic ring, a heteroaromatic ring". The compounds are claimed to be useful for preventing "cardiac arrhythmias".
K. Sindelar et al., "Collection of Czechoslovak Chemical Communications, (1991), 56(2), 449-58, by K. Sindelar et al" disclose variations of compounds of formula (XVI) in which one of the rings is substituted with a thiophene ring with test for selectivity as 5-HT reuptake inhibitor and NA re-uptake inhibitor, respectively, for use as antidepressants.

US 6,596,741 B2 and US 6,436,938 Bl and US 6,410,736 Bl disclose biaryl ether derivates (XVII) reported to inhibit reuptake of monoamines, e.g. serotonin, dopamine and/or norepinephrine.
None of the above references disclose compounds comprising an indole group like the indolyl-sulfanyl benzyl amines of the present invention.
SUMMARY OF THE INVENTION
The present invention relates to a compound having the general formula I

wherein the sulphur atom is attached to the indole via any ring carbon of the indole and wherein Rl-R13 are as defined below; as the free base or a salt thereof.
In a further aspect the invention provides a compound of the above formula I according to the above as the free base or a pharmaceutical acceptable salt thereof for use as a medicament.
The invention also provides a pharmaceutical composition comprising a compound according to the above as the free base or a pharmaceutical^ acceptable salt thereof and at least one pharmaceutical^ acceptable carrier or diluent.

The invention further provides a method for the treatment of an affective disorder, such as depression, anxiety disorders including general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia or agoraphobia in a living animal body, including a human, comprising administering a therapeutically effective amount of a compound according to the above as the free base or a salt such as a pharmaceutically acceptable salt thereof. The invention furthermore concerns the use of a compound according to the above in a method of treatment of pain disorders, ADHD and stress urinary incontinence.
The invention further provides the use of a compound according to the above as the free base or a salt such as a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical composition for the treatment an affective disorder, such as depression, anxiety disorders including general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia or agoraphobia. The invention furthermore provides the use of a compound according to the above for the preparation of a pharmaceutical composition for the treatment of pain disorders, ADHD and stress urinary incontinence.
DETAILED DESCRIPTION OF THE INVENTION
Definitions
The term "halogen" means fluoro, chloro, bromo or iodo. "Halo" means halogen.
The expression "Ci-s-alk(en/yn)yl" means a Ci.g-alkyl, a C2-6-alkenyl or a C2-6-alkynyl
group.
The term "Ci-6 alkyl" refers to a branched or unbranched alkyl group having from one to six
carbon atoms inclusive, including but not limited to methyl, ethyl, 1-propyl, 2-propyl,
1-butyl, 2-butyl, 2-methyl-2-propyl and 2-methyl-l -propyl. Similarly, the term "CM alkyl"
refers to a branched or unbranched alkyl group having from one to six carbon atoms
inclusive, including but not limited to methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-
methyl-2-propyl and 2-methyl-l-propyl.
The term "C2-6 alkenyl" designate such groups having from two to six carbon atoms,
including one double bond, including but not limited to ethenyl, propenyl, and butenyl.

The term "C2-6 alkynyl" designate such groups having from two to six carbon atoms, including one triple bond, including but not limited to ethynyl, propynyl and butynyl.
The expression "C3.s-cycloalk(en)yl" means a C3-s-cycloalkyl or a C3.8-cycloalkenyl group. The term "C3.8-cycloalkyl" designates a monocyclic or bicyclic carbocycle having three to eight C-atoms, including but not limited to cyclopropyl, cyclopentyl, and cyclohexyl. The term "C3.8-cycloalkenyr designates a monocyclic or bicyclic carbocycle having three to eight C-atoms and one double bond, including but not limited to cyclopropenyl, cyclopentenyl and cyclohexenyl.
In the expression "C3.s-cycloalk(en)yl-Ci.6-alk(en/yn)yr, the terms uC3.8-cycloalk(en)yl" and "Ci.6-alk(en/yn)yl" are as defined above.
The term "Ci.6~alk(en/yn)yloxy" refers to groups of the formula Ci-6-alk(en/yn)yl-Q-, wherein Ci-6-alk(en/yn)yl are as defined above.
The terms "Ci-6-alk(en/yn)yl-carbonyl", "Ci.6-alk(en/yn)yl-aminocarbonyl" and l In the expressions "Ci-6-alk(en/yn)yl-amino"9 "di-(Gi.6-alkyl)amino", "Ci^-alk(en/yn)ylthio", "halo-Ci_6-alk(en/yn)yl", "halo-Ci.6-alk(en/yn)yl-sulfonyr, "halo-C1-6-alk(en/yn)yl-sulfanyl", "C1-6-alk(en/yn)ylsulfonyl", and !tCi.6-alk(en/yn)ylsuIfanyl" etc., the terms "C1-6-alk(en/yn)yl" and "halo" are as defined above.
The expression "R and R together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring-in addition to said nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur" refers to a heterocylic rings system of a total of 4,5, 6 or 7 members, such as, e.g. azetidine, pyrolidine, piperidine, piperazine, homopiperazine or morpholine. This rings system may be unsubstituted or it may comprise one or more substituents, such as, e.g. a maximum of one or two substituents,

e.g. selected from the group consisting halogen, hydroxy, Ci-e-alkyl, Ci.e-alkoxy, Ci-e-alkylthio, alkylsulphonyl, trifluoromethyl, trifluoromethylsulfonyl, and Ci-e-alkylcarbonyl.
The atoms of the indole are numbered according to IUPAC Commision on Nomenclature of Organic Chemistry guidelines (Rigaudy, J.; Klesney, S. P. Nomenclature of Organic Chemistry Pergamon Press, (1979) ISBN 0080223699).
The term "treatment" as used herein in connection with a disease or disorders includes also prevention as the case may be.
Compounds of the invention
The present invention relates to a compound having the general formula I

wherein the sulphur atom is attached to the indole via any ring carbon of the indole and wherein
- R!-R2 are independently selected from hydrogen, Ci.6-alk(en/yn)yl, C3.g-cycloalk(en)yl, and C3.g"cycloalk(en)yl-Ci-6-alk(en/yn)yl or R1 and R2 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur;
- R -R are independently selected from hydrogen, halogen, cyano, nitro, Ci-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-Ci.6-alk(en/yn)yl5 amino, Ci.6-alk(en/yn)ylamino, di-(Ci.6-alk(en/yn)yl)amino, Ci.6-alk(en/yn)ylcarbonyl, aminocarbonyl, Ci-6-alk(en/yn)ylaminocarbonyl, di-(Ci.6-alk(en/yn)yl)aminocarbonyls hydroxy, Ci_6-alk(en/yn)yloxy? Ci_6-alk(en/yn)ylthio, halo-Ci.6-alk(en/yn)yl, halo-Ci.6-alk(en/yn)ylsulfonyl, halo-Ci-6-alk(en/yn)ylsulfanyl and Ci.6-alk(en/yn)ylsulfonyl; and

- R13 is selected from hydrogen, Ci-6-alk(en/yn)yl, C3-8-cycloalk(en)yl .and
C3-8-cycloalk(en)yl-Ci-6-alk(en/yn)yl;
as the free base or a salt thereof; with the provisos that:
- when the sulphur atom is attached via atom nr. 2 of the indole then R7 does not exist;
- when the sulphur atom is attached via atom nr. 3 of the indole then R12 does not exist;
- when the sulphur atom is attached via atom nr. 4 of the indole then R8 does not exist;
- when the sulphur atom is attached via atom nr. 5 pf the indole then R9 does not exist;

- when the sulphur atom is attached via atom nr. 6 of the indole then R10 does not exist; and
- when the sulphur atom is attached via atom nr. 7 of the indole then R1} does not exist.
To further illustrate the invention, without limitation, the following embodiments of R -R
are within the scope of the invention, in particular for the compounds of the invention as the
free base and the salts thereof:
R^R2 are independently selected from hydrogen, Ci-6-alk(en/yn)yl, C3.8-cycloalk(en)yl and
C3.8-cycloalk(en)yl-Ci-6-alk(en/yn)yl;
R*-R2 are independently selected from hydrogen and Ci-e-alkyl;
Rl-R2 are independently selected from hydrogen and CM-alkyl;
R is hydrogen and R is methyl;
R1 and R2 are methyl;
R1 and R2 are hydrogen.
To farther illustrate the invention, without limitation, the following embodiments of R*-R2 are within the scope of the invention, in particular for the compounds of the invention as the free base and the salts thereof:
R*-R2 are independently selected from hydrogen and Ci-tj-alk(en/yn)yl; or R1 and R2 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally the ring in addition to the nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur.

To further illustrate the invention, without limitation, the following embodiments of Rl-R2 are also within the scope of the invention, in particular for the compounds of the invention as the free base and the salts thereof:
R1 and R2 together with the nitrogen form a 4-7, i.e. including 5 or 6. membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one farther heteroatom selected from nitrogen, oxygen and sulphur, which ring system is unsubstituted;
R1 and R2 together with the nitrogen form a 4-7, including 5 or 6, membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur, which ring system comprises one or more substituents, such as, e.g. a maximum of one or two substituents, e.g. selected from the group consisting of hydroxy, Ci-6-alkyl (e.g. methyl), halogen (e.g. fluoro or chloro), Ci-6-alkoxy (e.g. methoxy), Ci-6-alkylthio, alkylsulphonyl, trifluoromethyl, trifluoromethylsulfonyl and Ci^-alkylcarbonyl;
R1 and R2 together with the nitrogen form a ring selected from the group consisting of azetidine, pyrolidine, piperidine, piperazine, homopiperazine or morpholine, which ring may be unsubstituted or it may comprise one or more substituents, such as, e.g. a maximum of one or two substituents, e.g. selected from the group consisting of hydroxy, Ci-6-alkyl (e.g. methyl), halogen (e.g. fluoro or chloro), Ci.6-alkoxy (e.g, methoxy), Ci-6-alkylthio, alkylsulphonyl, trifluoromethyl, trifluoromethylsulfonyl and Ci-6-alkylcarbonyl.
To further illustrate the invention, without limitation, the following embodiments of R3-R12
are within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R -R are independently selected from hydrogen, halogen, cyano, Ci-g-alkyl,
C3-8-cycloalkyl, C3.g-cycloalkyl-C1-.6-alkyl, Ci_6-alkyloxy, C1-6-alkylthio and
trifluoromethyl;
R -R are independently selected from hydrogen, chloro, fluoro, cyano, methyl, methoxy,
methylthio and trifluoromethyl;
R3-R12 are hydrogen:
R3-R12 are independently selected from hydrogen and halogen;
R3-R12 are independently selected from hydrogen, chloro and fluoro;
R3-R12 are independently selected from hydrogen and chloro;

R3-R12 are independently selected from hydrogen and fluoro;
at least one of R3-R12 is fluoro or chloro;
R3-R12 are selected independently from hydrogen and cyano;
R3-R12 are selected independently from hydrogen and Ci-6-alk(en/yn)yl;
R3-R12 are selected independently from hydrogen and Ci.6-alkyls such as methyl;
R3-R12 are selected independently from hydrogen and Ci-*-alk(en/yn)yloxy, preferably
Ci-6-alkoxy, such as methoxy;
R3-R12 are selected independently from hydrogen and.Ci-6-alkylthio, such as methylthio;
R3-R12 are selected independently from hydrogen and trifluoromethyl.
Within the invention, are embodiments where:
a limited number of R3-R12 are different from hydrogen, e.g. at least 3, or at least 5 or at
least 6 of R3-R12 are hydrogen;
all of R3-R12 are hydrogen;
only 1,2, 3 or 4 of R3-R12 is different from hydrogen.
In one embodiment of the invention only 1, 2 or 3 of R3-R12 are different from hydrogen,
preferably selected independently from the group consisting of hydrogen, chloro, fluoro,
cyano, methyl, methoxy, methylthio and trifluoromethyl.
To further illustrate the invention, without limitation, the following embodiments of R3-R12
are within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R -R are independently selected from hydrogen, halogen, cyano, Ci-6-alk(en/yn)yl,
C3-s-cycloalk(en)yl, Ca-s-cycloalkCenJyl-Ci.e-alkCen/^ylj'hydroxy, Ci-6-alk(en/yn)yloxy
and halo-Cifc6-alk(en/yn)yl;
are independently selected from hydrogen, halogen, cyano, Cj.6-alk(en/yn)yl, hydroxy, Ci_6-alk(en/yn)yloxy and halo-Ci.6-alk(en/yn)yl; one of R -R is halogen such as chloro or bromo or iodo or fluoro; one of R3-R12 is cyano;
one of R3-R12 is C]-6-alk(en/yn)yl, such as Ci-s-alkyl, e.g. methyl or ethyl; one of R3-R12 is hydroxy;
one of R3-R12 is Ci_6-alk(en/yn)yloxy, such as d-e-alkyloxy, e.g. methoxy; one of R3-R12 is halo-Ci.6-alk(en/yn)yl such as halo-Ci-6-alkyl, e.g, trifluoro-methyl. Within the invention, are embodiments where:

one of R3-R12 is different from hydrogen; two of R3-R12 are different from hydrogen; three of R3-R12 are different from hydrogen; four of R3-R12 are different from hydrogen.
To further illustrate the invention, without limitation, the following embodiments of R3-R6
are within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R3-R6 are independently selected from hydrogen, halogens cyano, nitro, Ci.6-alk(en/yn)yl,
C3-B-cycloalk(en)yls C3.g-cycloalk(en)yl-Ci.6-alk(en/yn)yl, amino, Ci.6-alk(en/yn)ylamino,
di-(Ci.6-alk(en/yn)yl)amino1 Ci-6-alk(en/yn)ylcarbonyl, aminocarbonyi,
Ci-6-alk(en/yn)ylaminocarbonyls di-(Ci-6-alk(en)yl)aminocarbonyl, hydroxy,
Ci-6-alk(en/yn)yloxys Ci-6-alk(en/yn)ylthio, halo-Ci.6-alk(en/yn)yl, halo-
Ci.6-alk(en/yn)ylsulfonyl, halo-Ci-6-alk(en/yn)ylsulfanyl and Ci-6-alk(en/yn)ylsulfonyl;
R3-R6 are independently selected from hydrogen, halogen, cyano, Cu-alkyl,
C3-B-cycloalkyl, C3.B-cycloalkyl-Ci.6-alkyl, amino, C^-alkylamino, di-(Ci.6-a!kyl)amino,
Ci-6-alkylcarbonyl, aminocarbonyl, Ci-6-alkylaminocarbonyl, di-(Ci.e-alkylamino)carbonyl,
hydroxy, Ci_e-alkoxy, Ci_6-alkylthio, halo-Ci-g-alkyl, halo-Ci.6-alkylsulfonyl. halo-
Ci.6-alkylsulfanyl and Cj.e-alkylsulfonyl;
R3-R6 are independently selected from hydrogen, halogen, Ci-6-alkyloxy and Ci-g-alkyl;
R3-R6 are independently selected from hydrogen, halogen, methoxy and methyl;
R3-R6 are independently selected from hydrogen, fluoro, chloro, methoxy and methyl.
Within the invention, are embodiments where a limited number of R3-R6 are different from
hydrogen, e.g.;
only one or two of R3-R6 is different from hydrogen;
three of R -R are hydrogen and one of R -R is halogen;
three of R3-R6 are hydrogen and one of R3-R6 is methyl;
R4 is different from hydrogen;
R is different from hydrogen;
R4 is different from hydrogen, e.g. chloro, fluoro, methyl or methoxy, and the rest of R3-R6
is hydrogen;
R5 is different from hydrogen, e.g. chloro, fluoro, methyl or methoxy, and the rest of R3-R6
is hydrogen;

only one of R3-R6 is different from hydrogen and is selected from the group consisting of fluoro, chloro, methyl and methoxy; R3-R6 are hydrogen.
To further illustrate the invention, without limitation, the following embodiments of R -R
are within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R3-R6 are independently selected from hydrogen, halogen, cyano, Ci.6-alk(en/yn)yl,
C3-8-cycloalk(en)yl and C3.8-cycloalk(en)yl-Ci.6-alk(en/yn)yl;
R3-R6 are independently selected from hydrogen, halogen and Ci-6-alk(en/yn)yl;
R3 is hydrogen;
R4 is selected from hydrogen, halogen and Ci-6-alk(en/yn)yl;
R4 is hydrogen;
R4 is halogen such as chloro or fluoro;
R4 is Ci.6-alk(en/yn)yl such as Ci-6-alkyl e.g. methyl;
R5 is selected from hydrogen and halogen;
R3 is hydrogen;
R5 is halogen such as chloro;
R6 is hydrogen.
To further illustrate the invention, without limitation, the following embodiments of R7-R12 are within the scope of the invention, in particular for the compounds as the free base or salt thereof:
R7-R12 are independently selected from hydrogen, halogen, cyano, nitro, Ci.6-alk(en/yn)yl, C3-8-cycloaIk(en)yl, C3-8-cycloalk(en)yl-Ci-6-alk(en/yn)yl, amino, Ci-6-alk(en/yn)ylamino, di-(C1-6-alk(en/yn)yl)aminosC1-.6-alk(en/yn)ylcarbonyl, aminocarbonyl, Ci-6-alk(en/yn)ylaminocarbonyl?di-(Ci.6-alk(en)yl)aminocarbonyls hydroxy, Ci-6-alk(en/yn)yloxy, Ci_$-alk(eivyn)ylthio, halo-Ci.6-alk(en/yn)yl, halo-Ci-6-alk(en/yn)ylsulfonyl, halo-C].6-alk(en/yn)ylsulfanyl and Ci.6-alk(en/yn)yIsulfonyl. Within the invention, are embodiments where a limited number of R7-R12 are different from hydrogen, e.g.: only one or two of R -R1" is different from hydrogen;

only one of R7-R12 is different from hydrogen and the substituent is selected from the group consisting of hydrogen, methyl, fluoro, chloro or methoxy; only two of R7-R12 is different from hydrogen and the suhstituents are selected independently from the group consisting of hydrogen, methyl, fluoro, chloro or methoxy.
To further illustrate the invention, without limitation, the following embodiments of R7-R12
are within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R7-R12 are independently selected from hydrogen, halogen, cyano, Ci.6-alk(en/yn)yl,
C3-8-cycloalk(en)yl, C3.8-cycloalk(en)yl-Ci-6-alk(en/yn)yl, hydroxy, Ci-6-alk(en/yn)yloxy
and halo-Ci_6-alk(en/yn)yl;
R7-R12 are independently selected from hydrogen, halogen, cyano, Ci-6-alk(en/yn)yl,
hydroxy, Ci-6-alk(en/yn)yloxy and ha!o-Ci-6-alk(en/yn)yl;
R7 is selected from hydrogen and Ci-6-alk(en/yn)yl;
R7 is Ci-6-alk(en/yn)yl such as Ci-s-alkyl;
R8 is selected from hydrogen, halogen, cyano, Ci.6-alk(en/yn)yl, hydroxy and
Ci.6-alk(en/yn)yloxy;
R8 is hydrogen;
R8 is halogen such as fluoro, chloro or bromo;
Rs is cyano;
R8 is Ci-6-alk(en/yn)yl such as Ci.e-alkyi e.g. methyl;
Rs is hydroxy;
R8 is Ci-6-alk(en/yn)yloxy such as Q-e-alkyloxy e.g. methoxy;
R9 is selected from hydrogen, halogen, cyano, Ci.6-alk(en/yn)yl, hydroxy and
Ci.6-alk(en/yn)yloxy;
R9 is hydrogen;
R9 is halogen such as fluoro, chloro, iodo or bromo;
R9 is cyano;
R9 is Ci.6-alk(en/yn)yl such as Ci-6-alkyl e.g. methyl;
R9 is hydroxy;
R9 is Ci-6-alk(en/yn)yloxy such as Cu-alkyloxy e.g. methoxy;
R10 is selected from hydrogen, halogen, cyano, Ci-6-alk(en/yn)yl, hydroxy,
Ci-6-alk(en/yn)yloxy and halo-Ci.6-alk(en/yn)yl;

R10 is hydrogen;
R10 is halogen such as fluoro, chloro or bromo;
R10 is cyano;
R10 is Ci-6-alk(en/yn)yl such as Ci-e-alkyl e.g. methyl;
R10 is hydroxy;
R10 is Ci-6-alk(en/yn)yloxy such as Ci-e-alkyloxy e.g. methoxy;
R10 is halo-Ci-6-alk(en/yn)yl such as halo-Ci.6-alkyl e.g. trifluoro-methyl;
R11 is selected from hydrogen, halogen, Ci.6-alk(en/yn)yl and Ci-6-alk(en/yn)yloxy;
R1] is hydrogen;
Ru is halogen such as fluoro or chloro;
R11 is Ci.6-alk(en/yn)yl such as C:.6-&lkyl e.g. methyl or ethyl;
Rn is Ci.6-alk(en/yn)yloxy such as Ci-e-alkyloxy e.g. methoxy;
R12 is selected from hydrogen and Ci-6~alk(en/yn)yl;
R12 is hydrogen;
R12 is Ci_6-alk(en/yn)yl such as Ci-6-alkyl e.g. methyl.
To further illustrate the invention, without limitation, the following embodiments of R7 are
within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R7 is hydrogen;
R7 is methyl.
To farther illustrate the invention, without limitation, the following embodiments of R13 is
within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R13 is selected from hydrogen and Ci-6-alk(en/yn)yl;
R13 is hydrogen;
R13 is Ci-6-alk(en/yn)yl such as Ci-e-alkyl e.g. methyl.
The above embodiments relates to the compounds of the invention having formula I

In particular, the present invention relates to a compound having the general formula I wherein the sulphur atom is attached to the indole as indicated in below formulas IA to IF:

and wherein R!-R13 are as defined herein, in particular wherein
R!-R2 are independently selected from hydrogen, Ci-6-alk(en/yn)yl (e.g, methyl), C3-8-cycloalk(en)yl, C3-s-cycloalkyl-Ci-6-alkyl, or

R1 and R2 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally the ring in addition to the nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur;
R -R are independently selected from hydrogen, halogen (e.g. fluoro or chloro), cyano, nitro, Cj.6-alk(en/yn)yl (e.g. Ci-6-alkyl, such as methyl), C3.g-cycloalk(en)yl (e.g. C3-g-cycloalkyl), C3.s-cycloalk(en)yl-Ci-6-alk(en/yn)yl (e.g. C3-s-cycloalkyl-Ci-e-alkyl), amino, Ci.6-alk(en/yn)ylamino (e.g. Ci-6-alkylamino), di-(Ci-6-alk(en/yn)yl)amino (e.g. di-(Ci.6-alkyl)amino), Ci.6-alk(en/yn)ylcarbonyl (e.g. Ci-b-alkylcarbonyl), aminocarbonyl, Ci„6-alk(en/yn)ylaminocarbonyl (e.g. Ci-e-alkylaminocarbonyl), di-(Ci_6-alk(en)yl)aminocarbonyl (e.g. di-(Ci-6-alkyl)aminocarbonyl)), hydroxy, Ci.e-alk(en/yn)yloxy (e.g. Ci_6-alkoxy; such as methoxy), Ci_6-alk(en/yn)ylthio (e.g. Ci-e-alkylthio, such as methylthio), halo-Ci-6-alk(en/yn)yl (e.g., halo-Ci-e-alkyl, such as trifluoromethyl), halo-Ci-6-aIk(en/yn)ylsulfonyl (e.g. trifluoromethylsulfonyl), halo-Ci-6-alk(en/yn)ylsulfanyl (e.g. trifluoromethylsulfanyl), and Ci-6-alk(en/yn)ylsulfonyl (e.g. Ci-6-alkylsulfonyl); R13 is selected from hydrogen, Ci.6-alk(en/yn)yl (e.g. Ci-6-alkyl, such as methyl), C3-8-cycloalk(en)yl (e.g. Cs-s-cycloalkyl), andC3.s-cycloalk(en)yl-Ci.6-alk(en/yn)yl (e.g. C3-s-cycloaLkyl-Ci-6«alkyl); as the free base or a salt thereof.
A preferred embodiment relates to the compounds of the invention having formula IA. Any
of the above embodiments are also embodiments of formula IA with the proviso that R12
does not exist in compounds of general formula IA.
Another embodiment relates to the compounds of the invention which are not of formula
IA.
A further embodiment relates to the compounds of the invention having formula IB. Any of the above embodiments are also embodiments of formula IB with the proviso that R7 does not exist in compounds of general formula IB. Another embodiment relates to the compounds of the invention which are not of formula IB.

A further embodiment relates to the compounds of the invention having formula IC. Any of the above embodiments are also embodiments of formula IC with the proviso that R8 does not exist in compounds of general formula IC. Another embodiment relates to the compounds of the invention which are not of formula IC.
A further embodiment relates to the compounds of the invention having formula ID. Any of
the above embodiments are also embodiments of formula ID with the proviso that R9 does
not exist in compounds of general formula ID.
Another embodiment relates to the compounds of the invention which are not of formula
ID.
A further embodiment relates to the compounds of the invention having formula IE. Any of the above embodiments are also embodiments of formula IE with the proviso that R10 does not exist in compounds of general formula IE. Another embodiment relates to the compounds of the invention which are not of formula IE.
A further embodiment relates to the compounds of the invention having formula IF. Any of the above embodiments are also embodiments of formula IF with the proviso that Ru does not exist in compounds of general formula IF. Another embodiment relates to the compounds of the invention which are not of formula IF.
To further illustrate the invention, without limitation, the following embodiments of formula
IA are within the scope of the invention, in particular for the compounds as the free base or
salt thereof: R8-R11 are independently selected from hydrogen, halogen, cyano, Ci-e-alkyl,
C3-8-cycloalkyl, C3.s-cycloalkyl-Ci-6-alkyl, amino, Ci.g-alkylamino, di-(Ci_6-alkyl)amino,
Ci-6-alkylcarbonyl, aminocarbonyl, Ci^-alkylaminocarbonyl, di-(Ci-6-alkylamino)carbonyl,
hydroxy, Ci-6-alkoxy? Ci-6-alkylthio, halo-Ci-6-alkyl, halo-Ci-e-alkylsulfonyl, halo-
Ci-e-alkylsulfanyl, and Ci-e-alkylsulfonyl;
R8-R11 are independently selected from hydrogen, halogen, cyano, methyl, hydroxy,
methoxy and trifluoromethyl;
R8-Rn are independently selected from hydrogen, halogen, methyl and methoxy;
R8-Rn are independently selected from hydrogen, fluoro, chloro, methyl and methoxy.

Within the invention, are embodiments where a limited number of R8-Rn are different from
hydrogen, e.g.:
only one of R8-Rn is different from hydrogen and preferably selected from the group
consisting of hydrogen, fluoro, chloro, methyl and methoxy, while rest of Rs-Ru are
hydrogen;
two of R8'11 are different from hydrogen and preferably selected from the group consisting
of hydrogen, fluoro, chloro, methyl and methoxy while and two of R8'11 are hydrogen.
To further illustrate the invention, without limitation, the following embodiments of formula
IA are within the scope of the invention, in particular for the compounds as the free base or
salt thereof:
R8 is selected from the group consisting of halogen (preferably fluoro or chloro). methyl and
methoxy and R7 and R9"11 are hydrogen;
R9 is selected from the group consisting of halogen (preferably fluoro or chloro), methyl and
methoxy and R7, Rs and R10"11 are hydrogen.
To further illustrate the invention, without limitation, the following embodiments of formula IA are within the scope of the invention, in particular for the compounds as the free base or salt thereof: only one of R " is different from hydrogen and is selected from the group consisting of halogen (e.g. fluoro or chloro), methyl, methoxy, hydroxy and cyano.
To further illustrate the invention, without limitation, the following embodiments of formula IA are within the scope of the invention, in particular for the compounds as the free base or salt thereof: R8 is hydroxy; R8 is methoxy; R8 is methyl; R8 is cyano; R8 is chloro; R8 is fluoro; in a
S 1 1
preferred embodiment, the rest of R to R are hydrogen.
To further illustrate the invention, without limitation, the following embodiments of formula IA are within the scope of the invention, in particular for the compounds as the free base or salt thereof:
R9 is fluoro; R9 is chloro; R9 is bromo; R9 is iodo; R9 is methoxy; R9 is methyl; R9 is hydroxy; in a preferred embodiment, the rest of R8 to Ru are hydrogen.

To further illustrate the invention, without limitation, the following embodiments of formula IA are within the scope of the invention, in particular for the compounds as the free base or salt thereof:
R10 is fluoro; R10 is chloro; R10 is bromo; R10 is methyl; R10 is cyano; R10 is CF3; R10 is methoxy; in a preferred embodiment, the rest of R8 to Ru are hydrogen.
To further illustrate the invention, without limitation, the following embodiments of formula IA are within the scope of the invention, in particular for the compounds as the free base or salt thereof:
R11 is methyl; Rn is ethyl; Ru is methoxy; R11 is chloro; R11 is fluoro; in a preferred embodiment, the rest of Rs to R11 are hydrogen.
To further illustrate the invention, without limitation, the following embodiments of formula IA are within the scope of the invention, in particular for the compounds as the free base or salt thereof: R10 and R11 are selected independently from the group consisting of hydrogen, methyl, fluoro and chloride.
To further illustrate the invention, without limitation, the following embodiments of R13 are
within the scope of the invention, in particular for the compounds as the free base or salt
thereof:
R13 is hydrogen;
R13 is Ci-6-alkyl;
R13 is d-4-alkyl;
R13 is methyl.
One embodiment, relates to compounds of formula IA, wherein R13 is hydrogen or a
Ci-e-alkyl, e.g. a Ci-4-alkyl, such as methyl and where R^R11 are as defined herein.
To further illustrate the invention, without limitation, the following embodiment are within the scope of the invention, in particular for the compounds as the free base or salt thereof: the compound has the formula IA where R1 is hydrogen, R2 is hydrogen or Ci-e-alkyl, preferably C-M-alkyl, such as methyl, R3-R6 are independently selected from hydrogen, methyl and halogen, e.g. chloro or fluoro, R7 is hydrogen or methyl, R8"11 are independently selected from hydrogen, methyl, methoxy and halogen, e.g. chloro or fluoro, and R13 is

hydrogen, and where at most one or two of R8-Ru are different from hydrogen and at most one or two of R3-R6 are different from hydrogen.
In a further embodiment, the compound according to the invention is selected from the following list: Compound no. Compound name
1 [2-(lH-Indol-3-ylsulfanyl)benzyl] dimethyl amine
2 [2-(5-cyano-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
3 [2-(4-Fluoro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
4 [2-(4-Chloro-lH-indol-3-ylsulfanyl)benzyI] dimethyl amine
5 [2-(5-Fluoro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
6 [2-(5-Chloro-lH-indol-3-ylsulfanyI)benzyl] dimethyl amine
7 Dimethyl-[2-(7-methyl-lH-indol-3-ylsulfanyl)benzyl]-amine
8 [2-(7-Methoxy-lH-indol-3-ylsulfanyl)benzyI] dimethyl amine
9 [2-(5-Methoxy-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
10 [2-(6-Fluoro-lH-indol-3-ylsulfanyl)benzyI] dimethyl amine
11 [2-(6-Chloro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
12 Dimethyl-[2-(2-methyl-lH-indol-3-ylsulfanyl)benzyl]-amine
13 Dimethyl-[2-(6-methyl-lH-indol-3-ylsulfanyl)benzyI]-amine
14 [2-(4-cyano-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
15 Dimethyl-[2-(l -methyl- lH-indol-3-ylsulfanyl)benzyl] amine
16 Dimethyl-[2-(4-methyl-lH-indol-3-ylsulfanyl)benzyl] amine
17 [2-(4-Hydroxy-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
18 [2-(6-cyano-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
19 [2«(7-Chloro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
20 [2-(6-Methoxy-lH-indol-3-ylsulfanyl)benzyI] dimethyl amine
21 [2-(4-Methoxy-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
22 [2-(lH-IndoI-3-ylsulfanyI)benzyI]methyl amine
23 [2-(6-Fluoro-lH-indol-3-ylsulfanyI)benzyl]methyl amine
24 [2-(5-Fluoro-lH-indol-3-ylsulfanyl)benzyl]methyl amine
25 Methyl-[2-(4-methyl-lH-indol-3-ylsulfanyl)benzyl] amine
26 [2-(4-Chloro-lH-indol-3-ylsulfanyl)benzyl]methyl amine
27 Methyl-[2-(2-methyl-lH-indol-3-ylsulfanyl)benzyl] amine
28 [2-(5-Fluoro-2-methyl-lH-indol-3-yIsulfanyl)-benzyl]methyl amine
29 Methyl-[2-(5-methyHH-indol-3-ylsulfanyl)benzyl] amine

30 Methyl-[2-(7-methyl«lH-indol-3-ylsulfanyl)benzyl] amine
31 [2-(4-Fluoro-lH-indol-3-ylsulfanyl)benzyl]methyl amine
32 [2-(7-Ethyl-lH-indol-3-ylsulfanyl)ben2yl]methyl amine
33 [2-(6-Methoxy-lH-indol-3-ylsulfanyl)benzyl]methyl amine
34 [2-(5-Chloro-lH-indol-3-ylsulfanyl)ben2yl]methyl amine
35 [2-(6-Chloro-lH-indol-3-ylsulfanyl)benzyl]methyl amine
36 [2-(5-Methoxy-4-methyl-lH-indol-3-ylsulfanyl)-benzj'l]methyl amine
37 [2-(5,6-Dimethoxy-lH-indol-3-ylsulfanyl)-benzyI]methyl amine
38 [2-(6-Bromo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
39 Methyl-[2-(6-methyl-lH-indol-3-ylsulfanyl)-benzyl] amine
40 [2-(4,7-Dimethoxy-lH-indol-3-ylsulfanyl)-ben2yl]methyl amine
41 [2-(5-Methoxy-lH-indol-3-ylsulfanyl)benzyl]methyl amine
42 [2-(4-Methoxy-lH-indoI-3-ylsulfanyI)benzyl]methyl amine
43 [2-(5-Bromo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
44 [2-(7-Methoxy-lH-indol-3-ylsulfanyl)benzyI]methyl amine
45 [5-Chloro-2-(lH-indol-3-ylsulfanyl)-benzyl]methyl amine
46 Methyl-[2-(6-trifluoromethyl-lH-indol-3-ylsulfanyl)-benzyl] amine
47 [2-(5-Hydroxy-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
48 [2-(4-Bromo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
49 [2-(7-Chloro-lH-indol-3-ylsulfanyl)-benzj'l]methyl amine
50 [2-(5-Iodo-lH-indol-3-ylsulfanyl)-benz>4]methyl amine
51 [2-(6-Cyano-lH-indol-3-ylsulfanyl)-benzyl]methyI amine
52 [2-(lH-Indol-3-ylsulfanyl)-5-methyl-benzyl]methyl amine
53 Methyl-[2-(3-methyl-lH-indol-2-ylsulfanyl)-benzyl] amine
54 [2-(5,6-Dimethoxy-lH-indol-3-ylsulfanyl)-5-fluoro-ben2yl]-methyl-amine
55 [5-Fluoro-2-(3-methyI-lH-indol-2-ylsulfanyl)-benzyl]-methyl-amine
56 [5-FIuoro-2-(4-fluoro-lH-indol"3-ylsulfanyl)-benzyl]-methyl-amine
57 [2-(4-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
58 t2-(7-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
59 f5-Fluoro-2«(6-trifluoromethyl-lH-indol-3-ylsulfanyl)-ben2yl]-methyl-amine
60 f5-Fluoro-2»(7-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
61 [2-(4-Bromo-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl«amine
62 3-(4-FluorO"2-methylaminomethyl-phenylsulfanyl)-2-methyl-lH-indol-4-ol
63 3-(4-FIuoro-2-methylaminomethyl-phenylsulfanyl)-lH"indol-6-ol
64 [5-Fluoro-2»(5-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine

65 [5-Fluoro-2-(4-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
66 [2-(6-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
67 [2-(5-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
68 [5-Fluoro-2-(6-methyl-lH-indol-3-ylsuIfanyl)-benzyI]-methyl-amine
69 [5-Fluoro-2-(5-methoxy-4-methyl-lH-indol-3-ylsulfanyI)-benzyl]-methyl-aniine
70 [2-(5-Bromo-lH-indol-3-ylsulfanyl)-5-fluorb-benzyl]-methyl-amine
71 [5-Fluoro-2-(5-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl»amine
72 [2-(6-Bromo-lH-indol-3-ylsulfanyI)-5-fluoro-benzyl]-methyl-amine
73 [5-Fluoro-2-(6-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
74 [5-FIuoro-2-(6-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
75 [5-Fluoro-2-(2-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
76 [5-Fluoro-2-(5-methyl-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
77 [5-Fluoro-2-(4-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
78 [5-Fluoro-2-(7-methyl-lH-indol-3-ylsulfanyl)-benz};l]-methyl-arnine
79 [5-Fluoro-2-(l-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
80 [5-Fluoro-2-(5-fluoro-2-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
81 [5-Chloro-2-(5-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl»amine
82 [5-ChIoro-2-(5-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
83 [5-Chloro-2-(7-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
84 [5-Chloro-2-(l-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
85 [5-ChlorO"2-(4-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
86 [5-Chloro-2-(7-methoxy-lH-indol-3-ylsulfanyl)-benzj'l]-methyl-amine
87 [5-Chloro-2-(6-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
88 [5-Chloro-2-(5-fluoro-2-methyl-lH-indol-3-ylsulfanyl)-benz>'l]-methyI-amine
89 [2-(5-Fiuoro-2-methyl-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine
90 Methyl-[5-methyl-2-(4-methyl-lH-indol-3-ylsulfanyl)-ben2yl]-amine
91 [2-(7-Ethyl-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine
92 [2-(6-Methoxy-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine
93 Methyl-[5-methyl-2-(2-methyl-lH-indol-3-ylsulfanyl)-benzyl]-amine
94 [2-(4-Methoxy-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine
95 [2-(6-Bromo-lH-indol-3-ylsulfanyl)«5-methyl-benzyl]-methyl-amine
96 [2-(6-Fluoro-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine
97 [2-(4-Fluoro-lH-indol-3-yIsulfanyl)-5-methyI-benzyl]-methyl-amine
98 3-(4-Methyl-2-methylaminomethyl-phenylsulfanyl)-lH-indol-6-ol
99 [5-Chloro-2-(5-methyl-lH-indol-3-ylsulfanyl)-benzyI]-methyl-amine

100 [2-(6-Chloro-lH-indol-3-ylsulfanyl)-S-methyl-benzj'l]-methyl-ainine
101 [2-(5-Chloro-lH-indol-3-ylsulfanyl)-5-methyl-benzyI]-methyl-amine
102 5-Fluoro-3-(2-piperidin-l-ylmethyl-phenyIsulfanyl)-lH-indole
103 5-Fluoro-3-(2-morpholin-4-ylmethyl-phenylsuIfanyl)- 1H- indole
104 5-FIuoro-3-(2-pyrrolidin-l-ylmethyl-phenylsulfanyl)-lH-indole
105 f4-Chloro-2-(6-methyl-lH-indol-3-ylsuIfanyl)-benzyl]-methyl-amine
106 [4-Chloro-2-(2-methyl-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
107 [4-Chloro-2-(5-methyl-lH-indol-3-ylsuIfanyl)-benzyl]-methyl-amine
108 [4-Chloro-2 109 [4-Chloro-2-(4-methyl-lH-iridol-3-ylsulfanyl)-benzyI]-methyl-amine
110 [4-Chloro-2-(S-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
111 [4-Chloro-2-(6-fluoro-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
112 [4-Chloro-2-(4-fluoro-lH-indol-3-ylsulfanyI)-benzyl]-methyl-araine
113 [4-Chloro-2-(7-fluoro-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
114 [4-Chloro-2-(7-ethyl-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
115 [4-Chloro-2-(S-methoxy-4-methyl-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
116 [4-Chloro-2-(5-methoxy- lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
117 [4-Chloro-2-(6-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
US [4»Chloro-2-(7-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
119 [4-Chloro-2-(4-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
120 [4-Chloro-2-(5-chloro-lH-indol-3-ylsuIfanyl)-benzyl]-methyl-amine
121 [4-Chloro-2-(6-chloro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
122 [4-Chloro«2-(4-chloro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
123 [4-Chloro-2-(7-chloro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
124 t4-Chloro-2-(lH-indol-3-ylsulfanyl)-ben2yl]-methyl-amine
125 [4-Chloro-2-(l-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
126 [4-Chloro-2-(3 -methyl- lH-indol-2-ylsuIfanyl)-benzyl]-methyl-amine
127 [4-Chloro-2-(5-fluoro-2-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
128 2-(5-Fluoro-lH-indol-3-ylsulfanyl)-benzylamine
129 [2-(5-Fluoro-4-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
130 [2-(4,5-Difluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
131 [2-(4f6-Difluoro-lH-indol-3-ylsulfanyl)-benzy]]-methyl-amine
132 3-(2-Methylaminomethyl-phenylsuIfanyI)-lH-indol-4-ol
133 2-(6-Fluoro-lH-indol-3-ylsulfanyl)-benzylamine
134 [2-(5f6-Difluoro-lH-indol-3-ylsulfanyl)-ben2yl]-methyl-amine

135 6-Fluoro-3-(2-methylaminomethyl-phenylsulfanyl)-lH-indol-5-ol
136 [2-(4-ChIoro-lH«indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine
137 [2-(lH-Indol»5-ylsulfanyl)-benzyl]-methyl-amine
138 [2-(lH-Indol-4-ylsulfanyl)-benzyl]-methyI-amine
139 [2-(lH-Indol-6-ylsulfanyl)-benzyl]-methy]-amine
140 [2-(lH-Indol-7-ylsulfanyl)-benzyl]-methyl-amine
as the free base or a salt thereof, such as a pharmaceutical^ acceptable salt.
An non limiting aspect of the invention concerns such compounds according to the below embodiments 1-87:
1. A compound represented by the general formulas IA to IF;


Wherein
- R -R" are independently selected from hydrogen, Ci-6-alk(en/yn)yl,
C3.8-cycloalk(en)yls and C3-8-cycloalk(en)yl-Ci.6-alk(en/yn)yl; or R1 and R2
together with the nitrogen form a 4-7 membered ring containing zero or one
double bond, optionally said ring in addition to said nitrogen comprises one
further heteroatom selected from nitrogen, oxygen and sulphur;
- R3-R12 are independently selected from hydrogen, halogen, cyano, nitro,
Ci-6-alk(en/yn)yl, C3-s-cycloalk(en)yl, C3-8-cycloalk(Cn)yl-C-16-allken/yn)yl,

amino, C].6-alk(en/yn)ylamino, di-(Ci-6-alk(en/yn)yl)amino, Ci.6-alk(en/yn)ylcarbonyl, aminocarbonyl, Ci-6-alk(en/yn)ylaminocarbonyl, di-(Ci.6-alk(en)yl)aminocarbonyl, hydroxy, Ci_6-alk(en/yn)yloxy, Ci-6-alk(en/yn)ylthio, halo-Ci_6-alk(en/yn)yl, halo-Ci-6-alk(en/yn)ylsulfonyls halo-Cu6-alk(en/yn)ylsulfanyl5 and Ci-6-alk(en/yn)ylsulfonyl; and
- R13 is selected from hydrogen, Ci_6-alk(en/yn)yl, C3.g-cycloalk(en)yl, and C3.g-cycloalk(en)yl-Ci-6-alk(en/yn)yl;
or a salt thereof.
2. The compound of embodiment 1, wherein R!-R2 are independently selected from hydrogen, Ci-6-alk(en/yn)yl, C3.8-cycloalk(en)yl, and C3-8-cycloalk(en)yl-Ci-6-alk(en/yn)yl; or a salt thereof.
3. The compound of embodiment 1, wherein R!-R2 are independently selected from hydrogen and Ci-e-alkyl; or a salt thereof.
4. The compound of embodiment 1, wherein R is hydrogen and R" is methyl; or a salt thereof.
5. The compound of embodiment 1, wherein R1 and R2 are methyl; or a salt thereof.
6. The compound of embodiment 1, wherein R1 and R2 are hydrogen; or a salt thereof.
7. The compound of embodiment 1, wherein R and R together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur; or a salt thereof.
8. The compound of embodiment 1, wherein R and R together with the nitrogen form a ring selected from the group consisting of azetidine, pyrolidine, piperidine, piperazine, homopiperazine or morpholine; or a salt thereof.
9. The compound of any of embodiments 1-8, wherein R3-R12 are independently selected from hydrogen, halogen, cyano, Ci-g-alkyl, C3.s-cycloalkyl, C3.g-cycloalkyl« Ci.6-alkyl, amino, Ci-e-alkylamino, di-(Ci.6-alkyl)amino? C^e-alkylcarbonyl, aminocarbonyl, Cue-alkylaminocarbonyl, di-(Ci-6-alkylamino)carbonyl, hydroxy, Ci_6-alkoxy, Ci-6-alkylthio, halo-Ci-e-alkyl, halo-Cj.e-alkylsuIfonyl, halo-Ci-6-alkylsulfanyl, and Ci-e-alkylsulfonyl; or a salt thereof.
10. The compound of any of embodiments 1-8, wherein R -R are independently selected from hydrogen, halogen, cyano, nitro, Ci-6-alk(en/yn)yl5 C3.8-cycloalk(en)yl, C3-8-cycloalk(en)yl-Ci.6-alk(en/yn)yl, amino,

Ci-6-alk(en/yn)ylamino, di-(Ci-6-alk(eii/yn)yl)amino, Ci.6-alk(en/yn)ylcarbonyl,
aminocarbonyl, Ci.6-alk(en/yn)ylaminocarbonyls di-(Ci-6-alk(en)yl)aminocarbonyl,
hydroxy, Ci_6-alk(en/yn)yloxy, Ci-6-alk(en/yn)ylthio, halo-Ci.6-alk(en/yn)yl, halo-
Ci-6-alk(en/yn)ylsulfonyl, halo-Ci.6-alk(en/yn)ylsulfanyl, and
Ci-6-alk(en/yn)ylsulfonyl; or a salt thereof. . The compound of any of embodiments 1-8, wherein R3-Rb are independently
selected from hydrogen, halogen, cyano, Cj-6-alkyl, Cs-g-cycloalkyl, C3.g-cycloalkyl-
C-i-6-alkyl, amino, Ci-e-alkylarnino, di-(Ci-6-alkyl)amino, Ci-e-alkyicarbonyl,
aminocarbonyl, Ci-g-alkylaminocarbonyl, di-(Ci.e-alkylamino)carbonyl, hydroxy,
Ci-e-alkoxy, Ci_6-alkylthio, halo-Ci-6-alkyl, halo-Ci-e-alkylsulfonyl, halo-
Ci-e-alkylsulfanyl, and Ci-e-alkylsulfonyl; or a salt thereof. . The compound of any of embodiments 1-8, wherein R3-R6 are independently
selected from hydrogen, halogen, C-i-s-alkyloxy and Ci-e-alkyl; or a salt thereof. , The compound of any of embodiments 1-8, wherein R3-R6 are independently
selected from hydrogen, halogen, methoxy and methyl; or a salt thereof. . The compound of any of embodiments 1-13, wherein only one or two of R3-R6 is
different from hydrogen. , The compound of any of embodiments 1-13, wherein only one of R3-R6 is different
from hydrogen; or a salt thereof. . The compound of any of embodiments 1-9, wherein three of R -R are hydrogen and
one of R3-R6 is halogen; or a salt thereof. . The compound of any of embodiments 1 -9, wherein three of R3-Rb are hydrogen and
one of R3-R6 is methyl; or a salt thereof. . The compound of any of embodiments 15-17. wherein R4 is different from
hydrogen; or a salt thereof. . The compound of any of embodiments 15-17, wherein R5 is different from
hydrogen; or a salt thereof. . The compound of any of embodiments 1-9, wherein R3-R6 are hydrogen; or a salt
thereof. . The compound of any of embodiments 1-20, wherein R13 is hydrogen; or a salt
thereof. . The compound of any of embodiments 1-20, wherein R13 is Ci-e-alkyl; or a salt
thereof

. The compound of any of embodiments 1-20, wherein R13 is methyl; or a salt thereof. ■. The compound of any of embodiments 1-23, wherein the compound has the formula IA; or a salt thereof.
, The compound of any of embodiments 1-23, wherein the compound has the formula IB; or a salt thereof. . The compound of any of embodiments 1-23, wherein the compound has the formula IC; or a salt thereof.
. The compound of any of embodiments 1-23, wherein the compound has the formula ID; or a salt thereof.
, The compound of any of embodiments 1-23, wherein the compound has the formula IE; or a salt thereof.
The compound of any of embodiments 1-23, wherein the compound has the formula IF, or a salt thereof.
The compound of any of embodiments 1-23, wherein the compound has the formula IA and R7 is selected from the group consisting of hydrogen, halogen, cyano, nitro, Ci_6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3.s-cycloalk(en)yl-Ci.6-alk(en/yn)yl, amino. Ci-6-alk(en/yn)ylamino, di-(Ci-6-alk(en/yn)yl)amino, Ci.6-alk(en/yn)ylcarbonyl, aminocarbonyl. Ci.6-alk(en/yn)ylaminocarbonyl, di-(Ci-6-alk(en)yl)aminocarbonyl, hydroxy, Ci_6-alk(en/yn)yloxy, Ci-6-alk(en/yn)ylthio, halo-Ci-6-alk(en/yn)yl, halo-Ci.6»alk(en/yn)ylsulfonyl, halo-Ci-6-alk(en/yn)ylsulfanyl, and Ci-6-alk(en/yn)ylsulfonyl; or a salt thereof.
The compound of any of embodiments 1-23, wherein the compound has the formula IA and R7 is selected from the group consisting of hydrogen, halogen, cyano, Cj.e-alkyl, C3.g-cycloalkyl, C3.s-cycloalkyl-Ci.6-alk}df amino, Ci-6-alkylamino, di-(Ci-6-alkyl)amino, Ci-e-alkylcarbonyl, aminocarbonyl, Ci-6-alkylaminocarbonyl, di-(Ci-6-alkylamino)carbonyl, hydroxy, Cj-6-alkoxy, C-i-6-alkylthio, halo-Ci-6-alkyl, halo-Ci.g-alkylsulfonyl, halo-Ci^-alkylsulfanyl, and Ci-6-alkylsulfonyl; or a salt thereof.
The compound of any of embodiments 1-23, wherein the compound has the formula [A and R7 is hydrogen; or a salt thereof,
The compound of any of embodiments 1-23, wherein the compound has the formula IA and R7 is methyl; or a salt thereof.

The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8-Rn are independently selected from
hydrogen, halogen, cyano, nitro, Ci_6-alk(en/yn)yl, C3.8-cycloalk(en)yl,
C3.g-cycloalk(en)yl-Ci-6-alk(en/yn)yl, amino, Ci-6-alk(en/yn)ylamino,
di-(Ci-6-alk(en/yn)yl)amino, Ci.6-alk(en/yn)ylcarbonyl., aminocarbonyl,
Ci-6-alk(en/yn)ylaminocarbonyl, di-(Ci.6-alk(en)yl)aminocarbonyl, hydroxy,
Ci-6-alk(en/yn)yloxy. Ci_6-alk(en/yn)ylthio, halo-Ci-6-alk(en/yn)yl, halo-
Ci-6-alk(en/yn)ylsulfonyls halo-Ci.6-alk(en/yn)ylsulfanyl, and
Ci.fi-alk(en/yn)ylsulfonyl; or a salt thereof
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8-Rn are independently selected from
hydrogen, halogen, cyano, Ci.e-alkyl, C3-B-cycloalkyl, C3-8-cycloalkyl-Ci.6~alkyl,
amino, Ci.6-alkylamino, di-(Ci-6-alkyl)amino, Ci.e-alkylcarbonyl, aminocarbonyl,
Ci-e-alkylaminocarbonyl, di-(Ci.6-alkylamino)carbonyl, hydroxy, Ci_6-alkoxy5
Ci-6-alkylthio, halo-Ci-e^alkyl, halo-Ci.e-alkylsulfonyl, halo-Ci.6-alkylsulfanyl, and
Ci-e-alkylsulfonyl; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8-Ru are independently selected from
hydrogen, halogen, cyano, methyl, hydroxy, methoxy and trifluoromethyl; or a salt
thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8-Rn are independently selected from
hydrogen, halogen, methyl and methoxy; or a salt thereof.
The compound of any of embodiments 34-36, wherein only one of R8-Rn is
different from hydrogen while rest of R8-Rn are hydrogen; or a salt thereof.
The compound of any of embodiments 34-36, wherein the compound has the
formula IA and two of R8"11 are different from hydrogen and two of R8*11 are
hydrogen; or a salt thereof.
The compound of any one of embodiments 1-23 or 30-37, wherein the compound
has the formula IA and R8 is selected from the group consisting of halogen, methyl,
and methoxy; or a salt thereof.
The compound of embodiments 40, wherein R9"11 are hydrogen; or a salt thereof.
The compound of embodiments 41, wherein R is hydrogen; or a salt thereof.

The compound of any one of embodiments .1-23 or 30-37, wherein the compound
has the formula IA and R9 is selected from the group consisting of halogen, methyl,
and methoxy; or a salt thereof
The compound of embodiments 435 wherein Rs and R10'11 are hydrogen; or a salt
thereof.
The compound of embodiments 44, wherein R7 is hydrogen; or a salt thereof
The compound of any of embodiments 1-23 or 30-33, wherein the compound has the
formula IA and wherein R8'11 are hydrogen; or a salt thereof.
The compound of embodiments 38 or 39, wherein substituent(s) of R8"11 being
different from hydrogen is/are selected from the group consisting of halogen.
methyl, methoxy, hydroxy, cyano; or a salt thereof.
The compound of embodiment 1, wherein the compound has the formula I A, and
- R1 is hydrogen and R2 is hydrogen or a Ci-e-alkyl;
- R -R are independently selected from hydrogen, halogen and methyl, wherein at most one or two of R3-R6 are different from hydrogen;
- R7 is hydrogen or methyl
- R8"11 are independently selected from hydrogen, halogen, methyl, and methoxy wherein at most one or two of R8-Rn are different from hydrogen;
- R13 is hydrogen,
or a salt thereof.
The compound of embodiment 1 wherein the compound has the formula IA,
- R1 is hydrogen and R2 is methyl;
- R3-R6 are as defined in any one of claims 13-20;
- R7 is hydrogen
- R8-Rn are as defined in claim 36-47
- R13 is hydrogen; or a salt thereof.
The compound of any of embodiments 1 -23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8 is hydroxy; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8 is methoxy; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8 is methyl; or a salt thereof.

The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8 is cyano; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8 is CI; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R8 is F; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R9 is cyano; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R9 is F; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R9 is CI; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R9 is Br; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R9 is I; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R9 is methoxy; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R' is methyl; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R9 is hydroxy; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R10 is F; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R10 is CI; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R10 is Br; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R10 is methyl; or a salt thereof.
The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R10 is cyano; or a salt thereof.

, The compound of any of embodiments 1-23, or any of embodiments 30-33, wherein
the compound has the formula 1A and R10 is CF3; or a salt thereof. . The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R10 is methoxy; or a salt thereof. . The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R11 is methyl; or a salt thereof. . The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and Rn is ethyl; or a salt thereof. . The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R11 is methoxy; or a salt thereof. . The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R1l is CI; or a salt thereof. , The compound of any of embodiments 1-23 or any of embodiments 30-339 wherein
the compound has the formula IA and Ru is F; or a salt thereof. , The compound of any of embodiments 50-75, wherein the rest of R8 to R11 are
hydrogen; or a salt thereof. . The compound of any of embodiments 1-23 or any of embodiments 30-33, wherein
the compound has the formula IA and R10 and Ru are selected independently from
the group consisting of hydrogen, methyl, fluoro and chloride; or a salt thereof. . The compound of embodiment 77, wherein at least one of R10 and R11 is hydrogen;
or a salt thereof. , The compound of claim 1 selected from the group consisting of:
[2-(l#-Indol-3-ylsulfanyl)benzyl] dimethyl amine;
[2-(5-C3'ano-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
[2-(4-Fluoro-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
[2-(4-Chloro-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
[2-(5-Fluoro-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
[2-(5-Chloro-lif-indol-3-ylsulfanyl)benzyl] dimethyl amine
Dimethyl-[2-(7-methyl-li/-indol-3-ylsulfanyl)benzyl] amine
[2-(7-Methoxy-liif-indol-3-ylsulfanyl)benzyl] dimethyl amine
[2-(5-Methoxy-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine [2-(6-Fluoro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine [2-(6-Chloro-lJy-mdol-S-ylsulfany^benzyl] dimethyl amine

Dimethyl-[2-(2-methyl-li?-indol-3-ylsulfanyl)benzyl] amine Dimethyl-[2-(6-methyl-lH-indol-3-ylsuIfanyl)benzyl] amine [2-(4-cyano-li7-indol-3-ylsulfanyl)benzyl] dimethyl amine Dimethyl-[2-(l-methyl-lH-mdol-3«ylsulfanyl)benzyl] amine Dimethyl-[2-(4-methyl-lif-indol-3-ylsulfanyl)beiizyI] amine Dimethyl-[2-(4-hydroxy-lH#-indol-3-ylsulfanyl)benzyl] amine [2-(6-cyano-liWndol-3-ylsulfanyl)benzyl] dimethyl amine [2-(7-Chloro-l/y-indol-3-ylsulfanyl)benzyl] dimethyl amine [2-(6-Methoxy-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine [2-(4-Methoxy-li/-indol-3-ylsulfanyI)benzyl] dimethyl amine [2-(lH-Indol-3-ylsulfanyl)benzyl]methylamine [2-(6-Fluoro-li:f-indolo-ylsulfanyl)ben2yl]methyl amine [2-(5-Fluoro-lif-indol-3-ylsulfanyl)benzyl]methyl amine Methyl-[2-(4-methyl-lF-indol-3-ylsulfanyl)benzyl] amine [2-(4-Chloro- l#-indol-3-ylsulfanyl)benzyl]methyl amine Methyl-[2-(2-methyl-l//-indol-3-ylsulfanyl)benzyl] amine [2-(5-Fluoro-2-methyl-lH-indol-3-ylsulfanyl)-benzyl]methyl amine Methyl-[2-(5-methyl-lif-indol-3-ylsulfanyl)benzyl] amine Methyl-[2-(7-methyl-li?-indol-3-ylsulfanyl)benzyl3 amine [2-(4-Fluoro-17/-indol-3-ylsulfanyl)benzyl]methyl amine [2-(7-Ethyl-l#-indol-3-ylsulfanyl)benzyl]methyl amine [2-(6-Methoxy-l#-indol-3~ylsulfanyl)benzyl]methyl amine [2-(5-Chloro- l#-indol-3-ylsulfanyl)benzyl]methyl amine [2-(6-Chloro-lif-indol-3-ylsulfanyl)benzyl]methyl amine [2-(5-Methoxy-4-methyl-lH-indol-3-ylsulfanyl)-benzyl]methyl amine [2-(5,6"Dimethoxy-lH-indol-3-ylsulfanyl)-benzyl]methyl amine [2-(6-Bromo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine Methyl-[2-(6-methyl-lH-indol-3-ylsulfanyl)-benzyl] amine [2-(4,7-Dimethoxy-lH-indol"3-ylsulfanyl)-benzyl]methyl amine [2-(5-Methoxy-l//-indol«3-ylsulfanyl)benzyl]methyl amine [2-(4«Methoxy-li:/-mdol-3-ylsulfanyI)benzyl]methyl amine [2-(5-Bromo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine [2-(7-Methoxy-liy-indol-3-ylsulfanyl)benzyl]methyl amine

[5-Chloro-2-(7if-indol-3-ylsulfanyl)-benzyl]methyl amine
Methyl-[2-(6-trifluoromethyl-7i7-indol-3-ylsulfanyl)-benzyl] amine;
[5-Hydroxy-2-(iif-indol-3-ylsulfanyl)-benzyl]methyl amine;
[2-(4-Bromo-7/f-indol-3-ylsulfanyl)-benzyl]methyl amine;
[2-(7-Chloro-//f-indol-3-ylsulfanyl)-benzyl]methyl amine;
[2-(5-Iodo-iif-indol-3-ylsulfanyl)-benzyl]methyl amine;
[2-(6-Cyano-/if-indol-3-ylsulfanyl)-benzyl]methyl amine;
[2-(/#-Indol-3-ylsulfanyl)-5-methyl-benzyl]methyl amine;
[2-(3 -methyl-7#4ndol-2-ylsulfanyl)-benzyl]methyl amine;
[2-(5,6-Dimethoxy-l/f-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine;
[5-Fluoro-2-(3-methyl-li?-indol-2-ylsulfanyl)-benzyl]-methyl-amine;
[5-Fluoro-2-(4-fluoro-l^-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[2-(4«Chloro-li7-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine;
[2-(7-Cliloro-17/-indol-3-ylsulfanyl)-5-fluoro«benzyI]-methyl-amine;
[5-Fluoro-2-(6-trifluoromethyl-17y-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Fluoro-2-(7-methoxy-lif-indol-3-ylsulfanyl)-ben2yl]-methyl-ainine;
[2-(4-Bromo-li¥-indol-3-ylsulfanyl)-5-fluoro-ben2yl]-methyl-amine;
3-(4-Fluoro-2-methylaminomethyl-phenylsulfanyl)-2-methyl-li/-indol-4-ol;
3-(4-Fluoro-2-methylaminomethyl»phenylsulfanyl)-17f-indol-6-ol;
[5-Fluoro-2-(5-fluoro-177-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Fluoro-2-(4-methoxy-ljff-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[2-(6-Chloro-li7*-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine;
[2-(5-Chloro-lif-indol-3-ylsulfanyl)-5-fluoro-ben2yl]-methyl-amine;
[5-Fluoro-2-(6-methyl-l//-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Fluoro-2-(5-methoxy-4-methyl-17?-indol-3«ylsulfanyl)-benzyl]-methyl-amine;
[2-(5-Bromo*17/-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine;
[S-Fluoro^^S-methoxy-lTT'-indol-S-ylsulfany^-benzylJ-methyl-amine;
[2-(6-Bromo-l/^-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine;
[5-Fluoro-2-(6-fluoro-l//-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Fluoro-2-(6-methoxy-lif-indol-3-ylsulfanyl)-benzyl]-methyl-ainine;
[5-Fluoro-2-(2-methyl-l/f-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Fluoro-2-(5»methyl-17/-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Fluoro-2-(4-methyl-li7-indol-3-ylsulfanyl)-benzyl]-methyl-amine;

[5-Fluoro-2-(7-methyl-lH-in^^
[5-Fluoro-2-(l-methyMH-indol-3-ylsu^
[5-Fluoro-2-(5-fluoro-2-methyl-lif-indol-3-ylsulfanyl)-ben2yl]-methyl-amin^
[5-Chloro-2-(5-fluoro4if-indol-3-ylsulfanyl)-benzyI]-methyl«amiiie;
[5-Chloro-2-(5-methoxy-lif4ndol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Chloro-2-(7-methyl-lif-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Chloro-2-(l-me1hyl-lif-indol-3-ylsulfanyl)-benzyl]-methyl-am
[5-Chloro-2-(4-methoxy4i?-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[5-Chloro-2-(7-methoxy-lJ7-indol-3-ylsulfanyl)-benzyl]-methyl-aniine;
[5-Chloro-2-(6-fluoro-li/-indol-3-ylsulfanyl)-ben2yl]-methyl-aniine;
[5-Chloro-2-(5-fluoro-2-methyl4i/-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
[2-(5iFluoro-2-methyl4if-indol-3-ylsulfanyl)-5-methyl"benzyl]-methyl-am
Methyl-[5-meth}4-2-(4-methyl47?4ndol-3»ylsulfanyl)-benzyl]-amine;
[2-(7-Ethyl-li7-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine;
[2-(6-Methoxy-li^4ndolO-ylsulfanyl)-5-methyl-benzyl]-methyl-arnine;
Methyl-[5-methyl-2-(2»methyl4if-indol-3-ylsulfanyl)-benzyl]-amine;
[2-(4-Methoxy-l/y-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine;
[2-(6-Bromo-lif-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine;
[2-(6-Fluoro-liy-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine;
[2-(4-Fluoro-li?-indol-3-ylsulfanyI)-5-methyl-benzyl]-methyl-amine;
3-(4-Methyl-2-methylaminomethyl-phenylsulfaayl)-li/-indoI-6-ol;
[5-ChIoro-2-(5-methyl-li/-indol-3-ylsulfanyl)-beiizyl]-methyl-amine;
[2-(6-Chloro-lif-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine;
[2-(5-Chloro-li?-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine;
5-Fluoro-3-(2-piperidin-l-ylmethyl-phenylsulfanyl)-li?-indole;
5-Fluoro-3-(2«morpholin-4-ylmethyl-phenylsulfanyl)-lif-indole;
5-Fluoro-3-(2-pyrrolidin-l-ylmethyl-phenylsulfanyl)-li/-indole;
[4-Chloro-2-(6-methyl-liy-indol-3-ylsulfanyl)-ben2yl]-methyl-amine;
[4-Chloro-2-(2 [4-Chloro-2-(5-methyl-li?-indol-3-ylsulfanyl)-benzyl]-methyl-aiTiine;
[4-Chloro-2-(7-methyl4i?-indol-3-ylsulfanyl)-benzyl]-methyl-am
[4-ChIoro-2-(4-methyl-l/f-indol-3-ylsulfanyl)-benzyl]-metliyl-amm
[4-Chloro-2-(5-fluoro^/f"indol-3-ylsulfanyl)-benzyl]-methyl-amine;

[4-Chloro-2-(6-fluoro4iir-indol-3-ylsuIfanyl)Tbenzyl]-methyl-amine; [4-Chloro-2-(4-fluoro-li?-indol-3-ylsulfanyl)-beii2yl]-methyl-amine; [4-Chloro-2-(7-fluoro-li/-indol-3-ylsulfanyl)-ben2yl]-methyl-amine; [4-CWoro-2-(7-ethyl-17y-indol-3-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(5-methoxy-4-methyl-lif-indol-3-ylsulfanyl)-benzyl]-methyl-amin^ [4-CUoro-2-(5-methoxy-li/-indol-3-ylsulfanyl)-beri2yl]-methyl-amine; [4-Chloro-2-(6-methoxy-lii/-indolO-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(7-methoxy-li?-indol-3-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(4-methoxy4if-indolO-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(5-ohloro-li7-indol-3-ylsulfanyl)-ben2yI]-methyl-ainine; [4-Chloro-2-(6-chloro-liy-indol-3-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(4-chloro-ljFf-indol-3-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(7-chloro-lif-indol-3-ylsulfanyl)-benzyl]-methyl-aniine; [4-Chloro-2-(lif-indol-3-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(l-methyl-l/f-indol-3-ylsulfanyl)-benzyl]-methyl-amine; [4-Chloro-2-(3-methyl4i^-indol-2-34sulfanyl)-beiizyl]-methyl-aniine; [4-Chloro-2-(5-fluoro-2-methyl4i7-indol-3-ylsulfanyl)-benzyl]-methyl-amine; 2-(5-Fluoro-lH-indol-3-ylsulfanyl)-benzylamine; [2-(5-Fluoro-4-methoxy-li7-indol-3-ylsulfanyl)-ben2yl]-methyl-amine; [2-(4,5-Difluoro-li7-indol-3-ylsulfanyl)-benzyl]-methyl"amine; [2-(456-Difluoro-l^-indol-3-ylsulfanyl)-benzyl]-methyl-amine; 3-(2-Methylaminomethyl-phenylsulfanyl)-li?-indol-4-ol; 2-(6-Fluoro-li/-indol-3-ylsulfanyl)-benzylamine; [2-(5,6-Difluoro-l/f-indol-3-ylsulfanyl)-benzyl]-methyl-amine; 6-Fluoro-3-(2-methylaminomethyl-pta^ indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine; [2-(lH-Indol-5-ylsulfanyl)-benzyl]-methyl-amine; [2-(lH-Indol-4-ylsulfanyl)-benzyl]-methyl-amine; [2-(lH-Iiidol-6-ylsulfanyl)-benzyl]-methyl-amine; and [2-(lH-Indol-7-ylsulfanyl)-benzyl]-methyl-amine; or a salt thereof, 80. The compound of any of embodiments 1-23, wherein the compound has the formula IB and R12 is hydrogen or methyl; or a salt thereof.

. A compound of any one of embodiments 1-80 or a pharmaceutically acceptable salt thereof for use in a medicament.
. The use of a compound of any one of embodiments 1-80 or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment of affective disorders.
, The use of a compound of any one of embodiments 1-80 or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment of depression, anxiety disorders including general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia or agoraphobia. The use of a compound of any one of embodiments 1-80 or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment of depression.
A method for the treatment of an affective disorder comprising administering a therapeutically effective amount of a compound of any one of embodiments 1-80 or a pharmaceutically acceptable salt thereof.
A method for the treatment of depression, anxiety disorders including general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia or agoraphobia comprising administering a therapeutically effective amount of a compound of any one of embodiments 1 -80 or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of any one of embodiments 1-80 or a pharmaceutically acceptable salt thereof.
The present invention comprises the free bases of the compounds of the invention. The present invention furthermore comprises salts of the compounds of the invention, typically, pharmaceutically acceptable salts. Such salts include pharmaceutical acceptable acid addition salts, pharmaceutically acceptable metal salts, ammonium and alkylated ammonium salts. Acid addition salts include salts of inorganic acids as well as organic acids.

Examples of suitable inorganic acids include hydrochloric, hydrobromic, hydroiodic, phosphoric, sulfuric, sulfamic, nitric acids and the like.
Examples of suitable organic acids include formic, acetics trichloroacetic, trifluoroacetic, propionic, benzoic, cinnamic, citric, fumaric, glycolic, itaconic, lactic, methanesulfonic, maleic, malic, malonic, mandelic, oxalic, picric, pyruvic, salicylic, succinic, methane sulfonic, ethanesulfonic, tartaric, ascorbic, pamoic, bismethylene salicylic, ethanedisulfonic, gluconic, citraconic, aspartic, stearic, palmitic, EDTA, glycolic, p-aminobenzoic, glutamic, benzenesulfonic, p-toluenesulfonic acids, theophylline acetic acids, as well as the 8-halotheophyllines, for example 8-bromotheophylline and the like.
Also intended as pharmaceutical acceptable acid addition salts are the hydrates, which the present compounds, are able to form.
Further, the compounds of this invention may exist in unsolvated as well as in solvated forms with pharmaceutical^ acceptable solvents such as water, ethanol and the like. In general, the solvated forms are considered equivalent to the unsolvated forms for the purposes of this invention.
The compounds of the present invention may have one or more asymmetric centres and it is intended that any optical isomers (i.e, enantiomers or diastereomers), as separated, pure or partially purified optical isomers and any mixtures thereof including racemic mixtures, i.e. a mixture of stereoisomeres, are included within the scope of the invention
Racemic forms can be resolved into the optical antipodes by known methods, for example, by separation of diastereomeric salts thereof with an optically active acid, and liberating the optically active amine compound by treatment with a base. Another method for resolving racemates into the optical antipodes is based upon chromatography on an optically active matrix. Racemic compounds of the present invention can also be resolved into their optical antipodes, e.g. by fractional crystallization. The compounds of the present invention may also be resolved by the formation of diastereomeric derivatives. Additional methods for the resolution of optical isomers, known to those skilled in the art, may be used. Such methods include those discussed by J. Jaques, A. Collet and S. Wilen in "Enantiomers, Racemates.

and Resolutions", John Wiley and Sons, New York (1981). Optically active compounds can also be prepared from optically active starting materials.
Furthermore, when a double bond or a fully or partially saturated ring system is present in I the molecule geometric isomers may be formed. It is intended that any geometric isomers, as separated, pure or partially purified geometric isomers or mixtures thereof are included within the scope of the invention. Likewise, molecules having a bond with restricted rotation may form geometric isomers. These are also intended to be included within the scope of the present invention. i
Furthermore, some of the compounds of the present invention may exist in different tautomeric forms and it is intended that any tautomeric forms that the compounds are able to form are included within the scope of the present invention.
The invention also encompasses prodrugs of the present compounds, which on administration undergo chemical conversion by metabolic processes before becoming pharmacologically active substances. In general, such prodrugs will be functional derivatives of the compounds of the general formula I, I A, IB, IC, IE or IF which are readily convertible in vivo into the required compound of the formula I, IA, IB, IC, IE or IF. Conventional procedures for the selection and preparation of suitable prodrug derivatives are described, for example, in"Design of Prodrugs", ed. H. Bundgaard, Elsevier, 1985.
The invention also encompasses active metabolites of the present compounds.
As described above the compounds of the invention, 2-(lH-indolylsulfanyl)-benzyl amine derivatives, are serotonin reuptake inhibitors.
Accordingly, one embodiment of invention relates to compounds of Formula I, IA, IB, IC, IE or IF (e.g. formula IA) as the free base or a salt therof, wherein R*-R13 are as described herein, which compounds are serotonin reuptake inhibitors, i.e., e.g.. having a binding affinity (IC50) of 5 (iM or less, typically of 1 p.M or less, preferably less than 500nM or less than 100 nM or less than 50 nM, preferably as measured by the method described in Example 9 - Transporter binding assay.

One embodiment of invention relates to compounds of formula I, IA, IB, IC, IE or IF (e.g. formula IA) as the free base or salts therof, wherein R!-R13 are as described herein, which compounds are norepinephrine reuptake inhibitors, i.e., e.g., having a binding affinity (IC50) of 5 \xM or less, typically of 1 fiM or less, preferably less than 500nM, less than 100 nM or less than 50 nM, preferably as measured by the method described in Example 9 -Transporter binding assay.
A further embodiment of invention relates to compounds of formula I, IA, 13, IC. IE or IF (e.g. formula (IA)) as the free base or salts thereof, wherein R -R are as described herein, which compounds are dopamine reuptake inhibitors, i.e., e.g., having a binding affinity (IC50) of 5 |iM or less, typically of 1 |iM or less, preferably less than 500nM, less than 100 nM or less than 50 nM, preferably as measured by the method described in Example 9 -Transporter binding assay.
In particular, the invention provides compounds possessing the combined effect of serotonin reuptake inhibition and norepinephrine reuptake inhibition. Accordingly, a preferred embodiment relates to compounds of the invention (i.e. the compounds of formula I, IA, IB, IC, IE or IF (e.g. of formula IA) for which R2-R13 are as described herein) being dual serotonin and norepinephrine reuptake inhibitors, i.e. compounds of the invention which are both norepinephrine reuptake inhibitors and serotonin reuptake inhibitors, each of which are as defined above.
In one embodiment, it is preferred for the compounds of the invention possessing the combined effect of serotonin reuptake inhibition and norepinephrine reuptake inhibition as described above, that such compounds are not also dopamine reuptake inhibitors. Thus, this embodiment relates to compounds of the invention having a binding affinity for the serotonin transporter which is at least 5, preferably at least 10 or even more preferred at least 20 or 30 times higher than the binding affinity for the dopamine transporter, preferably as measured by the methods described in Example 9 - Transporter binding assay.
In a further aspect the invention provides compounds possessing the combined effect of serotonin reuptake inhibition, norepinephrine and dopamine reuptake inhibition.

Accordingly, a preferred embodiment relates to compounds of the invention (i.e. the compounds of formula I, IA, IB, IC, IE or IF (e.g. formula IA) for which Rl-R13 are as described herein) being triple serotonin, norepinephrine and dopamine reuptake inhibitors, i.e. compounds of the invention which are at the same time norepinephrine reuptake inhibitors, serotonin reuptake inhibitors, and dopamine reuptake inhibitors, each of which are as defined above,
Pharmaceutical use
In a further aspect the invention provides a compound of formula I, IA, IB. IC, ID, IE or IF for use as a medicament.
As mentioned above the compounds of the invention are inhibitors of the serotonin transporter. In particular is provided compounds of the invention which are dual inhibitors of the serotonin and noradrenaline transporters. The compounds of the invention may thus be useful for treatment in a disorder or disease wherein the serotonin and/or noradrenaline are implicated.
Accordingly, in a further aspect the invention relates to a compound of the, invention as the free base or a salt thereof for use as a medicament, i.e. in particular a compound represented by the general formula I, IA, IB, IC, IE or IF, e.g. formula IA, wherein - R*-R2 are independently selected from hydrogen, Ci-6-alk(en/yn)yl, C3.g-cycloalk(en)yl, and C3.8-cycloalk(en)yl-Ci.6-alk(en/yn)yl; or R and R" together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur; which ring structure is substituted or unsubstituted as described herein;
are independently selected from hydrogen, halogen, cyano, nitro, Ci-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3.8-cycloalk(en)yl-Ci-e-alk(en/yn)yl, amino, Ci.6-alk(en/yn)ylamino5 di-(Ci-6-alk(en/yn)yl)amino, Ci.6-alk(en/yn)ylcarbonyl, aminocarbonyl, Ci-6-alk(en/yn)ylaminocarbonyl, di-(Ci.6-alk(en)yl)aminocarbonyl, hydroxy, Ci_6-alk(en/yn)yloxy, Ci_6-alk(en/yn)ylthio, halo-Ci.6-alk(en/yn)yl, halo-Ci-6-alk(en/yn)ylsulfonyl, halo-Ci.6-alk(en/yn)ylsulfanyl, and Ci-6-alk(en/yn)ylsulfonyl; and

- R13 is selected from hydrogen, Ci-6-alk(en/yn)yl, C-3.g-cycloalk(en)ylJ and
C3-8-cycloalk(en)yl-Ci.6-alk(en/yn)yl;
as the free base or a salt thereof; with the provisos that: ' - when the sulphur atom is attached via atom nr. 2 of the indole then R does not exist;
- when the sulphur atom is attached via atom nr. 3 of the indole then R12 does not exist;
- when the sulphur atom is attached via atom nr. 4 of the indole then R8 does not exist;
- when the sulphur atom is attached via atom nr. 5 of the indole then R9 does not exist;
- when the sulphur atom is attached via atom nr. 6 of the indole then R10 does not exist; and
- when the sulphur atom is attached via atom nr. 7 of the indole then R11 does not exist,
By the expression a compound of the invention is meant any one of the embodiments of formula I, IA, IB, IC, IE or IF, in particular formula IA described herein.
The present invention also relates to a pharmaceutical composition comprising a compound of the invention as the free base or a salt thereof and a pharmaceutical^ acceptable carrier or diluent.
In an embodiment of the pharmaceutical composition, the compound of the invention is present in an amount of from about 0.001 to about 100 mg/kg body weight per day.
The present invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of a disease or disorder, wherein a serotonin reuptake inhibitor is beneficial. The medicament may comprise any one of the embodiments of formula I, IA, IB, IC, IE or IF described herein.
The present invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of a disease or disorder, wherein the combined effect of serotonin reuptake inhibition and norepinephrine reuptake inhibition is beneficial. The medicament may comprise any one of the embodiments of formula I, IA, IB, IC, IE or IF described herein.

The present invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of a disease or disorder, the combined effect of serotonin reuptake inhibition and norepinephrine ' and dopamine reuptake inhibition is beneficial. The medicament may comprise any one of the embodiments of formula I, IA, IB, IC, IE or IF described herein.
A farther embodiment of the invention relates to the use of a compound of formula L IA, IB, IC, ID, IE or IF for the preparation of a pharmaceutical composition for the treatment of affective disorders, pain disorders, ADHD and stress urinary incontinence.
In particular the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of affective disorders, To further illustrate without limiting the invention, the affective disorder to be treated is selected from the group consisting of depressive disorders and anxiety disorders.
A further embodiment concerns the use of a compound of formula I, IA, IB, IC, ID, IE or IF for the preparation of a pharmaceutical composition for the treatment of depressive disorders. Typically, the depressive disorder to be treated is selected from the group consisting of major depressive disorder, postnatal depression, dysthymia and depression associated with bipolar disorder, alzheimers, psychosis orparkinsons. To further illustrate without limiting the invention, an embodiment of the invention concerns the treatment of major depressive disorder; another embodiment concerns the treatment of postnatal depression; another embodiment concerns the treatment of dysthymia; another embodiment concerns the treatment of depression associated with bipolar disorder, alzheimers, psychosis or parkinsons. To further illustrate without limiting the invention, an embodiment of the invention concerns the treatment of depression associated with bipolar disorder; another embodiment concerns the treatment of depression associated with alzheimers; another embodiment concerns the treatment of depression associated with psychosis; another embodiment concerns the treatment of depression associated with parkinsons.

In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of depression.
In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of anxiety disorders. Typically, the anxiety disorders to be treated are selected from the group consisting of general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia and agoraphobia. In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of general anxiety disorder. In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of social anxiety disorder. In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of post traumatic stress disorder. In a further embodiment the present invention also relates to use of a compound of the invention as the free base or a salt thereof the preparation of a pharmaceutical composition for the treatment of obsessive compulsive disorder. In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of panic disorder. In a further embodiment present invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of panic attacks. In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of specific phobias. In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of social phobia. In a further embodiment the invention also relates to use of a compound of the invention as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of agoraphobia.

A further aspect of the invention relates to a method for the treatment of a disease or disorder selected from the group consisting of an affective disorder, such as depression, anxiety disorders including general anxiety disorder, social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder, panic disorder, panic attacks, specific i phobias, social phobia and agoraphobia in a living animal body, including a human,
comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the invention as the free base or a salt thereof, i.e. in particular a compound represented by the general formula I, IA, IB, IC, IE or IF, e.g. formula IA.
In a further embodiment the present invention relates to the use of a compound of formula I, IA, IB, IC, ID or IE as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of pain disorders. To further illustrate without limiting the invention, the pain disorder to be treated is selected from the group consisting of fibromyalgia syndrome (FMS), overall pain, back pain, shoulder pain, headache as well as pain while awake and during daily activities. To further illustrate without limiting the invention, an embodiment of the invention concerns the treatment of fibromyalgia syndrome; another embodiment concerns the treatment of overall pain; another embodiment concerns the treatment of back pain; another embodiment concerns the treatment of shoulder pain; another embodiment concerns the treatment of headache; another embodiment concerns the treatment of pain while awake and during daily activities.
In a further embodiment the present invention relates to the use of a compound of formula I, IA, IB, IC, ID or IE as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of attention deficit hyperactivity disorder.
In a further embodiment the present invention relates to the use of a compound of formula I, IA, IB, IC, ID or IE as the free base or a salt thereof for the preparation of a pharmaceutical composition for the treatment of stress urinary incontinence.
Pharmaceutical composition
The compounds of the invention as the free base or the salt thereof may be administered . alone or in combination with pharmaceutically acceptable carriers or excipients, in either single or multiple doses. The pharmaceutical compositions according to the invention may

be formulated with pharmaceuticaliy acceptable carriers or diluents as well as any other known adjuvants and excipients in accordance with conventional techniques such as those disclosed in Remington; The Science and Practice of Pharmacy, 19 Edition, Gennaro, Ed., Mack Publishing Co., Easton, PA, 1995.
The pharmaceutical compositions may be specifically formulated for administration by any suitable route such as the oral, rectal, nasal, pulmonary, topical (including buccal and sublingual), transdermal, intracisternal, intraperitoneal, vaginal and parenteral (including subcutaneous, intramuscular, intrathecal, intravenous and intradermal) route, the oral route being preferred. It will be appreciated that the preferred route wall depend on the general condition and age of the subject to be treated, the nature of the condition to be treated and the active ingredient chosen.
Pharmaceutical compositions for oral administration include solid dosage forms such as capsules, tablets, dragees, pills, lozenges, powders and granules. Where appropriate, they can be prepared with coatings such as enteric coatings or they can be formulated so as to provide controlled release of the active ingredient such as sustained or prolonged release according to methods well known in the art.
Liquid dosage forms for oral administration include solutions, emulsions, suspensions, syrups and elixirs.
Pharmaceutical compositions for parenteral administration include sterile aqueous and nonaqueous injectable solutions, dispersions, suspensions or emulsions as well as sterile powders to be reconstituted in sterile injectable solutions or dispersions prior to use. Depot injectable formulations are also contemplated as being within the scope of the present invention.
Other suitable administration forms include suppositories, sprays, ointments, cremes, gels, inhalants, dermal patches, implants, etc.
In an embodiment of the pharmaceutical composition, the compound of the invention administered in an amount of from about 0.001 to about 100 mg/kg body weight per day.

Conveniently, the compounds of the invention are administered in a unit dosage form containing said compounds in an amount of about 0.01 to 100 mg. The total daily dose is usually in the range of about 0.05 - 500 mg.
A typical oral dosage is in the range of from about 0,001 to about 100 mg/kg body weight per day, preferably from about 0.01 to about 50 mg/kg body weight per day, administered in one or more dosages such as 1 to 3 dosages. The exact dosage will depend upon the frequency and mode of administration, the sex, age, weight and general condition of the subject treated, the nature and severity of the condition treated and any concomitant diseases to be treated and other factors evident to those skilled in the art.
The formulations may conveniently be presented in unit dosage form by methods known to those skilled in the art. A typical unit dosage form for oral administration one or more times per day such as 1 to 3 times per day may contain from 0.01 to about 1000 mg, preferably from about 0.05 to about 500 mg, and more preferred from about 0.5 mg to about 200 mg.
For parenteral routes such as intravenous, intrathecal, intramuscular and similar administration, typically doses are in the order of about half the dose employed for oral administration.
The compounds of this invention are generally utilized as the free substance or as a salt such as a pharmaceutical^ acceptable salt thereof. One example is an acid addition salt of a compound having the utility of a free base. When a compound of the invention contains a free base such salts are prepared in a conventional manner by treating a solution or suspension of a free base of the invention with a chemical equivalent of an acid such as a pharmaceutically acceptable acid. Representative examples are mentioned above.
For parenteral administration, solutions of the compound of the invention in sterile aqueous solution, aqueous propylene glycol, aqueous vitamin E or sesame or peanut oil may be employed. Such aqueous solutions should be suitably buffered if necessary and the liquid diluent first rendered isotonic with sufficient saline or glucose. The aqueous solutions are particularly suitable for intravenous, intramuscular, subcutaneous and intraperitoneal

administration. The sterile aqueous media employed are all readily available by standard techniques known to those skilled in the art.
Suitable pharmaceutical carriers include inert solid diluents or fillers, sterile aqueous solution and various organic solvents. Examples of solid carriers are lactose, terra alba, sucrose, cyclodextrin, talc, gelatine, agar, pectin, acacia, magnesium stearate, stearic acid and lower alkyl ethers of cellulose. Examples of liquid carriers are syrup, peanut oil, olive oil, phospho lipids, fatty acids, fatty acid amines, polyoxyethylene and water. Similarly, the carrier or diluent may include any sustained release material known in the art, such as glyceryl monostearate or glyceryl distearate, alone or mixed with a wax. The pharmaceutical compositions formed by combining the compound of the invention and the pharmaceutical acceptable carriers are then readily administered in a variety of dosage forms suitable for the disclosed routes of administration. The formulations may conveniently be presented in unit dosage form by methods known in the art of pharmacy.
Formulations of the present invention suitable for oral administration may be presented as discrete units such as capsules or tablets, each containing a predetermined, amount of the active ingredient, and which may include a suitable excipient. Furthermore, the orally available formulations may be in the form of a powder or granules, a solution or suspension in an aqueous or non-aqueous liquid, or an oil-in-water or water-in-oil liquid emulsion.
If a solid carrier is used for oral administration, the preparation may be tablette. e.g. placed in a hard gelatine capsule in powder or pellet form or e.g. in the form of a troche or lozenge. The amount of solid carrier may vary but will usually be from about 25 mg to about 1 g.
If a liquid carrier is used, the preparation may be in the form of a syrup, emulsion, soft gelatine capsule or sterile injectable liquid such as an aqueous or non-aqueous liquid suspension or solution.
The pharmaceutical formulations of the invention may be prepared by conventional methods in the art.

For example; Tablets may be prepared by mixing the active ingredient with ordinary adjuvants and/or diluents and subsequently compressing the mixture in a conventional tabletting machine. Examples of adjuvants or diluents comprise: Corn starch, potato starch, talcum, magnesium stearate, gelatine, lactose, gums, and the like. Any other adjuvants or additives usually used for such purposes such as colourings, flavourings, preservatives etc. may be used provided that they are compatible with the active ingredients.
Solutions for injections may be prepared by dissolving the active ingredient and possible additives in a part of the solvent for injection, preferably sterile water, adjusting the solution to the desired volume, sterilising the solution and filling it in suitable ampoules or vials. Any suitable additive conventionally used in the art may be added, such as tonicity agents, preservatives, antioxidants, etc.
In a further aspect the present invention relates to a method of preparing a compound of the invention as described in the following.

Methods of preparation of the compounds of the invention
The compounds of the invention may be prepared as follows:
Method 1 (for compounds of formula IA) Alkylating an amine of formula III with an alkylating derivative of formula II:

where R[-R13 are as defined herein, and L is a leaving group such as e.g. halogen, mesylate or tosylate;
whereupon the compound of formula IA is isolated as the free base or a salt such as a pharmaceutical^ acceptable acid addition salt thereof.
Method 2 (for compounds of formula IA) Reduction of an amide derivative of formula IV: where R!-R13 are as defined herein;

whereupon the compound of formula IA is isolated as the .free base or a salt such as a pharmaceutical^ acceptable acid addition salt thereof.
Method 3 (for compounds of formula IA, also for compounds of formula IB when R12 * hydrogen) Reacting an indole of formula V with a reagent of formula VI by the use of a
catalyst:
where R'-R13 are as defined herein;
whereupon the compound of formula IA or the compound of formula IB when R12 * hydrogen is isolated as the free base or a salt such as a pharmaceutical^ acceptable acid addition salt thereof.
Method 4 (for compounds of formula IC) Reduction of an amide derivative of formula VII:

where R*-R13 are as defined herein;
whereupon the compound of formula IC is isolated as the free base or a salt such as a
pharmaceutically acceptable acid addition salt thereof.

Method 5 (for compounds of formula ID) Reduction of an amide derivative of formula VIII:

where R -R are as defined herein;
whereupon the compound of formula ID is isolated as the free base or a salt such as a
pharmaceutically acceptable acid addition.salt thereof.
Method 6 (for compounds of formula IE) Reduction of an amide derivative of formula IX:

where R!-R13 are as defined herein;
whereupon the compound of formula IE is isolated as the free base or a salt such as a
pharmaceutically acceptable acid addition salt thereof.
Method 7 (for compounds of formula IF) Reduction of an amide derivative of formula X:


where R^R13 are as defined herein;
whereupon the compound of formula IF is isolated as the free base or a salt such as a
pharmaceutical^ acceptable acid addition salt thereof.
Method 8 (for compounds of formula IB with R12 = hydrogen) Reduction of an amide derivative of formula XI:

where R]-R13 are as defined herein;
whereupon the compound of formula IB is isolated as the free base or a salt such as a
pharmaceutically acceptable acid addition salt thereof.
Method 9 (for compounds of formula IC with R = hydrogen) Deprotection of a compound of formula XII:

where R1, R3-R13 are as defined herein and R is a protection group such as a carbamate (such as methyl-, ethyl-, te;7-butyl-, allyl-, or benzyl-carhamate); whereupon the compound of formula IC is isolated as the free base or a salt such as a phaimaceutically acceptable acid addition salt thereof.
Method 10 (for compounds of formula ID with R" = hydrogen) Deprotection of a compound of formula XIII:

where R1, R3-R13 are as defined herein and R is a protection group such as a carbamate (such as methyl-, ethyl-, fe/7-butyl-, allyl-, or benzyl-carbamate); whereupon the compound of formula ID is isolated as the free base or a salt such as a phaimaceutically acceptable acid addition salt thereof.
Method 11 (for compounds of formula IE with R2 = hydrogen) Deprotection of a compound
of formula XIV:

where R , R -R are as detined herein and R is a protection group such as a carbamate (such as methyl-, ethyl-, ferf-butyl-, allyl-, or benzyl-carbamate); whereupon the compound of formula IE is isolated as the free base or a salt such as a pharmaceutically acceptable acid addition salt thereof.
Method 12 (for compounds of formula IF with R2 = hydrogen) Deprotection of a compound of formula XV:
where R1, R3-RiJ are as detined herein and R is a protection group such as a carbamate (such as methyl-, ethyl-, tert-butyl-9 allyl-, or benzyl-carbamate); whereupon the compound of formula IF is isolated as the free base or a salt such as a pharmaceutically acceptable acid addition salt thereof.
The alkylation according to method 1 is conveniently performed in an organic solvent such as a suitably boiling alcohol or ketone, preferably in the presence of an organic or inorganic base (potassium carbonate, diisopropylethylamine or triethylamine) at reflux temperature. Alternatively, the alkylation can be performed at a fixed temperature, which is different from the boiling point, in one of the above-mentioned solvents or in dimethyl formamide

(DMF). dimethylsulfoxide (DMSO), orN-methylpyrrolidin-2-one (NMP), preferably in the presence of a base. The alkylating derivatives of formula II can be derived from the corresponding benzylic alcohols which in turn are synthesised from the corresponding benzoic acids by standard reduction methods e.g. by the use of lithium aluminium hydride. The corresponding benzoic acids can be synthesised by methods analogous to those described in e.g. Hamel, P.; Girard, M.; Tsou, N. N.; J.Heterocycl.Chem.; 36,1999, 643 -652. The amines of formula III are commercially available.
The reduction according to method 2 is performed by standard literature methods i.e. by the use of a reducing agent like borane, alane or lithium aluminium hydride. Amides of the formula V can be prepared by coupling of the corresponding benzoic acids (synthesised by methods analogous to those described in e.g. Hamel, P.; Girard, M.; Tsou, N. N.; J.Heterocycl.Chem,; 36,1999, 643-652 and Hamel, P.; Zajac, N.; Atkinson, J. G.; Girard, Y.; J. Org. Chem.; 59; 21; 1994; 6372-6377) with an amine of formula III by standard ■ methods e.g. via the carboxylic acid chloride or activated esters or by the use of carboxylic acids in combination with a coupling reagent such as e.g. dicyclohexyl carbodiimide.
The reaction in method 3 can be performed by reacting a Ar-alkyl-2,3-dihydro-benzo[d]isothiazole of formula VI with an indole of formula V in the presence of an activating agent like e.g. an lewis acid or e.g. an oxidising agent like e.g. N-chlorosuccinimide. A^-Alkyl-2,3-dihydro-benzo[d]isothiazoles of formula VI can be prepared by methods analogous to those described in the literature e.g. Hoffmann, R. W,; Goldmann, S.; ChentBer. Ill, 1978, 2716-2725 andKanakarajan, K.; Meier, H.; Angew.Chem. 96,1984, 220. Indoles of formula V are either commercially available or can be prepared by standard methods as described in standard works like e.g. Houben-Weyl, Methoden der organischen Chemie (Methods of Organic Chemistry), Georg-Thieme-Verlag, Stuttgart and Organic Reactions, John Wiley & Sons, Inc. New York,
The reduction according to method 4 is performed by standard literature methods i.e. by the use of a reducing agent like borane, alane or lithium aluminium hydride. Amides of the formula VII can be prepared by coupling of the corresponding 2-mercapto-benzamides (synthesised by reduction of the corresponding 2,2'-dithiobenzamides analogous to those described in e.g. Elworthy, T. R.; Ford, A. P. D. W.; Bantle, G. W.; Morgans, D. J.; Ozer, R.

S.; et al. J.MedChem. 40,1997, 2674-2687) with a 4-halo- or 4-pseudohaIo indole by methods analogous to those described in the literature e.g. Schopfer, U.; Schlapbach, A. Tetrahedron; 57, 2001, 3069-3073, where "halo" is either bromo or iodo or "pseudohalo" is e.g. triflate or nonaflate. When R13 = hydrogen in formula VII, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a ferf-butoxy-carbonyl group.
The reduction according to method 5 is performed by standard literature methods i.e. by the use of a reducing agent like borane, alane or lithium aluminium hydride. Amides of the formula VIII can be prepared by coupling of the corresponding 2-mercapto-benzamides (synthesised by reduction of the corresponding 2,2'-dithiobenzamides analogous to those described in e.g. Elworthy, T. R.; Ford, A. P. D. W.; Bantle, G. W.; Morgans, D. J.; Ozer, R. S.; et al. J.MedChem. 40,1997,2674-2687) with a 5-halo- or 5-pseudohalo indole by methods analogous to those described in the literature e.g. Schopfer, U.; Schlapbach, A. Tetrahedron; 57, 2001, 3069-3073, where "halo" is either bromo or iodo or "pseudohalo" is e.g. triflate or nonaflate. When R = hydrogen in formula VIII, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a terf-butoxy-carbonyl group.
The reduction according to method 6 is performed by standard literature methods i.e. by the use of a reducing agent like borane, alane or lithium aluminium hydride. Amides of the formula IX can be prepared by coupling of the corresponding 2-mercapto-benzamides (synthesised by reduction of the corresponding 2,2'-dithiobenzamides analogous to those described in e.g. Elworthy, Todd R.; Ford, Anthony P. D. W.; Bantle, Gary W.; Morgans, David J.; Ozer, Rachel S.; et al. J.MedChem. 40,1997, 2674-2687) with a 6-halo- or 6-pseudohalo indole by methods analogous to those described in the literature e.g. Schopfer, U.; Schlapbach, A. Tetrahedron; 57, 2001, 3069-3073, where "halo" is either bromo or iodo
1 "i
or "pseudohalo" is e.g. triflate or nonaflate. When R = hydrogen in formula IX, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a terf-butoxy-carbonyl group.

The reduction according to method 7 is performed by standard literature methods i.e. by the use of a reducing agent like borane, alane or lithium aluminium hydride. Amides of the formula X can be prepared by coupling of the corresponding 2-mercapto-benzamides (synthesised by reduction of the corresponding 2,2'-dithiobenzamides analogous to those described in e.g. Elworthy, T. R.; Ford, A. P. D. W.; Bantle, G. W.; Morgans, D. J.; Ozer, R. S.;et al. J.MedChem. 40,1997, 2674-2687) with a 7-halo- or 7-pseudohalo indole by methods analogous to those described in the literature e.g. Schopfer, U.; Schlapbach, A. Tetrahedron^ 57, 2001, 3069-3073, where "halo" is either bromo or iodo or "pseudohalo" is e.g. triflate or nonaflate. When R13 = hydrogen in formula X, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a te/Y-butoxy-carbonyl group.
The reduction according to method 8 is performed by standard literature methods i.e. by the use of a reducing agent like borane, alane or lithium aluminium hydride. Amides of the formula X can be prepared by acidic rearrangement (e.g. treatment in a solution of trifluoroacetic acid) of amides of formula IV analogous to methods described in the literature (Hamel, P.; Girards M.; Tsou, N. N.; J. Heterocyclic Chem. 36,1999, 643-652; Hamel, P.; Girard, Y.; Atkinson, J. G.; J. Org. Chem. 57,1992; 2694-2699).
The deprotection according to method 9 can be performed by standard techniques, known to the persons skilled in the art and detailed in the textbook Protective Groups in Organic Synthesis Greene, T. W.; Wuts, P. G. M. Wiley Interscience, (1991) ISBN 0471623016. The protected amine can be prepared in a similar manner as described in the literature by reaction of properly substituted (2-mercapto-benzyl)-methyl-carbamic acid ester with properly substituted 4-halo indole or 4-pseudohalo indole, where "halo" is either bromo or iodo and "pseudohalo" is e.g. triflate or nonaflate, according to Schopfer, H.; Schlapbach, U.; Tetrahedron 2001, 57, 3069-3073. When R13 = hydrogen in formula XII, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a terf-butoxy-carbonyl group. The properly substituted (2-mercapto-benzyl)-methyl-carbamic acid ester can be prepared from the properly

substituted (2-hromo-benzyl)-methyl-carbamic acid ester or properly substituted (2-iodo-benzyl)-methyl-carbamic acid ester in a palladium catalysed coupling reaction with a trialkylsilane thiol with subsequent desilylation with a fluoride donor such as tetrabutylamnionium fluoride (Winn, M.; et al. J. Med. Chem. 2001, 44, 4393-4403).
The deprotection according to method 10 can be performed as described in method 9. The protected amine can be prepared from the properly substituted (2-mercapto-benzyl)-methyl-carbamic acid ester and the properly substituted 5-halo indole or 5-pseudohalo indole, where "halo" is either bromo or iodo and "pseudohalo" is e.g. triflate or nonaflate, as described in method 9. When R13 == hydrogen in formula XIII, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a ferr-butoxy-carbonyl group.
The deprotection according to method 11 can be performed as described in method 9. The protected amine can be prepared from the properly substituted (2-mercapto-benzyl)-methyl-carbamic acid ester and the properly substituted 6-halo indole or 6-pseudohalo indole, where "halo" is either bromo or iodo and "pseudohalo" is e.g. triflate or nonaflate, as described in method 9. When R13 = hydrogen in formula XIV, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a rerf-butoxy-carbonyl group.
The deprotection according to method 12 can be performed as described in method 9. The protected amine can be prepared from the properly substituted (2-mercapto-benzyl)-methyl-carbamic acid ester and the properly substituted 7-halo indole or 7-pseudohalo indole, where "halo" is either bromo or iodo and "pseudohalo" is e.g. triflate or nonaflate, as described in method 9. When R13 = hydrogen in formula XV, then this position is protected prior to the coupling reaction and deprotected after the coupling reaction according to standard literature procedures with standard protection groups, e.g. a 4-methyl-phenyl-sulfonyl group or a te/Y-butoxy-carbonyl group.
The invention disclosed herein is farther illustrated by the following non-limiting examples.

EXAMPLES General Methods
Analytical LC-MS data were obtained on a PE Sciex API 150EX instrument equipped with photoionization (APPI) ion source and Shimadzu LC-SA/SLC-10A LC system. The LC conditions (Symmetry C18 column 4.6 x 30 mm with a particle size of 3.5 |im) were linear gradient elution with eluents A (water containing 0.05% TFA) and B (acetonitrile containing 5% water and 0.035% TFA). Gradient (time[min]/%B): (0.00/10.0); (4.00/100.0); (4.10/10.0); (5.00/10.0) with 2 mL/min. Purity was determined by integration of the UV trace (254 nm) and ELS (SEDERE SEDEX 55 with Heto CBN 8-30 cooling bath). The retention times, Rt, are expressed in minutes.
Mass spectra were obtained by an alternating scan method to give molecular weight information. The molecular ion, MH>, was obtained at low orifice voltage (5V) and fragmentation at high orifice voltage (100V).
Preparative LC-MS-separation was performed on the same instrument. The LC conditions (Symmetry CI 8 column 10 x 50 mm) were linear gradient elution with eluents A (water containing 0.05% TFA) and B (acetonitrile containing 5% water and 0.035% TFA): (time[min]/%B): (0.00/20.0); (7.00/100.0); (7.10/20.0); (8.00/20.0) with 5.7 mL/min Fraction collection was performed by split-flow MS detection.
For column chromatography silica gel of formula Kieselgel 60, 230-400 mesh ASTM was used. For ion-exchange chromatography (SCX. 1 g, Varian Mega Bond Elut®, Chrompack cat. No. 220776) was used. Prior to use the SCX-columns were pre-conditioned with 10% solution of acetic acid in methanol (3 mL).
Preparation of intermediates
Example 1 2-(lH-Indol-3-ylsulfanyl)-N,N-dimethyl benzamide
^Ar,iV')A^-Tetramethyl-2J2'-dithiodibenzamide (Elworthy, Todd R.; Ford, Anthony P. D. W.; Bantle, Gary W.; Morgans, David J.; Ozer, Rachel S.; et al. J.Med. Chem. 40,1997,

2674-2687) (12.80 g, 35.5 xnmol) was dissolved in 1,2-dichloroethane (200 mL) under Ar5 and sulfurylchloride (2.9 mL, 4.84 g, 35.9 mmol) was carefully added with stirring under Ar. The reaction mixture was stirred for 15 min at room temperature and the resulting solution was added slowly (dropwise) to an icecold solution (0°C) of indole (8.4 g, 71.7 mmol) in dry DMF (180 mL) under Ar. The mixture was stirred at 0DC under Ar for 2.5 hours and then quenched by addition of water (ISO mL) and sat. aqueous NaHC03 (150 mL). To the resulting emulsion was added ethyl acetate (250 mL). The organic phases were combined and washed with brine (100 mL). The water phase was farther extracted with ethyl acetate (2x100 mL) and the combined organic phases were washed with brine and dried over MgSC>4 and evaporated in vacuo to a dark orange oil which crystallized upon standing. The product was purified and isolated by recrystallisation (acetonitrile) to give 5,53 g (26%) crystalline product (m.p. 195.6-197.6°C). From the motherliq. was further 4.45 g (21%) product isolated (m.p. 194.3-196.4°C).
The following compounds were prepared in a similar way: 2-(4-Chloro-lif-indol-3»ylsulfanyl)-Aj;A;-dimethylbenzamide 2-(4-Fluoro-liy^ndol-3-ylsulfanyl)-iV'>^-dimethylbeiiza:nide 2-(4-Fluoro-l#-indol-3-ylsulfanyl)-TV, jV-dimethyl benzamide 2-(5-Fluoro-lH-indol-3-ylsulfanyl)-A7';A^-dimethylbenzamide 2-(5-Chloro4#-indol-3-ylsulfanyl)-TV, TV-dimethyl benzamide A^7V-Dimethyl-2-(7-methyl-l^T-indol-3-ylsulfanyl)benzamide 2^5-Methoxy-liif"indol-3-ylsulfanyl)-A/,Ar-dimetl-iylbexizamide 2-(6-Fluoro-l^-indol-3-ylsulfanyl)-A^A;-dimethylbenzamide 2-(6-Chloro-li?-indol-3-ylsulfanyl)-A^,TV-dimethyl benzamide ArJAr-Dimethyl-2-(2-methyl-li?-indol-3-ylsulfanyl)benzamide 2-(6-Hydroxy-li/-indol-3-ylsulfanyl)-A^TV-dimethyl benzamide 2-(7-Methoxy- l#-indol-3-ylsulfanyl)-TV, N-dimethyl benzamide A^V-Dimethyl-2-(4-methyl-l^-indol-3-ylsulfanyl) benzamide Ar,A"-Dimethyl-2-(7-nitro-l^-indol-3-ylsulfanyl) benzamide 2-(4-Hydroxy-l#-indol-3-ylsulfanyl)-TV,TV-dimethyl benzamide 2-(4-Cyano-l^f-indol-3-ylsulfanyl)-TV,TV-dimethyl benzamide 2-(6-Cyano-lif-indol-3-ylsulfanyl)-TVTV-dimethyl benzamide

2-(7-Chloro-li^indolO-ylsulfanyl)-^A^-dimethylbenzamide 2-(6-Methoxy4i?-indol-3-ylsulfanyl)-A/;iV-dimethylbenzamide iVr,A/F-Dimethyl-2-(l -methyl- l.ff-indol-3-ylsulfanyl) benzamide 2-(4-Methoxy- lif-indol-3-ylsulfanyl)-A/; A^-dimethyl benzamide .V, #-Dimethyl-2-(6-methyl- l/Mndol-3-ylsulfanyl) benzamide
Example 2 2-(lH4ndol-3-ylsulfanyl)-7V-methyl benzamide
Carbonyldiimidazole (11 mmol) was added to a solution of 2-(l#-indol-3-ylsulfanyl) benzoic acid (Hamel, P.; Girard, M.; Tsou, N. N.; J.HeterocyclChem. 36,1999, 643 - 652) (10 mmol) in dry THF (200 mL) and refluxed for 60 minutes under argon, Methyl amine (1M in THF; 40 ml) was added slowly to the reaction mixture and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated in vacuo and the product purified by column chromatography on silica gel using ethyl acetate as an eluent.
The following compounds were prepared in a similar way: 2-(5-Fluoro-17if-indol-3-ylsulfanyl)-A?'-metliyl benzamide 2-(6-Fluoro-lif-indol-3-ylsulfanyl)-A^methyl benzamide 2-(2-Methyl-li/-indol-3-ylsulfanyl)-7^"-methyl benzamide 2-(4-Methyl-l#-indol-3-ylsulfanyl)-jV-methyl benzamide 2-(4-Chloro-l/f-indol-3-ylsulfanyl)-yV-methyl benzamide
Example 3 (2-mercapto-benzyI)-methyl-carbamic acid ferf-butyl ester
(2-Iodo-benzyl)-methyl-carbamic acid /'erf-butyl ester (5.0g, 14.4mmol) in dry toluene (30mL) was placed in two Emrys Optimizer EXP 20mL tubes. To each tube tris(dibenzylideneacetone)dipalladium (66 mg, 0.072 mmol), bis(2-diphenylphosphinophenyl)ether (78 mg, 0.14 mmol), triisopropylsilanethiol (1.44 g, 7.56 mmol) and sodium terr-butoxide (900 mg, 9.36 mmol) were added sequentially. The tubes were sealed and subjected to microwave heating at 160°C for 15 minutes. After cooling the mixture, the product was eluted through a plug of silica with ethyl acetate-heptane (1:10) to give 5.2 g (88%) of methyl«(2-triisopropylsilanylsulfanyl-benzyl)-carbamic acid te/Y-butyl ester. This product was dissolved in THF (70mL) and cooled to 0°C, Tetrabutylammonium fluoride trihydrate (4.21 g, 13.3 mmol) dissolved in THF (40 mL) was added dropwise at

0°C and the mixture was stirred at this temperature for 15 minutes. The crude mixture was poured onto a plug of silica gel and the product was eluted with ethyl acetate-heptane (1:2) to give 3.2 g (100%) of (2-mercapto-benzyl)-methyl-carbamic acid terf-butyl ester contaminated with traces of triisopropylsilane fluoride.
Example 4 Compounds of the invention of formula I
Synthesis of
L [2-(lH-Indol-3-ylsulfanyl)benzyl] dimethyl amine
2-(lH-Indol-3-ylsulfanyl)-N,N-dimethyl benzamide (1 mmol) was dissolved in dry tetrahydrofuran (30 mL). To the mixture was added 3 mL 1 M borane in tetrahydrofuran and the mixture was stirred at room temperature for 24 hours. Methanol (5 mL) was added and the mixture stirred at room temperature for 30 min and then evaporated in vacuo. The , mixture was redissolved in ethyl acetate (100 mL) and washed with saturated sodium hydrogen carbonate (20 mL), dried over anhydrous MgSC>4 and evaporated in vacuo. The product was crystallized as an oxalate salt by dissolution in acetone and addition of one equivalent of oxalic acid.
The following compounds were prepared in a similar way and analytical data are shown in table 1.:
2. [2-(5-cyano-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
3. [2-(4-Fluoro-1 #-indol-3 -ylsulfanyl)benzyl] dimethyl amine
4. [2-(4-Chloro^iWndol-3-ylsulfanyl)benzyl] dimethyl amine
5. [2-(5-Fluoro-lif-indol-3-ylsulfanyl)benzyl] dimethyl amine
6. [2-(5-Chloro-li/-indol-3"ylsulfanyl)benzyl] dimethyl amine
7. Dimethyl-[2-(7-methyl-l/f-indol»3-ylsulfanyl)benzyl] amine
8. [2-(7-Methoxy-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
9. [2-(5-Methoxy-li?-indol-3-ylsulfanyl)benzyl] dimethyl amine
10. [2-(6-Fluoro-lii/,-indol-3-ylsulfanyl)benzyl] dimethyl amine
11. [2-(6-Chloro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
12. Dimethyl-[2-(2-methyl-li?-indol-3-ylsulfanyl)benzyl] amine
13. Dimethyl-[2-(6-methyl-lif-indol-3-ylsulfanyl)benzyl] amine
14. [2-(4-cyano-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
15. Dimethyl-[2-(l»methyl-lif-indol-3-ylsulfanyl)benzyl] amine

16. Dimethyl-[2-(4-methyl-lif-indol»3-ylsulfanyl)ben2yI] amine
17. Dimethyl-[2-(4-hydroxy-lJ^-indol«3-ylsulfanyl)ben2yl] amine
18. [2-(6-cyano-li7-indol-3-ylsulfanyl)benzyl] dimethyl amine
19. [2-(7-Chloro-l#~indoI-3-ylsulfanyl)benzyl] dimethyl amine
20. [2-(6-Methoxy-lif-indol-3-ylsulfanyl)ben2yl] dimethyl amine
21. [2-(4rMethoxy-l#-indol-3-ylsulfanyl)benzyl] dimethyl amine
Example 5 Compounds of formula I Synthesis of
22. [2-(lH-Indol-3-ylsulfanyl)benzyl]methyl amine
2-Methyl-2s3-dihydro-benzoisothiazole (VI) (Hoffmann, R. W.; Goldman, S. Chem. Ber. Ill, 1978,2716-2725) (75 mg, 0.50 mmol) was dissolved in THF (1 mL) and added to indole (V) (140 mg, 0.60 mmol) under Ar. Tricloroacetic acid (90 mg, 0.55 mmol) was added and the reaction mixture was stirred at room temperature for 16 hours. 2 mL IN NaOH (aq) was added. Extraction with ethyl acetate (2x10 mL) and purification by flash chromatography on silica gel (eluent: ethyl acetate then ethyl
acetate/methanol/triethylamine) gave 88 mg [2-(lH-Indol-3-ylsulfanyl)benzyl]mcthyl amine (67% yield).
The following compounds were prepared in a similar way and analytical data are shown in Table 1:
23. [2-(6-Fluoro-lif-indol-3-ylsulfanyl)benzyl]methyl amine
24. [2-(5-Fluoro4#-indol-3-ylsulfanyl)benzyl]inethyl amine
25. Methyl-[2-(4-methyl-li?-indol-3-ylsulfanyl)benzyl] amine
26. [2-(4-Chloro-li/-indol-3-ylsulfanyl)benz}'l]methyl amine
27. Methyl-[2-(2-methyl«lH-indol-3-ylsulfanyl)benzyl] amine
28. [2-(5-Fluoro-2-methyMH-indol-3-yIsulfanyl)-benzyl]methyl amine
29. Methyl-[2-(5-methyl"lif-indol-3-ylsulfanyl)benzyl] amine
30. Methyl-[2-(7-methyl»l^-indol-3«ylsulfanyl)benzyl] amine
31. [2-(4-Fluoro-li7-indol«3-ylsulfanyl)benzyl]methyl amine
32. [2-(7-Ethyl-li?-indol-3-ylsulfanyl)benzyl]methyl amine
33. [2-(6-Methoxy-lif-indol-3-ylsulfanyl)benzyl]methyl amine
34. [2-(5-Chloro-l/7-indol-3-ylsulfanyI)benzyl]methyl amine

35. [2-(6-Chloro-liy-indol-3-ylsulfanyl)benzyl]methyl amine
36. [2-(5-Methoxy-4-methyl-lH-indol-3-ylsulfanyl)-ben2yI]methyl amine
37. [2-(5,6-Dimethoxy-lH-indol-3-ylsulfanyl)-benzyl]methy] amine
38. [2-(6-Bromo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
39. Methyl-[2-(6-methyl-lH-indol-3-ylsulfanyl)-benzyl] amine
40. [2-(4.7-Dimetlioxy-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
41. [2-(5-Methoxy-l^-indol-3-ylsulfanyl)benzyl]methyl amine
42. [2-(4-Methoxy-lif»indol"3-ylsulfanyl)benzyl]methyl amine
43. [2-(5-Bromo«lH-indol-3-ylsulfanyl)-benzyl]methyl amine
44. [2-(7-Methoxy-li/«indol-3-ylsulfanyl)ben2yl]methyl amine
45. [S-Chloro^-Ci^-indolO-ylsulfanylJ-benzylJmethyl amine
46. Methyl-[2-(6-trifluoromethyl«7i?-indol-3-ylsulfanyl)-ben2yl] amine
47. [5-Hydroxy-2-(ii^-indol-3-ylsulfanyl)-benzyl]methyl amine
48. [2»(4-Bromo-7/f-indol-3-ylsulfanyl)-benzyl]methyl amine
49. [2«(7-Chloro-/H-indol-3-ylsulfanyl)-ben2yl]methyl amine
50. [2-(5-Iodo-7/f-indol-3-ylsulfanyl)-benzyl]methyI amine
51. [2-(6-Cyano-iii/-indol-3-ylsulfanyl)-benzyl]methyl amine
52. [2-(7#-Indol-3-ylsulfanyl)-5-methyl-beri2yl]methyl amine
53. [2-(3-methyl-7i?-indol-2-ylsulfanyl)-benzyl]methyl amine
54. [2-(556-Dimethoxy-l/f-indol-3-ylsulfanyl)-5-fluoro-ben2yl]-methyl-amine
55. [5-Fluoro-2-(3-methyl-lH-indol«2-ylsulfanyl)-benzyl]"methyl-amine
56. [5-Fluoro-2-(4-fluoro-li:/-indol«3-ylsulfanyl)-benzyl]-methyl-amine
57. [2-(4-Chloro-l/f-indol-3-ylsulfanyl)-5-fluoro-ben2yl]-methyl-amine
5S. [2-(7-Chloro4iif-indol-3-ylsulfanyl)«5-fluoro-ben2yl]-methyl-amine
59. [5-Fluoro-2-(6-trifluoromethyl-li/-indol-3-ylsulfanyl)-benzyl]-methyl-amine
60. [5"Fluoro-2-(7-methoxy-lif-indol-3-ylsulfanyl)-benzyl]-methyl-amine
61. [2-(4-Bromo-li7-indol»3-ylsulfanyl)-5-fluoro-benzyl]-methyl«amine
62. 3-(4»Fluoro-2-methylaminomethyl-phenylsulfanyl)-2-methyl-liif-indol-4-ol
63. 3-(4-Fluoro-2-methylaminomethyl-phenylsulfanyl)- l#-indol-6-ol
64. [5-Fluoro-2-(5-fluoro4iif-indol-3-ylsulfanyI)-benzyl]-methyl-amine
65. [5»FluorO"2-(4-methoxy-l/f-indol-3-ylsulfanyl)-benzyl]-methyl-amine
66. [2-(6-Chloro-l//"-indol-3-ylsulfanyl)-5"fluoro-ben2yl]-methyl»aniine
67. [2-(5-Chloro-liy-indol-3-ylsulfanyl)-5»fluoro-benzyl]-methyl-amine

68. [5-Fluoro-2-(6-methyM#-m^^
69. [5-Fluoro-2-(5-methoxy-4-methyl-l/^indol-3-ylsulfanyl)-benzyl]-m
70. [2-(5-Bromo-lif-indol-3-ylsulfanyl)-5-fluoro-ben2yl]-methyl-amine
71. [5-Fluoro-2-(5-methoxy-lif-indoI-3-ylsulfanyl)-benzyl]-methyl-amine
72. [2-(6-Bromo-lif-indol-3-ylsidfanyl)-5-fluoro-ben2yl]-methyl-amiiie
73. [5-Fluoro-2-(6-fluoro-l^ndolO-ylsulfanyl)-benzyl]-methyl-amine
74. [5-Fluoro-2«(6-methoxy«li/-indol-3-ylsulfanyl)-ben2yl]-methyl--amitie
75. [5-Fluoro-2-(2-methyl-ljy-indol-3-ylsulfanyl)-bBiizyl]-methyl-amine
76. [5-Fluoro-2-(5-methyl4i7-indol-3-ylsulfanyl)-benzyl]-methyl-amine
77. [5-Fluoro-2-(4-methyl-l/y-indol-3-ylsulfanyl)-benzyI]-inethyl-amine
78. [5-FIuoro-2-(7-methyl-liif-indol-3-ylsulfanyl)-beii2yl]-methyl-amine
79. [5-Fluoro-2-(l-methyl-lif"indol-3-ylsulfanyl)«benzyl]--methyl-arnine
80. [5-Fluoro-2~(5-fluoro-2-methyM
81. [5-Chloro-2-(5-fluoro-li/-indol-3-ylsulfanyl)-benzyl]-methyl-amine
82. [5-Chloro-2-(5-methoxy-li/-indol-3-ylsulfanyl)-ben2yl]-methyl-amine
83. [5-Chloro-2«(7«methyl4^-indol-3-ylsulfanyl)-ben2yl]«methyl"amine
84. [5-Chloro-2-(l-methyl4i/-indol-3-ylsulfanyl)-benzyl]«methyl-amine
85. [5-Chloro-2-(4-methoxy4^4ndol-3-ylsulfanyl)-beri2yl]-methyl-aniine
86. [5-Chloro-2-(7-methoxy-l/f4ndol-3-ylsulfanyl)-benzyl]-methyl-amine
87. [5-Chloro-2-(6-fluoro-lif-indol-3-ylsulfanyl)-benzyl]-inethyl-amine
88. [5-Chloro-2-(5-fluoro-2-methyM
89. [2-(5-Fluoro-2-methyl-l//-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-am
90. Methyl-[5-methyl-2-(4"methyl4^-indol-3-ylsulfanyl)-benzyl]-amine
91. [2 92. [2-(6-Methoxy-l#4ndol-3-ylsulfanyl)-^^
93. Methyl-[5-methyl-2-(2-methyl-l#-indol-3-ylsulfanyl)-benzyl]-amine
94. [2-(4-Methoxy-l#-indol*3-ylsulfanyl)^
95. [2-(6-Bromo-lif-indolO-ylsulfanyl)-5«methyl-benzyl]-meth}rl-amine
96. [2»(6«Fluoro4iy4ndol-3«ylsulfanyl)-5-methyl-benzyl]-methyl-amine
97. [2-(4-Fluoro4iif-indol-3-ylsulfanyl)»5-methyl-benzyl]-niethyl-amine
98. 3-(4-Methyl-2-methylaminomethyl-phenylsulfanyl)-lif-indol-6-ol
99. [5-Chloro-2
101.[2-(5-Chloro-l#-indol-3-ylsu^
105. [4-Chloro-2-(6-methyl-l#-indolO^^
106. [4-Chloro«2-(2-methyl-l//4ndol-3-ylsulfanyl)-benzyl]-methyl-amine
107. [4-Chloro-2-(5-methyl-lH4ndol-3-ylsulfanyl)-ben2yl]-methyl-amine
108. [4-Chloro-2-(7-methyl-l^-indol-3-ylsulfanyl)-benzyl]-methyl-amine
109. [4-Chloro-2-(4-methyl-l/f-indol-3-ylsulfanyl)-benzyl]-methyl-amine
110. [4-Chloro*2-(5-fluoro4i/4ndol-3-ylsulfanyl)-benzyl]-methyl-arnine
111. [4-Chloro-2-(6-fluoro-liir-indol-3-ylsulfanyl)-beii2yl]-methyl-amine 112.[4-Chloro-2"(4«fluoro-l/^-indol-3-ylsulfanyl)-benzyl]-methyl-aniine 113.[4-Chloro-2-(7-fluoro4ii/-indolO-ylsulfanyl)-benzyl]-methyl-amme 114.[4-Chloro-2-(7-ethyl4H4ndolO-ylsulfanyl)-ben2yl]-methyl-amine

115. [4-Chloro-2-(5-methoxy-4-methyM#-m^
116. [4-Chloro-2-(5-methoxy- l/f-indol-3-ylsulfanyl)-ben2yl]-methyl-amine 117.[4-Chloro-2-(6-methoxy-liWn^^

118, [4-ChlorO'2-(7-methoxy-lH-indolO-ylsulfanyl)-ben2yl]»methyl-amine
119, [4-Chloro«2-(4-methoxy4iy 125. [4-Chloro-2-(l -methyl- l^-indol-3-ylsulfanyl)-benzyl]-methyl-amine
126,[4-Chloro-2-(3~methyl-l#-indol-2^
127.[4-Chloro-2-(5-fluoro-2-methyl-lfW^
129.[2-(5-Fluoro-4-methoxy-liy-indol-3-ylsulfanyl)-ben2yl]-methyl-ainine
130.[2-(4,5-Difluoro«li7-indol-3-yIsulfanyl)-benzyl]-methyl-amine
131i[2-(4,6-Difluoro-lJ^-indol-3-ylsulfanyl)-benzyl]-methyl-amine
132.3-(2-Methylaminomethyl-phenylsulfanyl)-li^-indol-4-ol
134.[2-(5,6-Difluoro-li/-indol-3-ylsulfanyl)-benzyl]-methyl-amine
135.6-Fluoro-3-(2-methylaminomethyl-phenylsulfanyl)-li?-indol-5"Ol
136.[2-(4-Chloro-l^-indolO-ylsulfanyl)-5-methyl-benzyl]-methyl-ainine
Example 6 Compounds of formula I

Synthesis of
102. 5-FUwro-3-(2-piperidin-l-ylmethyl-phenylsu^
6 mL cone. H2S04 was added to 2,2'-dithiodibenzoic acid (20 g, 65.3 mmol) in 150 mL methanol. The reaction mixture was refluxed for three days, cooled to room temperature and neutralized with sat. aqueous NaHCC>3. Methanol was removed in vacuo. The residue was extracted with ethyl acetate. The organic phase was washed with brine, dried with MgSCU and concentrated in vacuo to give 17.8 g dimethyl 2,2l-dithiodibenzoic acid ester (53.2 mmol, 82%). 1.20 mL Sulfurylchloride (15 mmol) was added to 5.00 g dimethyl 2,2'-dithiodibenzoic acid ester (15 mmol) in 40 mL dry 1,2-dichloroethane under Ar at 0°C. The reaction mixture was stirred 15 min at room temperature and added to 4.10 g fluoro-lif-indole (30.3 mmol) in 50 mL dry THF under Ar. The reaction mixture was stirred for 2 hours at room temperature and then quenched by addition of sat. aqueous NaHC03. Ethyl acetate was added, the two phases were separated and the organic phase was washed with brine, dried with MgS04 and concentrated in vacuo. 8.30 g 2-(5-Fluoro-l#-indol-3-ylsulfanyl)-benzoic acid methyl ester (27.5 mmol, 92%) was isolated after flash chromatography on silica gel, 4.15 g 2-(5-Fluoro-l#-indol-3-ylsulfanyl)-benzoic acid methyl ester (13.8 mmol) in 50 mL dry THF was added drop wise to 0.5 8g LiAIKU (15.4 mmol) in 20 mL dry diethyl ether at 0°C. 150 mL dry THF was added and the reaction mixture was stirred 16 hours at room temperature. The raction was quenched with 1 mL water and 1 mL 2N NaOH. The reaction mixture was stirred for 1 hour, then 2.5 mL water was added and stirring was continued for another hour. The mixture was filtered, dried with MgSOa and concentrated in vacuo to give 3.00 g 2-(5-fluoro-lif-indol-3-ylsulfanyl)-phenyl]-methanol (11.0 mmol, 80%). 0.275g/?-Toluenesulfonylchloride (1.44 mmol) was added to 0.375g 2-(5-fluoro-l/Wndol-3-ylsulfanyl)-phenyl]-methanol (1.37 mmol) in 5 mL dry THF at 0°C. The reaction mixture was stirred 2 hours at 0°C and then added to 2.75 mmol piperidine in 10 mL dry THF and stirred 16 hours at room temperature. Water and ethyl acetate were added to the reaction mixture. The two phases were separated and the organic phase was washed with brine, dried with MgS04 and concentrated in vacuo. 5-Fluoro-3-(2-piperidin-l-ylmethyl-phenylsulfanyl)-liV«indole was isolated after flash chromatography.

The following compounds were prepared in a similar way and analytical data are shown in Table 1:
103.5-Fluoro-3-(2-morpholin-4-ylmethyl-phenylsulfanyl)-liif-indole
104.5-Fluoro-3-(2-pyrrolidin-l-ylmethyl-phenylsulfanyI)-li?-indole
Example 7 Compounds of formula I
Synthesis of
128. 2-(5-Fluoro-lH-indol-3-yIsulfanyl)-benz)Jlamine
4,50 g NaBH* (119 mmol) was added in portions to 7.50 g aliyl bromide (62.0 mmol) and 8.35 g 2,2'~dithiodibenzamide (27.4 mmols prepared from 2,2,-dithiodibenzoic acid via 2,2'-dithiodibenzoic acid chloride) in 80 mL methanol at 0°C. The reaction mixture was stirred 1 hour at room temperature. 50 mL IN HC1 was added and stirring was continued 1 hour. Methanol was removed in vacuo. Jhe residue was extracted with ethyl acetate. The organic phase was washed with brine, dried with MgS04 and concentrated in vacuo to give 10,0 g 2-allylsulfanyl-benzamide (51.7 mmol, 94%). 2.1 g LiAlH4 (55 mmol) was added to 6.0 g 2-allylsulfanyl-benzamide (31 mmol) in 50 mL dry THF at 0DC. The reaction mixture was stirred for 16 hours at room temperature. The reaction was quenched with 4 mL water and 3 mL 2N NaOH. The reaction mixture was stirred for 1 hour, then 9 mL water was added and stirring was continued for another hour. The mixture was filtered, dried with MgS04 and concentrated in vacuo to give 5.05 g 2-allylsulfanyl-benzylamine (28.2 mmol, 91%). 2.05 g Di-terf-butyl dicarbonate (9.37 mmol) was added to 1.40 g 2-allylsulfanyl-benzylamine (7.SI mmol) and a catalytic amount of JV^V-dimethyl-4-amino pyridine in 20 mL THF. The reaction mixture was stirred for 15 minutes at room temperature. 10 mL 20% citric acid was added and the reaction mixture was stirred for 30 minutes. The reaction mixture was extracted with ethyl acetate, the two phases were separated and the organic phase was washed with brine, dried with MgS04 and concentrated in vacuo to give (2-allylsulfanyl-benzyl)-caxbamic acid te/7-butyl ester in quantitative yield. 0.70g NaI04 (3.3 mmol) in 20 mL water was added to 0.75 g (2-allylsulfanyl-benzyl)-carbamic acid terf-butyl ester (2.7 mmol) in 20 mL methanol and stirred for 2 hours at room temperature. The reaction mixture was filtered and methanol was removed in vacuo. The residue was extracted with ethyl acetate. The organic phase was washed with brine, dried with MgS04 and concentrated in vacuo. The residue was redissolved in 5 mL THF and added to 0.50 g fluoro-l#-indole (3.7 mmol) and 0.65 g trichloro acetic acid (4.0 mmol) in 5 mL THF and stirred for 16 hours at

50°C. Sat. aqueous NaHCC>3 and ethyl acetate was added, the two phases were separated and the organic phase was washed with brine, dried with MgSCU and concentrated in vacuo. The residue was purified by flash chromatography and 0.157g [2-(5-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-carbamic acid terf-butyl ester (0.42 mmol, 16%) was isolated after recrystallization from ethyl acetate/heptane. 8 mL diethyl ether saturated with HC1 was added to 0.157g [2-(5-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-carbainic acid terf-butyl ester (0.42 mmol) in 8 mL methanol and stirred 16 hours. The reaction was neutralized with 2N NaOH and extracted with ethyl acetate. The organic phase was washed with brine, dried with MgS04 and concentrated in vacuo to give 0.112 g 2-(5-fluoro-l#-indol-3-ylsulfanyl)-benzylamine (98%).
The following compound was prepared in a similar way and analytical data are shown in Table 1:
133. 2-(6-Fluoro-lif-indol-3-ylsulfanyl)-benzylamine
Example 8 Compounds of formula I Synthesis of [2-(lH-Indol-5-ylsulfanyl)-benzylJ-methyl-amine
(2-Mercapto-benzyl)-methyl-carbamic acid ferf-butyl ester (1.85g, 7.30mmol) in dry toluene (15mL) is placed in an Emrys Optimizer EXP 20mL tube. Tris(dibenzylideneacetone) dipalladium (334 mg, 0.37 mmol), bis(2-diphenylphosphinophenyl)ether (197 mg, 0.37 mmol), terf-butyl-5-bromoindole-l-carboxylate (2.38 g, 8.03 mmol) and potassium terf-butoxide (860 mg, 7.67 mmol) are added. The reaction vessel is sealed and subjected to microwave heating at 160°C for 15 minutes. Upon cooling the mixture is poured onto a plug of silica and the product is eluted with ethyl acetate-heptane (1:4). 0.67 g (20%) of 5-{2-[(ferf-butoxycarbonyl-methyl-amino)-methyl]-phenylsulfanyl}-indole-1-carboxylic acid f erf-butyl ester is isolated and used in the next step whithout further purification. 5-{2-[(te/t-butoxycarbonyl-methyl-amino)-methyl]-phenylsulfanyl}-indole- 1-carboxylic acid terf-butyl ester (0.67g, 1.43mmol) in methanol (15mL) and diethyl ether saturated with hydrochloric acid (15mL) is stirred at room temperature for 1 hour and concentrated in vacuo. Ice/water is added to the remanence and 28% aqueous NaOH is added until pH 9. The aqueous fraction is extracted with ethyl acetate (3 x 15mL). Combined organic fractions are dried with MgS04

and concentrated in vacuo. The product is purified by silica gel chromatography eluting with ethyl acetate-triethyl amine (100:4) followed by ethyl acetate-ethanol-triethyl amine (100:5:5). Upon evaporation of the volatiles, 40 mg (10%) of [2-(ltf-indol-5-ylsulfanyl)-benzyl]-methyl-amine is isolated.
The following compounds are prepared in a similar way:
[2-(li7-Indol-4-ylsulfanyl)-benzyl]-methyl-amine [2-(l/7-Indol-6-ylsulfanyl)-benzyl]-methyl-amine [2-(liy-Indol-7-ylsulfanyl)-benzyl]-methyl-amine
rid







Example 9 Transporter binding assay
Measurements of [3H]-5-HT uptake into rat cortical synaptosomes
Whole brains from male Wistar rats (125-225 g), excluding cerebellum, are homogenized in 0.32 M sucrose supplemented with ImM nialamid with a glass/teflon homogenizer. The homogenate is centrifuged at 600 x g for 10 min at 4 °C. The pellet is discarded and the supernatant is centrifuged at 20.000 x g for 55 min. The final pellet is homogenized (20 sec) in this assay buffer (0.5 mg original tissue/well). Test compounds (or buffer) and 10 nM [3H]-5-HT are added to 96 well plates and shaken briefly. Composition of assay buffer: 123 mM NaCl, 4.82 mM KC1, 0.973 mM CaCi2; 1.12 mM MgS04, 12.66 mM Na2HP04? 2.97 mM NaH2P04, 0.162 mM EDTAS 10 mM glucose and 1 mM ascorbic acid. Buffer is oxygenated with 95% 02/5% C02 for 10 min at 37 °C and pH is adjusted 7.4. The incubation is started by adding tissue to a final assay volume of 0.2 mL. After 15 min incubation with radioligand at 37 °C, samples are filtered directly on Unifilter GF/C glass fiber filters (soaked for 1 hour in 0.1% polyethylenimine) under vacuum and immediately washed with 3 x 0.2 ml assay buffer. Non-specific uptake is determined using citalopram (10 \xM final concentration). Citalopram is included as reference in all experiments as dose-response curve.
Measurements of [3H]noradrenaline uptake into rat cortical synaptosomes
Fresh cortex from male Wistar rats (125-225 g) are homogenized in 0.4M sucrose with a glass/teflon homogenizer. The homogenate is centrifuged at 600 x g for 10 min at 4 °C. The pellet is discarded and the supernatant is centrifuged at 20.000 x g for 55 min. The final pellet is homogenized (20 sec) in this assay buffer (6 mg original tissue/mL = 4 mg/well). Test compounds (or buffer) and 10 nM [3H]-noradrenaline are added to deep 96 well plates and shaken briefly. Composition of assay buffer: 123 mM NaCl, 4.82 mM KC1, 0.973 mM CaCl2, 1.12mMMgS04, 12.66 mMNa2HP04s 2.97 mMNaH2P04, 0.162 mMEDTA, 10 mM glucose and 1 mM ascorbic acid. Buffer is oxygenated with 95% 02/5% C02 for 10 min at 37 °C and pH is adjusted 7.4. The incubation is started by adding tissue to a final assay volume of 1 ml. After 15 min incubation with radioligand at 37 °C, samples are filtered directly on Unifilter GF/C glass fiber filters (soaked for 1 hour in 0.1% polyethylenimine) under vacuum and immediately washed with 3 x 1 mL assay buffer. Non-specific uptake is determined using talsupram (10 \xM final concentration). Duloxetine is included as reference in all experiments as dose-response curve.

Results of the experiments showed that the tested compounds of the invention inhibit the serotonin and norepinephrine reuptake with IC50 below 200 nM.
Measurements of [3H]dopamine uptake into rat synaptosomes
Tissue preparation: male wistar rats (125-250 g) are sacrificed by decapitated and striatum
quickly dissected out and placed in 40 vol (w/v) ice cold 0,40 M sucrose. The tissue is
gently homogenised (glass teflon homogeniser) and the P2 fraction is obtained by
centrifugation (1000 g, 10 minutes and 40000 g, 20 minutes, 4°C) and suspended in 560
volumes of a modified Krebs-Ringer-phosphate buffer, pH 7,4.
Tissue 0,25 mg/well(140|il) (original tissue) is mixed with test suspension. After 5 minutes
pre-incubation 12.5 nM 3H-dopamine is added and the mixture is incubated for 5 minutes at
RT.
The incubation is terminated by filtering the samples under vacuum through Whatman GF/C
filters with a wash of 1 ml buffer. The filters are dried and appropriate scintillation fluid
(Optiphase Supermix) is added. After storage for 2 hours in the dark the content of
radioactivity is determined by liquid scintillation counting. Uptake is obtained by
subtracting the non-specific binding and passive transport measured in the presence of 100
[xM of benztropin. For determination of the inhibition of uptake ten concentrations of drugs
covering 6 decades are used.
3H-DA = 3.4-(ring-2,5,6-3H)dopamine hydrochloride from New England Nuclear, specific
activity 30-50 Ci/mmol.
Hyttel, Biochem. Pharmacol. 1978, 27,1063-1068;
Hyttel, Prog. Neuro-Psychopharmacol. & bil. Psychiat. 1982, 6, 277-295;
Hyttel & Larsen, Acta Pharmacol. Tox. 1985, 56, suppl. 1, 146-153.







CLAIMS
1. A compound of the general formula I:

wherein the sulphur atom is attached to the indole via any ring carbon of the indole-and wherein
- R*-R2 are independently selected from hydrogen, Ci_6-alk(en/yn)yl, C3.S-cycloalk(en)yl, and C3-g-cycloalk(en)yl-Ci-6-alk(en/yn)yl or R1 and R2 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur;
- R3-R12 are independently selected from hydrogen, halogen, cyano, nitro, Ci-6-alk(en/yn)yl, C3.8-cycloalk(en)yl, C3-8-cycloaIk(en)yl-C1-6-alk(en/yn)yls amino, Ci-6-alk(en/yn)ylamino, di-(Ci.6-alk(en/yn)yl)amino, C1.6-alk(en/yn)ylcarbonyl, aminocarbonyl. Ci.6-alk(en/yn)ylaminocarbonyl, di-(Ci-6-alk(en/yn)yl)aminocarbonyl, hydroxy, Ci^-alk(en/yn)yloxy, Ci-6-alk(en/yn)ylthio, halo-Ci.6-alk(en/yn)yl,halo-Ci.6-alk(en/yn)ylsulfonyl, halo-Ci.e-alk(en/yn)ylsulfanyl and C1-6-alk(en/yn)ylsulfonyl; and
- R13 is selected from hydrogen, Ci.6-alk(en/yn)yl, C3-8-cycloalk(en)yl and C3-8-cycloalk(en)yl-C1.6-alk(en/yn)yl;
as the free base or a salt thereof; with the provisos that:
- when the sulphur atom is attached via atom nr. 2 of the indole then R7 does not exist;
- when the sulphur atom is attached via atom nr. 3 of the indole then R12 does not exist;
- when the sulphur atom is attached via atom nr. 4 of the indole then Rs does not exist;

- when the sulphur atom is attached via atom nr. 5 of the indole then R9 does not exist;
- when the sulphur atom is attached via atom nr. 6 of the indole then R10 does not exist; and
- when the sulphur atom is attached via atom nr. 7 of the indole then R1: does not exist.

2. A compound according to claim 1 wherein R1 and R2 are independently selected from hydrogen and Ci.6-alk(en/yn)yl; or R1 and R2 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally the ring in addition to the nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur.
3. A compound according to any one of claims land 2 wherein R3-R12 are independently selected from hydrogen, halogen, cyano, Ci^-alk(en/yn)yl, hydroxy, Ci-6-alk(en/yn)yloxy and halo-Ci-6-alk(en/yn)yl.
4. A compound according to any one of claims 1-3 wherein R3-R6 are independently selected from hydrogen, halogen and C1-6-alk(en/yn)yl.
5. A compound according to any one of claims 1-4 wherein R -R are independently selected from hydrogen, halogen, cyano, C1-6-alk(en/yn)yl, hydroxy, C1.6-alk(en/yn)yloxy and halo-C1-6-alk(en/yn)yl.
6. A compound according to any one of claims 1-5 wherein R13 is selected from hydrogen and C1-6-alk(en/yn)yl.
7. A compound according to any one of claims 1-6, said compound being selected from the following list of compounds:
Compound Compound name
no.
1 [2-(lH-Indol-3-ylsulfanyl)benzyl] dimethyl amine

2 [2-(5-cyano-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
3 [2-(4-Fluoro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
4 [2-(4-Chloro-lH-indol-3-ylsulfanyI)benzyl] dimethyl amine

5 [2-(5-Fluoro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
6 [2-(5-Chloro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
7 Dimethyl-[2"(7-methyl-lH-indol-3-ylsulfanyl)benzyI]-amine
8 [2-(7-Methoxy-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
9 [2-(5-Methoxy-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
10 [2-(6-Fluoro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
11 [2-(6-Chloro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
12 Dimethyl-[2-(2-methyl-lH-indol-3-ylsulfanyl)benzyl]-amine
13 Dimethyl-[2-(6-methyl"lH-indol-3-ylsulfanyl)benzyl]-amine
14 [2-(4-cyano-lH-indol-3-ylsulfanyl)ben2yI] dimethyl amine
15 Dimethyl- [2-( 1 -methyl-1H- indol-3 -ylsulfanyl)benzy 1] amine
16 Dimethyl-[2-(4-methyl*lH-indol-3-ylsulfanyl)benzyl] amine
17 [2-(4-Hydroxy-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
18 [2-(6-cyano-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
19 [2-(7-Chloro-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
20 [2-(6-Methoxy-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
21 [2-(4-Methoxy-lH-indol-3-ylsulfanyl)benzyl] dimethyl amine
22 [2-(lH-Indol-3-ylsulfanyl)benzj'l]methyl amine
23 [2-(6-Fluoro-lH-indol-3-ylsulfanyI)benzyl]methyl amine
24 [2-(5-Fluoro-lH-indol-3-ylsuIfanyl)benzyl]methyl amine
25 Methyl-[2-(4-methyl-lH-indol-3-ylsulfanyl)benzyI] amine
26 [2-(4-Chloro-lH-indol-3-ylsulfanyl)benzyl]methyl amine
27 Methyl-[2-(2-methyl-lH-indol-3-ylsulfanyl)benzyl] amine
28 [2-(5-Fluoro-2-methyl-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
29 Methyl-[2-(5-methyl-lH-indol-3-ylsulfanyl)benzyl] amine
30 Methyl-[2-(7-methyl-lH-indol-3-ylsulfanyl)benzyl] amine
31 [2-(4-Fluoro-lH-indol-3-ylsulfanyl)benz>'l]methyl amine
32 [2-(7-Ethyl-lH-indol-3-ylsulfanyl)benzyl]methyl amine
33 [2-(6-Methoxy-lH-indoI-3-ylsulfanyl)benzyl]methyl amine
34 [2-(5-Chloro-lH-indol-3-ylsulfanyl)benz>'l]methyl amine
35 [2-(6-Chloro-lH-indol-3-ylsulfanyl)benz}'l]methyl amine
36 [2-(5-Methoxy-4-methyl-lH-indol-3-ylsulfanyl)-benzyl]methyl amine

37 [2-(5,6-Dimethoxy-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
38 [2-(6-Bromo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
39 Methyl-[2-(6-methyl-lH-indol-3-yIsulfanyl)-benzyl] amine
40 [2-(4s7-Dimethoxy-lH-indol-3-ylsulfanyI)-benzyl]methyl amine
41 [2-(5-Methoxy-lH-indol-3-ylsulfanyl)benzyl]methyl amine
42 [2-(4-Methoxy-lH-indol-3-ylsulfanyl)benzyI]methyI amine
43 [2-(5-Bromo-lH-indol-3-ylsulfanyI)-benzyl]methyI amine
44 [2-(7-Methoxy-lH-indol-3-ylsuIfanyl)benzyl]methyl amine
45 [5-Chloro-2-(lH-indol-3-ylsulfanyI)-benzyI]methyl amine
46 Methyl-[2-(6-trifluoromethyl-lH-indol-3-ylsulfanyl)-benzyl] amine
47 [2-(5-Hydroxy-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
48 [2-(4-Bromo-lH-indol-3-ylsulfany])-benzyl]methyl amine
49 [2-(7-Chloro-lH-indoI-3-ylsulfanyl)-benzyl]methyl amine
50 [2-(5-Iodo-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
51 [2-(6-Cyano-lH-indol-3-ylsulfanyl)-benzyl]methyl amine
52 [2-(lH-Indol-3-ylsuIfanyl)-5-methyl-benzyl]methyl amine
53 Methyl-[2-(3-methyl-lH-indol-2-y!sulfanyl)-benzyl] amine
54 [2-(5,6-Dimethoxy-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
55 [5-Fluoro-2-(3-methyl-lH-indol-2-ylsulfanyl)-ben2yl]-methyl-amine
56 [5-Fluoro-2-(4-fluoro-lH-indol-3-ylsulfanyI)-benzyI]-methyl-amine
57 [2-(4-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
58 [2-(7-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
59 [5-Fluoro-2-(6-trifluoromethyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
60 [5-Fluoro-2-(7-methoxy-lH-indoI-3-ylsulfanyI)-benzyl]-methyl-amine
61 [2-(4-Bromo-lH-indol-3-ylsulfanyI)-5-fluoro-benzyl]-methyl-amine
62 3-(4-Fluoro-2-methylaminomethyl-phenylsulfanyl)-2-methyl-lH-indol-4-ol
63 3-(4-Fluoro-2-methylaminomethyl-phenylsulfanyl)-lH-indol-6-ol
64 [5-Fluoro-2-(5-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
65 [5-Fluoro-2-(4-methoxy-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
66 [2-(6-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
67 [2-(5-Chloro-lH-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
68 [5-Fluoro-2-(6-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methy]-amine
69 [5-Fluoro-2-(5-methoxy-4-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyI-amine
70 [2-(5-Bromo-lH-indol-3-ylsulfanyI)-5-fluoro-ben2yl]-methy]-amine

71 [5-Fluoro-2-(5-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
72 [2-(6-Bromo-lH-indoI-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine
73 [5-FIuoro-2-(6-fluoro-lH-indoI-3-ylsulfanyl)-benzyl]»methyl-amine
74 [5-Fluoro-2-(6»methoxy-lH-indol-3-ylsulfanyl)-benzyI]-methyl-amine
75 [5-Fluoro-2-(2-methyI-lH-indoI-3-ylsulfanyl)-benzyl]-methyl-amine
76 [5-Fluoro-2-(5-methyI-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
77 [5-Fluoro-2-(4-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyI-amine
7S [5-Fluoro-2-(7-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
79 [5-Fluoro-2-(l-methyl-lH-indol-3-ylsulfanyl)-benzyI]-methyl-amine
80 [5-Fluoro-2-(5-fluoro-2-methyI-lH-indol-3-ylsulfanyl)-benzyI]-methyl-amine
81 [5-Chloro-2-(5-fluoro-lH-indol-3-ylsulfanyl)-ben2yl]-methyl-amine
82 [5-Chloro-2-(5-methoxy-lH-indol-3-ylsulfanyI)-benzyl]-methyI-amine
83 [5-Chloro-2-(7-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
84 [5-Chloro-2-(l-methyl-lH-indol-3-ylsulfanyl)-benzyI]-methyl-amine
85 [5-Chloro-2-(4-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyI-amine
86 [5-Chloro-2-(7-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyI-amine
87 [5-Chloro-2»(6-fluoro-lH-indol-3-ylsulfanyl)-benz>'l]-methyl-amine
88 [5-Chloro-2-(5-fluoro-2-methyl-lH-indol-3-ylsuIfanyl)-benzyI]-methyl-amine
89 [2-(5-Fluoro-2-methyl-lH-indol-3-yIsulfanyI)-5-methyl-benzyI]-methyl-amine
90 Methyl-[5-methyl-2-(4-methyl-lH-indol-3-ylsulfanyl)-benzyI]-amine
91 [2-(7-Ethyl-lH-indol-3-ylsuIfanyl)-5-methyl-benzyl]-methyl-amine
92 [2-(6-Methoxy-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyI-amine
93 Methyl-[5-methyl-2-(2-methyI-lH-indol-3-ylsulfanyl)-benzyl]-amine
94 [2-(4-Methoxy-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyI-amine
95 [2-(6-Bromo-lH-indol-3-ylsulfanyl)-5-methyI-benzyl]-methyl-amine
96 [2-(6-Fluoro-lH-indol-3-ylsulfany])-5-methyl-benzyI]-methyl-amine
97 [2-(4-Fluoro-lH-indol-3-ylsuIfanyl)-5-methyl-benzyl]-methyl-amine
98 3-(4-Methyl-2-methylaminomethyl-phenyIsulfanyl)-lH-indol-6-ol
99 [5-Chloro-2-(5-methyl-lH-indol-3-ylsulfanyl)-benzyI]-methyl-amine
100 [2-(6-Chloro-lH-indol-3-ylsuIfanyI)-5-methyl-benzyI]-methyl-amine
101 [2-(5-ChIoro-lH-indol-3-ylsulfanyl)-5-methyl-benzyI]-methyl-arnine
102 5-Fluoro-3-(2-piperidin-l-ylmethyl-phenylsulfanyI)-lH-indole
103 5-Fluoro-3-(2-morphoIin-4-yImethyI-phenylsulfanyl)-lH-indoIe
104 5-Fluoro-3-(2-pyrrolidin-l-ylmethyl-phenylsulfanyl)-lH-indole
105 [4-ChIoro-2-(6-methyl-lH-indol-3-ylsulfanyl)-benzj'I]-methyl-amine

106 [4-Chloro-2-(2-methyI-lH-indol-3-ylsulfanyl)-benzyl]-methyI-amine
107 [4-Chloro-2-(5-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
108 [4-Chloro-2-(7-methyl-lH-indoU3-ylsulfanyI)-ben2yl]-methyl-amine
109 [4-Chloro-2-(4-methyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
110 [4-Chloro-2-(5-fluoro-lH-indol-3-ylsulfanyl)-benzyI]-methyi-amine
111 [4-Chloro-2-(6-fluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
112 t4-Chloro-2-(4-fluoro-lH-indoI-3-ylsulfanyl)-bBnzyl]-methy]-amine
113 [4-Chloro-2-(7-fluoro-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
114 [4-Chloro-2-(7-ethyl-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
115 [4-Chloro-2-(5-methoxy-4-methyl-lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
116 [4-Chloro-2-(5-methoxy-lH-indol-3-yIsulfanyl)-benzyl]-methyI-amine
117 [4-Chloro-2-(6-methoxy-lH-indol-3-ylsulfanyl)-benzyI]-methyI-amine
118 [4-Chloro-2-(7-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyI-amine
119 [4-Chloro-2-(4-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
120 [4-Chloro-2-(5-chloro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
121 [4-Chloro-2-(6-chloro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
122 [4-Chloro-2-(4-chloro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-ambe
123 [4-Chloro-2-(7-chloro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
124 [4-Chloro-2«(lH-indol-3-ylsulfanyI)-benzyl]-methyl-amine
125 [4-Chloro-2-(l-methyl-lH-indoM-ylsulfanyl)-benzyl]-methyl-amine
126 [4-Chloro-2-(3-methyl-lH-indol-2-ylsulfanyl)-benzyl]-methyl-amine
127 [4-Chloro-2-(5-fluoro-2-methyl-lH-indol-3-ylsulfanyl)-benzyI]-methyl-amine
128 2-(5-Fluoro-lH-indol-3-ylsulfanyl)-benzylamine
129 [2-(5-Fluoro-4-methoxy-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
130 [2-(4,5-Difluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
131 [2-(4,6-Difluoro-lH-indol-3-y]sulfanyl)-benzyl]-methyl-amine
132 3-(2-Methylaminomethyl-phenylsulfanyl)-lH-indol-4-ol
133 2-(6-Fluoro-lH-indol-3-ylsulfanyl)-benzylamine
134 [2-(5,6-Difluoro-lH-indol-3-ylsulfanyl)-benzyl]-methyl-amine
135 6-Fluoro-3-(2-methylaminomethyl-phenylsulfanyl)-lH-indol-5-ol
136 [2-(4-Chloro-lH-indol-3-ylsulfanyl)-5-methyl-benzyl]-metliyl-amine
13 7 [2-( 1 H-Indol-5 -y lsulfanyl)-benzyl]-methyl-amine
13 8 [2-( 1 H-IndoI-4-ylsulfanyl)-benzyl]-methyl-amine
139 [2-(lH-Indol-6-ylsulfanyl)-benzyl]-methyl-amine

140 [2-(lH-Indol-7-ylsulfanyI)-benzj'I]-methyI-amine
as the free base or a salt thereof
8. A pharmaceutical composition comprising a compound according to any one of claims
1-7 and at least one pharmaceutical^ acceptable carrier or diluent.
9. Use of a pharmaceutical composition according to claim 8 for the inhibition of the
serotonin transporter.
10. Use according to claim 9 for the treatment of a disease or disorder wherein a serotonin
reuptake inhibitor is beneficial.
11. Use of a pharmaceutical composition according to claim 8 for the inhibition of the
serotonin and noradrenaline transporters.
12. Use according to claim 11 for the treatment of a disease or disorder, wherein a
combined serotonin and norepinephrine reuptake inhibitor is beneficial.
13. Use of a pharmaceutical composition according to claim 8 for the inhibition of the
serotonin, noradrenaline and dopamine transporters.
14. Use according to claim 13 for the treatment of a disease or disorder, wherein a
combined serotonin, norepinephrine and dopamine reuptake inhibitor is beneficial
15. Use according to any one of claims 10,12 and 14, wherein said disorder or disease is an
affective disorder.
16. Use according to claim 15, wherein the affective disorder is a depressive disorder such
as major depressive disorder, postnatal depression, dysthymia or depression associated
with bipolar disorder, alzheimers, psychosis or parkinsons.
17. Use according to claim 15, wherein the affective disorder is an anxiety disorder such as
general anxiety disorder, social anxiety disorder, posttraumatic stress disorder,

obsessive compulsive disorder, panic disorder, panic attacks, specific phobias, social phobia and agoraphobia.
1S. Use according to any one of claims 12 and 14, wherein said disorder or disease is a pain disorder such as fibromyalgia syndrome, overall pain, back pain, shoulder pain, headache as well as pain while awake and during daily activities.
19. Use according to any one of claims 12 and 14, wherein said disorder or disease is
attention deficit hyperactivity disorder.
20. Use according to any one of claims 4 and 6, wherein said disorder or disease is stress
urinary incontinence.


Documents:

2275-CHENP-2006 AMENDED PAGES OF SPECIFICATION 06-09-2011.pdf

2275-CHENP-2006 AMENDED CLAIMS 06-09-2011.pdf

2275-CHENP-2006 CORRESPONDENCE OTHERS 30-09-2011.pdf

2275-CHENP-2006 OTHER PATENT DOCUMENT 06-09-2011.pdf

2275-CHENP-2006 POWER OF ATTORNEY 30-09-2011.pdf

2275-CHENP-2006 CORRESPONDENCE OTHERS 06-09-2011.pdf

2275-chenp-2006 correspondence others 25-01-2011.pdf

2275-CHENP-2006 CORRESPONDENCE OTHERS.pdf

2275-CHENP-2006 CORRESPONDENCE PO.pdf

2275-CHENP-2006 FORM-13 07-08-2008.pdf

2275-CHENP-2006 FORM-18.pdf

2275-CHENP-2006 FORM-3 06-09-2011.pdf

2275-chenp-2006-abstract.pdf

2275-chenp-2006-claims.pdf

2275-chenp-2006-correspondnece-others.pdf

2275-chenp-2006-description(complete).pdf

2275-chenp-2006-form 1.pdf

2275-chenp-2006-form 26.pdf

2275-chenp-2006-form 3.pdf

2275-chenp-2006-form 5.pdf

2275-chenp-2006-pct.pdf


Patent Number 250470
Indian Patent Application Number 2275/CHENP/2006
PG Journal Number 02/2012
Publication Date 13-Jan-2012
Grant Date 04-Jan-2012
Date of Filing 22-Jun-2006
Name of Patentee H. LUNDBECK A/S
Applicant Address Ottiliavej 9, DK-2500 Valby - Copenhagen
Inventors:
# Inventor's Name Inventor's Address
1 KEHLER, Jan Nymollevej 28, DK-2800 Lyngby
2 JUHL, Karsten Brydeholm 56, DK-2670 Greve
3 SEJBERG, Jimmy Overdrevet 4, DK-4623 Lille Skensved
4 NØRGAARD, Morten, Bang Buddingevej 130A, DK-2800 Lyngby
5 NORGAARD, Morten, Bang Buddingevej 130A, DK-2800 Lyngby
PCT International Classification Number C07D209/30,A61k31/404
PCT International Application Number PCT/DK2004/000894
PCT International Filing date 2004-12-21
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 PA 200301923 2003-12-23 Denmark