Title of Invention

"A PHENOXY CARBOXYLIC ACID COMPOUND OF FORMULA (1)"

Abstract

A phenoxy carboxylic acid compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3bor R4aand R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)1 (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or NH; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof

Full Text

PPAR Activating Compound and Pharmaceutical Composition Containing Same BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to a PPAR activating compound which selectively activates, among peroxisome proliferator-activated receptors (PPARs), a-type PPAR (i.e., PPARa), and is useful as a drug for preventing and/or treating pathological conditions including hyperlipidemia, arteriosclerosis, diabetes, complications of diabetes, inflammation, and heart diseases. The invention also relates to a pharmaceutical composition containing the compound. Background Art PPARs are known to form a family of nuclear receptors, and three sub-types thereof (a, y, 8) have already been identified (Nature, 347, 645-650, 1990; Cell, 68, pp. 879-887, 1992; Cell, 97, pp. 161-163, 1999; Biochim. Biophys. Acta., 1302, pp. 93-109, 1996; and Journal of Medicinal Chemistry, 43, pp. 527-550, 2000). Among the three sub-types, PPARot is expressed predominantly in the liver and is known to be activated by plasticizeres and/or fibrates, such as Wy 14643, clofibrate, fenofibrate, bezafibrate, or gemfibrosil (Journal of the National Cancer Institute, 90, 1702-1709, 1998, Current Opinion in Lipidology, 10, pp. 245-257, 1999). In mammals, activation of PPARa is known to promote (3 oxidation of fatty acids and lower the blood triglyceride level. In humans, activation of PPARoc decreases levels of blood lipids such as low-density lipoprotein (LDL) cholesterol and very low-density lipoprotein (VLDL) cholesterol. Thus, a PPARa-activator is useful as a drug for preventing and/or treating a disease such as hyperlipidemia. In addition, the PPARa-activator, is considered to be useful as a drug for preventing and/or treating pathological conditions such as arteriosclerosis due to increase the high density lipoprotein (HDL) cholesterol and the suppression of VCAM-1(one of cell adhesion molecules). Furthermore, the PPARa-activator is considered to be useful as a drug for preventing and/or treating pathological conditions such as diabetes, inflammatory disease, and heart diseases (Journal of Atherosclerosis and Thrombosis, 3, pp. 81-89, 1996; Current Pharmaceutical Design, 3, pp. 1-14, 1997; Current Opinion in Lipidology, 10, pp. 151-159, 1999; Current Opinion in Lipidology, 10, pp. 245-257, 1999; The Lancet, 354, pp. 141-148, 1999; Journal of Medicinal Chemistry, 43, pp. 527-550, 2000; and Journal of Cardiovascular Risk, 8, pp. 195-201, 2001). PPARy, which is expressed predominantly in adipocytes, is known to play an important role in differentiating and proliferating adipocytes. Examples of known activators for PPARy include thiazolidine derivative drugs such as troglitazone, pioglitazone, and rosiglitazone. These drugs are known to transform to fully-differentiated adipocytes having reduced insulin sensitivity into small adipocytes having high insulin sensitivity, to thereby improve insulin resistance (Journal of Biological Chemistry, 270, 12953-12956, 1995; Endocrinology, 137, pp. 4189-4195, 1996; Trends Endocrinol. Metab., 10, pp. 9-13, 1999; and J. Clin. Invest., 101, pp. 1354-1361, 1998). However, activation of PPARy has been reported to have adverse effects on human to increase fat and body weight and causing obesity (The Lancet, 349, pp. 952, 1997). Recently, it has also been reported that antagonize the PPARy possibly improves insulin resistance (Proc. Natl. Acad. Sci., 96, pp. 6102-6106, 1999; The Journal of Biological Chemistry, 275, pp. 1873-1877, 2000; and J. Clin. Invest., 108, 1001-1013, 2001). PPAR8, which is present ubiquitously in the body, is known to take part in the lipid metabolism. However, only a few highly selective PPARS activators have been reported, and the biological significance of PPAR5 remains unclear. At present, the structures of PPAR8 activators are reported in a wide range of literature (Diabetes, 46, 1319-1327, 1997; and Journal of Medicinal Chemistry, 43, pp. 527-550, 2000). In a recent report, a PPAR8 activator GW 501516 elevates HDL level in monkeys (Proc. Natl. Acad. Sci., 98, pp. 5306-5311, 2001). Moreover, adipocytes or skeletal muscle cells which are expressed activated PPAR8 are reported to promote burning of fat (Cell, 113, pp. 159-170, 2003) . However, a compound F, a PPARS activator, disclosed in WO 97/28149 has an unfavorable effect of accumulating lipids in human macrophages (Journal of Biological Chemistry, 276, pp. 44258-44265, 2001). In addition, experiments using PPAR8-deficient mice indicate that activation of PPAR8 induces lipid accumulation (Proc. Natl. Acad. Sci., 99, pp. 303-308, 2002). These phenomena represent two conflicting effect in terms of the progress and alleviation of arteriosclerosis. Thus, the significance of PPAR6 on treatment of arteriosclerosis still remains unelucidated. As described above, a PPARa-selective activator having low selectivity to PPARy and to PPAR8 is expected to be useful for preventing and/or treating, without causing obesity or increase in body weight, pathological conditions such as hyperlipidemia, arteriosclerosis, diabetes, complications of diabetes, inflammation, and heart diseases. WO 02/46176 discloses a PPAR activator having a structure represented by the following formula: (Figure Removed) wherein each of RI and R2 represents a hydrogen atom, a halogen atom, a nitro group, a C1-C8 alkyl group, a C1-C8 alkoxy group, or a C6-C10 aryl group, or RI and R2, together with the carbon atoms to which they are bonded, may form a benzene ring; X represents an oxygen atom, a sulfur atom, -(Ro represents a hydrogen atom or a C1-C8 alkyl roup), or -CH=CH-; G represents a single bond or a carbonyl group; R3 represents a C1-C8 alkyl group, a C2-C8 alkenyl group, a C2-C8 alkynyl group, a C3-C7 cycloalkyl group, a C1-C8 alkyl group substituted by a C3-C7 cycloalkyl group, a C6-C10 aryl group, an arylalkyl group (formed of a C6-C10 aryl moiety, with an alkyl moiety having 1 to 8 carbon atoms), a heterocyclic group, or a heterocyclicalkyl group (containing an alkyl moiety having 1 to 8 carbon atoms); n is an integer of 0 to 5; Y represents -CH2-, a carbonyl group, or -CH=CH-; Z represents an oxygen atom or a sulfur atom; p represents an integer of 0 to 5; each of R4 and R5 represents a hydrogen atom or a C1-C8 alkyl group; and W represents a carboxyl group, a C2-C8 alkoxycarbonyl group, a sulfonic acid group, a phosphonic acid group, a cyano group, or a tetrazolyl group). WO 04/00762 discloses a PPAR activator having a (Figure Removed) structure represented by the following formula: (wherein each of RI and R2 represents a hydrogen atom or a C1-C3 alkyl group; X represents a single bond, CH2, or an oxygen atom; each of R3 and R4 represents a hydrogen atom, a C1-C6 alkyl group, -OCH3-, -CF3, an allyl group, or a halogen atom; Xi represents CH2, S02, or C=0; R5 represents a C1-C6 alkyl group (which may be substituted by a C1-C6 alkoxy group or a C1-C6 alkylthio group), a C2-C6 alkenyl group, a CO-C6 alkylphenyl group (the phenyl group may have one or more substituents selected from among CF3, halogen atoms, C1-C3 alkyl groups, and C1-C3 alkoxy groups), -CO-(C1-C6 alkyl) group, or -S02-(C1-C6 alkyl) group; and R6 represents a phenyl group or a 6-membered heteroaryl group containing one to three nitrogen atoms (the phenyl group and the heteroaryl group may be substituted by one to three functional groups selected from among C1-C6 alkyl groups, halogen atoms, -0-(C1-C6 alkyl) groups, -SC>2- (C1-C3 alkyl) groups, and a phenyl group (which may be substituted by one or more functional groups selected from among halogen atoms, CF3, C1-C3 alkyl groups, -0-(C1-C3 alkyl) groups, an acetyl group, and a nitrile group)). However, the compounds disclosed in WO 02/46176 act on any sub-type of PPARs (i.e., PPARa, PPARy, and PPAR5) , and thus are not regarded as PPARa-selective activators, whereas the compounds disclosed in WO 04/00762 are described to be preferably PPAR5-selective, and in consideration that no test data are provided therein, the compounds cannot regarded as being PPARot-selective. SUMMARY OF THE INVENTION The present inventors have carried out extensive studies in order to obtain a compound which selectively activates a-type PPAR among other PPARs, and have found that a compound represented by the following formula (1) selectively activates PPARa and is useful as a drug for preventing and/or treating, without causing obesity or increase in body weight, pathological conditions including hyperlipidemia, arteriosclerosis, diabetes, complications of diabetes, inflammation, and heart diseases. The present invention has been accomplished on the basis of this finding. An object of the present invention is to provide a compound which selectively activates PPARa and a drug containing the compound. Accordingly, the present invention provides a compound represented by the following formula (1): (Figure Removed) (wherein each of RI and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, Rsb, FUa/ and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a Ci_4 alkyl group, a trif luoromethyl group, a Ci_4 alkoxy group, a Ci-4 alkylcarbonyloxy group, a di-Ci-4 alkylamino group, a Ci-4 alkylsulf onyloxy group, a Ci-4 alkylsulf onyl group, a C1_4 alkylsulf inyl group, or a C1_4 kylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N-R5 (R5 represents a hydrogen atom, a Ci_4 alkyl group, a d-4 alkylsulfonyl group, or a Ci-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(0)i (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, NH; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof. The present invention also provides a drug comprising, as an active ingredient, a compound represented by the above formula (1) or a salt thereof. The present invention also provides a therapeutic drug for hyperlipidemia comprising, as an active ingredient, a compound represented by the above formula (1) or a salt thereof. The present invention also provides a therapeutic drug for diabetes comprising, as an active ingredient, a compound represented by the above formula (1) or a salt thereof. The present invention also provides a therapeutic drug for complications of diabetes comprising, as an active ingredient, a compound represented by the above formula (1) or a salt thereof. The present invention also provides a therapeutic drug for inflammation comprising, as an active ingredient, a compound represented by the above formula (1) or a salt thereof. The present invention also provides a therapeutic drug for heart diseases comprising, as an active ingredient, a compound represented by the above formula (1) or a salt thereof. The present invention also provides a pharmaceutical composition comprising a compound represented by the above formula (1) or a salt thereof and a pharmacologically acceptable carrier. The present invention also provides the use, for producing a drug, of a compound represented by the above formula (1) or a salt thereof. The present invention also provides a method for treating a disease selected from the group consisting of hyperlipidemia, arteriosclerosis, diabetes, complications of diabetes, inflammation and heart diseases, which comprises administering an effective amount of a compound represented by the above formula (1) or a salt thereof to a subject in need. The compounds of the present invention provide a selective activation effect on PPARoc among other PPARs and are useful as therapeutic drugs for preventing and/or treating, without inviting increase in body weight or obesity, pathological conditions such as hyperlipidemia, arteriosclerosis, diabetes, complications of diabetes, inflammation, and heart diseases. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 shows activation factor of the compound of Example 1 with respect to each isoform of PPARs. Fig. 2 shows activation factor of the compound of Example 2 with respect to each isoform of PPARs. Fig. 3 shows activation factor of compound A with respect to each isoform of PPARs. Fig. 4 shows activation factor of compound B with respect to each isoform of PPARs. Fig. 5 shows activation factor of compound C with respect to each isoform of PPARs. DETAILED DESCRIPTION OF THE INVENTION As is evident from the formula (1), the compounds of the present invention are characterized by having a structure where a group: is bonded to a nitrogen atom. Until the present invention, the fact that a compound having the above described structure selectively activates PPARa has remained unknown. When Raa, Rab? R4a/ or R4b in formula (1) is a halogen atom, the halogen atom may be fluorine, chlorine, or bromine, with fluorine and chlorine being preferred. When R3a, R3b, R4a, R4b, or R5 is a Ci_4 alkyl group, the alkyl group may be methyl, ethyl, n-propyl, isopropyl, or butyl. Of these, methyl is particularly preferred. When R3a, R3b, R4a, or R4b is a Ci_4 alkoxy group, the alkoxy group may be methoxy, ethoxy, n-propoxy, isopropoxy, or butoxy. Of these, methoxy is particularly preferred. When R3a, R3b, Riar or R4b is a Ci_4 alkylcarbonyloxy group, the alkylcarbonyloxy group may be methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, isopropylcarbonyloxy, or butylcarbonyloxy. Of these, methylcarbonyloxy is particularly preferred. When R3a, R3b, R4a? °r ^4b is a di-Ci_4 alkylamino group, the dialkylamino group may be dimethylamino, diethylamino, or diisopropylamino. Of these, dimethylamino is particularly preferred. When R3a, R3b, R4a, or R4b is a Ci-4 alkylsulfonyloxy group, the alkylsulfonyloxy group may be methylsulfonyloxy or ethylsulfonyloxy. Of these, methylsulfonyloxy is particularly preferred. When R3a, R3b, R4a, R4b, or R5 is a Ci_4 alkylsulfonyl group, the alkylsulfonyl group may be methylsulfonyl or ethylsulfonyl. Of these, methylsulfonyl is particularly preferred. When R3a, R3b, R4a, or R4b is a Ci_4 alkylsulfinyl group, the alkylsulfinyl group may be methylsulfinyl or ethylsulfinyl. Of these, methylsulfinyl is particularly preferred. When R3a, R3b, R4a, or R4b is a Ci-4 alkylthio group, the alkylthio group may be methylthio or ethylthio. Of these, methylthio is particularly preferred. Examples of the alkylenedioxy group which is formed by linking R3a with R3b or by linking R4a with R4b include methylenedioxy and ethylenedioxy. Of these, methylenedioxy is particularly preferred. When R5 is a Ci-4 alkyloxycarbonyl group, the alkyloxycarbonyl group may be methyloxycarbonyl or ethyloxycarbonyl. Of these, methyloxycarbonyl is particularly preferred. In relation to RI and R2, the following cases are particularly preferred: they are both hydrogen atoms; they are both methyl groups; one is a methyl group and the other is a hydrogen atom; or one is an ethyl group and the other is a hydrogen atom. X represents an oxygen atom, a sulfur atom, or N-R5, with an oxygen atom being preferred. Y represents an oxygen atom, S(0)i, a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or NH. Of these, an oxygen atom is preferred. Z represents CH or N, with CH being preferred. 1 is a number of 0 to 2, with a number of 2 being preferred, n is a number of 1 to 6, with a number of 1 to 3 being preferred, m is a number of 2 to 6, with a number of 2 to 4 being preferred, and 2 or 3 being particularly preferred. Examples of the salts of the compounds represented by formula (1) of the present invention include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; organic base salts such as ammonium salts and trialkylamine salts; mineral acid salts such as hydrochloric acid salts and sulfuric acid salts; and organic acid salts such as acetic acid salts. The compound of the present invention may take the form of a solvate such as a hydrate or a geometrical (cis, trans) isomer or an optical isomer. These isomers also fall within the scope of the present invention. Among the compounds of the present invention, examples of compounds which are preferred due to their high PPARa selectivities include the following compounds or salts thereof: 2-[3-[[N- (benzoxazol-2-yl)-N-3-(4- fluorophenoxy)propyl)aminomethyl]phenoxy]butyric acid, 2-[3-[[N- (benzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl)aminoethyl]phenoxy]butyric acid, 2-[3-[[N- (benzoxazol-2-yl)-N-2-(4- fluorophenoxy)ethyl)aminoethyl]phenoxy]butyric acid, 2-[3-[[N- (benzoxazol-2-yl)-N-3- phenoxypropyl)aminomethyl]phenoxy]propionic acid, 3-[[N-(benzoxazol-2-yl)-N-3- phenoxypropyl)aminomethyl]phenoxyacetic acid, 2-[3-[[N- (benzoxazol-2-yl)-N-3- phenoxypropyl)aminomethyl]phenoxy]butyric acid, 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl)aminomethyl)phenoxy)butyric acid, 2-[3-[ [N- (benzoxazol-2-yl) -A/-3- (4- methoxyphenoxy)propyl)aminomethyl]phenoxy]propionic acid, The compounds of the present invention can be obtained in accordance with, for example, the following production methods described in reaction schemes A to K. (in the following schemes, RI, R2, Raa, Rab, R4a/ R4b, R$, m, n, X, Y, and Z have the same meanings as described above; Rg represents a substituent which can protect hydroxyl groups such as a Ci_4 alkyl group and a trialkylsilyl group (see, for example, "Protective Groups in Organic Synthesis (John Wiley & Sons, Inc.)"); RI represents a Ci_4 alkyl group; Rj represents R^a and R^; R4 represents R4a and R4b; Hal represents a halogen atom; and p is 1 or 2). The production method represented by reaction scheme A includes the following steps: A phenol compound (a) is reacted with 2-haloalkylcarboxylic acid ester (b), to thereby produce an aldehyde compound (c); the aldehyde compound (c) is reacted with an amine compound, followed by reduction; the thus-obtained amino compound (d) is reacted with 2- halobenzoxazole, to thereby produce an ester compound (e); and the ester compound (e) is subjected to hydrolysis, to thereby produce the compound (la) of the present invention. The first step (A-l) proceeds as follows. A phenol compound (a) is dissolved in a solvent such as N, N-dimethylformamide (DMF), tetrahydrofuran (THF), dioxane, or acetonitrile. A necessary amount of an inorganic base such as potassium carbonate (K2C03) , sodium carbonate (Na2C03) , or cesium carbonate (Cs2COs) or an organic base such as triethylamine or diisopropylethylamine is added thereto. Further, a necessary amount of a 2-haloalkylcarboxylic acid ester (b) such as 2-bromoisobutyric acid ester, 2-bromo-n-butyric acid ester, or 2-bromopropionic acid ester is added, and the resultant mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The ester is appropriately selected from among tert-butyl esters, ethyl esters, methyl esters, etc. In the second step (A-2), the aldehyde compound (c) is dissolved in a solvent such as 1,2-dichloroethane, chloroform, dichloromethane, DMF, THF, dioxane, or acetonitrile. Subsequently, a suitably selected amine compound and an acid such as acetic acid are added, followed by reduction with a reducing agent such as sodium triacetoxyborohydride (NaBH(OAc)3) . The reaction is carried out by stirring the mixture under cooling or at room temperature for several hours to 24 hours (in an inert gas atmosphere, if necessary). The third step (A-3) proceeds as follows. The starting amino compound (d) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. 2-Halobenzoxazole such as 2-chlorobenzoxazole is added thereto in the presence of a necessary amount of an inorganic base such as K2C03, Na2C03, or Cs2CC>3 or an organic base such as triethylaraine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours (in an inert gas atmosphere, if necessary). The fourth step (A-4) proceeds as follows. In the case where a methyl ester, ethyl ester, or any ester that is easily hydrolyzed with an alkali is used in the first step, the resultant ester compound which serves as the starting compound of the fourth step is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling, or between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. On the other hand, in the case where a tert-butyl ester or any ester that is easily decomposed by an acid is used in the first step, the resultant ester compound which serves as the starting compound of the fourth step is dissolved in a solvent such as dichloromethane or chloroform, followed by addition of an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. Reaction scheme B (Figure Removed) he production method represented by reaction scheme B includes the following steps: The starting carboxylic acid (f) is reacted with an amine, to thereby produce an amidophenol compound (g); the amidophenol compound (g) is reacted with a 2-haloalkylcarboxylic acid ester (b), to thereby produce an amide compound (h); the amide compound (h) is chemically reduced to thereby produce a secondary amino compound (i); the secondary amino compound (i) is reacted with 2-halobenzoazole, to thereby produce an ester compound (j); and the ester compound (j) is subjected to hydrolysis, to thereby produce the compound (Ib) of the present invention, The first step (B-l) proceeds as follows. The starting carboxylic acid (f) is dissolved in a solvent such as N,N- dimethylformamide (DMF), tetrahydrofuran (THF), dioxane, acetonitrile, or a mixture of solvents suitably selected therefrom. A suitably selected amine is dissolved in the solvent, and a necessary amount of a condensing agent such as dicyclohexylcarbodiimide or water-soluble carbodiimide (WSC • HC1) (e.g., l-ethyl-3-(3-dimethylaminopropyl)carbodiimide HC1) is added to the mixture under cooling. Subsequently, according to needs, a compound such as 1-hydroxy-lH-benztriazole (HOBt) or dimethylaminopyridine is added. The resultant mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent for several hours to 24 hours. The second step (B-2) proceeds as follows. The phenol compound (g) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. A necessary amount of an inorganic base such as K2C03, Na2C03, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine is added thereto. Subsequently, a necessary amount of a 2-haloalkylcarboxylic acid ester such as 2-bromoisobutyric acid ester, 2-bromo-n-butyric acid ester, or 2-bromopropionic acid ester is added, and the resultant mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The ester is appropriately selected from among tert-butyl esters, ethyl esters, methyl esters, etc. The third step (B-3) proceeds as follows. The starting amide compound (h) is dissolved in a solvent such as THF or dioxane. Subsequently, if necessary, in an inert gas atmosphere, a necessary amount of a reducing agent such as borane tetrahydrofuran complex (BH3-THF) is added thereto, and the reaction mixture is stirred at room temperature or under heating for several hours to 24 hours. The fourth step (B-4) proceeds as follows. The starting secondary amino compound (i) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. 2-Halobenzoazole such as 2-chlorobenzoxazole is added thereto in the presence of a necessary amount of an inorganic base such as K2C03, Na2C03, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours (in an inert gas atmosphere, if necessary). The fifth step (B-5) proceeds as follows. In the case where a methyl ester, ethyl ester, or any ester that is easily hydrolyzed with an alkali is used in the second step, the resultant ester compound which serves as the starting compound of the fifth step is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling, or between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. On the other hand, in the case where a tert-butyl ester or any ester that is easily decomposed by an acid is used in the second step, the resultant ester compound which serves as the starting compound of the fifth step is dissolved in a solvent such as dichloromethane or chloroform, followed by addition of an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. Reaction scheme C The production method represented by reaction scheme C (Figure Removed) includes the following steps: A carboxylic acid (k) is reacted with an amine, to thereby produce an amide compound (1); the hydroxyl-protective group is removed from the amide compound (1), to thereby produce a phenol compound (g) ; the phenol compound (g) is reacted with 2-haloalkylcarboxylic acid ester; the resultant compound is reduced to thereby produce an amino compound (i); the amino compound (i) is reacted with 2-halobenzoazole; and the resultant compound is subjected to hydrolysis, to thereby produce the compound of the present invention. The first step (C-l) proceeds as follows. The starting carboxylic acid (k) is dissolved in a solvent such as N, N-dimethylformamide (DMF), tetrahydrofuran (THF), dioxane, acetonitrile, or a mixture of solvents suitably selected therefrom. A suitably selected amine is dissolved in the solvent, and a necessary amount of a reagent such as dicyclohexylcarbodiimide or WSC • HC1 is added to the mixture under cooling. Subsequently, according to needes, a compound such as HOBt or dimethylaminopyridine is added. The resultant mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent for several hours to 24 hours. The second step (C-2) proceeds as follows. The amide compound (1) prepared in the first step is dissolved in a solvent such as dichloromethane, chloroform, or chlorobenzene. Thereafter, a Lewis acid such as boron tribromide or aluminum chloride is added thereto, and the mixture is stirred under cooling or at around the boiling point of the solvent for several hours to 24 hours. If Re = H, the reaction in the second step is not required. The third step (C-3) proceeds as follows. The phenol compound (g) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. A necessary amount of an inorganic base such as potassium carbonate (K2CC>3) , sodium carbonate (Na2CC>3), or cesium carbonate (CS2C03) or an organic base such as triethylamine or diisopropylethylamine is added thereto. Subsequently, a necessary amount of a 2-haloalkylcarboxylic acid ester such as 2-bromoisobutyric acid ester, 2-bromo-n-butyric acid ester, or 2-bromopropionic acid ester is added, and the resultant mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The ester is appropriately selected from among tert-butyl esters, ethyl esters, methyl esters, etc. The fourth step (C-4) proceeds as follows. The starting amide compound (h) is dissolved in a solvent such as THF or dioxane. Subsequently, if necessary, in an inert gas atmosphere, a necessary amount of a reducing agent such as borane tetrahydrofuran complex (BH3-THF) is added thereto, and the reaction mixture is stirred at room temperature or under heating for several hours to 24 hours. The fifth step (C-5) proceeds as follows. The starting amino compound (i) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. 2-Halobenzoazole such as 2-chlorobenzoxazole is added thereto in the presence of a necessary amount of an inorganic base such as K2C03, Na2C03, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours (in an inert gas atmosphere, if necessary). The sixth step (C-6) proceeds as follows. In the case where a methyl ester, ethyl ester, or any ester that is easily hydrolyzed with an alkali is used in the third step, the resultant ester compound which serves as the starting compound of the sixth step is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling, or between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. On the other hand, in the case where a tert-butyl ester or any ester that is easily decomposed by an acid is used in the third step, the resultant ester compound which serves as the starting compound of the sixth step is dissolved in a solvent such as dichloromethane or chloroform, followed by addition of an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. Reaction scheme D (Figure Removed) The production method represented by reaction scheme D includes the following steps: A phenol compound (m) is reacted with a 2-haloalkylcarboxylic acid ester, to thereby produce a cyano compound (n); the cyano compound (n) is reduced to thereby produce an amino compound (o); the amino compound (o) is reacted with 2-halobenzoazole, to thereby produce an amino compound (p); and the amino compound (p) is reacted with a halide; and the reaction compound is subjected to hydrolysis, to thereby produce the compound (Ib) of the present invention. The first step (D-l) proceeds as follows. A phenol compound (m) is dissolved in a solvent such as N, N-dimethylformamide (DMF), tetrahydrofuran (THF), dioxane, or acetonitrile. A necessary amount of an inorganic base such as potassium carbonate (K2CC>3) , sodium carbonate (Na2CC>3) , or cesium carbonate (Cs2CC>3) or an organic base such as triethylamine or diisopropylethylamine is added thereto. Subsequently, a necessary amount of a 2-haloalkylcarboxylic acid ester such as 2-bromoisobutyric acid ester, 2-bromo-n-butyric acid ester, or 2-bromopropionic acid ester is added, and the resultant mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The ester is appropriately selected from among tert-butyl esters, ethyl esters, methyl esters, etc. The second step (D-2) proceeds as follows. The starting cyano compound (n) is dissolved in a solvent such as THF or dioxane. Subsequently, if necessary, in an inert gas atmosphere, a necessary amount of a reducing agent such as borane tetrahydrofuran complex (BHa'THF) is added thereto, and the reaction mixture is stirred at room temperature or under heating for several hours to 24 hours. The third step (D-3) proceeds as follows. The starting amino compound (o) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. 2-Halobenzoazole such as 2-chlorobenzoxazole is added thereto in the presence of a necessary amount of an inorganic base such as K2C03, Na2C03, or Cs2C03 or an organic base such as triethylamine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours (in an inert gas atmosphere, if necessary). The fourth step (D-4) proceeds as follows. The starting amino compound (p) is dissolved in an inert solvent such as DMF, THF, dioxane, or acetonitrile. A suitably selected halide is added thereto in the presence of a necessary amount of an inorganic base such as F^COs, Na2COs, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The fifth step (D-5) proceeds as follows. In the case where a methyl ester, ethyl ester, or any ester that is easily hydrolyzed with an alkali is used in the first step, the resultant ester compound which serves as the starting compound of the fifth step is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling, or between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. On the other hand, in the case where a tert-butyl ester or any ester that is easily decomposed by an acid is used in the first step, the resultant ester compound which serves as the starting compound of the fifth step is dissolved in a solvent such as dichloromethane or chloroform, followed by addition of an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. Reaction scheme E (Figure Removed) The production method represented by reaction scheme E includes the following steps: The starting carboxylic acid (k) is reacted with ammonia or an annmonium salt, to thereby produce an amide compound (q); the hydroxyl-protective group is removed from the amide compound (q), to thereby produce a phenol compound (r); the pnenol copmpound (r) is reacted with 2-haloalkylcarboxylic acid ester, to thereby produce an amide compound (S); the amide compound (s) is reduced to thereby produce an amino compound (t); the amino compound (t) is reacted with 2-halobenzoazole, to thereby produce an amino compound (p); the amino compound (p) is reacted with a halide, to thereby produce an amino compound (j); and the amino compound (j) is subjected to hydrolysis, whereby the compound (Ib) of the present invention is obtained. The first step (E-l) proceeds as follows. The starting carboxylic acid (k) is dissolved in a solvent such as N,N-dimethylformamide (DMF), tetrahydrofuran (THF), dioxane, acetonitrile, or a mixture of solvents suitably selected therefrom. An inorganic base such as potassium carbonate (K2C03) , sodium carbonate (Na2CC>3) , or cesium carbonate (CS2C03) or an organic base such as triethylamine, diisopropylethylamine, or pyridine is added thereto. An anhydride such as ditert-butyl dicarbonate is added to the mixture, followed by stirring for several minutes to 3 hours under cooling or at room temperature. Ammonia or an ammonium salt (e.g., ammonium hydrogencarbonate) is added thereto. The resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. The second step (E-2) proceeds as follows. The amide compound (q) prepared in the first step is dissolved in a solvent such as dichloromethane, chloroform, or chlorobenzene, as needed. Thereafter, a Lewis acid such as boron tribromide or aluminum chloride is added thereto, and the mixture is stirred under cooling or at around the boiling point of the solvent for several hours to 24 hours. If Re = H, the reaction in the second step is not required. The third step (E-3) proceeds as follows. The phenol compound (r) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. A necessary amount of an inorganic base such as F^COs, Na2COa, or CS2C03 or an organic base such as triethylamine or diisopropylethylamine is added thereto. Subsequently, a necessary amount of a 2-haloalkylcarboxylic acid ester such as 2-bromoisobutyric acid ester, 2-bromo-n-butyric acid ester, or 2-bromopropionic acid ester is added, and the resultant mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The ester is appropriately selected from among tert-butyl esters, ethyl esters, methyl esters, etc. The fourth step (E-4) proceeds as follows. The starting amide compound (s) is dissolved in a solvent such as THF or dioxane. Subsequently, if necessary, in an inert gas atmosphere, a necessary amount of a reducing agent such as borane tetrahydrofuran complex (BHs'THF) is added thereto, and the reaction mixture is stirred at room temperature or under heating for several hours to 24 hours. The fifth step (E-5) proceeds as follows. The starting amino compound (t) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. 2-Halobenzoazole such as 2-chlorobenzoxazole is added thereto in the presence of a necessary amount of an inorganic base such as K^COs, Na2CC>3, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours (in an inert gas atmosphere, if necessary). The sixth step (E-6) proceeds as follows. The starting amino compound (p) is dissolved in an inert solvent such as DMF, THF, dioxane, or acetonitrile. A suitably selected halide is added thereto in the presence of a necessary amount of an inorganic base such as K2CC>3, NaaCOa, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The seventh step (E-7) proceeds as follows. In the case where a methyl ester, ethyl ester, or any ester that is easily hydrolyzed with an alkali is used in the third step, the resultant ester compound which serves as the starting compound of the seventh step is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling, or between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. On the other hand, in the case where a tert-butyl ester or any ester that is easily decomposed by an acid is used in the third step, the resultant ester compound which serves as the starting compound of the seventh step is dissolved in a solvent such as dichloromethane or chloroform, followed by addition of an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. Reaction scheme F The production method represented by reaction scheme F includes the following steps: The starting aldehyde compound (u) is reacted with an amine compound, followed by reduction; the thus-obtained amino compound (v) is reacted with 2-halobenzoazole, to thereby produce the compound (w); the hydroxyl-protective group is removed from the compound (w), to thereby produce a phenol compound (x); the phenol compound is reacted with 2-hydroxycarboxylic acid ester, to thereby produce a compound (j); and the compound (j) is subjected to hydrolysis, to thereby produce the compound (Ib) of the present invention. The first step (F-l) proceeds as follows. The starting aldehyde compound (u) is dissolved in a solvent such as 1,2-dichloroethane, chloroform, dichloromethane, W, A/- (Figure Removed) dimethylformamide (DMF), tetrahydrofuran (THF), dioxane, or acetonitrile. Subsequently, a suitably selected amine compound and an acid such as acetic acid are added, followed by reduction with a reducing agent such as sodium triacetoxyborohydride (NaBH(OAc)3) . The reaction is carried out by stirring the mixture under cooling or at room temperature for several hours to 24 hours (in an inert gas atmosphere, if necessary). The second step (F-2) proceeds as follows. The amino compound (v) prepared in the first step is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. 2-Halobenzoazole such as 2-chlorobenzoxazole is added thereto in the presence of a necessary amount of an inorganic base such as K2CC>3, Na2C03, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine. The mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours (in an inert gas atmosphere, if necessary). The third step (F-3) proceeds as follows. In the case where R6 forms any ester (e.g., CH3CO-) that is easily hydrolyzed with an alkali, the compound (w) is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, potassium hydroxide, or potassium carbonate or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling or at a temperature between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is neutralized or acidified by use of an acid such as an aqueous ammonium chloride solution or diluted hydrochloric acid. In the case where the ester is easily decomposed by an acid, as in the case of an ester having a methoxymethyl moiety, the compound (w) is dissolved in a solvent such as dichloromethane or chloroform, and an acid such as hydrochloric acid is added to the solution, followed by stirring the mixture for several hours to 24 hours under cooling or at room temperature. In the case where R6 is a silyl group such as tert-butyldimethylsilyl, the compound (w) is dissolved in a solvent such as THF, dioxane, acetonitrile, dichloromethane, or chloroform, and a fluoride compound such as tetrabutylammonium fluoride is added to the solution, followed by stirring the mixture for several hours to 24 hours at a temperature between room temperature and around the boiling temperature of the solvent. In this case, the reaction may be performed by dissolving the compound (w) in a solvent such as DMF, ethanol, or methanol, adding a base such as potassium carbonate, cesium carbonate, or lithium hydroxide to the solution, and stirring the mixture for several hours to 24 hours at a temperature between room temperature and around the boiling point of the solvent. The fourth step (F-4) proceeds as follows. The phenol compound (x) obtained in the third step and a 2-hydroxycarboxylic acid ester such as tert-butyl 2- hydroxybutyrate or ethyl lactate are dissolved in a solvent such as THF, dioxane, acetonitrile, or toluene. Under the Mitsunobu reaction conditions, the solution is stirred at a temperature between room temperature and around the boiling point of the solvent for several hours to 24 hours. Alternatively, a 2-hydroxycarboxylic acid ester such as tert-butyl 2-hydroxybutyrate or ethyl lactate is dissolved in a solvent such as THF, dioxane, acetonitrile, toluene, or DMF. Subsequently, an inorganic base or an organic base such as triethylamine or diisopropylethylamine is added thereto. Subsequently, sulfonyl chloride such as methanesulfonyl chloride or p-toluenesulfonyl chloride is added thereto. The resultant mixture and the phenol compound (x) produced in the third step are mixed together, and the resultant mixture is stirred for several hours to 24 hours under ice-cooling or at a temperature between room temperature and around the boiling point of the solvent. The ester is appropriately selected from among tert-butyl esters, ethyl esters, methyl esters, etc. The fifth step (F-5) proceeds as follows. In the case where a methyl ester, ethyl ester, or any ester that is easily hydrolyzed with an alkali is used in the fourth step, the resultant ester compound which serves as the starting compound of the fifth step is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling or at a temperature between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. On the other hand, in the case where a tert-butyl ester or any ester that is easily decomposed by an acid is used in the fourth step, the resultant ester compound which serves as the starting compound of the fifth step is dissolved in a solvent such as dichloromethane or chloroform, followed by addition of an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. This synthesis route enables a successful synthesis of compounds (Ib), even when R6 is a hydrogen atom. In this case (R6 = H) , the process in the third step F-3 is not required. Reaction scheme G (Figure Removed) The production method represented by reaction scheme G includes the following steps: The compound (z) obtained in the course of reaction scheme A is oxidized; and the oxidized compound is subjected to hydrolysis, to thereby produce the compound (Ic) of the present invention. The first step (G-l) proceeds as follows. The compound (z) produced in the fourth step of reaction scheme A is dissolved in a solvent such as chloroform or dichloromethane. Subsequently, the compound (z) is oxidized by use of an peroxide such as m-chloroperbenzoic acid or H202 under stirring for several hours to 24 hours under cooling or at room temperature. The second step (G-2) proceeds as follows. In the case where R7 forms a methyl ester, an ethyl ester, or any ester that is easily hydrolyzed with an alkali, the ester compound is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling or at a temperature between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. In the case where R7 forms a tert-butyl ester or any ester that is easily decomposed by an acid, the ester compound is dissolved in a solvent such as dichloromethane or chloroform, and an acid such as trifluoroacetic acid is added to the solution, followed by stirring the mixture for several hours to 24 hours under cooling or at room temperature. o he production method represented by reaction scheme H includes the following steps: A halide (ab) is reacted with sodium azide, to thereby produce an azide compound (ac); the carbonyl moiety in the azide compound (ac) is protected with a compound such as acetal, to thereby produce an acetal compound (ad); the acetal compound (ad) is reduced to thereby produce an amine compound (ae); the amine compound (ae) is transformed into a compound (ag) in a manner similar to those described in reaction schemes (A-2) and (A-3); the compound (ag) is transformed into a keto compound (ah) through deprotection; and the keto compound (ah) is subjected to hydrolysis, to thereby produce the compound (Id) of the present invention. The first step (H-l) proceeds as follows. A halide (ab) is dissolved in a solvent such as N, W-dimethylformamide (DMF), dioxane, or acetonitrile. A necessary amount of sodium azide is added thereto, and the resultant mixture is stirred at a temperature between room temperature and around the boiling point of the solvent for several hours to 24 hours. The second step (H-2) proceeds as follows. The azide compound (ac) is dissolved in a solvent such as benzene, toluene, chloroform, or dichloromethane. In the presence of an acid catalyst such as p-toluenesulfonic acid or pyridinium p-toluenesulfonate (PPTS), the solution is reacted with ethylene glycol under stirring at a temperature between room temperature and around the boiling point of the solvent. The protective group with respect to the carbonyl moiety is not limited to an ethylenedioxy group, and a suitable alkanediol may be used to protect the carbonyl moiety. The third step (H-3) proceeds as follows. The acetal compound (ad) is dissolved in a mixture of a solvent such as THF or 1,4-dioxane and water or an aqueous solution of sodium hydroxide. A necessary amount of triarylphosphine such as triphenylphosphine is added thereto, and the mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The fourth step (H-4) can proceed in a manner similar to that described in the reaction scheme (A-2). The fifth step (H-5) can proceed in a manner similar to that described in the reaction scheme (A-3). The sixth step (H-6) proceeds as follows. The resultant compound (ag) obtained in the fifth step is dissolved in a solvent such as dioxane, THF, or acetone. A necessary amount of an acid such as PPTS or hydrochloric acid is added thereto, and the mixture is allowed to react at a temperature between room temperature and around the boiling point of the solvent under stirring for several hours to 24 hours. The seventh step (H-7) proceeds as follows. In the case where a methyl ester, ethyl ester, or any ester that is easily hydrolyzed with an alkali is used in the fourth step, the keto compound (ah) which serves as the starting compound of the seventh step is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling, or between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. On the other hand, in the case where a tert-butyl ester or any ester that is easily decomposed by an acid is used in the fourth step, the keto compound which serves as the starting compound of the seventh step is dissolved in a solvent such as dichloromethane or chloroform, followed by addition of an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. (Figure Removed) The production method represented by reaction scheme I includes the following steps: The aldehyde compound (c) produced in the reaction scheme (A-l) is reacted with an amino alcohol, and the reaction mixture is reduced to thereby produce an amino alcohol compound (ai); the amino alcohol compound (ai) is reacted with 2-halobenzoxazole, to thereby produce an alcohol compound (aj); potassium phthalimide is introduced into the alcohol compound (aj); the resultant compound is reacted with hydrazine, to thereby produce an amino compound (al); the amino compound (al) is transformed into a sulfonamide compound (am); the sulfonamide compound (am) is hydrolyzed; and the resultant compound is subjected to hydrolysis, to thereby produce the compound (le) of the present invention. The first step (1-1) proceeds as follows. The aldehyde compound (c) is dissolved in a solvent such as 1,2-dichloroethane, chloroform, dichloromethane, DMF, THF, dioxane, or acetonitrile. Subsequently, a suitably selected amino alcohol and an acid such as acetic acid are added, followed by reduction with a reducing agent such as sodium triacetoxyborohydride (NaBH(OAc)3) . The reaction is carried out by stirring the mixture under cooling or at room temperature for several hours to 24 hours (in an inert gas atmosphere, if necessary). The second step (1-2) proceeds as follows. The amino alcohol compound (ai) is dissolved in a solvent such as DMF, THF, dioxane, or acetonitrile. 2-Halobenzoxazole such as 2-chlorobenzoxazole is added thereto in the presence of a necessary amount of an inorganic base such as K2CC>3, Na2CC>3, or Cs2C03 or an organic base such as triethylamine or diisopropylethylamine. The reaction mixture is stirred at a temperature between room temperature and around the boiling point of the solvent for several hours to 24 hours (in an inert gas atmosphere, if necessary). The third step (1-3) proceeds as follows. The alcohol compound (aj) is dissolved in a solvent such as DMF, THF, dioxane, acetonitrile, or toluene. Subsequently, pottasium phthalimide is added thereto. Under the Mitsunobu reaction conditions, the mixture is stirred at a temperature between room temperature and around the boiling point of the solvent for several hours to 24 hours. The fourth step (1-4) proceeds as follows. The phthalimide compound (ak) is dissolved in a solvent such as methanol, ethanol, or isopropanol. Subsequently, hydrazine is added thereto, and the mixture is stirred at a temperature between room temperature and around the boiling point of the solvent for several hours to 24 hours. The fifth step (1-5) proceeds as follows. The amino compound (al) is dissolved in a solvent such as DMF, acetonitrile, 1,4-dioxane, THF, or chloroform. Arylsulfonyl chloride is added thereto in the presence of an organic base such as triethylamine or diisopropylethylamine or an inorganic base such as Na2C03, K2CC>3, or Cs2C03. The reaction mixture is stirred under cooling or at around the boiling point of the solvent for several hours to 24 hours. The sixth step (1-6) proceeds as follows. The sulfonamide compound (am) is dissolved in a solvent such as dichloromethane or chloroform. Subsequently, an acid such as trifluoroacetic acid, and the resultant mixture is stirred for several hours to 24 hours under cooling or at room temperature. The seventh step (1-7) proceeds as follows. The carboxylic acid compound (an) is dissolved in a solvent such as methanol, ethanol, or THF. Subsequently, a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto, and the mixture is stirred under cooling, or between room temperature and around the boiling point of the solvent for several hours to 24 hours. Reaction scheme J (Table Removed) The production method represented by reaction scheme J includes the following steps: The compound (v) produced in the reaction step F-l is reacted with 2-halo phenyl isothiocyanate, to thereby produce a thiourea compound (ao); the thiourea compound (ao) is reacted with palladium to thereby produce a benzothiazole compound (ap); the benzothiazole compound (ap) is transformed to a phenol compound (aq), which is then transformed to an ester compound (ar); and the ester compound (ar) is subjected to hydrolysis, to thereby produce the compound (If) of the present invention. The first step (J-l) proceeds as follows. The compound (v) produced in the reaction step F-l is dissolved in a solvent such as N, AJ-dimethylf ormamide (DMF), tetrahydrof uran (THF), dioxane, acetonitrile, or chloroform, and 2-halo phenyl isothiocyanate is added to the solution, followed by stirring the mixture for several hours to 24 hours under cooling or at room temperature. Examples of the halogen include bromine and iodine. The second step (J-2) proceeds as follows. The thiourea compound (ao) is dissolved in a solvent such as THF, dioxane, DMF, toluene, or dichloromethane, and a palladium catalyst such as Pd2(dba)3, Pd(Ph3P)4, or Pd(OAc)2 and, if necessary, a suitably selected ligand such as dppf, dppp, dppe, or Ph3P are added to the solution, followed by stirring the mixture for several hours to 24 hours at a temperature between room temperature and around the boiling point of the solvent (in an inert gas atmosphere, if necessary). The third step (J-3) proceeds as follows. In the case where R6 forms any ester (e.g., CH3CO-) that is easily hydrolyzed with an alkali, the compound (ap) is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, potassium hydroxide, or potassium carbonate or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling or at a temperature between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is neutralized or acidified by use of an acid such as an aqueous ammonium chloride solution or diluted hydrochloric acid. In the case where R6 forms a methoxymethyl ester or any ester that is easily decomposed by an acid, the compound (ap) is dissolved in a solvent such as dichloromethane or chloroform, and an acid such as hydrochloric acid is added to the solution, followed by stirring the mixture for several hours to 24 hours under cooling or at room temperature. In the case where Re is a silyl group such as tert-butyldimethylsilyl, the compound (ap) is dissolved in a solvent such as THF, dioxane, acetonitrile, dichloromethane, or chloroform, and a fluoride compound such as tetrabutylammonium fluoride is added to the solution, followed by stirring the mixture for several hours to 24 hours at a temperature between room temperature and around the boiling temperature of the solvent. In this case, the reaction may be performed by dissolving the compound (ap) in a solvent such as DMF, ethanol, or methanol, adding a base such as potassium carbonate, cesium carbonate, or lithium hydroxide to the solution, and stirring the mixture for several hours to 24 hours at a temperature between room temperature and around the boiling point of the solvent. The fourth step (J-4) proceeds as follows. The starting phenol compound (aq) is dissolved in a solvent such as DMF, THF, dioxane, acetonitrile, or toluene, and then reacted with a 2-hydroxycarboxylic acid ester such as a lactic acid ester or a 2-hydroxybutyric acid ester under the Mitsunobu reaction conditions. Alternatively, a leaving group such as a methanesulfonyl group or a p-toluenesulfonyl group is introduced to the starting phenol compound (aq), and the product is reacted with 2-hydroxylcarboxylic acid ester under stirring for several hours to 24 hours at a temperature between room temperature and around the boiling point of the solvent in the presence of an inorganic base such as Na2C03, K2CC>3, or CS2C03 or an organic base such as triethylamine or diisopropylethylamine. Alternatively, the starting phenol compound (aq) is dissolved in a solvent such as DMF, THF, dioxane, acetonitrile, or toluene, and the solution is reacted with a 2-halocarboxylic acid ester such as ethyl 2-bromopropionate or ethyl 2-bromobutyrate under stirring for several hours to 24 hours at a temperature between room temperature and around the boiling point of the solvent in the presence of an inorganic base such as Na2C03, K2C03, or Cs2CC>3 or an organic base such as triethylamine or diisopropylethylamine. The fifth step (J-5) proceeds as follows. In the case where R7 forms a methyl ester, an ethyl ester, or any ester that is easily hydrolyzed with an alkali, the ester compound is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling, or at a temperature between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. In the case where R7 forms a tert-butyl ester or any ester that is easily decomposed by an acid, the ester compound is dissolved in a solvent such as dichloromethane or chloroform, and an acid such as trifluoroacetic acid is added to the solution, followed by stirring the mixture for several hours to 24 hours under cooling or at room temperature. It should be noted that, when the reaction scheme J is employed, the target compound (If) can be produced from a starting compound (v) in which R6 is a hydrogen atom. In this case, the third step (J-3) is not required. Reaction scheme K (Figure Removed) The production method represented by reaction scheme K includes the following steps: An amino compound (d) obtained in the course of reaction scheme A is reacted with 2-nitrophenyl isocyanate, to thereby produce a nitro compound (as); the nitro compound is reduced to thereby produce an urea compound (at); the urea compound (at) is reacted with an acid to thereby produce an ester compound (au); if necessary, the ester compound (au) is reacted with a halide to thereby produce an N-substituted compound (av); and the compound (av) is hydrolyzed to thereby produce the compound (Ig) of the present invention. The first step (K-l) proceeds as follows. The amino compound (d) is dissolved in a solvent such as N, N-dimethylformamide (DMF), tetrahydrofuran (THF), dioxane, acetonitrile, or chloroform, and a necessary amount of 2-nitrophenyl isocyanate which may have a substituent is added to the solution, followed by stirring the mixture for several hours to 24 hours under cooling or at room temperature. The second step (K-2) proceeds as follows. The nitro compound (as) is dissolved in a solvent such as methanol, ethanol, ethyl acetate, or dioxane, and then reduced through use of a metal catalyst such as palladium carbon under hydrogen or in the presence of formic acid. The third step (K-3) proceeds as follows. The starting urea compound (at) is dissolved in a solvent such as chloroform or toluene, and the solution is stirred for several hours to 24 hours in the presence of a necessary amount of an acid such as phosphorus oxychloride, phosphorus trichloride, or phosphorus pentachloride at a temperature between room temperature and around the boiling temperature of the solvent. The fourth step (K-4) proceeds as follows. The ester compound (au) is dissolved in a solvent such as DMF, acetonitrile, 1,4-dioxane, or THF, and the solution is reacted with a haloalkane such as iodomethane, a sulfonylchloride such as methanesulfonyl chloride, or a similar compound under stirring for several hours to 24 hours under cooling or at a temperature around the boiling point of the solvent in the presence of an organic base such as triethylamine or diisopropylethylamine or an inorganic base such as Na2C03, K2C03, or Cs2C03. The fifth step (K-5) proceeds as follows. In the case where R7 forms a methyl ester, an ethyl ester, or any ester that is easily hydrolyzed with an alkali, the N-substituted compound (av) is dissolved in a solvent such as methanol, ethanol, or THF; a base such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, or an aqueous solution thereof is added thereto; and the mixture is allowed to react for several hours to 24 hours under cooling or at a temperature between room temperature and around the boiling point of the solvent. After completion of reaction, the reaction mixture is acidified by use of an acid such as hydrochloric acid. In the case where R? forms a tert-butyl ester or any ester that is easily decomposed by an acid, the compound (av) is dissolved in a solvent such as dichloromethane or chloroform, and an acid such as trifluoroacetic acid is added to the solution, followed by stirring the mixture for several hours to 24 hours under cooling or at room temperature. It should be noted that, when R5 is a hydrogen atom, the fourth step (K-4) is not required. The compounds according to the present invention can be produced through any of the aforementioned methods. The thus-obtained products may be purified in accordance with needs through a customary purification method such as recrystallization or column chromatography. The compounds may be converted to the aforementioned desired salts or solvates through a routine process, in accordance with needs. As described in relation to the below-mentioned Test Example, the thus-produced compounds of the present invention exert a selective activation effect on PPARa. Thus, these compounds are useful as a drug for preventing and/or treating pathological conditions of mammals (including humans) such as hyperlipidemia, arteriosclerosis, diabetes, complications of diabetes (e.g., diabetic nephropathy), inflammation, and heart diseases, without causing increase in body weight or obesity. The pharmaceutical of the present invention contains, as an active ingredient, the present compound (1) or a salt thereof. No particular limitation is imposed on the form of administration, and the administration form can be appropriately determined in accordance with the purpose of treatment, and selected from among, for examples, peroral solid forms, peroral liquid forms, injections, suppositories, external preparations, ophthalmic solutions, nasal drops, ear drops, and patches. These administration forms can be produced by mixing the active ingredient with a pharmacologically acceptable carrier and through any preparation methods known in the art. When an oral solid drug product is prepared, the present compound (1) is mixed with a diluent (and, if necessary, an additive such as a binder, a disintegrant, a lubricant, a coloring agent, a sweetening agent, or a flavoring agent), and the resultant mixture is processed through a routine method, to thereby produce an oral solid drug product such as tablets, granules, powder, or capsules. Such an additive may be an additive generally employed in the art. Examples of the diluent include lactose, sodium chloride, glucose, starch, microcrystalline cellulose, and silicic acid; examples of the binder include water, ethanol, propanol, simple syrup, liquefied gelatin, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, shellac, calcium phosphate, and polyvinyl pyrrolidone; examples of the disintegrant include agar powder, sodium hydrogencarbonate, sodium lauryl sulfate, and monoglyceryl stearate; examples of the lubricant include purified talc, stearate salt, borax, and polyethylene glycol; examples of the coloring agent include p-carotene, yellow iron sesquioxide, and caramel; and examples of the sweetening agent include saccharose and orange peel. When a liquid drug product for oral administration is prepared, the present compound (1) is mixed with an additive such as a sweetening agent, a buffer, a stabilizer, or a preservative, and the resultant mixture is processed through a routine method, to thereby produce an orally administered liquid drug product such as internal solution medicine, syrup, or elixir. Such an additive may be an additive generally employed in the art. Examples of the sweetening agent include saccharose; examples of the buffer include sodium citrate; examples of the stabilizer include tragacanth; and examples of the preservative include p-hydroxybenzoate ester. When an injection is prepared, the present compound (1) is mixed with an additive such as a pH regulator, a stabilizer, or an isotonicity agent, and the resultant mixture is processed through a routine method, to thereby produce an injection such as a subcutaneous injection, an intramuscular injection, or an intraveneous injection. Such an additive may be an additive generally employed in the art. Examples of the pH regulator include sodium phosphate; examples of the stabilizer include sodium pyrosulfite; and examples of the isotonicity agent include sodium chloride. When a suppository is prepared, the present compound (1) is mixed with an additive such as a carrier or a surfactant, and the resultant mixture is processed through a routine method, to thereby produce a suppository. Such an additive may be an additive generally employed in the art. Examples of the carrier include polyethylene glycol and hard fat, and examples of the surfactant include polysorbate 80. When an external drug product is prepared, the present compound (1) is mixed with an additive such as a base, a water-soluble polymer, a solvent, a surfactant, or a preservative, and the resultant mixture is processed through a routine method, to thereby produce external preparations such as liquids or solutions, creams, gels, or ointments. Examples of the base include liquid paraffin, white Vaseline, and purified lanolin; examples of the water-soluble polymer include carboxyvinyl polymer; examples of the solvent include glycerol and water; examples of the surfactant include polyoxyethylene fatty acid ester; and examples of the preservative include p-hydroxybenzoate ester. When an ophthalmic solution is prepared, the present compound (1) is mixed with an additive such as a pH regulator, a stabilizer, an isotonicity agent, or a preservative, and the resultant mixture is processed through a routine method, to thereby produce an ophthalmic solution. Such an additive may be an additive generally employed in the art. Examples of the pH regulator include sodium phosphate; examples of the stabilizer include sodium pyrosulfite and EDTA; examples of the isotonicity agent include sodium chloride; and examples of the preservative include chlorobutanol. When a nasal drop is prepared, the present compound (1) is mixed with an additive such as a pH regulator, a stabilizer, an isotonicity agent, or a preservative, and the resultant mixture is processed through a routine method, to thereby produce a nasal drop. Such an additive may be an additive generally employed in the art. Examples of the pH regulator include sodium phosphate; examples of the stabilizer include sodium pyrosulfite and EDTA; examples of the isotonicity agent include sodium chloride; and examples of the preservative include benzalkonium chloride. When an ear drop is prepared, the present compound (1) is mixed with an additive such as a pH regulator, a buffer, a stabilizer, an isotonicity agent, or a preservative, and the resultant mixture is processed through a routine method, to thereby produce an ear drop. Such an additive may be an additive generally employed in the art. Examples of the pH regulator and the buffer include sodium phosphate; examples of the stabilizer include sodium pyrosulfite and EDTA; examples of the isotonicity agent include sodium chloride; and examples of the preservative include benzalkonium chloride. When a patch is prepared, the present compound (1) is mixed with an additive such as a tackifier, a solvent, a cross linking agent, or a surfactant, and the resultant mixture is processed through a routine method, to thereby produce a patch such as a hydrated patch or plaster patch. Such an additive may be an additive generally employed in the art. Examples of the tackifier include partially neutralized poly(acrylic acid), sodium polyacrylate, poly(2-ethylhexylacrylate), and styrene-isoprene-styrene block copolymer; examples of the solvent include glycerol and water; examples of the cross linking agent include dihydroxyaluminum aminoacetate and dried aluminum hydroxide gel; and examples of the surfactant include polyoxyethylene fatty acid ester. The dose of the drug of the present invention differs depending on the age, body weight, and condition of the patient and the manner and frequency of administration, etc. The daily dose of the present compound (1) for an adult is typically 1 to 1,000 mg, and the drug is preferably administered perorally or parenterally once a day or several times a day in a divided manner. EXAMPLES The present invention will next be described in detail by way of examples, which should not be construed as limiting the invention. Production Example 1 Synthesis of Ethyl 2-(3-formylphenoxy)butyrate 3-Hydroxybenzaldehyde (18.3 g, 0.150 mol) was dissolved in N, A/-dimethylformamide (150 mL) . Subsequently, potassium carbonate (22.80 g, 0.165 mol), and then ethyl 2- bromobutyrate (29.26 g, 0.150 mol) were added thereto, and the resultant mixture was stirred overnight at 80°C. The temperature of the reaction mixture was returned to room temperature. Ethyl acetate was added. Washing was performed sequentially with water and brine, followed by drying over sodium sulfate. The reaction mixture was subjected to filtration, concentration under reduced pressure, and purification by silica gel column chromatography (n- hexane/ethyl acetate = 5/1), whereby a colorless oil was obtained (35.29 g, 0.149 mol, 99.6%). XH-NMR (400MHz,CDC13) 5: 1.10 ( t, J= 7Hz, 3H ), 1.26 ( t, J=7Hz, 3H), 1.99-2.06 (m, 2H), 4.23 (q, J=7Hz, 2H), 4.65 (t, J=6Hz, 1H), 7.17-7.22 (m, 1H), 7.35( s, 1H ), 7.45-7.49 (m, 2H), 9.95 ( s, 1H ). Production Example 2 Synthesis of Ethyl 2- [3- [A7- [3- ( 4- fluorophenoxy)propyl]aminomethyl]phenoxy]butyrate (Figure Removed) Ethyl 2-(3-formylphenoxy) butyrate (5.0 g, 21.2 mmol) was dissolved in 1,2-dichloroethane (20 mL) . Subsequently, 3-(4-fluorophenoxy)propylamine (4.65 g, 27.5 mmol) was added thereto, and the resultant mixture was stirred for 20 minutes, Subsequently, sodium triacetoxyborohydride (95%, 7.1 g, 31.8 mmol) and small amount of acetic acid were added thereto, and the mixture was stirred overnight at room temperature. A saturated aqueous sodium hydrogencarbonate solution was added thereto. The reaction mixture was extracted with chloroform, and the organic layer was washed with brine. The resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (chloroform/methanol = 30/1), whereby the target compound was obtained (6.7 g, 81%). ^-NMR (400MHz, CDC13) 5 1.07 (t, J = 7 Hz, 3H) , 1.24 (t, J = 7 Hz, 3H), 1.93-2.01 (m, 4H), 2.80 (t, J = 7 Hz, 2H), 3.77 (s, 2H), 4.00 (t, J = 6 Hz, 2H), 4.21 (q, J = 7 Hz, 2H), 4.55 (t, J = 6 Hz, 1H), 6.74-6.84 (m, 3H), 6.89-6.98 (m, 4H), 7.21 (t, J = 8 Hz, 1H) Production Example 3 Synthesis of Ethyl 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-fluorophenoxy)propyl]aminomethyl]phenoxy]butyrate fluorophenoxy)propyl]aminomethyl]phenoxy]butyrate (6.2 g, 15.9 mmol) was dissolved in N, Af-dimethylf ormamide (10 mL) , and N, A7-diisopropylethylamine (3.1 g, 23.8 mmol) was added dropwise thereto. Subsequently, 2-chlorobenzoxazole (2.9 g, 19.0 mmol) was added thereto, and the resultant mixture was stirred for 15 minutes at room temperature, followed by stirring overnight at 50°C. Subsequently, a saturated aqueous sodium hydrogencarbonate solution was added thereto. The reaction mixture was extracted with ethyl acetate, and the organic layer was washed with brine. The resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (n-hexane/ethyl acetate = 4/1), whereby the target compound was obtained (7.5 g, 93%). ^-NMR (400MHz, CDC13) 5 1.05 (t, J = 7 Hz, 3H) , 1.17 (t, J = 7 Hz, 3H), 1.96 (quintet, J = 7 Hz, 2H), 2.14 (quintet, J = 6 Hz, 2H), 3.70 (t, J = 7 Hz, 2H), 4.00 (t, J = 6 Hz, 2H), 4.12 (q, J = 7 Hz, 2H), 4.51 (t, J = 6 Hz, 1H), 4.72 (d, J = 16 Hz, 1H), 4.77 (d, J = 16 Hz, 1H), 6.75-6.81 (m, 3H), 6.86-7.00 (m, 4H), 7.01 (t, J = 8 Hz, 1H), 7.17 (t, J = 8 Hz, 1H), 7.19-7.23 (m, 2H), 7.36 (d, J = 7 Hz, 1H) Example 1 Synthesis of 2- [3- [ [N- (Benzoxazol-2-yl)-N-3-(4-fluorophenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) Ethyl 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-fluorophenoxy)propyl]aminomethyl]phenoxy]butyrate (7.3 g, 14.4 mmol) was dissolved in a methanol-tetrahydrofuran mixed solvent (25 mL), and an aqueous solution of 2 mol/L sodium hydroxide (21.6 mL, 43.2 mmol) was added dropwise thereto. The resultant mixture was stirred for 2 hours at 60°C and subjected to concentration under reduced pressure. A saturated aqueous sodium hydrogencarbonate solution was added thereto. Subsequently, the reaction mixture was extracted with ethyl acetate, and the organic layer was washed with brine. The resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (chloroform/methanol = 60/1), whereby the target compound was obtained (6.7 g, q.). ^-NMR (400MHz, CDC13) 5 1.04 (t, J = 7 Hz, 3H) , 1.95 (quintet, J = 7 Hz, 2H), 2.04 (quintet, J = 6 Hz, 2H), 3.56-3.64 (m, 2H), 3.87 (t, J = 6 Hz, 2H), 4.50 (t, J = 6 Hz, 1H), 4.62 (d, J = 16 Hz, 1H), 4.68 (d, J = 16 Hz, 1H) , 6.73-6.93 (m, 7H), 6.99 (t, J = 8 Hz, 1H), 7.10-7.20 (m, 3H), 7.34 (d, J = 8 Hz, 1H) In a manner similar to that described in Example 1, the compounds of Examples 2 through Example 30 were synthesized. Example 2 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) H-NMR (400MHz,CDC13) S:1.09(t, J = 7 Hz, 3H), 2.00(quintet, J = 7Hz, 2H), 3.79-3.81(m, 2H) , 4.13(t, J = 5 Hz, 2H ), 4.57(t, J = 7 Hz, 1H), 4.84(d, J = 6Hz, 2H), 6.73(d, J = 9Hz, 2H), 6.86(d, J= 8Hz, 1H), 6.87(s,lH), 6.92(d, J = 8 Hz, 1H), 7.02(t, J = 8 Hz, 1H ), 7.13-7.25(m, 5H), 7.36(d, J = 8Hz, 1H) . Example 3 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-2-(4- fluorophenoxy)ethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) (400MHz, DMSO-d6) 5 0.96 (t, J= 7 Hz, 3H) , 1.79-1.89 (m, 2H), 3.8 (t, J = 5 Hz, 2H), 4.21 (t, J= 5 Hz, 2H), 4.61 (t, J= 7Hz, 1H), 4.82 (s, 2H), 6.76 (d, J = 8 Hz, 1H), 6.89-6.93 (m, 4H), 7.02 (t, J= 8 Hz, 1H), 7.09 (t, J = 8Hz, 2H), 7.16 (d, J = 8 Hz, 1H), 7.24 (t, J = 8 Hz, 1H), 7.30 (d, J = 8 Hz, 1H), 7.40 (d, J= 8Hz, 1H) . Example 4 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-2-(4-methoxyphenoxy)ethyl]aminomethyl]phenoxy]butyric acid Example 5 Synthesis of 2-[3-[ [N-(Benzoxazol-2-yl)-N-3-(4- fluorophenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) 1H-NMR(400MHz, CDC13) 5 1.56 (s, 6H) , 2.04 (quintet, J = 7 Hz, 2H) , 3.59 (t, J = 7 Hz, 2H), 3.88 (t, J = 6 Hz, 2H) , 4.64 (s, 2H), 6.74-6.94 (m, 7H), 6.99 (t, J = 8 Hz, 1H), 7.11-7.19 (m, 3H), 7.36 (d, J = 7 Hz, 1H) Example 6 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminomethyl]phenoxy]-2-methylpropionic acid JH-NMR (400MHz,CDC13) 5 1.56(s, 6H), 3.81(t, J = 5 Hz, 2H), 4.13(t, J = 5 Hz, 2H ), 4.83(s, 2H), 6.74(d, J = 9Hz, 2H), 6.85(d, J = 8Hz, 1H), 6.89(s,lH), 6.96(d, J = 8 Hz, 1H), 7.02(t, J = 8 Hz, 1H ), 7.13-7.25(m, 5H) , 7.36(d, J = 7 Hz, 1H) . Example 7 Synthesis of 2-[4-[[N-(Benzoxazol-2-yl)-N-2-(3-dimethylaminophenoxy)ethyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) XH-NMR (400MHz, CDC13) 5 1.52 (s, 6H) , 2.87 (s, 6H) , 3.81 (t, J = 5 Hz, 2H), 4.09 (t, J = 5 Hz, 2H), 4.81 (s, 2H), 6.20 (s, 1H), 6.28 (d, J = 8 Hz, 1H) , 6.40 (d, 8 Hz, 1H) , 6.79 ( d, J = 8 Hz, 2H), 7.01 (t, J = 8 Hz, 1H), 7.08-7.18 (m, 4H), 7.23 (d, J = 8 Hz, 1H), 7.38 (d, J= 8Hz, 1H). Example 8 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3-(4-methanesulfonyloxyphenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) XH-NMR (400MHz, CDC13) 5 1.53 (s, 6H) , 2.12 (br s, 2H) , 3.09 (s, 3H), 3.74 (t, J = 1 Hz, 2H), 3.97 (t, J = 6 Hz, 2H), 4.74 (s, 2H), 6.80-6.91 (m, 5H), 7.11-7.26 (m, 6H), 7.44 (d, J = 7 Hz, 1H) Example 9 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH-NMR (400MHz, CDC13) 5 1.61 (d, J = 7 Hz, 3H) , 2.06 (quintet, J = 6 Hz, 2H), 3.61-3.65 (m, 2H), 3.92 (t, J = 6 Hz, 2H), 4.60-4.73 (m, 3H), 6.80-6.95 (m, 6H), 7.00 (t, J = 7 Hz, 1H), 7.10-7.26 (m, 5H), 7.36 (d, J = 7 Hz, 1H) Example 10 Synthesis of 2-[4-[ [N-(Benzoxazol-2-yl)-N-3-(4-methanesulfonyloxyphenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) (400MHz, CDC13) 5 1.58 (s, 6H) , 2.15 (br s, 2H) , 3.09 (s, 3H) , 3.80 (t, J = 7 Hz, 2H) , 4.00 (t, J = 6 Hz, 2H) , 4.79 (s, 2H), 6.83 (d, J = 9 Hz, 2H), 6.89 (d, J = 9 Hz, 2H), 7.16 (d, J = 9 Hz, 2H), 7.19 (d, J = 9 Hz, 2H) , 7.21-7.29 (m, 2H), 7.31 (t, J = 8 Hz, 1H), 7.54 (d, J = 8 Hz, 1H), 11.40 (br s, 1H) Sodium 2-[4-[[N-(benzoxazol-2-yl)-N-3-(4- methanesulfonyloxyphenoxy)propyl]aminomethyl]phenoxy]-2- methylpropionate (Figure Removed) 2-[4-[[N-(Benzoxazol-2-yl)-N-3-(4- methanesulfonyloxyphenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (5.96 g, 10.7 mmol) was dissolved in methanol. A solution of NaOMe (580 mg, 10.7 mmol) in methanol was added thereto at room temperature, and then the resultant mixture was stirred for 1 hour. Subsequently, the reaction mixture was subjected to concentration under reduced pressure, and n-hexane was added to the resultant concentrate, The thus-obtained solid was purified, whereby a white amorphous powder was obtained (5.2 g, 84%). XH-NMR (400MHz, CDC13) 5 1.61 (s, 6H) , 2.03 (br s, 2H) , 3.08 (s, 3H), 3.56 (br s 2H), 3.88 (br s, 2H), 4.64 (s, 2H), 6.81- 6.83 (m, 4H), 7.01 (t, J = 7 Hz, 1H), 7.08 (d, J = 8 Hz, 2H), 7.14-1.18 (m, 4H), 7.46 (d, J = 8 Hz, 1H) Example 11 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 460 (M+) Sodium 2- [3-[[N-(benzoxazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxy]-2-methylpropionate XH-NMR (400MHz, CDC13) 5 1.36 (s, 6H), 2.80 (quintet, J =7Hz, 2H), 3.64 (t, J =7Hz, 2H), 3.94 (t, J=6Hz, 2H), 4.62 (s, 2H), 6.73 (d, J =8Hz, 1H), 6.82-6.86 (m, 4H), 6.89-6.96 (m, 2H), 7.04-7.15 (m, 3H), 7.21-7.26 (m, 2H), 7.30 (d, J=8Hz, 1H) . Example 12 Synthesis of 3-[ [N-(Benzoxazol-2-yl)-N-3-phenoxypropyl]aminomethyl]phenoxyacetic acid (Figure Removed) Sodium 3-[[N-(benzoxazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxyacetate (400MHz, CD3OD) 5 2.09 (quintet, J=7Hz, 2H), 3.69 (t, J=7Hz, 2H), 3.97 (t, J=6Hz, 2H), 4.52 (s, 2H), 4.74 (s, 2H), 6.83-6.91 (m, 6H) , 6.99 (td, J=8, IHz, 1H) , 7.13 (td, J=8, IHz, 1H), 7.18-7.27 (m, 5H). Example 13 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3-phenoxypropyl]aminomethyl]phenoxy]butyric acid (Figure Removed) MS(m/z) 460 (M+) Sodium 2- [3-[[N- (benzoxazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxy]butyrate(Figure Removed) XH-NMR (400MHz, DMSO-d6) 5 0.90 (t, J=7Hz, 3H), 1.67-1.75 (m, 2H), 2.09-2.11 (m, 2H), 3.67 (t, J=7Hz, 2H), 3.99-4.03 (m, 3H), 4.69 (s, 2H), 6.65-6.75 (m, 3H), 6.90-7.00 (m, 4H), 7.13 (t, J =8Hz, 2H), 7.24-7.29 (m, 3H), 7.33 (d, J =7Hz, 1H) . Example 14 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid MS(m/z) 490 (M+)Sodium 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]butyrate (Figure Removed) (400MHz, CD3OD) 5 1.03 (t, J=7Hz, 3H) , 1.87-1.92 (m, 2H), 2.09 (quintet, J=6.6Hz, 2H), 3.67-3.73 (m, 5H), 3.95 (t, J =6Hz, 2H), 4.35 (t, J =6Hz, 1H), 4.74 (s, 2H), 6.78-6.90 (m, 7H) , 7.00 (td, J =8, IHz, 1H), 7.14-7.27 (m, 4H) . Example 15 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 490 (M+) Sodium 2- [3- [ [N- (benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionate (Figure Removed) XH-NMR (400MHz, CDC13) 5 1.35 (s, 6H) , 2.03 (quintet, J =7Hz, 2H), 3.60 (t, J =7Hz, 2H), 3.70 (s, 3H), 3.87 (t, J =6Hz, 2H), 4.59 (s, 2H), 6.70-6.83 (m, 6H), 6.93 (t, J=8Hz, 1H), 7.00-7.02 (m, 2H), 7.08 (t, J =8Hz, 1H) , 7.13 (d, J =8Hz, 1H), 7.29 (d, J =8Hz, 1H). Example 16 Synthesis of 2-[3- [ [N-(Benzoxazol-2-yl)-N-3-(4-chlorophenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 494 (M+), 496(M++2) Sodium 2-[3-[[N- (benzoxazol-2-yl)-N-3-(4- chlorophenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionate (Figure Removed) (400MHz, DMSO-d6) 6 1.35 (s, 6H) , 2.08 (quintet, J =7Hz, 2H), 3.64 (t, J =7Hz, 2H), 4.01 (t, J =6Hz, 2H), 4.66 (s, 2H), 6.71 (d, J =8Hz, 1H), 6.72-6.76 (m, 2H), 6.94-7.00 (m, 3H), 7.08 (t, J =8Hz, 1H) , 7.13 (t, J =8Hz, 1H), 7.26-7.35 (m, 4H). Example 17 Synthesis of 2-[4-[[N-(Benzoxazol-2-yl)-N-3-(3-dimethylaminophenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid Sodium 2-[4-[[N-(benzoxazol-2-yl)-N-3-(3- dimethylaminophenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionate (Figure Removed) (400MHz, CD3OD) 5 1.52 (s, 6H) , 2.05-2.08(m, 2H) , 2.87 (s, 6H), 3.86 (t, J=5Hz, 2H), 4.18 (t, J=5Hz, 2H) , 4.80 (s, 2H) , 6.30-6.47 (m, 3H), 6.84 (dd, J=7, 2Hz, 2H), 7.03-7.09 (m, 2H), 7.15-7.31 (m, 5H). Example 18 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-2-phenoxyethyl]aminomethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 432 (M+) Sodium 2- [3-[[N- (benzoxazol-2-yl)-N-2-phenoxyethyl]aminomethyl]phenoxy]propionate (Figure Removed) 400MHz, DMSO-d6) 5 1.46(d, J=7Hz, 3H) , 3.87 (t. J=6Hz, 2H), 4.23 (t, J=6Hz, 2H), 4.75-4.80 (m, 3H), 6.76 (dd, J=8, 2Hz, 1H), 6.88-6.93 (m, 4H), 7.02 (t, J=8Hz, 1H), 7.16 (t, J=8Hz, 1H), 7.24 (t, J=8Hz, 1H), 7.28-7.32 (m, 4H), 7.40 (d, J=8Hz, 1H). Exsample 19 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3-(3-dimethylaminophenoxy)propyl]aminomethyl]phenoxy]propionic MS(m/z) 489 (M+) Sodium 2-[3-[[N-(benzoxazol-2-yl)-N-3-(3- dimethylaminophenoxy)propyl]aminomethyl]phenoxy]propionate (Figure Removed) (400MHz, CDC13) 5 1.38 (d, J=7Hz, 3H) , 2.04-2.08 (m, 2H), 2.86 (s, 6H), 3.60-3.65 (m, 2H) , 3.93 (t, J =6Hz, 2H) , 4.51-4.55 (m, 1H), 4.57 (d, J =16Hz, 1H) , 4.66 (d, J =16Hz, 1H), 6.25-6.28 (m, 2H) , 6.36 (dd, J =11, 2Hz, 1H), 6.70(d, J = 8Hz, 1H), 6.77(d, J =8Hz, 2H) , 6.94 (t, J =8Hz, 1H), 7.02- 7.11 (m, 3H), 7.15 (d, J =8Hz, 1H), 7.31 (d, J =8Hz, 1H). Exsample 20 2- [3-[[N-(Benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 476 (M+) Sodium 2-[3-[[N-(benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionate (Figure Removed) (400MHz, CD3OD) 5 1.50 (d, J =7Hz, 3H) , 2.09 (quintet, J =7Hz, 2H), 3.68-3.75 (m, 5H) , 3.94 (t, J=6Hz, 2H) , 4.58 (q, J =7Hz, 1H) , 4.74 (s, 2H) , 6.78-6.87(m, 7H) , 7.00(td, J =8, IHz, 1H) , 7.12-7.27 (m, 4H) . Example 21 Synthesis of 2- [3- [ [N- (Benzoxazol-2-yl) -N-2- phenoxyethyl] aminomethyl] phenoxy] -2-methylpropionic (Figure Removed) (m/z) 446(M+) Example 22 Synthesis of 2-[4-[[N-(Benzoxazol-2-yl)-N-2- phenoxyethyl]aminomethyl]phenoxy]-2-methylpropionic acid (m/z) 446(M+) Example 23 Synthesis of 2- [2-[[N-(Benzoxazol-2-yl)-N-2- phenoxyethyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) Example 24 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-2- phenoxyethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) MS(m/z) 446(M+) Example 25 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-2-(3-dimethylaminophenoxy)ethyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed Example 26 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3-(3- dimethylaminophenoxy)propyl]aminomethyl]phenoxy]-2- methylpropionic acid (Figure Removed) MS(m/z) 503 (M+) Example 27 Synthesis of 2-[4-[[N-(Benzoxazol-2-yl)-N-2-(4- methoxyphenoxy)ethyl]aminomethyl]phenoxy]-2-methylpropionic acid MS(m/z) 476(M+) Example 28 Synthesis of 2-[4-[[N-(Benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) Example 29 Synthesis of 2- [ 4-[[N-(Benzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) Synthesis of 2-[4-[[N-(Benzoxazol-2-yl)-N-3-(4-chlorophenoxy)propyl]aminomethyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 494 (M+) , 496(M++2) Production Example 4 N-2-Phenoxyethyl-3-hydroxyphenylacetamide (Figure Removed) 3-Hydroxyphenylacetate (1.5 g, 9.88 mmol) was dissolved in dichloromethane. WSC-HC1 (2.82 g, 14.76 mmol) and 2-phenoxyethylamine (1.5 g, 10.95 mmol) were added thereto, and then the resultant mixture was stirred for 4 hours at room temperature. After completion of reaction, water was added to the reaction mixture. The resultant mixture was extracted with chloroform, followed by washing with brine. The resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by chromatography, whereby 2.85 g, a stoichiometric amount, of the target compound was obtained as a pale yellow oil. 'H-NMR (400MHz, CDC13) 5 3.38 (s, 2H), 3.61(q, J=5Hz, 2H) , 4.00(t, J=5Hz, 2H), 5.97(br, 1H), 6.71-6.86 (m, 4H), 6.96(t, J=8Hz, 1H), 7.07-7.30(m, 4H). Production Example 5 Synthesis of tert-Butyl 2-[3-(N-2- phenoxyethylaminocarbonylmethyl)phenoxy]propionate (Figure Removed) A7-2-Phenoxyethyl-3-hydroxyphenylacetoamide (1.4 g, 5.16 mmol) was dissolved in acetonitrile (10 mL). tert-Butyl 2-bromopropionate (1.3 g, 6.19 mmol) and potassium carbonate (1.07 g, 7.74 mmol) were added thereto, and then the resultant mixture was stirred overnight at 80°C. After completion of reaction, the reaction mixture was subjected to concentration under reduced pressure. Ethyl acetate was added thereto. The mixture was washed with water and brine and dried over anhydrous sodium sulfate. The dried mixture was subjected to concentration under reduced pressure and purification by chromatography, whereby 1.14 g of the target compound was obtained as a pale yellow oil (yield 54%). Production Example 6 Synthesis of tert-Butyl 2-[3-[2-(N-2-phenoxyethyl)aminoethyl]phenoxy]propionate tert-Butyl 2-[3-(2- phenoxyehtylaminocarbonylmethyl)phenoxy]propionate (1.14 g, 2.86 mmol) was dissolved in tetrahydrofuran (5 mL) under argon atmosphere. The mixture was cooled to 0°C, and then a 1M borane-THF complex in THF solution (8.5 mL, 8.5 mmol) was added thereto. The resultant mixture was stirred for 30 minutes, followed by stirring for 3 hours at 50°C. After completion of reaction, the reaction mixture was allowed to cool. Subsequently, methanol was added thereto and subjected to concentration under reduced pressure. Subsequently, chloroform was added to the concentrate. The mixture was washed with water and brine and dried over anhydrous sodium sulfate. The dried mixture was subjected to concentration under reduced pressure and purification by chromatography, whereby 940 mg of the target compound was obtained as a colorless oil (yield 85%). ^-NMR (400MHz, CDC13) 5 1.43 (s, 9H, ) 1.56(d, J=7Hz, 3H) , 2.79(t, J=7Hz, 2H), 2.93(t, J=7Hz, 2H), 3.01(t, J=5Hz, 2H), 4.05(t, J=5Hz, 2H), 4.60(q, J=7Hz, 1H), 6.69(dd,J=2, 8Hz, 1H), 6.75(s, 1H), 6.82(d, J=8Hz, 1H), 6.86-6.97(m, 3H), 7.18(t, J=8Hz, 1H), 7.25-7.29(m, 2H). Production Example 7 Synthesis of tert-Butyl 2-[3-[2-[N-(benzoxazol-2-yl)-N-2- (Figure Removed) tert-Butyl 2-[3-[2-(N-2- phenoxyehtyl)aminoethyl]phenoxy]propionate (200 mg, 0.519 mmol) was dissolved in N, A7-dimethylf ormamide. Subsequently, 2-chlorobenzoxazole (95 mg, 0.623 mmol) and diisopropylethylamine (0.1 mL, 0.623 mmol) were added thereto, and the mixture was stirred overnight at 80°C. After completion of reaction, ethyl acetate was added. Washing was performed with water and brine, followed by drying over magnesium sulfate. The reaction mixture was subjected to concentration under reduced pressure, and purification by chromatography, whereby 266 mg, a stoichiometric amount, of the target compound was obtained as a yellow oil. ^-NMR (400MHz, CDC13) 5 1.43 (s, 9H) 1.57(d, J=8Hz, 3H) , 3.02(t, J=8Hz, 2H), 3.82-3.90(m, 4H), 4.20(t, J=5Hz, 2H), 4.60(q, J=7Hz, 1H), 6.69(dd, J=2, 8Hz, 1H), 6.72-7.02(m, 6H), 7.18(t, J=8Hz, 1H), 7.14-7.29(m, 4H), 7.36(d, J=8Hz, 1H). Example 31 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-2-phenoxyethyl]aminoethyl]phenoxy]propionic acid (Figure Removed) tert-Butyl 2-[3-[2-[N-(benzoxazol-2-yl)-N-2-phenoxyehtyl]aminoethyl]phenoxy]propionate (266 mg, 0.530 mmol) was dissolved in dichloromethane (3 mL). Subsequently, trifluoroacetic acid (1 mL) was added thereto, and the mixture was stirred for 1 hour at room temperature. After completion of reaction, the reaction mixture was subjected to concentration under reduced pressure, and the residue was subjected to purification by preparative TLC, whereby 115 mg of the target compound was obtained as a yellow oil (yield 54%) . XH-NMR (400MHz, CDC13) 5 1.60(d, J=7Hz, 3H) , 3.02(t, J=6Hz, 2H), 3.68-4.19(m, 6H) , 4.60(q, J=7Hz, 1H), 6.58(s, 1H) , 6.79(d, J=8Hz, 1H) , 6.85(d, J=8Hz, 2H) , 6.90-6.97(m, 2H), 7.12(t, J=8Hz, 1H), 7.20-7.28(m, 5H), 7.44(d, J=8Hz, 1H) In a manner similar to that described in Example 31, the compounds of Examples 32 through Example 73 were synthesized. Example 32 Synthesis of 2-[3-[3-[N-(Benzoxazol-2-yl)-N-2-phenoxyethyl]aminopropyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 474 (M+) Example 33 Synthesis of 2- [4-[3-[N-(Benzoxazol-2-yl)-N-2- phenoxyethyl]aminopropyl]phenoxy]-2-methylpropionic acid S(m/z) 474 (M+) Example 34 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-2-(4- fluorophenoxy)ethyl]aminoethyl]phenoxy]propionic acid MS(m/z) 464 (M+) Example 35 Synthesis of 2-[3-[2-[N-(5-Fluorobenzoxazol-2-yl)-N-2-(4-fluorophenoxy)ethyl]aminoethyl]phenoxy]propionic acid (400MHz, CDC13) 5 1.57(d, J=7Hz, 3H) , 2.90(t, J=7Hz, 2H), 3.64-3.80(m, 6H), 4.65(q, J=7Hz, 1H), 6. 67-7.12(m, 11H) Example 36 Synthesis of 2-[3-[2-[N-(5-Chlorobenzoxazol-2-yl)-N-2-(4-fluorophenoxy)ethyl]aminoethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 498 (M+), 500(M++2) Example 37 Synthesis of 2-[3-[2-[N-2-(4-Fluorphenoxy)ethyl-N-(5- methoxybenzoxazol-2-yl)]aminoethyl]phenoxy]propionic acidO XH-NMR (400MHz, CDC13) 5 1.50(d, J=7Hz, 3H) , 2.84(t, J=7Hz, 2H), 3.53-3.95(m, 9H), 4.61(q, J=7Hz, 1H), 6.51(dd, J=3, 9Hz, 1H), 6.63-6.92(m, 7H), 7.02-7.30(m, 3H) Example 38 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-3- phenoxypropyl]aminoethyl]phenoxy]butyric acid (Figure Removed) XH-NMR (400MHz, CDC13) 5 1.07(t, J=7Hz, 3H) , 1. 98-2.06 (m, 4H) , 2.87(t, J=7Hz, 2H) , 3.45-3.74 (4H, m) , 3.92(t, J=6Hz, 2H) , 4.55(t, J=6Hz, 1H) , 6.76-6.80(m, 2H) , 6.85(d, J=8Hz, 2H), 6.91-7.03(m, 3H), 7.09-7.19(m, 4H), 7.25(t, J = 8 Hz, 1H), 7.33(d, J=8Hz, 1H). Example 39 Synthesis of 2-[3-[2-[N-(5-Fluorobenzoxazol-2-yl)-N-3-phenoxypropyl]aminoethyl]phenoxy]butyric acid (Figure Removed) XH-NMR (400MHz, CDC13) 6 1.07(t, J=8 Hz, 3H) , 1. 98-2.06 (m, 4H), 2.91(t, J=7Hz, 2H), 3.49-3.74(m, 4H) , 3.95(t, J=6Hz, 2H) , 4.56(q, J=6Hz, 1H) , 6.65-7.26(m, 11H), 8.06(d, J=7Hz, 1H) Example 40 Synthesis of 2-[3- [2-[N-(5-Chlorobenzoxazol-2-yl)-N-3- phenoxypropyl]aminoethyl]phenoxy]butyric acid MS(m/z) 508 (M+), 510(M++2) Example 41 Synthesis of 2- [3-[2- [N-(Benzoxazol-2-yl)-N-2- phenoxyethyl]aminoethyl]phenoxy]butyric acid XH-NMR (400MHz, CDC13) 5 1.08(t, J=7Hz, 3H), 1.96-2.02(m, 2H), 2.95(t, J=7Hz, 2H) , 3.58-3.64 (m, 1H) , 3.77-4. 14 (m, 5H) , 4.52(q, J=6Hz, 1H) , 6.71(s, 1H) , 6.79-6.82(m, 2H) , 6.85(d, J=7Hz, 1H), 6.92(t, J=7Hz, 1H) , 7.04(t, J=8Hz, 1H) , 7.16-7.26(m, 6H), 7.37(d, J=8Hz, 1H) Example 42 Synthesis of 2-[ 3-[2-[N-(5-Methoxybenzoxazol-2-yl)-N-2-phenoxyethyl]aminoethyl]phenoxy]butyric acid (Figure Removed) Example 43 Synthesis of 2-[3-[2-[N-(5-Fluorobenzoxazol-2-yl)-N-2- phenoxyethyl]aminoethyl]phenoxy]propionic acid XH-NMR (400MHz, CDC13) 5 1.60(d, J=7Hz, 3H) , 3.00(t, J=7Hz, 2H), 3.70-4.18(m, 6H), 4.67(q, J=7Hz, 1H), 6.62(s, 1H), 6.72- 6.81(m, 2H), 6.85(d, J=8Hz, 2H), 6.90(d, J=8Hz, 1H), 6.95(t, J=7Hz, 1H), 7.10-7.30(m, 5H) Example 44 Synthesis of 2-[3-[2-[N-(5-Methoxybenzoxazol-2-yl)-N-2- phenoxyethyl]aminoethyl]phenoxy]propionic acid O (Figure Removed) XH-NMR (400MHz, CDC13) 5 1.59(d, J=7Hz, 3H) , 3.00(t, J=6Hz, 2H), 3.62-3.70(m, 1H), 3.80(s, 3H), 3.90-4.21(m, 5H), 4.58(q, J=7Hz, 1H), 6.49(s, 1H), 6.72(dd, J=2, 9Hz, 1H), 6.79-6.98(m, 6H), 7.09(d, J=9Hz, 2H), 7.21-7.30(m, 2H) Example 45 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-2-(4- methoxyphenoxy)ethyl]aminoethyl]phenoxy]butyric acid MS(m/z) 490 (M+) Example 46 Synthesis of 2- [ 3- [2-[N-(5-Fluorobenzoxazol-2-yl)-N-2-(4 methoxyphenoxy)ethyl]aminoethyl]phenoxy]butyric acid F MS(m/z) 508 (M+) Example 47 Synthesis of 2-[3-[2-[N-(5-Chlorobenzoxazol-2-yl)-N-2-(4- methoxyphenoxy)ethyl]aminoethyl]phenoxy]butyric acid Example 48 Synthesis of 2-[3-[2-[N-(5-Methoxybenzoxazol-2-yl)-N-2- (4- methoxyphenoxy)ethyl]aminoethyl]phenoxy]butyric acid MS(m/z) 520 (M+) Example 49 Synthesis of 2- [3- [2- [N-(5-Fluorobenzoxazol-2-yl) -N-3-(4- methoxyphenoxy)propyl]aminoethyl]phenoxy]butyric acid (Figure Removed) (400MHz, CDC13) 6 1.07(t, J=8Hz, 3H) , 1.94-2.06(m, 4H), 2.88-2.95(m, 2H), 3.49-3.74(m, 7H), 3.91(t, J=6Hz, 2H), 4.56(q, J=6Hz, 1H), 6.74-7.26(m, 11H) Example 50 Sythesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-3-(4-fluorophenoxy)propyl]aminoethyl]phenoxy]butyric acid Example 51 Synthesis of 2-[3-[2-[N-3-(4-Fluorophenoxy)propyl- N-(5- methoxybenzoxazol-2-yl)]aminoethyl]phenoxy]butyric acid (Figure Removed) Example 52 Synthesis of 2-[3-[2-[N-3-(4-Chlorophenoxy)propyl- N-(5- methoxybenzoxazol-2-yl)]aminoethyl]phenoxy]butyric acid (Figure Removed) MS(m/z) 538 (M+) , 540(M++2) Example 53 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-3-(4- chlorophenoxy)propyl]aminoethyl]phenoxy]butyric acid (Figure Removed) MS(m/z) 508 (M+), 510(M++2) Example 54 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminoethyl]phenoxy]butyric acid (Figure Removed) XH-NMR (400MHz, CD3OD) 5 0.94(t, J=7Hz, 3H) , 1.77-1.85(m, 2H) , 2.88(t, J=7Hz, 2H), 3.71(t, J=5Hz, 2H), 3.74(t, J=7Hz, 2H) , 4.03(t, J=5Hz, 2H) , 4.45(t, J=5Hz, 1H) , 6.61-7.19(m, 12H) . Example 55 Synthesis of 2- [3-[2-[N-(5-Chlorobenzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminoethyl]phenoxy]butyric acid (Figure Removed) XH-NMR (400MHz, CD3OD) 5 0.94(t, J=7Hz, 3H) , 1.77-1.87 (m, 2H), 2.89(t, J=7Hz, 2H) , 3.71-3.77(m, 4H) , 4.04(t, J=5Hz, 2H), 4.44(t, J=6Hz, 1H), 6.61-7.14(m, 11H). Example 56 Synthesis of 2-[3-[2-[N-2-(4-Chlorophenoxy)ethyl-N-(5- methoxybenzoxazol-2-yl)]aminoethyl]phenoxy]butyric acid (Figure Removed) xH-NMR (400MHz, CD3OD) 5 0.94(t, J=7Hz, 3H) , 1.77-1.85(m, 2H), 2.88(t, J=7Hz, 2H), 3.68(s, 3H), 3.70-3.74(m, 4H), 4.02(t, J=5Hz, 2H), 4.45(t, J=6Hz, 1H), 6.48-7.12(m, 11H). Example 57 Synthesis of 2-[3-[2- [N-(Benzothiazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminoethyl]phenoxy]butyric acid (Figure Removed) (400MHz, CD3OD) 5 1.04(t, J=7Hz, 3H) , 1. 88-1. 93 (m, 2H), 3.00(t, J=7Hz, 2H), 3.80(t, J=7Hz, 2H), 3.84(t, J=5Hz, 2H), 4.15(t, J=5Hz, 2H), 4.53(t, J=5Hz, 1H) , 6.74-7.63(m, 12H) .mple 58 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-2-(4- methoxyphenoxy)ethyl]aminoethyl]phenoxy]propionic acid (Figure Removed) Example 59 Synthesis of 2-[3-[2-[N-(5-Fluorobenzoxazol-2-yl)-N-2-(4- methoxyphenoxy)ethyl]aminoethyl]phenoxy]propionic acid O (Figure Removed) MS(m/z) 494 (M+) Example 60 Synthesis of 2-[3-[2-[N-(5-Chlorobenzoxazol-2-yl)-N-2-(4-methoxyphenoxy)ethyl]aminoethyl]phenoxy]propionic acid Cl (Figure Removed) MS(m/z) 510 (M+), 512(M++2) Example 61 Synthesis of 2- [3-[2-[N-(5-Methoxybenzoxazol-2-yl)-N-2-(4- methoxyphenoxy)ethyl]aminoethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 506 (M+) Example 62 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-3- phenoxypropyl]aminoethyl]phenoxy]propionic acidMS(m/z) 460 (M+) Example 63 Synthesis of 2-[3-[2-[N-(5-Fluorobenzoxazol-2-yl)-N-3- phenoxypropyl]aminoethyl]phenoxy]propionic acid MS(m/z) 478 (M+) Example 64 Synthesis of 2-[3-[2-[N-(5-Chlorobenzoxazol-2-yl)-N-3- phenoxypropyl]aminoethyl]phenoxy]propionic acid (Figure Removed) S(m/z) 494 (M+) , 496(M++2) Example 65 Synthesis of 2-[3-[2-[N-(5-Methoxybenzoxazol-2-yl)-N-3- phenoxypropyl]aminoethyl]phenoxy]propionic acid (Figure Removed) Example 66 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-3-(4- chlorophenoxy)propyl]aminoethyl]phenoxy]propionic acid (Figure Removed) (m/s)94 (M+), 496(M++2) Example 67 Synthesis of 2-[3-[2-[N-3-(4-Chlorophenoxy)propyl-N-(5- fluorobenzoxazol-2-yl)]aminoethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 512 (M+), 514(M++2) Example 68 Synthesis of 2-[3-[2-[N-(5-Chlorobenzoxazol-2-yl)-N-3-(4- chlorophenoxy)propyl]aminoethyl]phenoxy]propionic acid MS (m/z) 528 (M+) ,530 (M++2) ,532 (M++4) Example 69 Synthesis of 2-[3-[2-[N-3-(4-Chlorophenoxy)propyl-N-(5-methoxybenzoxazol-2-yl)]aminoethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 524 (M+), 526(M++2) Example 70 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-3-(4- fluorophenoxy)propyl]aminoethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 478 (M+) Example 71 Synthesis of 2-[3-[2-[N-(5-Fluorobenzoxazol-2-yl)-N-3-(4- fluorophenoxy)propyl]aminoethyl]phenoxy]propionic acid MS(m/z) 496(M+)Example 72 Synthesis of 2-[3-[2-[N-(5-Chlorobenzoxazol-2-yl)-N-3-(4- fluorophenoxy)propyl]aminoethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 512 (M+) ,514 (M++2) Example 73 Synthesis of 2-[3-[2-[N-3-(4-Fluorophenoxy)propyl-N-(5- methoxybenzoxazol-2-yl)]aminoethyl]phenoxy]propionic acid (Figure Removed) MS(m/z) 508 (M+) Production Example 8 Synthesis of N-(4-Chlorophenoxyethyl)-3-(2- methoxyphenyl)propanamide 3-(2-Methoxyphenyl)propionic acid (8.3 g, 46.2 mmol) was dissolved in tetrahydrofuran (20 mL), and 4-chlorophenoxyethylamine (10.3 g, 60.0 mmol) was added dropwise thereto at room temperature. Subsequently, a solution (10 mL) of WSC • HC1 (11.5 g, 60.0 mmol) in methylene chloride was slowly added dropwise thereto under ice-cooling, followed by stirring overnight. Under ice cooling, diluted hydrochloric acid was added dropwise thereto, followed by extraction with chloroform. The organic layer was washed with brine, and the resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (chloroform/methanol = 20/1), whereby the target compound was obtained (12.8 g, 83%). 1H-NMR(400MHz, CDC13) 5 2.50 (t, J = 8 Hz, 2H) , 2.95 (t, J = 8 Hz, 2H), 3.59-3.63 (m, 2H), 3.81 (s, 3H), 3.91 (t, J = 5 Hz, 2H), 5.87 (br s, 1H), 6.75-6.84 (m, 4H), 7.12 (d, J = 7 Hz, 2H) , 7.23 (d, J = 9 Hz, 2H) Production Example 9 N- (4-Chlorophenoxyethyl)-3-(2-methoxyphenyl)propanamide 99 Synthesis of N-(4-Chlorophenoxyethyl)-3-(2-hydroxyphenyl)propanamide (12.8 g, 38.3 mmol) was dissolved in methylene chloride (10.0 mL) . Subsequently, a 1.OM-boron tribromide/methylene chloride solution (49.8 mL, 49.8 mmol) was slowly added dropwise thereto under ice-cooling, followed by stirring for 1 hour at room temperature. Subsequently, water was slowly added dropwise thereto under ice-cooling, followed by stirring for 30 minutes. The resultant mixture was extracted with chloroform. The organic layer was washed with brine, and the resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by column chromatography (n-hexane/ethyl acetate = 20/1), whereby a white solid was obtained (11.6 g, 95%). 1H-NMR(400MHz, CDC13) 5 2.64 (t, J = 6 Hz, 2H) , 2.92 (t, J = 6 Hz, 2H,), 3.61-3.65 (m, 2H), 3.94 (t, J = 5 Hz, 2H) , 5.99 (br s, 1H) , 6.75 (d, J = 9 Hz, 2H) , 6.82 (t, J = 7 Hz, 1H) , 6.88 (d, J = 7 Hz, 1H), 7.04 (d, J = 7 Hz, 1H), 7.07 (t, J = 7 Hz, 1H), 7.21 (d, J = 9 Hz, 2H), 8.66 (s, 1H) Production Example 10 Synthesis of tert-Butyl 2-[2-[2-[N-2-(4-chlorophenoxy)ethylaminocarbonyl]ethyl]phenoxy]-2-methylpropionate N- (4-Chlorophenoxyethyl)-3-(2-hydroxyphenyl)propanamide (11.6 g, 36.3 mmol) was dissolved in acetonitrile (15 mL), and potassium carbonate (15.0 g, 109 mmol) was added thereto. Subsequently, tert-butyl 2-bromoisobutyrate (20.2 g, 90.7 mmol) was added thereto, followed by stirring for 4 days at 70°C. Subsequently, water was added thereto, and the resultant mixture was extracted with ethyl acetate. The organic layer was washed with brine, and the resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (chloroform/methanol = 50/1), whereby the target compound was obtained (7.4 g, 44%). Production Example 11 Synthesis of tert-Butyl 2- [2-[3-[N-2-(4- chlorophenoxy)ethyl]aminopropyl]phenoxy]-2-methylpropionate (Figure Removed) tert-Butyl 2-[2-[2-[2-(4- chlorophenoxy)ethylaminocarbonyl]ethyl]phenoxy]-2-methylpropionate (7.4 g, 16.0 mmol) was dissolved in tetrahydrofuran (5.0 mL). Subsequently, a 1.OM borane-tetrahydrofuran complex in tetrahydrofuran solution (32.0 mL, 32.0 mmol) was added dropwise at room temperature, and the mixture was stirred for three hours at 50°C. Concentrated hydrochloric acid was added under ice-cooling, and the mixture was stirred for three hours at room temperature. Aqueous 80% ethylamine solution was added dropwise under ice-cooling, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, followed by drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (chloroform/methanol = 50/1), whereby the target compound was obtained (3.9 g, 54%). 1H-NMR(400MHz, CDC13) 5 1.40 (s, 9H) , 1.58 (s, 6H) , 1.83 (quintet, J = 7 Hz, 2H), 2.67 (t, J = 8 Hz, 2H), 2.70 (t, J = 7 Hz, 2H), 2.99 (t, J = 5 Hz, 2H), 4.03 (t, J = 5 Hz, 2H), 6.68 (d, J = 8 Hz, 1H), 6.82 (t, J = 9 Hz, 2H), 6.84-6.88 (m, 1H), 7.05 (t, J = 8 Hz, 1H), 7.12 (d, J = 8 Hz, 1H) , 7.22 (d, J = 9 Hz, 2H) Production Example 12 Synthesis of tert-Butyl 2-[2-[3-[N-(benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminopropyl]phenoxy]-2-methylpropionate (Figure Removed) tert-Butyl 2-[2-[3-[N-2-(4- chlorophenoxy)ethyl]aminopropyl]phenoxy]-2-methylpropionate (3.9 g, 8.71 mmol) was dissolved in DMF (5.0 mL), and diisopropylethylamine (1.4 g, 10.5 mmol) was added dropwise thereto. Subsequently, 2-chlorobenzoxazole (1.6 g, 10.5 mmol) was added dropwise thereto, and the mixture was stirred overnight at 70°C. Subsequently, water was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, followed by drying over anhydrous sodium sulfate. The dried mixture was subjected to concentration under reduced pressure, and purification by silica gel chromatography (n-hexane/ethyl acetate = 4/1), whereby the target compound was obtained (4.5 g, 90%). 1H-NMR(400MHz/ CDC13) 5 1.37 (s , 9H) , 1.57 (s, 6H) , 2.02-2.10 (m, 2H), 2.71 (t, J = 8 Hz, 2H), 3.70 (t, J = 8 Hz, 2H), 3.93 (t, J = 6 Hz, 2H), 4.22 (t, J = 5 Hz, 2H), 6.68 (d, J = 8 Hz, 1H) , 6.78 (t, J= 9 Hz, 2H) , 6.87 (t, J = 8 Hz, 1H) , 7.00 (t, J = 8 Hz, 1H), 7.04-7.22 (m, 3H), 7.20 (d, J = 9 Hz, 2H), 7.23 (d, J = 8 Hz, 1H), 7.35 (d, J = 8 Hz, 1H) Example 74 Synthesis of 2-[2-[3-[N-(Benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminopropyl]phenoxy]-2-methylpropionic acid (Figure Removed) tert-Butyl 2-[2-[3-[N-(benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminopropyl]phenoxy]-2-methylpropionate (4.5 g, 7.87 mmol) was dissolved in methylene chloride (10.0 mL) . Subsequently, 50%-trifluoroacetic acid/methylene chloride solution (6.8 g) was added dropwise thereto, and the mixture was stirred for three hours at room temperature. The resultant mixture was subjected to concentration under reduced pressure, toluene azeotrope, and purification by silica gel chromatography (chloroform/methanol = 50/1), whereby the target compound was obtained (3.3 g, 83%). 1H-NMR(400MHz, CDC13) 5 1.61 (s, 6H) , 1.94-2.14 (br, 2H) , 2.69 (t, J = 8 Hz, 2H), 3.64 (t, J = 8 Hz, 2H), 3.85 (t, J = 5 Hz, 2H), 4.09 (t, 5 Hz, 2H) , 6.70 (d, J = 9 Hz, 2H) , 6.81 (d, J = 8 Hz, 1H), 6.89 (t, J = 7 Hz, 1H), 7.00 (t, J = 7 Hz, 1H), 7.10-7.19 (m, 3H) , 7.16 (d, J = 9 Hz, 2H), 7.21 (d, J = 8 Hz, 1H), 7.35 (d, J = 8 Hz, 1H) Sodium 2-[2-[3-[N-(benzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminopropyl]phenoxy]-2-methylpropionate (Figure Removed) 2-[2-[3-[N-(Benzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminopropyl]phenoxy]-2-methylpropionic acid (3.2 g, 6.28 mmol) was dissolved in methanol. A solution of NaOMe (340 mg, 6.28 mmol) in methanol was added thereto at room temperature, and then the resultant mixture was stirred for 1 hour. Subsequently, the reaction mixture was subjected to concentration under reduced pressure, and n-hexane was added to the resultant concentrate. The thus-obtained solid was purified, whereby a white amorphous powder was obtained (2.7 g, 81%). 1H-NMR( 400MHz, CDC13) 5 1.35 (s, 6H) , 1.80-2.00 (br, 2H) , 2.48-2.60 (br, 2H) , 3.45-3.60 (br, 2H) , 3.80 (br s, 2H) , 4.05-4.13 (br, 2H) , 6.70 (d, J = 9 Hz, 2H) , 6.75-6.80 (m, 2H), 6.87-7.01 (m, 3H), 7.08 (t, J = 8 Hz, 1H), 7.13-7.18 (m, 1H), 7.14 (d, J = 9 Hz, 2H), 7.28 (t, J = 8 Hz, 1H) MS(FAB) m/z : 533 [ (M++l)+2], 531(M++1) In a manner similar to that described in Example 74, the compound of Examples 75 was synthesized. Example 75 Synthesis of 2-[2-[3-[N-(Benzoxazol-2-yl)-N-2-phenoxyethyl]aminopropyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 474 (M+) Production Example 13 Synthesis of tert-Butyl 2-[4-(cyanomethyl)phenoxy]-2- methylpropionate (Figure Removed) 4-Hydroxyphenylacetonitrile (13.3 g, 100 mmol) and potassium carbonate (20.73 g, 150 mmol) were added to dimethylformamide (75 mL). Subsequently, tert-butyl 2-bromoisobutyrate (50.41 mL, 250 mmol) was added thereto, and the mixture was stirred for 24 hours at 80°C. The temperature of the reaction mixture was returned to room temperature, and ethyl acetate was added thereto. Washing was performed sequentially with water and brine, followed by drying over sodium sulfate. The resultant mixture was subjected to concentration under reduced pressure and purification by silica gel column chromatography (n-hexane/ethyl acetate = 7/1), whereby the target compound was obtained (18.62 g, 67.62 mmol, 67.6%). Production Example 14 Synthesis of tert-Butyl 2-[4-(2-aminoethyl)phenoxy]-2- methylpropionate (Figure Removed) tert-Butyl 2-[4-(cyanomethyl)phenoxy]-2-methylpropionate (5.50 g, 20.0 mmol) was dissolved in tetrahydrofuran (90 mL) . Subsequently, in a nitrogen atmosphere, borane-tetrahydrofuran complex in tetrahydrofuran solution [1.08M BH3-THF in THF (92.6 mL, 100 mmol)] was added thereto, and the mixture was stirred for three hours at 50°C. Subsequently, 1M hydrochloric acid was gradually added at 0°C, and the resultant mixture was stirred for one hour at room temperature. Thereafter, the reaction mixture was made basic with sodium carbonate. Tetrahydrofuran was evaporated, and then chloroform was added. Washing was performed sequentially with water and brine, followed by drying over sodium sulfate. The reaction mixture was subjected to concentration under reduced pressure and purification by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained (5.16 g, 13.02 mmol, 65.1%) . 1H-NMR(400MHz, CDC13) 5 1.45(s, 9H), 1.55 (s, 6H) , 2.67(t, J=7Hz, 2H) , 2.92( t, J=7Hz, 2H) , 6.80(dt, J = 9, 3 Hz, 2H) , 7.05(dt, J = 9, 3 Hz, 2H). Production Example 15 Synthesis of tert-Butyl 2-[4-[2-N-(benzoxazol-2- yl)aminoethyl]phenoxy]-2-methylpropionate (Figure Removed) tert-Butyl 2-[4-(2-aminoethyl)phenoxy]-2-methylpropionate (290 mg, 1.04 mmol) was dissolved in tetrahydrofuran (4 mL). Subsequently, diisopropylethylamine (272 p,L, 1.56 mmol), and then 2-chlorobenzoxazole (145 jaL, 1.25 mmol) were added thereto, and the mixture was stirred under argon atmosphere for 15 hours at room temperature. Ethyl acetate was added to the reaction mixture. Washing was performed sequentially with water and brine, followed by drying over sodium sulfate. The reaction mixture was subjected to filtration, concentration under reduced pressure, and separation by silica gel column chromatography (n-hexane/ethyl acetate = 10/1), whereby the target compound was obtained (367 mg, 0.925 mmol, 88.9%). Production Example 16 Synthesis of tert-Butyl 2-[4-[2-[N-(benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminoethyl]phenoxy]-2-methylpropionate (Figure Removed) tert-Butyl 2- [4-[2-N-(benzoxazol-2- yl)aminoethyl]phenoxy]-2-methylpropionate (50 mg, 0.126 mmol) was dissolved in acetonitrile (3 mL) . Subsequently, cesium carbonate (62 mg, 0.189 mmol) and 2-(4-chlorophenoxy)-1-bromoethane (59 mg, 0.252 mmol) were added thereto, and the mixture was stirred for 14 hours at 70°C. The temperature of the mixture was returned to room temperature, and ethyl acetate was added. The resultant mixture was sequentially washed with water and brine, followed by drying over sodium sulfate. The mixture was subjected to concentration under reduced pressure and purification by preparative TLC (silica gel, n-hexane/ethyl acetate = 10/1), whereby the target compound was obtained (26 mg, 0.0474 mmol, 37.6%). Examples 76 Synthesis of 2-[4-[2-[N-(Benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminoethyl]phenoxy]-2-methylpropionic acid (Figure Removed) tert-Butyl 2-[4-[2-[N-(benzoxazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminoethyl]phenoxy]-2-methylpropionate (26 mg, 0.0474 mmol) was dissolved in dichloromethane (6 mL). Subsequently, trifluoroacetic acid (0.5 mL) was added thereto, and the mixture was stirred for 5 hours at room temperature. The mixture was subjected to concentration under reduced pressure and toluene azeotrope. Thereafter, chloroform was added thereto, and the mixture was sequentially washed with water and brine, followed by drying over sodium sulfate. The resultant mixture was subjected to concentration under reduced pressure and purification by preparative TLC (silica gel, chloroform/methanol = 10/1), whereby the target compound was obtained (23 mg, 0.0467 mmol, 98.5%). MS(FAB) m/z : 495(M++1) In a manner similar to that described in Example 76, the compounds of Examples 77 through 79 were synthesized. Example 77 Synthesis of 2-[4-[2-[N-(Benzoxazol-2-yl)-N-2-phenoxyethyl]aminoethyl]phenoxy]-2-methylpropionic acid MS(m/z) 460 (M+) Example 78 Synthesis of 2- [3- [2-[N-(Benzoxazol-2-yl)-N-2- phenoxyethyl]aminoethyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 460 (M+) Example 79 Synthesis of 2-[3-[2-[N-(Benzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminoethyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(FAB) m/z : 495(M++1), 4 97 [ (M++l) +2, Production Example 17 Synthesis of 2-Methoxyphenylacetamide (Figure Removed) 2-Methoxyphenylacetic acid (10.0 g, 60.1 mmol) was dissolved in acetonitrile (15 mL). Subsequently, pyridine (2.84 g, 36.1 mmol) and di-tert-butyl dicarbonate [BOC20 (19.6 g, 90.2 mmol)] were added thereto. The mixture was stirred for 10 minutes at room temperature, and then ammonium hydrogencarbonate (7.1 g, 90.2 mmol) were added. After completion of reaction, the reaction mixture was concentrated under reduced pressure. Thereafter, the resultant concentrate was added to water, and the resultant mixture was extracted with chloroform, followed by washing sequentially with 1M hydrochloric acid and brine. The resultant mixture was subjected to drying over magnesium sulfate and concentration under reduced pressure. The resultant concentrate was used in Production Example 18 without purification. Production Example 18 Synthesis of 2-Hydroxyphenylacetamide (Figure Removed) 2-Methoxyphenyl acetamide (13.0 g, 78.6 mmol) was dissolved in methylene chloride (10.0 mL). Subsequently, 1.OM boron tribromide in methylene chloride solution (157 mL, 157 mmol) was slowly added dropwise under ice-cooling, and the mixture was stirred for one hour at room temperature. Subsequently, water was slowly added thereto under ice-cooling, and the mixture was stirred for 30 minutes. The mixture was extracted with chloroform, followed by washing the organic layer with brine, drying over anhydrous sodium sulfate. The reaction mixture was subjected to concentration under reduced pressure and purification by column chromatography (n-hexane/ethyl acetate = 20/1), whereby a white solid was obtained (1.8 g, 11.9 mmol, 15%). Production Example 19 Synthesis of tert-Butyl 2-[2-(aminocarbonylmethyl)phenoxy]-2-methylpropionate (Figure Removed) 2-Hydroxyphenyl acetamide (1.2 g, 7.93 mmol) was dissolved in acetonitrile (10 mL), and potassium carbonate (5.5 g, 39.6 mmol) was added to the solution. Subsequently, to the mixture, tert-butyl 2-bromoisobutyrate (8.9 g, 39.6 mmol) was added, followed by stirring at 80°C. After completion of reaction, water was added to the mixture. The resultant mixture was extracted with ethyl acetate, followed by washing the organic layer with water. The mixture was subjected to drying over sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (chloroform/methanol = 40/1), whereby the target compound was obtained (1.4 g, 4.87 mmol, 61%). 1H-NMR(400MHz, CDC13) 5 1.43 (s, 9H) , 1.65 (s, 6H) , 3.59 (s, 2H), 6.10-6.35 (br, 2H), 6.75 (d, J = 8 Hz, 1H), 6.94 (t, J = 7 Hz, 1H), 7.17 (t, J = 8 Hz, 1H), 7.25 (d, J = 7 Hz, 1H) Production Example 20 Synthesis of tert-Butyl 2-[2-(2-aminoethyl)phenoxy]-2-methylpropionate (Figure Removed) tert-Butyl 2-[2-(aminocarbonylmethyl)phenoxy]-2-methylpropionate (1.4 g, 4.87 mmol) was dissolved in tetrahydrofuran (5.0 mL). Subsequently, under nitrogen atmosphere, borane-THF complex in THF solution [1.OM BH3-THF in THF (14.6 mL, 14.6 mmol)] was added thereto, the mixture was stirred for three hours at 50°C. Thereafter, concentrated hydrochloric acid was gradually added thereto at 0°C. The resultant mixture was stirred for one hour at room temperature and made basic with an aqueous ethylamine solution. Ethyl acetate was added thereto. The mixture was sequentially washed with water and brine, followed by drying over sodium sulfate. The mixture was subjected to concentration under reduced pressure and purification by silica gel column chromatography (chloroform/methanol = 30/1), whereby the target compound was obtained (830 mg, 2.97 mmol, 61%) . 1H-NMR(400MHz, CDC13) 5 1.43 (s, 9H) , 1.65 (s, 6H), 2.09 (br s., 2H) , 2.79 (t, J = 7 Hz, 2H) , 2.97 (t, J = 7 Hz, 2H), 6.69 (d, J = 8 Hz, 1H), 6.88 (t, J = 7 Hz, 1H), 7.07 (d, J = 8 Hz, 1H), 7.14 (d, J = 7 Hz, 1H) Production Example 21 Synthesis of tert-Butyl 2-[2-[2-N-(benzoxazol-2- yl)aminoethyl]phenoxy]-2-methylpropionate (Figure Removed) tert-Butyl 2- [2- (2-aminoethyl) phenoxy] -2-methylpropionate (762 mg, 2.73 mmol) was dissolved in tetrahydrofuran (5.0 mL). Subsequently, diisopropylethylamine (422.6 mg, 3.27 mmol), and then 2- chlorobenzoxazole (502.4 mg, 3.27 mmol) were added thereto, and the mixture was stirred overnight at room temperature. Ethyl acetate was added to the reaction mixture. Washing was performed sequentially with water and brine, followed by drying over sodium sulfate. Thereafter, the reaction mixture was subjected to filtration, concentration under reduced pressure, and purification by silica gel column chromatography (n-hexane/ethyl acetate = 6/1), whereby the target compound was obtained (977 mg, 2.46 mmol, 90%). Production Example 22 Synthesis of tert-Butyl 2-[2-[2-[N-(benzoxazol-2-yl)-N-2-phenoxyethyl]aminoethyl]phenoxy]-2-methylpropionate (Figure Removed) tert-Butyl 2-[2-[2-(N-benzoxazol-2- yl)aminoethyl]phenoxy]-2-methylpropionate (157 mg, 0.40 mmol) was dissolved in acetonitrile (3.0 mL). Subsequently, cesium carbonate (282 mg, 0.87 mmol) and 2-phenoxyethyl bromide (160 mg, 0.80 mmol) were added thereto, and the mixture was stirred overnight at 80°C. The temperature of the reaction mixture was returned to room temperature, and ethyl acetate was added. Washing was performed sequentially with water and brine, followed by drying over sodium sulfate. The reaction mixture was subjected to concentration under reduced pressure and purification by silica gel column chromatography (n- hexane/ethyl acetate = 4/1), whereby the target compound was obtained (85.3 mg, 0.17 mmol, 41%). Production Example 80 Synthesis of 2-[2-[2-[N-(Benzoxazol-2-yl)-N-2- phenoxyethyl]aminoethyl]phenoxy]-2-methylpropionic acid (Figure Removed) tert-Butyl 2-[2-[2-[N-(benzoxazol-2-yl)-N-2- phenoxyethyl]aminoethyl]phenoxy]-2-methylpropionate (85.3 mg, 0.17 mmol) was dissolved in methylene chloride (3.0 mL). Subsequently, 50% trifluoroacetic acid in methylene chloride solution was added thereto, and the mixture was stirred for three hours at room temperature. The resultant mixture was subjected to concentration under reduced pressure and toluene azeotrope. Chloroform was added to the resultant mixture, and washing was performed sequentially with water and brine, followed by drying over sodium sulfate, concentration under reduced pressure, and purification by preparative TLC (silica gel, chloroform/methanol = 20/1), whereby the target compound was obtained (63.5 mg, 0.14 mmol, 81%). MS(m/z) 460 (M+) In a manner similar to that described in Example 80, the compound of Example 81 was synthesized. Production Example 81 Synthesis of 2-[2-[2-[N-(Benzoxazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminoethyl]phenoxy]-2-methylpropionic acid (Figure Removed) MS(m/z) 494 (M+), 496(M+ Production Example 23 Synthesis of 3-tert-Butyldimethylsilyloxybenzaldehyde 3-Hydroxybenzaldehyde (5.0 g, 40.9 mmol) was dissolved in acetonitrile (10.0 mL). Subsequently, potassium carbonate (11.3 g, 81.9 mmol), and then tert-butyldimethylchlorosilane (7.4 g, 49.1 mmol) were added thereto, and the resultant mixture was stirred at room temperature. After completion of reaction, ethyl acetate was added thereto, followed by washing sequentially with water and brine, and drying over anhydrous sodium sulfate. The reaction mixture was subjected to filtration, concentration under reduced pressure, and purification by silica gel column chromatography (n- hexane/ethyl acetate = 20/1), whereby the target compound was obtained (9.1 g, 94%). 1H-NMR(400MHz, CDC13) 5 0.00 (s, 6H) , 0.77 (s, 9H) , 6.88 (d, J = 8 Hz, 1H), 7.10 (s, 1H), 7.18 (t, J = 8 Hz, 1H), 7.25 (d, J = 8 Hz, 1H), 9.73 (s, 1H) Production Example 24 Synthesis of N-3-(4-Methoxyphenoxy)propyl-3-tert- butyldimethylsilyloxybenzylamine (Figure Removed) 3-tert-Butyldimethylsilyloxybenzaldehyde (1.5 g, 6.34 mmol) was dissolved in 1,2-dichloroethane (10.0 mL). Subsequently, 3-(4-methoxyphenoxy)propylamine (1.5 g, 8.25 mmol) was added thereto, and the resultant mixture was stirred for 20 minutes. At room temperature, sodium triacetoxyborohydride (1.75 g, 8.25 mmol) and acetic acid (495 mg, 8.25 mmol) were added thereto, and the mixture was stirred overnight. A saturated aqueous sodium hydrogencarbonate solution was added thereto. The reaction mixture was extracted with chloroform, and the organic layer was washed with brine. The resultant mixture was subjected to drying over anhydrous sodium sulfate, concentration under reduced pressure, and purification by silica gel chromatography (chloroform/methanol = 50/1), whereby the target compound was obtained (1.9 g, 78%). 1H-NMR(400MHz, CDC13) 5 0.00 (s, 6H) , 0.73 (s, 9H) , 1.81 (m, 2H), 2.66 (br. s, 2H) , 3.58 (s, 3H), 3.61 (s, 2H), 3.81 (t, J = 6 Hz, 2H ), 6.55 (d, J = 7 Hz, 1H), 6.63 (br. s, 5H) , 6.73 (d, J = 7 Hz, 1H), 6.99 (t, J = 7 Hz, 1H) Production Example 25 Synthesis of N-(Benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl-3-tert-butyldimethylsilyloxybenzylamine (Figure Removed) N-3-(4-methoxyphenoxy)propyl-3-tert- butyldimethylsilyloxybenzylamine (1.9 g, 5.0 mmol) was dissolved in A/,N-dimethylformamide (3.0 mL) . Subsequently, A7,A7-diisopropylethylamine (768 mg, 5.9 mmol) was added dropwise thereto. To the solution, 2-chlorobenzoxazole (912 mg, 5.94 mmol) was added. The mixture was stirred for 15 minutes at room temperature, and then stirred overnight at 70°C. The resultant mixture was extracted with ethyl acetate, followed by washing the organic layer with brine, drying over anhydrous sodium sulfate, and concentration under reduced pressure. The resultant mixture was subjected to purification by silica gel column chromatography (n- hexane/ethyl acetate = 10/1), whereby the target compound was obtained (1.9 g, 73%). 1H-NMR(400MHz/ CDC13) 5 0.05 (s, 9H), 0.85 (s, 6H), 1.97-2.03 (m, 2H), 3.60 (t, J = 7 Hz, 2H) , 3.67 (s, 3H) , 3.87 (t, J = 6 Hz, 2H), 4.63 (s, 2H) , 6.65-6.80 (m, 7H), 6.91 (t, J = 7 Hz, 1H), 7.05-7.09 (m, 2H) , 7.12 (d, J = 8 Hz, 1H), 7.27 (d, J = 8 Hz, 1H) Production Example 26 Synthesis of N-(Benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl-3-hydroxybenzylamine (Figure Removed) N- (Benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl-3-tert-butyldimethylsilyloxybenzylamine (1.9 g, 3.6 mmol) was dissolved in solvent mixture of A/,A7-dimethylformamide/H20 (10/1) (5.0 mL) . Subsequently, cesium carbonate (1.2 g, 3.6 mmol) was added thereto. The mixture was stirred for 3 hours at room temperature, followed by concentration under reduced pressure. Hydrochloric acid (1.0 mol/L) was added thereto. The resultant mixture was extracted with ethyl acetate, followed by washing the organic layer with brine, drying over anhydrous sodium sulfate, and concentration under reduced pressure. The resultant mixture was subjected to purification by silica gel chromatography (n-hexane/ethyl acetate = 5/1), whereby the target compound was obtained (1.3 g, 89%) . xH-NMR(400MHz, CDC13) 5 1.98 (quintet, J = 7 Hz, 2H), 3.37 (t, J = 7 Hz, 2H), 3.75 (s, 3H), 3.86 (t, J = 6 Hz, 2H), 4.61 (s, 2H), 6.65 - 6.81 (m, 7H), 6.90 - 7.13 (m, 5H) Production Example 27 Synthesis of Ethyl (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionate (Figure Removed) N- (Benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl-3-hydroxybenzylamine (244 mg, 0.6 mmol) was dissolved in toluene (5.0 mL) . Subsequently, (S)-ethyl lactate (78.4 mg, 0.66 mmol) and triphenylphosphine (174 mg, 0.66 mmol) were added thereto. Under argon atmosphere, a 40% diethylazodicarboxylate in toluene solution (289 mL, 0.66 mmol) was slowly added thereto at 0°C, and the mixture was stirred at room temperature. After completion of reaction, the resultant mixture was subjected to concentration under reduced pressure, followed by addition of water, extraction with ethyl acetate, and washing the organic layer with brine. The mixture was dried over anhydrous sodium sulfate, followed by concentration under reduced pressure and purification by silica gel chromatography (n-hexane/ethyl acetate = 9/1), whereby the target compound was obtained (180 mg, 60%). 1H-NMR(400MHz, CDC13) 5 1.16 (t, J = 7 Hz, 3H), 1.56 (d, J = 7 Hz, 3H) , 2.12 (quintet, J = 7 Hz, 2H) , 3.67 (t, J = 7 Hz, 2H) , 3.74 (s, 3H) , 3.94 (t, J = 6 Hz, 2H) , 4.07 - 4.18 (m, 2H), 4.68 (q, J = 7 Hz, 1H), 4.72 (s, 2H), 6.75 (d, J = 8 Hz, 1H) , 6.79 (s, 4H), 6.83 (br. s, 1H) , 6.88 (d, J = 8 Hz, 1H) , 6.99 (t, J = 8 Hz, 1H), 7.14 (t, J = 8 Hz, 1H) , 7.18 - 7.22 (m, 2H), 7.35 (d, J = 8 Hz, 1H) Example 82 Synthesis of (R)-2-[3-[[N-(Benzoxazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionic acid (Figure Removed) Ethyl (R)-2-[3-[[N-(benzoxazol-2-yl)-N-(3-(4- methoxyphenoxy)propyl)aminomethyl]phenoxy]propionate (180 mg, 0.36 mmol) was dissolved in solvent mixture of tetrahydrofuran/H20 (6/1) (4.0 mL). Subsequently, lithium hydroxide-H20 (25.9 mg, 0.43 mmol) was added thereto, and the mixture was stirred for one hour at 0°C. Under ice-cooling, the resultant mixture was acidified with aqueous 1M HC1 solution, and then subjected to extraction with ethyl acetate and sequentially washing with water and brine. The mixture was dried over sodium sulfate, followed by concentration under reduced pressure and purification by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained (112 mg, 65%). ^-NMR(400MHz, CDC13) 5 1.40 (br.s, 3H) , 1.98-2.03 (m, 2H) , 3.58 (t, J = 7 Hz, 2H), 3.70 (s, 3H), 3.84 (t, J = 6 Hz, 2H) , 4.55 (br.s, 1H), 4.59 (s, 2H) , 6.70 - 6.81 (m, 7H), 6.93 (t, J = 8 Hz, 1H), 7.03 - 7.14 (m, 3H), 7.31 (d, J = 8 Hz, 1H) In a manner similar to that described in Example 82, the compounds of Example 83 through 88 were synthesized. Example 83 Synthesis of (R) -2- [ [ 3- [N- (Benzoxazol-2-yl) -A7-3-phenoxypropyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR (400 MHz, CDC13) 6 0.99(t, J = 7 Hz, 3H), 1.91(quintet, J = 7 Hz, 2H), 1.99 (quintet, J = 7 Hz, 2H), 3.53 (td, J = 7, 2 Hz, 2H), 3.85 (t, J = 4 Hz, 2H), 4.46 (t, J = 6 Hz, 1H), 4.53 (d, J = 16 Hz, 1H), 4.61 (d, J = 16 Hz, 1H), 6.73-6.78(m, 5H), 6.85 (t, J = 7 Hz, 1H), 6.92(t, J = 7 Hz, 1H), 7.05-7.19 (m, 5H), 7.28(d, J = 7 Hz, 1H). Example 84 Synthesis of (R) -2- [ [3- [N- (Benzoxazol-2-yl) -A7-2- (4- chlorophenxy)ethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR (400 MHz, DMSO-d6) 8 0.95(t, J = 7 Hz, 3H) , 1.77-1.88(m, 2H) , 3.87 (t, J = 6 Hz, 2H) , 4.23 (t, J = 5 Hz, 2H), 4.57 (br.s, 1H), 4.82 (s, 2H) , 6.76 (d, J = 8 Hz, 1H), 6.87-6.93 (m, 3H), 7.01 (t, J = 8 Hz, 1H), 7.16 (t, J = 8 Hz, 2H) , 7.23 (t, J = 8 Hz, 1H), 7.28-7.32(m, 3H), 7.40 (d, J = 8 Hz, 1H) . Example 85 Synthesis of (R) -2- [[ 3- [N- (Benzoxazol-2-yl) -A7-3- (4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR (400MHz, CD3OD) 5 0.94 (t, J=7.4 Hz, 3H), 1.81(m, 2H), 1.99(quintet,, J= 6.1 Hz, 2H) , 3.60(t, J=6.8 Hz, 2H), 3.61(s, 3H), 3.85 (t, J= 5.9 Hz, 2H) , 4.40(t, J= 5.9 Hz, 1H) , 4.65 (s, 2H) , 6.69-6.80 (m, 7H) , 6.91 (dt, J=7.2, 1.0 Hz, 1H) , 7.05(dt, J=7.2, 1.2 Hz, 1H), 7.12-7.18 (m, 4H) . Example 86 (Figure Removed) ynthesis of (R) -2- [ [ 3- [N- (Benzoxazol-2-yl) -A7-2- ( 4-fluorophenoxy)ethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR (400 MHz, DMSO-d6) 8 0.94(t, J = 7 Hz, 3H) , 1.77-1.82(m, 2H), 3.86 (t, J = 6 Hz, 2H), 4.21(t, J = 6 Hz, 2H), 4.46 (br.s, 1H), 4.81 (s, 2H), 6.75 (d, J = 9 Hz, 1H), 6.87-6.93 (m, 4H), 7.02 (t, J = 8 Hz, 1H), 7.06 (t, J = 9 Hz, 2H) , 7.16 (t, J = 8 Hz, 1H), 7.21(t, J = 8 Hz, 1H), 7.30 (d, J = 8 Hz, 1H), 7.40 (d, J = 8 Hz, 1H). Example 87 Synthesis of (R) -2- [ [3- [N- (Benzoxazol-2-yl) -A7-3- (4-fluorophenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) 1H NMR (400 MHz, DMSO-d6, 60°C) 6 0.94(t, J = 7 Hz, 3H) , 1.73-1.88(m, 2H), 2.06 (quintet, J = 7 Hz, 2H), 3.65 (t, J = 7 Hz, 2H), 3.98 (t, J = 7 Hz, 2H), 4.35 (t, J = 7 Hz, 1H), 4.70 (s, 2H), 6.76 (d, J = 8 Hz, 1H), 6.86-6.92 (m, 4H), 6.97 (t, J = 8 Hz, 1H), 7.04 (t, J = 8 Hz, 2H), 7.12 (t, J = 8 Hz, 1H), 7.17 (t, J = 8 Hz, 1H), 7.26 (d, J = 8 Hz, 1H), 7.31(d, J = 8 Hz, 1H). Example 88 (R)-2-[[3-[N- (Benzoxazol-2-yl)-N-3-phenoxypropyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR (400 MHz, DMSO-d6) 5 1.46 (d, J = 7 Hz, 3H) , 2.09(quintet, J = 7 Hz, 2H), 3.66 (t, J = 7 Hz, 2H), 4.00 (t, J = 6 Hz, 2H), 4.73 (s, 2H) , 4.78 (q, J = 7 Hz, 1H), 6.78(dd, J = 8, 2Hz, 1H), 6.86 (Br.s, 1H), 6.90-6.93(m, 4H), 6.98 (td, J = 8, IHz, 1H), 7.14 (td, J = 8, IHz, 1H), 7.23-7.34(m, 5H) . Production Example 28 Synthesis of Ethyl 3-[[3-[N-(benzoxazol-2-yl)-W-3-phenylsulfinylpropyl]aminomethyl]phenoxy]propionate (Figure Removed) m-Chloroperbenzoic acid (18 mg, 0.1 mmol) was added to ethyl 3-[[3-[N-(benzoxazol-2-yl)-N-3- phenylthiopropyl]aminomethyl]phenoxy]propionate (50.0 mg, 0.1 mmol)in a methylene chloride solution at room temperature, and the mixture was stirred for 2 hours. After completion of reaction, the reaction solution was added to 10% sodium thiosulfate solution(10 ml) and extracted with chloroform, to obtain an organic layer. The extracted organic was washed with saturated aqueous sodium hydrogencarbonate and dried over sodium sulfate, followed by removing the solvent under reduced pressure. The pale yellow oily compound thus obtained was purified by silica gel chromatography (n-hexane/ethyl acetate = 1:1), whereby the target compound was obtained as a colorless oil (49 mg, 0.096 mmol, 96.3%). 1H NMR (400 MHz, CDC13) 6 : 1.19(t, J=7Hz, 3H), 1.58(d, J=7Hz, 3H), 1.97-2.16(m, 2H) , 2.72-2.91(m, 2H) , 3.55-3.69(m, 2H) , 4.12-4.21(m, 2H), 4.64-4.74(m, 3H) , 6.78(d, J= 8Hz, 1H) , 6.81(3, 1H) , 6.86(d, J=8Hz, 1H) , 7.03(t, J=8Hz, 1H) , 7.16-7.27(m, 3H), 7.35(d, J=8Hz, 1H) , 7.47-7.56(m, 5H). Example 89 Synthesis of 3-[[3-[N-(Benzoxazol-2-yl)-N-3-phenylsulfinylpropyl]aminomethyl]phenoxy]propionic acid (Figure Removed) Ethyl 3- [ [3- [N- (Benzoxazol-2-yl) -A7-3- phenylsulfinylpropyl]aminomethyl]phenoxy]propionate (49 mg, 0.096 mmol) was dissolved in ethanol (1 ml). The mixture was added to a 1M sodium hydroxide solution and stirred at 80°C for 1 hour. The reaction solution was condensed under educed pressure, and saturated ammonium chloride was added thereto, followed by the extraction with chloroform. The extracted chloroform layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure, and thereafter purified by a preparative TLC (silica gel, chloroform /methanol = 10/1). The target compound was thus obtained (45 mg, 98.0%) . XH NMR (400 MHz, CD3OD) 8 1.53(d, J = 7 Hz, 3H), 1.89-2.10(m, 2H), 2.81-3.10 (m, 2H) , 3.61(t, J = 7 Hz, 2H) , 4.63-4.75(m, 3H), 6.79-6.86(m, 3H) , 7.04(t, J = 8 Hz, 1H), 7.17(t, J = 8 Hz, 1H), 7.19(t, J = 8 Hz, 1H), 7.27(d, J = 8 Hz, 1H), 7.31(d, J = 8 Hz, 1H), 7.52-7.61(m, 5H). In a manner similar to that described in Example 89, the compounds of Examples 90 and 91 were synthesized. Example 90 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3-benzenesulfinylpropyl]aminomethyl]phenoxy]butyric acid (Figure Removed) 1R NMR (400 MHz, CD3OD) 8 1.03(t, J = 7Hz, 3H), 1.89-2.05(m, 4H), 2.80-3.00(m, 2H), 3.59(t, J = 7 Hz, 2H), 4.49(t, J = 6 Hz, 1H) , 4.68(s, 2H) , 6.80-6.86(m, 3H) , 7.03(t, J = 8 Hz, 1H), 7.15(d, J = 8 Hz, 1H), 7.19(d, J = 8 Hz, 1H), 7.27(d, J = 8 Hz, 1H) , 7.30(d, J = 8 Hz, 1H), 7.50-7.59(m, 5H) . Example 91 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-3- benzenesulfonylpropyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR (400 MHz, CD3OD) 8 1.52(d, J = 7 Hz, 3H) , 1.98 (quintet, J = 7 Hz, 2H), 3.21(t, J = 7 Hz, 2H), 3.58(t, J= 7 Hz, 2H), 4.64-4.67(m, 3H), 6.78-6.84(m, 3H), 7.04(t, J = 8 Hz, 1H), 7.16(t, J = 8 Hz, 1H) , 7.19(t, J = 8 Hz, 1H) , 7.27(d, J = 8 Hz, 1H), 7.31(d, J = 8 Hz, 1H), 7.58(t, J = 8 Hz, 2H), 7.67(t, J = 7 Hz, 1H), 7.85(d, J = 8 Hz, 2H). Production example 29 Synthesis of 4-Azidobutyrophenone (Figure Removed) 4-Chlorobutyrophenone (300.0 mg, 1.64 mmol) was dissolved in A7,W-dimethylformamide (20 ml) at room tempaerature and then added to sodium azide (1.07 g, 16.42 mmol)at the same temperature, and thereafter stirred at 100°C for 24 hours. The reaction solution was added to a saturated aqueous sodium hydrogencarbonate solution and then extracted by ethyl acetate, to obtain an organic layer. The extracted organic layer was washed with water and brine sequentially, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant saubstance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 5/1), whereby the target compound was obtained as a colorless oil (285.5 mg, 91.9 %). lti NMR (400MHz, CDC13) 8 2.05 (quintet, J= 7 Hz, 2H), 3.09 (t, J= 1 Hz, 2H), 3.43 (t, J= 7 Hz, 2H) , 7.48 (t, J= 8 Hz, 2H) , 7.58 (t, J= 8 Hz, 2H), 7.97 (dd, J= 6 , 1 Hz, 1H). Production example 30 Synthesis of 4,4-Ethylenedioxy-4-phenylbutylazide (Figure Removed) 4-Azidobutyrophenone (100.0 mg, 0.53 mmol) was dissolved in toluene (5 ml) at room temperature, and thereto were added ethylene glycol (0.06 ml, 1.06 mmol) and p-toluene sulfonic acid -mono hydrate (10.1 mg, 0.05 mmol) in sequential order at the same temperature, and thereafter, the mixture was refluxed using a Dean Stark tube for 24 hours. The reaction solution was cooled to room temperature and added to water thereafter, followed by the extraction using ethyl acetate. The extracted organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The target compound was thus obtained as a colorless oil (133 mg). XH NMR (400MHz, CDC13) 8 1.67 (quintet, J= 7 Hz, 2H) , 1.94-1.98 (m, 2H), 3.26 (t, J= 7 Hz, 2H) , 3.78 (t, J= 7 Hz, 2H) , 4.02 (t, J= 7 Hz, 2H), 7.31-7.37 (m, 3H), 7.45 (dd, J= 7, 1 Hz, 2H). Production Example 31 Synthesis of 4,4-Ethylenedioxy-4-phenylbutylamine (Figure Removed) 4,4-Ethylenedioxy-4-phenylbutylazide(130.0 mg, 0.56 mmol) was dissolved in tetrahydrofuran (5 ml), and thereto were added water (0.01 ml, 0.56 mmol) and triphenylphosphine (146.2 mg, 0.56 mmol) in a tetrahydrofuran solution (2 ml) in sequential order at the same temperature, and thereafter, the solution was stirred at room temperature for 24 hours. The reaction solution was added to a saturated aqueous sodium hydrogencarbonate solution and then extracted by chloroform, to obtain an organic layer. The extracted organic was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained as a colorless oil (61.8 mg, 56.4% for 2 steps ). XH NMR (270MHz, CDC13) 8 1.47 (quintet, J= 1 Hz, 2H) , 1.89 (t, J= 1 Hz, 2H), 2.14 (br.s, 2H) , 2.63 (t, J= 7 Hz, 2H) , 3.57-3.83 (m, 2H), 3.85-4.10 (m, 2H), 7.26-7.67 (m, 5H) . Production Example 32 Synthesis of tert-Butyl 2-[3-[N-(4,4-ethylenedioxy-4-phenylbutyl)aminomethyl]phenoxy]butyrate (Figure Removed) 4,4-Ethylenedioxy-4-phenylbutylamine(27.0 mg, 0.13 mmol) was dissolved in chloroform (3 ml)at room temperature, and thereto were added tert-butyl 2-(3-formylphenoxy)butyrate (34.4 g, 0.13 mmol) in a chloroform solution (2 ml) and sodium triacetoxyborohydride (41.4 mg, 0.20 mmol) in sequential order at the same temperature, and thereafter, the mixture was stirred at room temperature for 12 hours. The reaction solution was added to a saturated aqueous sodium hydrogencarbonate solution and thereafter extracted by chloroform. The extracted organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained as a colorless oil (38.5 mg, 64.9%). 1R NMR (270MHz, CDC13) 6 1.06 (t, J= 7 Hz, 3H), 1.42 (s, 9H), 1.56 (quintet, J= 7 Hz, 2H), 1.81-2.05 (m, 4H), 2.24 (br.s, 1H) , 2.59 (t, J= 7 Hz, 2H), 3.62-3.82 (m, 4H), 3.99 (s, 2H), 4.43 (t, J= 6 Hz, 1H), 6.70-6.89 (m, 3H), 7.15-7.41 (m, 6H). Production Example 33 Synthesis of tert-Butyl 2-[3-[[N-(benzoxazol-2-yl)-N-(4,4-ethylenedioxy-4-phenylbutyl)]aminomethyl] phenoxy]butyrate (Figure Removed) tert-Butyl 2-[3-[N-(4,4-ethylenedioxy-4- phenylbutyl)]aminomethyl]phenoxy]butyrate (38.0 mg, 0.08 mmol) was dissolved in N,A7-dimethylformamide (5 ml) at room temperature, and the mixture was completely dissolved by adding diisopropylethylamine (0.022 ml, 0.13 mmol) thereto, followed by dropwise adding 2-chlorobezoxazole (0.014 ml, 0.13 mmol) thereto. The resultant mixture was stirred at 80°C for 1 hour and then cooled down to room temperature. The reaction solution was added to water and thereafter subjected to the extraction using ethyl acetate. The extracted organic layer was washed with water and brine sequentially, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1), whereby the target compound was obtained as a colorless oil (47.8 mg, 100%). XH NMR (270MHz, CDC13) 6 1.06 (t, J= 7 Hz, 3H) , 1.38 (s, 9H) , 1.70-1.95 (m, 6H) , 3.48 (t, J= 7 Hz, 2H) , 3.68-3.72 (m, 2H) , 3.92-4.04 (m, 2H), 4.40 (t, J= 7 Hz, 1H), 4.69 (s, 2H) , 6.74-6.85 (m, 3H), 7.00(t, J= 1 Hz, 1H), 7.12-7.43 (m, 9H). Production Example 34 Synthesis of tert-Butyl 2-[3-[[N-(benzoxazol-2-yl)-N-(4-oxo-4-phenylbutyl)]aminomethyl] phenoxy]butyrate (Figure Removed) tert-Butyl 2-[3-[[N-(benzoxazol-2-yl)-N-(4,4-ethylenedioxy-4-phenylbutyl)]aminomethyl]phenoxy]butyrate (48.0 mg, 0.08 mmol) was dissolved in acetone/water (10:1, 5.5 ml) at room temperature, and pyridinuim p-toluenesufonate (2.2 mg, 0.01 mmol) was added thereto at the same temperature, and thereafter, the mixture was refluxed for 24 hours. The reaction solution was cooled to room temperature and then added to water, followed by the extraction using ethyl acetate. The extracted organic layer was washed with water and brine sequentially, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1), whereby the target compound was obtained as a colorless oil (40.6 mg, 89.8%). XH NMR (400MHz, CDC13) 5 1.03 (t, J= 7 Hz, 3H), 1.35 (s, 9H) , 1.91 (quintet, J= 7 Hz, 2H) , 2.12 (quintet, J= 7 Hz, 2H) , 2.99 (t, J= 7 Hz, 2H), 3.59 (t, J= 7 Hz, 2H) , 4.39 (t, J= 6 Hz, 1H) , 4.74 (dd, J= 16, 20 Hz, 2H), 6.75 (d, J= 8 Hz, 1H), 6.85 (s, 1H) , 6.90(d, J= 8 Hz, 1H) , 6.96(t, J= 8 Hz, 1H) , 7.12 (t, J= 8 Hz, 2H) , 7.19 (t, J= 8 Hz, 1H) , 7.31 (d, J= 8 Hz, 1H ), 7.38 (t, J= 8 Hz, 2H ), 7.49 (t, J= 8 Hz, 1H) , 7.87 (d, J= 1 Hz, 2H). Example 92 Synthesis of 2-[3- [ [N-(Benzoxazol-2-yl)-N-(4-oxo-4- phenylbutyl)]aminomethyl]phenoxy]butyric acid (Figure Removed) tert-Butyl 2-[3-[[N-(benzoxazol-2-yl)-N-(4-oxo-4- phenylbutyl)]aminomethyl]phenoxy]butyrate (40.0 mg, 0.08 mmol) was dissolved in dichloromethane (2 ml) at room temperature, and trifluoroacetic acid (2 ml) was dropwise added thereto at 0°C. Thereafter, the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure and added by toluene (1 ml), and then subjected to the azeotropy of trifluoroacetic acid under reduced pressure. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained as a white solid (35.8 mg, 100%). XH NMR (400 MHz, CD3OD) 8 0.93(t, J=7Hz, 3H) , 1.76-1.84 (m, 2H), 1.98(quintet, J=7Hz, 2H) , 2.95(t, J=7Hz, 2H) , 3.50(t, J=7Hz, 2H) , 4.40(t, J=6Hz, 1H) , 4.64(s, 2H) , 6.72(d, J=7Hz, 1H) , 6.81(d, J=7Hz, 2H) , 6.89(t, J=8Hz, 1H) , 7.03(t, J=8Hz, 1H), 7.11(t, J=8Hz, 3H) , 7.31(t, J=8Hz, 2H) , 7.42(t, J=7Hz, 1H), 7.80(d, J=8Hz, 2H). In a manner similar to that described in Example 92, the compound of Example 93 was synthesized. Example 93 Synthesis of 2-[3-[[N-(Benzoxazol-2-yl)-N-(4-oxo-4- phenylbutyl)]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR (400 MHz, CD3OD) 8 1.52(d, J = 7 Hz, 3H) , 2.07 (quintet, J = 7 Hz, 2H) , 3.03(t, J = 7 Hz, 2H) , 3.59(t, J= 7 Hz, 2H) , 4.67-4.73(m, 3H) , 6.80(d, J = 9 Hz, 1H) , 6.91(d, J = 7 Hz, 2H) , 6.98(t, J = 8 Hz, 1H) , 7.12(t, J = 8 Hz, 1H) , 7.21(t, J = 8 Hz, 3H) , 7.40(t, J = 8 Hz, 2H) , 7.51(t, J = 7 Hz, 1H) , 7.80(d, J = 8 Hz, 2H) . Production Example 35 Synthesis of tert-Butyl 2-[3-[N-(3-hydroxypropyl) aminomethyl] phenoxy] butyrate (Figure Removed) tert-Butyl 2- (3-f ormylphenoxy) butyrate (105.1 mg, 0.42 rtimol) was dissolved in chloroform (10 ml) at room temperature, and thereto were added 3-amino-l-propanol (0.04 ml, 0.47 mmol), sodium triacetoxyborohydride (134.6 mg, 0.63 mmol) and acetic acid (0.03 ml, 0.51 mmol) in sequential order at the same temperature, and then stirred at room temperature for 24 hours. The reaction mixture was added to a saturated aqueous sodium hydrogencarbonate solution and thereafter extracted by chloroform, to obtain an organic layer. The extracted organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressured. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained as a colorless oil (43.3 mg, 33.3%). XH NMR (400MHz, CDC13) 8 1.43 (s, 9H) , 1.57 (d, J= 7 Hz, 3H), 1.73 (quintet, J= 6 Hz, 2H), 2.88 (t, J= 1 Hz, 2H), 3.77-3.80 (m, 4H), 4.29 (br.s, 2H), 4.63 (q, J= 1 Hz, 1H) , 6.75 (dd, J= 8, 3 Hz, 1H), 6.84 (s, 1H) , 6.91 (d, J= 8 Hz, 1H) , 7.22 (t, J= 8 Hz, 1H). Production Example 36 Synthesis of tert-Butyl 2-[3-[[N-(benzoxazol-2-yl)-N-3-hydroxypropyl]aminomethyl]phenoxy] butyrate (Figure Removed) hydroxypropyl)aminomethyl]phenoxy]butyrate (43.0 mg, 0.14 mmol) was dissolved in JV,.A/-dimethylformamide (5 ml) at room temperature, and the mixture was completely dissolved by adding diisopropylethylamine (0.02 ml, 0.21 mmol) thereto, followed by dropwise adding 2-chlorobezoxazole (0.02 ml, 0.21 mmol) thereto. The reaction mixture was stirred at 80°C for 20 hours and then cooled to room temperature. The reaction solution was added to water and thereafter subjected to the extraction using ethyl acetate. The extracted organic layer was washed with water and brine sequentially, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1), whereby the target compound was obtained as a colorless oil (47.9 mg, 80.2%) . 1H NMR (400MHz, CDC13) 6 1.38 (s, 9H) , 1.55 (d, J= 7 Hz, 3H) , 1.74 (quintet, J= 6 Hz, 2H) , 3.58 (t, J= 5 Hz, 2H) , 3.68 (t, J= 6 Hz, 2H) , 4.60 (q, J= 7 Hz, 1H) , 4.67 (s, 2H) , 4.92 (br.s, 1H), 6.77 (d, J= 8 Hz, 1H) , 6.83 (s, 1H) , 6.89 (d, J= 8 Hz, 1H) , 7.02 (t, J= 8 Hz, 1H), 7.16 (t, J= 8 Hz, 1H) , 7.21-7.26 (m, 2H) , 7.32 (d, J= 8 Hz, 1H) . Production Example 37 tert-Butyl 2- [3- [ [N- (benzoxazol-2-yl) -N-3-phthalimidopropyl] aminomethyl] phenoxy] butyrate (Figure Removed) tert-Butyl 2- [3- [ [N- (benzoxazol-2-yl) -N-3-hydroxypropyl] aminomethyl] phenoxy] butyrate (47.0 mg, 0.11 mmol), Potassium phthalimido (19 . 5 mg, 0.13 mmol), triphenylphosphine (34.7 mg, 0.13mmol) were dissolved in tetrahydrof uran (5 ml), and diethylazodicarboxylate (0.06 ml, 0.13 mmol) was dropwise added thereto at 0°C. The reaction solution was stirred for 3 hours and added to water, followed by the extraction using ethyl acetate. The extracted organic layer was washed with brine and dried over anhydrous sodium sulfate. The reaction solution was filtered and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1), whereby the target compound was obtained as a colorless oil (61.2 mg, 100%). XH NMR (400MHz, CDC13) 6 1.38 (s, 9H) , 1.55 (d, J= 7 Hz, 3H), 2.07 (quintet, J= 7 Hz, 2H), 3.57 (t, J= 7 Hz, 2H), 3.74 (t, J= 7 Hz, 2H) , 4.58 (q, J= 7 Hz, 1H) , 4.78 (s, 2H) , 6.73 (d, J= 8 Hz, 1H) , 6.82 (s, 1H) , 6.86 (d, J= 8 Hz, 1H) , 6.99 (t, J= 8 Hz, 1H), 7.12-7.20 (m, 3H), 7.29 (t, J= 8 Hz, 1H), 7.70-7.76 (m, 2H), 7.81-7.87 (m, 2H). Production Example 38 Synthesis of tert-Butyl 2-[3-[[N-3-aminopropyl-N-(benzoxazol-2-yl)]aminomethyl]phenoxy]butyrate (Figure Removed) tert-Butyl 2-[3-(N-(benzoxazol-2-yl)-N-3- phthalimidopropyl)aminomethyl]phenoxy]butyrate (60 mg, 0.11 mmol) was dissolved in ethanol (10 ml) at room temperature, and thereto was added hydrazine monohydrate (0.03 ml, 0.55 mmol). The mixture was stirred at 80°C for 24 hours. The reaction solution was concentrated under reduced pressure and saturated aqueous sodium hydrogencarbonate solution was added (Figure Removed) herein, and thereafter extracted by ethyl acetate to obtain an organic layer. The extracted organic layer was washed with brine, concentrated under reduced pressure, and purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1), whereby the target compound was obtained as a colorless oil (31.0 mg, 63.8%) . 1H NMR (400MHz, CDC13) 5 1.42 (s, 9H) , 1.57 (d, J= 7 Hz, 3H), 1.88-1.98 (m, 2H) , 3.20-3.33 (m, 4H) , 4.62 (q, J= 7 Hz, 1H), 4.69 (s, 2H), 5.80 (br.s, 2H), 6.74 (d, J= 7 Hz, 2H) , 6.81 (s, 1H), 6.80-7.02 (m, 3H), 7.22-7.26 (m, 2H). Production Example 39 Synthesis of tert-Butyl 2-[3-[[ N-(benzoxazol-2-yl)]-N-3-bis(benzenesulfonyl)aminopropyl]aminomethyl]phenoxy) butyrate (Figure Removed) tert-Butyl 2-[3-[[N-3-aminopropyl-N-(benzoxazol-2-yl-)]aminomethyl]phenoxy]butyrate (30.0 mg, 0.068 mmol) was dissolved in tetrahydrofuran (2 ml) at room temperature, and thereto were added benzenesulfonyl chloride (0.009 ml, 0.068 mmol) and triethylamine (0.009 mg, 0.068 mmol) in sequential order at the same temperature, and then stirred at room temperature for 24 hours. Thereafter, the reaction mixture was added to water and then extracted by ethyl acetate, to obtain an organic layer. The extracted organic was washed with brine and dried over anhydrous sodium sulfate. The reaction solution was filtered, concentrated under reduced pressure, and purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1) , whereby the target compound was obtained as a colorless oil (26.6 mg, 55.4%). (26.6mg, 55.4%) XH NMR (400MHz, CDC13) 8 1.44 (s, 9H) , 1.60 (d, J= 7 Hz, 3H) , 2.11 (quintet, J= 7 Hz, 2H) , 3.19 (t, J= 1 Hz, 2H) , 3.74 (t, J= 7 Hz, 2H), 4.48 (dd, J= 15, 24 Hz, 2H) , 4.71 (q, J= 1 Hz, 1H), 6.72-6.80 (m, 3H) , 6.89 (s, 1H) , 7.03 (t, J= 8 Hz, 2H) , 7.08 (dt, J= 7, 2 Hz, 1H) , 7.15 (d, J= 7 Hz, 2H) , 7.21 (t, J= 8 Hz, 2H) , 7.28 (t, J= 8 Hz, 2H) , 7.35-7.42 (m, 2H) , 7.56 (t, J= 8 Hz, 1H), 7.69 (d, J= 1 Hz, 2H) . Production Example 40 Synthesis of 2-[3-[[ N- (Benzoxazol-2-yl) ] -N-3-bis (benzenesulf onyl) aminopropyl] aminomethyl] phenoxy ) butyric acid (Figure Removed) tert-Butyl 2-[3-[[N-(benzoxazol-2-yl)-N-3-(N',N'-bis(benzenesulfonyl)amino)propyl]aminomethyl]phenoxy]butyrate (26.0 mg, 0.037 mmol) was dissolved in dichloromethane (2 ml) at room temperature, and thereto was dropwise added trifluoroacetic acid (2 ml) at 0°C. Thereafter, the mixture was stirred at room temperature for 3 hours. The reaction solution was concentrated under reduced pressure and added by toluene (1 ml), and then subjected to the azeotropy of trifluoroacetic acid under reduced pressure. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained as a white solid (23.9 mg, 100%). lti NMR (400MHz, CD3OD) 8 1.52 (d, J= 7 Hz, 3H), 1.78 (quintet, J= 7 Hz, 2H), 2.88 (t, J= 6 Hz, 2H) , 3.49 (t, J= 1 Hz, 2H) , 4.61 (q, J= 7 Hz, 1H), 4.66 (s, 2H), 6.73-6.83 (m, 4H), 6.91-6.98 (m, 1H) , 7.06 (t, J= 8 Hz, 1H) , 7.15-7.32 (m, 6H), 7.46 (t, J= 8 Hz, 2H) , 7.54 (t, J= 7 Hz, 1H) , 7.67-7.70 (m, 1H) , 7.79 (d, J= 8 Hz, 2H). Example 94 Synthesis of 2-[3-[[N-3-Benzenesulfonamidopropyl-N-(benzoxazol-2-yl)]aminomethyl]phenoxy]butyric acid (Figure Removed) 2-[3-[[N-(benzoxazol-2-yl)-N-3-(N',N'- bis(benzenesulfonyl)amino)propyl]aminomethyl]phenoxy]butyrate (23.9 mg, 0.037 mmol) was dissolved in ethanol (2 ml), and a 4N-sodium hydroxide solution (1 ml) was dropwise added thereto at 0°C. Thereafter, the solution was stirred at room temperature for 24 hours. The reaction solution was concentrated under reduced pressure and extracted with a 1N- hydrochloric acid solution, to obtain an organic layer. The extracted organic layer was washed with brine and dried over anhydrous sodium sulfate. The reaction solution was filtered and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 10/1), whereby the target compound was obtained as a white solid (14.1 mg, 78.2%). XH NMR (400 MHz, CD3OD) 8 1.43(d, J=7Hz, 3H) , 1. 69 (quintet, J=7Hz, 2H), 2.78(t, J=7Hz, 2H) , 3.40(t, J=7Hz, 2H), 4.54(q, J=7Hz, 1H), 4.57(s, 2H), 6.70-6.75(m, 3H), 6.95(t, J=7Hz, 1H), 7.08(t, J=7Hz, 1H), 7.11(t, J=8Hz, 1H) , 7.18(d, J=7Hz, 1H), 7.22(d, J=8Hz, 1H), 7.37(t, J=7Hz, 2H), 7.45(t, J=7Hz, 1H), 7.70(d, J=7Hz, 2H). In a manner similar to that described in Example 94, the compound of Example 95 was synthesized. Example 95 Synthesis of 2-[3-[[N-3-Benzenesulfonamidopropyl-N-(benzoxazol-2-yl)]aminomethyl]phenoxy]propionic acid (Figure Removed) 1R NMR (400 MHz, CD3OD) 8 1.43(d, J = 7 Hz, 3H) , 1.69(quintet, J = 7 Hz, 2H), 2.78(t, J = 7 Hz, 2H), 3.40(t, J= 7 Hz, 2H), 4.54(q, J = 7 Hz, 1H), 4.57(s, 2H), 6.70-6.75(m, 3H), 6.95(t, J = 7 Hz, 1H), 7.08(t, J = 7 Hz, 1H), 7.11(t, J = 8 Hz, 1H) , 7.18(d, J = 7 Hz, 1H) , 7.22(d, J = 8 Hz, 1H), 7.37(t, J = 7 Hz, 2H), 7.45(t, J = 7 Hz, 1H), 7.70(d, J = 7 Hz, 2H). Production Example 41 Synthesis of 3- [ [A/-2-Iodophenylaminocarbonyl-A7-3- ( 4-methoxyphenoxy)propyl]aminomethyl]phenol A (Figure Removed) 2-Iodophenylisochiocyanate (2.5 mg, 9.58 mmol) was dissolved in tetrahydrofuran (50 ml), and 3-[N-[3-(4-methoxyphenoxy)propyl]aminomethyl]phenol (2.75 g, 9.57 mmol) was added thereto. The mixture was stirred at room temperature. Two hours later, the reaction solution was concentrated under reduced pressure, added by ethyl acetate (200 ml), washed with water and brine sequentially, and dried over anhydrous magnesium sulfate. The reaction solution was concentrated under reduced pressure and then purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1), whereby the target compound was obtained as a yellow oil (4.27 g, 7.79 mmol, 81.3%). 'H-NMR (400MHz, CDC13) 5 2.25(quintet, J = 7 Hz, 2H), 3.74(s, 3H), 3.97-4.05(m, 4H), 5.10(s, 2H), 6.77(s, 5H), 6.91-6.95(m, 3H), 7.22-7.26(m, 1H), 7.31(t, J= 8 Hz, 1H) , 7.53(d, J= 8 Hz, 1H), 7.78(d, J = 8 Hz, 1H). Production Example 42 Synthesis of 3-[[N-(Benzothiazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenol 3-[[N-2-iodophenylaminocarbonyl-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenol (4.27 g, 7.79 mmol) was added under an argon atmosphere and dissolved in 1,4-dioxane (100 ml), and thereto were added tris(dibenzylideneacetone)dipalladium (400 mg, 0.390 mmol), 1,1'-bis(phenylphosphino)ferrocene (215 mg, 0.390 mmol). The mixture was stirred at 80°C, filtered with cerite, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 2/1), whereby the target compound was obtained as a pale brown powder (2.31 g, 5.49 mmol, 70.6%). :H-NMR (400MHz, CDC13) 5 2.08 (quintet, J= 1 Hz, 2H) , 3.53(t, J = 7 Hz, 2H), 3.76(s. 3H), 3.91(t, J = 6 Hz, 2H) , 4.67(s, 2H), 6.96-6.83(m, 7H) , 7.04(t, J= 8 Hz, 1H), 7.15(t, J= 8 Hz, 1H), 7.23(t, J = 8 Hz, 1H), 7.46(d, J = 8 Hz, 2H). Production Example 43 Synthesis of Ethyl 3- [ [3-A7- (benzothiazol-2-yl) -N-3- (4-methoxyphenoxy)propyl]aminomethyl] phenoxy) propionate (Figure Removed) 3- [ [A/- (Benzothiazol-2-yl) -A/-3- (4- methoxyphenoxy)propyl]aminomethyl]phenol(1.33 g, 31.6 mmol)was dissolved in toluene (10 ml) at an argon atmosphere, and thereto were added ethyl lactate (486 mg, 4.11 mmol) and triphenylphosphine (1.07 mg, 4.11 mmol). Te mixture was cooled at 0°C and diethylazodicarboxylate (40% in toluene) was dropwise added thereto slowly. Thereafter, the miture was gradually warmed to room temperature and stirred for 12 hours. The reaction solution was dissolved in ethyl acetate (100 ml), washed with water and brine, and then dried over anhydrous magnesium sulfate. The resultant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 4/1), whereby the target compound was obtained as a yellow amorphous (1.17 g, 2.25 mmol, 71.1%). 'H-NMR (400MHz, CDC13) 6 1.57(d, J = 7 Hz, 3H) , 2. 16 (quintet, J = 7 Hz, 2H), 3.70(t, J= 7 Hz, 2H), 3.76(s, 3H), 3.96(t, J = 6 Hz, 2H), 4.07-4.17(m, 2H), 4.68(q, J = 7 Hz, 2H) , 4.74(s, 2H), 6.75(dd, J = 9, 2 Hz, 1H), 6.81-6.83(m, 5H), 6.89(d, J= 7 Hz, 1H), 7.05(dt, J= 7, 1 Hz, 1H), 7.21(t, J = 8 Hz, 1H), 7.28(dt, J = 7, 1 Hz, 1H), 7.55(dd, J= 7, 1 Hz, 2H). Example 96 Synthesis of 3-[[3-N-(Benzothiazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy) propionic Acid (Figure Removed) Ethyl 3-[[3-N- (benzothiazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionate (1.17 mg, 2.25 mmol) was dissolved in ethanol (2 ml), and a 4N-sodium hydroxide solution (1.13 ml) was dropwise added thereto. The solution was stirred at room temperature for 1 hour. Thereafter, the solution was acidified with 2M-hydrochloric acid (5 ml) and extracted by adding chloroform (20 ml) to obtain an organic layer. The extracted organic layer was washed with water and brine sequentially, and then dried over anhydrous sodium sulfate. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 20/1), whereby the target compound was obtained as a pale brown amorphous (1.00 g, 2.03 mmol, 90.3%). 'H-NMR (400MHz, CDC13) 5 1.53(d, J = 7 Hz, 3H) , 2.04(br, 2H) , 3.61(br, 2H), 3.72(s, 3H), 3.86(br, 2H), 4.56(br, 1H), 4.62(s, 2H), 6.72-6.81(m, 7H) , 7.00(t, J= 8 Hz, 1H), 7.08(br, 1H), 7.24(t, J = 8 Hz, 1H), 7.50(d, J = 8 Hz, 2H). In a manner similar to that described in Example 96, the compounds of Examples 97 through 111 were synthesized. Example 97 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2-phenoxyethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) :H NMR (400 MHz, CD3OD) 6 0.91(t, J = 8 Hz, 3H), 1.75-1.82(m, 2H), 3.77-3.87(m, 2H), 4.11(t, J = 6 Hz, 2H) , 4.38(t, J = 6 Hz, 1H), 4.73(s, 2H), 6.70(d, J = 9 Hz, 1H), 6.74-6.79(m, 4H), 6.95(t, J = 7 Hz, 1H) , 7.08-7.13 (m, 4H) , 7.16(t, J = 7 Hz, 1H), 7.39(d, J = 8 Hz, 1H), 7.50(d, J = 8 Hz, 1H). Example 98 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2-(4- fluorophenoxy)ethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) H NMR (400 MHz, CD3OD) 5 0.92(t, J = 7 Hz, 3H) , 1.76-1.82 (m, 2H), 3.84(t, J = 5 Hz, 2H), 4.10(t, J = 5 Hz, 2H), 4.36(t, J= 6 Hz, 1H), 4.74(s, 2H), 6.70-6.87(m, 7H), 6.96(td, J = 8, 2 Hz, 1H), 7.10(t, J = 8 Hz, 1H), 7.17(td, J = 8, 2 Hz, 1H), 7.39(d, J = 8 Hz, 1H), 7.52(d, J = 8 Hz, 1H). Example 99 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2-(4-chlorophenoxy)ethyl]aminomethyl]phenoxy]butyric acid XH NMR (400 MHz, CD3OD) 8 0.92(t, J = 7 Hz, 3H) , 1.76-1. 82 (m, 2H), 3.85(t, J = 6 Hz, 2H), 4.12(t, J = 5 Hz, 2H), 4.33(t, J = 6 Hz, 1H), 4.74(s, 2H), 6.70-6.79(m, 5H), 6.95(td, J = 8, 2 Hz, 1H), 7.08-7.12(m, 3H), 7.18(td, J = 8, 2 Hz, 1H), 7.39(d, J = 8 Hz, 1H), 7.52{d, J = 8 Hz, 1H). Example 100 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2-(4-methoxyphenoxy)ethyl]aminomethyl]phenoxy]butyric acid (Figure Removed) MeO XH NMR (400 MHz, CD3OD) 8 1.01(t, J = 7 Hz, 3H), 1.85-1.90(m, 2H), 3.70(s, 3H) , 3.91(t, J = 5 Hz, 2H), 4.17(t, J = 5 Hz, 2H), 4.42(t, J = 6 Hz, 1H) , 4.84(s, 2H), 6.79-6.81(m, 5H), 6.86-6.88(m, 2H), 7.06(td, J = 8, 2 Hz, 1H), 7.19(t, J = 8Hz, 1H), 7.26(td, J = 8, 2 Hz, 1H), 7.48(d, J = 8 Hz, 1H), 7.61(d, J = 7 Hz, 1H). Example 101 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2- phenoxyethyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR (400 MHz, CD3OD) 8 1.49(d, J = 7Hz, 3H) , 3.93(t, J = 5Hz, 2H) , 4.21(t, J = 5Hz, 2H) , 4.62(q, J = 6Hz, 1H), 4.83(s, 2H), 6.79(d, J = 9Hz, 1H), 6.84-6.90(m, 5H), 7.05(td, J = 8, 2 Hz, 1H), 7.17-7.21(m, 3H) , 7.26(td, J = 8, 2 Hz, 1H) , 7.48(d, J = 8 Hz, 1H), 7.60(d, J = 8 Hz, 1H). Example 102 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2-(4- fluorophenoxy)ethyl]aminomethyl]phenoxy]propionic acid 1tt NMR (400 MHz, CDC13) 6 1.41(d, J = 6 Hz, 3H), 3.81-3.90(m, 2H), 4.07-4.16(m, 2H), 4.56(q, J = 7 Hz, 1H) , 4.72(s, 2H) , 6.15(brd, 1H), 6.70-6.75(m, 2H), 6.82-6.84(m, 2H), 6.89(t, J = 8 Hz, 2H) , 7.02(t, J = 8Hz, 1H) , 7.09(t, J = 8 Hz, 1H), 7.24(t, J = 7 Hz, 2H), 7.49(d, J = 8 Hz, 1H), 7.51(d, J = 8 Hz, 1H) . Example 103 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2-(4- chlorophenoxy)ethyl]aminomethyl]phenoxy]propionic acid (Figure Removed) *H NMR (400 MHz, CD3OD) 5 1.50(d, J = 7 Hz, 3H) , 3.94(t, J = 5 Hz, 2H) , 4.21(t, J = 5 Hz, 2H) , 4.55(q, J = 7 Hz, 1H) , 4.82(s, 2H), 6.79(d, J = 8 Hz, 1H), 6.83-6.87(m, 4H), 7.06(t, J = 8 Hz, 1H), 7.18(t, J = 8 Hz, 3H), 7.27(t, J = 8 Hz, 1H), 7.48(d, J = 8 Hz, 1H), 7.61(d, J = 8 Hz, 1H). Example 104 Synthesis of 2-[3-[[N-(Benzothiazol-2-yl)-N-2-(4-methoxyphenoxy)ethyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR (400 MHz, CD3OD) 5 1.49(d, J = 7Hz, 3H), 3.71(s, 3H) , 3.92(t, J = 5 Hz, 2H), 4.19(t, J = 5 Hz, 2H), 4.51(q, J = 7 Hz, 1H), 4.84(s, 2H), 6.77-6-88(m, 7H), 7.06(td, J =8, 2 Hz, 1H), 7.18(t, J = 8Hz, 1H), 7.27(td, J = 8, 2 Hz, 1H) , 7.48(d, J = 8 Hz, 1H), 7.61(d, J = 8 Hz, 1H). Example 105 Synthesis of 2- [ 3- [ [N-(Benzothiazol-2-yl)-N-3-phenoxypropyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR (400 MHz, CD3OD) 5 1.02(t, J = 7 Hz, 3H), 1.85-1.96(m, 2H) , 2.12 (quintet, J = 7 Hz, 2H) , 3.69(t, J = 7 Hz, 2H) , 3.97(t, J = 6 Hz, 2H), 4.49(t, J = 6 Hz, 1H) , 4.74(s, 2H) , 6.80(d, J = 8 Hz, 1H), 6.86-6.91(m, 4H), 7.04(td, J = 8, 2 Hz, 1H), 7.18-7.27(m, 5H), 7.46(d, J = 8 Hz, 1H), 7.58(d, J = 8 Hz, 1H) . Example 106 Synthesis of 2-[3-[[(N-Benzothiazol-2-yl)-N-3-(4- fluorophenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) 1H NMR (400 MHz, CD3OD) 8 1.03(t, J = 7Hz, 3H), 1.85-1.96(m, 2H), 2.13 (quintet, J = 6 Hz, 2H) , 3.72(t, J = 7 Hz, 2H) , 3.97(t, J = 6 Hz, 2H), 4.51(t, J = 6 Hz, 1H) , 4.77(s, 2H) , 6.80-6.97(m, 7H), 7.05(t, J = 8 Hz, 1H), 7.22(t, J = 8 Hz, 1H), 7.26(td, J = 8, 2 Hz, 1H) , 7.46(d, J = 8 Hz, 1H) , 7.59(d, J = 8 Hz, 1H). Example 107 Synthesis of 2-[3-[[(N-Benzothiazol-2-yl)-N-3-(4-chlorophenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) :H NMR (400 MHz, CD3OD) 8 0.94(t, J = 7 Hz, 3H) , 1.78-1. 83 (m, 2H) , 2.05 (quintet, J = 7 Hz, 2H) , 3.62(t, J = 7 Hz, 2H) , 3.89(t, J = 6 Hz, 2H), 4.36(t, J = 6 Hz, 1H) , 4.67(s, 2H) , 6.70-6.79(m, 5H), 6.96(td, J = 8, 2 Hz, 1H), 7.10-7.13(m, 3H), 7.16(td, J = 8, 2 Hz, 1H), 7.36(d, J = 8 Hz, 1H) , 7.50(d, J = 8 Hz, 1H). Example 108 Synthesis of 2-[3-[[(N-Benzothiazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) lti NMR (400 MHz, CD3OD) 6 1.02(t, J = 7 Hz, 3H) , 1.87-1. 93 (m, 2H), 2.11(quintet, J = 6 Hz, 2H), 3.68-3.71(m, 5H), 3.94(t, J = 6 Hz, 2H), 4.47(t, J = 6 Hz, 1H), 4.75(s, 2H), 6.78-6.82(m, 5H), 6.87(m/ 2H), 7.04(t, J = 8 Hz, 1H), 7.21(t, J = 8 Hz, 1H), 7.26(td, J = 8, 2 Hz, 1H), 7.46(d, J = 8 Hz, 1H) , 7.59(d, J = 8 Hz, 1H). Example 109 Synthesis of 2-[3-[[(N-Benzothiazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxy]propionic acid 1ti NMR (400 MHz, CD3OD) 8 1.42(d, J = 7 Hz, 3H), 2.05(quintet, J = 7 Hz, 2H), 3.62(t, J = 7 Hz, 2H), 3.90(t, J = 6 Hz, 2H), 4.56(q, J = 7 Hz, 1H) , 4.66(s, 2H) , 6.71(d, J = 8 Hz, 1H) , 6.77-6.81 (m, 5H) , 6.95(t, J = 8 Hz, 1H) , 7 . 09-7 . 18 (m, 4H) , 7.36(d, J = 8 Hz, 1H), 7.50(d, J = 8 Hz, 1H) . Example 110 Synthesis of 2-[3-[[(N-Benzothiazol-2-yl)-N-3-(4-fluorophenoxy)propyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR (400 MHz, CDC13) 5 1.37(d, J = 5 Hz, 3H) , 2.07(quintet, J = 6 Hz, 2H), 3.62(t, J = 7 Hz, 2H), 3.87(t, J = 6 Hz, 2H), 4.52(q, J = 7 Hz, 1H), 4.62(s, 2H), 6.69-6.80(m, 5H), 6.91(t, J = 8 Hz, 2H) , 7.00(t, J = 8 Hz, 1H), 7.06(t, J = 8 Hz, 1H), 7.22(t, J = 8 Hz, 1H), 7.48(t, J = 8 Hz, 2H). Example 111 Synthesis of 2-[3-[[(N-Benzothiazol-2-yl)-N-3-(4-chlorophenoxy)propyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR (400 MHz, CD3OD) 8 1.51(d, J = 7 Hz, 3H), 2.12(quintet, J = 7 Hz, 2H), 3.70(t, J = 7 Hz, 2H), 3.96(t, J = 6 Hz, 2H), 4.62(q, J = 7 Hz, 1H), 4.74(s, 2H), 6.79-6.87(m, 5H), 7.04(t, J = 7 Hz, 1H), 7.17-7.22(m, 3H) , 7.25(td, J = 8, 2 Hz, 1H), 7.45(d, J = 8 Hz, 1H), 7.58(d, J = 8 Hz, 1H). Production Example 44 Synthesis of Ethyl 2-[3-[ [IV-2-Nitrophenylaminocarbonyl-W-3-(4-methoxyphenoxy)propyl] aminomethyl]phenoxy]propionate (Figure Removed) Ethyl 2-[3-[[N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionate (754 mg, 1.94 mmol) was dissolved in tetrahydrofuran (3.0 ml), and 2-nitrophenylisocyanate (290 mg, 1.76 mmol) was added thereto. The mixture was stirred for 5 hours, thereafter added to water, and extracted with ethyl acetate to obtain an organic layer. The extracted organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 4/1), whereby the target compound was obtained (1.0 g, 96%). XH NMR(400MHz, CDC13) 5 1.21 (t, J = 7 Hz, 3H) , 1.60 (d, J = 7 Hz, 3H), 2.14 (quintet, J = 1 Hz, 2H), 3.64 (t, J= 7 Hz, 2H), 3.76 (s, 3H), 3.99 (t, J= 7 Hz, 2H) , 4.18 (q, J= 7 Hz, 2H), 4.63 (s, 2H), 4.74 (q, J= 7 Hz, 1H), 6.76-6.93 (m, 7H), 7.04 (t, J= 8 Hz, 1H), 7.25 (t, J= 8 Hz, 1H), 7.59 (t, J= 1 Hz, 1H) , 8.17 (d, J = 8 Hz, 1H) , 8.68 (d, J = 9 Hz, 1H) , 10.21 (s, 1H) Production Example 45 Synthesis of Ethyl 2- [3- [ [A7-2-aminophenylaminocarbonyl-A7-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy] propionate (Figure Removed) Ethyl 2- [3- [ [A7-2-nitrophenylaminocarbonyl-W-3- (4-methoxyphenoxy)propyl]aminomethyl]phenoxy]propionate (1.0 g, 1.81 mmol) was dissolved in ethyl acetate (3.0 ml), then added to palladium carbon (5% in catalytic proportion), and stirred at room temperature for 3 hours under a hydrogen atmosphere. After palladium was removed using cerite, the resultant mixture was concentrated under reduced pressure and purified by silica gel column chromatography (chloroform/methanol = 30/1), whereby the target compound was obtained (892 mg, 99%). XH NMR(400MHz, CDC13) 5 1.22 (t, J= 7 Hz, 3H) , 1.61 (d, J = 7 Hz, 3H), 2.04 (quintet, J = 6 Hz, 2H), 3.60 (t, J = 7 Hz, 2H), 3.76 (s, 3H), 3.80 (br s., 2H) , 4.02 (t, J= 6 Hz, 2H) , 4.17-4.22 (m, 2H) , 4.55 (d, J = 16 Hz, 1H), 4.75 (d, J = 16 Hz, 1H), 6.65-6.97 (m, 12H), 7.26 (t, J= 8 Hz, 1H) Production Example 46 Synthesis of Ethyl 2-[3-[[N- (benzimidazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy] propionate (Figure Removed) Ethyl 2-[3-[ [A7-2-aminophenylaminocarbonyl N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy] propionate (108 mg, 0.20 mmol) was dissolved in toluene (3.0 ml), and phosphorus oxychloride (0.02 ml, 0.20 mmol) was added thereto at room temperature. The mixture was stirred for 2 hours, then added to saturated aqueous sodium hydrogencarbonate, and thereafter extracted with ethyl acetate to obtain an organic layer. The extracted organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by silica gel column chromatography (chloroform/methanol = 50/1), whereby the target compound was obtained (50.5 m g, 48%). 1H NMR(400MHz, CDC13) 6 1.16 (t, J = 7 Hz, 3H) , 1.58 (d, J = 7 Hz, 3H) , 1.97-2.00 (m, 2H) , 3.62-3.65 (m, 2H) , 3.78 (s, 3H) , 4.03-4.13 (m, 2H) , 4.69 (q, J= 7 Hz, 2H) , 4.72 (d, J = 16 Hz, 1H), 4.82 (d, J = 16 Hz, 1H) , 6.76 (dd, J = 16 , 3 Hz, 1H), 6.84-6.95 (m, 10H), 7.21 (t, J= 8 Hz, 1H) Production Example 47 Synthesis of Ethyl 2- [3- [ [A/- (l-methylbenzimidazol-2-yl) -A7-3- (4-methoxyphenoxy)propyl] aminomethyl]phenoxy] propionate (Figure Removed) Ethyl 2- [3- [ [N- (benzimidazol-2-yl) -A7-3- (4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionate (49.0 mg, 0.09 mmol) was dissolved in dimethylformamide (3.0 ml), then added to 55%-sodium hydride (4.25 mg, 0.097 mmol) at 0°C, and stirred for 20 minutes. The mixture was stirred at room temperature for 2 hours after methyl iodide (0.007 ml, 0.12 mmol) was dropwise added thereto at 0°C. The resultant mixture was added to water and extercted with ethyl acetate to obtain an organic layer. The extracted organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulant substance was purified by silica gel column chromatography (n-hexane/ethyl acetate = 1/1), whereby the target compound was obtained (40.7 mg, 81%). XH NMR(400MHz, CDC13) 5 1.21 (t, J = 7 Hz, 3H), 1.58 (d, J = 7 Hz, 3H), 2.02 (quintet, J = 6 Hz, 2H), 3.44 (t, J= 1 Hz, 2H) , 3.63 (s, 3H) , 3.74 (s, 3H) , 3.88 (t, J = 6 Hz, 2H) , 4.13-4.18 (m, 2H) , 4.45 (s, 2H) , 4.68 (q, J = 7 Hz, 1H) , 6.68-6.77 (m, 5H) , 6.91 (s, 1H) , 6.96 (d, J = 8 Hz, 1H) , 7.14-7.21 (m, 4H), 7.58-7.61 (m, 1H) Example 112 Synthesis of 2-[3-[[N- (l-Methylbenzimidazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl] phenoxy] propionic acid (Figure Removed) Ethyl 2-[3-[[W- (l-methylbenzimidazol-2-yl)-A/-3-(4-methoxyphenoxy)propyl]aminomethyl] phenoxy] propionate (39.0 mg, 0.075 mmol) was dissolved in ethanol (3.0 ml), and 2 mol/L sodium hydroxide (0.075 ml, 0.15 mmol) was dropwise added thereto. The mixture was stirred for 5 hours and concentrated under reduced pressure. Thereaftre, the resultant mixture was added to saturated ammonium chloride and then extracted with chloroform, to obtain an organic layer. The extracted organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant substance was purified by by silica gel column chromatography (chloroform/methanol = 30/1), whereby the target compound was obtained (29.3 mg, 79%). 1H NMR(400MHz, CD3OD) 5 1.38 (d, J= 7 Hz, 3H), 1.89 (quintet, J= 7 Hz, 2H), 3.37 (t, J= 6 Hz, 2H), 3.55 (s, 3H), 3.57 (s, (Figure Removed) 3H), 3.78 (t, J= 6 Hz, 2H), 4.35 (s, 2H) , 4.39 (q, J= 7 Hz, 1H), 6.55-6.61 (m, 4H) , 6.68 (dd, J= 8, 2 Hz, 1H), 6.75 (d, J = 8 Hz, 1H), 6.80 (s, 1H), 7.02-7.07 (m, 3H), 7.14-7.17 (m, 1H), 7.29-7.32 (m, 1H) In a manner similar to that described in Example 112, the compounds of Examples 113 through 124 were synthesized. Example 113 Synthesis of 2-[3-[[N-(Benzimidazol-2-yl)-N-3-phenoxypropyl]aminomethyl]phenoxy]butyric acid (Figure Removed) lti NMR(400MHz, CD3OD) 5 0.92 (t, J = 7 Hz, 3H), 1.73-1.85 (m, 2H), 2.02 (quintet, J = 6 Hz, 2H), 3.56-3.60 (m, 2H), 3.91 (t, J = 6 Hz, 2H), 4.21-4.24 (m, 1H), 4.61 (s, 2H), 6.69-6.80 (m, 6H), 6.93-6.97 (m, 2H), 7.06-7.16 (m, 5H). Exampele 114 Synthesis of 2-[3-[[N-(Benzimidazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxy]propionic acid (Figure Removed) 1R NMR(400MHz, CD3OD) 5 1.38 (d, J = 7 Hz, 3H), 1.99 (quintet, J = 6 Hz, 2H), 3.55 (t, J = 7 Hz, 2H), 3.87 (t, J = 6 Hz, 2H), 4.40 (t, J = 7 Hz, 1H) , 4.58 (s, 2H) , 6.67-6.76 (m, 6H) , 6.93-6.95 (m, 2H), 7.05-7.14 (m, 5H). Example 115 Synthesis of 2-[3-[[N-(1-Methanesulfonylbenzimidazol-2-yl)-N- 3-phenoxypropyl]aminomethyl]phenoxy]butyric acid (Figure Removed) lti NMR(400MHz, CD3C13) 6 1.26 (d, J = 7 Hz, 3H) , 1.83 (br.s, 2H), 2.02-2.06 (m, 2H) , 2.57 (s, 3H) , 3.54 (br.s, 2H) , 3.95 (t, J = 6 Hz, 2H), 4.40 (br. s, 1H) , 4.52 (d, J = 15 Hz, 1H), 4.59 (d, J = 15 Hz, 1H), 6.74-6.87 (m, 5H), 7.08-7.29 (m, 6H), 7.46 (d, J = 8 Hz, 1H), 7.73' (d, J = 8 Hz, 1H) . Example 116 Synthesis of 2-[3-[[N-(1-Methanesulfonylbenzimidazol-2-yl)-N- 3-phenoxypropyl]aminomethyl]phenoxy]propionic acid (Figure Removed) *H NMR(400MHz, CD3C13) 5 1.43 (br.s, 3H) , 2.06 (br.s, 2H) , 3.55 (t, J = 7 Hz, 2H), 3.96 (t, J = 7 Hz, 2H), 3.96 (t, J = 6 Hz, 2H) , 4.51-4.61 (m, 3H), 6.75-6.88 (m, 6H), 7.07-7.29 (m, 5H), 7.47 (d, J = 8 Hz, 1H), 7.73 (d, J = 8 Hz, 1H). Example 117 Synthesis of 2-[3-[[N-(Benzimidazol-2-yl)-N-3-(4- fluorophenoxy)propyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR(400MHz, CD3OD) 5 1.50 (d, J = 7 Hz, 3H), 2.16 (quintet, J = 6 Hz, 2H) , 3.73-3.77 (m, 2H) , 3.87 (t, J = 6 Hz, 2H) , 4.01 (t, J = 6 Hz, 2H), 4.52 (q, J = 6 Hz, 2H), 4.76 (s, 2H), 6.82-6.85 (m, 5H), 6.90-7.00 (m, 2H), 7.19-7.32 (m, 5H) . Example 118 Synthesis of 2-[3-[[N-(Benzimidazol-2-yl)-N-3-(4- fluorophenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR(400MHz, CD3OD) 5 1.03 (t, J = 7 Hz, 3H), 1.84-1.92 (m, 2H), 2.16 (quintet, J = 6 Hz, 2H), 3.73-3.77 (m, 2H), 4.01 (t, J = 6 Hz, 2H), 4.33-4.36 (m, 1H), 4.76 (s, 2H) , 6.81-6.95 (m, 7H), 7.19-7.25 (m, 3H), 7.30-7.33 (m, 2H). Example 119 Synthesis of 2-[3-[[N-(Benzimidazol-2-yl)-N-3-(4- methoxyphenoxy)propyl]aminomethyl]phenoxy]propionic acid (Figure Removed) cH NMR(400MHz, CD3OD) 6 1.39 (d, J = 7 Hz, 3H), 1.99 (quintet, J = 6 Hz, 2H), 3.54-3.57 (m, 2H) , 3.60 (s, 3H) , 3.84 (t, J = 6 Hz, 2H), 4.39 (q, J = 7 Hz, 1H), 4.60 (s, 2H) , 6.55-6.70 (m, 7H), 6.93-6.95 (m, 2H), 7.07 (t, J = 8 Hz, 1H), 7.09-7.14 (m, 2H) . Example 120 Synthesis of 2-[3-[[N-(Benzimidazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR(400MHz, CD3OD) 5 1.03 (t, J = 7 Hz, 3H), 1.85-1.91 (m, 2H) , 2.13 (quintet, J = 7 Hz, 2H), 3.70 (s, 3H), 3.72-3.75 (m, 2H), 3.98 (t, J = 5 Hz, 2H), 4.32 (t, J = 5 Hz, 1H), 4.74 (s, 2H), 6.77 (d, J = 1 Hz, 5H), 6.82 (t, J = 8 Hz, 2H), 7.17 (dd, J = 164 6, 3 Hz, 2H), 7.21 (t, J = 8 Hz, 1H), 7.28 (dd, J = 6, 3 Hz, 2H) . Example 121 Synthesis of 2-[3-[[N-(l-Methylbenzimidazol-2-yl)-N-3- phenoxypropyl]aminomethyl]phenoxy]propionic acid (Figure Removed) lti NMR(400MHz, CD3OD) 5 1.37 (t, J = 7 Hz, 3H), 1.90 (quintet, J = 6 Hz, 2H), 3.36 (t, J = 7 Hz, 2H), 3.53 (s, 3H), 3.81 (t, J = 6 Hz, 2H) , 4.33 (s, 2H), 4.39 (q, J = 7 Hz, 2H) , 6.62-6.79 (m, 6H), 7.00-7.06 (m, 5H), 7.13-7.15 (m, 1H), 7.29-7.32 (m, 1H) . Example 122 Synthesis of 2-[3-[[N-(l-Methylbenzimidazol-2-yl)-N-3-phenoxypropyl]aminomethyl]phenoxy]butyric acid (Figure Removed) XH NMR(400MHz, CD3OD) 5 0.91 (t, J = 7 Hz, 3H), 1.76-1.94 (m, 4H), 3.38 (t, J = 7 Hz, 2H), 3.55 (s, 3H), 3.83 (t, J = 6 Hz, 2H), 4.36 (s, 2H), 6.63-6.79 (m, 6H) , 7.01-7.06 (m, 5H) , 7.15-7.16 (m, 1H), 7.30-7.32 (m, 1H). Example 123 Synthesis of 2-[3-[[N-(l-Methylbenzimidazol-2-yl)-N-3-(4-fluorophenoxy)propyl]aminomethyl]phenoxy]propionic acid (Figure Removed) XH NMR(400MHz, CD3OD) 5 1.39 (d, J = 6 Hz, 3H) , 1.93 ( quintet, J 7 Hz, 2H), 3.40 (t, J = 7 Hz, 2H), 3.59 (s, 3H) , 3.83 (t, J = 6 Hz, 2H), 4.36-4.44 (m, 3H), 6.59-6.69 (m, 2H), 6.72-6.81 (m, 2H) , 7.04-7.09 (m, 6H) , 7.18-7.20 (m, 1H) , 7.29-7.32 (m, 1H). Example 124 Synthesis of 2-[3-[[N-(l-Methylbenzimidazol-2-yl)-N-3-(4-fluorophenoxy)propyl]aminomethyl]phenoxy]butyric acid (Figure Removed) 1H NMR(400MHz, CD3OD) 5 0.93 (t, J = 7 Hz, 3H), 1.73-1.85 (m, 2H), 1.94 (quintet, J = 6 Hz, 2H) , 3.41 (t, J = 7 Hz, 2H) , 3.60 (s, 3H), 3.83 (t, J = 6 Hz, 2H), 4.22-4.25 (m, 1H), 4.39 (s, 2H), 6.61-6.81 (m, 7H), 7.04-7.09 (m, 3H), 7.18-7.32 (m, 2H) . Also, in a manner similar to that described in Example 1, the compounds shown in Tables 1 to 4 below have been synthesized. (Table Removed) [Table 5] (Table Removed) [Table 6] [Table 7] [ Table 8] (Figure Removed) Test Example 1 PPAR activating effects of the compounds of the present invention represented by formula (1) and comparative compounds disclosed in WO 02/46176 (hereinafter referred to as compounds A, B, and C) were determined through the following method (Proc. Natl. Acad. Sci., 92, pp. 7297-7301, 1995; Journal of Lipid Research, 40, pp. 2099-2110, 1999; and Proc. Natl. Acad. Sci, 98, pp. 5306-5311, 2001). Compound A Measurement methods Transfection assay COS-7 cells, which is African green monkey kidney cell line, were used for all transfection assays. Cells were cultured in DMEM medium supplemented with 10% fetal bovine serum, glutamic acid, and an antibiotic under humidified 5% C02 atmosphere. Cells were transfected by lipofectamine reagent with a mixture containing expression plasmid, firefly luciferase reporter plasmid. And a p-galactosidase expression plasmid used as an internal control for transfection efficiency. The each expression vector contained Gal4 DNA-binding domain, which is yeast transcription factor and human PPARoc(166-467aa), y(182-505aa) or 8(137-441aa) ligand binding domain. Transiently transfected cells were incubated with DMEM with 0.2% FCS with or without compound. And after 16 hours, luciferase activity and p-galactosidase activity of cell lysate were measured. Each compound was dissolved in and diluted with dimethyl sulfoxide (DMSO), and the DMSO concentration of the DMEM medium (containing 0.2% serum) was adjusted to 0.1% upon treatment of cells. The positive control compounds employed are WY 14643, troglitazone (Journal of Medicinal Chemistry, 43, pp. 527-550, 2000), and GW 501516 (Proc. Natl. Acad. Sci., 98, pp. 5306-5311, 2001) for PPARoc, PPARy, and PPAR6, respectively. Table 9 shows agonist activity (to hPPARa, hPPARy, hPPAR5) of the compounds of the present invention and the comparative Compound. Table 9 (Table Removed) The hPPARoc selectivities of compounds A and B were found to be low, and specifically, their levels are only less than 10-fold at EC50 values. In addition, compound C was found to exhibit no activation of any hPPAR isoform. In contrast, the compounds of the present invention exhibited excellent hPPARa selectivity, clearly revealing that the compounds of the present invention have high hPPARa selectivity as compared with compounds A, B, and C disclosed in WO 02/46176. Figs. 1 to 5 show activation factors, with respect to each hPPAR isoform, of the compounds of the present invention (Examples 1 and 2) and the comparative compounds (compounds A, B, and C) as determined at corresponding EC50 values in activation of hPPARa and at concentrations 10 times those of ECso values. The activation factor is defined as a ratio of activity of test compound to that of control, which contains only the solvent (DMSO) and no test compound. As is clear from these Figures, the compounds of Examples 1 and 2 exhibited substantially no activation of hPPARy and hPPAR8 even at the 10-fold concentration of EC5o value in activation of hPPARa, while compounds A and B strongly activate hPPARy and hPPARS at the 10-fold concentration of EC50 value in activation of hPPARa. Compound C was found to have activated no hPPAR isoform. The results indicate that the compounds of the present invention can be used as excellent hPPARoc-selective activators. We claim 1. A phenoxy carboxylic acid compound represented by the following formula (1): (Formula Removed) (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3aand R3bor R4aand R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)1 (1 is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or NH; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof. 2. The compound as claimed in claim 1, wherein X represents an oxygen atom, Y represents an oxygen atom, and Z represents CH. 3. The compound as claimed in Claim 1, wherein the compound is selected from the group consisting of: 2—[3—[[N—(Benzoxazol—2—yl)—N—3—(4— fluorophenoxy) propyl] aminomethyl] phenoxy] butyric acid, or a salt thereof, 2—[3— [[N— (Benzoxazol—2—yl) —N—2— (4— chiorophenoxy) ethyl] aminomethyl]phenoxy]butyric acid, or a salt thereof, 2— [3— [ [ N— (Benzoxazol—2—yl) —N—2— (4— fluorophenoxy) ethyl] aminomethyl] phenoxy] butyric acid, or a salt thereof, 2— [3— [ [ N— (Benzoxazol—2—yl) —N—3— phenoxypropyl] aminomethyl] phenoxy] propionic acid, or a salt thereof, 2— [3— [ [ N— (Benzoxazol—2—yl) —N—3— phenoxypropyl] aminomethyl]phenoxy] acetic acid, or a salt thereof, 2— [3— [ [ N— (Benzoxazol—2—yl) —N—3— phenoxypropyl] aminomethyl] phenoxy] butyric acid, or a salt thereof, 2— [3— [[N— (Benzoxazol—2—yl) —N—3— (4— methoxyphenoxy)propyl] aminomethyl] phenoxy] butyric acid, or a salt thereof, 2— [3— [ [ N— (Benzoxazol—2—yl) —N—3— (4— methoxyphenoxy)propyl]aminomethyl] phenoxy] propionic acid, or a salt thereof. 4. A pharmaceutical composition comprising a compound or a salt thereof as claimed in any one of claims 1 through 3 and a pharmacologically acceptable carrier.

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