Title of Invention

AN ECOFRIENDLY PROCESS FOR ACYLATION OF ALKYLATED BENZENE DERIVATIVES PREFERABLY AT PARA POSITION

Abstract The present invention relates to an ecofriendly process for acylation of alkylated benzene derivatives preferably at para position, an improved zeolite based catalytic process for the preparation of acylated aromatic ethers namely p-isobutylacetopenone.
Full Text AN ECOFRIENDLY PROCESS FOR ACYLATION OF ALKYLATED BENZENE DERIVATIVES PREFERABLY AT PARA POSITION Field of the Invention
The present invention relates to an ecofriendly process for acylation of alkylated benzene derivatives preferably at para position. More particularly, the present invention relates to zeolite catalysed acylation of isobutylbenzene for the preparation of acylated aromatic compound, namely p-isobutylacetophenone. Background and Prior Art Description
Acylated aromatic compound is chiefly used in pharmaceutical industries. Analgesics (painkillers) are a very well known group of drugs that include asprerine. acetaminophen [Tylenol] and ibuprofen [Motrin, Advil and Medipren], In addition of their analgesic properties, ibuprofen and asprerine are members of non-steroidal anti-inflammatory group of drugs and are thus used to reduce swelling and inflammation Ibuprofen was introduced as a carboxylic acid in 1969, to help provide relief of rheumatoid arthritis. It is believed to be gentler on stomach than aspirin. It metabolites rapidly by the body, usually leaving the body via urination within 24 hours of intake. Ibuprofen is a main component for Advil®, Bayer®, Midol 200®, Motrin IB® and Nuprin®. It is used for the treatment of inflammation and pain caused by rheumatoid arthritis and osteoarrthritis, as well as soft tissue injuries, such as tendentious and bursitis. It is also used for the rapid relief of fever and in mild to moderate pain, such as menstrual cramps.
The industrial process for manufacturing of ibuprofen starts with the acylation of
isobutylbenzene in the presence of conventional Friedel- Crafts catalysts, described as
under.
(A) BOOTS PROCESS
Boots company of England in 1960 developed a process, which is covered in U. S.
Patent No. 3,385,886, having six steps for the production of ibuprofen. It starts with
the acylation of isobutylbenzene in the presence of AlCl3 by using acetic anhydride as
an acylating agent. This multi step process results in large quantity of unwanted waste
chemical as by products. Much of the waste that is generated as a results of many
atoms of the reactant not being incorporated into the desired products (Ibuprofen) but
into by-products. Consequently, process has poor atom economy / atom utilisation.

(Figure Removed) (B) HOESCHT PROCESS.
It is a three-step synthesis of ibuprofen, which is taught in U. S. Patent numbers 4,981,995 and 5,068,448. The Hoescht process also starts with the acylation of isobutylbenzene in the presence of HF by using acetic anhydride as an acylation agent. Compared to Boots process, hoescht process is more eco-friendly, but still the utilisation of hazardous HF for acylation is not safe from handling point of view. Chemical equation:
(Figure Removed)Research efforts to find eco-friendly and safer catalysts, which can replace AlCl3 and
HF, have been directed in the literature and are reviewed here.
Reference is made to the work of E. Nandanan., et al., Indian J. of Chemistry, Vol-
37B, Dec-1998, pp-1221-1227, wherein the preparation of 4-acyl isobutylbenzene using AIC13 and acetyl chloride as an acylating agent is taught. Nandanan et al. used dichloromethane as a solvent. This process has disadvantages of the separation of the catalyst and non- regenerability of the catalyst as well as long reaction time, which is not industrially feasible.
Reference is made to the work of P Andy, et al., J. of Catalysis-192, 215-223 (2000), wherein the Beta zeolite based acylation of isobutylbenzene using acetic anhydride as an acylating agent is taught. This process has disadvantage of low conversion (12 % after 20 hours) and it is not economical to commercialize.
Reference is made to the work of Bich Chichi, et al., J. of Mol. Cat. -42 (1987)-229-235, wherein the Friedel- Craft acylation of aromatic compound (BTX) with earboxylic acid over cation exchanged montmorillonite is taught. This process has disadvantage of poor selectivity towards the para position during the acylation of toluene.
Reference is made to the work of C. De Castro, et al., J. of Mol. Cat.-A:Chemical-134 (1998) 215-222, wherein the acylation of xylene is reported using crotonic acid as an acylating agent in the presence of heteropoly acid and large pore zeolite. This process has disadvantages like, in some case, significant amount of alkylation also occurs leading to generation of undesired by-products and loss of starting compound.
Reference is made to the work of AJ.A. van der Weerdt in his personnel communication wherein the acylation of toluene by isobutyryl chloride in the presence of A1C1;?. This process has disadvantages like more than stochiometric amounts of aluminum chloride is used due to complexation with the ketone, need to have a post reaction effluent treatment process and use of corrosive and irritant AlCb. The major drawback of the above stated process is separation of catalysts after completion of the reaction. This necessitates a long, expensive treatment following hydrolysis, extraction of the organic phase, separation of organic and aqueous phase and even drying of latter. Further, there are problems with aqueous saline effluent which has to be neutralised and which necessities additional operation. The Lewis acid cannot be recycled, as it has been hydrolysed. Reference is made to the work of 1. Akhrem, et al., J. Chem Soc. Comm. P. 257, Vol-3, February 1993. wherein the acylation of benzene is reported by acetyl bromide employing AbBn, as catalyst to p-tertiary butylacetophenone. This
process having disadvantages of waste generation and non-recoverable catalysts as well as requirement of catalysts/reagents which is more than stochiometric amount. Reference is made to the work of Y. Izumi, et al., Chern. Lett.- P. 1987,1992 Vol-10, wherein the acylation of p-xylene by using benzoyl chloride /anhydride is done in the presence of heteropoly acid. This process has disadvantage like, occurrence of simultaneous alkylation in the presence of heteropoly acid, which leads to generation of undesired by-product.
Reference is made to the work of Lapierre R.B, et al., U. S. Pat US 4,899,008, February-1990, wherein the alkylation of benzene and toluene with C2 to C4 alkanes over acidic zeolites is reported. Benzene was reacted with CjHx over H-ZSM-5 at 385-399° C / 6184 kPa for 49 hours to give MePh, 9.92%. This process having disadvantage of operation at very high temperature and pressure. Reference is made to the work of Klein, Alfons, Fiege et al., Ger. Off. D. E. 3839853, 31 May-1990, wherein the alkylation of p-Cresol with cyclohexanol or cyclohexene is done in the presence of acidic zeolite. This process has the disadvantages of operation at high temperature and pressure and low conversions. Reference is made to the work of Davydov, D. V, et al., Izv. Akad. Nauk, SSSR, Ser Khim, 1990 (3), 708-710 (RUSS), wherein LnCl3 (Ln = Pr, Dy, Er, Sm, Yb) and Yb(O^SCI;5) are used as a catalyst for the electrophilic acylation of benzene and toluene with acylchloride and benzaldehyde. This process has disadvantages of multi-step reaction and non-regeneration of the catalyst.
Reference is made to the work of Nakatani, Jinro, kamoto et al., Jp: 09, 278705 wherein benzene is acylated with CH3CH2COOH in the presence of zeolite-beta at 270°C to give about 10% of propiophenone. This process has disadvantages of high temperature and very long reaction time which discourages commercial utilization of the process.
Reference is made to the work of Choudary, et al., (India).Jpn. Kokai Tokkyo Koho Jp 2001278833 A2 10 Oct. 2001, 16 pp, wherein the acylation of isobutylbenzene is done using acetic anhydride as an acylating agent in the presence of nanocrystalline zeolite. This process has the disadvantages of utilizing nanosized materials, which makes the whole process more costly. Wt. % conversion of isobutylbenzene was only 30 wt. %.
Reference is made to the work of Eun Joo Jang, Kyung et al., J. of Molecular Catalysis A, !38(1999)-25-36, wherein they have reported regioselective synthesis of
ibuprofen via palladium complexes. In this process, ibuprofen is synthesised by hydrocarbonylation of l-(4-isobutylyphenyl) ethanol with carbon monoxide and water. This process has disadvantage of the utilisation of carbon monoxide gas, which is hazardous, and very difficult to handle; furthermore, in this process, 4-isobutylacetophenoe is produced by conventional Friedel-Craft acylation of isobutylben/ene.
Reference is made to the work of Botella, P, et al., J. Catal., 195(1), 161-168 (English)2000. Wherein the acylation of toluene was carried out with acetic anhydride over beta zeolite in a stainless-steel autoclave at 150°C by keeping arene /anhydride ratio of 10 to 20.This process is having disadvantages of high temperature and also the need of a large amount of acetic anhydride, which will needed to be separated from the product and unused toluene.
Reference is also made to the Assignee's earlier U.S. Patent No. 6,384,285 titled "Process for the preparation of 4'-isobutylacetophenone" which is incorporated herein as reference. The aforesaid U.S. Patent teaches a process for the preparation of 4'-isobutylacetophenone from isobutylbenzene which comprises reacting isobutylben/ene with acetic anhydride as an acylating agent in the presence of a zeolite beta catalyst at a temperature ranges between 60 to 165.degree. C. for 2-12 h separating the catalyst by filtration from the reaction mixture and recovering the product by a conventional method. The Inventors would like to mention here that the aforesaid US Patent does not teach use of a solvent during the process of acylation of isobutylbenzene using aceticanhydride. The Inventors have surprisingly found that use of some specific solvents during the process of acylation increases the percentage conversion and also the selectivity towards para position. The Applicants have also found that not all solvents are able to increase the percentage conversion and the selectivity. For example, when solvents such as cyclohexane, dichloroethane, dichloromethane and nitromethane are added during the process of acylation, the conversion does not take place. In view of the above, it is submitted that the nature of the solvent added during the process of acylation is very critical. The success of a particular solvent in increasing the percentage conversion and the selectivity cannot be determined merely by extrapolation and it needs lot of research and intellectual input. Hence, the present invention should not be considered as being obvious over the U.S. Patent 6,384,285.
Objects of the Present Invention
The main object of the present invention is to provide an eco-friendly process for
acylation of alkylated benzene derivatives preferably at para position in presence of a
solvent, which obviates the drawbacks as detailed above.
Another object of the process is to provide a process wherein crystalline
aluminosilicate based solid acid heterogeneous catalysts, which are environmentally
friendly and safe in handling are used for acylation of alkylated benzene derivatives.
Still another object of the present invention is to develop crystalline aluminosilicate
catalysts based acylation process for alkylated aromatic compounds, which operates at
moderate conditions of temperature and pressure and yields high conversions with
selectivity towards para acylated product being more than 90%.
Yet another object of the present invention is to provide a process wherein acylating
agent does not generate any hazardous by-product.
Yet another object of the present invention is to provide a process wherein the solvent
added can be easily separated from the products or reactants.
Another object of the present invention is to provide a process wherein acylation of
alkylated aromatic compound is carried out catalytically with high atom utilisation
and low mass ratio of waste to desired product.
Detailed Description of the Present Invention
An ecofriendlv process for acylation of alkylated benzene derivatives preferably in
the para position, said process comprising the steps of:
(a) reacting the alkylated benzene derivatives with an acylating agent such as chloride or anhydride of carboxylic acid or its homologues essentially and selectively in the presence of a solvent selected from the group consisting of nilroben/ene, dichlorobenzene, dimethylsulfolane, benzonitrile or mixtures thereof and a crystalline alumino silicate catalyst having general formula:
M2/nO.Al2O3.xSio2.wH2O
wherein,
M is an alkali and/or rare earth cation or proton, n is valency of M; x is in the SiO2.Al2O3 ratio which is in the range of 3 to 24; W is the weight of water adsorbed which is in the range of 1 to 20%; Si/Al ratio is in the range of 5.5 to 20, and the weight percentage of alkali and/or lanthanide cation is in the range
of 10 to 30the weight percentage of alkali and/or lanthanide cation is in the range of 10 to 30;
at temperature in the range of 80° to 140°C for a time period in the range of 5 to 25 hours;
(b) separating the solid catalyst from the reaction mixture of step (a), and
(c) separating the acylated alkyl benzene derivatives from the mixture of step (b).
In an embodiment of the present invention, the alkylated benzene derivative is
isobutylbenzene.
In another embodiment of the present invention, the acylated alkyl benzene derivative
is isobutylacetophenone.
In yet another embodiment of the present invention, the acylated alkyl benzene
derivative is preferably -isobutylacetophenone.
In still another embodiment of the present invention, the crystalline alumino-silicate
catalyst used is selected from zeolite-Y and Zeolite-p.
In one more embodiment of the present invention, the crystalline alumino-silicate
catalyst is preferably modified using rare earth cations.
In one another embodiment of the present invention, the crystalline alumino-silicate
catalyst is modified using lanthanum and/or cerium in the range of 10 to 30% by
weight.
In a further embodiment of the present invention, the acylating agent is preferably
acetic anhydride.
In a furthermore embodiment of the present invention wherein in step (a), the
alkylated ben/ene derivatives are reacted with acylating agent at atmospheric
conditions.
In an embodiment of the present invention wherein in step (a), the alkylated benzene
derivatives are reacted with acylating agent at temperature in the range of 100" to
140°C and preferably at temperature in the range of 100° to 120°C.
In another embodiment of the present invention, the solid catalyst separated in step (b)
is regenerated for re-use.
In still another embodiment of the present invention, the reaction is generally carried
out at atmospheric pressure. Autogeneous pressure is used when the temperature of
the reaction is more than the boiling points of the reactants and /or products.
In a typical procedure for the preparation of the catalyst, crystalline alumino-silicates
namely zeolite-Y, Beta, ZSM-5 or mordenite in its sodium form was taken and further

treated in following two steps a) conversion to H-form and b) conversion of H-from to lanthanides form. For preparing H-form of the zeolite, 10 grams of sodium zeolite was refluxed with 100 ml of 1M NH4C1 solution for 6 hours at 80 to 100°C. The system was cooled following which the solid catalyst was filtered, washed with hot distilled water till the filtrate became chloride free as tested by AgNO3 and dried in a laboratory oven overnight at 110°C for removing of the moisture. Thus dried sample was calcined at 550°C for 6-10 hours to get H form of zeolite. The catalyst thus obtained was cooled and ambient temperature.
In a typical procedure for the preparation of final zeolite catalysts in lanthanide form, 10 grams of the above prepared zeolite in its H-form was refluxed with 100 ml of 0.01 M solution of soluble salt like nitrate, chloride, or acetate of relative lanthanide cations for 6 to 10 hours at 80 to 100°C. Then the catalyst was filtered after cooling the contents, washed with hot distilled water till the filtrate became anion free and dried in a laboratory oven overnight at 110°C for removing of the moisture. Activation of these prepared catalysts was done at 400°C in air for 4 to 10 hours prior to catalytic studies.
Analysis of above catalysts were done by X-ray diffraction using Philips MPD system, and BHT surface area using Micromeritics ASAP-2010 which clearly indicate the preservation of crystallinity during modification of the catalysts. Catalytic studies using above catalysts were done in a continuous stirred tank reactor (CSTR) of 50 ml capacity equipped with temperature controller, water circulator, magnetic stirrer and moisture trap. Typically, isobutylbenzene and acetic anhydride in the molecular ratio ranging from 1 :1 to 1:3 were taken in a 50ml capacity round bottom flask lo which the activated catalyst was added so as the ratio of isobutylbenzene /catalysts is ranging from 2 to 10. The activation of the catalysts was done at 400 °C for 4 hours. The round bottom flask was fitted with a condenser through which constant temperature water was circulated. Moisture trap was attached at the end of the condenser. The contents of the flask were constantly stirred using a magnetic stirrer. The flask was kept in an oil bath whose temperature was slowly raised to desired reaction temperature. The content of the flask were analysed at different time intervals ranging from 5 to 25 hours by Gas Chromatography, HP model 6890, using capillary column HP-5. Percent conversion of isobutylbenzene was calculated using following equation Percent conversion ~ [no- nf/no] x 100

Where, no Number of moles of alkylated aromatic compound introduced before reaction and nf = Number of moles of alkylated aromatic compound remaining in the reaction mixture after reaction.
In the present invention crystalline alumino-silicate based catalysts are developed for the acylation of isobutylbenzene to produce selectively p-acylated product. Among all these catalysts studied rare earth modified zeolite Beta showed highest activity followed by H-Y, Clays and Mordenite. It is also observed that more polar solvent like nitrobenzene, o-dichlorobenzene and dimethylsulfolane helps to proceed reaction in the forward direction resulting to higher conversion of isobutylbenzene, while non-polar solvent like cyclohexane, hexane are showing less activity. Moreover, low boiling point solvent like dichlorometnae and dichloroethane are not practically utilisable because of solvent vapour loss. It is also observed that isobutylbenzene over acetic anhydride ratio also affect the conversion. The inventive steps in the present work includes,
1. The use of highly selective solvents for increasing the percentage conversion
and the selectivity of the acylation is novel and non-obvious. It should be
noticed here that the use of the solvents may increase as well as decrease the
percentage conversion and the selectivity and only after much trial and error it
can be determined which particular solvent will increase the percentage
conversion of acylation and the selectivity towards para position.
2. Simple modification of crystalline alumino-silicates with rare earth cations in
the range of 10 to 30 weight percent to introduce surface acidity which make
the catalysts more suited for acylation reactions leading to higher conversion
and para position selectivity.
3. The acylation reaction is carried out in single step and separation of the
catalysts from the reaction mixture can be easily done by filtration.
4. The lower temperature and pressure conditions which favour the selectivity
for para position, which is desired.
5. The catalytic reaction proceeds at relatively moderate temperature of 120°C
and at atmospheric pressure, which makes the process energy efficient.
6. Catalysis can be regenerated with a simple process and reused.
The following examples are given by the way of illustrations and therefore should not be constructed to limit the scope of the present invention.

EXAMPLE-1
10 gm of crystalline alumino-silicate namely zeolite-Beta in sodium form was
refluxed with 100ml of 1M aqueous solution of ammonium chloride for 6 hours at 80°C. This was followed by filtration, washing with hot distilled water till the filtrate become chloride free as checked by silver nitrate solution. Thus obtained solid was dried overnight as 11()°C. The dried sample was calcined at 550° C in air for removing ammonia and calcined solid was termed as H- Beta. 0.5 gm of thus prepared catalyst was preactivated [400°C in muffle furnace for 4 hrs. and mixed with 10 milimoles of acetic anhydride and 10 milimoles of isobutylbenzene with 10 ml of nitroben/ene in a 50 ml of two necked round bottom flask. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, condenser and circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 100°C The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylben/ene was 6.35% with 95 % selectivity after 20 hours as shown in table-1.
EXAMPLE-2
0.5 gm of crystalline alumino-silicate namely zeolite-Y was preactivated |400°C in
muffle furnace for 4 hrs.] and mixed with 10 milimoles with acetic anhydride and 10 milimoles of isobutylbenzene with 10 ml of nitrobenzene in a 50 ml of two necked round bottom flask. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and circulator. The temperature of the oil bath was then slowly raised to the desired one i.e. to 100°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 1.38 % with 97 % selectivity after 20 hours as shown in table-1.
EXAMPLE-3
10 gm of crystalline alumino-silicate namely zeolite Na-ZSM-5 was refluxed with
100 ml of 1M aqueous solution of ammonium chloride for 6 hrs. at 80°C .This was followed by filtration, washing with hot distilled water till the filtrate become chloride free as checked by silver nitrate solution. Thus obtained solid was dried overnight as 1 10°C. The dried sample was calcined at 550°C in air for removing ammonia and calcined solid was termed as H- ZSM-5 zeolite. 0.5 gm of thus prepared zeolite catalysts was preactivated [400°C in muffle furnace for 4 hrs.] and mixed with 10

milimoles with acetic-anhydride and 10 milimoles of isobutylbenzene with 10 ml of nitroben/ene in a 50 ml of two necked round bottom flask. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and circulator. The temperature of the oil bath was then slowly raised to 100 ° C. The samples were taken out periodically by means of syringe and analysed by gas chromalography using HP-5 column The percent conversion of isobutylbenzene was nil even after 20 hours as shown in table-1.
EXAMPLE-4
10 gin of crystalline alumino-silicate namely zeolite Na-Mordenite was refluxed with
100 ml of 1M aqueous solution of ammonium chloride for 6 hours at 80°C. This was followed by filtration, washing with hot distilled water till the filtrate become chloride free as checked by silver nitrate solution. Thus obtained solid was dried overnight at I 10°C. The dried sample was calcined at 550° C in air for removing ammonia and calcined solid was termed as H-Mordenite zeolite. 0.5 gm of thus prepared zeolite catalysts was preactivated [400°C in muffle furnace for 4 hrs.] and mixed with 10 milimoles with acetic-anhydride and 10 milimoles of isobutylbenzene with 10 ml of nitroben/ene in a 50 ml of two necked round bottom flask. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 100°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was nil even after 20 hours as shown in table-].
EXAMPLE-5
LO gms of alumino-silicate namely raw montmorrilonite clay was mixed with 10
litres of distilled water and stirred for 24 hours .It was allowed to settle down for 24 hours and then supemant was decant and then clay dried in natural sun light to get upgraded clay in its sodium form. It was then treated with 2NH2SO4 for 6 hours, filtered and washed with hot distilled water to make it free from sulphate as checked with the solution of silver nitrate. 0.5 gm of thus prepared H-Montmorrilonte was mixed with 20 milimoles with acetic-anhydride and 10 milimoles of isobutylbenzene with 10 ml of nitrobenzene in a 50 ml of two necked round bottom flask with preactivaled 1120°C in oven for 12 hrs]. This round bottom flask was then put in an
011 bath equipped with temperature controller magnetic stirrer, condenser and
circulator The temperature of the oil bath was then slowly raised to the desired one,

i.e., to 120°C'. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was nil even after 20 hours as shown in table-1.
EXAMPLE-6
10 gm of crystalline alumino-silicate namely zeolite-Y was refluxed with 100 ml of
0.01M solution of cerium nitrate at 80° C for 6 hours, followed by filtration and washing with hot distilled water to make it free from nitrate as checked by silver nitrate. The resultant solid was dried at 110°C for overnight and calcined at 550°C to get Ce-Y zeolite.
10 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10 ml of nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalysts as prepared above. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, and condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 100°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 2.08 % with 98 % selectivity after 20 hours as shown in table-1.
EXAMPLE-7
10 gm of crystalline alumino-silicate namely zeolite Beta as prepared in Example-1
was refluxed with 100 ml of 0.01 M solution of cerium nitrate at 80°C for six hours, followed by filtration and washing with hot distilled water to make it free from nitrate as checked by silver nitrate. The resultant solid was dried at 110° C for overnight and calcined at 55()°C to get Ce-Beta, 10 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of nitrobenzene were mixed in a 50 ml of two necked round bottom flask with ().5gm of preactivated [400°C in muffle furnace for 4 hrs] catalysts as prepared above. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, condenser and water circulator The temperature of the oil bath was then slowly raised to the desired one i.e. 100°(". The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 11.27% with 95% selectivity after 20 hours as shown in table-!.
EXAMPLE-8

10 gm of crystalline alumino-silicate zeolite Y was refluxed with 100 ml of 0.01 M solution of lanthanum nitrate at 80°C for six hours, followed by filtration and washing with hot distilled water to make it free from nitrate as checked by silver nitrate. The resultant solid was dried at 110° C for overnight and calcined at 550°C to get La-Y zeolite. 10 milimoles of acetic anhydride, 10 milimoles of isobutylben/ene and 10 ml of nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |400°C in muffle furnace for 4 hrs] catalysts as prepared above. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one i.e. 100 ° C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 2 % with 94 % selectivity after 20 hours as shown in table-1.
EXAMPLE-9
10 milimoles of isobutylbenzene, 10 milimoles of acetic anhydride and 10 ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one i.e. to 100 ° C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 6toI5% with selectivity from 92 to 98% in the time interval of 5 to 25 hours as shown in table-2.
EXAMPLE-10
10 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10 ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalysts Ce-Beta, as prepared in Example-7. Phis round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one i.e. to 120 ° C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was

ranging from 8 to 20% with selectivity from 89 to 100 % in the time interval of 5 to 25 hours as shown in table-2.
EXAMPLE-11
10 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10 ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Fxample-7. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 140°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 7.5 to 9.15% with selectivity from 85 to 100% in the time interval of 5 to 25 hours as shown in table-2.
EXAMPLE-12
10 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5coloumn. The percent conversion of isobutylbenzene was ranging from 8.5 to 12.8% with selectivity from 95 to 97% in the time interval of 10 to 20 hours as shown in table-2.
EXAMPLE-13
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |400°C in muffle furnace for 4 hrs] catalysts, Ce-Beta, as prepared in Example-7, This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was

ranging from 34 to 36% with selectivity from 60 to 92 %in the time interval of 10 to 20 hours as shown in table-2.
EXAMPLE-14
30 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |400°C in muffle furnace for 4 hrs] catalysts, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 12 to 16% with selectivity from 72 to 81% in the time interval of 10 to 20 hours as shown in table-2.
EXAMPLE-15
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalysts, Ce-Beta, as prepared in Example - 7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 34 to 36% with selectivity from 89 to 92% in the time interval of 10 to 15 hours as shown in table-2.
EXAMPLE-16
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 5ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Fxample-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., 120°C.The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was

ranging from 13 to 14% with selectivity from 77 to S5% in the time interval of 10 fo 20 hours as shown in table-2.
EXAMPLE-17
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitroben/ene were mixed in a 50 ml of two necked round bottom flask with O.Igm of preactivated [400°C in muffle furnace for 4 hrs] catalysts, Ce-Beta, as prepared in Kxample-7- This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 8 to 20 % with selectivity from 88 to 94% in the time interval of 5 to 10 hours as shown in table-2.
EXAMPLE-18
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitroben/ene were mixed in a 50 ml of two necked round bottom flask with 0.15 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Kxample-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 9 to 19% with selectivity from 88 to 95 % in the time interval of 5 to 10 hours as shown in table-2.
EXAMPLE-19
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.25 grn of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer. condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylben/ene was

ranging from 5 to 13 % with almost 100% selectivity in the time interval of 10 to 20 hours as shown in table-2.
EXAMPLE-20
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Kxample-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature ol the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 10 to 27 to 34% with selectivity from 87 to 89 % in the time interval of 5 to 10 hours as shown in table-2.
EXAMPLE-21
200 milimoies of acetic anhydride, 100 milimoles of isobutylbenzene and 100ml of
nitrobenzene were mixed in a 250 ml of two necked round bottom flask with 5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to I20°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 24 to 31% in with selectivity from 87 to 95% the time interval of 5 to 10 hours as shown in table-2.
EXAMPLE-22
After the reaction described in Example 19, The solid portion was separated by
filtration, washing with acetone till the filtrate became colourless. Thus washed sample was put in oven for overnight at 110° C and then activated at 400°C for 4 hours in a muffle furnace in air prior to use. Thus activated catalysts was mixed with 20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of nitrobenzene were mixed in a 50 ml of two necked round bottom flask. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, condenser and water circulator. The temperature of the oil bath was

then slowly raised to the desired one, i.e., to 12()°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The same process was repeated for further four times and the percent conversion of isobutylbenzene was 37, 36, 22, 8, and 5% with selectivity from 81,81, 90,96 and 96% after 15 hours reaction] time in first, second, third and forth regeneration respectively as shown in table-2.
EXAMPLE-23
The catalysts obtained after first regeneration process as described in Example-21 was
activated at 500°C for 4 hours prior to use. Thus activated catalysts was mixed with 20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of nitrobenzene were mixed in a 50 ml of two necked round bottom flask.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 22 to 30% with selectivity from 83 to 87 %in the time interval of 10 to 15 hours as shown in table-3.
EXAMPLE-24
20.0 milimoles of acetic anhydride, 10.0 milimoles of isobutylbenzene and 10.0 ml of
nitrobenzene were mixed in a 50ml of Parr autoclave with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7. This auto clave is equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the reaction vessel was then slowly raised to the desired one, i.e., to 120°C. After 8 hours of reaction time the autoclave was cooled down and the reaction mixture was analysed by gas chromatography using HP-5 column. The percent conversion of isobutyl benzene was 27% with 90% selectivity after 8 hours reaction time as shown in table-3.
EXAMPLE-25
20 milimoles of acetic anhydride and 10 milimoles of isobutylbenzene were mixed in
a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator, from the top of the condenser

nitrogen gas was slowly passed during the reaction. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 9.87% with 88% selectivity after 10 hrs reaction time as shown in tabIe-3.
EXAMPLE-26
20 milimolcs of acetic anhydride and 10 milimoles of isobutylbenzene were mixed in
a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator, from the top of the condenser argon was slowly passed during the reaction. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 3% with 87% selectivity after 10 hours reaction time as shown in table-3.
EXAMPLE-27
30 inilimoles of acetic anhydride, 10 milimoles of isobutylbenzene mixed in a 50 ml
of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in example-7. This round bottom flask was then put in an oil bath equipped with temperature controller, magnetic stirrer, spiral condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 3 to 6% with 40 to 46% selectivity in the time interval of 10 to 15 hours as shown in table-3.
EXAMPLE-28
60 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene mixed in a 50 ml
of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs| catalyst, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, spiral condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out

periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was ranging from 6 to 8% with 24 to 40% selectivity in the time interval of 10 to 15 hours as shown in table-3.
EXAMPLE-29
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
Dimethylsulfoiane were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 20% with 82% selectivity after 15 hours as shown in table-4.
EXAMPLE-30
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10 ml of
Benzonitrile were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. . The percent conversion of isobutylbenzene was 5.6% with 100% selectivity after 8 hours as shown in table-4.
EXAMPLE-31
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml, of
nitrobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |40()°C in muffle furnace for 4 hrs] catalyst, Ce-Beta. as prepared in Example-7.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 37% with 92% selectivity after 15 hours as shown in table-4.

EXAMPLE-32
20 milimoles of acetic anhydride, 10 miiimoles of isobutylbenzene and 10ml of
dichlorobenzene were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [4()0°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Exam ple-7.This round bottom tlask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e. to I20°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 29% with 88% selectivity after 15 hours as shown in table-4.
EXAMPLE-33
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of acetic
anhydride were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e. to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromiitography using HP-5 column. The percent conversion of isobutylbenzene was 6.6% with 24% selectivity after 15 hours as shown in table-4.
EXAMPLE-34
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
cyclohexane were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta as prepared in Example-7.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer. condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e. to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was nil after 5 hours as shown in table-4.
EXAMPLE-35
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10 ml of
dichloroethanc were mixed in a 50 ml of two necked round bottom flask with 0.5 gm

of" preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was nil after 5 hours as shown in table-4.
EXAMPLE-36
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of
dichloromethane were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |'400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7 This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was nil after 5 hours as shown in table-4.
EXAMPLE-37
20 milimoles of acetic anhydride. 10 milimoles of isobutylbenzene and 10ml of
nitromethane were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated |40()°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7.This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 120°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was nil after 5 hours as shown in table-4.
EXAMPLE-38
20 milimoles of acetic anhydride. 10 milimoles of isobutylbenzene and IOml of Dimethylsulfolane were mixed in a 50 ml of two necked round bottom flask with 0.5 gm of preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e. to 140°C.

The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 16% with 75% selectivity after 15 hours as shown in table-4.
EXAMPLE-39
20 milimoles of acetic anhydride, 10 milimoles of isobutylbenzene and 10ml of chloroben/ene were mixed in a 50 ml of two necked round bottom flask with 0.5gm of
preactivated [400°C in muffle furnace for 4 hrs] catalyst, Ce-Beta, as prepared in Example-7. This round bottom flask was then put in an oil bath equipped with temperature controller magnetic stirrer, condenser and water circulator. The temperature of the oil bath was then slowly raised to the desired one, i.e., to 140°C. The sample were taken out periodically by means of syringe and analysed by gas chromatography using HP-5 column. The percent conversion of isobutylbenzene was 28% with 83 % selectivity after 15 hours as shown in table-4.
TABLE 1
Weight percent conversion of isobutylbenzene and selectivity towards p-acyl isobutylbenzene over different catalysts(Table Removed)
TABLE - 2
Weight percentage conversion of isobutylbenzene and selectivity towards p-acyl isobutylbenzene over different catalysts under different catalysts
Ex. No. (Table Removed)TABLE - 3
Weight percentage conversion of isobutylbenzene and selectivity towards p-acy! isobutylbenzene over different catalysts under different catalysts(Table Removed)TABLE - 4
Weight percentage conversion of isobutylbenzene and selectivity towards p-acyl isobutylbenzene over different catalysts under different catalysts
(Table Removed)




We Claim:
1 . An ecofriendly process for acylation of alkylated benzene derivatives preferably at para position, said process including the steps of
(a) reacting the alkylated benzene derivatives with an acylating agent such as chloride or anhydride of carboxylic acid or its homologues essentially at atmospheric conditions and selectively in the presence of a solvent selected from the group consisting of nitrobenzene. dichlorobenzene, dimethylsulfolane, benzonitrile or mixtures thereof and a crystalline alumino silicate catalyst having general formula:
wherein,
M is an alkali and/or rare earth cation or proton, n is valency of M; x is
in the SiO2/Al2O3 ratio which is in the range of 3 to 24; W is the
weight of water adsorbed which is in the range of 1 to 20%; Si/Al ratio
is in the range of 5.5 to 20, and the weight percentage of alkali and/or
lanthanide cation is in the range of 10 to 30;
at temperature in the range of 80° to 140°C for a time period in the
range of 5 to 25 hours;
(b) separating the solid catalyst from the reaction mixture of step (a), and
(c) separating the acylated alkyl benzene derivatives from the mixture of
step (b).

2. A process as claimed in claim 1, wherein the alkylated benzene derivative is
isobutylbenzene.
3. A process as claimed in claim 1, wherein the acylated alkyl benzene derivative
is isobutylacetophenone.
4. A process as claimed in claim 1, wherein the acylated alkyl benzene derivative
is preferably p-isobutylacetophenone.
5. A process as claimed in claim 1, wherein the crystalline alumino-silicate
catalyst used is selected from zeolite-Y and Zeolite-p.
6. A process as claimed in claim 1, wherein the crystalline alumino-silicaie
catalyst is preferably modified using rare earth cations.
7. A process as claimed in claim 1, wherein the crystalline alumino-silicatc
catalyst is modified using lanthanum and/or cerium in the range of 10 to 30%
by weight.
8. A process as claimed in claim 1, wherein the acylating agent is preferably
acetic anhydride.
9. A process as claimed in claim 1 wherein in step (a), the alkylated benzene
derivatives are reacted with acylating agent at temperature in the range of 100°
to 140°C and preferably at temperature in the range of 100° to 120°C.
10. A process as claimed in claim 1, wherein the solid catalyst separated in step
(b) is regenerated for re-use.
11. A process as claimed in claim 1, wherein the conversion weight percent of
alkylated benzene derivatives is in the range of 5 to 40 %.
12. A process as claimed in claim 1, wherein the percentage selectivity towards
para position is in the range of 70 to 100%.
13. An ecofriendly process for acylation of alkylated benzene derivatives
preferably at para position at atmospheric conditions substantially as herein
describe with reference to examples accompanying this specification.


Documents:

2923-DELNP-2004-Abstract-(05-03-2009).pdf

2923-delnp-2004-abstract.pdf

2923-DELNP-2004-Claims-(05-03-2009).pdf

2923-delnp-2004-claims.pdf

2923-DELNP-2004-Correspondence-Others-(05-03-2009).pdf

2923-DELNP-2004-Correspondence-Others-(13-03-2009).pdf

2923-delnp-2004-correspondence-others.pdf

2923-DELNP-2004-Description (Complete)-(05-03-2009).pdf

2923-delnp-2004-description (complete).pdf

2923-DELNP-2004-Form-1-(05-03-2009).pdf

2923-delnp-2004-form-1.pdf

2923-delnp-2004-form-18.pdf

2923-DELNP-2004-Form-2-(05-03-2009).pdf

2923-delnp-2004-form-2.pdf

2923-DELNP-2004-Form-3-(05-03-2009).pdf

2923-delnp-2004-form-3.pdf

2923-delnp-2004-form-5.pdf

2923-DELNP-2004-Petition-137-(05-03-2009).pdf


Patent Number 247645
Indian Patent Application Number 2923/DELNP/2004
PG Journal Number 18/2011
Publication Date 06-May-2011
Grant Date 29-Apr-2011
Date of Filing 29-Sep-2004
Name of Patentee COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
Applicant Address RAFI MARG, NEW DELH-110 001, INDIA.
Inventors:
# Inventor's Name Inventor's Address
1 DR R V JASRA CENTRAL SALT & MARINE CHEMICALS RESEARCH INSTITUTE, BHAVNAGAR 364 002, GUJARAT
2 DR BEENA TYAGI CENTRAL SALT & MARINE CHEMICALS RESEARCH INSTITUTE, BHAVNAGAR 364 002, GUJARAT
3 MR YOGIRAJ MANSUKLAL BADHEKA CENTRAL SALT & MARINE CHEMICALS RESEARCH INSTITUTE, BHAVNAGAR 364 002, GUJARAT
PCT International Classification Number C07 C45/45
PCT International Application Number PCT/IN03/00439
PCT International Filing date 2003-12-31
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 10/678902 2003-10-02 U.S.A.