Title of Invention

A COMPOSITION USEFUL IN DEVELOPING AN ARTIFICIAL BONE MARROW-LIKE ENVIRONMENT

Abstract A composition useful in developing an artificial bone marrow-like environment (ABME) for regulating formulating of blood cells, comprising: a) a culture of mesenchymal cells; b) a growth medium selected from Iscove’s modified Dulbecco’s Medium (IMDM), Dulbecco’s modified eagle medium (DMEM), Alpha-minimum essential medium (MEM), RPMI-1640 supplemented with Fetal Bovine Serum (FBS) and optionally supplemented with mthyl cellulse, erythropoietin, hematopoietic growth and differentiation factors, Interleukins; c) a hematopoietic modulator or plurality of modulators capable of activating intracellular signalling; wherein the hematopoietic modulator(s) such as hereindescribed selected from any of: a biological agent, a chemical agent and an immunological agent; and d) a support for the cells comprising constituents of extra cellular matrix or their mimetics capable of forming a matrix in two or more dimensions.
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Documents:


Patent Number 247460
Indian Patent Application Number 230/MUM/2005
PG Journal Number 15/2011
Publication Date 15-Apr-2011
Grant Date 08-Apr-2011
Date of Filing 01-Mar-2005
Name of Patentee NATIONAL CENTRE FOR CELL SCIENCE
Applicant Address NCCS CAMPUS, GANESHKHIND ROAD, PUNE 411007
Inventors:
# Inventor's Name Inventor's Address
1 VAIJAYANTI PRAKASH KALE NATIONAL CENTER FOR CELL SCIENCE NCCS CAMPUS, GANESHKHIND ROAD, PUNE 411007
2 LAKSHMI CHARAN PADHY TATA INSTITITE OF FUNDAMENTAL RESEARCFH HOMI BHABHA ROAD, COLABA, MUMBAI 400005
PCT International Classification Number C12N5/06
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA