Title of Invention

"AN AZITHROMYCIN COMPOSITION"

Abstract An azithromycin composition comprising: (a) from about 0.018 to about 0.301 weight ratio of an alkalizing agent; and (b) multiparticulates wherein said multiparticulates comprise (i) about 20% to about 75% azithromycin, (ii) about 25% to about 80% of a glyceride, which comprises glyceryl monobehenate, glyceryl dibenenate, glyceryl tribehenate, and mixtures thereof; and (iii) a poloxamer such as herein described.
Full Text Description (Complete) PRINT PROBLEM










WE CLAIM:
1. An azithromycin composition comprising:
(a) from about 0.018 to about 0.301 weight ratio of an alkalizing agent; and
(b) multiparticulates wherein said multiparticulates comprise
(i) about 20% to about 75% azithromycin,
(ii) about 25% to about 80% of a glyceride, which comprises
glyceryl monobehenate, glyceryl dibenenate, glyceryl
tribehenate, and mixtures thereof; and (iii) a poloxamer such as herein described.
2. The composition as claimed in Claim 1, wherein the poloxamer comprises poloxamer 407.
3. The composition as claimed in Claim 2, wherein the alkalizing agent comprises tribasic sodium phosphate.
4. The composition as claimed in Claim 3 wherein the alkalizing agent comprises magnesium hydroxide.
5. The composition as claimed in Claims 1 to 3 wherein it optionally comprises about 250 mgA to about 7 gA of azithromycin.
6. The composition as claimed in Claim 5, comprising 1.8 to 2.2 gA of azithromycin.
7. The composition as claimed in claim 4, wherein it comprises:

(a) at least about 200mg of tribasic sodium phosphate;
(b) at least about 100 mg of magnesium hydroxide, and
(c) multiparticulates, wherein said multiparticutates comprise (i) azithromycin,
(ii) a mixture of glyceryl monobehenate, glyceryl dibehenate
and glyceryl tribehenate, and
(iii) poloxamer 407,
and wherein said dosage form contains about 1.5 gA to about 4 gA of azithromycin.
8. The composition as claimed in Claim 7, wherein the alkalizing agent
comprises:
(a) 300 mg to 400 mg of tribasic sodium phosphate; and
(b) 200 mg to 300 mg of magnesium hydroxide.
9. The composition as claimed in Claim 8, wherein it comprises 1.8 to 2.2
gA of azithromycin.
10. The composition as claimed in Claims 1 to 3, and 7 to 9 wherein said azithromycin is azithromycin dihydrate.
11. The composition as claimed in claims 1 to 3 and 7 to 9 wherein said azithromycin is at least 70 wt% crystalline.


Documents:

978-del-2004-abstract.pdf

978-del-2004-claims.pdf

978-DEL-2004-Correspondence-Others-(18-06-2010).pdf

978-del-2004-correspondence-others.pdf

978-del-2004-correspondence-po.pdf

978-del-2004-description (complete).pdf

978-del-2004-drawings.pdf

978-del-2004-form-1.pdf

978-del-2004-form-18.pdf

978-del-2004-form-2.pdf

978-DEL-2004-Form-3-(18-06-2010).pdf

978-del-2004-form-3.pdf

978-del-2004-form-5.pdf

978-del-2004-gpa.pdf

978-del-2004-petition 137.pdf

978-del-2004-petition 138.pdf


Patent Number 247177
Indian Patent Application Number 978/DEL/2004
PG Journal Number 13/2011
Publication Date 01-Apr-2011
Grant Date 29-Mar-2011
Date of Filing 28-May-2004
Name of Patentee PFIZER PRIDUCTS INC.
Applicant Address EASTERN POINT ROAD,GROTON,CONNECTICUT 06340,U.S.A
Inventors:
# Inventor's Name Inventor's Address
1 TIMOTHY ARTHUR HAGEN PFFIZER GLOBAL RESEARCH AND DEVELOPMENT,EASTERN POINT ROAD,GROTON,CONNECTICUT 06340,U.S.A
2 SCOTT MAX HERBIG PFFIZER GLOBAL RESEARCH AND DEVELOPMENT,EASTERN POINT ROAD,GROTON,CONNECTICUT 06340,U.S.A
3 JULIAN BELKNAP LO PFFIZER GLOBAL RESEARCH AND DEVELOPMENT,EASTERN POINT ROAD,GROTON,CONNECTICUT 06340,U.S.A
4 AVINASH GOVIND THOMBRE PFFIZER GLOBAL RESEARCH AND DEVELOPMENT,EASTERN POINT ROAD,GROTON,CONNECTICUT 06340,U.S.A
5 LEAH ELIZABETH APPEL BEND RESEARCH INC,64550 RESEARCH ROAD,BEND,OREGON 97701,U.S.A
6 MARSHELL DAVID CREW BEND RESEARCH INC,64550 RESEARCH ROAD,BEND,OREGON 97701,U.S.A
7 DWAYNE THOMAS FRIESEN BEND RESEARCH INC,64550 RESEARCH ROAD,BEND,OREGON 97701,U.S.A
8 DAVID KEITH LYON BEND RESEARCH INC,64550 RESEARCH ROAD,BEND,OREGON 97701,U.S.A
9 SCOTT BALDWIN MCCRAY BEND RESEARCH INC,64550 RESEARCH ROAD,BEND,OREGON 97701,U.S.A
10 JAMES BLAIR WEST BEND RESEARCH INC,64550 RESEARCH ROAD,BEND,OREGON 97701,U.S.A
PCT International Classification Number A61P 13/00
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 10/763,340 2004-01-23 U.S.A.
2 60/527,084 2003-12-04 U.S.A.