| Title of Invention | NOVEL INTERMEDIATES AND AN IMPROVED PROCESS FOR THE PREPARATION OF TOLTERODINE EMPLOYING THE SAID INTERMEDIATES |
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| Abstract | The present invention relates to a novel and improved process for the preparation of tolterodine of formula I. Key steps involved in the process are a vinyl Grignard reactioll on a benzophenone derivative of formula XXI to get the vinyl carbinol derivative of formula XXII and rearrangement of the carbinol derivative to an allylic alcohol derivative of formula XXIII to get the required carbon framework. Compound of formula XXIII is further converted to tolterodine in four steps. Tolterodine is a muscarinic receptor antagonist useful in treatment of urinary urge incontinence and other symptoms of bladder over activity. |
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1421-CHE-2005 AMENDED CLAIMS 15-12-2010.pdf
1421-CHE-2005 AMENDED PAGES OF SPECIFICATION 15-12-2010.pdf
1421-CHE-2005 EXAMINATION REPORT REPLY RECIEVED 15-12-2010.pdf
1421-CHE-2005 CORRESPONDENCE OTHERS.pdf
1421-CHE-2005 CORRESPONDENCE PO.pdf
| Patent Number | 246095 | ||||||||||||
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| Indian Patent Application Number | 1421/CHE/2005 | ||||||||||||
| PG Journal Number | 07/2011 | ||||||||||||
| Publication Date | 18-Feb-2011 | ||||||||||||
| Grant Date | 14-Feb-2011 | ||||||||||||
| Date of Filing | 06-Oct-2005 | ||||||||||||
| Name of Patentee | NATCO PHARMA LIMITED | ||||||||||||
| Applicant Address | NATCO PHARAMA LIMITED NATCO HOUSE, ROAD NO.2, BANJARA HILLS, HYDERABAD | ||||||||||||
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| PCT International Classification Number | C07C 213/02 | ||||||||||||
| PCT International Application Number | N/A | ||||||||||||
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PCT Conventions:
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