Title of Invention

NOVEL INTERMEDIATES AND AN IMPROVED PROCESS FOR THE PREPARATION OF TOLTERODINE EMPLOYING THE SAID INTERMEDIATES

Abstract The present invention relates to a novel and improved process for the preparation of tolterodine of formula I. Key steps involved in the process are a vinyl Grignard reactioll on a benzophenone derivative of formula XXI to get the vinyl carbinol derivative of formula XXII and rearrangement of the carbinol derivative to an allylic alcohol derivative of formula XXIII to get the required carbon framework. Compound of formula XXIII is further converted to tolterodine in four steps. Tolterodine is a muscarinic receptor antagonist useful in treatment of urinary urge incontinence and other symptoms of bladder over activity.
Full Text

Documents:

1421-CHE-2005 AMENDED CLAIMS 15-12-2010.pdf

1421-CHE-2005 AMENDED PAGES OF SPECIFICATION 15-12-2010.pdf

1421-CHE-2005 EXAMINATION REPORT REPLY RECIEVED 15-12-2010.pdf

1421-CHE-2005 CORRESPONDENCE OTHERS.pdf

1421-CHE-2005 CORRESPONDENCE PO.pdf

1421-CHE-2005 FORM 1.pdf

1421-CHE-2005 FORM 18.pdf

1421-CHE-2005 FORM 3.pdf

1421-CHE-2005 FORM 5.pdf


Patent Number 246095
Indian Patent Application Number 1421/CHE/2005
PG Journal Number 07/2011
Publication Date 18-Feb-2011
Grant Date 14-Feb-2011
Date of Filing 06-Oct-2005
Name of Patentee NATCO PHARMA LIMITED
Applicant Address NATCO PHARAMA LIMITED NATCO HOUSE, ROAD NO.2, BANJARA HILLS, HYDERABAD
Inventors:
# Inventor's Name Inventor's Address
1 PULLA REDDY MUDDASANI NATCO PHARAMA LIMITED NATCO HOUSE, ROAD NO.2, BANJARA HILLS, HYDERABAD -500 033
2 PEDDI RAJASEKHARA REDDY NATCO PHARAMA LIMITED NATCO HOUSE, ROAD NO.2, BANJARA HILLS, HYDERABAD 500 033
3 VENKAIAH CHOWDARY NANNAPANENI NATCO PHARAMA LIMITED NATCO HOUSE, ROAD NO.2, BANJARA HILLS, HYDERABAD 500 033, ANDRA PRADESH, INDIA
PCT International Classification Number C07C 213/02
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA