Title of Invention

NOVEL THROMBOLYTIC MOLECULES AND A PROCESS THEREFOR

Abstract The invention discloses a new thrombolytic protein molecules such as recombinant staphylokinase or streptokinase, urokinase, tissue plasminogen activator and the like, and is suitable to their variants thereof, for targeting to brain tissue or any other tissue by either fusing to, or by synthesizing the candidate thrombolytic molecule( s) with a protein sequence comprising a strong amphipathic alpha helix containing protein transduction domain. Thrombolytic protein molecule(s) so engineered with the protein transduction domain is useful for enhanced uptake of such protein thrombolytic molecule(s) across the cell membranes and tissues including the blood brain barrier and find their use in the treatment of vascular thrombosis including cerebrovascular disorders caused by cerebral thrombosis or cerebral haemorrhage when used a as a therapeutic. The invention discloses the design and processes for cloning, expression, purification and protein transduction of such proteins across cell membranes.
Full Text

Documents:

843-CHE-2006 AMENDED CLAIMS 13-10-2010.pdf

843-CHE-2006 AMENDED PAGES OF SPECIFICATION 13-10-2010.pdf

843-CHE-2006 EXAMINATION REPORT REPLY RECEIVED 13-10-2010.pdf

843-CHE-2006 FORM-3 13-10-2010.pdf

843-che-2006 correspondence others 05-01-2011.pdf

843-che-2006 amended claims 05-01-2011.pdf

843-CHE-2006 CORRESPONDENCE OTHERS 16-04-2012.pdf

843-CHE-2006 FORM-13 16-04-2012.pdf

843-che-2006 form-3 05-01-2011.pdf

843-CHE-2006 POWER OF ATTORNEY 16-04-2012.pdf

843-che-2006 abstract.pdf

843-che-2006 correspondance - others.pdf

843-CHE-2006 CORRESPONDENCE OTHERS.pdf

843-CHE-2006 CORRESPONDENCE PO.pdf

843-che-2006 description provisional.pdf

843-che-2006 form 1.pdf

843-CHE-2006 FORM 18.pdf

843-CHE-2006 FORM 3.pdf

843-CHE-2006 FORM 5.pdf

843-CHE-2006 POWER OF ATTORNEY.pdf


Patent Number 245854
Indian Patent Application Number 843/CHE/2006
PG Journal Number 06/2011
Publication Date 11-Feb-2011
Grant Date 03-Feb-2011
Date of Filing 12-May-2006
Name of Patentee M/S. BHARAT BIOTECH INTERNATIONAL LIMITED
Applicant Address BHARAT BIOTECH INTERNATIONAL LIMITED GENOME VALLEY, TRUKAPALLY, SHAMEERPET, HYDERABAD 500 078.
Inventors:
# Inventor's Name Inventor's Address
1 ELLA KRISHNA MURTHY BHARAT BIOTECH INTERNATIONAL LIMITED GENOME VALLEY, TRUKAPALLY, SHAMEERPET, HYDERABAD 500 078.
2 SUMATHY K. BHARAT BIOTECH INTERNATIONAL LIMITED GENOME VALLEY, TRUKAPALLY, SHAMEERPET, HYDERABAD 500 078, INDIA
PCT International Classification Number A61K 38/16
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA