Title of Invention | NOVEL THROMBOLYTIC MOLECULES AND A PROCESS THEREFOR |
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Abstract | The invention discloses a new thrombolytic protein molecules such as recombinant staphylokinase or streptokinase, urokinase, tissue plasminogen activator and the like, and is suitable to their variants thereof, for targeting to brain tissue or any other tissue by either fusing to, or by synthesizing the candidate thrombolytic molecule( s) with a protein sequence comprising a strong amphipathic alpha helix containing protein transduction domain. Thrombolytic protein molecule(s) so engineered with the protein transduction domain is useful for enhanced uptake of such protein thrombolytic molecule(s) across the cell membranes and tissues including the blood brain barrier and find their use in the treatment of vascular thrombosis including cerebrovascular disorders caused by cerebral thrombosis or cerebral haemorrhage when used a as a therapeutic. The invention discloses the design and processes for cloning, expression, purification and protein transduction of such proteins across cell membranes. |
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843-CHE-2006 AMENDED CLAIMS 13-10-2010.pdf
843-CHE-2006 AMENDED PAGES OF SPECIFICATION 13-10-2010.pdf
843-CHE-2006 EXAMINATION REPORT REPLY RECEIVED 13-10-2010.pdf
843-CHE-2006 FORM-3 13-10-2010.pdf
843-che-2006 correspondence others 05-01-2011.pdf
843-che-2006 amended claims 05-01-2011.pdf
843-CHE-2006 CORRESPONDENCE OTHERS 16-04-2012.pdf
843-CHE-2006 FORM-13 16-04-2012.pdf
843-che-2006 form-3 05-01-2011.pdf
843-CHE-2006 POWER OF ATTORNEY 16-04-2012.pdf
843-che-2006 correspondance - others.pdf
843-CHE-2006 CORRESPONDENCE OTHERS.pdf
843-CHE-2006 CORRESPONDENCE PO.pdf
843-che-2006 description provisional.pdf
843-CHE-2006 POWER OF ATTORNEY.pdf
Patent Number | 245854 | |||||||||
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Indian Patent Application Number | 843/CHE/2006 | |||||||||
PG Journal Number | 06/2011 | |||||||||
Publication Date | 11-Feb-2011 | |||||||||
Grant Date | 03-Feb-2011 | |||||||||
Date of Filing | 12-May-2006 | |||||||||
Name of Patentee | M/S. BHARAT BIOTECH INTERNATIONAL LIMITED | |||||||||
Applicant Address | BHARAT BIOTECH INTERNATIONAL LIMITED GENOME VALLEY, TRUKAPALLY, SHAMEERPET, HYDERABAD 500 078. | |||||||||
Inventors:
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PCT International Classification Number | A61K 38/16 | |||||||||
PCT International Application Number | N/A | |||||||||
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PCT Conventions:
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