Title of Invention

AN ORAL VANADIUM CONJUGATE

Abstract A vanadium complex of polyhydroxy flavone, QT 46, isolated from indian medicinal plant, viz. rosa centifolia has been synthesized, structurally characterized, and evaluated as a potential insulin-mimetic agent using in vitro and in vivo assays. When administered orally at a one-time dose of 0.4 mmol kg‾¹ body weight the present vanadium conjugate lowered blood glucose in streptozotocin-induced diabetic mice twice than that of clinically approved drug bis(maltoloto)oxovanadium (IV), BMOV. The compound was found to accelerate differentiation of 3T3-L1 fibroblasts to adipocytes and mimicked mitogenic potential of insulin as evaluated by [H³] thymidine uptake assay. Present study documents highly remarkable potential of the vanadium-QT 46 conjugate as an insulin-mimetic agent for the treatment of both type 1 and 2 diabetes without any noticeable toxic effects.
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Documents:

405-MUM-2004-ABSTRACT(1-4-2004).pdf

405-MUM-2004-ABSTRACT(2-12-2009).pdf

405-MUM-2004-ABSTRACT(GRANTED)-(13-1-2011).pdf

405-MUM-2004-CANCELLED PAGES(2-12-2009).pdf

405-MUM-2004-CLAIMS(30-3-2005).pdf

405-MUM-2004-CLAIMS(AMENDED)-(2-12-2009).pdf

405-MUM-2004-CLAIMS(GRANTED)-(13-1-2011).pdf

405-MUM-2004-CORRESPONDENCE(14-3-2007).pdf

405-MUM-2004-CORRESPONDENCE(9-8-2010).pdf

405-MUM-2004-CORRESPONDENCE(IPO)-(1-2-2011).pdf

405-MUM-2004-DESCRIPTION(COMPLETE)-(30-3-2005).pdf

405-MUM-2004-DESCRIPTION(GRANTED)-(13-1-2011).pdf

405-MUM-2004-DESCRIPTION(PROVISIONAL)-(1-4-2004).pdf

405-MUM-2004-DRAWING(30-3-2005).pdf

405-MUM-2004-DRAWING(GRANTED)-(13-1-2011).pdf

405-MUM-2004-DRAWING(PROVISIONAL)-(1-4-2004).pdf

405-MUM-2004-FORM 1(1-4-2004).pdf

405-MUM-2004-FORM 1(2-12-2009).pdf

405-MUM-2004-FORM 1(30-3-2005).pdf

405-MUM-2004-FORM 18(15-3-2007).pdf

405-MUM-2004-FORM 2(COMPLETE)-(30-3-2005).pdf

405-MUM-2004-FORM 2(GRANTED)-(13-1-2011).pdf

405-MUM-2004-FORM 2(PROVISIONAL)-(1-4-2004).pdf

405-MUM-2004-FORM 2(TITLE PAGE)-(2-12-2009).pdf

405-MUM-2004-FORM 2(TITLE PAGE)-(COMPLETE)-(30-3-2005).pdf

405-MUM-2004-FORM 2(TITLE PAGE)-(GRANTED)-(13-1-2011).pdf

405-MUM-2004-FORM 2(TITLE PAGE)-(PROVISIONAL)-(1-4-2004).pdf

405-MUM-2004-FORM 26(9-8-2010).pdf

405-MUM-2004-FORM 3(1-4-2004).pdf

405-MUM-2004-FORM 3(2-12-2009).pdf

405-MUM-2004-FORM 5(2-12-2009).pdf

405-MUM-2004-FORM 5(30-3-2005).pdf

405-MUM-2004-REPLY TO EXAMINATION REPORT(2-12-2009).pdf


Patent Number 245326
Indian Patent Application Number 405/MUM/2004
PG Journal Number 03/2011
Publication Date 21-Jan-2011
Grant Date 13-Jan-2011
Date of Filing 01-Apr-2004
Name of Patentee NATIONAL CENTRE FOR CELL SCIENCE
Applicant Address PUNE UNIVERSITY CAMPUS GANESHKHIND ROAD PUNE 411 007
Inventors:
# Inventor's Name Inventor's Address
1 VIVEK BARVE OF PUNE UNIVERSITY, GANESHKIND ROAD, PUNE
2 RUCHI SHUKLA OF NATIONAL CENTRAL FOR CELL SCIENCE, PUNE UNIVERSITY CAMPS, GANESHKIND ROAD, PUNE
3 SUBHASH PADHYE OF PUNE UNIVERSITY, GANESHKIND
4 RAMESH RAMCHANDRA BHONDE OF NATIONAL CENTRE FOR CELL SCIENCE PUNE UNIVERSITY CAMPS, GANESHKIND ROAD
PCT International Classification Number C07D49/10
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA