Title of Invention

"A HERBAL COMPOSITION AGAINST BRONCHIAL ASTHMA AND PROCESS FOR PREPARATION THEREOF"

Abstract This invention relates to a herbal composition for the treatment of Bronchial Asthma comprising of 5 to 6% by weight of Alsi seeds Linum usitatissimum linn, 12 to 14% by weight of Methi seeds Trigonella foenum-graecum linn, 25 to 27% by weight of Seer fruits Allium sativum Linn, 43 to 45% by weight of chilbeenj seeds Strychnos potatorum, 5 to 6% by weight of Meghz-c-karanj kernal pongamia glabra vent, 5 to 6% by weight of Meghz-e-Karanjwa kernel Coesalpinia bonducella flem, garlic and purified water in the ratio of 1:3 to 1:3.5 and honey and all herbs in the ratio by weight of 2:1 to 2:1.5, and 0.15% sodium benzoate as preservative.
Full Text FIELD OF INVENTION
This invention relates to a herbal composition against bronchial asthma and process for preparation of the formulation.
PRIOR ART
Bronchial asthma is a diffused involvement of bronchial system due to various influences resulting in chronic respiratory disability ranging from broncho spasm, which is easily reversible, to severe chronic intractable obstruction to air flow. The disease is characterised by paroxysmal attacks of dyspnoea with a short inspiratory effect and prolonged expiration and is caused by narrowing of trachea bronchi and bronchioles. Though the attack of disease can occur anywhere, at any time, yet the attack of disease, often, occurs in early hours of morning, with patient waking up with the feeling of tightness in the chest. The attack begins with a cough to gasp for breath and if attack is severe the patient stands up by an open window for breathing. An attack may be mild, moderate or severe and can last for a few minutes, hours or days. When it is prolonged, it is called status asthmatics. The dust, smoke, pollution in air and infection are regarded to be the main factors for causation of the disease.
One of a Unani herbal formulation for treatment of the disease, known in the art is "Laooq Nazli" which is a mixture of seven herbs namely Aslusoos, Bahidana, Tukhm Khatmi, Tukfini Khaskhas Sufaid, Rubbusoos, Kateera, Gond Babool and Sugar.
A limitation of flie a£ove formulation is that it has no effect on allergic bronchial asthma.
Another limitation of the above formulation is that it works only as expectorant and provides temporary relief to symptoms.
Still another limitation of the above formulation is that it provides no relief when attack of asthma occurs.
Another Unani herbal formulation known in the art is "Majoon Rahul Momenin" which comprises of twelve herbs namely Irsa, Berg Gaozuban, Tukhm Gazar, Salab Misri, Jaiphal, Darchini, Shaqaqal Misri, Kateera Sufaid, Maghz Chilghoza, Maghz Narjeel, Post Khaskhash, Tukhm Khaskhash and Sugar.
A drawback of the above formulation is that it is relatively costlier.
Another limitation of the above formulation is that it is not effective on allergic bronchial asthma.
Still another drawback of the above formulation is that it provides temporary relief as an expectorant.
Still another known Unani herbal formulation for treatment of bronchial asthma known as 'Sharbat sadar' consists of fifteen herbs namely Abresham, Ajwain, Aslusoos, Alsi, Anjeer Zard, Badiyan, Berg Aroosa, Berg Gaozuban, Parsiyaoshan, Tukhm Khubazi, Zoofa, Sapistan, Unnab, Post Khaskhash, Gul Gaozuban and Sugar.
A drawback of the above formulation is that it is relatively costlier.
Another drawback of the above formulation is that it is also not effective on allergic bronchial asthma.
Still another drawback of the above formulation is that it also provides relief as an expectorant.
Yet another Unani herbal formulation known as "Triyaq Nazla' for treatment of the disease consists of thirteen herbs namely Ajwain khurasani, Ustokhuddus, Post Khaskhash, Tukhm Khaskhash, Tukhm Kahu, Kashneez, Gul Gaozuban, Rubbusoos, Kateera, Gul Surkh, Gond Keekar, Murmakki, Nishasta Gandum and Sugar.
A drawback of the above formulation is that it works like an expectorant and provides a soothing effect which gives temporary relief.
Another drawback of the above formulation is that it is relatively costlier.
OBJECTS OF THE PRESENT INVENTION
The main object of the present invention is to provide a therapeutic herbal composition for effective treatment of bronchial asthma.
Another object of the present invention is to provide a therapeutic herbal composition for treatment of bronchial asthma, which has no toxicity or untoward effect even after prolonged administration.
Still another object of the present invention is to provide a therapeutic herbal composition which has no toxic effect ever for children or pregnant women.
Further object of the present invention is to provide a therapeutic herbal composition which is based on commonly available herbs.
Yet further object of the present invention is to provide a herbal composition which is cheap.
STATEMENT OF INVENTION
According to this invention there is provided a herbal composition for the treatment of Bronchial Asthma comprising of 5 to 6% by weight of Alsi seeds Linum usitatissimum linn, 12 to 14% by weight of Methi seeds Trigonella foenum-graecum linn, 25 to 27% by weight of Seer fruits Allium sativum Linn, 43 to 45% by weight of chilbeenj seeds Strychnos potatorum, 5 to 6% by weight of Meghz-c-karanj kernal pongamia glabra vent, 5 to 6% by weight of Meghz-e-Karanjwa kernel Coesalpinia bonducella flem, garlic and purified water in the ratio of 1:3 to 1:3.5 and honey and all herbs in the ratio by weight of 2:1 to 2:1.5, and 0.15% sodium benzoate as preservative.
DESCRIPTION OF INVENTION
According to this invention, the herbal composition of the present invention is prepared by the process comprising steps of:-
Preparation of garlic extract
Fresh garlic taken in quantity varying from 15-20% by weight of honey, is deskinned and subjected to hot extraction at 100-150°C, using purified water as solvent. The garlic and water are preferably taken in w/v ratio varying from 1:3 to 1:3.5. At least three extractions are made and all extracts are pooled together and subjected to evaporation till extract is reduced by 2 to 5%. The extract is passed through activated charcoal taken preferably in quantity 10% w/v of the volume of the filtrate. The filtrate after passing through activated charcoal is finally reduced to about 50%.
Preparation of mixture of honey and garlic extract
Honey taken in quantity in the ratio by weight of 2:1 with respect to the total weight of all herbs taken together, is separately heated at low temperature of 50-60°C so as to bring it to molten state. The garlic extract obtained as above is added to the molten honey. The heating is continued and the whole mass is allowed to evaporate till the mass is concentrated to about 80% and thereafter heating is discontinued.
Preparation of mixture of herbs
A mixture of herbs is separately prepared by taking Alsi (Linum usitatissimum Linn.) in quantity 5 to 6% by weight of total weight of all herbs, Methi {TrigoneHa foemum-graecum Linn.) in quantity 12 to 14% by weight, Seer {Allium sativum Linn.) taken in quantity 25 to 27% by weight of all herbs, Chilbeenj {Strychnos potatorum seeds ) in quantity 43 to 45% by weight of quantity of all herbs, Maghze Karanj ( Pongamia glabra vent) in quantity 5 to 6% by weight of all herbs, and Maghze Karanjwa {Caesalpinia bonducella flem) taken in quantity 5 to 6% by weight of all herbs. The mixture is grinded to a fine powder.
(d) Preparation of the herbal composition
The mixture of herbs prepared as above is added to the concentrated mixture of honey and garlic extract as obtained by step (b) above. The mixture thus obtained is mixed thoroughly and 0.15% sodium benzoate is added to this mixture, as preservative.
This invention will now be illustrated with a working example which is intended to illustrate the working of the invention and is not intended to be taken restrictively to imply any limitation on the scope of the present invention.
WORKING EXAMPLE
2kg of fresh garlic was deskinned and was subjected to hot extraction at 100°C using purified water as solvent. The extraction was made three times and the extracts were pooled together and the total extract was about 2650ml. The extract was passed through activated charcoal and the total filtrate obtained was about 1.3 litres. 12kg of honey was separately heated at low temperature of 50°C to bring it to molten state. To this, garlic extract was added and mixture thoroughly mixed. The whole mass was allowed to evaporate till the mass was concentrated to about 80% and thereafter heating was discontinued. A mixture of herbs was separately prepared by taking 400g of Alsi, 800mg of Methi, 1.6kg of Seer, 2.8kg of Chilbeenj and 400g of Maghze Karanjwa. This mixture of herbs was grinded to a fine powder and added to the extract of honey and garlic as obtained above. The mixture thus prepared was thoroughly mixed and 0.15% sodium benzoate was added as preservative.
It is to be noted that the herbal composition of the present invention is not a mere admixture of the ingredients as there is no mere aggregation of properties. None of the ingredients alone, has any healing quality as such, for treatment of bronchial asthma.
Toxicological studies have been conducted on animal models. No untoward side effect has been observed on any of the vital organs. The formulation is well tolerated and completely safe even on long term. Clinical studies have also been carried out with the herbal formulation of the present invention. Study was undertaken on a total of 2086 cases. Significant therapeutic response has been noted both in intrinsic and extrinsic type of cases. Seventy four percent cases have responded to the treatment. The formulation has proved to have the following properties-
(i) It acts as bronchodilator, antihistaminic, emulcificient and expectorant.
(ii) It corrects various stages of digestion.
(iii) It increases the lungs function towards normal.
(iv) Reduces the ESR and eosinophil counts.
(v) Reduces the intensity of bronchial attack.
(vi) It is completely safe.
It is to be noted that the formulation of the present invention is susceptible to modifications, adaptations and changes by those skilled in the art. Such variant formulations are intended to be within the scope of the present invention which is further set forth under the following claims:




WE CLAIM:
1. A herbal composition for the treatment of Bronchial Asthma comprising of 5 to 6% by weight of Alsi seeds Linum usitatissimum linn, 12 to 14% by weight of Methi seeds Trigonella foenum-graecum linn, 25 to 27% by weight of Seer fruits Allium sativum Linn, 43 to 45% by weight of chilbeenj seeds Strychnos potatorum, 5 to 6% by weight of Meghz-c-karanj kernal pongamia glabra vent, 5 to 6% by weight of Meghz-e-Karanjwa kernel Coesalpinia bonducella flem, garlic and purified water in the ratio of 1:3 to 1:3.5 and honey and all herbs in the ratio by weight of 2:1 to 2:1.5, and 0.15% sodium benzoate as preservative.
2. A herbal composition for the treatment of Bronchial Asthma as claimed in claim 1 wherein the process for preparation of the composition comprises of:-

a) hot extraction of garlic in purified water by heating at 100-105°C,
b) concentrating the said extract of garlic by heating again,

c) passing it through activated charcoal,
d) heating honey at 55°C to bring it into molten state, mixing with garlic extract of step (b) and heating to concentrate the mixture to 80%,
e) mixing the finely grinded powder of herbs followed by addition of preservative.
3. A herbal composition for the treatment of bronchial Asthma and process for preparation thereof as substantially described and illustrated herein.




Documents:

582-del-2003-abstract.pdf

582-del-2003-claims.pdf

582-del-2003-complete specification (granted).pdf

582-del-2003-correspondence-others.pdf

582-del-2003-correspondence-po.pdf

582-del-2003-description (complete).pdf

582-del-2003-form-1.pdf

582-del-2003-form-13.pdf

582-del-2003-form-18.pdf

582-del-2003-form-2.pdf

582-del-2003-form-3.pdf

582-del-2003-gpa.pdf

582-del-2003-pa.pdf

582-del-2003-petition-138.pdf


Patent Number 244034
Indian Patent Application Number 582/DEL/2003
PG Journal Number 47/2010
Publication Date 19-Nov-2010
Grant Date 15-Nov-2010
Date of Filing 08-Apr-2003
Name of Patentee THE DIRECTOR, CENTRAL COUNCIL FOR RESEARCH IN UNANI MEDICINE
Applicant Address UNANI MEDICINE, 61-65, INSTITUTIONAL AREA, OPP. "D" BLOCK JANAKPURI, NEW DELHI-110058 INDIA
Inventors:
# Inventor's Name Inventor's Address
1 MOHAMMED YOUSUF REGIONAL RESEARCH INSTITUTE OF UNAMI MEDICINE, UNIVERSITY OF KASHMIR, SRINAGAR
2 SEEMA AKBAR REGIONAL RESEARCH INSTITUTE OF UNAMI MEDICINE, UNIVERSITY OF KASHMIR, SRINAGAR
3 IRFAT ARA REGIONAL RESEARCH INSTITUTE OF UNAMI MEDICINE, UNIVERSITY OF KASHMIR, SRINAGAR
4 KHALID MAHMOOD SIDDIQUI UNANI MEDICINE, 61-65, INSTITUTIONAL AREA, OPP. "D" BLOCK JANAKPURI, NEW DELHI-110058 INDIA
5 SUHAIL MUSTAFA ADHAMI UNANI MEDICINE, 61-65, INSTITUTIONAL AREA, OPP. "D" BLOCK JANAKPURI, NEW DELHI-110058 INDIA
6 SHAMSHAD AHMAD KHAN UNANI MEDICINE, 61-65, INSTITUTIONAL AREA, OPP. "D" BLOCK JANAKPURI, NEW DELHI-110058 INDIA
7 ANIS AHMAD ANSARI UNANI MEDICINE, 61-65, INSTITUTIONAL AREA, OPP. "D" BLOCK JANAKPURI, NEW DELHI-110058 INDIA
PCT International Classification Number A61K 35/78
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA