Title of Invention

A PROCESS FOR PREPARING ANTIHYPERGLICEMIC THIAZOLIDINEDIONE COMPOUND PIOGLITAZONE, ROSIGLITAZONE AND TROGLITAZONE

Abstract The present invention relates to a process for reducing an exocyclic double bond at the 5-position of a thiazolidinedione moiety of a thiazolidinedione precursor of antihyperglycemic compound pioglitazone, rosiglitazone and troglitazone comprising the steps of: a) preparing a solution or suspension of the said thiazolidinedione precursor in a non-ether solvent medium with a base, wherein the non-ether solvent medium comprises water or a mixture of water with one or more organic solvent, which comprises methanol, ethanol, isopropanol, ethyl acetate, toluene, xylene, methylene chloride, N,N-dimethylformamide, N,N-dimethylacetamide, or a mixture thereof, and the base, which comprises an alkaline or alkaline earth carbonate, an alkaline hydrogen carbonate, an organic secondary or tertiary amine or an amidine, b )combining obtained solution or suspension with a dithionite source, wherein the dithionite source comprises sodium-, lithium-, potassium-, calcium-, magnesium-, a tetraalkylammonium- or a guanidinium-dithionite.
Full Text

Documents:

1425-chenp-2006 complete specification as granted.pdf

1425-chenp-2006-abstract.pdf

1425-chenp-2006-claims.pdf

1425-chenp-2006-correspondnece-others.pdf

1425-chenp-2006-description(complete).pdf

1425-chenp-2006-form 1.pdf

1425-chenp-2006-form 3.pdf

1425-chenp-2006-form 5.pdf

1425-chenp-2006-pct.pdf


Patent Number 234567
Indian Patent Application Number 1425/CHENP/2006
PG Journal Number 29/2009
Publication Date 17-Jul-2009
Grant Date 08-Jun-2009
Date of Filing 26-Apr-2006
Name of Patentee SANDOZ AG
Applicant Address Lichtstrasse 35, CH-4056 Basel,
Inventors:
# Inventor's Name Inventor's Address
1 NAMBIAR, Sudhir 201, Cassia, Hiranandani Estate, Off Ghodbundar Road, Thane 400607,
2 PISE, Abhinay, Chandrakant Om Prarthana C H S, Near Shankar mandir, Vikramnagar, Kalwa, Thane 400605,
PCT International Classification Number C07D417/12
PCT International Application Number PCT/EP2004/012149
PCT International Filing date 2004-10-27
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 0325174.1 2003-10-28 U.K.