| Title of Invention | HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) |
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| Abstract | 5 Isolated human monoclonal antibodies which specifically bind to hum~ EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human 'monoclonal antibodies by undergoing V -D-J recombination and isotype switching. Also .10 disclosed are pharmaceutical compositions comprising the human antibodies, non- -human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |
| Full Text | HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |
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0070-chenp-2004 abstract duplicate.pdf
0070-chenp-2004 claims duplicate.pdf
0070-chenp-2004 descripition completed duplicate.pdf
0070-chenp-2004 drawings duplicate.pdf
070-chenp-2004-correspondnece-others.pdf
070-chenp-2004-correspondnece-po.pdf
070-chenp-2004-description(complete).pdf
| Patent Number | 229177 | |||||||||||||||
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| Indian Patent Application Number | 70/CHENP/2004 | |||||||||||||||
| PG Journal Number | 12/2009 | |||||||||||||||
| Publication Date | 20-Mar-2009 | |||||||||||||||
| Grant Date | 13-Feb-2009 | |||||||||||||||
| Date of Filing | 12-Jan-2004 | |||||||||||||||
| Name of Patentee | GENMAB A/S | |||||||||||||||
| Applicant Address | TOLDBODGADE 33, DK-1253 COPENHAGEN K, | |||||||||||||||
Inventors:
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| PCT International Classification Number | C07K 16/00 | |||||||||||||||
| PCT International Application Number | PCT/US02/18748 | |||||||||||||||
| PCT International Filing date | 2002-06-13 | |||||||||||||||
PCT Conventions:
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