Title of Invention

PYRIDAZINYL PHENYL HYDRAZONE COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME.

Abstract Therapeutically active compounds of formula (I) in which R1 to R4 means hydrogen, alkyl, alkenyl, aryl, arylalkyl, carboxyalkyl, hydroxyalkyl or halogenalkyl, or R2 and R3 form a ring of 5-7 carbon atoms, R5 to R9 means hydrogen, alkyl, alkenyl, aryl, arylalkyl, acyl, hydroxy, alkoxy, alkoxycarbonyl, amino, acylamino, alkylamino, aryloxy, halogen, cyano, nitro, carboxy, alkylsulfonyl, sulfonamido or trifluoromethyl, wherein each aryl residue defined above by itself or as a part of another group may be substituted, and pharmaceutically acceptable salts and esters thereof. The compounds increase the calcium sensitivity of contractile proteins of the cardiac muscle and are thus useful in the treatment of congestive heart failure.
Full Text

Documents:

IN-PCT-2002-1121-KOL-CORRESPONDENCE.pdf

IN-PCT-2002-1121-KOL-FORM 27.pdf

in-pct-2002-1121-kol-granted-abstract.pdf

in-pct-2002-1121-kol-granted-assignment.pdf

in-pct-2002-1121-kol-granted-claims.pdf

in-pct-2002-1121-kol-granted-correspondence.pdf

in-pct-2002-1121-kol-granted-description (complete).pdf

in-pct-2002-1121-kol-granted-examination report.pdf

in-pct-2002-1121-kol-granted-form 1.pdf

in-pct-2002-1121-kol-granted-form 18.pdf

in-pct-2002-1121-kol-granted-form 3.pdf

in-pct-2002-1121-kol-granted-form 5.pdf

in-pct-2002-1121-kol-granted-gpa.pdf

in-pct-2002-1121-kol-granted-letter patent.pdf

in-pct-2002-1121-kol-granted-reply to examination report.pdf

in-pct-2002-1121-kol-granted-specification.pdf

in-pct-2002-1121-kol-granted-translated copy of priority document.pdf


Patent Number 222462
Indian Patent Application Number IN/PCT/2002/1121/KOL
PG Journal Number 33/2008
Publication Date 15-Aug-2008
Grant Date 13-Aug-2008
Date of Filing 02-Sep-2002
Name of Patentee ORION CORPORATION
Applicant Address ORIONINTIE 1, FIN-02200 ESPOO,
Inventors:
# Inventor's Name Inventor's Address
1 PYSTYNEN JARMO II VISNIEMENTIE 6 A 5, FIN 02260 ESPOO,
2 PIPPURI AINO KAITAANPORTTI 4A, FIN 02360 ESPOO
3 LUIRO ANNE SIILITIE 6 C 14, FIN 00800 HELSINKI
4 NORE PENTII MALMINKATU 24 E 52, FIN 00100 HELSINKI
5 BACKSTROM REIJO POUTAMAENTIE 14 F 68, FIN 00360 HELSINKI
6 LONNBERG KARI MALMINMAENTIE 5 A 1, FIN 02280 ESPOO,
7 HAIKALA HEIMO SEILIMAKI 18 A 4, FIN 02180 ESPOO
8 LEVIJOKI JOUKO AIRPTIE 5 A, FIN 00830 HELSINKI
9 KAHEINEN PETRI TOPELIUKSENKATU 7 B 24, FIN 00250 HELSINKI,
10 KAIVOLA JUHA PTAVANTIE 4 A 11, FIN 00200 HELSINKI,
PCT International Classification Number C07D 237/04
PCT International Application Number PCT/FI0100241
PCT International Filing date 2001-03-12
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 20000577 2000-03-13 Finland