| Title of Invention | SUBSTITUTED ARYLALCANOIC ACID DERIVATIVES AS PPAR PAN AGONISTS WITH POTENTANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY |
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| Abstract | Disclosed is the preparation and pharmaceutical use of substituted arylalcanoic acid derivatives of Formula I, wherein ring A, ring B, Rl, R2, R3, R4, R5, X, Alkl, Alk2, Arl, and Ar2 are as defined in the specification. These compounds, as selective agonists activating peroxisome proliferator-activated receptors (PPAR), in particularly the RXR/PPARalpha, RXR/PPARgamma, and RXRJPPARdelta heterodimers, are useful in the treatment and/or prevention of type 2 diabetes and associated metabolic syndrome such as hypertension, obesity, insulin resistance, hyperlipidemia, hyperglycemia, hypercholesterolemia, atherosclerosis, coronary artery disease, and other cardiovascular disorders with improved side effects profile commonly associated with conventional PPARgamma agonists. |
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792-KOLNP-2005-CORRESPONDENCE.pdf
792-KOLNP-2005-FORM 27 1.1.pdf
792-kolnp-2005-granted-abstract.pdf
792-kolnp-2005-granted-assignment.pdf
792-kolnp-2005-granted-claims.pdf
792-kolnp-2005-granted-correspondence.pdf
792-kolnp-2005-granted-description (complete).pdf
792-kolnp-2005-granted-drawings.pdf
792-kolnp-2005-granted-examination report.pdf
792-kolnp-2005-granted-form 1.pdf
792-kolnp-2005-granted-form 18.pdf
792-kolnp-2005-granted-form 3.pdf
792-kolnp-2005-granted-form 5.pdf
792-kolnp-2005-granted-gpa.pdf
792-kolnp-2005-granted-letter patent.pdf
792-kolnp-2005-granted-specification.pdf
792-kolnp-2005-granted-translated copy of priority document.pdf
| Patent Number | 221582 | ||||||||||||||||||||||||||||||
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| Indian Patent Application Number | 792/KOLNP/2005 | ||||||||||||||||||||||||||||||
| PG Journal Number | 26/2008 | ||||||||||||||||||||||||||||||
| Publication Date | 27-Jun-2008 | ||||||||||||||||||||||||||||||
| Grant Date | 25-Jun-2008 | ||||||||||||||||||||||||||||||
| Date of Filing | 03-May-2005 | ||||||||||||||||||||||||||||||
| Name of Patentee | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. | ||||||||||||||||||||||||||||||
| Applicant Address | RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY, SUIT C301, P.O. BOX 28, HIGH-TECH INDUSTRIAL PARK, NANSHAN DISTRICT, SHENZHEN, GUANGDONG 518057 | ||||||||||||||||||||||||||||||
Inventors:
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| PCT International Classification Number | A61K 31/335 | ||||||||||||||||||||||||||||||
| PCT International Application Number | PCT/IB2003/005371 | ||||||||||||||||||||||||||||||
| PCT International Filing date | 2003-11-21 | ||||||||||||||||||||||||||||||
PCT Conventions:
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