| Title of Invention | PROAEROLYSIN CONTAINING PROTEASE ACTIVATION SEQUENCES AND METHODS OF USE FOR TREATMENT OF PROSTATE CANCER |
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| Abstract | Disclosed herein is modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, The proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed. (FIG. - 5) |
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379-kolnp-2004-granted-abstract.pdf
379-kolnp-2004-granted-assignment.pdf
379-kolnp-2004-granted-claims.pdf
379-kolnp-2004-granted-correspondence.pdf
379-kolnp-2004-granted-description (complete).pdf
379-kolnp-2004-granted-drawings.pdf
379-kolnp-2004-granted-form 1.pdf
379-kolnp-2004-granted-form 18.pdf
379-kolnp-2004-granted-form 3.pdf
379-kolnp-2004-granted-form 5.pdf
379-kolnp-2004-granted-gpa.pdf
379-kolnp-2004-granted-letter patent.pdf
379-kolnp-2004-granted-reply to examination report.pdf
379-kolnp-2004-granted-specification.pdf
| Patent Number | 217468 | ||||||||||||
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| Indian Patent Application Number | 00379/KOLNP/2004 | ||||||||||||
| PG Journal Number | 13/2008 | ||||||||||||
| Publication Date | 28-Mar-2008 | ||||||||||||
| Grant Date | 26-Mar-2008 | ||||||||||||
| Date of Filing | 22-Mar-2004 | ||||||||||||
| Name of Patentee | UNIVERSITY OF VICTORIA INNOVATION AND DEVELOPMENT CORPORATION AND JOHNS HOPKINS UNIVERSITY | ||||||||||||
| Applicant Address | P.O. BOX-3075, R-HUT, MCENZIE AVENUE VICTORIA BRITISH COLUMBIA CANADA | ||||||||||||
Inventors:
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| PCT International Classification Number | C07K | ||||||||||||
| PCT International Application Number | PCT/US02/27061 | ||||||||||||
| PCT International Filing date | 2002-08-23 | ||||||||||||
PCT Conventions:
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