Title of Invention | ACTIVE CATALYSTS FOR STEREOSELECTIVE RING-OPENING REACTIONS |
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Abstract | A method for making a chiral transition metal-ligand catalyst complex that is active in catalyzing stereoselective ring opening reactions includes contacting an asymmetric tetradentate ligand, in an excess of a Bronsted acid, with a salt of a first row transition metal, wherein the acidity of the conjugate acid of the salt is the same as or less than the acidity of the Bronsted acid, under conditions effective to allow formation of the active chiral transition metal-ligand catalyst complex, and forming a solution of the complex in a water-miscible, protic solvent from which the active complex can be precipitated by the addition of water and adding water to the solution to precipitate at least a portion of the complex. |
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Patent Number | 215376 | |||||||||||||||
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Indian Patent Application Number | 386/CHENP/2005 | |||||||||||||||
PG Journal Number | 13/2008 | |||||||||||||||
Publication Date | 31-Mar-2008 | |||||||||||||||
Grant Date | 26-Feb-2008 | |||||||||||||||
Date of Filing | 14-Mar-2005 | |||||||||||||||
Name of Patentee | RHODIA PHARMA SOLUTIONS INC | |||||||||||||||
Applicant Address | 259 Prospect Plains Road, Cranbury, New Jersey 08512, | |||||||||||||||
Inventors:
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PCT International Classification Number | B01J 31/18 | |||||||||||||||
PCT International Application Number | PCT/US03/25680 | |||||||||||||||
PCT International Filing date | 2003-08-18 | |||||||||||||||
PCT Conventions:
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