| Title of Invention | A METHOD FOR PREPARING A COMPOUND 6-ALKENYL-, 6-ALKENYL AND 6-EPOXY-EPOTHILONE DERIVATIVES |
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| Abstract | This invention describes the new 6-alkenyl- and 6-alkinyl- epothilone derivatives of general formula (I) in which R¹ª, R¹b, R²ª, R³ª, R³b, R⁴, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and/or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described. |
| Full Text | N/A |
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in-pct-2001-01305-mum-cancelled page(02-08-2005).pdf
in-pct-2001-01305-mum-cancelled pages(2-8-2007).pdf
in-pct-2001-01305-mum-claim(granted)-(02-08-2005).pdf
in-pct-2001-01305-mum-claims(complete)-(19-10-2001).pdf
in-pct-2001-01305-mum-claims(granted)-(02-08-2005).doc
in-pct-2001-01305-mum-claims(granted)-(7-2-2008).pdf
in-pct-2001-01305-mum-correspondence(02-08-2007).pdf
in-pct-2001-01305-mum-correspondence(ipo)-(09-08-2004).pdf
in-pct-2001-01305-mum-correspondence(ipo)-(31-3-2008).pdf
in-pct-2001-01305-mum-description(complete)-(19-10-2001).pdf
in-pct-2001-01305-mum-description(granted)-(7-2-2008).pdf
in-pct-2001-01305-mum-form 1(19-10-2001).pdf
in-pct-2001-01305-mum-form 13(02-08-2005).pdf
in-pct-2001-01305-mum-form 13(02-08-2007).pdf
in-pct-2001-01305-mum-form 19(27-04-2004).pdf
in-pct-2001-01305-mum-form 1a(02-08-2007).pdf
in-pct-2001-01305-mum-form 1a(19-10-2001).pdf
in-pct-2001-01305-mum-form 2(complete)-(19-10-2001).pdf
in-pct-2001-01305-mum-form 2(granted)-(02-08-2005).doc
in-pct-2001-01305-mum-form 2(granted)-(02-08-2005).pdf
in-pct-2001-01305-mum-form 2(granted)-(7-2-2008).pdf
in-pct-2001-01305-mum-form 2(title page)-(complete)-(19-10-2001).pdf
in-pct-2001-01305-mum-form 2(title page)-(granted)-(7-2-2008).pdf
in-pct-2001-01305-mum-form 3(11-08-2005).pdf
in-pct-2001-01305-mum-form 3(19-10-2001).pdf
in-pct-2001-01305-mum-form 5(19-10-2001).pdf
in-pct-2001-01305-mum-form-pct-isa-210(19-10-2001).pdf
in-pct-2001-01305-mum-power of authority(19-10-2001).pdf
in-pct-2001-01305-mum-power of authority(22-07-2005).pdf
in-pct-2001-01305-mum-specification(amended)-(2-8-2007).pdf
| Patent Number | 214190 | |||||||||||||||||||||
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| Indian Patent Application Number | IN/PCT/2001/01305/MUM | |||||||||||||||||||||
| PG Journal Number | 13/2008 | |||||||||||||||||||||
| Publication Date | 28-Mar-2008 | |||||||||||||||||||||
| Grant Date | 07-Feb-2008 | |||||||||||||||||||||
| Date of Filing | 19-Oct-2001 | |||||||||||||||||||||
| Name of Patentee | SCHERING AKTIENGESELLSCHAFT | |||||||||||||||||||||
| Applicant Address | D-13342 BERLIN, GERMANY | |||||||||||||||||||||
Inventors:
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| PCT International Classification Number | C07D 493/04 | |||||||||||||||||||||
| PCT International Application Number | PCT/IB00/00657 | |||||||||||||||||||||
| PCT International Filing date | 2000-05-01 | |||||||||||||||||||||
PCT Conventions:
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