Title of Invention

HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING

Abstract Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity $i(in vitro) and $i(in vivo). An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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Documents:

abstract1.jpg

in-pct-2001-01146-mum-claims(granted)-(12-11-2007).doc

in-pct-2001-01146-mum-claims(granted)-(12-11-2007).pdf

in-pct-2001-01146-mum-correspondence(26-09-2005).tif.pdf

IN-PCT-2001-01146-MUM-CORRESPONDENCE(26-5-2010).pdf

in-pct-2001-01146-mum-correspondence(ipo)-(23-01-2006).pdf

in-pct-2001-01146-mum-drawing(12-11-2007).pdf

in-pct-2001-01146-mum-form 1(28-09-2005).pdf

in-pct-2001-01146-mum-form 13(01-01-2008).pdf

in-pct-2001-01146-mum-form 13(23-02-2006).pdf

in-pct-2001-01146-mum-form 13(26-5-2010).pdf

in-pct-2001-01146-mum-form 19(17-05-2004).pdf

in-pct-2001-01146-mum-form 2(granted)-(12-11-2007).doc

in-pct-2001-01146-mum-form 2(granted)-(12-11-2007).pdf

in-pct-2001-01146-mum-form 24(01-03-2006).pdf

in-pct-2001-01146-mum-form 3(28-09-2005).pdf

in-pct-2001-01146-mum-form 4(23-02-2006).pdf

in-pct-2001-01146-mum-form 5(28-04-2005).pdf

in-pct-2001-01146-mum-form-pct-ipea-409(21-09-2001).pdf

in-pct-2001-01146-mum-form-pct-isa-210(12-11-2007).pdf

IN-PCT-2001-01146-MUM-OTHER DOCUMENT(26-5-2010).pdf

in-pct-2001-01146-mum-petition under rule 137(28-09-2005).pdf

in-pct-2001-01146-mum-power of attorney(26-05-2006).pdf

in-pct-2001-01146-mum-power of authority(26-05-2006).pdf


Patent Number 213389
Indian Patent Application Number IN/PCT/2001/01146/MUM
PG Journal Number 04/2008
Publication Date 25-Jan-2008
Grant Date 01-Jan-2008
Date of Filing 21-Sep-2001
Name of Patentee KNOLL GMBH
Applicant Address KNOLLSTRASSE 50, D-67061 LUDWIGSHAFEN,
Inventors:
# Inventor's Name Inventor's Address
1 DU FOU, SARAH 76 ICKLEFORD ROAD, HITCHEN, HERTFORDSHIRE SG5 1TL,
2 SALFELD, JOCHEN 177 OLD WESTBOROGH ROAD, NORTH GRAFTON, MA 01536,
3 ROGUSKA, MICHAEL 16 HILLDALE ROAD, ASHLAND, MA 01721,
4 PASKIND, MICHAEL 253 REDEMPTION ROCK TRAIL, STERLING, MA 01564,
5 BANERJEE, SUBHASHIS 25 HAPGOOD WAY, SHREWBURY, MA 01545,
6 TRACEY, DANIEL 149 SHAKER ROAD, HARVARD, MA 01451,
7 WHITE, MICHAEL 30 ANGELICA DRIVE, FRAMINGHAM, MA 01701,
8 KAYMAKCALAN, ZEHRA 4 PICADILLY WAY, WESTBOROUGH, MA 01581,
9 LABKOVSKY, BORIS 107A-5 BROADMEADOW ROAD, MARLBOROUGH, MA 01752,
10 SAKORAFAS, PAUL 47 COURT STREET, NEWTON, MA 02160,
11 FRIEDRICH, STUART 20 ALBION STREET, MELROSE, MA 02176,
12 MYLES, ANGELA APARTMENT #7, 11 CRESCENT DRIVE, ANDOVER, MA 01810,
13 VELDMAN, GEERTRUIDA 60 WOODMERE DRIVE, SUDBURY, MA 01776,
14 VENTURINI, AMY 207 WOBURN STREET, LEXINGTON, MA 02420,
15 WARNE, NICHOLAS 27 FARRWOOD DRIVE, ANDOVER, MA 01810,
16 WIDOM, ANGELA 19 CHEROKEE ROAD, ACTON, MA 01720,
17 EL VIN, JOHN 36 PEROWNE STREET, CAMBRIDGE, CB1 2AY,
18 DUNCAN, ALEXANDER 3 HAUWXTON ROAD, LITTLE SHELFORD, CAMBRIDGE CB2 5HJ,
19 DERBYSHIRE, ELAINE 15 THE BRAMBLES, STUDLANDS RISE, ROYSTON, HERTFORDSHIRE SG8 9NQ,
20 CARMEN, SARA 136 STURTON STREET, CAMBRIDGE CB1 2QF,
21 SMITH, STEPHEN 33 CHURCH ROAD, WICKEN, ELY, CAMBRIDGESHIRE, CB7 5XT,
22 HOLTET, THOR, LAS 13 MORTIMER ROAD, ROYSTON, HERTFORDSHIRE,
PCT International Classification Number C07K 16/24
PCT International Application Number PCT/US00/07946
PCT International Filing date 2000-03-24
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 60/126,603 1999-03-25 U.S.A.