Title of Invention

FUNGICIDAL MIXTURES

Abstract A novel method for increasing the supply ranges of packet oriented transferring radio stations which are located outside the range of a central base station and are supplied by wireless base stations (relay stations). In contrast to conventional wireless transfer systems, a communication service quality is guaranteed. The invention uses a common time-interconnected capacity assignment method. Said capacity assignment is generated by an AP for stations (MT, FMT) which can be reached directly by a base station (AP). Individual MTs are present in the form of wireless base stations and serve as relay stations (FMTs) with regard to the MTs outside the range of an AP. For an AP, FMTs appear as MTs. The FMT forms a partial frame structure in a part of the AP distribution capacity transfer system which is embedded in the time frame structure dictated by the commanding central station.
Full Text

Fungicidal mixtures
The present invention relates to a fungicidal mixture which comprises
a) (2RS,3SR)-l-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorphe-
nyl)propyl]-lH-l,2,4-tria2ole

or a salt or adduct thereof, and
b) tetrachloroisophthalonitrile II

in a synergistically active amount.
The invention furthermore relates to methods of controlling harmful fungi using mixtures of the compounds I and II and to the use of compound I and of the compound II for the preparation of such mixtures.
The compound of the formula I, its preparation and its action against harmful fungi are disclosed in EP-A 196 038 and "The Pesticide Manual", 10th Edition, The British Crop Protection Council and The Royal Society of Chemistry, 1994 - termed "Pesticide Manual" hereinbelow - Page 67: BAS 48 0 F, proposed common name: epoxiconazole)• The compound II (common name: chlorothalonil), its preparation and its action against harmful fungi is also known (of. "Pesticide Manual", Page 193).
With a view to reducing the rate of application and to improving the spectrum of action of the known compounds I and II, it is an object of the present invention to provide mixtures which have an

improved activity against harmful fungi while the total amount of active ingredients applied is reduced (synergistic mixtures),
Accordingly, we have found that this object is achieved by the mixture defined at the outset. Moreover, we have found that better control of the harmful fungi is possible by applying compound I and compound II simultaneously, together or separately, or by applying compound I and compound II in succession than when the individual compounds are used alone.
Due to the basic character of the 1,2,4-triazole ring group, the compound I is capable of forming salts or adducts with inorganic or organic acids or with metal ions *
Examples of inorganic acids are hydrohalic acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid and hydriodic acid, furthermore carbonic acid, sulfuric acid, phosphoric acid and nitric acid.
Suitable organic acids are, for example: formic acid and alkanoic acids, such as acetic acid, trifluoroacetic acid, trichloroacetic acid and propionic acid, and also glycolic acid, thiocyanic acid, lactic acid, succinic acid, citric acid, benzoic acid, cinnamic acid, oxalic acid, alkylsulfonic acids {sulfonic acids having straight-chain or branched alkyl radicals having 1 to 20 carbon atoms), arylsulfonic acids or aryldisulfonic acids (aromatic radicals such as phenyl and naphthyl which have attached to them one or two sulfo groups), alkylphosphonic acids (phosphonic acids having straight-chain or branched alkyl radicals of 1 to 20 carbon atoms), arylphosphonic acids or aryldiphosphonic acids (aromatic radicals such as phenyl and naphthyl which have attached to them one or two phosphoric acid radicals), it being possible for the alkyl or aryl radicals to have attached to them further substituents, eg. p-toluenesulfonic acid, salicylic acid, p-aminosalicylic acid, 2-phenoxyben2oic acid, 2-acetoxybenzoic acid etc.
Suitable metal ions are, in particular, the ions of the elements of the first to eighth sub-group, mainly chromium, manganese, iron, cobalt, nickel, copper, zinc, and also of the second main group, mainly calcium and magnesium, of the third and fourth main groups, in particular aluminum, tin and lead. The metals can exist in the various valencies which they can assume.
When preparing the mixtures, it is preferred to employ the pure active ingredients I and II, with which further active ingredients against harmful fungi or other pests such as insects,

arachnids or nematodes, or else herbicidal or growth-regulating active ingredients, or fertilizers, can be admixed, if so required.
The mixtures of the compounds I and II, or the simultaneous joint or separate use of the compounds I and II, have an outstanding action against a wide spectrum of phytopathogenic fungi, in particular from the classes of the Ascomycetes, Basidiomycetes, Phycomycetes and Deuteromycetes. Some of them act systemically and can therefore also be employed as foliar- and soil-acting fungicides.
They are especially important for controlling a large number of fungi in a variety of crop plants such as cotton, vegetable species (eg. cucumbers, beans and cucurbits), barley, grass, oats, coffee, corn, fruit species, rice, rye, soybean, grape vine, wheat, ornamentals, sugar cane and a variety of seeds.
They are particularly suitable for controlling the following phytopathogenic fungi: Erysiphe graminis (powdery mildew) on cereals, Erysiphe cichoracearum and sphaerotheca fuliginea on cucurbits, Podosphaera leucotricha on apples, Uncinula necator on grape vines, Puccinia species on cereals, Rhizoctonia species on cotton, rice and lawns, Ustilago species on cereals and sugar cane, Venturia inaequalis (scab) on apples, Helminthosporium species on cereals, Septoria nodorum on wheat, Botrytis cinerea (gray mold) on strawberries and grape vines, Cercospora arachidicola on groundnuts, Pseudocercosporella herpotrichoides on wheat and barley, Pyricularia oryzae on rice, Phytophthora infestans on potatoes and tomatoes, Plasmopara viticola on grape vines, Alternaria species on vegetables and fruit, and Fusarium and Verticillium species.
Furthermore, they can be used in the protection of materials (eg. in the protection of wood), for example against Paecilomyces variotii.
The compounds I and II can be applied simultaneously together or separately or in succession, with the order, in the case of separate application, generally not having any effect on the result of the control measures.
The compounds I and II are usually used in a weight ratio of 10:1 to 0.05:1, preferably 5:1 to 0,1:1, in particular 3:1 to 0.2:1.

The application rates of the mixtures according to the invention are, especially on agricultural land, from 0.01 to 3 kg/ha, preferably 0.1 to 1,5 kg/ha, in particular 0.1 to 1,0 kg/ha, depending on the nature of the desired effect. In the case of the compounds I, the application rates are from 0.01 to 0.5 kg/ha, preferably 0.05 to 0.5 kg/ha, in particular 0,05 to 0*4 kg/ha. Accordingly, in the case of the compounds II, the application rates are from 0.01 to 2 kg/ha, preferably 0.05 to 1 kg/ha, in particular 0.05 to 0.5 kg/ha.
For seed treatment, application rates of the mixture are generally from 0.001 to 50 g/kg of seed, preferably 0.01 to 10 g/kg, in particular 0.01 to 8 g/kg.
If phytopathogenic harmful fungi are to be controlled, the separate or joint application of the compounds I and II or of the mixtures of the compounds I and II is effected by spraying or dusting the seeds, the plants or the soils before or after sowing of the plants, or before or after plant emergence.
The fungicidal synergistic mixtures according to the invention^ or the compounds I and II, can be formulated for example in the form of ready-to-spray solutions, powders and suspensions or in the form of highly concentrated aqueous, oily or other suspensions, dispersions, emulsions, oil dispersions, pastes, dusts, materials for spreading or granules, and applied by spraying, atomizing, dusting, spreading or pouring. The use form depends on the intended purpose; in any case, it should guarantee as fine and uniform as possible a distribution of the mixture according to the invention.
The formulations are prepared in a manner known per se, eg. by adding solvents and/or carriers. It is usual to admix inert additives, such as emulsifiers or dispersants, with the formulations•
Suitable surfactants are the alkali metal salts, alkaline earth metal salts and ammonium salts of aromatic sulfonic acids, eg. ligno-, phenol-, naphthalene- and dibutylnaphthalenesulfonic acid, and of fatty acids, alkyl- and alkylarylsulfonates, alkyl, lauryl ether and fatty alcohol sulfates, and salts of sulfated hexa-, hepta- and octadecanols or of fatty alcohol glycol ethers, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene, or of the naphthalenesulfonic acids, with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctyl-, octyl-or nonylphenol, alkylphenyl polyglycol ethers, tributylphenyl

polyglycol ether, alkylaryl polyether alcohols, isotridecyl alcohol, fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers or polyoxypropylene alkyl ethers, lauryl alcohol polyglycol ether acetate, sorbitol esters, ligninsulfite waste liquors or methylcellulose.
Powders, materials for spreading and dusts can be prepared by mixing or jointly grinding the compounds I or II or the mixture of the compounds I and II with a solid carrier.
Granules (eg. coated granules, impregnated granules or homogeneous granules) are usually prepared by binding the active ingredient, or active ingredients, to a solid carrier.
Fillers or solid carriers are, for example, mineral earths, such as silicas, silica gels, silicates, talc, kaolin, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, and fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, and products of vegetable origin, such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders or other solid carriers.
The formulations generally comprise 0.1 to 95% by weight, preferably 0.5 to 90% by weight, of one of the compounds I and II or of the mixture of the compounds I and II. The active ingredients are employed in a purity of from 90% to 100%, preferably 95% to 100% (according to NMR or HPLC spectrum).
The compounds I and II, the mixtures, or the corresponding formulations, are applied by treating the harmful fungi, their environment, or the plants, seeds, soils, areas, materials or spaces to be kept free from them, with a fungicidally active amount of the mixture, or of the compounds I and II in the case of separate application.
Application can be effected before or after infection by the harmful fungi.
Use Excunple
Activity against Botrytis cinerea
The active ingredients, separately or together, were formulated as a 10% strength emulsion in a mixture of 70% by weight of cyclohexanone, 20% by weight of Nekanil® LN (Lutensol® AP6, wetting agent having emulsifying and dispersing action, based on

ethoxylated alkylphenols) and 10% by weight of Emulphor® EL (Emulan® EL, emulsifier based on ethoxylated fatty alcohols) and diluted with water to give the desired concentration.
Bell pepper seedlings cultivar "Neusiedler Ideal Elite" were grown until 4-5 leaves had developed properly and then sprayed to drip point with aqueous suspensions comprising 80 % by weight of active ingredient and 20 % by weight of emulsifier in the dry matter. After the spray coating had dried on, the plants were sprayed with a conidia suspension of the fungus Botrytis cinerea and placed into a chamber with high atmospheric humidity at 22 -24°C, After 5 days, the disease on the untreated control plants had developed to such an extent that the leaf necroses formed covered the majority of the leaves.
For evaluation, the visually determined values for the percentage of diseased leaf area was converted into (observed) efficacies as a % of the untreated control.
The theoretically expected efficacies of the mixtures of the active ingredients were determined using Colby's formula [R.S. Colby, Weeds 15., 20-22 (1967)] and compared with the observed efficacies.
Colby's formula:
E - X + y - x-y/100
E expected efficacy, expressed in % of the untreated control, when using the mixture of two active ingredients A and B at the concentrations a and b
X efficacy, expressed in % of the untreated control, when using active ingredient A at a concentration of a
y efficacy, expressed in % of the untreated control, when using active ingredient B at a concentration of b
An efficacy of 0 means that the infection level corresponds to the untreated control; an efficacy of 100 means an infection level of 0%.

Test results (untreated control: infection level 100 %)

*) calculated using Colby's formula
The test results show that the observed efficacy for all mixing ratios is higher than the efficacy calculated using Colby's formula.



We claim:
1. A fungicidal mixture comprising
a) (2RS,3SR)-1-[3-{2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)-
propyl]-lH-1,2,4-triazole

or a salt or adduct thereof, and
b) tetrachloroisophthalonitrile II

in a synergistically active amount,
2. A fungicidal mixture as claimed in claim 1, wherein the weight ratio of the compound I or a salt or adduct thereof to the compound II is 10:1 to 0.05:1.
3. A method of controlling harmful fungi, which comprises treating the harmful fungi, their environment, or the plants, seeds, soils, areas, materials or spaces to be kept free from them, with the compound of the formula I or a salt or adduct thereof as set forth in claim 1 and the compound of the formula II as set forth in claim 1.
4. A method as claimed in claim 3, wherein the compound I or a salt or adduct thereof as set forth in claim 1 and the compound II as set forth in claim 1 are applied simultaneously together or separately or in succession.

5. A method as claimed in claim 3 or 4, wherein the compound I or a salt or adduct thereof as set forth in claim 1 is applied in an amount of 0.01 to 0.5 kg/ha.
6. A method as claimed in claims 3 to 5, wherein 0.01 to 2 kg/ha of the compound II as set forth in claim 1 are applied.
7. The use of the compound I or a salt or adduct thereof as set forth in claim 1 for the preparation of a fungicidally active synergistic mixture as claimed in claim 1.
8. The use of the compound II as set forth in claim I for the preparation of a fungicidally active synergistic mixture as claimed in claim 1-
9. A fungicidal mixture substantially as herein described and exemplified.
10. A method of controlling harmful fungi substantially as herein described and exemplified.


Documents:

1547-mas-1996-abstract.pdf

1547-mas-1996-claims filed.pdf

1547-mas-1996-claims granted.pdf

1547-mas-1996-correspondnece-others.pdf

1547-mas-1996-correspondnece-po.pdf

1547-mas-1996-description(complete)filed.pdf

1547-mas-1996-description(complete)granted.pdf

1547-mas-1996-form 1.pdf

1547-mas-1996-form 26.pdf

1547-mas-1996-form 3.pdf

1547-mas-1996-form 5.pdf

1547-mas-1996-other documents.pdf


Patent Number 212178
Indian Patent Application Number 1547/MAS/1996
PG Journal Number 02/2008
Publication Date 11-Jan-2008
Grant Date 26-Nov-2007
Date of Filing 04-Sep-1996
Name of Patentee M/S. BASF AKTIENGESELLSCHAFT
Applicant Address 67056 LUDWIGSHAFEN,
Inventors:
# Inventor's Name Inventor's Address
1 MICHAEL REICHARDT 67056 LUDWIGSHAFEN,
PCT International Classification Number A 01 N 43 /653
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 195 33796.4 1995-09-13 Germany