Title of Invention

BICYCLIC HETEROCYCLES AND PROCESS FOR THE PREPARATION THEREOF

Abstract

Bicyclic heterocycles of general formula wherein Ra denotes a hydrogen atom, Ra denotes a phenyl, benzyl or 1-phenylethyl group, whilst the phenyl nucleus is substituted in each case by the radicals R1 and R2, whilst R1 and R2, which may be identical or different, each denotes a hydrogen, fluorine, chlorine or bromine atom, X denotes a nitrogen atom, A denotes an imino group, B denotes a carbonyl group, C denotes a 1, 2-vinylene, ethynylene or 1, 3-butadien-l, 4-ylene group, D denotes an C1-3 -alkylene group, E denotes a Di-(C1-4-alkyl)-arnino group, wherein the alkyl moieties may be identical or different, a methylamino or ethylamino group each substituted at the nitrogen atom by a 2-methoxy-ethyl, l-methoxy-2-propyl, 2-methoxy-propyl, 3-methoxy-propyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl, tetrahydrofuran-2-ylmethyl, 1 -methyl-piperidin-4-yl, 1 -ethyl-piperidin-4-yl, 1 -(tetrahydrofuran-3-yl)-piperidin-4-yl,cyclopropyl or cyclopropylmethyl group, a bis- (2-methoxyethyl) -amino group, a pyrrolidine, piperidino or morpholino group each optionally substituted by one or two methyl groups. a piperazino group substituted in 4-position by a methyl, ethyl, cyclopropyl, cyclopropylmethyl, 2-methoxy-ethyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl or Letrahydrofuran-2-ylmethyl group, a thiomorpholino, S-oxido-thiomorpholino or S, S-dioxidothiomorpholino group, a 2-(methoxymethyl)-pyrrolidino, 2-(ethoxymethyl)-pyrrolidino, 4-hydroxy-piperidino, 4-methoxy-piperidino, 4-ethoxy-piperidino, 4- (tetrahydrofuran-3-yl) -piperidino or 4-morpholino-piperidino group, and Rc denotes a cyclopropylmethoxy, cyclobutylmethoxy, cyclopentyloxy or cyclohexylmethoxy group, a cyclobutyloxy, cyclopentyloxy or cyclohexyloxy group, a tetrahydrofuran-3-yloxy, tetrahydropyran-4-yloxy or tetrarnydrofuran-2-ylmethoxy group, the tautomers, stereoisomers and salts thereof.

Full Text

FORM 2 THE PATENTS ACT 1970 [39 OF 1970] & The Patents Rule, 2003 COMPLETE SPECIFICATION [See Section 10 and Rule 13] "BICYCLIC HETEROCYCLES AND PROCESS FOR THE PREPARATION THEREOF" BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (formerly known as BOEHRINGER INGELHEIM PHARMA KG), a German company of Binger Strasse 173, D-55216 Ingelheim am Rhein, Germany, The following specification particularly describes the nature of the invention and the manner in which it is to be performed:- The present invention relates to bicyclic heterocycles and process for the preparation thereof. The present invention relates to bicyclic heterocycles of general formula the tautomers, the stereoisomers and the salts thereof, parti¬cularly the physiologically acceptable salts thereof with in¬organic or organic acids or bases which have valuable pharma¬cological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the prepara¬tion thereof. In the above general formula I Ra denotes a hydrogen atom or a C1-alkyl group, Ra denotes a phenyl, benzyl or 1-phenylethyl group wherein the phenyl nucleus is substituted in each case by the groups R1 to R3, whilst R1 and R2, which may be identical or different, in each case denote a hydrogen, fluorine, chlorine, bromine or iodine atom, a C1-alkyl, hydroxy, C1-alkoxy, C3.6-cycloalkyl, C4_6-cycloalkoxy, C2_5-alkenyl or C2.5-alkynyl group, an aryl, aryloxy, arylmethyl or arylmethoxy group, a C3.5-alkenyloxy or C3_5-alkynyloxy group, whilst the unsaturated moiety may not be linked to the oxygen atom, a C1-4alkylsulphenyl, C1-4-alkylsulphinyl, C1-4-alkylsul-phonyl, C1-4-alkylsulphonyloxy, trifluoromethylsulphenyl, trifluoromethylsulphinyl or trifluoromethylsulphonyl group, a methyl or methoxy group substituted by 1 to 3 fluorine atoms, an ethyl or ethoxy gtoup substituted by 1 to 5 fluorine atoms, a cyano or nitro group or an amino group optionally sub¬stituted by one or two C1-4-alkyl groups, wherein the substituents may be identical or different, or R1 together with R2, if they are bound to adjacent carbon atoms, denote a -CH=CH-CH=CH, -CH=CH-NH or -CH=N-NH group and R3 denotes a hydrogen, fluorine, chlorine or bromine atom, a C1-4-alkyl, trifluoromethyl or C1-4-alkoxy group, X denotes a methyne group substituted by a cyano group or a nitrogen atom, A denotes an imino group optionally substituted by a C1-4-alkyl group, B denotes a carbonyl or sulphonyl group, C denotes a 1, 3-allenylerie, 1,1- or 1,2-vinylene group which may be substituted in each case by one or two methyl groups or by a trifluoromethyl group, an ethynylene group or a 1,3-butadien-l,4-ylene group optionally substituted by 1 to 4 methyl groups or by a trifluoromethyl group, D denotes an alkylene, -CO-alkylene or -S02-alkylene group wherein the alkylene moiety in each case contains 1 to 8 car¬bon atoms and additionally 1 to 4 hydrogen atoms in the alky¬lene moiety may be replaced by fluorine atoms, whilst the lin¬king of the -CO-alkylene or -S02-alkylene group to the adjacent group C in each case must take place via the carbonyl or sulphonyl group, a -CO-0-alkylene, -CO-NR4-alkylene or -S02-NR4-alkylene group wherein the alkylene moiety in each case contains 1 to 8 car¬bon atoms, whilst the linking to the adjacent group C in each case must take place via the carbonyl or sulphonyl group, wherein R4 denotes a hydrogen atom or a C1-4-alkyl group, or, if D is bound to a carbon atom of the group E, it may also denote a bond or, if D is bound to a nitrogen atom of the group E, it may also denote a carbonyl ox sulphonyl group, E denotes an amino, C1-4-alkylamino or di-(C1-4-alkyl)-amino group wherein the alkyl moieties may be identical or diffe¬rent , a C2_4-alkylamino group wherein the alkyl moiety is substituted in p-, y- or 8-position with regard to the nitrogen atom of the amino group by the group R5, whilst R5 denotes a hydroxy, C1-4-alkoxy, amino, C1-4-alkylamino or di- (C1-4-alkyl)-amino group, a 4- to 7-membered alkyleneimino group optionally substitu¬ted by one or two methyl groups or a 6- to 7-membered alkyleneimino group optionally substitu¬ted by one or two methyl groups wherein in each case a me¬thylene group in position 4 is replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, imino or N- (C1-4-alkyl) -imino group, an N-(C1-4-alkyl)-N-(C2-4-alkyl)-amino group wherein the C2_4-alkyl moiety is substituted in β-, γ- or 5-position with regard to the nitrogen atom of the amino group by the group R5, whilst R5 is as hereinbefore defined, a di- (C2.4-alkyl) -amino group wherein the two C2-4-alkyl moieties are substituted in each case in β-; γ- or 5-position with re¬gard to the nitrogen atom of the amino group by the group R5, whilst the substituents may be identical or different and R5 is as hereinbefore defined,- a C3-7-cycloalkylamino or C3-7-cycloalkyl-C1-3-alkylamino group wherein in each case the nitrogen atom may be substituted by a further C1-alkyl group, an amino or C1-4-alkylamino group wherein in each case the ni¬trogen atom is substituted by a tetrahydrofuran-3-yl, tetrahy-dropyran-3-yl, tetrahydropyran-4-yl, tetrahydrofuranylmethyl, 1-(tetrahydrofuran-3-yl)-piperidin-4-yl, 1-(tetrahydropyran-3-yl)-piperidin-4-yl, 1-(tetrahydropyran-4-yl)-piperidin-4-yl, 3-pyrrolidinyl, 3-piperidinyl, 4-piperidinyl, 3-hexahydro-azepinyl or 4-hexahydro-azepinyl group optionally substituted by 1 to 3 C1-4-alkyl groups, a 4- to 7-membered alkyleneimino group optionally substituted by 1 to 4 C1-2-alkyl groups, which may be substituted by the group R5 either at a cyclic carbon atom or at one of the alkyl groups, whilst R5 is as hereinbefore defined, a piperidino group substituted by a tetrahydrofuranyl, tetra-hydropyranyl or tetrahydrofuranylmethyl group, a 6- to 7-membered alkyleneimino group optionally substituted by 1 or 2 C1-2-alkyl groups wherein a methylene group in each case is replaced in the 4 position by an oxygen or sulphur atom, by an imino group substituted by the group R6, or by a sulphinyl or sulphonyl group, whilst R6 denotes a hydrogen atom, a C1-4-alkyl, 2-methoxy-ethyl, 3-methoxy-propyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydro-pyran-4-yl, tetrahydrosulphonyl, aminocarbonyl, C1-4-alkyl-aminocarbonyl or df uranylmethyl, formyl, C1-4 -alkyl -carbonyl, C1-4-alkyli- (C1-4-alkyl)-aminocarbonyl group, an imidazolyl group optionally substituted by 1 to 3 methyl groups, a C5-7-cycloalkyl group wherein a methylene group is replaced by an oxygen or sulphur atom, by an imino group substituted by the group R6, by a sulphinyl or sulphonyl group, whilst R6 is as hereinbefore defined, or D together with E denotes a hydrogen, fluorine or chlorine atom, a C1-4-alkyl group optionally substituted by 1 to 5 fluorine atoms, a C3-6-cycloalkyl group, an aryl, heteroaryl, C1-4-alkylcarbonyl or arylcarbonyl group, a carboxy, C1-4-alkoxycarbonyl, aminocarbonyl, C1-4-alkylamino-carbonyl or di- (C1-4-alkyl)-aminocarbonyl group or a carbonyl which is substituted by a 4- to 7-membered alky-leneimino group, whilst in the abovementioned 6- to 7-membered alkyleneimino groups in each case a methylene group may be re¬placed in the 4 position by an oxygen or sulphur atom, by an imino group substituted by the group R6, by a sulphinyl or sulphonyl group, whilst R6 is as hereinbefore defined, and Rc denotes a C4-7-cycloalkoxy or C3-7-cycloalkyl-C1-6-alkoxy group wherein the cycloalkyl moiety in each case may be substituted by a C1-3-alkyl, hydroxy, C1-4-alkoxy, amino, C1-4-alkylamino, di-(C1-4-alkyl)-amino, pyrrolidino, piperidino, morpholino, pipera-zino, N- (C1-4-alkyl) -piperazino, hydroxy-C1-4-alkyl, C1-4-alkoxy-C1-2-alkyl, amino-C1-2-alkyl, C1-4-alkylamino-C1-4-alkyl, di-(C1-4-alkyl) -amino-C1-4-alkyl, pyrrolidino-C1-4-alkyl, piperidino-C1-4-alkyl, morpholino-C1-4-alkyl, piperazino-C1-4-alkyl or N- (C1-2-alkyl) -piperazino-C1.2-alkyl group, whilst the above-mentioned monosubstituted cycloalkyl moieties may additionally be substituted by a C1-4-alkyl group, a tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetra-hydropyran-4-yloxy or tetrahydrofuranylmethoxy group, an C2-4-alkoxy group substituted in the β~, γ- or 5-position with regard to the oxygen atom by an azetidin-1-yl, 4-methyl-homopiperazino or 4-ethyl-homopiperazino group, a 3-pyrrolidinyloxy, 2-pyrrolidinyl-C1-4-alkyloxy, 3-pyrro-lidinyl-C1-4-alkyloxy, 3-piperidinyloxy, 4-piperidinyloxy, 2-piperidinyl-C1-4-alkyloxy, 3-piperidinyl-C1-4-alkyloxy, 4-piperidinyl-C1-4-alkyloxy, 3-hexahydro-azepinyloxy, 4-hexa-hydro-azepinyloxy, 2-hexahydro-azepinyl-C1_4-alkyloxy, 3-hexahydro-azepinyl-C1-4-alkyloxy or 4-hexahydro-azepinyl-C1-4-alkyloxy group wherein in each case the cyclic nitrogen atom is substituted by the group R6, where R6 is as hereinbefore defined, particularly those compounds of general formula I wherein Ra, Rb, A to C and X are as hereinbefore defined, (definition of E as in claim 1 of the priority text) E denotes an amino, C1-4-alkylamino or di-(C1-4-alkyl)-amino group wherein the alkyl moieties may be identical or different, a C2-4-alkylamino group wherein the alkyl moiety is substituted from position 2 by the group R5, whilst Rs denotes a hydroxy, C1-4-alkoxy, amino, C1-4-alkylamino or di- (C1-4-alkyl) -amino group, a 4- to 7-membered alkyleneimino group optionally substitu¬ted by one or two methyl groups or a 6- to 7-membered alkyleneimino group optionally substitu¬ted by one or two methyl groups wherein in each case a methylene group in position 4 is replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, imino or N- (C1-4-alkyl) -imino group, an N- (C1-4-alkyl) -N- (C2-4-alkyl) -amino group wherein the C2-4-alkyl moiety is substituted from position 2 onwards by the group R5, where R5 is as hereinbefore defined, a di- (C2_4-alkyl) -amino group wherein the two C2-4-alkyl moieties are substituted in each case from position 2 onwards by the group R5, whilst the substituents may be identical or different and R5 is as hereinbefore defined, a C3_7-cycloalkylamino or C3-7-cycloalkyl-C1-3-alkylamino group wherein in each case the nitrogen atom may be substituted by a further C1-4-alkyl group, an amino or C1-4-alkylamino group wherein in each case the nitrogen atom is substituted by a 3-pyrrolidinyl, 3-piperidinyl, 4-piperidinyl, 3-hexahydro-azepinyl or 4-hexahydro-azepinyl group optionally substituted by 1 to 3 C1-4-alkyl groups, a 4- to 7-membered alkyleneimino group optionally substituted by 1 to 4 C1-2-alkyl groups, which may be substituted by the group R5 either at a cyclic carbon atom or at one of the alkyl groups, whilst R5 is as hereinbefore defined, or a 6- to 7-membered alkyleneimino group optionally substituted by 1 or 2 C1-2-alkyl groups wherein a methylene group in each case is replaced in the 4 position by an oxygen or sulphur atom, by an imino group substituted by the group R6, or by a sulphinyl or sulphonyl group, whilst R6 denotes a hydrogen atom, a C1-4-alkyl, C3_7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, formyl, C1-4-alkylcarbonyl, C1-4-alkylsulphonyl, aminocarbonyl, C1-4-alkylaminocarbonyl or di- (C1-4-alkyl) -aminocarbonyl group, an imidazolyl group optionally substituted by 1 to 3 methyl groups, a C5-7-cycloalkyl group wherein a methylene group is replaced by an oxygen or sulphur atom, by an imino group substituted by the group R6, or by a sulphinyl or sulphonyl group, whilst R6 is as hereinbefore defined, or D together with E denotes a hydrogen, fluorine or chlorine atom, a C1-4-alkyl group optionally substituted by 1 to 5 fluorine atoms, a C3-6-cycloalkyl group, an aryl, heteroaryl, C1-4-alkylcarbonyl or arylcarbonyl group, a carboxy, C1-4-alkoxycarbonyl, aminocarbonyl, C1-4-alkylamino-carbonyl or di- (C1-4-alkyl)-aminocarbonyl group or a carbonyl which is substituted by a 4- to 7-membered alkyleneimino group, whilst in the abovementioned 6- to 7-membered alkyleneimino groups a methylene group may in each case be replaced in the 4 position by an oxygen or sulphur atom, by an imino group substituted by the group R6, by a sulphinyl or sulphonyl group, whilst R6 is as hereinbefore defined, and Rc denotes a C4-7-cycloalkoxy or C3-7-cycloalkyl-C1-6-alkoxy group wherein the cycloalkyl moiety in each case may be substituted by a C1-3-alkyl, hydroxy, C1-4-alkoxy, amino, C1-4-alkylamino, di- (C1-4-alkyl) -amino, pyrrolidino, piperidino, morpholino, piperazino, N- (C1-2-alkyl)-piperazino, hydroxy-C1-2-alkyl, C1-4-alkoxy-C1-2-alkyl, amino-C1-2-alkyl, C1-4-alkylamino-C1-2-alkyl, di- (C1-4-alkyl) -amino-C1-2-alkyl, pyrrolidino-C1-2-alkyl, piperi-dino-C1-2-alkyl, morpholino-C1-2-alkyl, piperazino-C1-2-alkyl or N-(C1-2-alkyl)-piperazino-C1-2-alkyl group, whilst the above-mentioned monosubstituted cycloalkyl moieties may additionally be substituted by a C1-3-alkyl group, or a 3-pyrrolidinyloxy, 2-pyrrolidinyl-C1_4-alkyloxy, 3-pyrrolidinyl-C1-4-alkyloxy, 3-piperidinyloxy, 4-piperidinyloxy, 2-piperidinyl-C1_4-alkyloxy, 3-piperidinyl-C1-4-alkyloxy, 4-piperidinyl-C1_4-alkyloxy, 3-hexahydro-azepinyloxy, 4-hexahydro-azepinyloxy, 2-hexahydro-azepinyl-C1-4-alkyloxy, 3-hexahydro-azepinyl-C1-4-alkyloxy or 4-hexahydro-azepinyl-C1-4-alkyloxy group wherein in each case the cyclic nitrogen atom is substituted by the group R6, where R6 is as hereinbefore defined. By the aryl moieties mentioned in the definition of the above-mentioned groups is meant a phenyl group which in each case may be monosubstituted by R7, mono-, di- or trisubstituted by R8 or monosubstituted by R7 and additionally mono- or disub-stituted by R8, wherein the substituents may be identical or different and R7 denotes a cyano, carboxy, C1-4-alkoxycarbonyl, aminocar-bonyl, C1-4-alkylaminocarbonyl, di-(C1-4-alkyl)-aminocarbonyl, C1-4-alkylsulphenyl, C1-4-alkylsulphinyl, C1-4-alkylsulphonyl, hydroxy, C1-4-alkylsulphonyloxy, trifluoromethyloxy, nitro, amino, C1-4-alkylamino, di- (C1-4-alkyl) -amino, C1-4-alkyl-carbonylamino, N- (C1-4-alkyl) -C1-4-alkylcarbonylamino, C1-4-alkylsulphonylamino, N- (Cl-4-alkyl) -C1-4-alkylsulphonylamino, aminosulphonyl, C1-4-alkylaminosulphonyl or di- (C1-4-alkyl) -aminosulphonyl group or a carbonyl group which is substituted by a 5- to 7-membered alkyleneimino group, whilst in the abovementioned 6- to 7-membered alkyleneimino groups in each case a methylene group in the 4 position may be replaced by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, imino or N-(C1-4-alkyl)-imino group, and R8 denotes a fluorine, chlorine, bromine or iodine atom, a C1-4-alkyl, trifluoromethyl or C1-4-alkoxy group or two groups R8, if they are bound to adjacent carbon atoms, together denote a C3_5-alkylene, methylenedioxy or 1,3-buta-dien-1,4-ylene group. The heteroaryl groups mentioned in the definition of the abovementioned groups also include a 5-membered heteroaromatic group which contains an imino group, an oxygen or sulphur atom or an imino group, an oxygen or sulphur atom and one or two nitrogen atoms, or a 6-membered heteroaromatic group which contains one, two or three nitrogen atoms, whilst the abovementioned 5-membered heteroaromatic groups may be substituted in each case by 1 or 2 methyl or ethyl groups and the abovementioned 6-membered heteroaromatic groups may be substituted in each case by 1 or 2 methyl or ethyl groups or by a fluorine, chlorine, bromine or iodine atom or by a trifluoromethyl, hydroxy, methoxy or ethoxy group. Preferred compounds of the above general formula I are those wherein Ra denotes a hydrogen atom, Rb denotes a phenyl, benzyl or 1-phenylethyl group wherein the phenyl nucleus is substituted in each case by the groups R1 to R3, whilst R1 and R2, which may be identical or different, in each case denote a hydrogen, fluorine, chlorine, bromine or iodine atom, a C1-4-alkyl, hydroxy, C1-4-alkoxy, C3_6-cycloalkyl, C4-6-cycloalkoxy, C2_5-alkenyl or C2-5-alkynyl group, an aryl, aryloxy, arylmethyl or arylmethoxy group, a methyl or methoxy group substituted by 1 to 3 fluorine atoms, a cyano or nitro group and R3 denotes a hydrogen, fluorine, chlorine or bromine atom, a C1-4-alkyl, trifluoromethyl or C1-4-alkoxy group, X denotes a methyne group substituted by a cyano group or a nitrogen atom, A denotes an imino group, B denotes a carbonyl or sulphonyl group, C denotes a 1,3-allenylene, 1,1- or 1,2-vinylene group, an ethynylene or 1,3-butadien-l,4-ylene group, D denotes an alkylene, -CO-alkylene or -S02-alkylene group wherein the alkylene moiety in each case contains 1 to 4 carbon atoms and additionally 1 to 4 hydrogen atoms in the alkylene moiety may be replaced by fluorine atoms, whilst the linking of the -CO-alkylene or -S02-alkylene group to the adjacent group C in each case must take place via the carbonyl or sulphonyl group, a -CO-0-alkylene, -CO-NR4-alkylene or -S02-NR4-alkylene group wherein the alkylene moiety in each case contains 1 to 4 carbon atoms, whilst the linking to the adjacent group C in each case must take place via the carbonyl or sulphonyl group, wherein R4 denotes a hydrogen atom or a C1-4-alkyl group, or, if D is bound to a carbon atom of the group E, it may also denote a bond, or, if D is bound to a nitrogen atom of the group E, it may also denote a carbonyl or sulphonyl group, E denotes a di- (C1-4-alkyl) -amino group wherein the alkyl moieties may be identical or different, an N- (C1-4-alkyl) -N-,(C2_4-alkyl) -amino group wherein the C2-4-alkyl moiety is substituted in the β-, γ- or 8-position with regard to the nitrogen atom of the amino group by the group R5, where R5 denotes a hydroxy, C1-4-alkoxy or di- (C1-4-alkyl) -amino group, a 4- to 7-membered alkyleneimino group optionally substituted by one or two methyl groups or a 6- to 7-membered alkyleneimino group optionally substituted by one or two methyl groups wherein in each case a methylene group in position 4 is replaced by an oxygen or sulphur atom, or by a sulphinyl, sulphonyl or N- (C1-4-alkyl) -imino group, a di- (C2-4-alkyl) -amino group wherein the two C2-4-alkyl moieties in each case are substituted in the β~, y- or 8-position with regard to the nitrogen atom of the amino group by the group R5, wherein the substituents may be identical or different and R5 is as hereinbefore defined, a C3_7-cycloalkylamino or C3_7-cycloalkyl-C1.3-alkylamino group wherein in each case the nitrogen atom is substituted by a further C1-4-alkyl group, a C1-4-alkylamino group wherein the nitrogen atom is substituted by a tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydro-pyran-4-yl, tetrahydrofuranylmethyl, 1-(tetrahydrofuran-3-yl)-piperidin-4-yl, 1-(tetrahydropyran-3-yl)-piperidin-4-yl, 1- (tetrahydropyran-4-yl) -piperidin-4-yl, N- (C1-2-alkyl) -3-pyrrolidinyl, N- (C1-2-alkyl) -3-piperidinyl, N-(C1-2-alkyl) -4-piperidinyl, N-(C1-2-alkyl)-3-hexahydro-azepinyl or N- (C1-2-alkyl) -4-hexahydro-azepinyl group, a 4- to 7-membered alkyleneimino group optionally substituted by 1 to 4 methyl groups, which may be substituted either at a cyclic carbon atom or at one of the methyl groups by the group R5, where R5 is as hereinbefore defined, a piperidino group substituted by a tetrahydrofuranyl, tetra-hydropyranyl or tetrahydrofuranylmethyl group, a 6- to 7-membered alkyleneimino group optionally substituted by 1 or 2 methyl groups wherein in each case a methylene group is replaced in the 4 position by an oxygen or sulphur atom, by an imino group substituted by the group R6 or by a sulphinyl or sulphonyl group, whilst R6 denotes a C1-4-alkyl, 2-methoxy-ethyl, 3-methoxy-propyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, tetra¬hydrofuranylmethyl, formyl, C1-4-alkylcarbonyl, C1-4-alkyl-sulphonyl, aminocarbonyl, C1-4-alkylaminocarbonyl or di- (C1-4-alkyl)-aminocarbonyl group, a C5-7-cycloalkyl group wherein a methylene group is replaced by an oxygen or sulphur atom, by an imino group substituted by the group R6, or by a sulphinyl or sulphonyl group, where R6 is as hereinbefore defined, or D together with E denotes a hydrogen, fluorine or chlorine atom, a C1-4-alkyl group optionally substituted by 1 to 5 fluorine atoms, a C3-6-cycloalkyl group, an aryl, C1-4-alkylcarbonyl or arylcarbonyl group, a carboxy, C1-4-alkoxycarbonyl, aminocarbonyl, C1-4-alkyl-aminocarbonyl or di- (C1-4-alkyl)-aminocarbonyl group or a carbonyl group which is substituted by a 4- to 7-membered alkyleneimino group, whilst in the abovementioned 6- to 7-membered alkyleneimino groups in each case a methylene group in the 4 position may be replaced by an oxygen or sulphur atom, by an imino group substituted by the group R6, or by a sulphinyl or sulphonyl group, where R6 is as hereinbefore defined, and Rc denotes a C4_7-cycloalkoxy or C3_7-cycloalkyl-C1_6-alkoxy group wherein the cycloalkyl moiety in each case may be substituted by a C1-3-alkyl, hydroxy, C1_4-alkoxy, di-(C1-4-alkyl)-amino, pyrrolidino, piperidino, morpholino, N-(C^-alkyl)-piperazino, hydroxy-C1-2-alkyl, C1-4-alkoxy-C1-2-alkyl, di- (C1-4-alkyl) -amino-C1-2-alkyl, pyrrolidino-C1-2-alkyl, piperidino-C1-2-alkyl, morpholino-C1-2-alkyl or N- (C1-2-alkyl) -piperazino-C1-2-alkyl group, whilst the abovementioned monosubstituted cycloalkyl moieties may additionally be substituted by a C1-3-alkyl group, a tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetra-hydropyran-4-yloxy or tetrahydrofuranylmethoxy group, an C2-4-alkoxy group substituted in the (3-, y- or 5-position with regard to the oxygen atom by an azetidin-1-yl, 4-methyl-homopiperazino or 4-ethyl-homopiperazino group, a 3-pyrrolidinyloxy, 2-pyrrolidinyl-C1-4-alkyloxy, 3-pyrrol idinyl-C1-4-alkyloxy, 3-piper idinyloxy, 4-piperidinyloxy, S-piperidinyl-C1-4-alkyloxy, 3-piperidinyl-C1-4-alkyloxy, 4-piperidinyl-C1-4-alkyloxy, 3-hexahydro-azepinyloxy, 4-hexahydro-azepinyloxy, 2-hexahydro-azepinyl-C1-4-alkyloxy, 3-hexahydro-azepinyl-C1-4-alkyloxy or 4-hexahydro-azepinyl-C1-4-alkyloxy group wherein in each case the cyclic nitrogen atom is substituted by the group R6, where R6 is as hereinbefore defined, whilst by the aryl moieties mentioned in the definition of the above-mentioned groups is meant a phenyl group which may in each case be monosubstituted by R7, mono-, di- or trisubstituted by R8 or monosubstituted by R7 and additionally mono- or disubsti-tuted by R8, wherein the substituents may be identical or different and R7 denotes a cyano, carboxy, C1-4-alkoxycarbonyl, aminocar-bonyl, C1-4-alkylaminocarbonyl, di- (C1-4-alkyl) -aminocarbonyl, C1-4-alkylsulphenyl, C1-4-alkylsulphinyl, C1-4-alkylsulphonyl, hydroxy, C1-4-alkylsulphonyloxy, trifluoromethyloxy, nitro, amino, C1-4-alkylamino, di- (C1-4-alkyl) -amino, C1-4-alkyl-carbonylamino, N- (C1-4-alkyl) -C1-4-alkylcarbonylamino, C1-4-alkylsulphonylamino, N- (C1-4-alkyl) -C1-4-alkylsulphonylamino, aminosulphonyl, C1-4-alkylaminosulphonyl or di-(C1-4-alkyl)-aminosulphonyl group or a carbonyl group which is substituted by a 5- to 7-membered alkyleneimino group, whilst in the abovementioned 6- to 7-membered alkyleneimino groups in each case a methylene group may be replaced in the 4 position by an oxygen or sulphur atom, by a sulphinyl, sulphonyl, imino or N- (C1-4-alkyl) -imino group, and R8 denotes a fluorine, chlorine, bromine or iodine atom, a C1-4-alkyl, trifluoromethyl or C1-4-alkoxy group or two groups RB, if they are bound to adjacent carbon atoms, together denote a C3_5-alkylene, methylenedioxy or 1,3-buta-dien-1,4-ylene group, the tautomers, stereoisomers and salts thereof. Particularly preferred compounds of the above general formula I are those wherein Ra denotes a hydrogen atom, Rb denotes a phenyl, benzyl or 1-phenylethyl group wherein the phenyl nucleus is substituted in each case by the groups Rx and R2, where R1 and R2, which may be identical or different, in each case denote a hydrogen, fluorine, chlorine or bromine atom, a methyl, trifluoromethyl or methoxy group, X denotes a nitrogen atom, A denotes an imino group, B denotes a carbonyl group, C denotes a 1,2-vinylene group, an ethynylene or 1,3-butadien-l,4-ylene group, D denotes a C1-4-alkylene group, or, if D is bound to a carbon atom of the group E, it may also denote a bond, or, if D is bound to a nitrogen atom of the group E, it may also denote a carbonyl group, E denotes a di- (C1-4-alkyl)-amino group wherein the alkyl moieties may be identical or different, an N- (C1-4-alkyl) -N- (C2-4-alkyl) -amino group wherein the C2-4-alkyl moiety is substituted in the β~, y- or 8-position with regard to the nitrogen atom of the amino group by the group R5, whilst R5 denotes a hydroxy, C1-3-alkoxy or di- (C1-3-alkyl) -amino group, a pyrrolidine, piperidino or morpholino group, a di- (C2-4-alkyl) -amino group wherein the two C2_4-alkyl moieties in each case are substituted in the β~, y- or 8-position with regard to the nitrogen atom of the amino group by the group R5, wherein the substituents may be identical or different and R5 is as hereinbefore defined, an C1-4-alkylamino group substituted at the nitrogen atom by a tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, tetrahydrofuranylmethyl, 1-(C1-2-alkyl)-pyrrolidin-3-yl, 1- (C1-2-alkyl)-piperidin-3-yl, l- (c1-2-alkyl)-piperidin-4-yl, 1-(tetrahydrofuran-3-yl)-piperidin-4-yl, 1-(tetrahydropyran-3-yl)-piperidin-4-yl or 1-(tetrahydropyran-4-yl)-piperidin-4-yl group, a C3-5-cycloalkylamino or C3-5-cycloalkyl-C1-3-alkylamino group wherein in each case the nitrogen atom is substituted by a further C1-3-alkyl group, a 5- to 7-membered alkyleneimino group optionally substituted by 1 or 2 methyl groups which may be substituted either at a cyclic carbon atom or at one or the methyl groups by the group R5, where R5 is as hereinbefore defined, or a piperidino group substituted by a tetrahydrofuranyl, tetra-hydropyranyl or tetrahydrofuranylmethyl group, a piperidino group optionally substituted by 1 or 2 methyl groups wherein the methylene group is replaced in the 4 posi¬tion by an oxygen or sulphur atom, by sulphinyl or sulphonyl group or by an imino group substituted by the group R6, whilst R6 denotes a C1-3-alkyl, 2-methoxy-ethyl, 3-methoxy-propyl, C3_6-cycloalkyl, , C3-6-cycloalkyl-C1-3-alkyl, tetrahydrofuran-3-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, tetra¬hydrofuranylmethyl, C1-3-alkylcarbonyl, C1-3-alkylsulphonyl, aminocarbonyl, C1-3-alkylaminocarbonyl or di-(C1-3-alkyl)-aminocarbonyl group, or D together with E denotes a hydrogen atom, a C1-3-alkyl group, an aryl or C1-4-alkylcarbonyl group or a C1-4-alkoxycarbonyl group, Rc denotes a C4-7-cycloalkoxy or C3-7-cycloalkyl-C1-4-alkoxy group wherein the cycloalkyl moiety in each case may be substituted by a C1-3-alkyl or C1-3-alkoxy group, a tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy, tetra-hydropyran-4-yloxy or tetrahydrofuranylmethoxy group, an C2-4-alkoxy group substituted in the p-, y- or 5-position with regard to the oxygen atom by an azetidin-1-yl, 4-methyl-homopiperazino or 4-ethyl-homopiperazino group, a 3-pyrrolidinyloxy, 2-pyrrolidinyl-C1-3-alkyloxy, 3-pyrrol idinyl-C1-3-alkyloxy, 3-piperidinyloxy, 4-piperidinyloxy, 2-piperidinyl-C1-3-alkyloxy, 3-piperidinyl- C1-3-alkyloxy, 4-piperidinyl-C1-3-alkyloxy, 3-hexahydro-azepinyloxy, 4-hexahydro-azepinyloxy, 2-hexahydro-azepinyl-C1-3-alkyloxy, 3-hexahydro-azepinyl-C1-3-alkyloxy or 4-hexahydro-azepinyl-C1-3-alkyloxy group wherein in each case the cyclic nitrogen atom is substituted by a methyl or ethyl group, whilst by the aryl moieties mentioned in the definition of the above-mentioned groups is meant a phenyl group which may be mono-, di- or trisubstitutad by R8, wherein the substituents may be identical or different and R8 denotes a fluorine, chlorine, bromine or iodine atom, a C1-4-alkyl, trifluoromethyl or C1-4-alkoxy group, the tautomers, stereoisomers and salts thereof. Most particularly preferred compounds of the above general formula I are those wherein Ra denotes a hydrogen atom, Rb denotes a phenyl, benzyl or 1-phenylethyl group, whilst the phenyl nucleus is substituted in each case by the radicals R2 and R2, whilst Rx and R2, which may be identical or different, each denote a hydrogen, fluorine, chlorine or bromine atom, X denotes a nitrogen atom, A denotes an imino group, B denotes a carbonyl group, C denotes a 1,2-vinylene, ethynylene or 1,3-butadien-l,4-ylene group, D denotes an C1-3-alkylene group, E denotes a Di- (C1-4-alkyl)-amino group, wherein the alkyl moieties may be identical or different, a methylamino or ethylamino group each substituted at the nitrogen atom by a 2-methoxy-ethyl, 1-methoxy-2-propyl, 2-methoxy-propyl, 3-methoxy-propyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl, tetrahydrofuran-2-ylmethyl, 1-methyl-piperidin-4-yl, l-ethyl-piperidin-4-yl, 1-(tetrahydrofuran-3-yl)-piperidin-4-yl, cyclopropyl or cyclopropylmethyl group, a bis-(2-methoxyethyl)-amino group, a pyrrolidine, piperidino or morpholino group each optionally substituted by one or two methyl groups, a piperazino group substituted in 4-position by a methyl, ethyl, cyclopropyl, cyclopropylmethyl, 2-methoxy-ethyl, tetra-hydrofuran-3-yl, tetrahydropyran-4-yl or tetrahydrofuran-2-ylmethyl group, a thiomorpholino, S-oxido-thiomorpholino or S,S-dioxido-thio-morpholino group, a 2-(methoxymethyl)-pyrrolidine, 2-(ethoxymethyl)-pyrrolidine, 4-hydroxy-piperidino, 4-methoxy-piperidino, 4-ethoxy-piperidino, 4-(tetrahydrofuran-3-yl)-piperidino or 4-morpholino-piperidino group or D together with E denote a hydrogen atom, a methyl, phenyl, methoxycarbonyl or ethoxycarbonyl group and Rc denotes a cyclopropylmethoxy, cyclobutylmethoxy, cyclopen-tylmethoxy or cyclohexylmethoxy group, a cyclobutyloxy, cyclopentyloxy or cyclohexyloxy group, a tetrahydrofuran-3-yloxy, tetrahydropyran-4-yloxy or tetrahy-drofuran-2-ylmethoxy group, a straight chained C2-4-alkoxy group terminally substituted by an azetidin-1-yl, 4-methyl-homopiperazino or 4-ethyl-homopiperazino group, a l-methyl-piperidin-4-yloxy or l-ethyl-piperidin-4-yloxy group, a (l-methyl-piperidin-4-yl)-C1-3-alkyloxy or (1-ethyl-piperidin-4-yl)-C1-2-alkyloxy group, especially those compounds wherein Ra denotes a hydrogen atom, Rb denotes a 1-phenylethyl group or a phenyl group wherein the phenyl nucleus is substituted by the radicals R1 and R2, whilst R1 and R2, which may be identical or different, each denote a hydrogen, fluorine, chlorine or bromine atom, X denotes a nitrogen atom, A denotes an imino group, B denotes a carbonyl group, C denotes a 1,2-vinylene, ethynylene or 1,3-butadien-l,4-ylene group, D denotes a methylene group, E denotes a dimethylamino, diethylamino, Bis-(2-methoxy-ethyl)-amino, N-methyl-N-(2-methoxy-ethyl)-amino, N-ethyl-N-(2-methoxy-ethyl)-amino, N-methyl-N-cyclopropyl-amino, N-methyl-N-cyclopropylmethyl-amino, N-methyl-N-(1-methoxy-2-propyl)-amino, N-methyl-N-(2-methoxy-propyl)-amino, N-methyl-N-(3-methoxy-propyl)-amino-, N-methyl-N-(tetra-hydrofuran-3-yl)-amino, N-methyl-N-(tetrahydropyran-4-yl)-amino, N-methyl-N-(tetrahydrofuran-2-ylmethyl)-amino or N-methyl-N-(l-methyl-piperidin-4-yl)-amino group, a pyrrolidino, piperidino or morpholino group each optionally substituted by one or two methyl groups, a piperazino group substituted in 4-position by a methyl, ethyl, cyclopropylmethyl or 2-methoxy-ethyl group, a S-oxido-thiomorpholino group, a 2-(methoxy-methyl)-pyrrolidino, 4-hydroxy-piperidino or 4-methoxy-piperidino group or D together with E denote a hydrogen atom, a methyl, phenyl or ethoxycarbonyl group, and Rc denotes a cyclopropylmethoxy, cyclobutyloxy or cyclopentyl-oxy group, a tetrahydrofuran-3-yloxy, tetrahydropyran-4-yloxy or tetra-hydrofuran-2-ylmethoxy group, a straight chained C2-4-alkoxy group terminally substituted by an azetidin-1-yl or 4-methyl-homopiperazino group, a 1-methyl-piperidin-4-yloxy group or a (l-methyl-piperidin-4-yl) -C1-3-alkyloxy group, the tautomers, stereoisomers and salts thereof. The following particularly valuable compounds of general for¬mula I may be mentioned by way of example: (a) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(1-methyl-pipe-ridin-4-yl)propyloxy]-6-[(vinylcarbonyl)amino]-quinazoline, (b) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-diethyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quina-zoline and (c) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(morpholin-4-yl) l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline as well as the salts thereof. The compounds of general formula I may be prepared, for exam¬ple, by the following processes: a) reacting a compound of general formula A-H , (II) wherein Ra to Rc, A and X are as hereinbefore defined, with a compound of general formula Z1-B-C-D-E ,(III) wherein B to E are as hereinbefore defined and Z1 denotes a leaving group such as a halogen atom, e.g. a chlorine or bromine atom, or a hydroxy group. The reaction is optionally carried out in a solvent or mixture of solvents such as methylene chloride, dimethylformamide, benzene, toluene, chlorobenzene, tetrahydrofuran, benzene/-tetrahydrofuran or dioxane optionally in the presence of an inorganic or organic base and optionally in the presence of a dehydrating agent, expediently at temperatures between -50 and 150°C, preferably at temperatures between -20 and 80°C. With a compound of general formula III wherein Z1 denotes a leaving group, the reaction is optionally carried out in a solvent or mixture of solvents such as methylene chloride, dimethylformamide, benzene, toluene, chlorobenzene, tetrahydrofuran, benzene/tetrahydrofuran or dioxane conveniently in the presence of a tertiary organic base such as triethylamine, pyridine or 2-dimethylaminopyridine, in the presence of N-ethyl-diisopropylamine (Hiinig base) , whilst these organic bases may simultaneously also act as solvent, or in the presence of an inorganic base such as sodium carbonate, potassium carbonate or sodium hydroxide solution expediently at temperatures between -50 and 150°C, preferably at temperatures between -20 and 80°C. With a compound of general formula III wherein Z1 denotes a hydroxy group, the reaction is preferably carried out in the presence of a dehydrating agent, e.g. in the presence of iso-butyl chloroformate, thionyl chloride, trimethyl chlorosilane, phosphorus trichloride, phosphorus pentoxide, hexamethyl-disilazane, N,N'-dicyclohexylcarbodiimide, N,N'-dicyclohexylcarbodiimide/N-hydroxysuccinimide or 1-hydroxy-benzotriazole and optionally also in the presence of 4-dimethylamino-pyridine, N,N'-carbonyldiimidazole or triphenylphosphine/carbon tetrachloride, expediently in a solvent such as methylene chloride, tetrahydrofuran, dioxane, toluene, chlorobenzene, dimethylsulphoxide, ethylene glycol monomethylether, ethyleneglycol, diethylether or sulpholane and optionally in the presence of a reaction accelerator such as 4-dimethylaminopyridine at temperatures between -50 and 150°C, but preferably at temperatures between -20 and 80°C. b) In order to prepare compounds of general formula I wherein the group E is linked to the group D via a nitrogen atom: reacting a compound of general formula A-B-C-D-Z2 , (IV) Rc wherein Ra to Rc, A to D and X are as hereinbefore defined and Z2 denotes a leaving group such as a halogen atom, a substituted hydroxy or sulphonyloxy group such as a chlorine or bromine atom, a methanesulphonyloxy or p-toluenesulphonyloxy group, with a compound of general formula H - E' , (V) wherein E" denotes one of the groups mentioned for E hereinbefore, which is linked to the group D via a nitrogen atom. The reaction is expediently carried out in a solvent such as isopropanol, butanol, tetrahydrofuran, dioxane, toluene, chlorobenzene, dimethylformamide, dimethylsulphoxide, methylene chloride, ethylene glycol monomethylether, ethylene glycol diethylether or sulpholane, optionally in the presence of an inorganic or tertiary organic base, e.g. sodium carbonate or potassium hydroxide, a tertiary organic base, e.g. triethylamine, or in the presence of N-ethyl-diisopropylamine (Hiinig base) , whilst these organic bases may simultaneously also serve as solvent, and optionally in the presence of a reaction accelerator such as an alkali metal halide at temperatures between -20 and 150°C, but preferably at temperatures between -10 and 100°C. The reaction may, however, also be carried out without a solvent or in an excess of the compound of general formula V used. If according to the, invention a compound of general formula I is obtained which contains an amino, alkylamino or imino group, this may be converted by acylation or sulphonylation into a corresponding acyl or sulphonyl compound of general formula I or if a compound of general formula I is obtained which contains an amino, alkylamino or imino group, this may be converted by alkylation or reductive alkylation into a corresponding alkyl compound of general formula I or if a compound of general formula I is obtained which contains a carboxy or hydroxyphosphoryl group, this may be converted by esterification into a corresponding ester of general formula I or if a compound of general formula I is obtained which contains a carboxy or ester group, this may be converted by reaction with an amine into a corresponding amide of general formula I. The subsequent esterification is optionally carried out in a solvent or mixture of solvents such as methylene chloride, dimethylformamide, benzene, toluene, chlorobenzene, tetrahydrofuran, benzene/tetrahydrofuran or dioxan or most advantageously in a corresponding alcohol, optionally in the presence of an acid such as hydrochloric acid or in the presence of a dehydrating agent, e.g. in the presence of isobutyl chloroformate, thionylchloride, trimethylchlorosilane, sulphuric acid, methanesulphonic acid, p-toluenesulphonic acid, phosphorus trichloride, phosphorus pentoxide, N,N'-dicyclohexylcarbodiimide, N,N'-dicyclohexylcarbodiimide/N-hydroxysuccinimide or 1-hydroxy-benzotriazole and optionally additionally in the presence of 4-dimethylamino-pyridine, N,N'-carbonyldiimidazole or triphenylphosphine/carbon tetrachloride, conveniently at temperatures between 0 and 150°C, preferably at temperatures between 0 and 80°C. The subsequent ester formation may also be carried out by reacting a compound which contains a carboxy or hydroxyphos-phoryl group with a corresponding alkyl halide. The subsequent acylation or sulphonylation is conveniently carried out in a solvent or mixture of solvents such as methylene chloride, dimethylformamide, benzene, toluene, chlorobenzene, tetrahydrofuran, benzene/tetrahydrofuran or dioxane with a corresponding acyl or sulphonyl derivative optionally in the presence of a tertiary organic base or in the presence of an inorganic base or in the presence of a dehydrating agent, e.g. in the presence of isobutyl chloroformate, thionyl chloride, trimethylchlorosilane, sulphuric acid, methanesulphonic acid, p-toluenesulphonic acid, phosphorus trichloride, phosphorus pentoxide, N,N'-dicyclohexyl carbodiimide, N,N'-dicyclohexyl carbodiimide/N-hydroxysuccinimide or 1-hydroxy-benzotriazole and optionally also in the presence of 4-dimethylamino-pyridine, N,N'-carbonyldiimidazole or triphenylphosphine/carbon tetrachloride, expediently at temperatures between 0 and 150°C, preferably at temperatures between 0 and 80°C. The subsequent alkylation is optionally carried out in a solvent or mixture of solvents such as methylene chloride, dimethylformamide, benzene, toluene, chlorobenzene, tetrahydrofuran, benzene/tetrahydrofuran or dioxane with an alkylating agent such as a corresponding halide or sulphonic acid ester, e.g. with methyl iodide, ethyl bromide, dimethyl sulphate or benzyl chloride, optionally in the presence of a tertiary organic base or in the presence of an inorganic base, expediently at temperatures between 0 and 150°C, preferably at temperatures between 0 and 100°C. The subsequent reductive alkylation is carried out with a corresponding carbonyl compound such as formaldehyde, acetaldehyde, propipnaldehyde, acetone or butyraldehyde in the presence of a complex metal hydride such as sodium borohydride, lithium borohydride, sodium triacetoxyborohydride or sodium cyanoborohydride, expediently at a pH of 6-7 and at ambient temperature or in the presence of a hydration cata¬lyst, e.g. with hydrogen in the presence of palladium/charcoal, at a hydrogen pressure of 1 to 5 bar. The methylation can also be carried out in the presence of formic acid as reduction agent at elevated temperatures, e.g. at temperatures between 60 and 120°C. The subsequent amide formation is carried out by reacting a corresponding reactive carboxylic acid derivative with a corresponding amine, optionally in a solvent or mixture of solvents such as methylene chloride, dimethylformamide, benzene, toluene, chlorobenzene, tetrahydrofuran, benzene/tetrahydrofuran or dioxane, whilst the amine used may simultaneously serve as solvent, optionally in the presence of a tertiary organic base or in the presence of an inorganic base or with a corresponding carboxylic acid in the presence of a dehydrating agent, e.g. in the presence of isobutyl chloroformate, thionyl chloride, trimethylchlorosilane, phosphorus trichloride, phosphorus pentoxide, N,N'-dicyclohexylcarbodiimide, N,N'-dicyclohexylcarbodiimide/N-hydroxysuccinimide or 1-hydroxy-benzotriazole and optionally also in the presence of 4-dimethylamino-pyridine, N,N'-carbonyldiimidazole or triphenylphosphine/carbon tetrachloride, expediently at temperatures between 0 and 150°C, preferably at temperatures between 0 and 80°C. In the reactions described hereinbefore, any reactive groups present such as hydroxy, carboxy, phosphono, O-alkyl-phosphono, amino, alkylamino or imino groups may be protected during the reaction by conventional protecting groups which are cleaved again after the reaction. For example, a protecting group for a hydroxy group may be a trimethylsilyl, acetyl, benzoyl, methyl, ethyl, tert.butyl, trityl, benzyl or tetrahydropyranyl group, protecting groups for a carboxy group may be a trimethylsilyl, methyl, ethyl, tert.butyl, benzyl or tetrahydropyranyl group, protecting groups for a phosphono group may be an alkyl group such as the methyl, ethyl, isopropyl or n-butyl group, the phenyl or benzyl group, and protecting groups for an amino, alkylamino or imino group may be a formyl, acetyl, trifluoroacetyl, ethoxycarbonyl, tert.-butoxycarbonyl, benzyloxycarbonyl, benzyl, methoxybenzyl or 2,4-dimethoxybenzyl group and additionally, for the amino group, a phthalyl group. Any protecting group used is optionally subsequently cleaved for example by hydrolysis in an aqueous solvent, e.g. in water, isopropanol/water, acetic acid/water, tetrahydrofuran/water or dioxan/water, in the presence of an acid such as trifluoroacetic acid, hydrochloric acid or sulphuric acid or in the presence of an alkali metal base such as sodium hydroxide or potassium hydroxide or aprotically, e.g. in the presence of iodotrimethylsilane, at temperatures between 0 and 120°C, preferably at temperatures between 10 and 100°C. However, a benzyl, methoxybenzyl or benzyloxycarbonyl group is cleaved, for example hydrogenolytically, e.g. with hydrogen in the presence of a catalyst such as palladium/charcoal in a suitable solvent such as methanol, ethanol, ethyl acetate or glacial acetic acid, optionally with the addition of an acid such as hydrochloric acid at temperatures between 0 and 100°C, but preferably at temperatures between 20 and 60°C, and at a hydrogen pressure of 1 to 7 bar, but preferably 3 to 5 bar. A 2,4-dimethoxybenzyl group, however, is preferably cleaved in trifluoroacetic acid in the presence of anisole. A tert.butyl or tert.butyloxycarbonyl group is preferably cleaved by treating with an acid such as trifluoroacetic acid or hydrochloric acid or by treating with iodotrimethylsilane optionally using a solvent such as methylene chloride, dioxan, methanol or diethyl ether. A trifluoroacetyl group is preferably cleaved by treating with an acid such as hydrochloric acid, optionally in the presence of a solvent such as acetic acid at temperatures between 50 and 120°C or by treating with sodium hydroxide solution optionally in the presence of a solvent such as tetrahydrofuran at tempe¬ratures between 0 and 50°C. A phthalyl group is preferably cleaved in the presence of hydrazine or a primary amine such as methylamine, ethylamine or n-butylamine in a solvent such as methanol, ethanol, isopropanol, toluene/water or dioxan at temperatures between 2 0 and 50°C. A single alkyl group may be cleaved from an O,O'-dialkylphos-phono group with sodium iodide, for example, in a solvent such as acetone, methylethylketone, acetonitrile or dimethylform-amide at temperatures between 40 and 150°C, but preferably at temperatures between 60 and 100°C. Both alkyl groups may be cleaved from an 0,0'-dialkyl-phos-phono group with iodotrimethylsilane, bromotrimethylsilane or chlorotrimethylsilane/sodium iodide, for example, in a solvent such as methyl chloride, chloroform or acetonitrile at tempe¬ratures between 0°C and the boiling temperature of the reac¬tion mixture, but preferably at temperatures between 20 and 60°C. Moreover, the compounds of general formula I obtained may be resolved into their, enantiomers and/or diastereomers, as mentioned hereinbefore. Thus, for example, cis/trans mixtures may be resolved into their cis and trans isomers, and compounds with at least one optically active carbon atom may be separated into their enantiomers. Thus, for example, the cis/trans mixtures may be resolved by chromatography into the cis and trans isomers thereof, the compounds of general formula I obtained which occur as racemates may be separated by methods known per se (cf. Allinger N. L. and Eliel E. L. in "Topics in Stereochemistry", Vol. 6, Wiley Interscience, 1971) into their optical antipodes and compounds of general formula I with at least 2 asymmetric carbon atoms may be resolved into their diastereomers on the basis of their physical-chemical differences using methods known per se, e.g. by chromatography and/or fractional crystallisation, and, if these compounds are obtained in racemic form, they may subsequently be resolved into the enantiomers as mentioned above. The enantiomers are preferably separated by column separation on chiral phases or by recrystallisation from an optically active solvent or by reacting with an optically active substance which forms salts or derivatives such as e.g. esters or amides with the racemic compound, particularly acids and the activated derivatives or alcohols thereof, and separating the diastereomeric mixture of salts or derivatives thus obtained, e.g. on the basis of their differences in solubility, whilst the free antipodes may be released from the pure diastereomeric salts or derivatives by the action of suitable agents. Optically active acids in common use are e.g. the D- and L-forms of tartaric acid or dibenzoyltartaric acid, di-o-tolyltartaric acid, malic acid, mandelic acid, camphorsulphonic acid, glutamic acid, aspartic acid or quinic acid. An optically active alcohol may be for example (+) or (-)-menthol and an optically active acyl group in amides, for example, may be a (+)-or (-)-menthyloxycarbonyl. Furthermore, the compounds of formula I may be converted into the salts thereof, particularly for pharmaceutical use into the physiologically acceptable salts with inorganic or organic acids. Acids which may be used for this purpose include for example hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, fumaric acid, succinic acid, lactic acid, citric acid, tartaric acid or maleic acid. Moreover, if the new compounds of formula I thus obtained con¬tain a carboxy, hydroxyphosphoryl, sulpho or 5-tetrazolyl group, they may subsequently, if desired, be converted into the salts thereof with inorganic or organic bases, particularly for pharmaceutical use into the physiologically acceptable salts thereof. Suitable bases for this purpose include for example sodium hydroxide, potassium hydroxide, arginine, cyclohexyl-amine, ethanolamine, diethanolamine and triethanolamine. The compounds of general formulae II to V used as starting materials are known from the literature in some cases or may be obtained by methods known from the literature (cf. Examples I to VII). For example, a starting compound of general formula I is ob¬tained by reacting a 7-fluoro-6-nitro compound correspondingly substituted in the 4 position with a corresponding alkoxide and subsequently reducing the nitro compound thus obtained or a starting compound of general formula IV is obtained by reac¬ting a 7-fluoro-6-nitro compound correspondingly substituted in the 4 position with a corresponding alkoxide, subsequently reducing the nitro compound thus obtained and then acylating with a corresponding compound. As already mentioned hereinbefore, the compounds of general formula I according to the invention and the physiologically acceptable salts thereof have valuable pharmacological pro¬perties, particularly an inhibiting effect on signal trans¬duction mediated by the Epidermal Growth Factor receptor (EGF-R), whilst this may be achieved for example by inhibiting ligand bonding, receptor dimerisation or tyrosine kinase it¬self. It is also possible to block the transmission of signals to components located further down. The biological properties of the new compounds were investi¬gated as follows: The inhibition of the EGF-R-mediated signal transmission can be demonstrated e.g. with cells which express human EGF-R and whose survival and proliferation depend on stimulation by EGF or TGF-alpha. A cell line of murine origin dependent on in-terleukin-3-(IL-3) which was genetically modified to express functional human EGF-R was used here. The proliferation of these cells known as F/L-HERc can therefore be stimulated either by murine IL-3 or by EGF (cf. von Riiden, T. et al. in EMBO J. 2, 2749-2756 (1988) and Pierce, J. H. et al. in Scien¬ce 23d, 628-631 (1988)). The starting material used for the F/L-HERc cells was the cell line FDC-P1, the production of which has been described by Dexter, T. M. et al. in J. Exp. Med. 152 1036-1047 (1980). Alternatively, however, other growth-factor-dependent cells may also be used (cf. for example Pierce, J. H. et al. in Science 219, 628-631 (1988), Shibuya, H. et al. in Cell 70, 57-67 (1992) and Alexander, W. S. et al. in EMBO J. 1SX, 3683- 3691 (1991)). For expressing the human EGF-R cDNA (cf. Ull¬rich, A. et al. in Nature 309-, 418-425 (1984)) recombinant retroviruses were used as described by von Riiden, T. et al. , EMBO J. 1, 2749-2756 (1988), except that the retroviral vector LXSN (cf. Miller, A. D. et al. in BioTechniques 1, 980-990 (1989)) was used for the expression of the EGF-R cDNA and the line GP+E86 (cf. Markowitz, D. et al. in J. Virol. £2, 1120-1124 (1988)) was used as the packaging cell. The test was performed as follows: F/L-HERc cells were cultivated in RPMl/1640 medium (Bio¬Whittaker) , supplemented with 10 % foetal calf serum (FCS, Boehringer Mannheim), 2 mM glutamine (BioWhittaker), standard antibiotics and 20 ng/ml of human EGF (Promega), at 37°C and 5% CO2. In order to investigate the inhibitory activity of the compounds according to the invention, 1.5 x 104 cells per well were cultivated in triplicate in 96-well dishes in the above medium (200 /zl) , the cell proliferation being stimulated with either EGF (20 ng/ml) or murine IL-3. The IL-3 used was obtai¬ned from culture supernatants of the cell line X63/0 mIL-3 (cf. Karasuyama, H. et al. in Eur. J. Immunol. 18., 97-104 (1988)). The compounds according to the invention were dis¬solved in 100% dimethylsulphoxide (DMSO) and added to the cul¬tures in various dilutions, the maximum DMSO concentration being 1%. The cultures were incubated for 48 hours at 37°C. In order to determine the inhibitory activity of the compounds according to the invention the relative cell number was mea¬sured in O.D. units using the Cell Titer 96™ AQueous Non-Ra¬dioactive Cell Proliferation Assay (Promega). The relative cell number was calculated as a percentage of the control (F/LHERc cells without inhibitor) and the concentration of active substance which inhibits the proliferation of the cells by 50% (IC50) was derived therefrom. The following results were obtained: Compound (Example No.) Inhibition of EGF-dependent proliferation IC50 [nM] 1 2(3) 0.35 1(7) 3 5 3(1) 0.2 The compounds of general formula I according to the invention thus inhibit signal transduction by tyrosine kinases, as de¬monstrated by the example of the human EGF receptor, and are therefore useful for treating pathophysiological processes caused by hyperfunction of tyrosine kinases. These are e.g. benign or malignant tumours, particularly tumours of epithe¬lial and neuroepithelial origin, metastasisation and the ab¬normal proliferation of vascular endothelial cells (neoangio-genesis). The compounds according to the invention are also useful for preventing and treating diseases of the airways and lungs which are accompanied by increased or altered production of mucus caused by stimulation by tyrosine kinases, e.g. in inflammatory diseases of the airways such as chronic bronchitis, chronic obstructive bronchitis, asthma, bronchiectasis, allergic or non-allergic rhinitis or sinusitis, cystic fibrosis, άl-antitrypsin deficiency, or coughs, pulmonary emphysema, pulmonary fibrosis and hyperreactive airways. The compounds are also suitable for treating diseases of the gastrointestinal tract and bile duct and gall bladder which are associated with disrupted activity of the tyrosine kinases, such as may be found e.g. in chronic inflammatory changes such as cholecystitis, Crohn's disease, ulcerative colitis, and ulcers in the gastrointestinal tract or such as may occur in diseases of the gastrointestinal tract which are associated with increased secretions, such as Menetrier's disease, secreting adenomas and protein loss syndrome. In addition, the compounds of general formula I and the physiologically acceptable salts thereof may be used to treat other diseases caused by abnormal function of tyrosine kinases, such as e.g. epidermal hyperproliferation (psoriasis), inflammatory processes, diseases of the immune system, hyperproliferation of haematopoietic cells, etc. By reason of their biological properties the compounds according to the invention may be used on their own or in conjunction with other pharmacologically active compounds, for example in tumour therapy, in monotherapy or in conjunction with other anti-tumour therapeutic agents, for example in combination with topoisomerase inhibitors (e.g. etoposide), mitosis inhibitors (e.g. vinblastine), compounds which interact with nucleic acids (e.g. cis-platin, cyclophosphamide, adriamycin), hormone antagonists (e.g. tamoxifen), inhibitors of metabolic processes (e.g. 5-FU etc.), cytokines (e.g. interferons), antibodies, etc. For treating respiratory tract diseases, these compounds may be used on their own or in conjunction with other therapeutic agents for the airways, such as substances with a secretolytic, broncholytic and/or antiinflammatory activity. For treating diseases in the region of the gastrointestinal tract, these compounds may also be administered on their own or in conjunction with substances having an effect on motility or secretion. These combinations may be administered either simultaneously or sequentially. These compounds may be administered either on their own or in conjunction with other active substances by intravenous, sub¬cutaneous, intramuscular, intraperitoneal or intranasal route, by inhalation or transdermally or orally, whilst aerosol for¬mulations are particularly suitable for inhalation. For pharmaceutical use the compounds according to the invention are generally used for warm-blooded vertebrates, particularly humans, in doses of 0.01-100 mg/kg of body weight, preferably 0.1-15 mg/kg. For administration they are formulated with one or more conventional inert carriers and/or diluents, e.g. with corn starch, lactose, glucose, microcrystalline cellulose, magnesium stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water, water/ethanol, water/glycerol, water/sorbitol, water/polyethylene -glycol, propylene glycol, stearyl alcohol, carboxymethylcellulose or fatty substances such as hard fat or suitable mixtures thereof in conventional galenic preparations such as plain or coated tablets, capsules, powders, suspen¬sions, solutions, sprays or suppositories. The following Examples are intended to illustrate the present invention without restricting it: Preparation of the starting compounds: Example 1 6-Amino-4-[(3-bromophenyl)amino]-7-[3-(1-methyl-piperidin- 4-yl)propylnxyl-qninaznlinp 1.00 g of 4-[(3-bromophenyl)amino]-7-[3-(1-methyl-piperidin-4-yl)propyloxy]-6-nitro-quinazoline is dissolved in 16 ml of water, 35 ml of ethanol and 1.3 ml of glacial acetic acid and heated to boiling. Then 54 0 mg of iron powder are added with stirring. The reaction mixture is refluxed for about another 35 minutes. For working up the cooled reaction mixture is diluted with 15 ml of ethanol, made alkaline with 15 N sodium hydroxide solution, combined with 20 g of Extrelute and stir¬red for about 20 minutes. The precipitate formed is suction filtered and washed with 200 ml of warm ethanol. The filtrate is concentrated by evaporation, mixed with about 3 0 ml of water and extracted 3 x with 70 ml of methylene chloride/me-thanol (9:1) each time. The combined extracts are dried over sodium sulphate and concentrated by evaporation, leaving a beige solid. Yield: 716 mg (76 % of theory), Melting point: 191-198°C Mass spectrum (ESI + ) : m/z = 470, 472 [M+H]+ The following compounds are obtained analogously to Example I: (1) 6-Amino-4-[(3-bromophenyl)amino]-7-[2-(1-methyl-piperidin- 4-yl)ethoxy]-quinazoline Melting point: 197°C Mass spectrum (ESI*) : m/z = 456, 458 [M+H]+ (2) 6-Amino-4-[(3-bromophenyl)amino]-7-[(1-methyl-piperidin- 4-yl)methoxy]-quinazoline Melting point: 207-208°C Mass spectrum (ESI*) : m/z = 442, 444 [M+H]+ (3) 6-Amino-4-[(3-bromophenyl)amino]-7-[(1-methyl-piperidin- 4-yl)oxy]-quinazoline Melting point: 170°C Mass spectrum (ESI*): m/z = 428, 430 [M+H]+ (4) 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-cyclopropyl- methoxy-quinazoline Melting point: 209°C R£ value: 0.68 (silica gel, ethyl acetate) (5) 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-cyclobutyl- oxy-quinazoline Rf value: 0.32 (silica gel, cyclohexane/ethyl acetate = 3:4) Mass spectrum (ESI+) : m/z = 359, 361 [M+H]+ (6) 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-cyclopentyl- oxy-quinazoline Rt value: 0.33 (silica gel, cyclohexane/ethyl acetate = 1:1) Mass spectrum (ESI + ) : m/z = 373, 375 [M+H]+ (14) 6-Amino-4-[(R)-(1-phenyl-ethyl)amino]-7-[2-(azetidin- 1-yl)-ethoxy]-quinazoline Rf value: 0.37 (silica gel, methylene chloride/methanol/concen- trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI + ) : m/z = 364 [M+H]+ (15) 6-Amino-4-[(R)-(1-phenyl-ethyl)amino]-7-[2-(4-methyl- perhydro-l,4-diazepin-l-yl)-ethoxy]-quinazoline Rf value: 0.10 (silica gel, methylene chloride/methanol/concen- trated aqueous ammonia solution = 90:10:1) Mass spectrum (ESI+) : m/z = 421 [M+H]+ (16) 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4- methyl-perhydro-1,4-diazepin-l-yl)-propyloxy]-quinazoline Rf value: 0.09 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI + ) : m/z = 459, 461 [M+H]+ (17) 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(azeti- din-l-yl)-propyloxy]-quinazoline Rf value: 0.11 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 402, 404 [M+H]+ Exampl p. II 4-[(3-Bromophenyl)amino]-7-[3-(1-methyl-piperidin-4-yl)propyl- oxyl -6-nitro-quinazoline To a solution of 1.45 g of 3-(l-methyl-piperidin-4-yl)-propan-l-ol in 40 ml of tetrahydrofuran are added 360 mg of sodium hydride. The white suspension formed is stirred for 15 minutes at 65°C, cooled and mixed with 1.45 g of 4-[(3-bromophenyl)-amino]-7-fluoro-6-nitro-quinazoline, whereupon the mixture suddenly turns dark red. The reaction mixture is stirred first for 10 minutes at ambient temperature, then for 45 minutes at 65°C. As the reaction is not yet complete, a further 150 mg of sodium hydride are added and the mixture is stirred for a fur¬ther 45 minutes at 65°C. The solvent is distilled off using a rotary evaporator and the brown residue is stirred with 50 ml of ice water. The aqueous phase is extracted with methylene chloride. The combined extracts are washed with water, dried over sodium sulphate and concentrated by evaporation. The crude product is purified by chromatography over a silica gel column with methylene chloride/methanol/concentrated ammonia solution (90:10:0.05). Yield: 1.30 g of (65 % of theory), Rf value: 0.28 (silica gel, methylene chloride/methanol/con¬centrated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI + ) : m/z = 500, 502 [M+H]+ The following compounds are prepared analogously to Example II: (1) 4-[(3-Bromophenyl)amino]-7-[2-(1-methyl-piperidin-4-yl)- ethoxy]-6-nitro-quinazoline Melting point: 152°C Mass spectrum (ESI + ) : m/z = 486, 488 [M+H]+ (2) 4-[(3-Bromophenyl)amino]-7-[(l-methyl-piperidin-4-yl)- methoxy]-6-nitro-quinazoline Melting point: 205-207°C Mass spectrum (ESI+) : m/z = 472, 474 [M+H]+ (3) 4- [ (3-Bromophenyl)amino]-7-[(1-methyl-piperidin-4-yl)oxy]- 6-nitro-quinazoline Melting point: 219°C Mass spectrum (ESI+) : m/z = 458, 460 [M+H]+ (4) 4-[(3-chloro-4-fluorophenyl)amino]-7-cyclopropylmethoxy- 6-nitro-quinazoline (carried out in dimethylformamide with potassium tert.butoxide as base) Melting point: 211-213°C Mass spectrum (ESI+) : m/z = 389, 391 [M+H]+ (5) 4-[(3-chloro-4-fluorophenyl)amino]-7-cyclobutyloxy-6- nitro-quinazoline (carried out in dimethylformamide with potassium tert.butoxide as base) Melting point: 235°C Rf value: 0.65 (silica gel, cyclohexane/ethyl acetate = 3:4) (6) 4-[(3-chloro-4-fluorophenyl)amino]-7-cyclopentyloxy-6- nitro-quinazoline (carried out in dimethylformamide with potassium tert.butoxide as base) Melting point: 230°C Mass spectrum (ESI+) : m/z = 403, 405 [M+H]+ (7) 4- [ (J?) - (1-Phenyl-ethyl) amino] -7-cyclobutyloxy-6-nitro- quinazoline (carried out in dimethylformamide with potassium tert.butoxide as base) Melting point: 108-110°C Rf value: 0.54 (silica gel, ethyl acetate) (8) 4-[{R)-(1-Phenyl-ethyl)amino]-7-cyclopropylmethoxy-6- nitro-quinazoline (carried out in dimethylformamide with potassium tert.butoxide as base) Melting point: 155°C Rf value: 0.24 (silica gel, cyclohexane/ethyl acetate = 1:1) (9) 4-[(R)-(1-Phenyl-ethyl)amino]-7-cyclopentyloxy-6-nitro- quinazoline (carried out in dimethylformamide with potassium tert.butoxide as base) Rf value: 0.24 (silica gel, petroleum ether/ethyl acetate = 1:1) Mass spectrum (ESI+) : m/z = 379 [M+H]+ (10) 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[3-(1- methyl-piperidin-4-yl)propyloxy]-quinazoline Rf value: 0.30 (silica gel, methylene chloride/methanol/concen- trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 474, 476 [M+H] + (11) 4-[(3-chloro-4-fluorophenyl)amino]-7-[(tetrahydrofuran- 2-yl)methoxy]-6-nitro-quinazoline (carried out in dimethyl- formamide with potassium tert.butoxide as base) Rf value: 0.47 (silica gel, ethyl acetate) Mass spectrum (ESI): m/z = 417, 419 [M-H] (12) 4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydro- furan-3-yl)oxy]-6-nitro-quinazoline (carried out in dimethyl-formamide with potassium tert.butoxide as base) Rf value: 0.45 (silica gel, ethyl acetate) Mass spectrum (ESI"): m/z = 403, 405 [M-H]" (13) 4-[(3-chloro-4-fluorophenyl)amino]-7-[(tetrahydropyran- 4-yl)oxy]-6-nitro-quinazoline (carried out in dimethylform- amide with potassium tert.butoxide as base) Rf value: 0.41 (silica gel, ethyl acetate) Mass spectrum (ESI"): m/z = 417, 419 [M-H]" (14) 4-[(R)-(1-Phenyl-ethyl)amino]-7-[2-(tetrahydropyran- 2-yloxy)-ethoxy]-6-nitro-quinazoline Rf value: 0.12 (silica gel, cyclohexane/ethyl acetate = 1:1) Mass spectrum (ESI+) : m/z = 439 [M+H]+ (15) 4-[(3-chloro-4-fluorophenyl)amino]-7-{3-[(tert.butyl- dimethylsilyl) oxy] -propyloxy} -6-nitro-quinazoline (carried out in dimethylformamide with potassium tert.butoxide as base) Rf value: 0.87 silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 507, 509 [M+H]+ Example III 4- [(R) - M -Pheny] -ethyl)aminol -6-nitro-7-f1uoro-quinazoline A solution of 74 ml of (R)-l-phenyl-ethylamine in 100 ml of dioxan is added dropwise to 108.8 g of 4-chloro-6-nitro-7-fluoro-quinazoline in 800 ml of methylene chloride with cooling. The reaction mixture is washed with water after stirring overnight at room temperature, the organic phase is separated, dried and evaporated. The residue obtained is purified by chromatography over a silica gel column (petroleum ether/ethyl acetate = 1:1). Yield: 52.9 g (35% of theory), Melting point: 203°C Mass spectrum (ESI + ) : m/z = 313 [M+H]+ Example IV 4-[(R)-(1-Phenyl-ethyl)amino]-7-[2-(azetidin-1-yl)-ethoxy]- 6-ni t.ro-quinazoline 221 mg of dried potassium carbonate and 50 mg of sodium iodide were added to 600 mg of 4- [ (R) - (1-phenyl-ethyl) amino] - 7-[2-methanesulphonyloxy-ethoxy]-6-nitro-quinazoline and 0.34 ml of azetidine in 5.0 ml of acetonitrile. The reaction mixture was heated to 70°C with stirring. Subsequently 3 ml of acetonitrile were added after one hour and the mixture was stirred for about another 40 hours at 70°C. The solvent was removed in vacuo and the residue obtained was mixed with ice water. The precipitate was suction filtered and dried. The aqueous phase was extracted with methylene chloride and evaporated. The combined precipitates were dissolved in ethyl acetate and stirred together with a little silica gel and 120 mg of charcoal for further purification. The suspension obtained was filtered and evaporated yielding a yellow resin. Yield: 518 mg (95 % of theory), Rf value: 0.40 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 394 [M+H]+ The following compounds were obtained analogously to Example IV: (1) 4-[(R)-(l-Phenyl-ethyl)amino]-7-[2-(4-methyl-perhydro- 1,4-diazepin-l-yl)-ethoxy]-6-nitro-quinazoline Rf value: 0.30 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 451 [M+H]+ (2) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-methyl-perhy- dro-1,4-diazepin-l-yl)-propyloxy]-6-nitro-quinazoline Rf value: 0.34 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 80:20:0.1) Mass spectrum (ESI + ) : m/z = 489, 491 [M+H]+ (3) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(azetidin-1-yl)- propyloxy]-6-nitro-quinazoline Rf value: 0.23 silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 432, 434 [M+H]+ Example V 4-[(R)-(1-Phenyl-ethyl)amino]-7-[2-(methanesulphonyloxy)- ethoxyl-6-nitro-quinazoline A solution of 1.79 ml methanesulphonic acid chloride in 10 ml of methylene chloride was added dropwise to a mixture of 8.08 g of 4-[{R)-(1-phenyl-ethyl)amino]-7-(2-hydroxy-ethoxy)-6- nitro-quinazoline and 4.53 ml of ethyl-diisopropylamine in 90 ml of methylene chloride while cooling with ice. The reaction mixture was stirred for about one hour at room temperature during which time a further 0.4 ml of methanesulphonic acid chloride and 0.5 ml of ethyl-diisopropylamine were added to complete the reaction. Subsequently the reaction mixture was mixed with ice water and stirred after the addition of saturated aqueous sodium carbonate solution. The organic phase was separated, washed with water, dried over magnesium sulphate and evaporated. The dark resinous residue obtained was crystallised by stirring with a little tert.butyl methylether, suction filtered and dried in a desiccator. Yield: 9.72 g (99 % of theory), Melting point: 128-134°C Mass spectrum (ESI): m/z = 431 [M-H]" The following compound was obtained analogously to Example V: (1) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(methanesulphonyl-oxy)-propyloxy]-6-nitro-quinazoline Rf value: 0.75 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI + ) : m/z = 471, 473 [M+H]+ Example VT 4-[(R)-(1-Phenyl-ethyl)amino]-7-(2-hydroxy-ethoxy)-6-nitro- quinazoline 2 ml of concentrated hydrochloric acid were added to 8.05 g of 4-[(R)-(l-phenyl-ethyl)amino]-7-[2-(tetrahydropyran-2-yloxy)- ethoxy]-6-nitro-quinazoline in 120 ml of methanol. After stirring for 1.5 hours at 50°C the reaction mixture was worked up by neutralising it with saturated sodium carbonate solution and evaporating it. The solid residue was dissolved in ethyl acetate and the solution obtained was washed with water, with saturated sodium chloride solution, dried over magnesium sulphate and evaporated. The yellow residue obtained was stirred with 20 ml of tert.butyl methylether, suction filtered and dried in a desiccator. Yield: 4.53 g (91 % of theory), Melting point: 192-194°C Mass spectrum (ESI"): m/z = 353 [M-H]" Example VII 4-[(3-chloro-4-fluorophenyl)amino]-7-(3-hydroxy-propyloxy)- 6-nitro-quinazoline Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-7-{3-[(tert.-butyl-dimethylsilyl)oxy]-propyloxy}-6-nitro-quinazoline by splitting off the protective silyl group with tetrabutyl ammonium fluoride in tetrahydrofuran. Yield: 94 % of theory, Rf value: 0.61 (silica gel, methylene chloride/methanol/concen- trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI"): m/z = 391, 393 [M-H] " Preparation of the end products: Example 1 4-[(3-Bromophenyl)amino]-7-[3-(1-methyl-piperidin-4-yl)propyl- oxyl -6- [(vinylcarbonyl) aminol -quinazoline To a solution of 300 mg of 6-amino-4-[(3-bromophenyl)amino]-7-[3-(1-methyl-piperidin-4-yl)propyloxy]-quinazoline in 7 ml of dichloromethane are added 0.28 ml of triethylamine. The reaction mixture is cooled to about -10°C in an ice/sodium chloride cooling bath. Then a solution of 59 μl of acrylic acid chloride in 1 ml of tetrahydrofuran is added dropwise within 10 minutes. The cooling bath is removed and the mixture is stirred for a further 15 minutes at ambient temperature. For working up, the reaction mixture is poured on to 2 0 ml of ice water and mixed with 2-3 ml of 2 N sodium hydroxide so¬lution, whereupon a light-coloured precipitate is formed. The precipitate is suction filtered, washed with cold water and dissolved in dichloromethane. The solution is dried over sodium sulphate and concentrated by evaporation. The resin¬like crude product is purified by chromatography over a silica gel column with methylene chloride/methanol/concentrated ammo¬nia solution (90:10:0.5). Yield: 118 mg (35 % of theory) Rf value: 0.35 (silica gel, methylene chloride/methanol/concentrated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 524, 526 [M+H]+ The following compounds are obtained analogously to Example 1: (1) 4-[(3-Bromophenyl)amino]-7-[2-(l-methyl-piperidin-4-yl)- ethoxy]-6- [(vinylcarbonyl)amino]-quinazoline Melting point: 129°C Mass spectrum (EST) : m/z = 510, 512 [M+H]+ (2) 4-[(3-Bromophenyl)amino]-7-[(l-methyl-piperidin-4-yl)meth- oxy]-6-[(vinylcarbonyl)amino]-quinazoline Melting point: 174°P Mass spectrum (EST) : m/z = 496, 498 [M+H]+ (3) 4-[(3-Bromophenyl)amino]-7-[(1-methyl-piperidin-4-yl)oxy]- 6-[(vinylcarbonyl)amino]-quinazoline Melting point: 166°C Mass spectrum (ESI+) : m/z = 482, 484 [M+H]+ (4) 4-[(3-Bromophenyl)amino]-7-[(l-methyl-piperidin-4-yl)oxy]- 6-[(l-oxo-2-buten-l-yl)amino]-quinazoline Rf value: 0.67 (silica gel, methylene chloride/methanol/concentrated aqueous ammonia solution = 40:10:0.5) Mass spectrum (ESI+) : m/z = 496, 498 [M+H] + (5) 4-[(3-Bromophenyl)amino]-7-[(1-methyl-piperidin-4-yl)meth- oxy]-6-[(l-oxo-2-buten-l-yl)amino]-quinazoline Rf value: 0.45 (aluminium oxide, activity III; ethyl acetate/methanol = 4:1) Mass spectrum (EI): m/z = 509, 511 [M]+ (6) 4-[(3-Bromophenyl)amino]-7-[3-(l-methyl-piperidin-4-yl)- propyloxy]-6-[(3-ethoxycarbonyl-l-oxo-2-propen-l-yl)amino]- quinazoline Rf value: 0.28 (silica gel, methylene chloride/methanol/concen trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI + ) : m/z = 596, 598 [M+H]+ I (7) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(1-methyl-piperi- din-4-yl)propyloxy]-6-[(vinylcarbonyl)amino]-quinazoline Rf value: 0.33 (silica gel, methylene chloride/methanol/concen trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI + ) : m/z = 498, 500 [M+H]+ (8) 4-[(R)-(1-Phenyl-ethyl)amino]-7-[2-(azetidin-1-yl)- ethoxy]-6-[(vinylcarbonyl)amino]-quinazoline Rf value: 0.60 (silica gel, methylene chloride/methanol/concen- trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI"): m/z = 416 [M-H]" (9) 4-[(R)-(1-Phenyl-ethyl)amino]-7-[2-(4-methyl-perhydro- 1,4-diazepin-l-yl)-ethoxy]-6-[(vinylcarbonyl)amino]- quinazoline Rf value: 0.37 (silica gel, methylene chloride/methanol/concen- trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI"): m/z = 473 [M-H]" (10) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-methyl- perhydro-1,4-diazepin-l-yl)-propyloxy]-6-[(vinylcarbonyl)- amino]-quinazoline Rf value: 0.29 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI+) : m/z = 513, 515 [M+H]+ (11) 4- [ (3-chloro-4-fluorophenyl)amino]-7-[3-(azetidin-1-yl)- propyloxy]-6-[(vinylcarbonyl)amino]-quinazoline Rf value: 0.39 (silica gel, methylene chloride/methanol/concen-trated aqueous ammonia solution = 90:10:0.1) Mass spectrum (ESI"): m/z = 454, 456 [M-H]" Example 2 4-[(3-Bromophenyl)amino]-7-[3-(1-methyl-piperidin-4-yl)propyl¬ oxy! -6- r M -oxo-2 , 4-hexadi p.n-1 -yl ) amino! -quinazonline To 31 mg of sorbic acid in 1 ml of tetrahydrofuran are added 40 μl of isobutyl chloroformate followed by 45 μl of N-methyl-morpholine whilst cooling with an ice bath. The white suspen¬sion is stirred for one minute, then a solution of 100 mg of 6-amino-4-[(3-bromophenyl)amino]-7-[3-(1-methyl-piperidin-4-yl)propyloxy]-quinazoline in 1.5 ml of pyridine is added. The ice bath is removed and the reaction mixture is stirred overnight. For working up, it is poured onto 20 ml of ice water, stirred for 30 minutes and adjusted to pH 9-10 with a few drops of 2 N sodium hydroxide solution. The aqueous phase is extracted with methylene chloride, the combined organic phases are dried over sodium sulphate and concentrated by eva¬poration. The resin-like crude product is purified by chroma¬tography over an aluminium oxide column (activity III) with methylene chloride/methanol (99.5.-0.5). Yield: 62 mg (52 % of theory), Rt value: 0.29 (aluminium oxide, activity III; methylene chloride/methanol = 98:2) Mass spectrum (EI): m/z = 563, 565 [M]+ The following compounds are obtained analogously to Example 2: (1) 4-[(3-Bromophenyl)amino]-7-[3-(l-methyl-piperidin-4-yl)- propyloxy]-6-[(l-oxo-2-buten-l-yl)amino]-quinazoline Rt value: 0.26 (aluminium oxide, activity III; methylene chloride/methanol = 98:2) Mass spectrum (ESI+) : m/z = 538, 540 [M+H]+ (2) 4-[(3-Bromophenyl)amino]-7-[3-(l-methyl-piperidin-4-yl)- propyloxy]-6-[(3-phenyl-l-oxo-2-propen-l-yl)amino]-quinazoline R£ value: 0.26 (aluminium oxide, activity III; methylene chloride/methanol = 98:2) Mass spectrum (EI): m/z = 599, 601 [M]* (3) 4-[(3-Bromophenyl)amino]-7-[3-(l-methyl-piperidin-4-yl)- propyloxy]-6-[(l-oxo-2-butyn-l-yl)amino]-quinazoline Rt value: 0.4 0 (aluminium oxide, activity III; methylene chloride/methanol = 98:2) Mass spectrum (ESI + ) : m/z = 536, 538 [M+H] + Example 3 4- [ (3-chloro-4-fluorophenyl)amino]-6-{ [4-(N,N-diethylamino)-1-oxo-2-buten-l-yllamino}-7-cyclopropylmethoxy-qui naznli ne To a solution of 640 mg of 4-bromo-2-butenoic acid in 10 ml of methylene chloride are added, at ambient temperature, 0.67 ml of oxalyl chloride and one drop of dimethylformamide. The reaction mixture is stirred for about another half hour at am¬bient temperature, until the development of gas has ceased. The acid chloride formed is substantially freed from solvent in vacuo using a rotary evaporator. Then the crude product is dissolved in 10 ml of methylene chloride and added dropwise, whilst cooling with an ice bath, to a mixture of 1.00 g of 6-amino-4-[(3-chloro-4-fluorophenyl)amino]-7-cyclopropylmeth-oxy-quinazoline and 1.60 ml of Hiinig base in 50 ml of tetra-hydrofuran. The reaction mixture is stirred for 1.5 hours in an ice bath and for a further 2 hours at ambient temperature. Then 2.90 ml of diethylamine are added and the mixture is stirred for 2.5 days at ambient temperature. To work it up, the reaction mixture is filtered and the filtrate is concen¬trated by evaporation. The filter residue is purified by chro¬matography over a silica gel column with ethyl acetate/metha-nol (19:1). Yield: 550 mg (40 % of theory), Melting point: 114 °C Mass spectrum (ESI + ) : m/z = 498, 500 [M+H]+ The following compounds are obtained analogously to Example 3: (1) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(morpholin-4-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline Rt value: 0.53 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI"): m/z = 510, 512 [M-H] (2) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-ethyl-pipera- zin-l-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-qui- nazoline Rt value: 0.44 (silica gel, ethyl acetate/methanol/concentrated aqueous ammonia solution = 9:1:0.1) Mass spectrum (EI): m/z = 538, 540 [M]+ (3) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2,6-dimethyl- morpholin-4-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmeth- oxy-quinazoline Melting point: 160°C Mass spectrum (ESI + ) : m/z = 540, 542 [M+H]+ (4) 4-[(3-chloro-4-fluorophenyl)amino]-6- {[4-(dimethylamino)- l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline Melting point: 137°C Mass spectrum (EST) : m/z = 470, 472 [M+H] + (5) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(1-oxido-thiomor- pholin-4-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy- quinazoline Melting point: 239°C Mass spectrum (ESI+) : m/z = 544, 546 [M+H]+ (6) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(morpholin-4-yl)- l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline Rt value: 0.45 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (EST) : m/z = 512, 514 [M+H]+ (7) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(morpholin-4-yl)- l-oxo-2-buten-l-yl]amino}-7-cyclopentyloxy-quinazoline Melting point: 143°C Rt value: 0.45 (silica gel, ethyl acetate/methanol = 9:1) (8) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(diethylamino)- l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline Melting point: 111°C Rf value: 0.21 (silica gel, ethyl acetate/methanol = 9:1) (9) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(diethylamino)- l-oxo-2-buten-l-yl]amino}-7-cyclopentyloxy-quinazoline Melting point: 105°C Rt value: 0.23 (silica gel, ethyl acetate/methanol = 9:1) (10) 4-[(R)-(1-Phenyl-ethyl)amino]-6-{[4-(morpholin-4-yl)- l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline Rt value: 0.33 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI+) : m/z = 488 [M+H]+ (11) 4-[(R)-(1-Phenyl-ethyl)amino]-6-{[4-(morpholin-4-yl)- l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline Rf value: 0.37 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI+) : m/z = 488 [M+H]+ (12) 4-[(R)-(1-Phenyl-ethyl)amino]-6-{[4-(morpholin-4-yl)- l-oxo-2-buten-l-yl]amino}-7-cyclopentyloxy-quinazoline Rf value: 0.35 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI+) : m/z = 502 [M+H]+ (13) 4- [ (R)-(1-Phenyl-ethyl)amino]-6-{[4-(diethylamino)-1-oxo- 2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline Rt value: 0.26 (silica gel, ethyl acetate/methanol = 4:1) Mass spectrum (ESI+) : m/z = 474 [M+H]+ (14) 4- [ (i?) - (1-Phenyl-ethyl) amino] -6- { [4- (diethylamino) -l-oxo- 2-buten-l-yl]amino}-7-cyclopentyloxy-quinazoline Rt value: 0.31 (silica gel, ethyl acetate/methanol = 4:1) Mass spectrum (ESI+) : m/z = 488 [M+H]+ (15) 4-[(R)-(1-Phenyl-ethyl)amino]-6-{[4-(diethylamino)-1-oxo- 2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline Rt value: 0.15 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI + ) : m/z = 474 [M+H]+ (16) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(l-methyl-piperidin-4-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmethoxy-quinazoline Rt value: 0.28 (silica gel, ethyl acetate/methanol/concen- trated aqueous ammonia solution = 80:20:2) Mass spectrum (ESI+) : m/z = 553, 555 [M+H]+ (17) 4- [ (3-chloro-4,-f luorophenyl) amino] -6- ({4- [ (R) -2-methoxy- methyl-pyrrolidin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclo¬propylmethoxy- quinazoline Rt value: 0.33 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI+) : m/z = 540, 542 [M+H]+ (18) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(S)-2-methoxy- methyl-pyrrolidin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclopro- pylmethoxy-quinazoline Melting point: 120°C Mass spectrum (ESI+) : m/z = 540, 542 [M+H]+ (19) 4- [ (3-chloro-4-fluorophenyl)amino]-6-({4-[bis-(2-methoxy- ethyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmethoxy- quinazoline Rt value: 0.51 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI+) : m/z = 558, 560 [M+H]+ (20) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-ethyl- N-(2-methoxyethyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclo- propylmethoxy-quinazoline Rf value: 0.33 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI + ) : m/z = 528, 530 [M+H]+ (21) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(piperidin- 1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quina- zoline Rt value: 0.22 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI + ) : m/z = 510, 512 [M+H]+ (22) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2-methyl-pipe- ridin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy- quinazoline Rf value: 0.21 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI + ) : m/z = 524, 526 [M+H] + (23) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(pyrrolidin- 1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quina- zoline Rf value: 0.10 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (EST) : m/z = 496, 498 [M+H]+ (24) 4-[(3-chloro-4-fluorophenyl)amino] -6-{ [4-(4-cyclopropyl- methyl-piperazin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopro- pylmethoxy-quinazoline Melting point: 117°C Mass spectrum (EST) : m/z = 565, 567 [M+H]+ (25) 4- [ (3-chloro-4-fluorophenyl)amino]-6-{[4-(2-methyl-pyrro- lidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy- quinazoline Melting point: 108-110°C Rf value: 0.27 (silica gel, ethyl acetate/methanol = 9:1) (26) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(te- trahydropyran-4-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclo- propylmethoxy-quinazoline R£ value: 0.29 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI"): m/z = 538, 540 [M-H]" (27) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(cis-2,6-di¬ methyl -piperidin-1-yl) -l-oxo-2-buten-l-yl]amino}-7-cyclo- propylmethoxy-quinazoline Rf value: 0.27 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI"): m/z = 536, 538 [M-H]" (28) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2,5-dimethyl- pyrrolidin-1-yl)-1-oxo-2-buten-1-yl]amino}-7-cyclopropyl- methoxy-quinazoline Rf value: 0.36 (silica gel, ethyl acetate/methanol =9:1) Mass spectrum (ESI"): m/z = 522, 524 [M-H]" (29) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(diethylamino)- l-oxo-2-buten-l-yl]amino}-7-[(tetrahydrofuran-2-yl)methoxy]- quinazoline Rf value: 0.35 (silica gel, ethyl acetate/methanol/concen- trated aqueous ammonia solution = 9:1:0.1) Mass spectrum (ESI"): m/z = 526, 528 [M-H] " (30) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(diethylamino)- l-oxo-2-buten-l-yl]amino}-7-[(S)-(tetrahydrofuran-3-yl)oxy]- quinazoline Melting point: 119°C Mass spectrum (ESI"): m/z = 512, 514 [M-H]" (31) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-diethylamino- methyl-piperidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclo- propylmethoxy-quinazoline Rf value: 0.20 (silica gel, methylene chloride/methanol = 9:1) Mass spectrum (ESI"): m/z = 593, 595 [M-H]" (32) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N-methyl- N-cyclopropylmethyl-amino)-i-oxo-2-buten-l-yl]amino}- 7-cyclopropylmethoxy-quinazoline Rf value: 0.73 (silica gel, methylene chloride/methanol = 9:1) Mass spectrum (ESI+) : m/z = 510, 512 [M+H]+ (33) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(2-methoxypropyl)-amino]-l-oxo-2-buten-l-yl}amino)- 7-cyclopropylmethoxy-quinazoline (The N-methyl- N-(2-methoxypropyl)-amine used was prepared by reacting 2-methoxypropionic acid chloride with methylamine and subsequently reducing with lithium aluminium hydride) Melting point: 123-125°C Rf value: 0.66 (silica gel, methylene chloride/methanol = 9:1) (34) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(3-methoxypropyl)-amino]-l-oxo-2-buten-l-yl}amino)- 7-cyclopropylmethoxy-quinazoline Rf value: 0.66 (silica gel, methylene chloride/methanol = 9:1) Mass spectrum (EST) : m/z = 528, 530 [M+H]+ (35) 4-[(3-chloro-4-fluorophenyl)amino] -6-{[4-(4-methoxy- piperidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropyl- methoxy-quinazoline Melting point: 129-130°C Rf value: 0.20 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI'): m/z = 538, 540 [M-H]" (36) 4-[(3-chloro-4-fluorophenyl)amino] -6-{[4-(4-hydroxy- piperidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropyl- methoxy-quinazoline Rf value: 0.3 0 (silica gel, methylene chloride/methanol/concen- trated aqueous ammonia solution = 9:1:0.1) Mass spectrum (ESI"): m/z = 524, 526 [M-H]" (37) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(diethylamino) - l-oxo-2-buten-l-yl]amino}-7-[(tetrahydropyran-4-yl)oxy]- quinazoline Rf value: 0.47 (silica gel, methylene chloride/methanol = 9:1) Mass spectrum (ESI): m/z = 528, 530 [M-H]" (38) 4-[(3-chloro-4-fluorophenyl)amino] -6-({4-[N-methyl-N- (tetrahydrofuran-2-yl-methyl)-amino]-l-oxo-2-buten-l- yl}amino)- 7-cyclopropylmethoxy-quinazoline Melting point: from 145°C (decomposition) Rf value: 0.23 (silica gel, methylene chloride/methanol = 15:1) Mass spectrum (ESI+) : m/z = 540, 542 [M+H]+ (39) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N- (tetrahydrofuran-3-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7- cyclopropylmethoxy-quinazoline (The starting N-methyl-N-(3-tetrahydrofuranyl)-amine was pre¬pared by reaction of tetrahydrofuran-3-carboxylic acid with diphenyl phosphonate azide in benzyl alcohol and subsequent reduction of the 3-(benzyloxycarbonylamino)-tetrahydrofuran obtained with lithium aluminium hydride) Melting point: 157-;L590C Rf value: 0.23 (silica gel, methylene chloride/methanol = 15:1) Mass spectrum (ESI + ) : m/z = 526, 528 [M+H]+ (40) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(1-methoxy-2-propyl)-amino]-l-oxo-2-buten-l-yl}amino)- 7-cyclopropylmethoxy-quinazoline (The starting N-methyl-N-(l-methoxy-2-propyl)-amine was prepared by reductive amination of methoxyacetone with methylamine hydrochloride and sodium triacetoxyborohydride in the presence of sodium acetate. The reaction was carried out in tetrahydrofuran) Rf value: 0.38 (silica gel, ethyl acetate/methanol = 9:1) Mass spectrum (ESI+) : m/z = 528, 530 [M+H]+ The following compounds may also be obtained analogously to the above Examples and other methods known from the litera¬ture : (1) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quina-zoline (2) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dibutyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quina-zoline (3) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(piperidin-1-yl)- l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline (4) 4-[(3-chloro-4-fluorophenyl)amino] -6-{ [4-(2, 6-dimethyl-morpholin-4-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmeth-oxy-quinazoline (5) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-methyl-pipera-zin-l-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-qui-nazoline (6) 4- [ (3-chloro-4-fluorophenyl)amino]-6-{[4-(4-cyclopropylme-thyl-piperazin-1-yl)-l-oxo-2-buten-l-yl] amino}-7-cyclopropyl-methoxy-quinazoline (7) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-cyclopropyl-piperazin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmeth-oxy-quinazoline (8) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-methylsulpho-nyl-piperazin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropyl-methoxy-quinazoline (9) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-acetyl-pipera-zin-l-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-qui-nazoline (10) 4-[(3-chloro-4-fluorophenyl)amino]-6-[(4-{4-[(N,N-di-methylamino)carbonyl]-piperazin-1-yl}-l-oxo-2-buten-l-yl)-amino]-7-cyclopropylmethoxy-quinazoline (11) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(pyrrolidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quina-zoline (12) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N-cyclopropyl- N-methylamino)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy- quinazoline (13) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N-cyclopropyl- methyl-N-methylamino)-l-oxo-2-buten-l-yl]amino}-7-cyclopropyl- methoxy-quinazoline (14) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethyl- amino)-l-oxo-2-butyn-l-yl]amino}-7-cyclopropylmethoxy-quina- zoline (15) 4-[(3-chloro-4-fluorophenyl)amino]-6- {[4-(N,N-diethyl- amino)-l-oxo-2-butyn-l-yl]amino}-7-cyclopropylmethoxy-quina- zoline (16) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(piperidin-1-yl)-l-oxo-2-butyn-l-yl]amino}-7-cyclopropylmethoxy-quinazoline (17) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(morpholin-4-yl)-l-oxo-2-butyn-l-yl]amino}-7-cyclopropylmethoxy-quinazoline (18) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-methyl-pipera-zin-l-yl)-l-oxo-2-butyn-l-yl]amino}-7-cyclopropylmethoxy-qui-nazoline (19) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-methylsulpho-nyl-piperazin-1-yl)-l-oxo-2-butyn-l-yl]amino}-7-cyclopropyl-methoxy-quinazoline (20) 4-[(3-chloro-4-fluorophenyl)amino] -6-{[4-(morpholin-4-yl)-1,4-dioxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline (21) 4-[(3-chloro-4-fluorophenyl)amino] -6-({4-[(3-N,N-dimethyl-amino-propan-1-yl)amino]-1,4-dioxo-2-buten-l-yl}amino]-7-cyclopropylmethoxy-quinazoline (22) 4-t(3-chloro-4-fluorophenyl)amino]-6-({2-[(N,N-diethyl-amino)methyl]-1-oxo-2-propen-1-yl}amino]-7-cyclopropylmethoxy-quinazoline (23) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2-methoxymethyl-pyrrolidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmeth-oxy-quinazoline (24) 4- [ (3-chloro-4-fluorophenyl)amino]-6-({4-[N,N-bis(2-meth-oxyethyl)amino]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmeth-oxy-quinazoline (25) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-(2-methoxy-ethyl)-N-methylamino]-l-oxo-2-buten-l-yl}amino)-7-cyclopro-pylmethoxy-quinazoline (26) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclobutylmethoxy-quina-zoline (27) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclopentylmethoxy-quina-zoline (28) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclohexylmethoxy-quina-zoline (29) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethyl- amino)-l-oxo-2-buten-l-yl]amino}-7-(2-cyclopropyl-ethoxy)- quinazoline (30) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethyl-amino)-l-oxo-2-buten-l-yl]amino}-7-(3-cyclopropyl-propyloxy)-quinazoline (31) 4- [ (3-chloro-4-fluorophenyl)amino]-6-({4-[4-(tetrahydro-furan-3-yl)-piperidin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclo-propylmethoxy-quinazoline (32) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[4-(morpholin-4-yl)-piperidin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclo-propylmethoxy-quinazoline (33) 4-[(3-chloro-4-fluorophenyl)amino] -6-({4-[4-(tetrahydrofu-ran-3-yl)-piperazin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclo-propylmethoxy-quinazoline (34) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[4-(tetrahydrofu-ran-2-yl-methyl)-piperazin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmethoxy-quinazoline (35) 4-[(3-chloro-4-fluorophenyl)amino]-6-[(4-(N-methyl-N-[1-(tetrahydrofuran-3-yl)-piperidin-4-yl]-amino}-1-oxo-2-buten-l-yl)amino]-7-cyclopropylmethoxy-quinazoline (36) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(S)-2-methoxyme- thyl-pyrrolidin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclobutyl-oxy-quinazoline (37) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(R)-2-methoxyme- thyl-pyrrolidin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclobutyl-oxy-quinazoline (38) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[bis-(2-methoxy-ethyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclobutyloxy-quina-zoline (39) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(2-methoxyethyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclo-butyloxy-quinazoline (4 0) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(S)-N-methyl- N-(1-methoxy-2-propyl)-amino]-l-oxo-2-buten-l-ylJamino)-7-cyclobutyloxy-quinazoline (41) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(R)-N-methyl- N-(1-methoxy-2-propyl)-amino]-l-oxo~2-buten-l-yl}amino)-7-cyclobutyloxy-quinazoline (42) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(1-methoxy-2-propyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmethoxy-quinazoline (43) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(2-methoxypropyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmethoxy-quinazoline (44) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(3-methoxypropyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmethoxy-quinazoline (45) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(te-trahydrofuran-3-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclo-propylmethoxy-quinazoline (46) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(S)-N-methyl- N-(tetrahydrofuran-3-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclobutyloxy-quinazoline (47) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[{R)-N-methyl- N-(tetrahydrofuran-3-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclobutyloxy-quinazoline (48) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(te- trahydropyran-4-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclo- propylmethoxy-quinazoline (49) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(te- trahydropyran-4-yl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclo¬ butyloxy-quinazoline (50) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(4-cyclopropyl-piperazin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline (51) 4- [ (3-chloro-4-fluorophenyl)amino]-6-{ [4-(4-cyclopropylme-thyl-piperazin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyl-oxy-quinazoline (52) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N-cyclopropyl-N-methyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline (53) 4- [ (3-chloro-4-fluorophenyl)amino]-6-{[4-(N-cyclopropylme-thyl-N-methyl-amino)-1 -oxo-2-buten-1-yl]amino}-7-cyclobutyl-oxy-quinazoline (54) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl-N-(te-trahydrofuran-2-ylmethyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-cyclopropylmethoxy-quinazoline (55) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(R)-N-methyl- N-(tetrahydrofuran-2-ylmethyl)-amino]-l-oxo-2-buten-l-yl}-amino)-7-cyclobutyloxy-quinazoline (56) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[(S)-N-methyl- N-(tetrahydrofuran-2-ylmethyl)-amino]-l-oxo-2-buten-l-yl}-amino)-7-cyclobutyloxy-quinazoline (57) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(pyrrolidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline (58) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2-methyl-pyrro-lidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quina¬zoline - (59) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2,5-dimethyl- pyrrolidin-1-yl)-l-oxo-2-buten-l-yl] amino}-7-cyclobutyloxy- quinazoline (60) 4-[(3-chloro~4-fluorophenyl)amino]-6-{[4-(piperidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline (61) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2-methyl-piperi-din-l-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazo¬line (62) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(2,6-dimethyl-piperidin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline (63) 4- [ (3-chloro-4-fluorophenyl)amino]-6-{ [4-(4-hydroxy-pipe-ridin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazo¬line (64) 4- [ (3-chloro-4-fluorophenyl)amino]-6-{[4-(4-methoxy-pipe-ridin-1-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazo¬line (65) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[4-(2-methoxy-ethyl)-piperazin-1-yl]-l-oxo-2-buten-l-yl}amino)-7-cyclobu¬tyloxy-quinazoline (66) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(3-methyl-morpho-lin-4-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazo¬line (67) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(3,5-dimethyl-morpholin-4-yl)-l-oxo-2-buten-l-yl]amino}-7-cyclobutyloxy-quinazoline (68) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(2-methoxyethyl)-amino]-l-oxo-2~buten-l-yl}amino)-7-(tetra-hydrofuran-3-yl-oxy)-quinazoline (69) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(2-methoxyethyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-(tetra-hydropyran-4-yl-oxy)-quinazoline (70) 4-[(3-chloro-4-fluorophenyl)amino]-6-({4-[N-methyl- N-(2-methoxyethyl)-amino]-l-oxo-2-buten-l-yl}amino)-7-(tetra-hydrofuran-2-yl-methoxy)-quinazoline (71) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(azetidin-1-yl)-propyloxy]-6-[(vinylcarbonyl)amino]-quinazoline (72) 4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-methyl-homopi-perazin-1-yl)propyloxy]-6-[(vinylcarbonyl)amino]-quinazoline Example 4 floated tablets containing 75 mg of active substance 1 tablet core contains: active substance 75.0 mg calcium phosphate 93.0 mg corn starch 3 5.5 mg polyvinylpyrrolidone 10.0 mg hydroxypropylmethylcellulose 15.0 mg magnesium stearate l.5 mg 23 0.0 mg Preparation: The active substance is mixed with calcium phosphate, corn starch, polyvinylpyrrolidone, hydroxypropylmethylcellulose and half the specified amount of magnesium stearate. Blanks 13 mm in diameter are produced in a tablet-making machine and these are then rubbed through a screen with a mesh size of 1.5 mm using a suitable machine and mixed with the rest of the magne¬sium stearate. This granulate is compressed in a tablet-making machine to form tablets of the desired shape. Weight of core: 23 0 mg die: 9 mm, convex The tablet cores thus produced are coated with a film consis¬ting essentially of hydroxypropylmethylcellulose. The finished film-coated tablets are polished with beeswax. Weight of coated tablet: 245 mg. Example 5 Tablets containing 100 mg of active substance Composition: 1 tablet contains: active substance 100.0 mg lactose 80.0 mg corn starch 34.0 mg polyvinylpyrrolidone 4.0 mg magnesium stearate 2.0 mg 22 0.0 mg Method nf Preparation: The active substance, lactose and starch are mixed together and uniformly moistened with an aqueous solution of the polyvinyl¬pyrrolidone. After the moist composition has been screened (2.0 mm mesh size) and dried in a rack-type drier at 50°C it is screened again (1.5 mm mesh size) and the lubricant is added. The finished mixture is compressed to form tablets. Weight of tablet: 220 mg Diameter: 10 mm, biplanar, facetted on both sides and notched on one side. Example 6 Tablets containing 150 tng of activ. substance Composition: 1 tablet contains: active substance powdered lactose corn starch colloidal silica polyvinylpyrrolidone magnesium stearate 50.0 mg 89.0 mg 4 0.0 mg 10.0 mg 10.0 mg 1.0 mg 3 00.0 mg Preparation: The active substance mixed with lactose, corn starch and silica is moistened with a 20% aqueous polyvinylpyrrolidone solution and passed through a screen with a mesh size of 1.5 mm. The granules, dried at 45°C, are passed through the same screen again and mixed with the specified amount of magnesium stea¬rate. Tablets are pressed from the mixture. Weight of tablet: 300 mg die: 10 mm, flat Example 7 Hard gelatine capsules containing 150 mg of active substance 1 capsule contains: active substance corn starch (dried) lactose (powdered) magnesium stearate approx. approx. approx. 50.0 mg 80.0 mg 87.0 mg 3.0 mg 42 0.0 mg Preparation; The active substance is mixed with the excipients, passed through a screen with a mesh size of 0.75 mm and homogeneously mixed using a suitable apparatus. The finished mixture is packed into size 1 hard gelatine capsules. Capsule filling: approx. 320 mg Capsule shell: size 1 hard gelatine capsule. Example 8 Suppositories containing 1 BO mg of active substance 1 suppository contains: active substance 150.0 mg polyethyleneglycol 1500 550.0 mg polyethyleneglycol 6000 460.0 mg polyoxyethylene sorbitan monostearate 840.0 mg 2,000.0 mg Preparation: After the suppository mass has been melted the active substance is homogeneously distributed therein and the melt is poured into chilled moulds. Example 9 Suspension containing 50 mg of active substance 1.00 g 0.10 g 0.05 g 0.01 g 10.00 g 5.00 g 20.00 g 0.30 g 100 ml of suspension contain: active substance carboxymethylcellulose-Na-salt methyl p-hydroxybenzoate propyl p-hydroxybenzoate glucose glycerol 70% sorbitol solution flavouring dist. water ad 100 ml Preparation : The distilled water is heated to 70°C. The methyl and propyl p-hydroxybenzoates together with the glycerol and sodium salt of carboxymethylcellulose are dissolved therein with stirring. The solution is cooled to ambient temperature and the active substance is added and homogeneously dispersed therein with stirring. After the sugar, the sorbitol solution and the fla¬vouring have been added and dissolved, the suspension is eva¬cuated with stirring to eliminate air. 5 ml of suspension contain 50 mg of active substance. Example 10 10.0 mg ad 2.0 ml Ampoules containing 10 mg active substance Composition: active substance 0.01 N hydrochloric acid q.s double-distilled water Preparation: The active substance is dissolved in the necessary amount of 0.01 N HC1, made isotonic with common salt, filtered sterile and transferred into 2 ml ampoules. Example. 11 Ampoules containing 50 mg of active substance 50.0 mg 10.0 ml Composition: active substance 0.01 N hydrochloric acid q.s. double-distilled water ad Preparation: The active substance is dissolved in the necessary amount of 0.01 N HCl, made isotonic with common salt, filtered sterile and transferred into 10 ml ampoules. Example 12 Capsules for powder inhalation containing 5 mg of active substance 1 capsule contains: active substance 5.0 mg lactose for inhalation 15.o mg 20.0 mg Preparation: The active substance is mixed with lactose for inhalation. The mixture is packed into capsules in a capsule-making machine (weight of the empty capsule approx. 50 mg). weight of capsule: 70.0 mg size of capsule = 3 Example 13 Solution for inhalation for hand-held nebulisers containing 2.5 mg active substance 1 spray contains: active substance 2.500 mg benzalkonium chloride 0.001 mg IN hydrochloric acid q.s. ethanol/water (50/50) ad 15.000 mg Preparation: The active substance and benzalkonium chloride are dissolved in ethanol/water (50/50). The pH of the solution is adjusted with IN hydrochloric acid. The resulting solution is filtered and transferred into suitable containers for use in hand-held nebulisers (cartridges). Contents of the container: 4.5 g WE CLAIM: 1. Bicyclic heterocycles of general formula wherein Ra denotes a hydrogen atom, Ra denotes a phenyl, benzyl or 1-phenylethyl group, whilst the phenyl nucleus is substituted in each case by the radicals R1 and R2, whilst R1 and R2, which may be identical or different, each denotes a hydrogen, fluorine, chlorine or bromine atom, X denotes a nitrogen atom, A denotes an imino group, B denotes a carbonyl group, C denotes a 1, 2-vinylene, ethynylene or 1, 3-butadien-l, 4-ylene group, D denotes an C1-3 -alkylene group, E denotes a Di-(C1-4-alkyl)-arnino group, wherein the alkyl moieties may be identical or different, a methylamino or ethylamino group each substituted at the nitrogen atom by a 2-methoxy-ethyl, l-methoxy-2-propyl, 2-methoxy-propyl, 3-methoxy-propyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl, tetrahydrofuran-2-ylmethyl, 1 -methyl-piperidin-4-yl, 1 -ethyl-piperidin-4-yl, 1 -(tetrahydrofuran-3-yl)-piperidin-4-yl,cyclopropyl or cyclopropylmethyl group, a bis- (2-methoxyethyl) -amino group, a pyrrolidine, piperidino or morpholino group each optionally substituted by one or two methyl groups. a piperazino group substituted in 4-position by a methyl, ethyl, cyclopropyl, cyclopropylmethyl, 2-methoxy-ethyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl or Letrahydrofuran-2-ylmethyl group, a thiomorpholino, S-oxido-thiomorpholino or S, S-dioxidothiomorpholino group, a 2-(methoxymethyl)-pyrrolidino, 2-(ethoxymethyl)-pyrrolidino, 4-hydroxy-piperidino, 4-methoxy-piperidino, 4-ethoxy-piperidino, 4- (tetrahydrofuran-3-yl) -piperidino or 4-morpholino-piperidino group, and Rc denotes a cyclopropylmethoxy, cyclobutylmethoxy, cyclopentyloxy or cyclohexylmethoxy group, a cyclobutyloxy, cyclopentyloxy or cyclohexyloxy group, a tetrahydrofuran-3-yloxy, tetrahydropyran-4-yloxy or tetrarnydrofuran-2-ylmethoxy group, the tautomers, stereoisomers and salts thereof. 2. Bicyclic heterocycles of general formula I as claimed in claim 1, wherein Ra denotes a hydrogen atom, Rb denotes a 1-phenylethyl group or a phenyl group wherein the phenyl nucleus is substituted by the radicals R1 and R, whilst R1 and R2, which may be identical or different, each denote a hydrogen, fluorine, chlorine or bromine atom, X denotes a nitrogen atom, A denotes an imino group, B denotes a carbonyl group, C denotes a 1, 2-vinylene, ethynylene or 1, 3-butadien-l, 4-ylene group, D denotes a methylene group, E denotes a dimethylamino, diethylamino, bis-(2-methoxy-ethyl)-amino, N-methyl-N-(2-methoxy-ethyl)-arnino, N-ethyl-N-(2-methoxy-ethyl) -amino, N-methyl-N-cyclopropyl-amino, N-methyl-N-cyclopropylmethyl-amino, N- methyl-N-(l-methoxy-2-propyl)-amino, N-methyl-N-(2-methoxy-propyl)- amino, N-methyl-N-(3-methoxy-propyl) -amino-, N-methyl-N-(tetra- hydrofuran-3-yl)-amino, N-methyl-N- tetrahydropyran-4-yl) -amino, N- methyl-N-(tetrahydrofuran-2-ylmethyl) -amino or N-methyl-N- (1-methyl- piperidin-4-yl)-amino group, a pyrrolidino, piperidino or morpholino group each optionally substituted by one or two methyl groups, a piperazino group substituted in the 4-position by a methyl, ethyl, cyclopropylmethyl or 2-methoxy-ethyl group, an S-oxido-thiomorpholino group, a 2- (methoxy-methyl) -pyrrolidino, 4-hydroxy-piperidino or 4-methoxy- piperidino group, and Rc denotes a cyclopropylmethoxy, cyclobutyloxy or cyclopentyloxy group, a tetrahydrofuran-3-yloxy, tetrahydropyran-4-yloxy or tetra-hydrofuran-2- ylmethoxy group, the tautomers, stereoisomers and salts thereof. 3. The following compounds of general formula I as claimed in claim 1: (a) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-diethyl-amino)-l-oxo-2-buten-l-yl]amino}-7-cyclopropylmethoxy-quinazoline and (b) 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(morpholin-4-yl)-l-oxo-2-buten-1-yl] amino}-7-cyclopropylmethoxy-quinazoline as well as the salts thereof. 4. Physiologically acceptable salts of the compounds as claimed in' with inorganic or organic acids or bases. 5. Process for preparing the compounds of general formula I as claimed in claims 1 to 4, wherein a compound of general formula , (ID wherein Ra to Rc, A and X are defined as in claims 1 to 3, is reacted with a compound of general formula Z1 — B — C — D — E , (III) wherein B to E are defined as in claims 1 to 3 and Z1 denotes a leaving group such as a halogen atom, e.g. a chlorine or bromine atom, or a hydroxy group, while the reaction is optionally carried out in a solvent or mixture of solvents such as methylene chloride, dimethylform-amide, benzene, toluene, chlorobenzene, tetrahydrofuran, benzene/tetrahydrofuran or dioxane optionally in the presence of an organic base, e.g. a tertiary organic base such as triethylamine, pyridine, 2-dimethylaminopyridine or N-ethyl— diisopropylamine (Hunig base) , whilst these organic bases may simultaneously also act as solvent, or in the presence of an inorganic base such as sodium carbonate, potassium carbonate or sodium hydroxide solution and optionally in the presence of a dehydrating agent, e.g. in the presence of isobutyl chloroformate, thionyl chloride, trimethyl chlorosilane, phosphorus trichloride, phosphorus pentoxide, hexamethyl-disilazane, N,N' -dicyclohexylcarbodiimide, N, N'-dicyclohexylcarbodiimide/N- hydroxysuccinimide or 1-hydroxy-benzotriazole and optionally also in the presence of 4-dimethylamino-pyridine, N, N'-carbonyldiimidazole or triphenylphosphine/carbon tetrachloride, at temperatures between -50 and 150°C, preferably at temperatures between -20 and 80°C, whereas, if Z1 denotes a hydroxy group, the reaction is preferably carried out in the presence of a dehydrating agent as mentioned above, in a solvent such as methylene chloride, tetrahydrofuran, dioxane, toluene, chlorobenzene, dimethylsulphoxide, ethylene glycol monomethylether, ethyleneglycol, diethylether or sulpholane and optionally in the presence of a reaction accelerator such as 4-dimethylaminopyridine at temperatures between -50 and 150°C, but preferably at temperatures between -20 and 80°C, and if desired a compound of general formula I thus obtained which contains an amino, alkylammo or imino group is converted by acylation or sulphonylation into a corresponding acyl or sulphonyl compound of general formula I and/or a compound of general formula I thus obtained which contains an amino, alkylamino or imino group is converted by alkylation or reductive alkylation into a corresponding alkyl compound of general formula I and/or a compound of general formula 1 thus obtained which contains a carboxy or hydroxyphosphoryl group is converted by esterification into a corresponding ester of general formula I and/or a compound of general formula I thus obtained which contains a carboxy or ester group is converted by reaction with a corresponding amine into a corresponding amide of general formula I and/or if necessary any protecting group used during the above reactions is cleaved again and/or if desired a compound of general formula I thus obtained is resolved into its stereoisomers and/or a compound of general formula I thus obtained is converted into the salts thereof, more particularly, for pharmaceutical use, into the physiologically acceptable salts thereof. 6. Process for preparing the compounds of general formula I as claimed in claims 1 to 4, wherein in order to prepare compounds of general formula I wherein the group E is linked to the group D via a nitrogen atom, a compound of general formula Ra Rb A-B-C-D-Z2 , (IV) Rc wherein Ra to Rc, A to D and X are defined as in claims 1 to 3 and Z2 denotes a leaving group such as a halogen atom, a substituted hydroxy or sulphonyloxy group such as a chlorine or bromine atom, a methane sulphonyloxy or p-toluenesulphonyloxy group, is reacted with a compound of general formula H - E' (V) wherein E' denotes one of the groups mentioned for E in claims 1 to 3 which is linked to the group D via a nitrogen atom, while the reaction is carried out in a solvent such as isopropanol, butanol, tetrahydrofuran, dioxane, toluene, chlorobenzene, dimethylformamide, dimethylsulphoxide, methylene chloride, ethylene glycol monomethylether, ethylene glycol diethylether or sulpholane, optionally in the presence of an inorganic or tertiary organic base, e.g. sodium carbonate or potassium hydroxide, a tertiary organic base, e.g. triethyl -amine, or in the presence of N-ethyl-diisopropylamine (Hunig base), whilst these organic bases may simultaneously also serve as solvent, and optionally in the presence of a reaction accelerator such as an alkali metal halide at temperatures between -20 and 150°C, but preferably at temperatures between -10 and 100°C, whereas the reaction may also be carried out without a solvent or in an excess of the compound of general formula V used, and if desired a compound of general formula I thus obtained which contains an amino, alkylamino or imino group is converted by acylation or sulphonylation into a corresponding acyl or sulphonyl compound of general formula I and/or a compound of general formula I thus obtained which contains an amino, alkylamino or imino group is converted by alkylation or reductive alkuyation into a corresponding alkyl compound of general formula I and/or a compound of general formula I thus obtained which contains a carboxy or hydroxyphosphoryl group is converted by esterification into a corresponding ester of general formula I and/or a compound of general formula I thus obtained which contains a carboxy or ester group is converted by reaction with a corresponding amine into a corresponding amide of general formula I and/or if necessary any protecting group used during the above reactions is cleaved again and/or if desired a compound of general formula I thus obtained is resolved into its stereoisomers and/or a compound of general formula I thus obtained is converted into the salts thereof, more particularly, for pharmaceutical use, into the physiologically acceptable salts thereof. Dated this 6th day of December, 2001. [ DIPAK MUNDRA] OF REMFRY & SAGAR ATTORNEY FOR THE APPLICANT

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