Title of Invention

DIHYDROBENZODIAZEPIN-2-ONE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS

Abstract

This invention relates to dihydro-benzo [b] [1, 4] diazepin-2-one derivatives of the general formula: (Formula I); wherein R<sup>1</sup>, R<sup>2</sup>, X and Y are as defined in the specification and R<sup>3</sup> is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide as further defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.

Full Text

Case 21098 Dihydrobenzodiazepin-2-one derivatives IE The present invention relates dihydro-benzo[b] [l,4]diazepin-2-one derivatives of the general formula wherein X " is a single bond or an ethynediyl group; and wherein in case X is a single bond, R1 is hydrogen, cyano, halogen, lower alkyl, lower alkoxy, fluoro-lower alkyl, fluoro-lower alkoxy, pyrrol-1-yl, or phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl; or in case X is an ethynediyl group, R1 is phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl; and wherein R2 is hydrogen, lower alkyl. lower alkenyl lower alkoxy, halogen, pyrrolidin-l-yl, piperidin-1-yi, inorpholme-4-yl, fluoro-lower alkyl, fluoro-lower alkoxy, or lower alkoxy-(ethoxy)m m is 1,2,3 or 4; R' is hydrogen, lower alkyl or C3-6-cydoalkyl; R" is hydrogen, lower alkyl or C3-6-cycloalkyl; Y is -CH= or =N-; R3 is a six-membered aromatic heteroqrde containing 1 to 3 nitrogen atoms or a pyridine-N-oxide, which rings are unsubstituted or substituted by one or two substituents sdected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano> amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, -(CH2)n-C(O)-0R", -(CH2)n-C(O)-NR'R», -(CH2)n-S02-NR'R", - (CH2)n-C(NH2)=NR", hydroxy, lower alkoxy, lower alkylthio, C3-6-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrolidin-l-yl, azetidin-1-yl, cyano or carbamoyloxy, whereby R' and R" have the meaning specified above; n is 0,1,2,3 or 4; and their pharmaceutically acceptable addition salts. It has surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists. Compounds of formula I are distinguished by valuable therapeutic properties. In the central nervous system (CNS) the transmission of stimuli takes place by the interaction of a neurotransmitter, which is sent out by a neuron, with a neuroreceptor. L-glutamic add, the most commonly occurring neurotransmitter in the CNS, plays a critical role in a large number of physiological processes. The glutamate-dependent stimulus receptors are divided into two main groups. The first main group forms ligand-controfled ion channels. The metabotropic glutamate receptors (mGluR) form the second main group and, furthermore, belong to the femily of G-protein-coupled receptors. At present, eight different members of these mGluR are known and of these some even have sub-types. On the basis of structural parameters, the different influences on the synthesis of secondary metabolites and the different aflSnity to low-molecular weight chemical compounds, these eight receptors can be sub-divided into three sub-groups: mGluRl and mGluRS belong to group I, mGluR2 and mGluRS belong to group II and mGluR4, mGluR6, mGluR7 and mGluRS belong to group m. ligands of metabotropic glutamate receptors belonging to the group 11 can be used for the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits. Other treatable indications in this connection are restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest and hypoglycaemia, Further treatable indications are chronic and acute pain, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia caused by AIDS, eye injuries, retinopathy, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate-deficiency functions, such as e.g. muscle spasms, convulsions, migraine, minary incontinence, nicotine addiction, opiate addiction, anxiety, vomiting, dyskinesia and depressions. Objects of the present invention are compounds of formula I and their pharmaceutically acceptable salts per se and as pharmaceutically active substances, their manufacture, medicaments based on a compound in accordance with the invention and their production, as well as the use of the compounds in accordance with the invention in the control or prevention of illnesses of the aforementioned kind, and, respectively, for the production of corresponding medicaments. The compounds of formula I can also be used in form of their prodrugs. Examples are esters, N-oxides, phosphate esters, glycoamide esters, glyceride conjugates and the like. The prodrugs may add to the value of the present compoimds advantages in absorption, pharmacokinetics in distribution and transport to the brain. All tautomeric forms of the compounds of the invention are also embraced herewith. Preferred compounds of formula I in the scope of the present invention are those, in which X is a single bond. Further preferred are compounds of formula I, in which X is a single bond and Y is -CH=, Preferred compounds are those, in which R is pyridyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, fluoro-lower alkyl, fiuoro-lower alkoxy, cyano, amino> lower alkylamino, lower alkoxy-lower alkyiamino, lower hydroxy-lower alkylamino, -(CH2)n-C(O)-OR", -(CH2)n-C(O)-NR'R", .(CH2)n"SO2-NR'R", -(CH2)n-C(NH2)=NR'% hydroxy, lower alkoxy, lower alkylthio, C3-6-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R', hydroxy, lower alkoxy, pyrrolidin-1-yi, azetidin-l-yl, cyano or carbamo)ioxy, and R' and R" are independently from each other selected from hydrogen, lower alkyl or C3-C6'CydodSkyl. A pyridyi residue substituted by one or two lower alkjd groups is especially preferred. A preferred subgroup of these compounds of formula I are those, wherein R1 is hydrogen, halogen, lower alkyl or fluoro-lower alkyl. Especially preferred are compounds of formula I, wherein R3 is pyridyi as defined above and wherein R1 is hydrogen or lower alkyl. The following compounds are examples thereof: 8"methyl-4-(3-pyridin-3-yl-phenyl)-7-trifluoromethyl-l,3-dihydrO" benzo[b] [ l,4]dia2epin-2-one, 8-methyi-4-[3-(2-methyi-pyridin-4-yl)-phenyl]-7-trifluoromethyi-l,3-dihydro benzo[b] [l,4]diazepin-2-one, 4-(3-pyridin-3-yl-phenyl)-7-(2,2,2-trifluoro-ethoxy)-l,3-dihydro-benzo[b] [l,4]dia2epin-2-one, or 4-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl3-8-methyl-7-triflupromethyl-l,3-dihydro benzo[b] [l,4]dia2epin-2-one. Further preferred are compounds of formula I, wherein R is pyridyi as defined above and wherein R1 is halogen. Examples of such compounds are the following: 7,8-dichloro-4-(3-pyridin-3-yl-phenyl)-13-dihydro-benzo[b][l,4]diazepin-2-one, 8-chloro-4- (3-pyridin-4-yl-phenyl)- 1,3-dihydro-benzo [b] [1,4] diazepin-2-one, 8-diloro-4-(3-pyridin-4-yl-phenyl)-l,3-dihydro-benzo[b][l,4]diazepin-2-one, 7,8-dichloro-4-(3-pyridin-4-yl-phenyl)-l,3-dihydro-benzo[b][l,43diazepin-2-one, 8-chloro-7-methyl-4-(3-pyridin-3-yl-phenyl)- 1,3-dihydro-benzo [b] [ 1,4] diazepin-2-one, 8-chloro-4-(3-pyridin-3-yl-phenyl)-l,3-dihydro-benzo[b][l,4]diazepin-2-one, 8-chloro-4- [3-(6-methyl-pyridin-3-yl)-phenyl]-13-dihydro-ben2o[b] [ l,4]dia2epin-2- one, 8-diloro-4- [3- (2-methyl-pyridin-3-yl)-phenyl] -13-dihydro-benzo [b] [1,4] diazepin-2- one, 8-choro-7-methyl-4-(3-pyridin-4-yl-phenyl)-l,3-dihydro-benzo[b][1,4]diazepin-2-one, 7,8-dichloro-4-[3-(2-methyl-pyridm-4-yl)-phenyl]-l,3-dihydro-benzo[1,4]diazepin- 2-one, 8-d3loro-7-methyi-4-[3-(2-me4yl-pyridin-4-yl)-phenyl]-13-dihdro ben2o[b] [l,4]diazepin-2-one, 8-fluoro-4-[3-(2-metiiyi-pyridin-4-yl)-phenyl]-13-dibydro-benzo[1,4]diazepin-2- one, 8-chloro-4-[3-(2-metiiyl-pyridin-4-yl)-phenyl]-7-trifluoromethyl-1,3-dihydro benzo[b] [l,4]diazepin-2-one, 8- beii2o[b][l,4]diazepin-2-one, or 7,8-dicWoro-4-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-l,3-dihy benzo[b] [l,4]diazepin-2-one. Also preferred are compounds of formula I, wherein R3 is pyridyl as defined above and wherein R1 is trifluoromethyl. The following compounds are examples thereof. 7-dimethylamino-4-(3-pyridin-3-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo[b] [l,4]dia2epin-2-one, 7-dimethyiamino-4-(3-pyridin-4-yl-phenyl)"8-trifluoromethyl-l,3-dihydro-benzo[b] [l,4]diazepin-2-one, 4-(3-pyridin-4-yl-phenyl)-8-1xifluoromethyl-l,3-dihydro-benzo[b][l,4]dia2epin-2-one, 4-(3-pyridin-3-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo[b][l,4]diazepin-2-one 4-(3-pyridin-3-yl-phenyl)-7-(2,2,2-trifiuoro-ethoxy)-8-1xifluoromethyl-l,3-dihydro benzo[b] [l,4]diazepin-2-one, 7-ethoxy-4-(3-pyridin-4-yl-phenyl)-8-txifLuoromethyl-l,3-dihydro-benzo [b] [ 1,4] diazepin-2-one, 4-(3-pyridin-4-yl-phenyl)-7- (2,2,2-trifluoro-ethoxy)-8-trifluoromethyl- 1,3-dihydro-benzo[b] [l,4]diazepin-2-one, 7-methyl-4-(3-pyridin-4-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo [b] [ 1,4] diazepin-2-one, 8-methyl-4-(3-pyridin-4-yl-phenyl)-7-trifluoromethyi-l,3-dihydro-benzo[b] [l,4]diazepin-2-one, 7-chloro-4- (3-pyridin-4"yl-phenyl)-8-trifluoromethyl- 1,3-dihydro- Anotiier preferred subgroup of compounds of formula I, wherein R3 is pyridyl as defined above, are those compounds, wherein R1 is pyrrol-l-yl or phenyl, which is unsubstituted or substituted by one or two substituents selected firom the group consisting of halogen, lower alkyl or fluoro-lower alkyL The following compounds are examples thereof: 8-(2-fluoro-phenyl)-4-[3-(2-methyl-pyridin-3-yi)-phenyl]-l,3-dihydro-benzo[b] [1,4] dia2epin-2-one, 8-(2-fluoro-phenyl)-4-(3-pyridin-4-yl-phenyl)-l,3-dihydro-benzo[b][l,4]diazepin-2-one, 8-(2-fiuoro-phenyl)-4-(3-pyridm-3-yl-phenyl)-13-dihydro-beiizo|>][l,4]diazepm-2-one, or 8-(2-fluoro-phenyl)-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-l,3-dihydro-benzo[b] [1,4] diazepin-2-one- Further preferred are compounds of formula I, wherein R is pyridyl as defined above, and wherein R1 is fluoro-lower alkoxy. An example of such a compound is 4- [3-(2"methyl-pyridin"4-yl)-phenyl] -8-trifluoromethoxy-l,3-dihydro-benzo[b] [l,4]diazepin-2-one. Further preferred compounds of formula I are those, wherein R3 is pyrazinyi, which is unsubstituted or substituted by one or two substituents selected firom the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower aDcylamino, -(CH2)n" C(O)-OR", -(CH2)n-C(O).NR'R", -(CH2)n-SO2-NR'R", .{CH2)n-C(NH2)=NR", hydroxy, lower alkoxy, lower alkylthio, C3-C6-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrolidin-l-yl, azetidin-1-yl, cyano or carbamoyloxy, and wherein R' and R" are independently from each other selected from hydrogen, lower alkyl or C3-C6-cydoalkyl. Examples of such compounds are the following: 8-chloro-7-methyl-4-(3-pyra2in-2-yl-phenyl)-l,3-dihydro-ben2o[b][l,4]diazepin-2-one, 7-methyl-4-(3-pyrazin-2-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo[b][l,4]dia2epin-2-one, or 7-(methyl-propyl-amino)-4-(3-pyrazin-2-yl-phenyl)-8-trifluoromethyl-13-dihydro-benzo[b] [l,4]diazepin-2-one, •J Also preferred are compounds of formula I, wherein R is pyrimidinyl or pyridazinyl, which are unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxjr, qrano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxjr-lower alkylamino, -(CH2)n-C(O)-0R", -(CH2)n-C(O)-NR'R", -(CH2)n-SO2-NR'R", -(CH2)n-C(NH2)=NR", hydroxy, lower alkoxy, lower alkjdthio, C3-C6-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxyl, lower alkoxy, pyrrolidin-l-yl, azetidin-l-yl, cyano or carbamoyloxy, and R' and R" are independently from each other selected from hydrogen, lower alkyl or C3-6-cydoalkyl. The following are examples of sudi compounds: 8-chloro-7-methyl-4- (3-pyridazin-4-yl-phenyl)- 1,3-dihydro-benzo [b] [1,4] dia2epin-2-one, 7-methyl-4-(3-pyrida2in-4-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo[b] [l,43diazepin-2-one, 8-(2-fiuoro-phenyl)-4-(3-pyrimidin-5-yi-phenyl)-l,3-dihydro-ben2o[b][l,4]diazepin-2-one, or 4-[3-(6-methyl-pyrimidin-4-yl)-phenyl]-8-trifluoromethyl-1,3-dihydro-benzo[b] [1,4] diazepin-2"One Further preferred are compounds of formula I, wherein R is a pyridine-N-oxide, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylaimino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, "(CH2)ii-C(O)"OR", -(CH2VC(O)-NR'R", -(CH2)n-SO2-NR'R", -(CH2)n-C(NH2)=NR", hydroxy, lower alkoxy, lower alkylthio, C3-6-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrolidin-l-yl, azetidin-1-yl, cyano or carbamoyloxy, and R' and R" are independently from each other sdected from hydrogen, lower alkyl or C3-C6-cydoalkyl. Compounds of formula I, wherein Y is -N=, are also preferred. The following compounds are examples thereof: 4-[2,3']bipyridinyi-4-yl-7-methyl-8-trifluoromethyl-13-dihydro-benzo[b][l,4]diazepin-2-one, or 7-methyl-4-(2'-methyi-[2,4]bipyridinyl-4-yl)-8-trifluoromethyyH,3-dihydro-benzo [b] [ 1,4] diazepin-2-one. Unless otherwise stated, the following terms used in the present description have the definitions given in the following. The term 'lower alkyl" denotes straight-chain or branched saturated hydrocarbon residues with 1 to 7 carbon atoms, preferably with 1 to 4 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl and the like. The term 'lower alkenyl" denotes sixaight-chain or branched unsaturated hydrocarbon residues -with 2 to 7 carbon atoms, preferably with 2 to 4 carbon atoms, such as ethenyl or propenyi. The term "lower alkoxy" denotes a lower alkyl residue in the sense of the foregoing definition bound via an oxygen atom. Examples of'lower alkoxy" residues indude methoxy, ethoxy, isopropoxy and the like. The term 'lialogen" embraces fluorine, chlorine, bromine and iodine. The term "fluoro-lower alkyl" means a lower alkyl residue, wherein one or more hydrogen atoms are replaced by fluorine, for example trifluoromethyl. Accordingly, the term "fluoro-lower alkoxy" denotes a lower alkoxy residue as defined before, wherem one or more hydrogen atoms are replaced by fluorine. "Lower aIkoxy-(ethoxy)m" (m is 1,2,3 or 4) denotes a lower alkoxy residue in the sense of the foregoing definition bound via 1 to 4 -CH2-CH2-O- groups, for example 2-methoxy-ethoxy. The term "C3-6-cycloalkyl" means a cydoalkyl group containing 3 to 6 carbon atoms, such as cyclopropyl, cydobutyl, cydopentyl or cydohexyi. The term "alkylthio" denotes a lower alkyl residue in the sense of the foregoing definition botmd via an sulfur atom, for example methylsulfanyl- "Carbamoyloxy" means the group -O-CO-NH2. The expression "six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms" means a six-membered heteroaryl group sdected from the group consisting of pyridine, pyridazine, pyrimidine, pyrazine and triazine. "Pyridine-N-oxide" or "pyridine-1-oxide" means a compound having the following formxila: The term "pharmaceutically acceptable addition salt" refers to any salt derived from an inorganic or organic add or base. The compounds of general formula I and their pharmaceutically acceptable salts can be manufactured according to a process, which comprises and, if desired, converting the compound obtained into a pharmaceutically acceptable add addition salt In more detail, according to scheme A, compounds of general formula I, in which X,Y,R1R2 and R3 are as described above, can be prepared from compounds of general2 formula II via an acylation-deprotection-cydization sequence: Reacting compounds of general formula 11 with a dioxinone IV, in which Y and R are as described above, in an inert solvent such as toluene or xylene at elevated temperatures, preferably between 80 °C and 160 °C, gives rise to compounds of general formula EI, Alternatively, compounds of general formula III can also be prepared by for example reaction of a compound of general formula 11 with a P-ketoester (general i formula IVa), in which Y and R are as described above, using the same conditions as described for the reaction with the dioxinones. Afterwards, cleaving the BOC (tert-butoxycarbonyl) protecting group in compounds of general formula HI and concomitant cydization of the deprotected compound yidds the desired compounds of general formula L Any other suitable amino protecting group, such as e.g. Fmoc (9-fluorenylmethoxycarbonyl) or ben2yloxycarbonyl (Z), can be alternatively used instead of the BOC group. The deprotection-cyclization step can be carried out by treating the compounds of general formula III with for example a Bronsted add such as trifluoroacetic add in an inert solvent such as dichloromethane (DCM). The reaction is preferably carried out at temperatures between 0 °C and 50 °C. It may be advantageous to use also anisole or 1,3-dimethoxybenzene as a carbocation scavenger in the reaction mixture. Compounds of general formula II, in which R1 R2 and X are as described above can be prepared according to scheme B, by reducing the nitro group in compounds of general formula Via to the amino group. The reduction can for example be carried out using hydrogen gas in presence of a suitable catalyst like for example Raney-Nickel or Pafladium on carbon. Another possible reduction method is using stannous(n)chloride (SnCl2*2H20) in ethanol at temperatures between 70 °C and 80 °C (as described in Tetrahedron Lett. 1984,25y 839), or alternatively in polar aprotic solvents, like DMF, DMA or NMP and the like, optionally in the presence of bases> like for example pyridine or triethylamine and the like, at temperatures between 0 °C and 80 °C. Another suitable method is using zinc-powder in the presence of ammonium chloride in protic solvents like for example water or ethanol at temperatures between 20 °C and 80 °C. The exact conditions for the respective compounds of general formula 11 can be found in the experimental part The protection of the amino function can be applied to a number of commercially available starting materials or compounds synthesized by anyone skilled in the art to produce the corresponding 2-mtroanilines with the general formula VI, in which X is a single bond and R1 is as described above. As described in scheme C, compounds of the general formula Via, in which R1 is as described above, R is chloro, fluoro or substituted oxygen and R' is hydrogen, can be prepared by protection of the amino group of compounds of the general formula Vila, in which R1 is as described above, R is chloro, fluoro or substituted oxygen and R' is hydrogen, with a tert-butoxycarbonyl-group (BOC). One possibility for the protection of the amino function is for example reacting compounds of general formula VIIa with di-tert-butyl-carbonate in the presence of abase such as cesium carbonate. The reaction can be carried out in polar solvents such as acetone or butanone and the like at temperatures between 20 °C and 80 °C Alternatively, the protection of the amino group can be achieved by preparing the intermediate isocyanate by treatment of compounds of the general formula Vila, in which R1 is as described above, R is chloro, fluoro or substituted oxygen and R' is hydrogen, with diphosgene, preferably in aprotic solvents such as EtOAc or 1,4-dioxane at temperatures from 0 °C to 100 °C, and subsequent treatment of the isocyanate with tert-butanol in solvents such as dichloromethane or 1,2-dichloroethane and the like at temperatures between 20 °C and 85 °C to give the desired compounds of general formula Via. Another suitable method to achieve this protection step is the intermediate formation of a di-BOC compound by treatment of compounds of the general formula Vila, in which R1 is as described above, R is chloro, fluoro or substituted oxygen and R' is hydrogen, with di-tert-butyi-carbonate in the presence of DMAP in an aprotic solvent such as tetrahydrofuran and the like, followed by selective removal of a single BOC-group by treatment with a Bronsted-add, like e.g TFA, in aprotic solvents such as dichloro-methane, chloroform or 1,2-dichloroethane at temperatures between 0 °C and 20 °C to give the desired compounds of general formula Via. Yet another suitable method to produce compounds of general formula IXa is the intermediate formation of a N-Ac-BOC compound by treatment of compounds of the general formula VTIa, in which R1 is as described above, R is chloro or fluoro and R' is acetyl, with di-tert-butyl-carbonate in the presence of DMAP in an aprotic solvent such as tetrahydrofuran and the like, followed by selective removal of a single BOC-group by treatment with a Bronsted-base, like e.g. aqueous ammonia (NH4OH), in aprotic solvents such as tetrahydrofuran, diethyiether or 1,4-dioxane and the like, at temperatures between 0 °C and 20 °C to give the desired compounds of general formula Via. Apparently, the protection of the amino function as shown in scheme C can be applied to a number of commercially available starting materials or compounds synthesized by standard transformations [e,g. nitration followed by selective ammonolysis of the halide in ortho-position to the newly introduced nitro-group as described in /. Med. Cherru 1994,37, 467; or ortho-nitration of acetanilide-compounds followed by deacetylation with for example aqueous potassium hydroxide solution or aqueous hydrochloric add as described in Org. Synth. 1945,25,78 or in /. Med. Chem. 1985,28,1387] known to anyone skilled in the art to produce the corresponding 2-nitroanilines with ihe general formula Vila, in which R1 is as described above, R is chloro or fluoro and R' is hydrogen, or 2-nitroacetanilides with the general formula DCa, in which R1 is as described above, R is chloro or fluoro and R' is acetyl. The exact conditions for the respective compounds used in this invention can be found in the experimental part. According to scheme D, compounds of general formula n in which R^ is phenyl optionally substituted as described above for compounds where X is a single bond and R is as described above, can be prepared by different routes depending on the nature of R1 from the iodo-compounds of general formula V, in which R2 is as described above. As shown in scheme D, the key step is a coupling reaction of Suzuki-type to produce compounds of the general formula Vlb. Compounds of general formula V, in which R is as described above, can be prepared by different routes depending on the individual residue R2. For example, a compound of formula V wherein R is CI, can be prepared from the commercially available 5-chloro-2-nitroaniline by iodination using iodine monochloride in acetic add in the presence of sodium acetate at temperatures between 20 °C and 80 °C to give 5-chloro-4-iodo-2-nitroaniline, which in turn can be protected to yield a compound of formula V wherein R isCL According to scheme E, compounds of general formula VIIb, in which R1 is pyrrol-1-yl, X is a single bond and R is chloride, can be prepared from known 5-chloro-2-nitro-1,4-phenylenediamine [CAS-No. 26196-45-2] by selective condensation of the 4-amino-group with a suitable substituted 2,5-dimethoxy-tetrahydrofuran of the general formula VIII, as described in /. Heterocycl Chenu 1988,25,1003. The reaction is preferably carried out in addic media, like for example acetic add or propionic add and the like, at temperatures between 40 °C to 100 °C. The exact conditions for the respective compounds can be found in the experimental part As shown in scheme F, compounds of general formula Vic, in which R2 is -NR'R", wherein R' and R" are hydrogen, lower alkyl or C3-6-cydoalkyl, or form a pyrrolidin-1-yl, piperidin-1-yi, or morpholine-4-yl, can be prepared from the intermediate compounds with the general formula Vic - which individual synthesis can be found in the e3q)erimental part - by a nudeophilic substitution reaction with the respective amines in the presence of a suitable base. The reaction is preferably carried out in a polar, aprotic solvent such as dimethyl formamide, N-methyl-pyrrohdone or dimethyl sulfoxide and the like. The base can be selected from the sterically hindered amines such as triethylamine or Hiinig's base, alkoxides such as sodium methoxide and tert-butoxide, or hydrides such as sodium hydride. The reaction can be performed at temperatures between 20 °C and 110 °C, depending on the individual compounds to be synthesized. According to scheme G, compounds of general formula II in which R1 is as described above for compounds where X is an ethynediyl group can be prepared by different routes from the iodo-compounds V, depending on the nature of R and R • As shown in scheme F, the transformation can for example be carried out a) by direcfly attaching the R1-alkynediyl-substituent to a compound of general formula V via a Sonogashira-type coupling to produce compounds of the general formula VId followed by the reduction of the nitro group, or b) by two stepwise Sonogashira-type couplings, in which first trimethylsiiyl-acetylene is coupled to a compound of general formula V to yidd, after desilylation with sodium hydroxide in methanol, the intermediate X which then can be transformed via a second Sonogashira-type coupling with the appropriate reactant R1-I, R1-Br or R1-OSO2CF3 into compounds of the general formula VId and reduction of the nitro group leads to the desired compounds of general formula IL The exact conditions for the respective compounds can be found in the experimental part According to Scheme H, the dioxinones and b-keto esters building blocks with the general formula IV and IVa can be prepared by methods known to someone skilled in the art from the corresponding carboxylic add derivatives R3-R, i.e. free acids, methyl or ethyl esters, acid chlorides and nitriles- The exact conditions for the corresponding compounds can be found in the experimental part. The phannaceutically acceptable addition salts can be manufactured readily according to methods known per se and taking into consideration the nature of the compound to be converted into a salt Inorganic or organic adds such as, for example, hydrochloric acid, hydrobroroic add, sulphuric add, nitric add, phosphoric add or dtric add, formic add, fumaric add, maldc add, acetic add, succinic add, tartaric add, methanesulphonic add, p-toluenesulphonic add and the like are suitable for the formation of pharmaceuticafly acceptable salts of basic compounds of formula I. The compounds of formula I and their pharmaceutically acceptable salts are metabotropic glutamate receptor antagonists and can be used for the treatment or prevention of acute and/or chronic neurological disorders, such as psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits. Other treatable indications are restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregancy, cardiac arrest and hypoglycaemia. Further treatable indications are acute and chronic pain, Himtington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate-defident functions, such as e.g. musde spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, dyskinesia and depression. The compounds of formula I and pharmaceutically acceptable salts thereof can be used as medicaments, e.g. in the form of pharmaceutical preparations. The pharmaceutical preparations can be administered orally, e.g. in the form of tablets, coated tablets, dragees, hard and soft gelatine capsules, solutions, emulsions or suspensions. However, the administration can also be effacted rectally, e.g. in the form of suppositories, or parenterally, e.g. in the form of injection solutions. The compounds of formula I and pharmaceutically acceptable salts thereof can be processed with pharmaceutically inert, inorganic or organic carriers for the production of pharmaceutical preparations. Lactose, com starch or derivatives thereof, talc, stearic add or its salts and the like can be used, for example, as such carriers for tablets, coated tablets, dragees and hard gelatine capsules. Suitable carriers for soft gelatine capsules are, for °Cample, vegetable oils, waxes, fats, semi-solid and liquid polyols and the like; depending on the nature of the active substance no carriers are, however, usually required in the case of soft gelatine capsules. Suitable carriers for the production of solutions and syrups are, for example, water, polyols, sucrose, invert sugar, glucose and the like. Adjuvants, such as alcohols, polyols, glycerol, vegetable oils and the like, can be used for aqueous injection solutions of water-soluble salts of compounds of formula I, but as a rule are not necessary. Suitable carriers for suppositories are, for example, natural or hardened oils, waxes, fats, semi-liquid or liquid polyols and the like. In addition, the pharmaceutical preparations can contain preservatives, solubilizers, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances. As mentioned earlier, medicaments containing a compound of formula I or a pharmaceutically acceptable salt thereof and a therapeutically inert excipient are also an object of the present invention, as is a process for the production of such medicaments which comprises bringing one or more compounds of formula I or pharmaceutically acceptable salts thereof and, if desired, one or more other therapeutically valuable substances into a galenical dosage form together with one or more therapeutically inert carriers. The dosage can vary within wide limits and will, of course, be fitted to the individual requirements in each particular case. In general, the effactive dosage for oral or parenteral administration is between 0.01-20 mg/kgday, with a dosage of 0.1-10 mg/ kg/day being preferred for all of the indications described. The daily dosage for an adult human being weighing 70 kg accordingly lies between 0.7-1400 mg per day, preferably between 7 and 700 mg per day. The present invention relates also to the use of compounds of formula I and of pharmaceutically acceptable salts thereof for the production of medicaments, especially for the control or prevention of acute and/or chronic neurological disorders of the aforementioned kind. The compounds of the present invention are group II mGlu receptor antagonists. The compotmds show activities, as measured in the assay described below, of 0.060 ^M or less, typically 0.025 ^M or less, and ideally of 0,010 jiM or less. In the table below are described some specific Ki values of preferred compounds. 3[H] -LY354740 binding on mGlii2 transfacted CHO cell membranes. Transection and cell culture cDNA encoding the rat mGlu2 receptor protein in pBluescript II was subdoned into the eukaryotic expression vector pcDNA I-amp from Invitrogen (NV Leek, The Netherlands). This vector construct (pcDlmGR2) was co-transfacted with a psvNeo plasmid encoding the gene for neomycin resistance, into CHO cells by a modified calcium phosphate method described by Chen & Okayama (1988). The cells were maintained in Dulbecco's Modified Eagle medium with reduced L-glutamine (2 mM final concentration) and 10 % dialysed foetal calf serum from Gibco BRL (Basel, Switzerland). Selection was made in the presence of G-418 (1000 ug/ml final). Clones were identified by reverse transcription of 5 µg total RNA, followed by PCR using mGlu2 receptor specific primers 5'-atcactgcttgggtttct°Cactg-3' and 5'-agcatcactgtgggggcataggagc-3' in 60 mM Tris HQ (pH 10), 15 mM (NH4)2S04,2 mM MgQ2,25 units/ml Taq Polymerase with 30 cydes annealing at 60 °C for 1 min., extention at 72 °C for 30 s, and 1 min. 95 °C denaturation. Membrane preparation Cells, cultured as above, were harvested and washed three times with cold PBS and firozen at -80 °C, The pellet was resuspended in cold 20 mM HEPES-NaOH buffer containing 10 mM EDTA (pH 7.4), and homogenised with a polytron (Kinematica, AG, Littau, Switzerland) for 10 s at 10 000 rpm. After centrifugation for 30 min. at 4 '°C, the pellet was washed once with the same buffer, and once with cold 20 mM HEPES-NaOH buffer containing 0.1 mM EDTA, (pH 7.4). Protein content was measured using the Pierce method (Socodiim, Lausanne, Switzerland) using bovine serum albumin as standard. [^H]-LY354740 binding After thawing, the membranes were resuspended in cold 50mM Tris-HCl buffer containing 2 mM MgCl2 and 2 mM CaCl2, (pH 7) (binding buffer). The final concentration of the membranes in the assays was 25µg protein/ml. Inhibition experiments were performed with membranes incubated with 10 nM [3H]-Ly354740 at room temperature, for 1 hour, in presence of various concentrations of the compound to be tested. Following the incubations, membranes were filtered onto Whatmann GF/C glass fiber filters and washed 5 times with cold binding buffer. Non specific binding was measured in the presence of 10 µM DCGIV. After transfer of the filters into plastic vials containing 10 ml of Ultima-gold scintillation fluid (Packard, Zurich, Switzerland), the radioactivity was measured by liquid scintillation in a Tri-Carb 2500 TR counter (Packard, Zurich, Switzerland). Data analysis. The inhibition curves were fitted with a four parameter logistic equation giving IC50 values, and Hill coefficients, EXAMPLES General procedure A Method a (from 2-nitrnani1inP5;)! To a solution of diphosgene (4.1 mL, 34.1 mmol) in EtOAc (40 mL) at 0 was added a solution of the 2-nitroaniline (45.5 mmol) in EtOAc (200-500 mL), and the mixture was heated to reflux for 18 h. The solvent was removed in vacuum to leave a brown solid, which was triturated with hot hexane (200 mL), The solid material was filtered off and the filtrate was concentrated under reduced pressure to leave the pure 2-nitrophenyl disocyanate as a yellow solid. This material was refluxed in a mixture of excess tert-BuOH in CH2CI2 for 2.5 h. Removal of the solvent left an orange solid which was purified by silica gel column chromatography with hexane/EtOAc to give the (2-nitro-phenyi)-carbamic add tert-butyl ester as a yellow solid. Method b (from 2'nitroanilines): To a mixture of the 2-mtroaniline (142 mmol) and cesium carbonate (55.5 g, 170 mmol) in 2-butanone (740 mL) was dropwise added a solution of B0C2O (37.8 g, 173 mmol) in 2-butanone (170 mL) and the resulting mixture was stirred at 50 °C to 80 °C until tic indicated complete conversion. The solvent was removed in vacuum, the residue was treated with a mixture of H2O (240 mL) and MeOH (240 mL) and extracted with hexane (3 x 500 mL). The combined hexane layer was washed with brine (200 mL) and all aqueous layers were reextracted with hexane (300 mL). All combined hexane layers were dried over MgSO4, filtered and the solvent was removed in vacuum to give an orange solid, which was purified by silica gel column chromatography with hexane/EtOAc to give the (2-nitro-phenyl)-carbamic add tert-butyl ester as a yellow solid. Method c (from 2-nitroanilines'): To a solution of the 2-nitroaniline (550 mmol) and DMAP (1.22 g, 10 mmol) in THF (1000 mL) at 23 °C was dropwise added within 70 min a solution of B0C2O (246 g, 1128 mmol) in THF (500 mL) and stirring was continued at 23 °C for 75 min. The entire mixture was evaporated to dryness and dried at HV to leave a darlc brown solid. This material was dissolved in DCM (1100 mL), cooled to 0 °C and TFA (84 mL, 1100 namol) was added dropwise. The mixture was stirred at 0 °C for 2 h, poured into icecold sat NaHCOs-solution, extracted with DCM, washed witii brine and dried over MgSO4. Removal of the solvent in vacuum left a dark brown solid which was coated on silica gel and purified by silica gel column chromatography "with hexane/EtOAc to give the (2-nitro-phenyl)-cafbamic acid tert-but)i ester as a yellow solid. Method d f from 2-nitroacetanilides'): To a solution of the 2-nitroacetanilide (100 mmol) and DMAP (122 mg, 1 mmol) in THF (100 mL) at 23 °C was dropwise added within 15 min a solution of BocaO (22.92 g, 105 mmol) in THF (100 mL) and stirring was continued at 23 °C until tic indicated completed conversion. The entire mixture was evaporated to dryness and dried at HV to leave a yellow to dark brown solid. This material was dissolved in THF (200 mL) and 25 % NH4OH (77 mL, 500 mmol) was added dropwise. The mixture was stirred at 23 °C until tic indicated complete conversion, poured into IN HCl-solution, extracted with EtOAc, washed the organic layer with sat. NaHCOs-solution and brine, dried over MgSO4. Removal of the solvent in vacuum left an yellow to brown solid which was generafly pur-e enough for futher transformation or - if necessary - coated on silica gd and purified by silica gel column chromatography with hexane/EtOAc to give the (2-nitro-phenyl)-carbamic acid tert-butyl ester as a yellow solid. Example Al (5-ChlorO"2-nitro-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compotmd was prepared via the di-Boc-compound from commercially available 5-chloro-2-nitro-4-trifluoromethyi-phenylamine [CAS-No. 35375-74-7] (22.61 g, 94 mmol) and B0C2O (42.06 g, 193 mmol), followed by treatment with 2 eq, TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (31.82 g, 99 %)• MS (ISN) 339.1 [(M-H)"] and 341 [(M+2-H)"]; mp 113-115 X. Example A2 f 5-Fluoro-2-nitro-4-trifluoromethvl-phenvD-carbamic add tert-butyl ester The title compoxmd was prepared via the di-Boc-compound from 5-fluoro-2-nitro-4" trifluoromethyl-phenylamine [which was prepared from commercially available 4-amino-2-fluorobenzotrifluoride by acetylation with AC2O in toluene at 23 °C, followed by nitration with 100 % nitric add from 10-23 °C and deacetylation with 2N NaOH in THF at 50 °C] (5.21 g, 23.2 mmol) and B0C2O (10.63 g, 48.7 mmol). After treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c) (5-fluoro-2-nitro-4-trifluoromethyl-phenyl)-carbanic add tert-butyl ester was obtained as a light yellow solid (6.33 g, 84 %). mmol) and B0C2O (30.38 g, 139,2 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (17,06 g, 86%). MS (ISN) 289.0 [(M-H)-] and 291 [(M+2-H)-]; mp 72-73 °C Example A7 [2-Nitro-5-f2J2.2-trifluoro-ethoxy)-4-trifluoromethyl-phenyll-carbamic acid tert-butyl ester The title compound was prepared via the di-Boc-compound from 2-mtro-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenylamine [prepared by stirring commercially available 5-chloro-2-nitro-4-trifluoromethyl-phenylamine [CAS-No. 35375-74-7], 2,2,2-trifluoroethanol and KOH in DMSO at 23 °C for 32.5 days] and B0C2O, followed by treatment with 2 eq. TFA in CH2Q2 according to the general procedure A (method c). Obtained as a yellow solid (18.955 g), MS(ISN)403[(M-H)"]. Example A8 (5-Methoxy-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (5-Methoxy-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester was prepared via the di-Boc-compound from 5-methoxy-2-nitro-4-trifluoromethyl-phenylamine [prepared by stirring commercially available 5-diloro-2-nitro-4-trifluoromethyl-phen)damine [CAS-No. 35375-74-7], methanol and KOH in DMSO at 23 °C for 10 days] (4.14 g, 17.5 mmol).and B0C2O (8.04 g, 36.8 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (5,86 g). MS (ISN) 335 [(M-H)-]; mp 68 °C. Example A9 f5-ethoxy-2-nitro-4-trifluorometfayl-phenyl)-carbamic acid tert-butyl ester The title compound was prepared via the di-Boc-compound from 5-ethoxy-2-nitro-4-trifluoromethyl-phenylamine [prepared by stirring commercially available 5-chloro-2-nitro-4-trifluoromethyl-phenylamine [CAS-No. 35375-74-7], ethanol and KOH in DMSO at 60 °C for 7 days] (4.16 g, 16.6 mmol).and B0C2O (7.62 g, 34.9 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (5.54 g). MS (ISN) 349 [(M-H)-]; mp 67 °C Example AlO (4-Methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester The title compound was prepared via the di-Boc-compound from commercially available 4-methoxy-2-mtroaniline [CAS-No. 96-96-8] and B0C2O, followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c)- Obtained as an orange solid (21.868 g). MS (ISN) 268.2 [(M-H)']; mp 53 °C Example All (2-Nitro-4-pyrrol-l-yl-phenyl)-carbamic acid tert-butyl ester (2-Nitro-4-pyrrol-l-yl-phenyl)-carbamic add tert-butyl ester was prepared via the di-Boc-compound from 2-nitro-4-pyrrol-l-yl-phenylamine (Example Fl) (13.5 g, 66.4 mmol) and B0C2O (30.45 g, 139 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (16.0 g, 79 %). MS (ISN) 302 [(M-H)-]. Example A12 ( 5-Methoxy-2-nitro-phenyl)-carbamic add tert-butyl ester The title compound was prepared the di-Boc-compound from 5-methoxy-2-nitro-phenylamine [CAS-No, 16133-49-6] (7.73 g, 46 mmol) and B0C2O (20.60 g, 94.3 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (12.234 g). MS (EI) 268.2 (M+); mp 109-112 °C Example A13 f2-Nitro-5-f2^^-1xifluoro*ethoxyVphenyl1-carbainic add tert-butyl ester The title compound was prepared via the di-Boc-compound from 2-iiitro-5"(2,2,2-trifluoro-ethoxy)-phenylamine [CAS-No. 57925-48-1] [prepared by stirring commercially available 5-chloro-2-iutro-plienylaiiiine [CAS-No. 1635-61-6] > 2,2,2-trifluoroethanol and KOH in DMSO at 60 °C for 7 days] (11.0 g, 46.6 mmol) and B0C2O (21.35 g, 97.8 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (16.052 g), MS(ISN)403[(M-Hr]. Example A14 f 5-Ethoxy-2-nitro-phenyl)-carbamic add tert-butyl ester (5-Ethoxy-2-nitro-phenyl)-carbamic add tert-butyl ester was prepared via the di-Boc-compound from 5-ethoxy-2-nitro-phenylamine [CAS-No. 27076-16-0] [prepared by stirring commerdally available 5-chloro-2-nitro-phenylamine [CAS-No. 1635-61-6], ethanol and KOH in DMSO at 60°C for 7 days] (7.78 g, 42.7 mmol) and B0C2O (19.57 g, 89.7 imnol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (8.71 g). MS (ISN) 281 [(M-H)-]; mp 98 °C. Example A15 (5-Methyl-2-nitro-4-trifluoromethvl-phenylVcarbamic add tert-butyl ester To a suspension of (5-chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example Al) (5.00 g, 14.7 mmol), tetrakis(triphenylphosphine)panadium (1.70 g, L47 mmol) and potassitmi carbonate (6.09 g, 44.1 mmol) in dioxane/water (9:1; 50 ml) was added at RT trimethylboroxine (2.04 ml, 14.7 rmnol). The reaction mixture was stirred under reflux conditions for 15h, filtered, evaporated and purified by column chromato-graphy on silica gel (hexane/ethyl acetate 9:1) to yield a light yellow solid (3.25 g, 69%). MS (ISP) 319.2 [(M-H)-]. Example A16 ( 4-CMoro-5-methyl-2-nitro-phenyl-carbamic acid tert-butyl ester To a suspension of (4,5-dichloro-2-nitro-phenyl)-carbamic acid terL-butyl ester (Example A20) (10,0 g, 32.6 nunol), tetrakis(triphenylphospliine)palladium (3.76 g, 3.26 mmol) and potassium carbonate (13.5 g, 97.7 mmol) in dioxane/water (9:1; 100 ml) was added at RT trimethylboroxine (4.53 ml, 32.6 mmol). The reaction mixture was stirred imder reflux conditions for 15h, filtered, evaporated and purified by coliunn chromatography on silica gd (hexane/ethyl acetate 19:1) to yidd a light ydlow solid (4.45 g, 48%). MS (ISP) 285.0 [(M-H)-]. Example A17 (5°Chloro-4-methyl-2-nitro-phenyl-carbamic add tert-butyl ester Hie tide compound was prepared via the di-Boc compound from commerdally available 5-chloro-4-methyl-2-nitroaniline (10.0 g, 53.6 mmol) and B0C2O (23.9 g, 109 mmol), followed by treatment with 2 eq, TFA in CH2Q2 according to the general procedure A (method c). Obtained by column chromatography (toluene/ethylacetate 19:1) as a ydlow solid (14.6 g, 95%). MS (ISN) 285.1 [(M-H)-]. Example A18 (4-Methvl-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester a)N-(4-Methyl-3-trifluoromethyl-phenyl)-acetamide Acetylation of commerdally available 4-me1iiyl-3"trifluoromethyl-aniline (10 g, 57.1 mmol) with acetic add anhydride in toluene at RT gave N-(4-methyl-3-trifluoromethyl-phenyl)-acetainide (11.9 g, 96%) as a white solid; mp lOlX [CAS 22957-86-4]. b)N"(4-Methyl"2-nitro-5-trifluoromethyl-phenyl-)-acetamide Nitration of N-(4-methyl-3-trifluoromethyl-phenyl)-acetamide (11.6 g, 53.5 mmol) in acetic add anhydride gave a mixture of N-(4-methyl-2-nitro-5-trifluoromethyl-phenyl)-acetamide andN-(4-methyl-2-nitro-3-trifluoromethyl-phenyl)-acetaimde. Separation of this mixture by column chromatography on silica gd (hexane/ethyl acetate 2:1) yidded N-(4-methyl-2-nitro-5-trifluoromethyl-phenyl)-acetainide (5.2 g, 37%) as a ydlow solid. c) (4-methyl-2-rdtro-5-trifluorometliyl-phenyl)-carbamic add tert-bulyl estex Reaction of N-(4-methyl-2-nitro-5-trifluoromethyl-phenyl)-acetanide (5.0 g, 19.1 mmol) with Boc-anhydxide (4.37 g, 20.0 mmol) according to the general procedure A (method d) and subsequent reaction -with ammonium hydroxide (25%; 5.87 nd, 38.1 romol) gave after aqueous work up and purification by column chromatography on silica gd (herane/eth)d acetate 4:1) (4-methyl-2-nitro-5-trifluorometliyl-phenyl)-carbai3aic acid tert-butyi ester (4.84 g, 79 %) as a yellow solid. MS (ISP) 319.2 [(M-H)-]. Example A19 ( 4-Chloro-2-nitro-5-trifluoromethyl-phenyl)-carhamic acid tert-butyl ester Reaction of N-(4-chloro-2-nitro-5-trifiuoromethyl-phenyl)-acetamide [CAS 157554-77-3] (4.02 g, 14-2 mmol) with Boc-anhydride (3.26 g, 14.9 mmol) according to the general procedure A (method c) and subsequent reaction with ammonium hydroxide (25%; 4,38 ml, 28.4 mmol) gave after aqueous work up and purification by column chromatography on silica gel (hexane/ethyl acetate 4:1) (4-chloro-2-nitro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyi ester (3.39 g, 70 %) as an orange oil. MS (ISP) 339.0 [(M-H)']. Example A20 (4.5-Dichloro-2-nitro-phenyl-carbamic add tert-butyl ester The title compound was prepared via the di-Boc compound from commercially available 4,5-dichloro-2-nitroaniline [CAS-No. 6641-64-1] (41.5 g, 200 mmol) and B0C2O (89.7 g, 411 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained by column chromatography (toluene/ethylacetate 19: 1) as a pale brown solid (58.9 g, 96%). MS (ISN) 306.1 [(M-H)-]. Example A21 (4-Chloro-5-ethoxy-2-nitro-phenyl)-carbamic add tert-butyl ester The title compound was prepared via the di-Boc-compound from 4-chloro-5-ethoxy-2-nitro-phenylamine [prepared by stirring commercially available 4,5-dichloro-2-nitro-phenylamine [CAS-No. 6641-64-1], ethanol and KOH in DMSO at 23 °C for 20 days and at 60 °C for 20 h] (7.38 g, 34.7 mmol) and B0C2O (15.61 g, 71.5 mmol), followed by treatment with 2 eq, TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (7.09 g, 66%). MS (ISN) 315 [(M-H)-] and 317 [(M+2-H)-]; mp 45-82 °C Example A22 r2-Nitro-4-trifluoromethoxy-phenyl')-carbamic add tert-butyl ester Reaction of commercially available N-(2-nitro-4-trifluoromethoxy-phenyl)-acetamide CAS-No, [787-57-5] (10.0 g, 37.6 mmol) with Boc-anhydiide (8.68 g, 39.7 mmol) according to the general procedure A (method c) and subsequent reaction with anmionium hydroxide (25%; 11.7 ml, 75.7 mmol) gave after aqueous work up and purification by column chromatography on silica gd (cydohexane/ethyl acetate 4:1) the title compound (12.04 g, 99%) as a brown solid. MS (ISN) 321 [(M-H)-]. Example A23 (5-Cyclopropylmethoxy-2-nitro-4-trifluoromethyl-phenyl)-carbaTm'c add tert-butyi ester The tide compound was prepared via the di-Boc-compound fi:om 5-cydopropyl-methoxy-2-nitrO"4-trifluoromethyl-phenylamine [prepared by stirring commerdally available 5-chloro-2-nitro-4-trifiuoromethyl-phenylamine [CAS-No. 35375-74-7], (hydroxymethyl)cyclopropane and KOH in DMSO at 23 °C for 4 days and at 60 °C for 7 days] (4.49 g, 16.3 mmol) and B0C2O (7.45 g, 34.1 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (4.24 g, 85%). MS (ISN) 375 [(M-H)-]; mp 81 °C. Example A24 [2-Nitro-4-f2,2.2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester Reaction of N-[2-nitro-4-(2,2-trifluoro-ethoxy)-phenyl]-acetamide CAS-No.[97963-71-8] (4.25 g, 15 mmol) with Boc-anhydride (3.50 g, 16 mmol) according to the general procedure A (naetiiod c) and subsequent reaction with ammonium hydroxide (25%; 4.6 ml, 29.8 mmol) gave after aqueous work up and purification by column chromatography on silica gd (cyclohexane/ethyl acetate 4:1) the title compound (3.683 g, 73%) as a ydlow solid. MS (ISN) 335 [(M-H)"3; mp 86-87 °C Example A25 The title compound was prepared via thr di-Boc-compound from 4-chloro-2-nitro-5-(2,2,2-trifluoro-ethox5^)-phenylamin [prepared by stirring commercially available 4,5-dichloro-2-nitro-phenylamine [CAS-No. 6641-64-1], 2,2,2-trifluoro-ethanol and KOH in DMSO at 60 °C for 5 days] (933 g, 34.5 mmol) and B0C2O (15.8 g, 72.4 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (8.80 g, 69%). MS (ISN) 369.0 [(M-H)"] and 371 [(M+2-H)-]; mp 67-69 °C. Example A26 The title compound was prepared via the di-Boc-compound from 5-(2-methoxy-ethoxy)-2-nitro-4-trifluoromethyl-phenylamine [prepared by stirring commercially available 5-chloro-2-nitro-4-trifluoromethyl-phenylamine [CAS-No. 35375-74-7], 2-methoxyethanol and KOH in DMSO at 60 °C for 2 days] (12.3 g, 39 mmol) and B0C2O (20.6 g, 94.5 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as a yellow solid (7.906 g, 53%). MS (ISN) 379 [(M-H)']. Example A27 A suspension of (5-chloro-2-nitro-4-trifluoromethyl-phenyl)-carbandc acid tert-butyl ester (Example Al) (6.8 g, 20 mmol), vinyl boronic add [CAS-No. 4363-34-2] {Bull Soc Chitn. Fn 1966, (8), 2557-64} (4.312 g, 60 mmol) and K2CO3 (8.29 g, 60 mmol) in water(10 mL) and dioxane (50 mL) was purged by Ar-stream at 23 °C for 10 min, then tetrakis(triphenylphosphine) palladium(O) (693 mg, 0.6 namol) was added and the mixture was heated to 100 °C for 20 h, filtered, evaporated and purfied by column chromato-graphy on silica gel (hexane/ethyl acetate 9:1) to yield a light yeUow solid (2.476 g, 37%). MS (ISN) 331 [(M-H)-]. Example A28 (2-Nitro-5-propoxv-4-trifluoromethyl-pbenyl)-carbamic acid tert-butyl ester The title compound was prepared via the di-Boc-compound from 5-(2-metiioxy-ethox7)-2-nitro-4-trifluorometiiyi-phenylamine [prepared by stirring comLmercially available 5-chloro-2-nitro-4-trifluoromethyl-phenylaxnine [CAS-No. 35375-74-7] (12,03 g, 50 mmol), n-propanol (30 mL) and KOH (7,26 g, 110 mmol) in DMSO (100 mL) at 60 °C for 8 days] (4.83 g, 13.3 mmol) and B0C2O (8.38 g, 38.4 mmol), followed by treatment with 2 eq. TFA in CH2CI2 according to the general procedure A (method c). Obtained as an orange solid (6.62 g, 99%). MS (ISN) 363 [(M-H)1; mp 91 °C Example A29 fE/ZVr2-Nitro-5-propenyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester A suspension of (5-diloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example Al) (6.8 g, 20 mmol), (E/Z)-l-prop-l-enyl boronic add [CAS-No. 6336-44-3] {Bull Soc. Chim Fn 1966, (8), 2557-64} (5.1 g, 60 mmol) and K3PO4 (12.74 g, 60 mmol) in water(29 mL) and dioxane (65 mL) was purged by Ar-stream at 23 ®C for 10 min, then tetralds(triphenylphosphine) palladium(O) (693 mg, 0.6 mmol) was added and the mixture was heated to 100 °C for 20 h, filtered, evaporated and purified by column chromato-graphy on silica gd (hexane/ethyl acetate 9:1) to yield a lightt yellow oil (3.946 g, 57%). MS(ISN)345[(M-H)-]. Example A30 (5-Hydroxymethyl-2-nitro-4-trifluoromethvl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (5-methyl-2-mtro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A15) by the following sequence: 1.) A mixture of (5-methyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A15 ) (2.42 g, 7.00 mmol), NBS (1.62 g, 9.10 mmol) and benzoyl peroxide (0.50 g, 1.54 mmol) in CCI4 (50 mL) was refluxed and irradiated with a 500 W sunlamp for 6 h. Cooled to 23 °C, filtered the succinimide off and washed with CCI4. After evaporation of the solvent under vaciumi, the crude bromide (2.63 g, 6.59 mmol), KOAc (2.94 g, 30 mmol) and TBAHSO4 (100 mg, 0.3 mmol) in DCM (50 mL) were stirred at 23 °C for l7 h. 2.) The obtained acetic acid 5-tert-butoxycarbonylamino-4-nitro-2-trifluoromethyl-benzyl ester (822 mg, 2.17 mmol) was stirred in THF (10 mL), MeOH (1 mL) and 1M NaOH (6.52 mL, 6.52 mmol) at 23"°C for 2 L Obtained as yellow oil (493 mg), MS (ISN) 335 [(M-H)-]. Example A31 (5-Cyclopropvi-2-nitrO'4-trifluor6melhyl-'phenyl')-carhaiTiic acidtert-butvi ester A mixture of (2-nitro-4-trifluorometliyl-5-vin]d-phenyl)-carbaimc add tert-butyl ester (Example A27) (1.66 g, 5 mmol), trimethylsulfoxoniiim iodide (2.75 g, 12.5 mmol) and benzjitriethylanmaonium chloride (200 mg, 0.878 mmol) in NaOH 50% (15 ml) and DCM (25 ml) was stirred at 23 °C for 2 days. The mixture was diluted with EtOAc and washed with IN HCl, water and brine, dried over MgSO4. Removal of the solvent invacuum left a dark brown oil, which was purified by silica gel column chromatography to give the title compound a yellow solid (659 mg). Residual starting material was removed as follows: To a solution of the obtained material (659 mg, 1.9 mmol) m EtOAc (11.5 ml) and MeCN (11.5 ml), a solution of RuCU (30 mg, 0.133 mmol) and NaI04 (610 mg, 2-85 mmol) in H2O (3.8 ml) is added under vigurous stirring at 0 °C The mixture is being stirred for further 3 min and then quenched with a sat sol. of Na2S203 (19 ml). The mixture was diluted with EtOAc, the aqueous layer was separated, extracted once with EtOAc. The combined EtOAc layers were washed with brine, dried over MgSO4 and charcoal, filtered over dicalite, evaporated and purified by column chromatography on silica gel (heptane/ethyl acetate 9:1) to yield yellow solid (630 g, 36%). MS (ISN) 345.2 [(M-H)-]; mp 117-119 °C General procedure C: Preparation of 5-N-substituted-(2-nitro-phenyl)-carbamic acid tert-butyl esters (5-Chloro or -fluoro-2-nitro-phenyl)-carbamic add tert-butyl ester was stirred with the desired amine optionally with DMSO, DMF, DMA, NMP or THF and/or DIPEA or EtsN at temperatures from 23 °C to 130 °C imtil tic indicated complete disappearance of the chloride or fluoride. The reaction was cooled to 23 °C poured into ice-water, the precipitate was filtered off, washed with water and dried in vacuum. In cases were the I product did not precipitate, the mixture was extracted with EtOAc, washed with water and brine, dried over Na2SO4. Filtration and removal of the solvent in vacuum left a crude product, which was - if necessary - purified by silica gel column chromatography with hexane/EtOAc to give the pure title compound. Example CI f 5-Dimetfaylainino-2-nitro-4-ltrifluorome1hyl-phenyl)-carbamic acid tert-butyl ester The title compound was prepared from (5-fluoro-2-nitro-4-trifluorometh)d-phenyl)-carbamic acid tert-butyl ester (Example A2) (1.62 g, 5.0 mmol) and dimethylamine (5.6 N in EtOH, 4.47 mL, 25.0 mmol) in DMSO (10 mL) at 23 °C according to the general procedure C and obtained as a yellow solid (1.48 g). MS (ISN) 348 [(M-H)-]; mp 110 °C Example C2 (2-Dimethvlaniino-2'-fluoro-5-nitro-biphenyl-4-vlVcarbamic acid tert-butyl ester The title compound was prepared from (2-chloro-2'-£luoro-5-nitro-biphenyl-4-yl)-carbamic add tert-butyl ester (Example Dl) (9.568 g, ca. 26 mmol) and Me2NH (60% in H20,12 mL) in DMSO (87 mL) at 23 °Caccording to the general procedure C Obtained as a yellow solid (4.54 g). MS (ISP) 376.3 [(M+H)+]. Example C3 [5-(CycIopropvl-methyl-aminoV2-nitro-4-trifluoromethvl-phenyn-carbamic add tert-butvi ester The title compound was prepared from (5-diloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example Al) (3-40 g, 10 mmol) and cydopropyl-methyl-amine hydrochloride (3.22g, 30 mmol) and EtsN (6.97 mL, 50 mmol) in DMSO (50 mL) at 23°C according to the general procedure C. Obtained as a yellow solid (3.74 g). MS (ISP) 374.2 [(M+H)+]. Example C4 (4-Chloro-5-isobutylamino-2-nitro-phenyl)-carbamic acid tert-butvi ester The title compound was prepared from (455-dichloro-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A20) (3.0 g, SHI mmol) and isobutylamine (3.57 g, 48.8 mmol) in DMSO (20 mL) at 55 °C according to the general procedure C. Obtained as a brown solid (2.26 g, 67%). MS (ISP) 344.2 [(M+H)1. Example C5 (5-(Methyl-propyl-*amino)-2-nitro)-2-nitro-4-trifluoro add tert-butyl ester The title compound was prepared from (5-ciiloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butjd ester (Example Al) (4.00 g, 11.7 mmol), N-methyl-prop)damine (1.89 ml, 17.6 mmol) and trieth^damine (5.73 ml, 41.1 mmol) in DMSO (30 mL) at RT according to the general procedure C. Obtained as a yellow solid (4.04 g, 91%). MS (ISP) 378.3 [(M+H)+]. Example C6 (5-Isobutylamino-2-nitro-4-trifluoromethyl-phenyl)-carbaimc acid tert-butyl ester The title compound was prepared from (5-chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example Al) (5.00 g, 14.7 romol), isobutyl-amine (7.36 mL, 73.4 mmol) in DMSO (35 mL) at RT according to the general procedure C. Obtained as a yellow solid (5.39 g, 97%). MS (ISP) 376.3 [(M-H)-]. Example C7 f2-Nitro-5-pyrrolidin-l-yl-4-trifluoromethyl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (5-chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example Al) (6.81 g, 20 mmol), pyrrolidine (8.27 mL, 100 nomol) in DMSO (70 mL) at RT according to the general procedure C Obtained as a yellow solid (7.35 g, 98%). MS (ISN) 374 [(M-H)']; mp 138-141 °C. E?cample C8 (5-Morpholin-4-yl-2-nitro-4-trifluoromethyl-phenyl)-carbamic acidtert-butyl ester The title compound was prepared from (5-chloro-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example Al) (1.62 g, 5 mmol), morpholine (2.18 mL, 25 mmol) in DMSO (10 mL) at RT according to the general procedure C. Obtained as a yellow solid (1.83 g, 94%). MS (ISN) 390 [(M-H)1; mp 75 °C Example C9 The title compotind was prepared from (5-chloro-2-mtro-4-1xifluorometh7i-plienyl)-carbamic acid tert-butyl ester (Example Al) (4.00 g, 11.7 mmol), N-isobutyl-methyl-amine (1.54 g, 17,6 mmol) and triethylamine (5.73 ml, 41,1 mmol) in DMSO (30 mL) at RT according to the general procedure C Obtained as a yellow solid (4.18 g, 91%). MS (ISP) 390.3 [(M-H)"]. Example CIO The title compound was prepared from (5-chloro-2-nitro-4-trifluoromethyl-phenyi)-carbamic acid tert-butyl ester (Example Al) (4.00 g, 11.7 mmol), N-isopropyl-methyl-amine (3.67 ml, 352 mmol) and triethylamine (5.73 ml, 41.1 mmol) in DMSO (30 mL) at 50 °C according to the general procedure C. Obtained as a yellow solid (3.27 g, 74%). MS (ISP) 376.3 [(M-H)"]. Example CI 1 The title compound was prepared from (4,5-dichloro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A20) (5.0 g, 16.3 mmol) and N-isobutyl-methyiamine (7.09 g, 81.4 mmol) in DMSO (50 mL) at RT according to the general procedure C. Obtained as a brown oil (5.79 g, 99%). MS (ISP) 358.2 [(M+H)+]. Example C12 The title compound was prepared from (4,5-dichloro-2-nitro-phenyl)-carbamic add tert-'butyl ester (Example A20) (5.0 g, 16.3 mmol) and N-isopropyl-methylamine (5.95 g, 81.4 mmol) in DMSO (50 mL) at 75 °C according to the general procedure C. Obtained as a yellow solid (4.07 g, 73%). MS (ISP) 344.3 [(M+H)+]. General procedure D Preparation of (4-aryi-2-nitro-phenyl-carhamic acid tert-butyl esters bv direct Suzuki-coupling of r4-iocio-2-nitro-phenyl-carbainic acid tert-butyl esters with arylboronic acids A mixture of the (4-iodo-2-nitro-phen)d)-carbamic acid tert-butji ester (3.0 mmol), the arylboronic acid (4.5 mmol) and PdCl2(PPh3)2 (2 mol%) was refluxed in 1,4-dioxane (25 mL) and 2M Na2C03-solution (7.5 mL) [or alternatively with IM NaHCOs-solution (7.5 mL), lia (6.0 mmol) and (Ph3P)4Pci (3 mol%) in DME (30 mL); also possible with EtsN (9.0 mmol), Pd(OAc)2 (3 mol%), PPhs (6 mol%) in DMF (10 mL) at 100 °C] until tic indicated complete conversion of the iodide. The mixture was transferred into a sq)arating fimnd, H2O (25 mL) was added and the product was extracted with ether or EtOAc (3 X 30 mL), The combined organic layers were washed with brine (50 mL) and dried over Na2SO4- Removal of the solvent left a brown residue, which was purified by silica gd column chromatography with cydohexane/ether or cydohexane/EtOAc to give the title compound. Example Dl f 2-Chloro-2'-fluoro-5-nitro-biphenyl-4-yl-carbamic add tert-butyl ester The title compound was prepared from (5-chloro-4-iodo-2-nitro-phenyl)-carbamic add tert-butyl ester [CAS-No. 335349-60-5] (30 g, 75.3 mmol) and 2-fluorophenylboronic add (13.82 g, 98.8 mmol) according to the general procedure D. Obtained as a yellow gum (1.39 g). MS (ISN) 365.0 [(M-H)-]. General procedure E Preparation of f4-aryi-2-nitro-phenyl)-carbamic add tert-butyl esters by Suzuki-coupling of ( 4-iodo-2-nitro-phenyl-carbamic add tert-butyl esters with bisf pinacolato)diboron and subsequent reaction with aryl halides A mixture of the (4-iodo-2-nitro-phenyl)-carbamic add tert-butyl ester (2.0 mmol), bis(pinacolato)diboron (2.2 namol), KOAc (6.0 mmol) and PdCl2(PPh3)2 (3 mol%) in 1,4-dioxane (25 mL) was stirred at 100 °C until tic indicated complete conversion of the iodide [cf. Tetr. Lett. 1997,38,3841-3844]. After addition of the aryl halide (4.0 mmol), PdCl2(PPh3)2 (3 mol%) and 2M Na2C03-solution (7.5 mL) the mixture was stirred at 100 °C until tic indicated complete conversion of the intermediate boronic ester. The mixture was transferred into a separating funnel, H2O (30 mL) was added and the product was extracted with ether or EtOAc (3 x 50 mL). The combined organic layers were washed with brine (100 mL) and dried over Na2SO4- Removal of the solvent left a brown residue, which was purified by silica gel column chromatography with cydohexane/ether or cydohexane/EtOAc to give the tide compound. General procedure F Preparation of 2-nitro-4-pvrrol-l-vl-phenviamines by condensation of 2-nitro-l,4-phenylenediamine with 2,5-dimethoxytetrahydrofijran [cf. J. Heterocycl Chem 1988,25,1003-1005] A mixture of the 2-nitro-l,4-phenylenediamiae (25 mmol) and 2,5-dimethoxytetra-hydrofuran (26 - 32.5 mmol) in HOAc (150 mL) was stirred at 60-120 °C until tic indicated complete conversion of the phenylenediamine. After cooling to 23 °C, the mixture was poured into brine (500 mL) and extracted with EtOAc (3 x 200 mL). The combined organic layers were washed with brine (300 mL) and dried over MgSO4. Removal of the solvent left a brown residue, which was purified by silica gd column chromatography with cydohexane/EtOAc to give the tide compound. Example Fl 2-Nitro-4-pyrrol-1 -yl-phenylamine The tide compound was prepared from 2-nitro-l,4-phenylenediamine [CAS-No. 5307-14-2] (20 g, 131 mmol) and 2,5-dunethoxytetrahydrofuran (18.3 mL, 135 mmol) in HOAc (37 mL) at 95 °C for 3 h according to the general procedure F. Obtained as a red solid (13.5 g). MS (EI) 203 (M+). General procedure G: Preparation of 2.5-dimethoxydihydrofurans bromination of fiirans in MeOH [c£ Tetrahedron 1971,27,1973-1996] To a solution of the furan (177.5 mmol) in a mixture of anhydrous ether (54 mL) and abs. MeOH (79 mL) kept at -35 °C bromine (10.0 mL, 195 mmol) in MeOH (105 mL) was added gradually with stirring. The reaction mixture was stirred for 30 min, saturated with gaseous NH3 to pH 8, and allowed to warm up to 23 °C Poured into ice-water. extracted vnih ether (3 x 400 mL), washed with brine, dried over Na2SO4. Evaporation of the sohrent left a yellow liquid, which was purified by vacuum distillation to give the title compound. General procedure H Preparation of (4"aIkvnvl-2-nitro-phenyl)-carbamic add tert-butyl esters bv Snnngashira-coupling of ('4-iodo-2-nitro-phenyl-carbamic add tert-butyl esters with acetvlenic compounds (also Sonogashira-coupling of (4-ethynyl-2-nitro-phenyl)-carbamic add tert-butjd esters with aryi halides) A mixture of the halide (3,0-4.5 mmol), acetylenic compound (3.0-4.5 mmol), Et3N (13.5 mmol), PdCl2(PPh3)2 (5 mol%) and PPh3 (2,5 mol%) in THF (12 mL) [with very insoluble material DMF (up to 12 mL) could be added] was stirred for 20 min at 23 °C while being purged with Argon. Cul (1.2 mol %) was added and stirring was continued at 60 °C under Argon atmosphere until tic indicated complete conversion of the minor component [c£ /, Org. Chem. 1998,63,8551]. The mixture was transferred into a separating funnel, 5% dtric add (50 mL) was added and the product was extracted with EtOAc (2 X 100 mL). The combined organic layers were washed wih sat NaHCOj-solution (50 mL) and brine (50 mL), followed by drying over MgSO4. Removal of the solvent left a yellow residue, which was purified by silica gd column chromatography with hexane/EtOAc and/or triturated with hexane or aqueous EtOH to give the title compound. General procedure T Preparation of the (2-amino-phenyl)-carbamic add tert-butyl esters by reduction of (2-nitro-phenyP-carbamic add tert-butyl esters Method a: Catalvtic hydrogenation A mixture of the nitro compound (1.0 mmol) in MeOH or EtOH and THF (1:1 ca- 20 mL) [or solely EtOAc for aromatic chlorides] and 10% Palladium on carbon (20 mg), Raney-Ni (20 mg) or 5% Platinum on carbon was stirred vigorously at 23 °C xmder hydrogen atmosphere until tic indicated complete conversion. The catalyst was filtered ' off, washed thoroughly with MeOH or EtOH and THF (1:1) [or EtOAc], the solvent was removed in vacuum to give the title compound, which was generally pure enough for further transformations, but could be crystallized from hot hexane or cydohexane if necessary. Method b: Reduction with SnCl2*2H20 A mixture of the nitre compound (1.0 mmol) and SnCl2*2H20 (5.0 mmol) was either stirred in EtOH (30 mL) at 70-80 °C or alternatively in pyridine (3 mL) and DMF (12 mL) at 23 °C under Argon atmosphere until tic indicated complete conversion [cf. Tetr. Lett. 1984,25,839], The reaction nMXture was brought to pH 8 by addition of sat NaHCOa-solution and extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with brine and dried over Na2SO4. Removal of the solvent left a yellow solid, which - if necessary - can be purified by silica gd column chromatography. Method c: Reduction with Zn and NKLCl To a mixture of the nitro compound (1.0 mmol) in EtOH/THF/sat NH4Cl-solution (1:1:1,30 mL) was added Zinc dust (3.0 mmol) and the mixture was stirred at 70 °C under Argon atmosphere until tic indicated complete conversion. Aqueous workup as described in method b. Example Tl (2-Amino-5-dimethylamino-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (5-dimethylamino-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example CI) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as an amorphous yellow substance (1.34 g). MS(ISP)320[(M+H)1. Example T2 (2-Amino-4-fluoro-phenyl-carbamic add tert-butyl ester The title compound was prepared from (4-fluoro-2-nitro-phenyl)-carbamic add tert-butyl ester (Example A3) (32.54 g, 127 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a Ught orange solid (25.03 g)- MS (ISP) 227 [(M+H)+; mp 119-121 °C. Example T3 (2-AminO"4-lTifluoromelhvl-phenyl)-carbainic add tert-butyl ester The title compound was prepared from (2-nitro-4-trifluoromethyl-plien)d)-carbamic acid tert-butyl ester (Example A4) (30.0 g, 98 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a Kght yellow solid (26.5 g). MS (ISP) 277.2 [(M+H)+]; mp 133-135 °C. Example T4 (2-Amino-4-chloro-phenyl-carbamic acid tert-butyl ester The tide compound was prepared from (4-chloro-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example A5) (22.12 g, 85 mmol) by reduction with SnQ2*2H20 according to the general procedure J (method b). Obtained as a red solid (13.93 g). MS (EI) 242 (M+) and 244 [(M+2)']; mp 127-128 °C. Example T5 f 2-Amino-4-chloro-5-fluoro-phenyl)-carhamic acid tert-butyl ester The title compound was prepared from (4-chloro-5-fluoro-2-nitro-phenyl)-carbamic add tert-butyl ester (Example A6) (16.48 g, 56.7 mmol) by hydrogenation with 5 % Pt/C according to the general procedure J (method a). Obtained as a brown solid (14.78 g). MS (ISP) 261.2 [(M+H)+] and263 [(M+2+H)+]; mp 85-87 °C. Example Jfi f2-Amino-5-(2.2,2-trifluoro-ethoxyV4-trifluoromethvl-phenyl]-carbamic add tert-butyl ester The title compound was prepared from [2-nitro-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example A) by hydrogenation with 5 % Pt/C according to the general procedure J (method a). Obtained as a yellow solid (17.374 g). MS(ISP)375[(M+H)+]. Example T7 (2-Amino-5'methoxy>4"txifluorometM-ph€nvlVcarbaim add tert-butyl ester The title compound was prepared from (5-methoxy-2-nitro-4-trifluorome1ir5d-pheriyl)-carbamic add tert-butyl ester (Example A8) (5.79 g, 17,2 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a yellow solid (5.36 g). MS (ISP) 307 [(M+H)+]; mp 125 °C. E3cample T8 (2-Armno-5"ethoxy"4-trifluoromethyl-phenyl)-carbainic add tert-butyl ester The title compound was prepared from (5-ethoxy-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A9) (532 g, 15.8 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a yellow solid (3.84 g). MS (ISP) 321 [(M+H)+]; mp 53 X. Example T9 (2-Amino-4*methoxy"phenyl-carbamic add tert-butyl ester The title compound was prepared from (4-methoxy-2-nitro-phenyl)-carbamic add tert-butyl ester (Example AlO) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a white solid (19.377 g). MS (ISP) 239.3 [(M+H)+]; mp 114-115 X. Example TIO (5-Amino-2-dimethvlainino-2'-fluoro-biphenyl-4-yl-carbamic add tert-butyl ester The title compound was prepared from (2-dimethylamino-2*-fluoro-5-nitro-biphenyl-4-yl)-carbamic add tert-butyl ester (Example C2) (4.54 g, 12.1 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a light brown solid (3.324 g). MS (ISP) 346.4 [(M+H)^]; mp 118-123 °C. Example Til f 2-Aiiiino-4"pvrrol-l-vl-phen^Vcarbamic add tert-butyl ester The title compound was prepared from (2-nitro-4-pyrrol-l-")d-plienyl)-carbamic add tert,-butyl ester (Example All) by hydrogenation with 5 % Pd/C according to the general procedure J (method a). Obtained as a white solid (9,06 g). MS(ISP)274[(M+H)+]. Example T12 (2-Amino-5-methoxy-phenyl-carbamic add tert-butyl ester The title compound was prepared from (5-methoxy-2-nitro-phenyl)-carbanuc add tert-butyl ester (Example A12) (12.234 g, 45.6 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a purple solid (7.185 g). MS (EI) 238.1 (M+); mp 98-99 X. Example T13 ;2-Amino-5-(2.2.2-trifluoro-ethoxy)-phenyl-carbamic add tert-butyl ester The title compound was prepared from [2-nitro-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester (Example A13) by hydrogenation with 5 % Pt/C according to the general procedure J (method a). Obtained as a Kght brown solid (13.157 g). MS(ISP)307[(M+H)']. Example T14 (2-Amino-5-ethoxy-phenyl-carbamic add tert-butyl ester The title compound was prepared from (5-ethoxy-2-nitro-phenyl)-carbamic add tert-butyl ester (Example A14) (8.65 g, 30.6 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a purple solid (6.45 g), MS (ISP) 253 [(M+H)+']; mp 60-95 °C. Example T15 The title compound was prepared from [5-(cydopropyl-metbjd-amino)-2-mtro-4-trifluoromethyl-phenyi]-carbamic acidtert-butjd ester (Example C3) (3.74 g, 9.96 mmol) by reduction with SnQ2»2H20 according to the general procedure J (method b). Obtained as an orange semisolid (2.00 g). MS (ISP) 346.4 [(M+H)""]. Example T16 The title compoxmd was prepared from (4-chloro-5-isobutylamino-2-nitro-phenyl)'-carbamic acid tert-butyl ester (Example C4) (1.93 g, 5.61 mmol) by reduction with SnClf 2H2O according to the general procedure J (method b). Obtained as a brown soUd (1.30 g, 74%). MS (ISP) 314.3 [(M+H)""]. Example T17 The title compound was prepared from [5-(methyl-propyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example C5) (3.78 g, 10.0 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a red oil (3.40 g, 98%). MS (ISP) 248.4 [(M+H)1. Example 118 The title compound was prepared from [5-(isobutyl-amino)-2-nitro-4-trifluoromethyl-phenyl]-carbamic addtert-butyl ester (Example C6) (5.28 g, 13.99 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a pale yellow solid (3.69 g, 76%). MS (ISP) 348.5 [(M+Hr];mp UrC. Example T19 The title compound was prepared from (5-cbIoro-2-nitro-4-triflluoromethyl-phenyl)-carbamic add tert-butyl ester (Example Al) (7.00 g, 20.5 mmol) by reduction -with SnCl2'2H20 according to the general procedure J (method b). Obtained as a yellow solid (3.13 g, 49%). MS (ISP) 3093 [(M-H)1;mp 170X. Example T20 The title compound was prepared from (5-methyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example A15) (3.40 g, 10.6 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as light gray solid (3.0 g, 97%). MS (ISP) 291.2 [(M+H)']; mp 174 ^C. Example 121 (2-Amino-5-chloro-4-methyl-phenyl)-carbamic add tert-butyi ester was prepared from (5-chloro-4-methyl-2-nitro-phenyl)-carbamic add tert-butyl ester (Example A16) (11.9 g, 41.4 mmol) by reduction with SnCl2H2O according to the general procedure J (method b). Obtained as a yellow solid (9.25 g, 87%). MS (ISP) 257.1 [(M+H)+]; mp 147 °C Example T22 The title compound was prepared from (4-chloro-5-methyl-2-nitro-phenyl)-cafbandc add tert-butyl ester (Example A17) (4.45 g, 15.5 imnol) by reduction with SnCl2'2H20 according to the general procedure I (method b). Obtained as a yellow solid (3,90 g, 98%). MS (ISP) 257.2 [(M+H)+]; mp 171 °C. Example T23 (2-Amino-4-chloro-5-ethoxy-phenyl)-carbamic add tert-butyl ester Prepared from (4-metii)d-2-mtro-5-1xifluoromethyl-piienyi)-carbamic acid tert-butyl ester.(Example A18) (4.68 g, 14.6 mmol) by hydrogenation "with 10% Pd/C according to the general procedure J (method a). Obtained as a white solid (3.68 g, 87%). MS (ISP) 291.3 [(M+H)+]; mp 144 °C. Example T24 (2-Amino-4-chloro-5-ethoxy-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (4-chloro-2-nitro-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A19) (3.37 g, 0.99 mmol) by reduction with SnCl2'2H2O according to the general procedure J (method b). Obtained as an orange solid (2.55 g, 83%). MS (ISP) 309.2 [(M-H)-]; mp 137 °C Example T25 (2-Amino-4-chloro-5-ethoxy-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (4-diloro-5-ethox7-2-nitro-phenyl)-carbamic add tert-butyl ester (Example A21) (7.04 g, 22.2 mmol) by hydrogenation with 5 % Pt/C according to the general procedure J (method a). Obtained as a hght yellow solid (6.32 g, 99%). MS (ISN) 285 [(M-H)-] and287 [(M+2-H)"];mp 148 °C Example T26 f 2-Amino-4-trifluoromethoxy-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-nitro-4-trifluoromethoxy-phenyl)-carbamic add tert-butyl ester (Example A22) (10,38 g, 32.2 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a li^t brown solid (8.76 g, 93%). MS (ISN) 293 [(M-H)-]; mp 90 °C. Example T27 (2-Amino-5-cyclopropylmethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl The title compound was prepared from (2-nitro-5-pyrroKdin-l-yl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example C7) (7,45 g, 19.75 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a light orange solid (6.75 g, 99%). MS (ISP) 346 [(M+H)+]; mp 101-103°C Example T28 (2-Amino-5-cyclopropylmethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl The title compound was prepared from (5-morpholin-4-yl-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example C8) (1.83 g, 4.68 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as an amorphous red substance (L72 g, 102%). MS(ISP)362[(M+H)']. Example T29 (2-Amino-5-cyclopropylmethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (5-cydopropylmethoxy-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A23) (5,18 g, 13.8 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a light brown solid (3.80 g, 80%). MS (ISP) 347 [(M+H)+]; mp 127°C Example T30 (2-Amino-4-(2.2,2-trifluoro-ethoxy)-phenyll-carbamic add tert-butyl ester The titie compound was prepared from [2-nitro-4-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester (Example A24) (3.65 g, 11 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a light brown solid (3.16 g, 94%), MS (ISP) 307 [(M-hH)+]; mp 127-128 °C Example T31 [2-Amino-4-chloro-5-(2,2,2,-.2-trifluoromethyl-phenyl|-carbarnic add tert-butyl ester The title compound was prepared from ([4-chloro-2-nitro-5-(2,2>2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester (Example A25) (8.70 g, 23.5 mmol) by hydrogenation with 5 % Pt/C according to the general procedure J (method a). Obtained as a yellow solid (7.94 g, 99%). MS (ISP) 341.2 [(M+H)1 and 343 [(M+2+H)+]; mp 91-93 '°C. Example T32 (2-Amino-5-(2-methoxy-ethoxy)-4-trifluoromethyl-phenyll-carbanuc add tert-butyl ester The title compound was prepared from [5-(2-methoxy-ethoxy)-2-nitro-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example A26) (7.90 g, 20.8 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a yellow solid (7.00 g, 96%). MS (ISP) 351 [(M+H)+]; mp 96-100 °C. Example T33 (2-Amino-5-ethyl-4-trifluoromethvl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-nitro-4-trifluoromethyl-5-vinyl-phenyl)-carbamic add tert-butyl ester (Example A27) (1.20 g, 3.6 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a white solid (1.289 g, 100%). MS (EI) 304 (M+); mp 133-139 °C. Example T34 (2-Amino-4-trifluoromethyl-5-vinyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-nitro-4-trifluoromethyl-5-vinyl-phenyl)-carbamic add tert-butyl ester (Example A27) (1.01 g, 3.0 mmol) by reduction with SnCl2'2H2O according to the general procedure J (method b). Obtained as an orange solid (669 mg, 74%). MS(ISP)303[(M+H)+]. Jtacampie i^ty (7-ATTiinn-5"propoxy-4-trifluoromet3iyi-phenyl"CarhaTTiic add tert-butyl ester The title compound was prepared from (2-nitro-5-propoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A28) (6.46 g, 17.7 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (mediod a). Obtained as a white solid (0.93 g, 16%). MS (ISP) 335 [(M+H)+]; mp 120 °C Example T36 (2-Aminn-5-propyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (E/Z)-(2-nitro-5-propenyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Bcample A29) (3,0 g, 8.7 mmol) by hydrogenation with 5 % Pt/C according to the general procedure J (method a). Obtained as a yellow solid (2.984 g, 100%). MS(ISN)317[(M-H)-]. Example T37 f 2-Ainino-5-fluoro-4-trifluoromethvl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (5-£luoro-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A2) (3.34 g, 10.3 mmol) by hydrogenation with 10 % Pd/C according to the general procedure J (method a). Obtained as a yellow solid (2.93 g, 97%). MS (ISP) 295.2 [(M+H)+]; mp 107-109 °C. Example T38 (2-Amino-5-(tetrahvdro-pyran-2-yloxvmethylV4-trifluoromethyl-phenyl1-carbaim add tert-butyl ester The title compound was prepared from [2-nitro-5-(tetrahydro-pyran-2-yloxymethyl)-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester [prepared from (5-hydrox7methyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A30) (476mg, 1.42 mmol) by treatment with 3,4-dihydro-2H-pyran (0.19 mL, 2.12 mmol) and p-TsOH (5 mg, 0,03 mmol) in DCM at 0°C stirring at 0 °C for 15 min and at 23 °C for 18 k] (0.58 g, 1.38 mmol) reduction with SnCl2'2H2O according to the general procedure J (method b). Obtained as an aniiorphous yellow substance (414 mg, 77%). MS (ISP) 391 [(M+H)+]. Example T39 (2-Amino-5"Cydopropvi-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (5-cydopropyl-2-nitro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example A31) (460 mg, 1.33 mmol) by reduction with SnCl2"2H2O according to the general procedure J (method b). Obtained as an orange solid (300 mg, 71%). MS (ISP) 317.1 [(M+H)+]; mp 134-137 °C, Example T40 (2-Amino-5-(isobutyl-methyl-aniino)-4-trifluoromethyl-phenyll-carbaEQic add tert-butyl ester The title compound was prepared from [5-(isobutyl-methyl-amino)-2-mtro-4-trifluoromethyl-phenylj-carbamic add tert-butyl ester (Example C9) (3.88 g, 9.91 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a orange oil (2.70 g, 75%). MS (ISP) 362.3 [(M-hH)+]. Example T41 [2-Amino-5-fisopropyl-metfavl-aminoV4-trifluoromethyl-phenyl1-carbamic add tert-butyl ester The title compound was prepared from [5-(isopropyl-methyl-amino)-2-nitro-4-trifluoromethyl-phenylj-carbamic add tert-butyl ester (Example CIO) (2.98 g, 7.90 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a orange oil (2.42 g, 88%). MS (ISP) 348.5 [(M+H)1. Example T42 [ 2-Amino-4-diloro-5-(isopropyl-methyl-amino)-1-phenyl-carbamic add tert-butyl ester The title compoiind was prepared from [4-chloro-5-(isobutyl-methyl-amino)-2-nitro-phenyl]-carbamic add tert-butyl ester (Example C24) (5.55 g, 15.5 mmol) by reduction with SnQ2'2H2O according to the general procedure J (method b). Obtained as a pale brown solid (3.98 g, 78%). MS (ISP) 328.3 [(M+Hf]. Example T43 [ 2-Amino-4-diloro-5-(isopropyl-methyl-amino)-phenyl-carbamic add tert-butyl ester The title compound was prepared from [4-diloro-5-(isopropyi-methyl-amino)-2-nitro-phenyl]-carbamic add tert-butyl ester (Example C12) (4.07 g, 11.8 mmol) by reduction with SnQ2 2H2O according to the general procedure J (method b). Obtained as a pale brown solid (3.08 g, 83%). MS (ISP) 314.3 [(M+H)+]; mp 116 °C. The following methods relate to the preparation of the ethyl or tert-butyl 3-aryl-3-oxo-propionates (general formula IVa), which serve as building blod:s in the syndesis of the target compounds (Synthetic Scheme G). General procedure K Method aV Preparation of ethyl or tert-butyl 3-aryl-3-oxO"propionates The ethyl or tert-butyl 3-aryl-3-oxo-propionates were prepared from the aryl add chlorides and ethyl or tert-butyl malonate potassium salt [CAS-no. 6148-64-7 and 75486-33-8] with EtsN and MgCla in CH3CN at 0 X to 23 °C according to Synthesis 1993,290. If the free aryl carboxylic add was employed in this reaction, it was activated by treatment with ethyl cbloroformate and EtsN in THF/CH3CN at 0 °C prior to reaction with the malonate salt Method b): Preparation of tert-butyl 3-arvl-3-oxo-propionates The tert-butyl 3-aryl-3-oxo-propionates were alternatively prepared from the methyl or ethyl aryl esters by treatment with lithium tert-butyl acetate [prepared by treatment of tert-butyl acetate with lithium diisopropylamide in THF at -78 °C] in the presence of Hthium tert-butoxide according to Synthesis 1985,45. If the product contained residual starting material after workup, tiius could be removed by sdective saponification with liOH in THF/MeOH/HsO at 23 °C Method c): Preparation of 3-aryl-3-oxo-propionic adds The 3-aryl-3-oxo-propionic adds were prepared from the aryl add chlorides and bis(trimethylsil)d)malonate with EtsN and LiBr in CH3CN at 0 °C according to Synth. Commun. 1985, J5,1039 (method cl) or with n-BuIi in ether at -60 °C to 0 °C according to Synthesis 1979,787 (method c2). Method d): Preparation of ethyl or tert-butyl 3-ar)d-3-oxo-propionates The ethyl or tert-butyl 3-aryl-3-oxo-propionates were prepared from the aryi nitriles and ethyl or tert-butyl bromoacetate [CAS-No. 105-36-2 and 5292-43-3] with activated Zinc dust in THF at reflux, followed by treatment of the obtained enamino ester with 10% Ha in THF at 23 °C according to /, Org.Chem. 1983,45,3835. Example Kl 3-Oxo-3-(3-pyridin-3-A4-phenylVpropionic addtert-butyl ester The tide compound was prepared from 3-pyridm-3-yl-benzoic add methyl ester [CAS-No. 79601-27-7] (1.00 g, 4.69 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as an orange oil (673 mg). MS (ISP) 298.4 [(M+H)+]. Example K2 3-Oxo-3-f 3-pyridin-4-yl-phenylVpropionic add tert-butyl ester The title compound was prepared from 3-pyridin-4-yl-benzoic add methyl ester [CAS-No. 126179-78-0] (3.60 g, 16.88 namol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (3.88 g). MS (ISN) 296.3 [(M-H)-]. Example K3 3-Oxo-3-f3-pvridin-2-vl-phenyl-propionic acid tert-butyl ester The title compond was prepared from 3-pyridin-2-yl-benzoic add methyl ester [CAS-No. 98061-20-2] (9.42 g, 44.18 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (8.35 g). Example K6 3-f3-(6-Methyl-pyrida2in-3-yl)-phenyl1-3-oxo-propiQmc add tert-butyl ester The title compound was prepared from 3-(6-methyl-pyridazin-3-yl)-benzoic acid methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboronic add (2.24 g, 13,5 mmol) and 3-diloro-6-methylpyridazine (1.79 g, 13.5 mmol) in acetonitrile {67 mL) and 0.4M NaaCOs-solution (67 mL) was degassed and Pd(Ph3P)4 (0.78 g, 5 mol%) was added The reaction mixture was refluxed for 16 h, evaporated to dryness (c£ synlett 2000 829). The residue was suspended in MeOH (200 mL) and SOCI2 (4.9 mL, 67.5 mmol) was added dropwise at 23 °C and the reaction mixture was refluxed for 16 h. Evaporated to dryness, taken up in EtOAc, washed with sat NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown oil, which was purified by silica gd column chromatography with cydohexane/EtOAc] (2.57 g, 11.26 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a light ydlow solid (2,68 g). MS (ISP) 313 [(M+H)+]; mp 68 °C. Example K7 3-r3-f6-Methoxy-pyridazin-3-yl)-phenyn'3-oxo-propionic add tert-butyl ester The tide compound was prepared from 3-(6-methoxy-pyridazin-3-yl)-benzoic add methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboronic add (7.11 g, 42.8 mmol) and 3-chloro-6-methoxy-pyridazine [CAS-No. 1722-10-7] (6.19 g, 42.8 mmol) in acetonitrile (212 mL) and 0.4M Na2C03-solution (212 mL) was degassed and Pd(Ph3P)4 (2.47 g, 5 mol%) was added The reaction mixture was refluxed for 16 h, evaporated to dryness (c£ Synlett 2000,829). The residue was suspended in MeOH (630 mL) and SOCI2 (15.5 mL, 214.1 mmol) was added dropwise at 23 °C and the reaction mixture was refluxed for 4 h. Evaporated to dryness, taken up in EtOAc, washed with sat NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown oil, which was purified by silica gd column chromatography with cydohexane/EtOAc] (5.41 g, 22.15 mmol) by treatment with hthium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (6.39 g). MS(ISP)329[(M-hH)+]. Example K8 3-[3-(2.6-Dimethyl-pyridin-3yl)-phenyl1-3-oxo-propiomc acid tert-buthyl ester The title compound was obtained from 3-(2,6-dimethyl-pyridin-3-yi)-benzomtrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (4.74 g, 32,25 mmol), 3-bromo-2,6-dimethylpyridine[CAS-No. 3430-31-7] (5.00 g, 26.87 mmol) and K3PO4 (8.56 g, 3578 mmol) in dioxane (126 mL) was degassed and Pd(Ph3P)4 (1.53 g, 1.37 mmol) was added. The reaction mixture was stirred at 90°C for 18 L Evaporated to dryness, taken up in EtOAc, washed vdih sat. NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, whidbt was purified by silica gel column chromatography with cydohexane/EtOAc] {22 g, 10.6 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as an orange oil (2.61 g). MS (ISP) 326.4 [(M+H)+]. Example K9 3-Oxo-3-(3-pyridazin-4-yl-phenyl)-propionic add tert-butyl ester The tide compound was prepared from 3-pyrida2in-4-yl-ben2oic add methyl ester [prepared by the following sequence: L) An equimolar mixture of glyoxylic add and m-tolyi-acetaldehyde [CAS-No. 72927-80-1] was heated to 135 °C for 17 h. ii.) The obtained crude 5-hydroxy-4-(m-tolyi)-2(5H)-friranone and hydrazine hydrate in BuOH were refluxed for 18 h according to /. Med Chem. 1987,30y 239. iiL) The obtained 5-m-tolyi-2H-pyrida2in-3-one was heated with excess phosphorous oxychloride to 95 °C for 4 h. iv.) The obtained 3-chloro-5-m-tolyl-pyrida2ine was hydrogenated in MeOH and EtOAc over 5% Pd/C in the presence of NaOAc at 23 °C. v.) The obtained 4-m-tolyl-pyrida2ine was oxidized with KMn04 in aqueous HOAc at 100 °C for 4 L vi.) The obtained 3-pyridazin-4-yl-benzoic add was esterified with SOCI2 in MeOH at 60 °C.] by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (554 mg). MS(ISN)297[(M-H)1. Example K10 3-[3-(6-Methyl-pyridin-2-yl)-phenyn-3-oxo-propionic acid tert-butyl ester The title compound was obtained from 3-(6-met3aox7-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cj^nophenylboronic add [CAS-No, 150255-96-2] (6.47g,44mmol),5-bromo-2-methoxypyridine [CAS-No. 13472-85-0] (5.18 mL, 40 mmol) and K3PO4 (12.74 g, 60 mmol) in dioxane (200 mL) was d^assed and Pd(Ph3p)4 (2.31 g, 5 mol%) was added. The reaction mixture was stirred at 90 °C for 4.5 h. Evaporated to dryness, taken up in EtOAc, washed with sat NaHCOa-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gel column dnromatography with cydohexane/EtOAc] (1,95 g, 9.28 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HQ according to general procedure K (method d). Obtained as a brown oil (2.81 g). MS (ISN) 326.2 [(M-H)-]. Example Kll 3-[3-(6-Methyl-pyridin-2-yl)-phenyn-3-oxo-propionic acid tert-butyl ester The tide compound was prepared from 3-(6-methyl-pyridin-2-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (11.10 g, 75.6 mmol), 2-bromo-6-methylpyridine [CAS-No. 5315-25-3] (10.0 g, 58.1 mmol) and K3PO4 (21.22 g, 100 mmol) in dioxane (250 mL) was degassed and Pd(Ph3P)4 (3.36 g, 5 mol%) was added. The reaction mixture was stirred at 90 '°C for 38 h. Evaporated to dryness, taken up in EtOAc, washed with sat. NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gd column chromatography with cydohexane/EtOAc] (6.36 g, 32.7 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HQ according to general procedure K (method d). Obtained as a ydlow oil (7.84 g). MS(ISN)311[(M-H)']. Example K12 3-[3-(6-Methyl-pyridin-2-yl)-phenyn-3-oxo-propionic acid tert-butyl ester The title compound was prepared from 3-(2-methyl-pyridin-4-yl)-b€nzoic add methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboroiiic add (7.13 g, 43.0 mmol) and 4-bromo-2-methylpyridine [Chem. Phann. Bull. 1990,38 (9), 2446 - 2458] (7.40 g, 43.0 mmol) in acetonitrile (215 ml) and 0.4M Na2C03-solution (215 ml) was degassed and Pd(Ph3P)4 (5.0 g, 0.43 mmol) was added The reaction mixture was refluxed for 18 h and evaporated to dryness [Synlett 2000 (6), 829 - 831]. The residue was suspended in MeOH (215 ml), SOCI2 (15-6 ml, 215 namol) was added dropwise at RT and the reaction mixture was refluxed for 4h. Aqueous work-up and further purification by column chromatography as described in example K4] (10.1 g, 44,4 mmol) by treatment with tert-butyl acetate according to general procedure K (method b). Obtained as a light yellow oil (9.50 g, 69 %). MS (ISP) 312.3 [(M+H)+]. Example K13 3-Oxo-3-( 3-pyrazin-2-yl-phenyl)-propionic add tert-butyl ester The tide compound was obtained from 3-(3-pyrimidin-5-yl)-ben2oic add methyl ester [prepared by the following procedure: A mixture of 3-carboxyphen)iboronic add (7.13 g, 43-0 mmol) and commerdally available 5-bromo-pyrimidine (6.84 g, 43.0 mmol) in acetonitrile (215 ml) and 0.4M Na2C03-solution (215 ml) was degassed and Pd(Ph3P)4 (5.0 g, 0.43 mmol) was added. The reaction mixture was refluxed for 4 h and evaporated to dryness [Synlett 2000 (6) 829 - 831]. The residue was suspended in MeOH (215 ml), SOCI2 (15.6 ml, 215 mmol) was added dropwise at RT and the reaction mixture was refluxed for 4h. Aqueous work-up and further purification by column chromatography as described in example K4] (7,63 g, 35.6 mmol) by treatment with tert-butyl acetate according to general procedure K (method b). Obtained as a light yellow oil (6.17 g, 58%). MS (ISP) 299.4 [(M+H)+]. Example K14 3-Oxo-3-( 3-pyrazin-2-yl-phenyl)-propionic add tert-butyl ester The title compound was prepared from 3-(3-pyrazin-2-yl)-benzoic add methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboronic add (7.13 g, 43.0 mmol) and commerdally available 2-chloro-pyra2ine (4.93 g, 43.0 mmol) in acetonitrile (215 ml) and 0.4M NaoCOs-solution (215 ml) was degassed and Pd(Ph3P)4 (5.0 g, 0.43 mmol) was added. The reaction mixture was refluxed for 4 h and evaporated to dryness [Synlett 2000 (6), 829-831]. The residuewas suspended in MeOH (215 ml), SOCI2 (15.6 nal, 215 mmol) was added dropwise at RT and the reaction mixture was refluxed for 5h. Aqueous ivork-iip and further purification by column chromatogr^hy as described in example K4] (6.79 g, 31.7 mmol) by treatment with tert-butyl acetate according to general procedure K (method b). Obtained as an orange oil (4.57 g, 48%). MS (ISP) 299.4 [(M+Hf]. Example K15 3-f 3-(2.6-Dimethvl-pvridin-4-vD-phenvn-3-oxo-propionic acid tert-butyl ester The title compound was prepared from commercially available 3-cyanophenylboronic add [CAS-No.150255-96-2] and 4-bromo-2,6-dimethylpyridine [C/zem. Phamu BulL 1990,38,2446 and /. Org. Chem. 1962,27,1665] according to general procedure K (method d, example K8). Obtained as an orange oiL MS (ISP) 326.4 [(M+H)+]. Example K16 3-[3-(6-Methyl-pyrazin-2-yl-phenyl]-3-oxo-propionic acid tert-butyl ester The title compound was prepared from commercially available 3-cyanophenylboronic add [CAS-No.l50255-96"2] and commerdally available 2-chloro-6-methylpyrazine according to general procedure K (method d; example K8). Obtained as a Hght brown oil. MS (ISP) 313.3 [(M+H)+]. Example K17 3-f3-(2.5-Dimethyl-pvridin-4-yl)-phenyl1-3-oxo-propionic add tert-butyl ester The title compound was prepared from commerdally available 3-cyanophenylboronic add [CAS-No.150255-96-2] and 4-bromo-2,5-dimethyl-pyridine [CAS-No. 17117-23-6] according to general procedure K (method d; example K8), Obtained as a light yeUow oil. MS (ISP) 326.2 [(M+H)+-]. Example Kl 8 3-f3-(23"Dimethyl-pvridin-4-vD-phenyn-3-oxo-propionic add tert-butyl ester The title compound was prepared from commercially available 3-cyanophenylboronic add [CAS-No.150255-96-2] and 4-bromo-2,3-dimethyl-pyridine [CAS-No. 259807-91-5] according to general procedure K (method d; example K8). Obtained as an orange oil. 10% HQ according to general procedure K (method d). Obtained as a light yellow solid {9.65 g, 64%). MS (ISP) 338.3 [(M+H)+]; mp 72 °C. Example K22 3-[3-(6-Isopropyl-pYridiT)-.^-ylVphenyll-3-oxo-propionic add tert-butyl ester The title compound was obtained from 3-(6-isopropyl-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (5.78 g, 39.3 mmol), crude 5-bromo-2-isopropenyl-pyridine{prepared by the following procedure: A solution of dried ZnQa (6.81 g, 50 mmol) in THF (71 mL) was added dropwise to isopropenyl magnesiumbromide-solution 0.5 M (100 mL, 50 nmaol) at -75 °C and the mixture was allowed to warm up to 23 °C. A solution of 2,5-dibromopyridine (9.12 g, 35.5 mmol) and Pd(PPh3)4 (450 mg, 0.39 mmol) in THF (50 mL) was added dropwise at 23 °C and the reaxtion mixture was refluxed for 20 h. Cooled to room temperature, poured into sat NaHCOa-solution, extracted with ether, washed with brine, dried over Na2SO4. Removal of the solvent in vacumn left a brown Uquid (10.98 g).} (ca. 36 mmol), Pd(PPh3)4 (1-24 g, 3 mol%) and K3PO4 (11.38 g, 53.1 mmol) in dioxane (180 mL) was stirred at 90 '°C for 18 h. Cooled to room temperature, diluted with EtOAc, washed with sat. NaHCOs-solution and brine, dried over NaaSO^. Removal of the solvent in vacuum left a brown solid, which was purified by silica gel column chromatography with cydohexane/EtOAc to obtain a yellow solid (4,91 g, 22.3 mmol). This material was hydrogenated with Pd/C 10 % (0.89 g, 0.84 mmol) in EtOAc (210 mL) at 23 °C for 28 h.] (4.71 g, 21.2 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as a light yellow oil (4.95 g, 69%). MS(ISP)340[(M+H)+]. Example K23 3-[3-(6-Ethyl-pyridin-3-vlVphenvn-3-oxo-propiQnic acid tert-butyl ester The title compound was obtained from 3-(6-ethyl-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic acid [CAS-No. 150255-96-2] (2.77 g, 18.8 mmol), 5-bromo-2-ethyl-pyridine [CAS-No, 38749-90-5] (3.24 g, 15.7 mmol), Pd(PPh3)4 (906 mg, 3 mol%) and K3PO4 (4.99 g, 23.5 mmol) in dioxane -(77 mL) was stirred at 90 °C for 18 h. Cooled to room temperature, diluted with EtOAc, washed with sat. NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gel column chromatography with cydohexane/EtOAc to obtain a yellow liquid.] (1.94 g, 9.32 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HQ according to general procedure K (method d). Obtained as a light yellow oil (2.23 g, 74%). MS(ISP)326[(M+Hr]. Example K24 3-[3-(2-Cyano-pvrir1in-4-yl)-phenyl1-3-oxo-propionic add tert-butyl ester The title compound was prepared from 3-(2-cyano-pyridin-4-yl)-benzoic add ethyl ester [prepared by the following sequence: 1.) A mixture of 3-pyTidin-4-yl-benzoic add ethyl ester [CAS-No. 4385-74-4] (4.711 g, 20.7 mmol) and hydrogen peroxide (3.4 mL, 332 mmol) was heated at 70 °C for 8 days {after 4 days ftirther hydrogen peroxide (2.1 mL, 20.7mmol) was added}, then solvent was removed, water (twice 15 mL) was added and volatile compounds were again removed. 2,) The obtained 3-(l-oxy-pyridin-4-yl)-benzoic add ethyl ester (4.763 g, 19.58 mmol), trimethylsilyl cyanide (7.35 mL, 58.7 mmol) and triethylamine (5.46 mL, 39.2 mmol) in acetonitrile (20 mL) was refluxed for 22.5 h. Aftar evaporation of the solvent, the residue was made alkaline with 3N NaaCOj (130 mL) and extracted five times with dichloromethane (120 mL). The combined organic layers were washed with H2O (100 ml) and brine (100 mL), dried over Na2SO4. Removal of the solvent in vacuum left a brown residue, which was pxirified by silica gel column chromatography with cydohexane/EtOAc] (4.51 g, 17.88 mmol) by treatment with Hthium tert-butyl acetate according to general procedure K (method b). Obtained as a ydlow oil (2.53 g). MS (ISN) 321.3 [(M-H)-]. Example K25 3-r3-(6-Amino-pyridin-3-yl)-phenyl1-3-oxo-propiQnic add tert-butyl ester The title compound was obtained from 3-(6-amino-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No, 150255-96-2] (17.0 g, 115.7 mmol), 2-aminO"5-bromo-pyridine [CAS-No. 1072-97-5] (15.64 g, i 90.4 mmol), Pd(PPh3)4 (5.0 g, 5 mol%) and 0.4 M Na2CO3-solution(450 mL) in acetonitrile (450 mL) was stirred at 90 °C for 2 days. Cooled to room temperature, diluted with EtOAc, washed with sat. NaHCOs-solution and brine, dried over Na2SO4-Removal of the solvent in vacuum left a brown solid, whidi was purified by silica gd column chromatography-widi cydohexane/EtOAc to obtain a ydlow solid.] (4.34 g, 22.23 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HQ according to general procediare K (method d). Obtained as a light brown solid (4.41 g, 63%), MS (ISN) 311.1 [(M-H)-]; mp 78-80 °C Example K26 3-f3-(6-Cyano-pYridin-3-vlVphen^]-3-oxo-propionic add tert-butyl ester The title compound was prepared from 3-(6-cyano-pyridin-3-yl)-benzoic add methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboronic add (2.08 g, 12.51 mmol) and 5-bromo-pyridine-2-carbonitrile [CAS-No. 97483-77-7] (2.08 g, 11.37 mmol) in acetonitrile (55 ml) and 0.4M Na2C03-solution (55 ml) was degassed and Pd(Ph3P)4 (657 mg, 0.57 mmol) was added. The reaction mixture was refluxed for 18 h and evaporated to dryness [Sytdett 2000 (6), 829 - 831]. The residue was suspended in MeOH (300 ml), SOa2 (2.61 ml, 36 mmol) was added dropwise at 23 °C and the reaction mixture was stirred at 23 °C for 3 days. Concentrated in vacuum to about 100 mL, diluted with EtOAc, washed with sat NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacutma left a brown residue, which was purified by silica gel column diromatography with cydohexane/EtOAc] (1.38 g, 5.79 mmol) by treatment with lithum tert-butyl acetate according to general procedure K (method b). Obtained as an orange oil (530 mg). MS (ISN) 323.3 [(M-H)-]. Example K27 3-Qxo-3-(3-pyridazin-3-yl-phenyl)-propionic add tert-butyl ester The title compound was prepared from 3-pyridazin-3-yl-benzoic add methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboronic add (6.98 g, 42.06 mmol) and 3-chloropyridazine [CAS-No. 1120-95-2] (4.817 g, 42.06 mmol) in acetonitrile (210 ml) and 0.4M NaaCOs-solution (210 ml) was degassed and Pd(Ph3P)4 (2.43 g, 2.1 mmol) was added. The reaction naixture was refluxed for 15 h and evaporated to dryness [Synlett 2000 (6), 829 - 831]. The residue was suspended in MeOH (500 ml), SOCI2 (15.3 ml, 211 mmol) was added dropwise at 23 °C and the reaction mixture was stirred at reflux for 16 h. Concentrated in vacuum to about 100 mL, diluted with EtOAc, washed with sat. NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown residue, which was purified by siHca gd column chromatography with cydohexane/EtOAc] (7.35 g, 34.32 mmol) by treatment with lithium tert-biityi acetate according to general procedure K (method b). Obtained as a yellow oil (8.306 g, 81%). MS (ISP) 299.3 [(M+Hf]. Example K28 3-r3-f6-Dimethylamino-pyridin"3-vlVphenvn-3-oxo-propiomc acid tert-butyl ester The title compound was obtained from 3-(6-dimeth)dairiino-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (6.994 g, 47.6 mmol), (5-bromo-pyridin-2-yl)-dimethyl-amine [CAS-No. 26163-07-5] (7,326 g, 36.6 mmol), Pd(PPh3)4 (2.116 g, 1.83 mmol) andK3P04 (12.436 g, 58.6 mmol) in dioxane (180 mL) was stirred at 90 °C for 24 h. Cooled to room temperature, diluted with EtOAc, washed widi sat NaHCOa-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gd colxmm chromatography with cydohexane/EtOAc to obtain a ydlow solid.] (1.157 g, 5.2 nrniol) by treatment with tert-butjd bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as a ydlow oU (1.382 g, 78%). MS(ISP)341[(M+H)+"]. Example K29 3-f3-f2-Cyclopropyl-pyridin-3-yl)-phenyl1-3-oxo-propionic add tert-butyl ester The title compound was obtained from 3-(2-cydopropyl-pyridin-3-yi)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (8.82 g, 60 mmol), crude trifluoro-methanesulfonic add 2-cydo-propyl-pyridin-3-yl ester{prepared by the following procedure: A mixture of trifluoro* methanesulfonic add 2-bromo-pyridin-3-yl ester [CAS-No. 157373-97-2] (5.45 g, 17.81 mmol), cydopropylzinc chloride (0.4 M in THF, 60 mL, 24 mmol), Pd(PPh3)4 (200 mg, 1 mol%) in THF (20 mL) was stirred tmder Argon atmosphere at 70 °C for 1.5 h. Cooled to room temperature, poured into sat NaHCOa-solution, extracted with ether, washed with brine, dried over Na2SO4. Removal of the solvent in vacuum left a yellow oil (5.88 ' g).} (ca. 18 mmol), Pd(PPh3)4 (617 mg, 3 mol%) and K2CO3 (4.92 g, 32 mmol) in toluene (90 mL), EtOH (8 mL) and H2O (18 mL) was stirred at 80 °C for 13 L Cooled to room temperature, diluted with EtOAc, washed with sat. NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown soKd, which was purified by silica gd column chromatography with cydohexane/EtOAc] (3.69 g, 16.75 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HQ according to general procedure K (method d). Obtained as a yellow oil (4.32 g, 76%), MS (ISN) 336.1 [(M-H)-]. Example K30 3-r3-(4-Methyl-pyridin-3-yl)-phenyn-3-oxo-propionic add tert-butyl ester The title compound was obtained fi:om 3-(4-methyl-pyridin-3-yl)-benzonitrile [prepared by the foflowing procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (8.82 g, 60 mmol), 3-bromo-4-methylpyridine [CAS-No, 3430-22-6] (8.60 g, 50 mmol), Pd(PPh3)4 (1.73 g, 3 mol%) and 2M KiCOs-solution (50 mL) in toluene (250 mL) and EtOH (22 mL) was stirred at 80 °C for 3 h. Cooled to room temperature, diluted with EtOAc, washed with sat. NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuxmi left a brown solid, which was purified by silica gd column chromatography with cydohexane/EtOAc] (8,90 g, 45.8 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HQ according to general procedure K (method d). Obtained as an orange oil (12.22 g, 86%). MS (ISP) 312.3 [(M-H)1. Example K31 3-r3-f2-ethyl-pyridin-3-yD-phenyl1-3-oxo-propionic add tert-butyl ester The titie compound was obtained from 3-(2-ethyl-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (3.53 g, 24 mmol), crude trifluoro-methanesulfonic add 2-ethyl-pyridin-3-yl ester{prepared by the following procedure: A mixture of trifluoro-medianesulfonic add 2-bromo-pyridin-3-yl ester [CAS-No. 157373-97-2] (6.12 g, 20 mmol), diethylzinc (1.1 M in toluene, 11 mL, 12 mmol), Pd(PPh3)4 (230 mg, 1 mol%) in THF (90 mL) was stirred imder Argon atmosphere at 70 °C for 1 h. Cooled to room temperature, poured into sat NaHCOs-solution, extracted with ether, washed with brine, dried over Na2SO4-Removal of the solvent in vacuum left a ydlow oil (5.10 g).} (ca. 20 mmol), Pd(PPh3)4 (690 mg, 3 mol%) and K2CO3 (5.53 g, 40 mmol) in toluene (100 mL), EtOH (9 mL) and H2O (20 °CnL) was stirred at 80 °C for 4.5 h. Cooled to room temperature, diluted with EtOAc, washed with sat. NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was pxirified by silica gel column diromatography with cydohexane/EtOAc] (3.44 g, 16.5 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as ayellow oil (1.11 g, 21%). MS(ISP)326[(M+Hf]. Example K32 3-[3-(4^6-Dirnethyl-pyridin-3-ylVphenyl1-3-oxo-propionic acid tert*butyl ester The title compound was obtained from 3-(4,6-dimethyl-pyridin-3-yi)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophen3dboronic add [CAS-No. 150255-96-2] (8.82 g, 60 mmol), 5-bromo-2,4-dimethyl-pyridine [CAS-No. 27063-92-9] (9.3 g, 50 mmol), Pd(PPh3)4 (1.73 g, 3 mol%) and 2M KiCOs-solution (50 mL) in dioxane (250 mL) and EtOH (22 mL) was stirred at 80 °C for 3.5 h. Cooled to room temperature, diluted with EtOAc, washed with sat NaHC03-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by siHca gd column chromatography with cydohexane/EtOAc] (8.90 g, 42.7 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as a yellow oil (2.73 g, 20%). MS (EI) 325.1 {W). Example K33 3- f 3-(6-Cycloprop'sd-4-methyl-pyridin-3-vD-phenyn -S-oxo-propionic add tert-butyl ester The title compound was obtained from 3-(6-cyclopropyl-4-methyl-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (5.15 g, 35 mmol), 5-bromo-2-cydopropyl-4-methyl-pyridine {prepared by the following procedure: A mixture of 2>5-dibromo-4-methyl-pyridine [CAS-No. 3430-26-0] (12.55 g, 50 mmol), cydopropylzmc chloride (0.4 M in THE, 156 mL, 62.5 mmol), Pd(PPh3)4 (580 mg, 1 mol%) in THF (55 mL) was stirred under Argon atmosphere at 70 °C for 1 h. Cooled to room temperature, poured into sat. NaHCOs-solution, extracted with ether, washed with brine, dried over Na2SO4- Removal of the solvent in vacuum left a yellow oil (6.24 g).} (6.19 g, 29.2 mmol), Pd(PPh3)4 (1-01 g, 3 mol%) and 2M K2C03-solution (29 mL) in toluene (146 mL) and EtOH (13 mL) was stirred at 80 °C for 3 h. Cooled to room temperature, diluted with EtOAc, washed with sat. NaHCOa-solution and biine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gd column chromatography with cydohexane/EtOAc] (5.11 g, 21.8 mmol) by treatment with tert-butylbromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as an oflf-wfaite solid (1.93 g, 25%). MS (EI) 351 (M+); mp 65-73 °C. Example K34 3-[3-(2-Ethvl-6-metfivl-pyridin-4"yiVphenyl1-3-oxO"propionic add tert-butyl ester The title compound was obtained from 3-(2-ethyl-6-methyl-pyridin-4-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CA.S-No. 150255-96-2] (11.31 g, 76.9 mmol)4-bromo-2-ethyl-6-methyl-pyridine [CAS-No. 155887-27-7] (12.83 g, 64.1 mmol), Pd(PPh3)4 (2.22 g, 3 mol%) and K2CO3 (17.73 g, 128.2 mmol) m toluene (360 mL), EtOH (29 mL) and H2O (72 mL) was stirred at 80 °C for 2 h. Cooled to room temperature, diluted with EtOAc, washed with sat NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gel column chromatography with cydohexane/EtOAc] (12.34 g, 55.5 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as a yellow oil (15,21 g, 81%). MS (EI) 339 (M+). Example K35 3-f3-f6-Ethvl-4-methyl-pyridin-3-yD-phenyl1-3-oxo-propionic acid tert-butyl ester The title compound was obtained from 3-(6-ethyl-4-methyl-pyridin-3-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (3.53 g, 24 mmol), 5-bromo-2-ethyl-4-metibyl-pyridine{preparedby the following procedure: A mixture of 2,5-dibromo-4-methyl-pyridine [CAS-No. 3430-26-0] (5.0 g, 20 mmol), diethylzmc (1.1 M in toluene, 10.9 mL, 12 mmol), Pd(PPh3)4 (231 mg, 1 mol%) in THE (90 mL) was stirred under Argon atmosphere at 70 °C for 0.5 h. Cooled to room temperature, poured into sat NaHCOs-solution, extracted with ether, washed with brine, dried over Na2SO4. Removal of the solvent in vacuum followed by siHca gel column chromatography with cydohexane/EtOAcleft a colorless oil (5.321 g).} (5.321 g, 20 mmol), Pd(PPh3)4 (693 mg, 3 mol%) and K2CO3 (5.53 g, 40 mmol) in toluene (100 mL), EtOH (9 mL) and H2O (20 mL) was stirred at 80 °C for 3.5 h. Cooled to room temperature, diluted witib EtOAc, washed with sat NaHCOs-solution and brine. dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by silica gd column chromatography with cydohexane/EtOAc] (2-330 g, 10.5 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HQ according to general procedme K (method d). Obtained as a brown oil (2.926 g> 82%). MS (EI) 339 (W). Example K36 3'f3-(2-Cyclopropyl-6-methyl-pyridin-4yl)-phenyl]-3-oxo-propionic add tert-butyl ester The tide compound was obtained from 3-(2-cyclopropyi-6-methyl-pyridin-4-yl)-benzonitrile [prepared by ihe following procedure: A mixture of 3-cyanophenylboronic add [CAS-No. 150255-96-2] (0.71 g, 4.8 mmol), 4-bromo-2-cydopropyl-6-methyl-pyridine {prepared by the following procedure: A mixture of 2,4-dibromo-6-methyl-pyridine [CAS-No. 79055-52-0] (1.00 g, 4.0 mmol), cydopropyizinc chloride (0.4 M in THF, 12.5 mL, 5 mmol), Pd(PPh3)4 (46 mg, 1 mol%) in THF (4.4 mL) was stirred under Argon atmosphere at 70 °C for 1 h. Cooled to room temperature, poured into sat NaHCOs-solution, ejctracted with ether, washed with brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown oil.} (ca. 4 mmol), Pd(PPh3)4 (139 mg, 3 mol%) and K2CO3 (1,11 g, 8.0 mmol) in toluene (22 mL), EtOH (1.8 mL) and H2O (4.5 mL) was stirred at 80 °C for 2 h. Cooled to room temperature, diluted with EtOAc, washed with sat NaHCOs-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown solid, which was purified by sflica gd column chromatography with cydohexane/EtOAc] (0.94 g, 4.0 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to generd procedure K (method d). Obtained as a yellow oil (1,17 g, 83%). MS(ISP)352[(M+H)1. Example K37 3-f3-r2-Isobutvi-pyridin-4-yD-phenvn-3"OXO-propionic add tert-butyl ester The title compound was prepared from commerdally available 3-cyanophenylboronic add [CAS-No. 150255-96-2] and 4-chloro-2-isobutyl-pyridine [D.L. Comins; J. Org. Chem. 50 (1985) 4410] according to general procedure K (method d; example K8). Obtained as a yellow oil. MS (ISP) 354.3 [(M+H)1. c) Reaction of (RS)-3-[2-(tetrahydro-pyran-2-yioxjrmethyl)-pyrid^ add methyl ester -with terL-butjd acetate according to general procedure K (method d; example K8) yielded the title compound as a light ydlow oil. MS (ISP) 412.2 [(M+HD. Example K41 3-[3-(6-Metfayl-pyrimidin-4-viVphen^1-3-oxo*propionic add tert-butyl ester The title compound was prepared from 3-(6-methyl-pyrimidin-4-yl)-benzoic add methyl ester ester [prepared by the follomng procedure: A solution of 3-dalorocarbon^-benzoic add methyl ester (19.9 g, 0.1 mol) in Et20 (20 ml) was added at 5 X to a solution of 3-oxo-butyric add tert-butjd ester magnesium salt [prepared from 3-oxo-butyric acid tert-butyl ester (13.4 ml, 82 mmol) and freshly prepared magnesium ethoxide [from Mg (2.65 g, 109 mol) in ethanol (25 ml) / Ca4 (0.5 ml) ] according to Helv. Chim. Acta 1952,35,2280]. The mixture was stirred at r.t for 15 h and then poured on sat NH4CI-S0I. The pH was set to 1.6 by the addition of 25% HCl and the mixture was extracted with EtaO. The orange oil (27 g) obtained was heated in toluene (400 ml) in the presence of p-TsOH monohydrate (0.69 g, 3.6 mmol) to 100 °C for 4 h. After cooling, the solvent was evaporated in vacuum and the residue was dissolved in AcOEt The solution was washed with saL NaHCOa-soL and brine, dried over Na2SO4 and evaporated in vacuxrai to give 3-(3-oxo-butyryl)-ben2oic add methyl ester (15.6 g). A sample of this material (3.0 g, 13.6 mmol) was stirred with 2N KOH (40 ml) at r.L for 10 min. The mixture was addified to pH 1 with 3N HCl and the predpitate was isolated by filtration and triturated with AcOEt to give 3-(3-oxo-butyryl)-benzoic add (2.3 g). A solution of this material (2.2 g, 11.0 mmol) in formamide (5.3 ml, 132 mmol) was heated to 180 *°C for 1 h. The mixture was cooled and partitioned between AcOEt and sat NaHCOs-sol. The aqueous phase was addified with 3N HCl to pH 2.6 and extracted with AcOEt and the crude product obtained was esterified by heating in MeOH (12 ml)/4N HCl-EtaO (3 ml) for 18 h at 40 °C to give the methyl ester as white crystals (0.33 g).] (0.8 g, 3.5 mmol) by treatment with Hthium tert-butyl acetate according to general procedure K (method b). Obtained as a light ydlow oil (1.34 g, crude product). Example K42 3-f3-(2-Methyl-pyrimidin-4-yl)-phenyll-3'OXO-propionic add tert-butyl ester The title compound was prepared fi:om 3-(2-methyl-pyrimidin-4-yl)-ben2oic add methyl ester [prepared by the following procedure: A mixture of 3-acetyl-ben2oic add (0.82 g, 5 mmol), N-(bis-acetylamino-methyl)-acetamide (0.94 g, 5 mmol) and cone. H2SO4 (0,01 ml) was heated to 155 °C for 6 h. The cooled mixture was diluted with H2O (20 ml) and the precipitate was collected, dried and esterified by heating in MeOH (12 ml)/4N HCl-Et20(3 ml) for 20 h at 40 °C; white crystals (0.27 g).] (0.80 g, 3.5 mmol) by treatment with Kthium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow solid (1.36 g, crude product). MS (ISP) 313.3 [(M+H)+]. Example K43 3-Oxo-3-(3-pyrimidin-4-yl-phenyl)-propionic acid tert-butyl ester The title compound was prepared from 3-pyrimidin-4-yl-benzoic add methyl ester [prepared by the following procedure: A mixture of 3-acetyl-benzoic acid (2.46 g, 15 mmol), N-(bis-form^damino-methyl)-formamide (2.18 g, 15 mmol) and cone, H2SO4 (0.1ml) were heated to 155 °C for 3 h. The cooled mixture was diluted with H2O (20 ml) and the precipitate was collected, dried and esterified by heating in MeOH (12 ml)/4N HCl-Et20 (3 ml) for 20 h at 40 °C; white solid (1.06 g).] (0.90 g, 4.2 mmol) by treatment with Hthium tert-butyl acetate according to general procedure K (mefliod b). Obtained as a light yellow oil (1.58 g, crude product). MS (ISP) 299.4 [(M+H)+]. Example K44 3-Oxo-3-f 3-pvrimidin-2-yl-phenyl)-propiomc acid tert-butyl ester The tide compound was prepared from 3-pyrimidin-2-yl-benzoic acid methyl ester [prepared by the following procedure: 3-Pyrimidin-2-yl-ben2oic add (3.0 g) was esterified by heatmg in MeOH (160 ml)/4N Ha-Et2O(40 ml) for 16 h at 40 °C; white crystals (1.99 g).] (1.99 g, 9.3 mmol) by treatment with Hthium tert-butyl acetate according to general procedure K (method b). Obtained as a light yellow oil (3,24 g, crude product). MS (ISP) 299,4 [(M+H)1. Example K45 3-[3-(2-Amino-6-methyl-pyrimidin-4-yl)-phenvn-3-oxo-propionic add tert-butyl ester The title compound was prepared from 3-(2-amino-6-methyl-pyrimidin-4-yl)-benzoic acid methyl ester [prepared by the following procedure: To a solution of 3-(3-oxo-butyryl)-ben2oic add (2.06 g, 10 mmol) and guanidine hydrochloride (0.96 g, 10 mmol) °C to a solution of hydrazinecarboxyiic add tert-butjd ester (19.9 g, 0.1 mol) and pyridine (13.3 ml, 0.165 mol) in Et2O(0.61). The mixture was stirred for 1 h at 0 °C and for 1 h at r.t, diluted with AcOEt and washed successively with IN HCl, sat. NaHCOs- soL and brine. The organic layer was dried and evaporated to give 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-benzoic add (31.5 g) as white solid. A sample of this material (29.4 g, 0.1 mol) was stirred in a mixture of MeOH (0.11) and 1 N KOH (0:21) for 18 h at r.t The solution was concentrated in vacuum and then washed with AcOEt The aqueous phase was addified to pH 1 vrith 3N HCl and the predpitate formed was isolated by filtration, dried and then stirred with TFA (0.31) at r.t for 40 min. The mixture was evaporated in vacuum and the residue was triturated with EtaO/EtOH (10:1) to give 3-hydrazinocarbonyl-benzoic add as a white solid (16.2 g). A solution of this material (3.6 g, 20 mmol) and 1,3-butandione (1.89 g, 22 mmol) in MeOH (20 ml) was stirred at r.t for 1 h. The mixture was evaporated in vacuum and the residue wzs heated in an autodave in 5N NHs-MeOH (30 mL) at 150 °C for 3 h. The mixture was cooled and partitionned between AcOEt and sat NaHCOs-solution. The aqueous phase was addified to pH 3 with 3N HCl and extracted with AcOEt The crude product obtained from the AcOEt extract was esterified by heating in IN HQ-MeOH (80 mL) for 18 h at 50°C. The crude product was purified by diromatography (silica gd, AcOEt) to give the methyl ester as Hght yellow solid (1.21 g).] (1.21 g, 5 romol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a li^t brown solid (1.78 g, crude product). MS (ISP) 328.4 [(M+H)+]. Example K48 3-r3-f6-Methvl-dimethvlamino-pvrinudin-4-vIVphenyl1"3-oxO"propionic acid tert-butyl ester The title compound was prepared from 3-(2-dimethylamino-6-met]iyl-pyrimidin-4'-yl)-benzoic add methyl ester [prepared by the following procedure: A mixture of NaH (50% dispersion in mineral oil, 1.56 g, 32.5 mmol) in 2-propanol (45 ml) was stirred at 50 °C for 10 min. N-methylguanidine hydrochloride (3.3 g, 30 mmol) was added and stirring was continued for 10 min. After the addition of 3-(3-oxo-butyryl)-benzoic add (3.1 g, 15 mmol), the mixture was stirred at 80 °C for 48 h. After cooling to r.t, H2O (100 ml) was added and the mixture was concentrated in vacuum to a volmne of ca. 80 mL The pH was set to 2.5 with 25% HCl and the predpitate was collected, dried and then esterified by stirring in IN HCl-MeOH (30 ml) for 60 h at r.t. The crude product was purified by t chromatography (silica gel, AcOEt) to give the methyl ester as Hght yellow solid (0.27 g).] (0^6 g, 1 mmol) by treatment "with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a light ydlow oil (0.38 g, crude product). Example K49 3-r3-(6-Metfavl-2-dimethvlamino-pvrimidin-4-vIVphenyl1>3-oxo-propionic acid tert-butyl ester The title compound was prepared from 3-(2-methylanaino-6-methyl-pyrimidin-4-yl)" benzoic add methyl ester [prepared by the following procedure: A mixture of NaH (50% dispersion in mineral oil, 1.56 g, 32.5 mmol) in 2-propanol (45 ml) was stirred at 50 °C for 10 min. 1,1- Dimethylguanidine sulfate (4.08 g, 15 mmol) was added and stirring was continued for 10 min. After the addition of 3-(3-oxo-butyr5d)-ben2oic add (3.1 g, 15 mmol), the mixture was stirred at 80 °C for 40 h. After cooling to r.t, H2O (100 rd) was added and the mixture was concentrated in vacuum to a volume of ca. 80 ml. Hie pH was set to 2.8 with 25% HQ and the predpitate formed was collected, dried and then esterified by stirring in IN HCl-MeOH (30 mL) for 18 h at r.t The crude product was purified by chromatography (silica gel, AcOEt) to give the methyl ester as white solid (0.49 g).] (0.48g, 1.77 mmol) by treatment with Uthium tert-butyl acetate according to general procedure K (method b). Obtained as a yellow oil (0.70 g, crade product). MS(ISP)3562[(M+H)1. Example K50 3-(3-r2-(2-Hvdroxv-ethvlaminoV6-methvl-pyriTnidin-4-vl1-pfaenvl>-3H3xo-pr^^^ acid tert-butyl ester The title compound was prepared from rac-3-{6-methyl-2-[2-(tetrahydro-pyran-2-yloxy)-ethylaniino]"pyriimdin-4-yl}-benzoic add methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboronic add (8.3 g, 50.0 namol), 2,4-dichloro-6-methylpyrimidine (8.15 g> 50.0 mmol) and NaaCOs (9.5 g, 90 mmol) in acetonitrile (160 ml)/H2O (80 ml) was degassed and Pd(PPh3)4 (0.87 g, 0.75 mmol) was added. The mixture was stirred for 18 h at 85 °C in an atmosphere of nitrogen and then concentrated in vacuxmi to a volume of ca.100 ml H2O (100 ml) was added and the mixture was washed with AcOEt (50 ml). The pH of the aqueous phase was set to 2.5 by addition of 25% HCl and the predpitate was collected and dried to give 3-(2-chloro-6-methyl-pyrimidin-4-yl)-benzoic add (9.1 g) as a white solid A sample of this material (1.49 g, 6 mmol) was heated in 2-amino-ethanol (3.6 ml) at 80 °C for 1 h. The mixture was evaporated in vacuum and the residual oil was stirred in IN HCl-MeOH (20 ml) for 18 h at 40 °C. The crude product (1.36 g) and 3,4-dihydro-2H-pyran (0.86 ml, 9.5 mmol) were stirred in AcOEt (10 mL)/4N HCl-Et20(l,3 ml) for 4 li at r.t The mixture was diluted with AcOEt and washed with sat NaHCOs-soL and brine. The organic layer was dried over Na2SO4, evaporated in vacuum, and the residue was purified by chromatography (silica gd, AcOEt/hexane 1:1) to give the methyl ester as Hght yellow oil (1.53 g).] (1.53g, 4.1 mmol) by treatment with lithium tert-butyl acetate according to general procedmre K (method b). Obtained as a Hght ydlow oil (1.62 g), MS (ISP) 456.4 [(M+H)+]. Example K51 3-i 3-r2-(2-Methoxy-ethvlamino)-6-methyl-pvrimidin"4-vl1-phenyl 1-3-oxo-propionic acid tert-butyl ester The tide compound was prepared from 3-[2-(2-methoxy-ethylamino)-6-mediyl-pyrimidin-4-yl]-benzoic add methyl ester [prepared by the following procedure: 3-(2-Chloro-6-method-pyrimidin-4-)d)-benzoic acid (1.49 g, 6 mmol) was heated in 2-methoxy-ethylamine (5.2 ml) to 80 °C for 2.5 h. The mixture was evaporated in vacuimi and the residual oil was stirred in IN HQ-MeOH (20 ml) for 18 h at 40 °C to give the methyl ester as Kght yellow solid (1.29 g).] (1.29 g, 4.3 mmol) by treatment with hthium tert-butyl acetate according to general procedure K (method b). Obtained as a Hght yellow oil (1.44 g). MS (ISP) 386.3 [(M+H)+]. Example K52 3-r3-f6-Methvl-2-morpholin-4-vl-pvrimidin-4-vlVphenyl1-3-oxo-propiomc acid tert-butyl ester The title compound was prepared from 3-(2-morpholin-4-yl-pyrimidin-4-yl)-benzoic add methyl ester [prepared by the following procedure: 3-(2-Chloro-6-medi)i-pyrimidin-4-yl)-benzoic add (1.49 g, 6 mmol) was heated in morpholine (5.2 ml) to 120 °C for 16 h. The mixture was evaporated in vacuxmi and the residual oil was stirred in IN HCl-MeOH (20 ml) for 20 h at 40°C to give the methyl ester as Hght yellow solid (1-19 g).] (1.13 g, 4.3 mmol) by treatment with Hthium tert-butyl acetate according to general procedmre K (method b). Obtained as a Hght yellow solid (1.66 g). MS (ISP) 398.5 [(M+H)'], Example K55 3,r3-(6'DimethvlaimDo-pyriTnidin-4-vlVphen acid tert-butyl ester The title compound was prepared from 3-(2-morpholin-4-yl-pyrimidin-4-yl)-benzoic acid methyl ester [prepared by the following procedure: 3-(6-Chloro-pyrimidin-4-3d)-benzoic add (1.0 g, 4.3 mmol) was heated in 5.6M dimethylamine-EtOH (5 ml) to 80 °C for 1.5 h. The mixture was evaporated in vacuum and the residual oil was stirred in IN HCl-MeOH (10 ml) for 72 h at 50 °C. The crude product was purified by chromatography (silica gd, AcOEt) to give the methyl ester as yellow solid (0.43 g).] (0.39 g, 1.5 mmol) by treatment with Hthium tert-butyl acetate according to general procedure K (method b). Obtained as a li^t yellow solid (0.45 g). MS (ISP) 342.3 [(M+H)+]. Example K56 3-13- [6"(2-Methoxy-ethvlamino)-pyriniidin-4-yl1-phenvil-3-oxo-propionic acid tert-butyl ester The title compound was prepared from 3-[6-(2-methoxy-ethylamino)-pyrimidin-4-yl]-benzoic add methyl ester [prepared by the following procedure: 3-(6-Chloro-pyrimidin-4-yl)-benzoic acid (1.0 g, 4.3 mmol) was heated in 2-metiioxy-efliylamine (5 ml) to 80 °C for 1 h. The mixture was evaporated in vacuum and the residual oil was stirred in IN HQ-MeOH (25 mL) for 18 h at 50 °C. The crude product was purified by chromatography (silica gd, AcOEt-hexane 1:1) to give the methyl ester as Kght yellow solid (0.67 g).] (0.66 g, 2.3 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a Ught yellow oil (0.93 g, not pure). MS (ISP) 372.3 [(M+H)+]. Example K57 3-r231Bipyridinyl-4-yl-3-oxo-propionic acid tert-butyl ester The title compound was prepared from [2,3']bipyridinyl-4-carboxylic acid methyl ester [prepared by the following procedure: A mixture of pyridine-3-boronic acid (0.7 g, 5.7 mmol), 2-bromo-isonicotinic add (1.15 g, 5.7 mmol) and K2CO3 (0.63 g, 4.6 mmol) in CH3CN (120 mL) /H2O (10 mL) was degassed and Pd(PPh3)4 (0.13 g, 0.11 mmol) was added. The mixture was stirred for 24 h at 80 °C in an atmosphere of nitrogen and then concentrated in vacuum to a volume of ca, 10 mL The pH was set to 6 by addition of 3N HCl and the solution was then evaporated in vacuum to dryness. The residue was stirred in IN HCl-MeOH (23 ml) for 65 h at 50 °C The crade product was purified by chromatography (silica gd, AcOEt/cydoheacane 1:1) to give the methyl ester as Kght ydlow oil (0.37 g),] (044 g, 2.1 mmol) by treatment \vi1h Uthium tert-butyl acetate according to general procedure K (me&od b). Obtained as a light yellow oil (0.62 g, crude product). MS (ISP) 299.3 [(M+H)+]. Example K58 3-r2.41Bipyridinvl-4-yl-3-Oxo-propiomc acid tert-butyl ester The tide compound was prepared from [2,4']bipyridinyl-4-carboxylic add method ester [prepared by the foflowing procedure: A mixture of pyridine-4-boronic add (0.7 g, 5.7 mmol), 2-bromo-isonicotinic add (1.15 g, 5.7 mmol) and K2CO3 (0.63 g, 4.6 mmol) in CH3CN (120 ml) /H2O (10 ml) was d^assed and Pd(PPh3)4 (0.13 g, 0.11 mmol) was added. The mixture was stirred for 24 h at 80 X in an atmosphere of nitrogen and then concentrated in vacuiun to a volume of ca. 10 ml. The pH was set to 6 by addition of 3N HCl and the solution was then evaporated in vacuum to dryness. The residue was stirred in IN HCl-MeOH (23 ml) for 65 h at 50°C The crade product was purified by chromatography (silica gd, AcOEt/cydohesane 1:1) to give the methyl ester as light yellow oil (037 g).] (0.21 g, 1.0 mmol) by treatment with Uthium tert-butyl acetate according to general procedure K (method b). Obtained as a light yellow oil (0.45 g, crade product). MS (ISP) 299.3 [(M+H)+']. Example K59 3-(2-Methvl-r2,41bipyridipvl-4-ylV3-oxo-propionic acid tert-butyl ester The title compound was prepared from 2'-methyl-[2,4']bipyridinyl-4-carboxylic add methyljd ester [prepared by the following procedure: A cooled solution o( 4-bromo-2-methyl-pyridine (2.75 g) in EtaO (26 ml) was added at -78 °C over to a solution of 1.6 M butyl lithium/hexane (12 ml) in EtaO (50 ml). The solution was stirred for 20 min at -78 °C. Triisopropylborate (4.8 ml, 20.8 mmol) was added and the mixture was allowed to warm up to r.t over 1 hour and subsequently stirred for 18 h. H2O (13 ml) was added and the layers were separated. The organic layer was extracted with 0.5N NaOH (25 ml) and the combined aqueous layers were acidified to pH 6 with 2N HCl and then extracted with AcOEt (200 ml). The organic extract was dried and evaporated in vacuum and the residue was triturated with EtaO to give pyridine-2-methyl-4-boronic add (0.36 g). A mixture of this material (0.36 g, 2.6 mmol), 2-bromo-isoiiicotinic add (0.53 g, 2.6 mmol) and K2CO3 (0.29 g, 2.1 mmol) in CH3CN (9 ml) /H2O (4.5 ml) was degassed and Pd(PPh3)4 (0.12 g, 0.1 mmol) was added. The mixture was stirred for 70 h at 80 X in an atmosphere of nitrogen and then concentrated in vacuum to a volume of ca. 5 mL The pH was set to 6 by addition of 3N HQ and the solution was then evaporated to dryness in vacuuHL The residue was stirred in IN HQ-MeOH (30 ml) for 20 h at 50°C The crude product was purified by chromatography (silica gd, AcOEt/cydohexane 1:1) to give tibie method ester as light yellow oil (0.22 g).] (0.16 g, 0.71 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a white solid (0.38 g). MS (ISP) 313.3 [(M+H)+]. F.Yample K60 3-f3-f2-Cvclopropyi-pyridin-4-yl)-phenvn-3-Qxo-propionic add tert-butid ester The title compound was obtained from 3-(2-cydopropyi-pyridin-4-yl)-benzonitrile [prepared by the following sequence: 1.) A mixture of 3-cyanophenylboronic add [CA.S-No. 150255-96-2] (23.14 g, 158 mmol), 2-chloro-4-iodo-pyridine [CAS-No. 153034-86-7] (35.92 g, 150 mmol), NaHCOs (30.24 g, 360 mmol) and PPhs (1.31 g, 3.3 mol%) in DME (750 mL) and H2O (360 mL) was thoroughly degassed at 23 °C before Pd(0Ac)2 (337 mg, 1 mol%) was added and the mixture was refluxed for 5 h. Poured onto ice, saturated with solid NaCl, extracted with EtOAc (2 x 1000 mL), dried the combined organic layer over Na2SO4. Removal of the solvent in vacuum left a yellow solid. Dissolved in hot EtOAc (ca. 200 mL), added heptane (ca. 350 mL), allowed to cool to rt, filtered predpitate off, washed with heptane/EtOAc 3:2, dried in HV to give a light yellow solid (28.11 g). 2.) A mixture of the resulting 3-(2-chloro-pyridin-4-yl)-benzonitrile (4.29 g, 20 mmol), cyclopropyizinc chloride (0.4 M in THF, 62.5 mL, 25 nrnaol), Pd(PPh3)4 (690 mg, 3 mol%) in THF (22 mL) was stirred under Argon atmosphere at 70 °C for 2 h. Cooled to room temperature, poured into sat NaHCOs-solution, extracted with ether, washed with brine, dried over Na2SO4, Removal of the solvent in vacuum left a light yellow solid (2,98 g).] (3.19 g, 14.5 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as a yellow oil (3.37 g, 69%). MS(ISN)336[(M-Hr]. Example K61 3-[3-f2-Cvclopentid-pyridin-4-v1)-phenyl1"3-oxo-propionic add tert-butyl ester The title compound was obtained from 3-(2-C7dopentyi-pyridin-4-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-(2-diloro-pyridin-4-yl)-benzonitrile (cf. Example K60) (4.29 g, 20 mmol), cydopentylzinc bromide (0.5 M in THE, 50 mL, 25 mmol), Pd(PPh3)4 (690 mg, 3 mol%) in THE (20 mL) was stirred under Argon atmosphere at 70 °C for 2 h. Cooled to room temperature, poured into sat NaHCOa-solution, extracted with ether, washed with brine, dried over Na2SO4. Removal of the solvent in vacumn followed by sflica gd colunan chromatography left an orange oil (L63 g).] (1.60 g, 6.44 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as a ydlow oil (1.45 g, 62%). MS (ISN) 364.3 [(M-H)']. Example K62 3-[3-(2-Morpholin-4-yl-pyridin-4-yl-phenyl]-3-oxo-propionic add tert-butyl ester The title compound was obtained from 3-(2-morpholin-4-yl-pyridin-4-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-(2-chloro-pyridin-4-yl)-benzonitrile (cf. Example K60) (3 x 800 mg, 11.81 namol) and morpholine (3x4 mL, 137.74 mmol) was irradiated in the microwave at 200 °C for 15 min each. The mixtures were poured into water and extracted with EtOAc, the organic layer was washed with brine and dried over MgSO4- Removal of the solvent in vacuum followed by silica gd column chromatography left a white solid (2.08 g).] (2.00 g, 7.54 mmol) by treatment with tert-butyl bromoacetate and activated zinc, followed by hydrolysis with 10% HCl according to general procedure K (method d). Obtained as a yellow oil (2.60 g, 90%). MS (ISP) 383.3 [(M+H)+]. Example K63 3-0x0-3-f3-(2-pvrrohdin-l-yl-pyridin-4-yl)-phenyl1-propionic acid tert-butyl ester The title compound was obtained from 3-(2-pyrrolidin-l-yl-pyridin-4-yl)-benzonitrile [prepared by the following procedure: A mixture of 3-(2-chloro-pyridin-4-yl)-benzonitrile (cf Example K60) (3.59 g, 16.72 mmol) and pyrrolidine (15 mL) was irradiated in the microwave at 200 °C for 4-15 min. The mixtures were poured into water and extracted with EtOAc, the organic layer was washed with brine and dried OVCT The following methods rdate to the preparation of the 6-aryl-2,2-dimethyl-[13] General procedure L Preparation of 6-arvl-2.2-dimethyl- [ 13] dioxm-4-ones Method a) The 6-aryl-2,2-dimethyl-[l,3]dioxin-4-ones were prepared from 3-aryl-3-oxo-propionic acids and catalytic amoimt of cone. H2SO4 or trifluoroacetic acid (TFA) in isopropenyl acetate at 23 °C according to Chetn. Pharm. BuU. 1983,31y 1896. The final products were pmified by silica gel column chromatography with hexane/EtOAc. Method b) The 6-aryl-2,2-dimethyl-[l,3]dioxin-4-ones were prepared from the tert-butjd 3-aryl-3-oxo-propionates by treatment with trifluoroacetic anhydride (TFAA) in a mixture of TFA and acetone at 23 X according to Tetrahedron Lett. 1998,39,2253. The final products were if necessary purified by silica gd column chromatography with hexane/EtOAc. General procedure M Preparation of l2-f3-aryl-3-oxo-propionylamino]-phenyll-carbamic add tert-butyl esters by reaction of f 2-amino-phenyl)-carbamic add tert-butyl esters with ethyl or tert-butyl 3-arvl-3-oxo-propionates or 6-aryl-Z2-dimethvl--f 13ldioxin-4-ones A mixture of the (2-amino-phenyl)-carbamic add tert-butyl ester or (1.0-1.2 mmol) and (1.0-1,5 mmol) of the ethyl or tert-butyl 3-aryl-3-oxo-propionate or 6-aryl-2,2-dimethyl-[1,3] dioxin-4-one was heated in toluene or x)dene (4-8 mL) to 80 °C to 150 °C until tic indicated complete consumption of the minor component The solution was allowed to cool to 23 °C, whereupon the product generally crystallized (in cases where crystallization failed to appear it was induced by addition of hexane or ether, alternatively the reaction mixture was directly subjected to silica gel column chromatography). The solid was filtered off, washed with ether or mixtures of ether/hexane and dried in vacuum to give the {2-[3-aryl-3-oxo-propionylamino]-phenyl}-carbainic add tert-butyl esters, which was used directly in the following step or - if necessary - was purified by recrystaUization or by siHca gd column chromatography. Example Ml (5-Dimethylamino-2-[3-oxo-3-(-3pyridin-3-yl-phenyl-propionylaminol -4-trifluromethyl-phenyl]-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-dimethylamiiio-4-trifluoromethyl" phenyl)-carbamic addtert-butjd ester (Example Jl) (262 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-plien]d)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a pink foam (335 mg), MS (ISP) 543.3 [(M+Hfj. Example M2 (5-Dimethylamino-2-r3-oxo-3-(^-pyridin-4-yl-phenyl)-propionvlaniinol-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound wss prepared from (2-amino-5-dimethylainino-4-trifluoromet]ij4-phenyl)-carbamic add tert-butyl ester (Example Jl) (239 mg, 0,75 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (&cample K2) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an orange solid (324 mg). MS (ISN) 541 [(M-H)-]; mp 161 °C. Example M3 {5-Dimethvlaniino-2-r3-oxo-3-(3-pyridin-2-yl-phen-\d)-propion-sdainino]-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-dimethylamino-4-trifluorometh]4-phenyl)-carbamic add tert-butyl ester (Example Jl) (239 mg, 0.75 mmol) and 3^oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a pink solid (295 mg). MS (ISN) 541.0 [(M-H)']; mp 169 °C Example M4 l4-Fluoro-2-f3-oxo-3-f3-pyridin-3-vl-phenyD-propionylaniiTin]-phenyU-carbamicacid tert-butyl ester The title compound was prepared from (2-amino-4-fluoro-phenyl)-carbamic acid tert-butyl ester (Example J2) (83 mg, 0.37 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)- propionic add tert-butyl ester (Example Kl) (109 mg, 0.37 mmol) according to the general procedure M. Obtained as a light yellow amorphous substance (127 mg). MS(ISP)450[(M+Hf]. Example M5 U-Fluoro-2-r3-oxo-3-f3-pyridin-4-yl-phenylVpropinny1aTnmol-phenyU-carbamica tert-butyl ester The title compound was prepared from (2-amino-4-fluoro-phenyl)-carbamic acid tert-butyl ester (Example J2) (170 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (251 mg). MS (ISP) 450.4 [(M+H)+]; mp 110-115 °C Example M6 (2-{3-[3-(6-Methvi-pyridin-3-ylVphenyl1-3-oxo-propionylaminol-4-trifluoromethvl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a white solid (399 mg). MS (ISN) 512.2 [(M-H)-]; mp 74-76°C Example M7 f5-Dimethvlaniino-2-{3-[3-(6-methyl-pyridin-3-vD-phenyl1-3-oxo-propionylaminol-4-trifluoromethvl-phenylVcarbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-dimethylamino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example Jl) (239 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a pink solid (358 mg). MS (ISN) 555.1 [(M-H)-]. Example M8 (4-Huoro-2-l3-f3-f6-methyl-pyridin-3-ylVphenyll-3-oxo-propionylammo-phenyl carbamic acid tert-butyl ester The tide compoiind was prepared from (2-amino-4-£luoro-phen7l)-carbamic add tert-butyl ester (Scample J2) (170 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxopropionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (323 mg). MS (ISN) 462.5 [(M-H)']. Example M9 f2'-Huoro-3-{3-r3-(6-methv]-pyridin-3-yl)-phenyll-3-oxo-propionylaniinoKbiphenyl-4-yl-carbaTm'r flrjd tert-butyl ester The title compound was prepared from (3-amino-2'-fluoro-biphenyl-4-yl)-carbamic add tert-butyl ester [CAS-No. 335255-65-7] (227 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow solid (347 mg). MS (ISN) 538.2 [(M-H)']; mp 86-88 °C Example MIO (5-DimethvIamino-2-l3-[3-(2-methvl-pyridin-3-vlVphenyll-3-oxo-propionv1aniinn}--4-trifluoromethvl-phenyl-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-5-dimeth)damino-4-trifluorometh)d-phenyl)-carbamic add tert-butyl ester (Example Jl) (239 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K5) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a pink solid (389 mg). Mp 87-91 °C. Example Mil f2-l3-r3-(6-Methyl-pyrida2in-3-yl-phenyl1-3-oxo-propionvlaminol"4-trifluoromethyl-phenyP-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3- [3-(6-methyl-pyridazin"3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K6) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (332 mg). MS (ISP) 515 [(M+H)+]; mp 174 °C. Example M12 (5-Dimethylamino-2-l3-f3-(6-methyl-pyrida2in-3-yiVphenyl1-3-oxo-propiony 4-trifLuorometfayl-phenyl)-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-dimethylanMno-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example Jl) (239 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K6) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (254 mg). MS (ISP) 558 [(M+H)+]; mp 145 °C Example M13 (2'-HuorO"3-l3-f3-(6-methyl-pyridazin-3-ylVphenyl]-3-oxo-propionylaminol-biphenyl-4-yl)-carbamic add tert-butyl ester The title compound was prepared from (3-amino-2'-fluoro-biphenyl-4-]4)-carbainic add tert-butyl ester [CAS-No, 335255-65-7] (227 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (jfeample K6) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow • substance (330 mg). MS (ISP) 541 [(M+H)1. Example M14 f2-!3*r3-(2-Metfayl-pyridin-3*ylVphenyl1-3-oxO"propionvlairiinn}>4-iTi phenyP-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) (207 mg> 0.75 mmol) and 3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (ficample K5) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow oil (322 mg). MS (ISP) 514.3 [(M+H)+]. Example M15 (4-Fluoro-2-l3- [3-f 2-methyl-pyridin-3-yl Vphen^l -3-oxo-propion^aminol-phenyD-carbamic acid tert-butyl ester The title compound was prepared from (2-ainino-4-fluoro-phenyl)-carbamic add tert-butyl ester (Example J2) (170 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K5) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (308 mg). MS (ISP) 462.2 [(M+H)+]; mp 74-78 °C. Example M16 (2-FluoTO-3-l3-r3-f2"methyl-pyridin-3-ylVphenyl1-3-oxo-propionyiaminol-biphenyl-4-yl)-carbamic add tert-butyl ester The title compound was prepared from (3-amino-2'-fluoro-biphenyl-4-yl)-carbamic add tert-butyl ester [CAS-No. 335255-65-7] (227 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K5) (234 mg, 0.75 nrniol) according to the general procedure M. Obtained as a yellow solid (381 mg). MS (ISP) 538.2 [(M+H)+]; mp 48-54 °C. F.YampleMl? l2-r3-Cbco-3-(3-pyriciin-4-^-phenyD-propionvlamino]-4-trifl^ carbamic acid tert-butyl ester The title compound was prepared from (2-ainino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) and and 3-oxo-3-(3-pyridin-4-yl-pben7l)-propiomc add tert-butyl ester (Ifeample K2) according to the general procedure M. Obtained as a white solid (275 mg). MS (ISP) 500 [(M+H)+]. Example M18 (2'-Fluoro-3- [3-oxo-3- f 3-pyridin-4-yl-phenylVpropionylainino1 -biphenyl-4-vU-carbamic add tert-butyl ester The title compound was prepared from (3-amino-2'-fluoro-biphenyl-4-yl)-carbamic add tert-butjd ester [CAS-No. 335255-65-7] and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) according to the general procedure M. Obtained as a yellow solid (410 mg). MS(ISP)526[(M+Hr]. Example M19 l4-Chloro-2- f 3-oxo-3-f 3-pyridin-4-yl-phenyl)-propionylamino1 -phen'^l-carbamic add tert-butyl ester Prepared from (2-amino-4-chloro-phenyl)-carbamic add tert-butyl ester (Example J4) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) according to the general procedure M. Obtained as a yellow solid (270 mg). MS (ISP) 466 [(M+H)+] and468 [(M+2+H)']. Example M20 (4-Chloro-5-fIuoro-2-B-f3-(6-methyl-pyridin-3-ylVphenyl1-3-oxo-propionvlamino}-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-fluoro-phenyl)-carbamic add tert-butyl ester (Example J5) (235 mg, 0.9 mmol) and 3-[3-(6-methyl-pyridin-3-yl)- phenyl]-3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0,75 imnol) according to the general procedure M. Obtained as an off-white foam (257 mg), MS (ISN) 496,1 [(M-H)-] and498 [(M+2-H)-]; mp 76-80 X, Example M21 l4-CHoro-5-fIuoro-2-f3-oxo-3-f3-pyridin-4-yl-phenyl)-propiQnvlamiTio1-phenyl>-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-4-chloro-5-fluoro-phenyl)-carbamic add tert-butyl ester (Example J5) (235 mg, 0.9 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a pink powder (272 mg), MS (ISN) 482.2 [(M-H)'] and484 [(M+2-H)"]; mp 170-174^0. Rjcample M22 (4-Methyl-2- r3-oxo-3-(3-pyridin-3-yl-phen^Vpropionylamino1 -5-trifiuoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J23) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) according to the general procedure M. Obtained as a white solid (229 mg). MS (ISN) 512 [(M-H)-]. Example M23 l4-CHoro-5-methyl-2-r3-oxo-3-f3-pyridin-3-yl-phenyl)-propionvlaniin'o1-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-mediyl-phenyl)-carbamic add tert-butyl ester (Example J22) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) according to the general procedure M. Obtained as a yellow solid (310 mg). MS (ISP) 480 [(M+H)'] and 482 [(M+2+H)+]. Example M24 l2-f3-Oxo-3-(3"pyridm-3-yl-phenyD"propionvlamino1-4-t^ carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butjd ester (Example J3) and 3-oxo-3-(3"pyridin-3-^-phenyl)-propionic add tert-butyl ester (Example Kl) according to the general procedure M, Obtained as a l^t brown solid (303 mg), MS(ISP)500[(M+Hr]. Example M25 U-Chloro-2- [3-oxo-3-f 3-pyridin-3-yl-phenylVpropinTiy1amino1 -phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-diloro-phenyl)-carbamic add tert-butyl ester (Example J4) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) according to the general procedure M. Obtained as a light brown solid (227 mg). MS (ISP) 466 [(M+H)+] and 468 [(MH-2+H)^]. Example M26 l2'-Huoro-3-f3-oxo-3-(3-pyridin-3-vl-phenylVpropionyiamino1-biphenyl-4-yl}-carbamic add tert-butyl ester The title compound was prepared from (3-amino-2*-fluoro-biphenyl-4-yl)-carbamic add tert-butyl ester [CAS-No. 335255-65-7] and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) according to the general procedure M. Obtained as a light brown solid (198 mg). MS (ISP) 526 [(M+H)+]. Example M27 f2-f3-Oxo-3-(3-pyridin-3-yl-phenylVpropionviammo1-5-(2^,2*trifluoro-e& tri£Liioroinethyl-phenyl]-carhamtc add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-tiifluoro-et±ioxy')-4-trifluoromethyl-plienylj-carbamic add tert-butyl ester (Example J6) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) according to the general procedure M. Obtained as a light yellow solid (331 mg). MS(ISP)598[(M+Hr]. Example M28 (4-Chloro-2-l3- [3- f 6-methyl-pyridin-3-vD-phenyl1 -3-oxo-propion^aminol-phenyl V carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-diloro-phenyl)-carbamic add tert-butyl ester (Example J4) (182 mg, 075 mmol) and 3-[3-(6-me1ii)d-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Sample K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous light brown substance (316 mg). MS (ISN) 480 [(M-H)-] and482 [(M+2-H)-]. Example M29 (4-CMoro-2-l3-[3-f2-methyl-pyridin-3-yl-phenylnAd1-3-oxo-propionvlainino}-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-diloro-phenyl)-carbamic add tert-butyl ester (Example J4) (182 mg, 0,75 mmol) and 3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K5) (234 mg, 0.75 nmaol) according to the general procedure M. Obtained as an amorphous light brown substance (286 mg). MS (ISN) 480 [(M-H)-] and 482 [(M+2-H)"]. Example M30 12" [3-0x0-3- f3-pyridin-2-yl-phenyD-propionvlaminn] -4-trifluoromethyl-phenyll-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a white solid (284 mg). MS (ISN) 498.1 [(M-H)1; mp 70-73 °C. Example M31 {5-Methoxy-2- f 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino1 -4-trifluoromeflrsd-phenyll-carbamic add tert-but^ ester The title compound was prepared from (2-amino-5-methoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J7) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) according to the general procedure M. Obtained as a light yellow solid (271 mg). MS (ISP) 530.2 [(M+H)+]; mp 179 °C (dec). Example M32 l5-Ethoxy-2- [3-oxo-3-(3-pyridin-4-yl-phenyD-propionyiamino] -4-trifluoromethvi-phenyU-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J8) and 3-oxo-3-(3-pyridin-4-3d-phenyl)-propionic add tert-butyl ester (Example K2) according to the general procedure M. Obtained as a light yellow solid (271 mg). MS (ISP) 544.2 [(M+H)1; mp 165 °C (dec). Example M33 f2-f3-Oxo-3-(3-pyridin-4-yl-phenyl)-propionvlamino1-5-(2.2.2-trifluoro-etfaoxy)-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-ainino-5-(2>2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) and 3-oxo-3-(3- P7ridin-4-yl-phenyl)-propionic add tert-butjd ester (Example K2) according to the general procedure M. Obtained as a Ught yellow solid (299 mg), MS (ISP) 598.0 [(M+H)1; mp 173 °C (dec). Example M34 l4-Methoxy-2- f 3-oxo-3-(3-pyridin-4-yl-plienyiVpropionyiamino1 ■phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-methoxy-phenyl)-carbamic add tert-butjd ester (Example J9) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) according to the general procedure M. Obtained as a light yellow solid (258 mg). MS (ISP) 462.3 [(M+H)+]; mp 148-150 °C Example M35 ^2-DimethYlaminn-2'-fluoro-5-r3-oxo-3-f3-pyridin-4-^-phenylVpropionylaminol-biphenyl-4-yll-carbamic add tert-butyl ester The title compound was prepared from (5-amino-2-dimethylamino-2'-fluoro-biphenyl-4-yl)-carbamic add tert-butyl ester (Example JIO) (271 mg, 0.78 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (194 mg, 0.65 mmol) according to the general procedure M. Obtained as a yellow solid (316 mg). MS (ISN) 567.1 [(M-H)']; mp 105-110 °C. Example M36 f5-Dimetfa^amino-2-f3-r3-f6-metfaoxv-pYrida7in-3-yl)-phenyl1-3-oxo-propionylamino}-4-trifluoromethvl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-dimethylamino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example Jl) (239 mg, 0.75 mmol) and 3-[3-(6-methox7-pyridazin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K7) (246 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (317 mg). MS (ISP) 574 [(M+H)+]; mp 100-145 °C Example M37 (2'-Fluoro-3"l3-[3-(6-medioxv-pyridazin-3*yiVphen\dl-3-oxo-propionykminol^ biphenyl-4-vD-carbamic add tert-butyl ester The title compound was prepared from (3-ammo-2'-fluoro-biphenyl-4-yl)-cafbamic add tert-butyl ester [CAS-No. 335255-65-7] (227 mg, 0.75 imnol) and 3-[3-(6-methoxy-pyridazm-3-yl)-phen^]-3-oxo-propionic add tert-butyl ester (Example K7) (246 mg, 0.75 mmol) according to the general procediire M. Obtained as an off-white amoiphous substance (352 mg). MS (ISP) 557 [(M+H)1. Example M38 l5-Methoxy-2-[3-oxo-3-(3-pyridin-2"yl-phenyl)-propionv1aminn1-4-trifluoromethyl phenyll-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-5-methoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J7) (230 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedtire M. Obtained as an off-white solid (240 mg). MS (ISN) 528 [(M-H)']; mp 164 °C Example M39 {5-Ethoxy-2-[3-oxo-3-f3-pyridin-2-yl-phenyl)-propionylamino1-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phen)d)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yi-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (234 mg). MS (ISN) 542 [(M-H)-]; mp 128-144 °C f2"r3-Oxo-3-(3*pyridin-2"yl-phenylVprnpinTiylaTninn]-5-(2,^^ trifluoromethyl'phen^l-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifltioro-ethoxy)-4-trifluorometii)d-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propiomc add tert-butyl ester (Example K3) (223 mg> 0.75 mmol) according to the general procedure M. Obtained as an oflf-white solid (199 mg). MS (ISN) 596 [(M-H)-]; mp 68-71 °C ^4-CMoro-5-methyl-2-f3-oxo-3-f3-pyridin-2-yl-phenyl)-propionylanuno1-phenylK carbamic add tert-butyl ester The tide compound was prq)ared from (2-aniino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (320 mg). MS (ISN) 478.2 [(M-H)-] and 480 [(M+2-H)']; mp 135-137 °C. Example M42 l5"Methyl"2-r3-oxo-3-f3-pyridin-2-yi-phenyl)-propionylarnino1-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was obtained from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M as a white foam (283 mg). MS (ISN) 512,2 [(M-H)-]; mp 76-77 °C. Example M43 (5-Dimethvlamino*2--f 3- FS-f 2,6-Himetliyl-pyridin-^-yl)-phenvi1 -3-oxo-propionvlamino}-4-lTifluoromethvl-phenyl)-c^^^ addtert-butyl ester The title compound was prepared from (2-amino-5-dimelliylainino-4-trifluoromethyl-phenyl)-carbamic addtert-butyl ester (Example Jl) (239 mg> 0.75 mmol) and 3-[3-(2,6-dimethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K8) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous brown substance (201 mg). MS (ISN) 569.1 [(M-H)-]. Example M44 l4-Chloro-5-methyl-2-r3-oxO"3-f3-pyridazin-4-Ad-phenylVpropionylaTninn1-phenvU-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) and 3-oxo-3-(3-pyridazin-4-yl-phenyl)-propionic add tert-butyl ester (Example K9) according to the general procedure M. Obtained as a light yellow solid (184 mg). MS (ISN) 479 [(M-H)-] and481 [(M+2-H)']. Example M45 (5-Methvl-2-[3-oxo*3-f3-pyridazin-4-yl-phenyl-propionylamino1-4-trifluoromethvl-phenyl)-carbamic add tert-butyl ester The title compound was obtained from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) and 3-oxo-3-(3-pyrida2in-4-yl-phenyl)-propionic add tert-butyl ester (Example K9) according to the general procedure M as a light yellow solid (175 mg). MS (ISN) 513 [(M-H)-]. Example M46 (2-13- [3-f 6-Metfaox7-pyridin-3-yl-phenylnyl] -3-oxo-propionylamino^-4-trijSuoromethvi" phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (249 mg> 0.9 mmol) and 3-[3-(6-methoxy-pyridm-3-yl)-phenyl] -3-oxo-propionic add tert-butyl ester (Example KIO) (350 mg, 1.07 mmol) according to the general procedure M. Obtained as an orange foam (284 mg). MS(ISN)528[(M-H)-]. Example M47 f4-CMoro-2-l3-F3"f6-methoxy-pyridin-3-yD-phenyl]-3-oxo-propionvlaminol"phenyl)-carbamic add tert-butyl ester The title compound was obtained from (2-amino-4-d3loro-phenyl)-carbamic add tert-butyl ester (Example J4) (196 mg, 0.81 mmol) and 3-[3-(6-methoxy-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example KIO) (312 mg, 0.95 mmol) according to the general procedure M as a brown oil (285 mg). MS (ISN) 494.1 [(M-H)-] and 496 [(M+2-H)"]. Example M48 (4-Chloro-5-fluoro-2-f3-oxo-3-(3-pyridin-2-yl--phenyl)-propionvlamino1-phenyll" carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-fluoro-phenyl)-carbamic add tert-butyl ester (Example J5) (205 mg, 0.79 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (302 mg, 0.97 mmol) according to the general procedure M. Obteined as a pink foam (340 mg). MS (ISN) 482.2 [(M-H)-] and 484 [(M+2-H)"]. Example M49 f2'-Fluoro-3-r3-oxo-3-[3-pyridin-2-yl-phenyD-propionvlamino1-biphenyl-4-yll-carbamic add tert-butyl ester The title compound was prepared from (3-amino-2'-fiuoro-biphenyl-4-yl)-carbamic add tert-butyl ester [CAS-No. 335255-65-7] (227 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2- yl-phenyl)-propionic add tert-butyl ester (Bcample K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as alight yellow viscous oil (356 mg). MS(ISN)524[(M-Hr]. Example M50 ^2-[3-Oxo-3-(3-pyridin-2-yl-phenyD-propionylamino1-4"pyrrol-l-yl-phenyU-CT^ acid tert-butyl ester The title compound was obtained from (2-amino-4-pyrrol-l-yl-phenyl)-carbamic add tert-butyl ester (Example Jll) (205 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-)d-phenyl)-propionic add tert-butyl ester (l^ample K3) (223 mg, 0.75 Eomol) according to the general procedure M as a yellow solid (300 mg). MS(ISN)495[(M-H)-]. Example M51 l5-Methoxy-2-f3"OXo-3-(-^-pyridiTi-3-yl-phenyl)-propionylaininol-phenyl>-carbamic add tert-butyl ester The tide compound was prepared from (2-Amino-5-methoxy-phenyl)-carbamic add tert-butyl ester (Example J12) (179 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-'5i-phenyl)-propionic add tert-butjd ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light brown foam (256 mg). MS (ISN) 460.3 [(M-H)-]. Example M52 f 2- r3-Oxo-3-f 3-pyridin-2-yl-phenyD-propionylaminol -5-f 2.2.2-trifluoro-ethoxy)-phenyll -carbamic add tert-butyl ester The title compound was obtained from [2-amino-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester (Example J13) (230 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)*propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M as an orange oil (388 mg). MS (ISN) 528 [(M-H)-]. Example M53 f2"r3-Qxo-3-f3-pyridin-3-yl-phenyD-propion^ammo1-5-(2.2^-tT^ phenyl]-carbamic add tert-butvi ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-phenyl]-* carbamic add tert-butyl ester (Example J13) (230 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-bntyl ester (Example Kl) (223 mg, 0,75 romol) according to the general procedure M. Obtained as a light brown solid (362 mg), MS(ISN)528[(M-Hr]. Example M54 [2- r3-Oxo-3-f 3-pyridin-4-yl-phenylVpropionylamino] -5"(2,2 Jl-trifluoro-ethoxy)-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester (Example J13) (230 mg, 0,75 namol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (&cample K2) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a li^t brown solid (258 mg). MS (ISN) 528 [(M-H)-]. Example M55 (5-ethoxy-2-l3-[3-(2-metfayl-pyridin-4-yl)-phenyl1-3"OXo-propionvlaimno}-phenyD-carbamic add tert-butyl ester The title compound was obtained from (2-amino-5-ethoxy-phenyl)-carbamic add tert-butyl ester (Example J14) (189 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (234 mg, 0,75 mmol) according to the general procedure M. Obtained as a H^t yellow amorphous substance (247 mg). MS (ISN) 488 [(M-H)-]. Example MSfi (5-Etfaoxv-2-l3-f3-(2-methyl-pyridin-4-yl)-phenyll*3-oxo-propion^ carbamic add tert-butyl ester The title compound was obtained from (2-amino-5-ethoxy-phenyl)-carbamic acid tert-butyl ester (Example J14) (189 mg, 0.75 mmol) and 3-[3-(4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M as a light ydlow amorphous substance (247 mg). MS(ISN)488[(M-H)-]. Fyample MS7 (5-Ethoxy-2-{3-[3-(2*methvl-pyridin-4-yl)-phenyll-3-oxo-propionylainino}-4-trifluoromefliyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-etiboxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (358 mg). MS (ISN) 556 [(M-H)-]; mp 135-149 °C. Example M58 l5-fCydopropyl-methyl-amino)-2-[3-oxo-3-f3-pyridin-3-yl-phenyD-propionvlaniino1-4-trifluoromethvi-phen)dl-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(cydopropyi-methyl-amino)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J15) (259 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (393 mg), ; MS (ISN) 567,1 [(M-H)-]- Example M59 l5-Isobutylamino-2- [3-oxo-3-(3-pyridBbni-4-yl-phenylVpropionylamino] -4-Irifluoromeliiyl'phenyll-carbamic acid tert-bulyl ester The title compound was prepared from [2-ainino-5-(isobutyl-amino)-4-trifluorometh)d-phenylj-carbamic.add tert-butyl ester (Example J18) (347 mg, 1,0 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow solid (570 mg, 100%), MS(ISP)57L2[(M+Hr]- Example M60 {5-Methyl-2- f 3-oxo-3-(3-pyridin-4-vi-phenyl)-propionyLariiinoT -4-trifluoromethyl-phenvU-carbamic add tert-butyl ester The title compound was obtained from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (290 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-4"yi-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg, LO mmol) according to the general procedure M as a white solid (340 mg, 66%). MS (ISP) 512.2 [(M-H)-]; mp 173 °C Example M61 l4-Methvl-2- [3-oxo-3-(3-pyridin-4-yl-phenylVpropinnYlaTnino1 -5-trifluoromethyl-phenyll-carbamic add tert-butvi ester The title compound was prepared from (2-aniino-4-meth)d-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J23) (290 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg, 1.0 mmol) according to the general procedure M. Obtained as a white solid (276 mg, 54%). MS (ISP) 512.2 [(M-H)-]; mp 158°C Example M62 U-CHorO'5-methyl-2-f3"Oxo-3-(3-pyridin-4-yl-phenylVpro^^^ rarhamir acid tert-butyl ester The title compound was obtained from (2-amino-4-chloro-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (257 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg> 1.0 mmol) according to the general procedure M as a light yellow foam (370 mg, 77%). MS (ISP) 478.2 [(M-H)-]. Example M63 l5-CHoro-4-methyl-2-f3-oxo-3-f3-pyridin-4-yl-phenylVpropionylaiiiino1-phenyll-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-methyl-phenyl)-carbamic add tert-butyl ester (Example J21) (257 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg, 1.0 mmol) according to the general procedure M. Obtained as an off-white foam (370 mg, 77%). MS (ISP) 478.2 [(M-H)-]. Example M64 l5-Chloro-2-f3-oxo-3-f3-pyridin-4-yl-phenyD-propionyiaminol-4-trifluoromethvl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-diloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (311 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow foam (400 mg, 75%). MS (ISP) 534.3 [(M+H)*"]. Example M65 (2'-Huoro-3-l3-f3-(2-methyl-pyridin-4-yl)-phenyl1-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic add tert-butyl ester The title compound was prepared from (3-amino-2'-fluoro-biphenyl-4-yl)-carbamic add tert-butyl ester [CAS 335255-65-7] (302 mg, 1-0 mmol) and 3-[3-(2-methyl-pyridin-4- yl)-phenyl]-3-oxo-propionic add tert-butyl ester (j&cample K12) (311 mg, 1,0 mmol) according to the general procedure M. Obtained as an ofif-white foam (480 mg, 89%). MS (ISP) 540.3 [(M+H)+]. fccample M66 (4-CMoro-5-mediyl-2-l3-f3-(2-methyl-pyridin*4-yl)-phenyl1-3-oxo-propionvlanm phenyP-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (257 mg, 1.0 mmol) and 3-[3-(2-methyl-pyTidin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M. Obtained as an off-white foam (470 mg, 95%). MS (ISP) 492.11(M-H)-], Example M67 (4-Chloro-2-l3-f3-(2-methyl-pyridin-4-yl)-phenyl1-3-oxo-propionyianiinn}-pberiy1)-carbamic add tert-butvi ester The title compound was obtained from (2-amino-4-diloro-phenyl)-carbamic add tert-butyl ester (Example J4) (243 mg, 1,0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M as a light brown foam (410 mg, 85%). MS (ISP) 478.2 [(M-H)']. Example M68 (5-Methyl-2-l3-r3-(2-me&vl-pyridin-4-yl)-phenyll-3-oxo-propionylaminn}-4-trifluoromethvl-phen^d)-carbamic add tert-but\i ester The title compound was prepared from (2-araino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (290 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M. Obtained as a white foam (430 mg, 82%), MS (ISP) 526.0 [(M-H)-]. Example M69 (2-l3-[3-f2"methyl-pyridin-4-yl)-phenyl1-3-oxo-propion^ainm phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (276 mg, 1.0 mutnol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1,0 mmol) according to the general procedure M. Obtained as a light brown foam (420 mg, 82%), MS (ISP) 5122 [(M-H)-]. Example M70 f4-Methvl-2-l3-r3-(2-methyl-pyridin-4-yl)-phenyl1-3-oxo-propionylaniinol-5-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J23) (290 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow foam (330 mg, 63%). MS (ISP) 526.1 [(M-H)-], Example M71 (5-Dimethylamino-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionvlaminol-4-trifluoromethvl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-dimethylainino-4-tri£luorome1hyl-phenyl)-carbamic add tert-butyl ester (Example Jl) (319 mg, 1-0 mmol) and 3- [3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1-0 nrniol) according to the general procedure M. Obtained as a pale pink foam (460 mg, 83%). MS (ISP) 555.1 [(M-H)']. E3cample M72 (4-CHoTO-5-isobuti?1arnirin-2-l3-[3-(2"metfavl-pvriHiri*4-Y^ propionylaminol-phenyl)-carbamic acid tert-butvi ester The title compound was prepared from (2-amino-4-cUoro-5-isobutylarciino-phenyl)-carbamic add tert-butyl ester (Example J16) (314 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-)d)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, LO mmol) according to the general procedure M. Obtained as a yellow foam (480 mg, 87%). MS (ISP) 549.1 l(M-H)-]. Example M73 f5-(Methyl-propy1-aminn)-2-l3-[3-(2-metfavl-pyridin-4-vD-phenyl1*3-oxo-pTnpinnylaTninn|-4-trifluoromethyl-phenyl')-carbamic add tert-butyl ester The title compound was obtained from [2-amino-5-(metfiyl-propyi-amino)-4-trifluoromethyl-phenyl]-carbamic add tCTt-butyl ester (Scample J17) (347 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M as a light red foam (470 mg, 80%), MS (ISP) 583.1 l(M-H)-]. Example M74 {5-f Methvl-propyl-amino V2- f 3-oxo-3-f 3-pyridin-4-yl-phenyl)-propionylamino1 -4-trifluoromethyl-phenvil-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(meth)d-propyl-amino)-4-trifLuoromethyl-phenylJ-carbamic add tert-butyl ester (Example J17) (347 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg, 1.0 mmol) according to the general procedure M. Obtained as a ligbt red foam (550 mg, 96%). MS (ISP) 569.11(M-H)-]. Example M75 f 5-Chloro-2-f 3- r3-(2-methyl-pyridin-4-yl)-phenyl1 -3-oxo-propionylaTr>inn}-4^ Irifluoromeflivl-phenyl)-carbamic add tert-butyl ester The title compound was obtained from (2-amino-5-cMoro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J19) (311 mg, 1,0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionicacidtert-biityl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M as an ofif-white solid (345 mg, 63%). MS (ISP) 546,0 [(M-H)']; mp 177°C Example M76 f4-Huoro-2"l3-[3-(2-metfaAd-pyridin-4-yl)-phenyll"3-oxo-propion-\daminol-phenyl')-carbamic add tert-butyl ester The compound was prepared from (2-amino-4-fluoro-phenyl)-carbamic add tert-but)d ester (Example J2) (226 mg, LO romol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl3-3-oxo-propionic add tert-butyl ester (Ifeample K12) (311 mg, 1,0 mmol) according to the general procedure M. Obtained as an off-white foam (390 mg, 84%). MS (ISP) 462,2 [(M-H)-]. Example M77 f5-CMoro-4-methyl-2-f3-[3-(2-metfayl-pyridin-4-yl)-phenyl1-3-oxo-propion;^aminol-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-methyl-phenyl)-carbamic add tert-butyl ester (Example J21) (257 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-}d)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 nrniol) according to the general procedure M. Obtained as a white solid (372 mg, 75%). MS (ISP) 492.2 [(M-H)1; mp 171 °C, Example M78 {5-Dimethviamino-2-f3-oxo-3-f3-pyrimidin-5-vl-phenyl-propionylamino1-4-trifluoromethyl-phenyU-carbamic acid tert-butyl ester The title compound was obtained from (2-amino-5-dimethylamino-4-trifluorometh)i-phenyl)-carbainic add tert-butyl ester (Example Jl) (319 mg, 1.0 mmol) and 3-oxo-3-(3- pyriiiudin-5-yl-phenyl)-propiomc add tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M as an off-white solid (370 mg, 68%). MS (ISP) 542,1 [(M-H)1; mp 144 °C. Example M79 {4-Chloro-5"methyl-2- [3-oxo-3- ('3-pyrazin-2-yl-phenyl')-propion^^damino^ -phenyl}* carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (257 mg, 1.0 mmol) and 3-oxo-3-(3-pyrazin-2-y[-phenyl)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a white foam (320 mg, 67%). MS (ISP) 479.2 [(M-H)1. Example M80 l5-Methyl-2-r3-oxo-3-(3-pyra2in-2-yl-phenylVpropinnYlaTTiino1-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phen)d)-carbamic add tert-butyl ester (Example J20) (290 mg, 1.0 mmol) and 3-oxo-3-(3-pyra2in-2-yl-phenyl)-propionic add tert-butyl ester (Sample K14) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a white foam (350 mg, 68%). MS (ISP) 513.1 [(M-H)1. Example M81 12- f 3-Oxo-3-(3-pyra2in-2-yl-phenylVpropionylamino1 -4-trifluoromethvl-phenylK carbamic add tert-butyl ester The title compound was obtained from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (276 mg, 1.0 namol) and 3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M as a light brown foam (340 mg, 68%). MS (ISP) 499.1 [(M-H)1. Example MS? J5-Dimethviammo-2- fS-oxo-S-f 3-pyra2in-2-yl-phenyD-propionylamino1 -4-Irifluorometfavl'phenyU-carbarnic add tert-butyl ester The title compound was prepared from (2-amino-5-dimethylammo-4-trifluoromethyl-phenyl)-carbamic add tert-butj^ ester (Example Jl) (319 mg, 1.0 mmol) and 3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M, Obtained as a light brown foam (370 mg, 68%). MS (ISP) 542.1 [(M-H)-]. ^ Example M83 {5-Chloro-2"f3-oxo-3-f3-pvrazin-2"yl-phenylVpropionylaminol-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was obtained from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic acidtert-butyl ester (Example J19) (311 mg, 1.0 mmol) and 3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic addtert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as an ofif-white foam (180 mg, 34%). MS (ISP) 533.1 [(M-H)-]. Example M84 U'-Fluoro-3-[3-oxO"3-(3-pyrazin-2-yl-phenylVpropionylaminol-biphenyl-4-vi}-carbamic add tert-butyl ester The title compound was prepared from (3-amino-2'-fiuoro-biphenyl-4-yl)-carbamic add tert-butyl ester [CAS 335255-65-7] (302 mg, LO mmol) and 3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M, Obtained as an off-white foam (350 mg, 66%). MS (ISP) 525.1 [(M-H)-]. Example M85 l4-Methyl-2-r3-oxo-3-(3-pvra2in-2-yl-phenylVpropionylamino]-5-trifluoromethyl-phenvU-carbamic add tert-butvi ester The title compound was prepared from (2-amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J23) (290 mg, 1.0 mmol) and 3-oxo-3-(3- pyrazin-2-yl-phenyl)-propionic add tert-butyl ester (Esample K14) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a white foam (290 mg, 56%). MS (ISP) 513,2 [(M-H)-]. Example M86 {4-CblorO'2-F3-oxO"3-f3-pyrimTdin-5-vl-phenylVpropinnYlammn]-pbeny^ acid tert-butyl ester The title compound was prepared from (2-amino-4-chloro-phen)d)-carbainic add tert-butyl ester (Example J4) (243 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic add tCTt-butyl ester (Escample K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown solid (350 mg, 75%). MS (ISP) 479.2 [(M-H)-]; mp 169 °C Example M87 (5-Chloro-2- r3-oxo-3-f 3-pvrimidin-5-yl-phenyl')-propionylamino1 -4-trifluoromethyl" phenvU-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (311 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic add tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a yellow oil (420 mg, 79%). MS (ISP) 533.1 [(M-H)1. Example M88 (4-CMoro-5-isobutylaniino-2- [3-oxo-3-(3-pyrimidin-5-yl-phenylVpropionylaniinol -phenyll-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-4-chloro-5-isobutylamino-phenyl)-carbanaic add tert-butyl ester (Example J16) (235 mg, 0.75 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic add tert-butyl ester (Example K13) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white foam (260 mg, 64%). MS (ISP) 536.2 [(M-H)-], Example M89 ^5-Metfayl-2-r3"OXO-3-f3-pYrimiHin-5-Yl-phenylVpropionvlaminoV phenyll-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-meth)d-4-triflTioromethyi-phenyl)-carbamic add tert-butyl ester (Example J20) (290 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic add tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as an off-white foam (290 mg, 56%). MS (ISP) 515.3 [(M+H)+]. Example M90 {5-(Methyl-propyi-aniino>-2-r3-oxo-3-f3-pyriTTiidin-5-yi-phen\dVpropionyiaiiim trifluoromethyl-phenyU-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(methyl-propyl-amino)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J17) (347 mg, 1.0 mmol) and 3-oxo-3-(3-pyriinidin-5-yl-phen)d)-propionic add tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a red oil (370mg,65%). MS (ISP) 570.2 [(M-H)-]. Example M91 (4-CMoro-2-l3-[3-(2-methvl-pyridin-4-yl)-phenyl1-3-oxo-propionvlaminol-5-trifluoromethvl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-trifiuoromethyl-phenyl)-carbamic add tert-butyl ester (Example J24) (466 mg, 1.5 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (467 mg, 1.5 mmol) according to the general procedure M. Obtained as an orange oil (360 mg, 44%). MS (ISP) 546.1 [(M-H)-]. Example M92 ^4-CHoro-2-f3-oxo-3-f3-pyridin"4"yl-phenyl)-propionvlarnirin]-5-tri^ phenvB-carbamic add tert-butyl ester The title compound was obtained from (2-amino-4-chloro-5-trifluoromethyl-phen)4)-carbamic add tert-butjrl ester (Example J24) (466 mg, 1.5 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (446 mg, 1.5 mmol) according to the general procedure M as a li^t yellow oil (440 mg, 55%), MS (ISP) 532.1 [(M-H)-]. Example M93 (5-(Methyl*propvl-ainino)-2-[3'OXo-3-f3-pyrazin-2-yl-phenylVpropioTiylamin trifluoromethyl-phenylKcarbamic add tert-butyl ester The title compound was prq)ared from [2-amino-5-(methyl-propyl-amino)-4-trifluoromethyl-phenylj-carbaimc add tert-butyl ester (Example J17) (347 mg, 1.0 mmol) and3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to tihie general procedure M. Obtained as a light red foam (350 mg, 61%). MS (ISP) 570.1 [(M-H)']. Example M94 l5-CHoro-4-methvl-2-f3*oxo-3-f3-pvra2iQ-2-yl-phenyl)-propionAdamino1-phenyU-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-methyl-phenyl)-carbamic add tert-butyl ester (Example J21) (257 mg, 1.0 mmol) and 3-oxo-3-(3-pyrazin-2-yl-phenyl)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a white solid (390 mg, 81%). MS (ISP) 479,2 [(M-H)-]. Example M95 U"CHoro-5-methyl-2-f3-oxo-3-f3-pyrimidin-5"yl-phenyl)-propionylai^ carbamic acid tert-butyl ester The title compound was obtained from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (257 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-plienyi)-propiomc add tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M as a light yellow oil (440 mg, 91%). MS (ISP) 4792 [(M-H)-]. Example M96 (2'-Fluoro-3- f 3-oxo-3-f 3-pvrimidin-5-yl-phenyl)-propionylamino] -biphenid-4-yll-carbamic add tert-but^ ester The title compound was prepared from (3-amino-2*-fluoro-biphenyl-4-yl)-carbamic add tert-butyl ester [CAS 335255-65-7] (302 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic add tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow oil (420 mg, 80%). MS (ISP) 525.0 [(M-H)-], Example M97 l4-Methvl-2-[3-oxo-3-f3-pvrmudin-5-vl-phenyl)-propionvlainino1-5-trifluoromethv^ phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J23) (290 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic add tert-butyl ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow oil (430 mg, 84%). MS (ISP) 513.2 [(M-H)-], Example M98 l4-CMoro-2"f3-oxo-3-[3-pYridin-?.-vI-phenyl-propion^amino1-5-lTiflu^ phenyl)-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-4-diloro-5-trifluoromethyl-phenyl)-carbamic add tert-butjd ester (Example J24) (466 mg, 1.5 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (446 mg, 1.5 mmol) according to the general procedure M. Obtained as an orange oil (310 mg, 39%). MS (ISP) 532.0 I(M-H)-]. Example M99 (2-13- r3-f 2'Methyl>pyridin-4-yl')-phenyl] -3"OXo-propion^amino}-4-pyrrol-l-'\d-phen^)-carbamic add tert-butyl ester The title compound was obtained from (2-amino-4-pyrrol-l-yl-phenyl)-carbamic add tert-butyl ester (Example Jll) (273 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedmre M as a yellow oil (490 mg, 96%). MS (ISN) 509.3 [(M-H)-]. Example M100 \2- [3-Oxo-3-f 3-pvrazin-2-yi-phenyD-propionvlamino1 -4-pyrrol-l -yl-phenyll-carbaroic add tert-butyl ester The title compound was obtained from (2-amino-4-pyrrol-l-yl-phenyl)-carbamic add tert-butyl ester (Example Jll) (273 mg, 1.0 mmol) and 3-oxo-3-(3-pyra2in-2-yl-phen)d)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to "die general procedure M as a light brown solid (370 mg, 74%). MS (ISN) 496.1 [(M-H)-]; mp 143°C. Example M101 ^4-Chloro-2- f 3-oxo-3- f 3-pyra2m-2-yl-phenylVpropionylan3dnol -5-trifluoromethvl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J24) (310 mg, 1.0 mmol) and 3-oxo-3-(3- pyra2in-2-yi-phenyl)-propionic add tert-butyl ester (Example K14) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a yellow oil (280 mg, 52%). MS (ISP) 533.0 [(M-H)-]. Example M102 l4-CMoro-2-f3-oxo-3-(3-pyrimidin-5-yl-phenyD-prnpTonYlaTriirin]-5-trifluo phenyU-cafbamic acidtert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-trifiuoromethyl-phenyl)-carbamic add tert-butyl ester (Example J24) (311 mg, 1.0 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic add tert-butjd ester (Example K13) (298 mg, 1.0 mmol) according to the general procedure M. Obtained as a yellow oil (320 mg, 60%). MS (ISP) 533.1 [(M-H)-]. Example M103 [2-f3-Oxo-3-(3-pyrazin-2-vi-phenylVpropinTiv1ammn1-5-(2,2,2-trifluoro-ethoxyV4-trifluoromethyl-pheDyi]-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenylj-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-oxo-3-(3-pyra2m-2-yl-phenyl)"propionic add tert-butyl ester (Example K14) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as an orange foam (370 mg, 82%). MS (ISP) 596.9 I(M-H)-]. Example M104 U-Chloro-2-[3-oxo-3-(3-pyridiTi-3-vl-phenylVpropionylamino1-5-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Ifeample J24) (230 mg, 0.74 mmol) and 3-oxo-3-(3-pyridin-3-yi-phenyl)-propionic add tert-butyl ester (Example Kl) (220 mg, 0.74 romol) according to the general procedure M. Obtained as a light yellow solid (260 mg, 66%). MS (ISP) 532.1 [(M-H)1; mp 158^0, [2--f3-r3-(2-Metfayl-pyridin-4-yl-phenyl1-3-oxO"propiony eliioxy>-4-lTifluoromethyl-pheny[1-carbamic add tert-butyl ester The title compound was prepared from [2-amiiio-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenylj-carbamic add tert-butyl ester (Example J6) (374 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-but)d ester (Example K12) (311 mg, 1.0 mmol) according to ibe general procedure M. Obtained as an orange oil (450 mg, 74%). MS (ISP) 609.9 [(M-H)']. Example M106 f4-Chloro-2-l3-f3-r:2,fi-dimethvi-pyridin>4-vD-phenyl1-5-metfavi-3-oxo-propionyiaminol-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (174 mg, 0.68 mmol) and 3-[3-(2,6-dime&yl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (220 mg, 0.68 mmol) according to the general procedure M. Obtained as a white foam (290 mg, 84%). MS(ISP)506^[(M-H)-]. Example M107 f4-Chloro-2-{3-[3-(2^fi-dimethvl-pyridin-4-yl-phenylV3-oxo-propiQnylamino}-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-phenyl)-carbamic add tert-butyl ester (Example J4) (243 mg, 1,0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phen)i]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown foam (240 mg, 49%). MS (ISP) 492.1 [(M^H)"]. Example M108 f2-{3"[3-f2,6-Dimethvl-pyridin-4-yl)-phenyll-5-methyl-3-oxo-propiQny^ trifluoromethyl'phenylVcarbamic add tert-butyl ester The title compound was prepared from (2-amdno-5-methyl-4-trifluoromethyl-ph€nyl)-carbamic add tert-butyl ester (Example J20) (196 mg> 0.68 mmol) and 3-[3-(2,6-dimeth)d-pyTidin-4-}d)-phen)d]-3-oxo-propionic add tert-butyl ester (Example K15) (220 mgj 0.68 mmol) according to the general procedure M. Obtained as an off-white foam (300 mg, 82%). MS (ISP) 540,2 [(M-H)-]. Example M109 (2-l3-f3-(2.6-Dimethyl-pyridin-4-yl)-phenyl1-3-oxo-propionylamino)-4-trifluoromethyl-phenyl)-r-flrbflTnrc add tert-butyl ester The title compound was prepared from (2-anmio-4-trifluoromethyl-phen)d)-carbamic add tert-butyl ester (Example J3) (187 mg, 0.68 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (220 mg, 0.68 mmol) according to the general procedure M. Obtained as an off-white foam (270 mg, 76%). MS (ISP) 526.0 [(M-H)-]. Example MHO (2-l3-f3-(2.6-Dimethyl-pyridin-4-yl-phenyll-4-methyl-3-oxo-propionylaminol-5-trifluoromethvl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J23) (196 mg, 0.68 rranol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (220 mg, 0.68 mmol) according to the general procedure M. Obtained as a lightydlow foam (300 mg, 82%), MS (ISP) 540.2 [(M-H)-]. (5-CHoro-2-l3-r3-f2>6"dimet1iyl^pyridm-4-yl)-phenyl1-3-oxo-propiony trifluoromethvl-phenyl-carbaTnic add tert-butvi ester The title compound was prepared from (2-ai}iino-5"cMoro-4-trifluoromethyl-phenyl)-carbamic add tert-butjd ester (Example J19) (210 mg, 0.68 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phen}d]-3-oxo-propionic add tert-butyl ester (Example K15) (220 mg, 0.68 mmol) according to the general procedure M. Obtained as a white foam (260 mg, 68%), MS(ISP)560.1[(M-H)-]. Example Ml 12 f5-Chloro-2-l3-f3-(2,6-dimetfavi-pyridin-4-vD-phenyll-4-methvl-3-oxo-propionyiaminol-phenyP-carbamic add tert-butd ester The title compound was prepared from (2-aniino-5-cUoro-4-methyl-phenyl)-carbanuc add tert-butyl ester (Example J21) (174 mg, 0.68 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-)d)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (220 mg, 0.68 ixmoiol) according to the general procedure M. Obtained as a white foam (290 mg, 84%). MS (ISP) 506.2 [(M-H)']. Example Ml 13 f4"CMorO"2-l3"r3-(2,6-dimethyl-pyridin-4-yl-phenAd]-3-oxo-propionvlaminol-5-trifluoromethvl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-chlorO"5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J24) (311 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow oil (356 m%, 63%). MS (ISP) 560.1 [(M"H)-]. Example Ml 14 r2-^3"[3-(2ifi-nimetTivi-pyridin-4-yl')-phenyl1*3-oxo-propionvlamm lTifluoro-et3ioxyV4-trifluoromethyl-phen'\d1-carbainic acid tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-txifluoromethyl-phenyl]-carbamic acidtert-butyl ester (Example J6) (374 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown foam (510 mg, 82%). MS (ISP) 624.0 [(M-H)-]. Example M115 5-Ethoxy-f2-l3-r3*('2.6-dime&y1-pyridin-4-yl)-phenvi1-3-oxo-propionyiaminol-4-trifluoromethyl-phenyn-carbamic acidtert-butyl ester The title compound was prepared from [2-amino-5-ethoxy-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J8) (320 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-)d)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow foam (530 mg, 93%). MS (ISP) 570.1 [(M-H)-]. Example Ml 16 (4-CMorO'5-methyl-2-l3-f3-(6-methyl-pyrazin-2-"yD-phenyl1-3-oxo--propionvlamino)-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (257 mg, 1.0 mmol) and 3-[3-(6-methyl-pyra2in-2-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K16) (312 mg, 1.0 mmol) according to the general procedure M. Obtained as a h^t brown foam (470 mg, 95%). MS (ISP) 493.1 [(M-H)-], Example Ml 17 | r5-Methvl-2-^3-r3-(6-medivl-pyrazin-2-vlVphenyl1-3-oxo-propionvlanm trifluoromethyl-phenyl)-carhamic add tert-butyl ester The title compound was prepared from (2-ammo-5-methyl-4-trifluoromethyi-phenyl)" carbamic acid tert-butyl ester (Example J20) (290 mg, 1.0 mmol) and 3-[3-(6-methyl-pyra2in-2-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K16) (312 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown foam (460 mg, 87%). MS (ISP) 527.0 [(M-H)']. Example Ml 18 f4-Methyl-2-l3-[3-(6-methyl-pyrazin-2*ylVphenvi1-3-oxo-propionylaminol-5-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-methyl-5-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J23) (290 mg, 1.0 mmol) and 3-[3-(6-methyl-pyrazin-2"yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K16) (312 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown foam (400 mg, 76%). MS (ISP) 527.0 [(M-H)-]. Example Ml 19 r5-CMoro-4-methyl-2-f3-r3-f6-methyl-pyrazin-2-yl)-phenyl1-3-Qxo-prnpinriy1amirin}-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-methyl-phenyl)-carbamic add tert-butyl ester (Example J21) (257 mg, 1.0 mmol) and 3-[3-(6-methyl-pyrazin-2-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K16) (312 mg, 1.0 mmol) according to the general procedure M. Obtained as a li^t brown foam (400 mg, 81%). MS (ISP) 493.1 [(M-H)-]. Example M120 (4-CMoro-2-l3-f3-(2,5-dime&yl-pyridin-4-yl)-phenyl1-5-m pTnpinnylflminol-phenyl)-carhamic add tert-butyl ester The title compound was prepared from (2-ainino-4-cblorO"5"methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(2,5-dimethyl-pyridin-4-yl)"phenyl]-3-oxo-propionic add tert-butyl ester (Example K17) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an ofif-white solid (250 mg, 66%). MS (ISP) 506.2 [(M-H)-];mp 169°C Example M121 (2-{3-[3-f23-Dimethyl-pyridin-4-yl)-phenyl1-5-methyl-3-oxo-propinnylflrninn}-4^ trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-anunO"5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2,5-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K17) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (360 mg, 89%). MS (ISP) 540.2 [(M-H)-]. Example M122 f5-Chloro-2-l3-f3-(2.5-dimethyl-pyridin-4-yl)-phenyl1-3-oxo-propinny1aTTimn}-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (233 mg, 0.75 mmol) and 3-[3-(2,5-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K17) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an ofiF-white foam (240 mg, 57%). MS (ISP) 560.1 [(M-H)']. Example M123 r2-l3-r3-(2.5"Dimethvl-pyridin-4-yl)-phenyl1-3-oxo-propionvlair^ 1xifluoro-el3ioxv)-4-tTijSuoromethyl-phenyl1-carbaim acidtert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-tiifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(2,5-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K17) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an oflf-white solid (300 mg, 64%), MS (ISP) 624.0 [(M-H)']; mp 178 °C Example MI24 5-Elhoxy- [2-13- f 3-(2.5-dTTnettiy1-pyrif1in-4-yl)-phenyl1 ■3-oxo-propionyianainol-4-trifluoromethvi-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-ethoxy-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Esampie J8) (240 mg, 0.75 mmol) and 3-[3-(2,5-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K17) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (250 mg, 58%). MS (ISP) 570.1 [(M-H)-]. Example M125 (4-Chloro-2-{3-[3-(23-dimethvl-pyridin-4-yl)-phenyl1-5-metfavl-3-oxo-propionylaminol-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-diloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(2,3-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K18) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an orange foam (280 mg, 73%). MS (ISP) 506.2 [(M-H)-]. Example M126 f2-l3-[3-(23-Dime&vl-pyridin-4-yl)-phenyl1-5-methyl-3-oxo-propionylamino}-4 trifluoromethvl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(23-dimethyl-pyridin-4-)d)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K18) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow oil (320 mg, 79%). MS (ISP) 540.2 [(M-H)-], Example M127 (2-{3-[3-f2.3-Dimethyl-pyridin-4-yl-phenyl1-3-oxo-propionvlaminol-4-trifluorometfayl-phenyl)-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(2,3-dimethyl-pyTidin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K18) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow oil (310 mg, 78%). MS (ISP) 526.1 [(M-H)-]. Example M128 (5-Chloro-2-l3-[3-(23-dimethyl-pyridin-4-yl)-phenyll-3-oxo-propionylaminol-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (233 mg, 0.75 mmol) and 3-[3-(2,3-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K18) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow oil (340 mg, 81%). MS (ISP) 560.2 [(M-H)-]. Example M129 [2-{3-[3-(2,3-Dimethyl-pyridin-4-yl)-phenyl-3-oxo-propionylamino}-5-(2,2,2 txifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethox7)-4-trifluoromethyl-phenylj-carbamic acidtert-butyl ester (Esample J6) (281 mg, 0.75 mmol) and 3-[3-(2,3-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butjd ester (Example K18) (244 mg, 0.75 mmol) according to tibie general procedmre M. Obtained as an orange foam (330 mg, 70%). MS (ISP) 624.2 [(M-H)-]. Example M130 5-Ethoxy-f2"{3-[3-(2,3-dimelhyl-pyridin-4"Vl)-phenyl1-3-oxo-propionylanu trifluoromethyl-phenyll-carbamic acidtert-butyl ester The title compound was prepared from [2-amino-5-ethoxy-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(2,3-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K18) (244 mg, 0,75 mmol) according to the general procedure M. Obtained as a light yellow oil (350 mg, 82%). MS (ISP) 570.3 [(M-H)-]. Scample M131 f4-CMoro-2-{3-[3-(5-ethyl-2-metfavl-pyridin-4--d)-phenyl1-5-metfavl-3-oxo-propionvlaminol-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(5-ethyl-2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K19) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (330 mg, 84%). MS (ISP) 520.2 [(M-H)-]; mp 172 °C Example M132 f2-{3-[3-(5-ethyl"2-metfavI-pyridin-4-yl)-phenyll-5-met^ trifluoromethyl-phenyl)-cafbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(5-ethyl-2-methyl-pyridin-4-yl)-plienyi]-3-oxo-propionic add tert-butyl ester (Example K19) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (300 mg, 72%). MS (ISP) 554.3 [(M-H)-]; mp 173 °C Example M133 (2-{3-[3-f5-Ethyl-2-methvl-pyridin-4-yl)-phenyl]-3-oxo-propionyiaminol-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(5-ethyl-2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K19) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as a light brown solid (260 mg, 64%). MS (ISP) 540.3 [(M-H)-]. Example M134 r2-l3-r3-f5-Etfavl-2-methvl-pyridin-4-yl)-phenyl1-3-oxo-propionvlaminol-5-(2^.2-trifluoro-ethoxyV4-trifluoromethyl-phenyl1-carbamic add tert-butyl ester The title compotmd was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-caxbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(5-ethyl-2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K19) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an oflF-white solid (300 mg, 63%). MS (ISP) 638.2 [(M-H)-]'; mp 183°C 5-Ethoxy"r2-{3-[3-(5-ethyl-2-methyl-pyridin-4-yl)-phenyl1-3-oxo-ppionylamino}-4-txifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-edioxy-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(5-ethyl-2-methyl-pyridin-4-)d)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K19) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an oflF-white solid (310mg,71%). MS (ISP) 584.2 [(M-H)-]; mp 180 °C. Example M136 (4-CMoro-2-{3-[3-(2"edivl-pyridin-4-yl)-phenyl1-5-methyl-3-oxo-propionylaminol-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(2-eth]d-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butjd ester (Example K20) (244 mg, 0.75 mmol) according to the general procedxire M. Obtained as an off-white solid (274 mg, 72%). MS (ISP) 506.2 [(M-H)-]; mp 147 °C. Example M137 (2-^3-f3-(2-ethyl-pyridin-4-yl)-phenyl1-5-methyl-3-oxo-propionylaminol-4-trifluorometfayi-phenyl-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2-ethyl-pyridin-4-yl)-phenyl]"3-oxo-propionic add tert-butyl ester (Example K20) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (295 mg, 73%). MS (ISP) 540.3 [(M-H)-]; mp 158 °C Example M141 5-ethoxy-r2-{3-[3-(2-ethvi-pyridm-4-yll-phenyl1"3" Irifluoromethyl-phenyll-carbamic acid tert-butyl ester The tide compound was prepared from [2-amino-5-ethox7-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (240 mg, 0.75 mmol) and 3-[3-(2-eth)d" pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K20) (244 mg, 0,75 mmol) according to the general procedure M, Obtained as an off-white solid (339 mg, 79%). MS (ISP) 570.3 [(M-H)-]; mp 151°C Example M142 f5-Dimethylamino-2-(3-f3-(6-method-pyridin-2yl)-phenyll-3-oxo-propionylamino-4-trifluoromethyl-phenyl-carbaTnic add tert-butyl ester The tide compound was prepared from (2-amino-5-dimediylamino-4-trifiuoromethyl-phenyl)-carbamic add tert-butyl ester (Eample Jl) (239 mg, 0.75 mmol) and 3-[3-(6-mediyl-pyridiin-2-yi)-phenyl]-3-oxo-propionic add tert-butyl ester (Example Kll) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous light brown substance (339 mg, 67%). MS (ISN) 555 [(M-H)-]. Example M143 (4-CHoro-2-{3-[3-(6-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionylaniinol-5-methyl-phenyP-carbamic add tert-butyl ester The tide compound was prq)ared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (342 mg, 88%). MS (ISN) 518.1 [(M-H)-] and 520 [(M+2-H)-]. Example M144 l5-Etfaoxy-2-r3-oxo-3-f3-pyridin-3"yl-phenylVpropionylaTriinn]-ph tert-butyl ester The title compound was prepared jfrom (2-amino-5-ethox7-phen]d)-carbamic add tert-butyl ester (Example J14) (194 mg, 0.77 imnol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (203 mg, 55%). MS (ISN) 474.2 [(M-H)']. Example M145 ^5-Ethoxy-2- f 3-oxO-3-(3-pyridin-4-yl-phenyl-propionvianiino]-phenyl-Caifaamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-phenyl)-carbamic add tert-butyl ester (Example J14) (193 mg,0.76 mmol) and3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (221 mg, 0.74 mmol) according to the general procedure M. Obtained as an ofif-white foam (227 mg, 65%). MS (ISN) 474.2 [(M-H)']. Example M146 l2-r3-Oxo-3-f3-pyridin-2-yl-phenyl)-propiQnylamino1-4-phen\detfaynyl-phenyll-carbamic add tert-butyl ester The tide compound was prepared from (2-amino-4-phenylethynyl-phenyl)-carbamic add tert-butyl ester {CAS-No, [335255-26-0]} (231 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (313 mg, 44%). MS (ISN) 474.2 [(M-H)']; mp 198 °C. Example M147 l4-f4-Fluoro-phenylethynyD-2-f3-oxo-3-f3-pyridin-2-yl-phenyD-propionylaniino1-phenyl}-carbamic add tert-butyl ester The title compotmd was prepared from [2-amino-4-(4-fluoro-phenylethynyl)-phenyl]-carbamic add tert-butyl ester {CAS-No. [335255-58-0]} (245 mg, 0.75 mmol) and 3-oxo- 3-(3"pyridin-2-^-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0,75 mmol) according to the general procedure M. Obtained as an amorphous li^t brown substance (325 mg, 79%). MS(ISN)548[(M-Hr], Example M148 f2-{3-[3-r6-Cvdopropvl"pyridin-3"VlVphenyl1-3-oxO"propionvlaniinol-5-(2J2,2-trifluoro-ethoxyV4-trifluoromethyl-phenyl1-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2>2-trifluoro-ethox7)-4-trifluoromethyl-phenylj-carbamic acid tert-butjd ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(6-cydopropyi-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0,75 mmol) according to the general procedure M. Obtained as a yeUow foam (344 mg, 72%). MS (ISN) 635.9 [(M-H)-]. Example M149 (2-(3-[3-f6-Cydoprop-pyridin-3-yl)-phenyll-3-oxo-propionvlaniinol-5-methyl-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a ydlow solid (325 mg, 78%). MS (ISN) 552 [(M-H)-]; mp 150-153 °C. Example M15Q (2-{3-[3-f6-Methoxy-pyridin-3-ylVphenyl1-3"OXO-propionylaminol-5-metfayl-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (232 mg, 0,80 mmol) and 3-[3-(6-methoxy-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Scample KIO) (270 mg, 0.82 mmol) according to the general procedure M. Obtained as a yellow foam (287 mg, 66%). MS (ISN) 542.1 [(M-H)-]. Example M151 f 2-13- f 3"(6-Methoxy-pyridm-3-yD-phenyl1 -3-oxo-propion'vlaminol-5-(2^.2-trifluoro-ethoxy)-phenyll-carbaimc add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-plien7l]-carbamic add tert-butyl ester (Example J13) (240 mg, 0.78 mmol) and 3-[3-(6-methoxy-pyridin-3-)i)-phenyl]-3-oxo-propionic add tert-butyl ester (Example KIO) (293 mg, 0.89 mmol) according to the general procedure M. Obtained as a red foam (288 mg, 66%). MS (ISN) 558.1 [(M-H)1. Example M152 [2-{3-f3-f6-Methoxy-pyridin-3-yl-phenylnyl1-3-oxo-propionylaminol-5-(2.2.2-trifluor ethoxy)-4-trifluoromethyl-phenyl1-carbamic add tert-bntyi ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (296 mg, 0.79 mmol) and 3-[3-(6-methoxy-pyridin-3-yi)-phenyl]-3-oxo-propionic add tert-butyl ester (Example KIO) (289 mg, 0.88 mmol) according to the general procedure M. Obtained as an orange foam (402 mg, 81%). MS (ISN) 625.9 [(M-H)-], Example M153 (2-13- [3-(6-Cvclopropyl-pyridin-3-yi)"phenvn -3-oxo-propionvlaminol-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (311 mg, 77%). MS (ISN) 538.1 [(M-H)1. Example M157 i2-[3-CtacO'3-f3-pyridin-3-vl-phenyl)-propiony1arniTio1-4-phenylethy^ carbamic add tert-butyl ester The title compound was prepared from (2-amiQO-4-phenylethynyi-phenyl)-carbamic add tert-butyl ester {CAS-No. [335255-26-0]} (231 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (322 mg, 81%). MS (ISN) 530.1 [(M-H)-], Example M158 r2-{3-[3-f5-Cvclopropyl-pyridin-2-vlVphenyl]-3-oxo-propionylamino}-5-(2.2J2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-phenyl]-cafbamic add tert-butyl ester (Example J13) (230 mg, 0.75 mmol) and 3-[3-(6-cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a light brown foam (323 mg, 76%). MS (ISN) 568.0 [(M-H)-]. Example M159 (2-{3-[3-(6-Isopropvl-pyridin-3-^)-phenyll-3-oxo-propionvlaminol-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(6-isopropyl-pyridin-3-yl)-phen^]-3-oxo-propionic add tert-butyl ester (Example K22) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous brown substance (266 mg, 65%). MS (ISN) 538.1 [(M-H)-], RYaTnpleMl6Q f2-{3-[3-(6-Isopropyl-pyridin-3-^Vphenyl1-3-oxO'propionvlainino>-5-(2.2^^^ etiioxyV4-trifluoromethyl-phenyl1-carbaim add tert-butyl ester The title compound was prepared from [2-ammo-5-(2^>2-trifluoro-ethoxy)-4-trifluoromethyi-phenylj-carbamic add tert-butyl ester (Ejcample J6) (281 mg, 0.75 mmol) and 3-[3-(6-isopropyl-pyridin-3-yl)-phen)d]-3-oxo-propionic add tert-butyl ester (Example K22) (255 mg, 0,75 mmol) according to the general procedure M. Obtained as an amorphous light brown substance (368 mg, 77%). MS (ISN) 638 [(M-H)-]. Example M161 (4-Chloro-2-{3-r3-(6-isopropyl-pyridin-3-yl-phenylnyll-3-oxo-propionyiaminol-5-methyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-araino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(6-isopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K22) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an ofif-white solid (160 mg, 41%). MS (ISN) 520 [(M-H)-] and 522 [(M+2-H)"]; mp 168 °C. Example M162 (2-13- f 3-(6-Isopropyl-pyridin-3-yD-phenyn -3-oxo-propiQnylaminol-5-meth)d-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(6-isopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K22) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (197 mg, 47%). MS (ISN) 554 [(M-H)-]; mp 154 °C Example M163 f4-CMoro*5-ethQXV-2-f3-oxo-3-(3-pyridin-3-vl-phenyl)-prQpionvlammo carbamic acid tert-butyl ester The title compound was prq>ared from {2-amino-4-diloro-5-ethox7-phenyl)-carbamic acid tert-butyl ester (Example J25) (215 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl" phenyl)-propionic add tert-butyl ester (Esample Kl) (223 mg, 0.75 mmol) according to the general procedure M, Obtained as an off-white solid (142 mg, 37%). MS (ISN) 508 [(M-H)-] and 510 [(M+2-H)"]; mp 100 °C Example M164 f4-CMoro-5-ethoxy-2-^3-r3-(2-melhvi-pyridin-4-yl)-phenyll-3-oxo-propionylam^ phenyl-carhflmif, add tert^b^t^d ester The title compound was prepared from (2-amino-4-chloro-5-ethoxy-phenyl)-carbamic add tert-butyl ester (Example J25) (215 mg, 0.75 mmol) and 3-[3-(2-methyl-pyxidin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (280 mg, 71%). MS (ISN) 522.0 [(M-H)-] and 524 [(M+2-H)-]; mp 184°C Example M165 l5-CHoro-2-r3-oxo-3-(3-pyriflin--3-Yl-pKenylVpropionylamino1-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (233 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (261 mg, 65%). MS (ISN) 532.2 [(M-H)-] and 534 [(M+2-H)1. Example M166 15-Ethoxy-2- [3-oxo-3- (3-pyridin-3-yl-phenyD-propionyIaminol -4-trifluorometfavl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-oxo-3-(3- pyridin-3-yl-phen)d)-propioiiic add tert-butyl ester (Esample Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (271 mg, 66%), MS (ISN) 542 [(M-H)-]. Example M167 i2' f 3"Qxo-3-(3-pyridin-3-vl"phenyl)-propionylamino1 ■4-trifluoromethoxy-phenyl>-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethoxy-phenyl)-carbamic , acid tert-butyl ester (Example J26) (219 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous light yellow substance (271 mg, 70%). MS (ISN) 514 [(M-H)1. Example M168 (2-(3-[3-(2'Methyl-pyiidin-4-yl)"phenyl1"3-oxo-propionylaminol-4-trifluoromethoxy-phenyl)-carhamic add tert-butyl ester The title compoxind was prepared from (2-amino-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester (Example J26) (219 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M- Obtained as an amorphous light yellow substance (275 mg, 69%). MS (ISN) 528 [(M-H)-]. Example M169 l2-f3-Oxo-3-f3-pyridin-3-vl-phenviVpropionylaiiiino1-5-pvrrolidin-l-yl-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-pyrrolidin-l-yl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J27) (259 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (259 mg, 61%). MS (ISN) 567.1 [(M-H)-]. Example Ml 70 l5-Morpholin-4'Vl-2-f3-oxo-3-(3-pyrid[in-3-vl-phenyl)-prQpionvlainm tiifluoromethyl-phenyll-carbainic acid tert-butyl ester The title compound was prepared from (2-amino-5-morpholin-4-yl-4-trifluoromethyl-plienyl)-carbamic add tert-butyl ester (Example J28) (271 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yi-phenyl)-propionic acid tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (346 mg, 79%). MS (ISN) 583.0 [(M"H)-], Example M171 (4-Chloro-2-l3-r3-f6-etfavi-pyridin-3-ylVphenyl1-3-oxo-propionylamino}-5-methyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(6-ethyl-pyridin-3-yi)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K23) (244 mg, 0.75 mmol) according to the general procedinre M. Obtained as a light yellow foam (307 mg, 81%). MS (ISN) 506.2 [(M-H)-] and 508 [(M+2-H)"]. Example M172 f 5-Ethox7-2-[3- [3-(6-ethyl-pyridin-3-yl)-phenvn -3-oxo-propion\daminol-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-ethoxy-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(6-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K23) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a yeUow solid (324 mg, 76%). MS (ISN) 570.1 [(M-H)-]; mp 123-126 °C, Example M173 r2-l3-r3-(6-ethyl-pyridin-3-viVphenyl1-3-oxo-propionvlamin phenyl Vcarbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbainic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(6-eth3d-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K23) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (296 mg, 75%). MS (ISN) 526 [(M-H)-]. Example M174 (2-(3- r3-(6-Ethyl-pyridin-3-yD-phenvn -3-oxo-propionylaminol-5-mediyl-4-trifluoromethyl-phenyl-carbamic add tert-but^ ester The title compound was prepared from (2-amino-5-metibiyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(6-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butji ester (Example K23) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (324 mg, 80%). MS (ISN) 540 [(M-H)-]. Example M175 [2-(3-r3-(6-ethyl-pyridin-3-yl)-phenyl1-3-oxo-propionvlamino>-5-(2.2.2-trifluoro-ethoxy')-4-trifluoromethyl-phenyn-carbamic add tert-butyl ester The titie compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(6-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K23) (244 mg, 0,75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (422 mg, 90%). MS (ISN) 624 [(M-H)-]. Example M176 l5-Cydopropylme&oxv-2-r3-oxo-3-(3-pyridin"3-vl"phenyl'propiony^ trifluoromethyl-phenyll-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-cydopropylme1iioxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J29) (260 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (&cample Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (311 mg, 73%), MS(ISN)568[(M-Hn. Example M177 f 5-Cydopropvlmethoxy-2-{3- f 3-(2-metfa'}d-pyridin-4-yl)-phenvn -3-oxo-propionylaniinol-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-cydopropylmethoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J29) (260 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (325 mg, 74%). MS(ISN)582[(M-H)-], Example M178 f5-Cyclopropylmethoxy-2-{3-[3-f6-cvclopropyi-pyridiTi->3-yl)-phenyl1-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-cydopropylmethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J29) (260 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl i ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (283 mg, 62%). MS(ISN)608[(M^H)-]. Example M179 f2-f3-Oxo-3-(3-pyridin-3-yl>phenviVpropionvlaminoV4-(2^,2-lTifluoro-e&^ phenyll -carbamic acid tert-butyl ester The titie compound was prepared from [2-amino-4-(2,2,2-trifluoro-ethoxy)"phenyl]-carbamic add tert-butyl ester (Ejcample J30) (230 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (298 mg, 75%). MS(ISN)528[(M-H)1. (2-l3-[3-(2-Cvano-pyridin-4-yl-phenyl1*3-oxO"propionylaminol-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K24) (242 mg, 0,75 mmol) according to the general procedure M. Obtained as an orange foam (314 mg, 80%). MS (ISN) 523.0 [(M-H)-], Example M181 (2-{3-[3-(2"Cyano-pyridin"4-'VlVphenyl1-3-oxo-propionylaminol-5-methyl-4-trifluorometbyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 romol) and 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K24) (242 mg, 0.75 mmol) according to the general procedure M. Obtained as a white solid (275 mg, 68%). MS (ISN) 537.1 [(M-H)-]; mp 97-99 °C. Example M182 r4-CHorO"2'[3-oxo-3-f3-pyridin-3-vl-phenyl)-propionvIaminQl-5-(2,2.2-tr^ ethoxy)-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-amino-4-ddoro-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester (Example J31) (256 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (282 mg, 67%). MS (ISN) 562.1 [(M-H)'] and 564 [(M+2-H)"]. Example M183 f4-CHoro-2-l3-[3-(2-cyano-pyridin-4-yl>-phenyl]"3-oxo-propiony1aTninn}-5-(2,2.2-trifluoro-ethoxy)-phenyl-carbamic add tert-butyl ester The title compound was prepared from [2-amino-4-chloro-5-(2,2,2-trifluoro-ethoxy)" phenyl]-carbamic add tert-butyl ester (Example J31) (256 mg, 0,75 mmol) and 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K24) (242 mg, 0.75 mmol) according to the general procedure M. Obtained as a colorless solid (249 mg, 53%). MS (ISN) 587-0 [(M-H)-] and 589 [(M+2-H)"];mp 116-120 °C Example M184 (2"-f3-r3"(6-Cyano-pyridin-3-ylVphenyll"3-oxO"propionvlaminol-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) (207 mg, 0 J5 mmol) and 3-[3-(6-cyano-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K26) (242 mg, 0.75 mmol) i according to the general procedure M. Obtained as a light yellow foam (305 mg, 78%), MS (ISN) 523.1 [(M-H)-], Example M185 l2'r3-OxO"3-f3"pyrida2in-3-vl"phenylVpropionvlaimnol-4-1rifluoro^^ carbamic acid tert-bulyl ester The title compound was prepared from (2-amino-4"txifluoromet3iyi-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-oxo-3-(3-pyridazin-3-yl-phenyl)-propiomc add tert-butyl ester (Example K27) (224 mg, 0,75 mmol) according to the general procedure M. Obtained as a white solid (250 mg, 67%). MS (ISN) 499.1 [(M-H)-l; mp 146-149 *°C Example M186 (2"[3-Oxo-3"(3-pyridin-2-yl-phenyl)-propionylamino1-4-trifluoromethoxy-phenyU-carbamic add tert-butyl ester The titie compound was prepared from (2-amino-4-trifluoromethoxy-phenyl)-carbamic add tert-butyl ester (Example J26) (219 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic add tert-butyl ester (Example K3) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow solid (271 mg, 69%). MS (ISN) 514.1 [(M-H)'];mp 128-130 °C Example M187 (2-(3-r3-(6-Cvclopropvl-pyridin-3-ylVphenyn-3-oxo-propionylaminol-4-trifluoromethoxy-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethoxy-phenyl)-carbamic add tert-butyl ester (Example J26) (219 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-pyridin"3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (252 mg, 60%) • MS (ISN) 554.0 [(M-H)-]. Example M188 l5-(2-Methoxy-ethoxy)-2-f3-oxo-3-f3-pyridin-3-yl-phenyD-propionylaminol-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2-methoxy-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J32) (263 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propiomc acid tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (257 mg, 60%). MS (ISN) 572 [(M"H)"]; mp 148-150 °C Example M189 f2"l3"r3-(2-CvanO"pyridin-4-yl)-phenyl)-3-oxo-propionvlarmnol"5-(2>methoxy-ethoxy^-4-trifluoromethyl-phenyn-carbamic acid tert-butyl ester The title compound was prepared from [2-amino-5-(2-methoxy-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J32) (263 mg, 0.75 mmol) and 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K24) (242 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (278 mg, 61%). MS (ISN) 597 [(M-H)1; mp 125-130 °C Example M190 (2-13- [3-f 2"Cvano-pyridin-4-yl)-phenyl1 -3-oxo-propionvlaminoK5-ethyl-4-trifluoromethyl-phenyl)-carbamic add tert-but^d ester The title compound was prepared from (2-amino-5-ethyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J33) (228 mg, 0.75 mmol) and 3-[3-(2-cyano-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K24) (242 mg, 0.75 mmol) according to the general procedure M. Obtained as a light brown solid (308 mg, 74%). MS (ISN) 551 [(M-H)-]; mp 86 °C Example M191 l5-Ethyl-2-[3-oxo-3-f3-pyridin-3-vl-phenylVpropionylamino1-4-trifluoromethyl-phenyli-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J33) (228 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yeUow oil (373 mg, 94%). MS(ISN)526[(M-H)1. Example M192 (2*l3-[3-(6-Metfaoxv-pyridin-3"VlVphenyll-3-oxo-propiQnvlaminol-4-trifluoromethoxy-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifliioromethox7-phenyl)-carbamic add tert-butyl ester (Bcample J26) (219 mg, 0,75 mmol) and 3-[3-(6'-methoxy-p7ridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example KIO) (246 mg, 0.75 mmol) according to the general procedure M. Obtained as an orange foam (226 mg, 71%). MS (ISN) 544.0 [(M-H)-]. Example M193 f2-{3- [3-(2,6"Dimethyl-pyridin-4-yl)-phenyl] -3-oxo-propion^aminoM-trifluoromethoxy-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethoxy-phenyl)-carbamic add tert-butyl ester (Example J26) (219 mg, 0.75 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (240 mg, 59%). MS (ISN) 542.1 [(M-H)-]. Example M194 12- [3-0x0-3- f 3-pyridin-3-yl-phenyD-propionylamino1 -4-trifluoromethyl-5-vinyl-phenvU-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-5-vinyl-phenyl)-carbamic add tert-butyl ester (Example J34) (227 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phen)d)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a ydlow oil(290 mg, 60%). MS (ISN) 524 [(M-H)-]. Example M195 (2-f3-Oxo-3-(3-pyriHiTi-3-yl-phenyl)-propionylamino1-5-propoxy-4-trifluorometfavl-phenvU-carbaTTiic add tert-butyl ester The title compound was prepared from (2-amino-5-propoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J35) (251 mg, 0.75 mmol) and 3-oxo-3-(3- pyridm-3-yi-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam(369 mg, 88%). MS (ISN) 556.0 [(M-H)']. Example M196 f2-B-f3-f6-Cvdoprop^-pyridin-3-yl-phenylnyl1-3-QXo-propionvlaiiunol-5-propQxy-4" trifluoromelliyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-propoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J35) (251 mg, 0.75 mmol) and 3-[3-(6-cydo-propyl-pyridin-3-yl)-phenyl]"3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam(372 mg, 83%). MS (ISN) 596.1 [(M-H)-]. Example M197 (2-l3-[3-(6-Dimel3iylamino-pyridin-3-yD-phenyl1-3-oxo-propinTiy1amino)-5-met^^ trifluoromethyl-phenyP-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg> 0.75 mmol) and 3-[3-(6-dimethylamino-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K28) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (309 mg, 74%). MS (ISP) 557 [(M+H)+]; mp 187-188 °C. Example M198 [2-{3-[3-(6-DimethAiamino-pyridin"3-vD-phenyl1-3-oxo-propionvlaminol-5-(2.2.2-trifLuoro-ethoxyV4-trifluoromethyl-phenvn-carbamic add tert-butyl ester The title compound was prepared from [2-aminO"5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(6-dimethylamino-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K28) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as a light brown solid (409 mg, 85%). MS (ISP) 641 [(M+H)+]; mp 167-169 °C Example M199 f2-{3-[3-(2.6-Dimedivl-pyridin-4"yiVphenyl1-3-QXO-propionvlamm^ trifluorometfavl--phenyl)-carhaTnic acid tert-bulyl ester The title compound was prepared from (2-aniino-5-propoxy'-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J35) (251 mg, 0.75 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phen)i]-3-oxo-propionic add tert-butyl ester (Example K15) (244 mg, 075 mmol) according to the general procedure M. Obtained as a light yeUow solid (172 mg, 49%). MS (ISN) 596-1 [(M-H)-]. Example M200 (2-B- [3-(2-Cvdopropvl-pyridin-3-yl)-phenvn -3-oxo-propionylaminol-4-trifluorometfayl-phenyl-carbamic add tert-but^ ester The title compound was prepared from (2-amino-4-trifiuoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(2-cydopropyl-pyridin-3-^)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K29) (253 mg, 0.75 nrniol) according to the general procedure M. Obtained as a yellow oil (223 mg, 58%). MS (ISN) 538.1 [(M-H)-]. Example M201 (2-B-[3'f2-Cvdopropvl-pyridin-3-vl)"phenyl]-3-oxo-propionylaminol-5-metfa\d-4-trifluorometfayl-phenyl-carbamic acid tot-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K29) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a ydlow oil (255mg,61%). MS (ISN) 552.0 [(M^H)-], Example M202 (2-13- F3-f 2-Metfavl-pyridiT>-4-yl)-phenyl1 -3-oxo-propionvlaininol-5-propyl-4-trifiuoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-propyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J36) (239 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-plienyi]-3-oxo-propionic acid tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (292 mg, 70%), MS (ISN) 554 [(M-H)']. Example M203 (5-ethyl-2-l3- [3-(2-methyl-pyridin-4-^Vphenyn -3-oxo-propiony[aminol-4-trifluoromethyl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-ethyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J33) (152 mg, 0,5 mmol) and 3-[3-(2-methyl-pyTidin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (156 mg, 0.5 mmol) according to the general procedure M. Obtained as a Ught yellow foam (213 mg, 79%). MS (ISN) 540 [(M-H)-]. Example M204 (2-{3-[3-f6-Cyclopropyl-pyridin-3-yD-phen'vi1-3-oxo-propiony1aTninn}-S*propyl-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-propyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J36) (239 mg, 0.75 mmol) and 3-[3"(6-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow solid (274mg,63%). MS (ISN) 580 [(M-H)-]. Example M205 (2-13- f 3-f 6-CvdoprQpyl-pyridin-3-yl-phenylnvn -3-oxO"propionylamino^-5-ethyl-4-trifluoromethyl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-ethyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J33) (152 mg, 0,5 mmol) and 3-[3-(6-cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K21) (169 mg, 0.5 mmol) according to the general procedure M. Obtained as a light yellow foam (211 n^, 74%).. MS(ISN)566[(M-H)-]. Example M206 (2-{3-[3-(4-Methyl-pyridin"3-ylVphenyll-3-oxo-propionylarninn}-4-iTifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3"[3-(4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K30) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (276 mg, 72%). MS (ISN) 512.2 [(M-H)-]. Example M207 (2-{3-[3-f2-Cydopropyl-pyridin-3-yD-phenvn-3-oxo-propionvlaminol-5-ethoxy-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butji ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(2-cydopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K29) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (210mg,48%). MS (ISN) 582.0 [(M-H)']. (2-i3-f3-(2.6-Dimetfavl"pyridin-4-vIVphenyl1-^^ trifluoromethyl-phenyl)-carbaiiuc add tert-but^d ester The title compound was prepared from (2-ainino-5-ethyl-4-trifluoromethyi-phenyl)-carbamic add tert-butyl ester (Example J33) (152 mg, 0.5 mmol) and 3-[3-(2,6-dimeth)d-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (163 mg, 0.5 mmol) according to the general procedure M. Obtained as a white solid (185mg>67%). MS(ISP)556[(M+Hr]. RYample U209 f 2-f 3- [3"f 2,6-Dimethyl-pyridin'4-yl)-phenyl1 -3-oxO"propionvlaniinol-5-propyl-4-trifluoromethyl-phenviVcarbamic addtert-butyl ester The title compound was prepared from (2-amino-5-propyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J36) (239 mg, 0.75 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a white solid (325 mg, 76%). MS (ISN) 568 [(M-H)-]. Example M210 {2-[3-Oxo-3-f3-pyridin-3-yl-phenyD-propionvlaminol-5-propyi-4-trifluoromethyl* phenyll-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-propyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J36) (239 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic add tert-butyl ester (Example Kl) (223 mg, 0,75 mmol) according to the general procedure M. Obtained as a yellow oil (180 mg, 44%). MS(ISN)540[(M-H)1. &campleM211 f5-ethoxy-2-{3-[3-r4-melhvl-pyridin-3-yl-phenylnyl1-3-oxo-prQpion'^ trifluoromethvi-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (2-aniino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(4-methyl-pyridiQ-3-yl)-plienyl]-3-oxo-propionic add tert-butyl ester (Example K30) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a ydlow foam (314 mg, 75%). MS (ISN) 556.0 [(M-H)-]. Example M212 f2-{3-[3-f4-Methyl-pyridin-3-ylVphen^1-3-oxo-propionyiaminol-5-(2^^-trifluoro-ethoxy')-4-trifluoromethyl-phenyl1-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4" trifluorometh]4-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(4-medi)d-pyridin-3-"jd)-phenyl]-3-oxO"propiomc add tert-butyl ester (Example K30) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a Ught yellow foam (380 mg, 83%). MS (ISN) 609.9 [(M-H)-]. Example M213 (5-Methyl-2-f3-f3-(4-methyl-pyridin-3-yl)-phenyl1-3-oxo-propinTiy1arninol-4-trifluorometfavl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K30) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a white solid (301 mg, 76%). MS (ISN) 526.0 [(M-H)-]; mp 167-169 °C. Example M214 f2-{3-r3-(2-Ellivl-pyridin-3"ylVphenyl1-3-oxo-propionvlamm trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-artiino-5-methyl-4-trifluoromethyl-ph carbamic acid tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2-ethyl-pyridin-3-yl)"phenyl]-3-oxo-propionic add tert-butyl ester (Example K31) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous off-white substance (346 mg, 85%). MS(ISN)540[(M-H)-]. Example M215 (5-Ethoxy-2-B-f3*(2-ethyl-pyridin-3-ylVphenyl1"3-oxo-propinnYlflmiTif>}-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(2-ethyl-^ pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K31) (244 mg, 0.75 mmol) according to the general procediure M. Obtained as an amorphous yellow substance (294 mg, 69%). MS(ISN)570[(M-H)-]. Example M216 [2-{3-[3-(2-Ethyl-pyridin-3-yD-phenyl1-3-oxo-propionylaminol-5-(2.2,2-trifluorQ-ethoxyV4-trifluoromethyl-phenyl]-carbamic add tert-butsd ester The title compound was prepared from [2-amino-5"(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(2-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester > (Example K31) (244 mg, 0.75 mmol) according to Ihe general procedure M. Obtained as an amorphous yellow substance (373 mg, 80%). MS(ISN)624[(M-H)']. Example M217 (5-Metfavl-2-l3-r3-(6-me1hvl-pyridin-3-yl-phenylnyl1-3'OXO-^^ Ixifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-metbyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phen)d]-3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous off-white substance (331 mg, 84%), MS(ISN)526[(M-H)-]. Example M218 f5-Ethoxy-2-^3-f3-(6-methyl>pyridin-3-^d)-phenyl1-3'OXo-propionylaminol-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (301 mg, 72%). MS(ISN)556[(M-H)-]. Example M219 [2-{3-r3-(6-Metfayl-pyridin-3-yl)-phenyl')-3-oxo-propionylaminol-5-(2,2.2-trifluoro-ethoxy)-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethox7)-4-trifluoromethyl-phenylj-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(6-methyl-pyridin-3-yl)-phenyl]>3-oxo-propionic add tert-butyl ester (Example K4) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous light brown substance (231 mg, 50%). MS(ISN)610[(M-H)-]. KYample M22Q f2-B*f3-(2.6-Dimediyl-pyridin-4-yl)-phenyll-3-oxo-propionvlaroin^ trifluoromethyl-phenyl)-carbamic addtert-butyl ester The title compound was prepared from (2-ammo*5-fluoro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J37) (221 mg, 0.75 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)"phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (301 mg, 74%). MS (ISP) 544.1 [(M+H)+]. Example M221 (2"{3-[3-(2,6-Dimethy1"pyridin-4-yl)-phenyl1-3-oxO"propionvlaminol--4-trifluoromethyl-5-vinvi-phenyl-carbamic add tert-butyl ester The title compotmd was prq)ared from (2-amino-4-trifluoromethyl-5-vin)d"phenyl)-carbamic acid tert-butyl ester (Example J34) (227 mg, 0.75 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow solid(199mg,48%). MS (ISN) 552.0 [(M-H)-]; mp 169 °C (dec). Example M222 (5-(2-Methoxy-ethoxy)-2-f3-f3-(2-methyl-pyridin-4-yl)-phenvn-3-oxo-propionylaminol-4'trifluoromethyl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from [2-amino-5-(2-methoxy-ethoxy)-4-trifluoromethyl-phenylj-carbanaic add tert-butyl ester (Example J32) (263 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (351 mg, 80%), MS(ISN)586l(M-H)-]. Example M223 f 2-13- [3-f 2.6-Dimethyl-pyTicim-4-yl)-phenyl1 -3-oxo-propion^aminoK5-f 2-inethoxy-ethox7)-4-trifluoromethyl-phenyl]-carbainic add tert-butyl ester The title compound was prepared from [2-amino-5-(2-methoxy-ethox7)-4-trifluorometh)d-phenyl]-carbamic add tert-butyl ester (Example J32) (263 mg, 0.75 mmol) and 3-[3-(2,6-dimetbjd-pyridin-4-yl)-plienyl]-3-oxo-propionic add tert-butyl ester (Example K15) (244 mg, 0.75 mmol) according to the general procedure M-Obtained as a light yellow solid (337 mg, 75%), MS(ISN)600[(M-H)-]. Example M224 (2-^3- [3-(2-Methyl-pyridin-4-yl)-phenyl1 ■3-oxo-propionylaniinol-4-trifluoromethyl-5' vinyl-phen^ Vcarbamic add tert-butyl ester The title compound was prepared from (2-anuno-4-trifluoromethyl-5-vinyl-phenyl)-^ carbamic add tert-butyl ester (Example J34) (227 mg, 0.75 imnol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow solid (313 mg, 77%). MS (ISN) 538 I(M-H)-]. Example M225 (2-{3-[3-(4.6-Dimethyl-pyridin-3-yl)-phenyll-3-oxo-propion^amino)-5-methyl-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(4,6-dimethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K32) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (322 mg, 79%). MS (ISN) 540.3 [(M-H)1. Example M226 f2-l3-[3-(6-Cvdopropyl-4-methyl*pyridin-3-yl)-phenyll-3-oxo-^^ metfavl-4-trifluoromethyl-phenylVcarbamic acid tert-butyl ester The title compound "was prepared from (2-amino-5-methyl-4-trifluoromethyl-phen)d)-carbamic acid tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K33) (264 mg, 0-75 mmol) according to the general procedure M. Obtained as an amorphous light yellow substance (318 mg, 75%), MS(ISN)566[(M-H)-], Example M227 (2-{3-[3-f6-Cyclopropyl-4-methyl-"pyridin-3-yl-phenylnyll-3-oxo-propionylaininol-5-ethoxy-4-trifluorometfavl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K33) (264 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous light yellow substance (345 mg, 77%), MS(ISN)596[(M-H)-]. Example M228 [2-l3-[3-(6-Cyclopropvl-4-methyl-pyridin-3-yD-phenyl1-3-oxo-propionvlaminol-5-f2.2.2-trifluoro-ethoxyV4-trifluoromethyl-phenyl1-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2"trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K33) (264 mg, 0.75 mmol) according to the general procedture M. Obtained as an amorphous light yellow substance (353 mg, 72%). MS(ISN)650I(M-H)-]. Example M229 (2-B-[3-(2-Etfavi-6-methyl-pyridin-4-yl)-phenyl1-3-QXO-pro^ trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared jfrom (2-amino-5-methyl-4-trifluorometbjd-phenyl)-caibamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2-ethyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K34) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous light yellow substance (332 mg, 80%). MS (ISN) 554 [(M-H)-]. Pyample Ml^O f5"Ethoxy-2"{3-[3-(2-ethyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propinny1flminn trifluorometfayl-phenyP-carbamic add tert-butyl ester The title compound was prq>ared from (2-amino-5-ethoxy-4-trifluorome1hyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(2-ethyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K34) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous light yellow substance (336 mg, 77%). MS(ISN)584[(M-H)-]. Example M231 f2--{3-[3-(2-Ethyl-6-methyl-pyridin-4-yl)"phenyl1-3-oxo-propionvlaiiunol-5-(2^^^ trifluoro-ethoxyV4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (281 mgy 0.75 mmol) and 3-[3-(2-ethyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K34) (255 mg, 0.75 rxmiol) according to the general procedure M. Obtained as an amorphous light yellow substance (421 mg, 88%). MS(ISN)638[(M-H)-]. Example M232 (2-^3-f3-(4.6-Dim€thvl-pyridin-3-vD-phenyl1-3-oxO"propionvlamino trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluorometh)i-phenyl)-carbamic acid tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(456-dimethyl-pyridin-3-yl)-phen;5i]-3-oxo-propionic add tert-butyl ester (Example K32) (244 mg, 0,75 mmol) according to the general procedure M, Obtained as a light yellow foam (350 mg, 82%). MS (ISN) 5703 [(M-H)-]. Example M233 f 2-13- f 3-f 4.6-Dimedi\d-pyridin-3-yD-phenyll ■3-oxo-propionylaminol-5-f 2^.2-trifluoro-ethoxy)-4-trifluorometfavl-phenyl1-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(4,6-dimethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K32) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a li^t brown foam (388 mg, 83%). MS (ISN) 624.2 [(M-H)-]. Example M234 f2-{3-[3-f6-Etfavl-4-methyl-pyridin-3-vD-phenyl1-3-oxo-propionylamiiin}-_S-rnethyl-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(6-ethyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K35) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous red substance (184 mg, 44%). MS (ISN) 554 [(M-H)-]. Example M235 (5-ethoxy-2-l3-[3*(6-ethyl-4-methyl-pyridin-3-ylVph trifJuorometfayi-phenylVcarbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-ethox7-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(6-ethyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxO"propiomc add tert-butyl ester (Example K35) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous red substance (184 mg, 42%). MS(ISN)584[(M-H)-]. Example M236 [2-(3-f3-(6-Elhyl-4-metfayl-pyridin-3-vi>*phenyll-3-oxo-propionylamino>-5-(2,2.2-trifluoro-ethoxy')-4-trifluoromethyl-phen)d]-carbamic add tert-butyl ester The title compound was prq^ared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0J5 mmol) and 3-[3-(6-ethyl-4-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K35) (255 mg, 0,75 mmol) according to the general procedure M. Obtained as an amorphous red substance (229 mg, 48%). MS(ISN)638[(M-H)-]. Example M237 f2-{3-[3-f2-Cvdopropvl-6-metfavl-pyridin-4-yl)-phenylV3-oxo-propionvlaminol-5-metbyl-4-trifluoromethyl-phenyl')-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2-cyclopropyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example ¥36) (264 mg, 0.75 mmol) according to the general procedure M- Obtained as an amorphous ydlow substance (309 mg, 73%). MS(ISP)568[(M+Hr]. Example M238 (2-l3-r3-(2-Cvdoprop->d-6-methyl-pyridin-4-'d)-phenyl1-3-oxo-propionylai^ ethoxy-4-lxifluoroinethyld-pheiiyiVcarbamic add tert-butyl ester The title compound was pTq)aied from (2"amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-bulyl ester (ficample J8) (240 mg, 0.75 mmol) and 3-[3-(2-q^dopropyl-6-meth}d-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K36) (264 mg, 075 mmol) according to the general procedm-e M. Obtained as an amorphous yellow substance (282 mg, 63%). MS (ISP) 598 [(M+H)+]. Example M239 [2-f3-f3-(2-Cvdopropyl-6-methyl-pyridin-4-yl-phenyl]"3"OXO-propion^aminol-5" (2.2.2-trifluoro-ethoxy)-4-trifluorometfayI-phenyl]-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-etiioxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(2-cyclopropyl-6-methyl-pyridin-4-yl)-phenyl]-3-oxo-propiomc add tert-butyl ester (Example K36) (264 mg, 0.75 mmol) according to the general procedure M- Obtained as an amorphous yellow substance (347 mg, 71%). MS(ISP)650[(M+H)1. Example M24Q (5-Methyl-2-f 3- r3-(2-methyl-pyridin-3-vl)-phenyl1 -3-oxo-propionylaminol-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (357 mg, 1.23 mmol) and 3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K5) (383 mg, 1.23 mmol) according to the general procedure M. Obtained as a Ught yellow foam (426 mg, 66%). MS (ISN) 526.1 [(M-H)-]. Example M241 f2-B-[3-f2-Meliiyl-pyri The title compotind was prepared from [2-ainiiio-5-(tetraliydro-pyran-2-yioxyinethyl)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J38) (293 mg, 0.75 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic addtert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (168 mg, 36%), MS (ISN) 626 [(M-H)-]. Sample M242 (2-{3-[3-(2-Isobutyl-pyridin"4-yl)-phenyl1-5-methyl*3-oxo-propionylaTnmn}-^^ trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-anaino-5-methyl"4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (203 mg, 0.70 mmol) and 3-[3-(2-isobutj4-pyridin-4-yl)-phen)d]-3-oxo-propionic add tert-butji ester (Example K37) (247 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid (290 mg, 73%). MS (ISP) 568.3 [(M-H)-]; mp 129 °C Example M243 [2-l3-[3-(2-Isobutyl-pyridin-4-yl)-phenyn-3-oxo-propionvlaminol-5-(2^.2-trifluoro-ethoxy)-4-trifluoromethyl-phenyn-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (262 mg, 0.70 mmol) and 3-[3-(2-isobutjrl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K37) (247 mg, 0.70 mmol) according to the general procedure M. Obtained as a light brown oil (320 mg, 70%). MS (ISP) 652.2 [(M-H)']. Example M244 (4"Chloro-5-metfayl"2-{3"Oxo-3- f 3-f 2-trifluoromethyl-pyridin-4-yl)-phenyl] ■ propionylaTninn}-pheiiyD-carbamic acid tal-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic add tert-butyl ester (Example J22) (180 mg, 0.70 mmol) and 3-oxo-3-[3-(2-trifluoromethyl-pyridin-4-yl)-phen)i]-propionic acid tert-butyl ester (Example K38) (256 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid (270 mg, 70%). MS (ISP) 546.2 [(M-H)-]; mp 188 °C Example M245 (5-Methyl-2-(3-oxo-3-[3-f2-trifluoromelhyl-pyridin-4-yl-phenyll-propionylanm trifluoromethyl-phenyP-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-meth)d-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J20) (203 mg, 0.70 mmol) and 3-oxo-3-[3-(2-trifluoromethyl-pyridin-4-yl)-phenyl]-propionic acid tert-butyl ester (Example K38) (256 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid (290 mg, 71%). MS (ISP) 580.2 [(M-H)1; mp 117 °C. Example M246 f5-Chloro-2-l3-oxo-3-[3-(2-trifluoromethyl-pyridin-4-yl-phenyl1-propionylaminol-4-trifluoromethyl-phenyP-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (218 mg, 0.70 mmol) and 3-oxo-3-[3-(2-trifluoromethyl-pyridin-4-yl)-phenyl]-propionic add tert-butji ester (Example K38) (256 mg, 0.70 mmol) according to the general procedure M. Obtained as a light brown solid (260 mg, 62%). MS (ISP) 600,1 [(M-H)']; mp 132 °C Example M247 r2-l3-Oxo-3-[3-(2-1xifluorometiivl>pyridin-4-yl)-phenylVpropion^ trifluoro-ethoxyV4-1rifluorometiivl-phenyl1-carbamic addtert-butyl ester The title compound was prepared from [2-ammo-5-(2>2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (262 mg, 0.70 mmol) and 3-oxo-3-[3-(2-trifluoromethyl-pyridin-4-)d)-phenyl]-propionic acid tert-butyl ester (Example K38) (256 mg, 0.70 mmol) according to the general procedure M. Obtained as a light brown foam (440 mg, 94%). MS (ISP) 624.2 [(M-H)-]. Example M24« f5-ethoxy-2-(3-oxo-3-f3-(2-trifluorometfayl-pyridin-4-yl-phenyl1-propionyiamino}-4-trifluoromethyl-phen^Vcarbamic acid tert-butyl ester The title compound was prq)ared from [2-amino-5-ethox7-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (224 mg, 0.70 mmol) and 3"0XO-3-[3-(2-trifluoromethyl-pyridin-4-)d)-phenyl]-propionic add tert-butyl ester (Example K38) (256 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid(320mg,75%). MS (ISP) 610.1 [(M-H)-]; mp 140 °C Example M249 ( 4-Chloro-2-l3- [3-(2-isopropyl-pyridin-4"yD-phenyl] -5-methyl-3-oxo-propionylamino^-phenyl)-carbamic acidtert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phen)d)-carbamic acid tert-butyl ester (Example J22) (193 mg, 0.75 mmol) and 3-[3-(2-isopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K39) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (340 mg, 87%). MS (ISP) 520.2 [(M-H)1; mp 168 °C. Example M25Q (2-{3-[3-(2-Isopropyi-pyridin-4-yl)-phenyl1-5-methyl-3-oxo-propionylai^ trifluoromethyl-pIienvlVcarbamic addtert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3"(2-isopropyl-pyridin-4-yl)-phenyl]-3-oxo-propiomc add tert-butyl ester (Example K39) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (230 mg, 55%). MS (ISP) 554.2 [(M-H)-]; mp 150 °C Example M251 (2-B-f3-f2-Isopropvl-pvndin-4-yl)-phenyll"3-oxo-propion^aTninn}-4-trifluoromet^^^ phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifiuoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(2-isopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K39) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (250 mg, 62%). MS (ISP) 540.3 [(M-H)-]; mp 127 °C Example M252 (5-Chloro-2-(3-[3-f2-isopropyl-pyridin-4-yl)-phenyl1-3-oxo-propionvlaminol-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (233 mg, 0.75 mmol) and 3-[3-(2-isopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K39) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (240 mg, 56%). MS (ISP) 574.2 [(M-H)-]; mp 144 °C. Example M253 [2-{3-[3-f2-Isopropyl-pyridin-4-yl)-phenyl1-3-Qxo-propionvlammolr5"(2,2,2-ttrifluoro ethoxy)-4-trifluoromethyl-phenyl1-carbamic acid tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethox7)-4-trifluoromethod-phenyl]-carbamic add tert-bulyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(2-isopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Bcample K39) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as a light brown solid (360 mg, 75%). MS (ISP) 638.2 [(M-H)-]; mp 151 °C. Example M254 5-Ethoxy- [2-{3- [ 3-f 2-isopropvl-pyridin-4-yl)-phenyll -3-oxo-propionylammo)-4-trifluoromethyl-phenyl] -carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-ethoxy-4-trifluorometh7i-phenyl]-carbamic add tert-butyl ester (Example J6) (240 mg, 0.75 mmol) and 3-[3-(2-isopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K39) (255 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white solid (340 mg, 77%). MS (ISP) 584.3 [(M-H)-]; mp 154 °C. Example M255 f 5-Chloro-2-l3- r3-(2-isobutyl-pyridin-4--\d)-phenyl1 -3-oxo-propionvlamino}-4-trifluoromethvi-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example 119) (218 mg, 0.70 mmol) and 3-[3-(2-isobutyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K37) (247 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid (320 mg, 77%). MS (ISP) 588.3 [(M-H)1; mp 125 °C. Example M256 (4-CMoro-2-(3-[3-(2-isobutyl-pyridin-4-yl-phenyl]-5-methyl-3-ox phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)"Carbamic add tert-butyl ester (Example J22) (180 mg, 0.70 mmol) and 3-[3-(2-isobutyl-pyiidin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K37) (247 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid (310 mg, 83%). MS (ISP) 5343 [(M-H)-]; mp 143 °C. Example M257 5-Ethoxy-[2-(3- [3-f 2-isobutyl-pyridin-4-yl)-phenyn -3-oxo-propionylaminol-4-trifluoromethyl-phenvn-carbamic acid tert-butyl ester The title compound was prepared from [2-amino-5-ethoxy-4-trifluoromethyl-phenyl] -carbamic add tert-butyl ester (Example J6) (224 mg, 0.70 mmol) and 3-[3-(2-isobutyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K37) (247 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid (310 mg, 74%). MS (ISP) 598.2 [(M-H)-];mp 151 °C. Example M258 (2-f3-[3-(2-Isobutyl-pyridin-4-yl)-phenyl]-3-oxo-propionylaminol-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluorometh)d-phenyl)-carbamic add tert-butyl ester (Example J3) (193 mg, 0.70 mmol) and 3-[3-(2-isobutyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K37) (247 mg, 0.70 mmol) according to the general procedure M. Obtained as an off-white solid (260 mg, 67%). MS (ISP) 554.3 [(M-H)-]; mp 110 °C Example M259 (RS)-[4-Chloro-5-methyl-2-(3-oxo-3-l3-f2-rtetrahvdro-pvran-2'Vloxvm 4-yl1-phenyll-propionylarninn)-phenyl1-carbamic add tert-butyld ester The title compound was prepared from (2-amino-4-chlorO"5-metiijd-phenyl)-carbaimc add tert-butyl ester (Example J22) (257 mg, LO mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yioxymediyl)-pyridin-4-)d]-plienyl}-propionic add tert-butyl ester (Example K40) (412 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown solid (510 mg, 86%). MS (ISP) 592.3 [(M-H)-]; mp 64 °C, Example M260 (RS)-[5-Metfavl-2-f3-oxo-3-l342-ftetrahydro-pvran-2-yloxvmethyl)-p\ni phen^dl-propionylamino)-4-trifluoromethyl-phenyl]-carbamic.add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (4.40 g, 15.0 mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)"pyridin-4-yl]-phenyl}-propionic add tert-butyl ester (Example K40) (6.24 g, 15.0 mmol) according to the general procedure M. Obtained as a light ydlow foam (6.20 g, 65%). MS (ISP) 626.3 [(M-H)-]. Example M261 (RSV f 5-Chloro-2-(3-oxo-3-f3-[2-(tetrahvdrO"pvran-2-vloxvmethylVpyridin-4-vn -phenyU-propionvlamino)-4-trifluorometfa^-phenyl]-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-but)d ester (Example J19) (311 mg, 1.0 romol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic add tert-butyl ester (Example K40) (412 mg, LO mmol) according to the general procedure M. Obtained as a light yellow solid (550 mg, 85%). MS (ISP) 646.2 [(M-H)']; mp 81 °C. Example M262 (RSV[2-(3-Oxo-3-(3-f2-rte1xahycko-pvran-2-vloxymethyl)-pyridm propionvlaminoV5-(2,2.2-lTifluoro-eliioxyV4-1rifluoromet^^ tert-butyl ester The title compound was prepared from [2"amino-5-(2,2,2-trifluoro-etibox7)-4-trifiuoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (374 mg, 1.0 mmol) and (RS)-3-oxo-3-{3-[2"(tetrah7dro-pyran-2-yloxymethyl)-pyridin-4^^ propionic add tert-butyl ester (Example K40) (412 mg, LO mmol) according to the general procedure M. Obtained as a ligbt brown solid (500 mg, 70%). MS (ISP) 710.2 [(M-H)']; mp 168 °C Example M263 (RS)-f5-ethoxy-2-f3-oxo-3-B-r2-(tetrahvdro-pvran-2-vloxvmethyl)-pyrid^ phenyl}-propionyIamino-4-trifluoromethyl-phenyn-caibamic acid tert-butyl ester The title compound was -pxepzxed from [2-amino-5-ethoxy'-4-trifluorometh)d-phenyl]-carbamic add tert-butyl ester (Example J6) (320 mg, 1.0 mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phen}i}-propionic add tert-butyl ester (Example K40) (412 mg, 1.0 mmol) according to the general procedure M. Obtained as an off-white solid (500 mg, 76%). MS (ISP) 656.3 [(M-H)-];mp 127°C Example M264 (2-l3-[3-(6-Cydopropyl-4-methyl-pyridin-3-yl-phenyl]-3-oxo-propionylaminol-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared from (2-amiao-4-trifluorome11iyl-phenyl)-carbamic add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(6-cydopropyl-4-methyl-pyridin"3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K33) (264 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous off-white substance (297 mg, 72%). MS(ISN)552[(M^H)"]. Example M265 (2-{3-[3-(4,6-Dimethyl-pyridin-3-yl)-phenyl-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carhamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(4,6-dimethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K32) (244 mg, 0.75 mmol) according to tbe general procedure M. Obtained as a white foam (320 mg, 81%). MS(ISN) 526.1 [(M-H)-]. Example M266 (2-{3-(3-(2-Cvclopropyl-pyridin-4-yl)-phenylV3-oxo-propionylamino}-4-trifluoromethyl-phenyl-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(2-cydopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K60) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous white substance (315 mg, 75%). MS (ISN) 538 [(M-H)-]. Example M267 (2-(3-[3-2-Cvdopropyl-pYridiri-4^ylVphenyl1-3-oxo-propionylaminol-5"methyl-4 trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compotmd was prepared from (2-amino-5-meth)d-4-trifLuoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2-cydopropyl-pyTidin-4-"5d)-phenyl]"3-oxo-propionic add tert-butyl ester (Example K60) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous off-white substance (328 mg, 79%). MS (ISN) 552 [(M-H)-]. Example M268 f2-^3-[3-(2-Cyclopropyl-pyridin-4-yl)-phenyl1-3-oxo-propionylaminol-5-ethoxy-4-trifluorometfavl-phenyl-carbamic add tert-butyl ester The title compound was prepared (2"amino-5-ethoxy-4-trifluoronaethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(2-cydopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K60) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous off-white substance (337 mg, 77%). MS (ISN) 582 [(M-H)-]. Example M269 [2-{3-[3-(2"Cydopropyl-pyndin-4-yl)-phenyll-3-Qxo-propionvlaniinol-5-(2^,2" trifluoro-ethoxy)-4-trifLuoromethyl-phenvil-carbamic acid tert-butyl ester The title compound was prepared [2-anuno-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenylj-carbamic add tert-butyl ester (Example J6) (281 mg> 0.75 mmol) and 3-[3-(2-cydopropyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K60) (253 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous off-white substance (391 mg> 82%). MS(ISN)636[(M-H)-]. Example M270 f5-Cyclopropyi-2-l3-[3-(2-methyl-pyridin-4-yl-plienyl1-3-oxo-propionyiamino}-4-trifluoromethyl-phenyP-carbamic add tert-butyl ester The title compound was prepared (2"amino-5-cydopropyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J39) (289 mg, 0.914 mmol) and 3-[3"(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (284 mg, 0.914 mmol) according to the general procedure M, Obtained as a yellow foam (368 mg, 73%). MS (ISN) 552.2 [(M-H)-]. Example M271 (2-{3-l'3-(2-Cvclopentvl-pyridin-4-yl)-phenyll-3-oxo-propionylaminol-5-methyl-4-trifluoromethyl-phenyl-carbamic acid tert-butyl ester The title compound was prepared jfrom (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-[3-(2-cydopentyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K61) (274 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yeUow foam (369 mg, 86%). MS (ISN) 580.4 [(M-H)-]. Fyflmple M272 (2-(3-f3-r2-Cvdopentvl-pyridin-4-yl)-phenyl1-3-oxo-propionvlamino}-4-trifluorometfayl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4rtrifluoromethyl-phenyl)-carbaimc add tert-butyl ester (Example J3) (207 mg, 0.75 mmol) and 3-[3-(2-qrdopentyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K61) (274 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (320 mg, 75%). MS (ISN) 566.4 [(M-H)-]. Example M273 (2-l3-[3-(2"CydopentYUpYriHin-4-y1)-phenylV3-oxo-propionylamino^-5-ethoxy^ trifluoromethyl-phemidVcarbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[3-(2-cydopentyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K61) (274 mg, 0.75 mmol) according to the general procedure M. Obtained as a H^t yellow solid (366 mg, 80%). MS (ISN) 610.4 [(M-H)-]; mp 154-156 °C Example M274 f2-f3-[3-(2-Cvdopentyl-pyridin-4-yl-phenyll-3-oxo-propionvlaminol-5-(2^^-trifluoro-ethoxy)-4-trifluoromethyl-phenyl1-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(2-cydopentyi-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K61) (274 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (410 mg, 82%). MS (ISN) 664.3 [(M-H)1. Example M275 (5-fIsQbutyl-methyl-aminoV2-l3-[3-(2-methyl-pyridin-4-yl)-phenyl1-3-oxo-propionylaminol-4-trifluQrQmetfavl-phenyl-carbamic add tert-butyl ester The title compound was obtained from [2-amino-5-(isobutyl-methyl-amino)-4-trifluoromethyl-phenylj-carbamic acid tert-butyl ester (Example J40) (361 mg, 1.0 nimol) and 3-[3-(2-methyl'pyridin-4-yl)-phenyl]-3-oxo-propionic acidtert-butyl ester (E3cample K12) (311 mg, 1.0 mmol) according to the general procedure M as a pink solid (450nig,75%). MS (ISP) 599.4 [(M+H)+]; mp 123 °C Example M276 (5- Qsopropvl-methyl-amino V2-I3- [3-(2-methyl-pyridin-4-yl)-phenyll -3-oxo-propionylaminol-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was obtained from [2-amino-5-(isopropyi-methyl"amino)-4-trifluoromethyl-phenylj-carbamic acid tert-butyl ester (Example J41) (347 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M as a light brown solid (450 mg, 77%). MS (ISP) 585.4 [(M+H)+]; mp 146 °C. Example M277 (4"CHoro*5-(isobutyl"methyl-aminoV2--[3-[3-f2-metfayl-pyridin-4-yl)-phenyll-3-oxo-propionvlaminol-phenyl)-carbamic acid tert-butyl ester The title compound was obtained from [2-arnino-4-chloro-5-(isobutyl-methyl-amino)-l-phenyl]-carbamic acid tert-butyl ester (Escample J42) (328 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M as an off-white solid (410 mg, 73%). MS (ISP) 563.4 [(M-H)-]; mp 109°C Example M278 (2-B-r3-(2-Methyl-pyridin-4-yl)-phenyll-3-oxo-propionvlaininol-5-pyrrohdin-l-yl-4-trifluoromethyl-phenyP-carbamic acid tert-butyl ester The title compound was obtained from (2-amino-5-pyrrolidine-l-yl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J27) (345 mg, 1.0 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K12) (311 mg, 1.0 mmol) according to the general procedure M as a yellow solid (350 mg, 60%). MS (ISP) 581.4 [(M^H)"]; mp 114 °C. Eramplg M279 (RS)-[5"QsobulTl-metfavl"aTTiinoV2-r3^oxO'3-l3-f2-(tetTahvdro-pvran-2-^^^ pYridin-4-Yl ] -phenyU-propionylamino V4-trifluoromethyl-pheiiy1 ] °Carhamic acid tert-butyl ester The tide compound was obtained from [2-amino-5-(isobutyl-methyl-amino)-4-trifiuoromethyl-phenylj-carbamic add tert-butyl ester (Example J40) (4.39 g, 12.1 mmol) and (RS)-3-oxo-3-{3-[2-(tetraliydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic add tert-butyl ester (Example K40) (5*0 g, 12.1 mmol) according to the general procedure M as a light brown foam (5.83 g, 69%). MS (ISP) 699.5 [(M+H)+]. Example M280 (RSV[4-Chloro-5-fisopropvl-methyl-aminoV2-(3-oxo-3-l3-r2-ftetrahvdro-pyran-2-yloxvniethylVpyridin-4-yl1-phenyl}-propion^anuno)-phenyll-carbanuc add tert-butyl ester The title compound was obtained from [2"amino-4-chloro-5-(isopropyl-methyl-amino)-l-phenyl]-carbamic add tert-butyl ester (Example J43)(314 mg, 1.0 mmol) and (RS)-3-oxo-3-{3- [2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propioiiic add tert-butyl ester (Example K40) (412 mg, 1,0 mmol) according to the general procedure M as a Ught brown foam (360 mg, 55%). MS (ISP) 649.5 [(M-H)']. Example M281 fRS)-r4-Cbloro-5-(isQbutyl-methyl-amino)-2-f3-oxo-3-l3-[2-ftetrahvdro-pvran-2-vloxymethyl)-pyridin-4-yl]-phenvU-propionylaniino)-phenyl1-carbamic add tert-butyl ester The title compound was obtained from [2-arnino-4-chloro-5-(isobutyl-methyl-ainino)4-phenylj-carbamic add tert-butyl ester (Example J42) (328 mg, 1.0 mmol) and (RS)-3-oxO"3-{3- [2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic add tert-butyl ester (Example K40) (412 mg, 1.0 mmol) according to the general procedmre M as a Kght brown foam (350 mg, 53%). MS (ISP) 6633 [(M-H)-], Example M282 (RSVf5-(Methyl-propy1-aminn)-2-(3-oxo-3-l3-[2-ftetrahydro-pvran^ pyridin-4-yl1-phenyll-propionYlaminoV4-1xifluoromethyl-phenyl1^ acid tert- butyl ester The title compound was obtained from [2-amino-5-(methyl-propyl-amino)-4-trifluoromethyl-phen^j-carbamic acid tert-butyl ester (Example J17) (347 mg> 1.0 mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic add tert-butyl ester (Example K40) (412 mg, 1,0 mmol) according to the general procedure M as a light red foam (260 mg, 38%). MS (ISP) 683.4 [(M-H)-]. Example M283 fRSVr5-(Isopropvl-methyl-aminoV2-f3"OXO-3-(3-f2-ftetrahvdro-pvran-2-yloxymethyD-pyridin-4-yl1 -phenyll-propionylaminn) -4-trifluoromethyl-phenyn -carbamic add tert-butyl ester The title compound was obtained from [2-amino-5-(isopropyl-methyl-amino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J41) (347 mg, 1,0 mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic acid tert-butyl ester (Example K40) (412 mg, 1,0 mmol) according to the general procedure M as a li^t yellow foam (520 mg, 76%). MS (ISP) 683.4 [(M-H)-]. ]fa:ample M284 (RS)-f5-(Dimethyl-aminoV2-(3-oxo-3-[3-(2-(tetrahvdro-pvran-2-vloxvmethvD-pyridin-4-yl1-phenyll-propionvlaniino)-4-trifluoromethyl-phenyl1-carbamic add tert-butyl ester The title compound was obtained from [2-anuno-5-(dimethyl-amino)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example Jl) (319 mg, 1.0 mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic acid tert-butyl ester (Example K40) (412 mg, 1.0 mmol) according to the general procedure M as a light red foam (470 mg, 72%). MS (ISP) 655.5 [(M-H)-]. Example M285 (2-{3-r3'(2-Methyl-pyridm-4-yl)-phenyl1-3-oxo*propionylaiiiino trifluoromethyl-phenyl)-carbamic acid tert-butvi ester The title compound was prepared from (2-amino-5-morpholin-4-yl-4-trifluoromethyi-phenyl)-carbamic add tert-butyl ester (Example J28) (271 mg, 0,75 mmol) and 3- [3- (2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (234 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (355 mg, 79%). MS (ISN) 597.2 [(M-H)-]. Example M286 f2-l3-r3-(2.6-Dimethyl-pyridin-4-yl)-phenyl]-3-oxo-'propionylaniinol-5-morpholin-4-yl-4-trifluoromethyl-phen^Vcafbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-morpholin-4-yl-4-trifluoromethyl-phenyl)-carbamic add tert-but)d ester (Example J28) (271 mg, 0.75 mmol) and and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as a li^t yellow foam (387 mg, 84%). MS(ISN)61L2[(M-H)-]. Example M287 f5-Ethoxy-2-B-r3-f2-morphohn-4-yl-pyridin-4-viVphenyl1-3-oxo-propionvlaniinol-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-ethox7-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and and 3-[3-(2-morpholin-4-yl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K62) (286 mg, 0.75 mmol) according to the general procedure M. Obtained as a white solid (259 mg, 55%). MS (ISN) 627.2 [(M-H)-]. Example M288 f2--f3-r3-f2"Morpholin-4-yl-pyridin'4-yl)-phenylV3-oxo-propion^^ lTifluoro-ethoxy')'4'trifluoromethyl-phenyl1"Carbaim add tert-butyl ester The title compound was prepared from [2-ammo-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (!&cample J6) (281 mg, 0.75 mmol) and and 3-[3-(2-morpholin-4-yl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K62) (286 mg, 0 J5 mmol) according to the general procedure M. Obtained as a light brovm foam (433 mg, 85%). MS (ISN) 681.3 [(M-H)-]. Example M289 (5-Methyl-2-{3-[3-(2-morpholin-4-yl-pyridin-4-yl)-phenyl1-3-oxo-propionvlaminol-^ trifluoromethyl-phenylVcaTbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and and 3-[3-(2-morpholin-4-yl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K62) (286 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow foam (393 mg, 88%). MS (ISN) 597.4 [(M-H)']. Example M290 (2-J3-Oxo-3-[3-(2-pyrrohdin-l-yl-p\^din-4-yl)-phenyl1-propionylaminol-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (214 mg, 0.75 mmol) and 3-oxo-3-[3-(2-pyrroUdin-l-yl-pyridin-4-yl)-phenyl]-propionic add tert-butyl ester (Example K63) (275 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white amorphous substance (334 mg, 78%). MS (ISN) 567 [(M-H)1. Example M291 (5-Methyl-2-{3-oxo-3-r3-f2-pvrroU(iin-l-yl-pyridin-4-^VphenAd1-pro^ trifluorometfayl-phenyl)-carbaimc acid tert-butyl ester The title compound was prepared from (2-amino-5-metliyi-4-trifluoromethyl-plienyI)-carbamic acid tert-butyl ester (Example J20) (218 mg, 0.75 mmol) and 3-oxo-3-[3-(2-pyrrolidin-l-yi-pyridin-4-yl)-phenyl]-propionic add tert-butyl ester (Example K63) (275 mg, 0.75 mmol) according to tibe general procedure M* Obtained as an off-white amorphous substance (348 mg, 80%). MS(ISN)581[(M-H)-]. Example M292 f5-Ethoxy-2-^3-oxo-3-[3-(2-pyrroHdin-l-yl-pyridin-4-yl)-phenyl1-propionylain^ trifluoromethyl-phenyl)-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-ethox7-4-trifluorometh)d-phenyl)-carbamic acid tert-butyl ester (Example J8) (240 mg, 0.75 nrniol) and 3-oxo-3- [3-(2-pyrroKdin-l-yl-pyridin-4-yl)-phenyl]-propionic acid tert-butyl ester (Example K63) (275 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow amorphous substance (379 mg, 82%). MS(ISN)611[(M-H)-]. Example M293 r2-{3-Oxo-3-f3-(2-pyrrohdin-l-yl-pyridin-4-yl)-phenyl1-propionylaiiiinol-5-(2^^2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl1-carbamic acid tert-butid ester The title compoxind was prepared from [2-amino-5-(2,2,2-trifluoro-etiioxy)-4-trijfluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-oxo-3-[3-(2-pyrrolidin-l-yl-pyridin-4-yl)-phenyl]-propionic acid tert-butyl ester (Example K63) (275 mg, 0.75 mmol) according to the general procedure M. Obtained as a light yellow amorphous substance (419 mg, 84%). MS (ISN) 665 [(M-H)1. Example M294 r2-f 3" f 231 Bipyridmvl-4-yl-3-oxo-propionvlamino V4-1rifluoromel3iyl^ - carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J3) (214 mg, 0.75 mmol) and 3-[23']bipyridinyl-4-yl"3-oxo-propionic acid tert"but)d ester (Example K57) (224 mg, 0.75 mmol) according to the general procedtire M- Obtained as a yellow foam (268 mg, 71%). MS(ISN)499[(M-H)-]. Example M295 [?.>(^-[7,^']RipyriHinyl-4-yl-3"OXO"propionvlaminoV5-efeoxy-4-trifluorometfayl-phenyl!-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-5-ethoxy-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J8) (240 mg, 0.75 mmol) and 3-[2,3']bipyridinyl-4-yl-3-oxo-propionic add tert-butyl ester (Example K57) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (319 mg, 78%). MS(ISN)543I(M-H)']. Example M296 f2-(3-[23nBipyridinyl-4-yl-3-oxo-propionvlaminoV5-(2.2.2-trifluoro-ethoxy)-4-trifluoromethyl-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[2,3']bipyridinyl-4-yl-3-oxo-propionic add tert-butyl ester (Example K57) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (342 mg, 76%). MS (ISN) 597 [(M-H)'], Eyample M297 (RS)-f4-choro-5-methyl-2-f3-l3-r2-methyl-6-ftetrahydro-pvran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propionylamino)-phenyl]-carbamic acid tert-buryl ester The tide compound was prepared from (2-amino-4-cihloro-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (257 mg, 1.0 mmol) and (RS)-3-{3-[2-methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propioiiic add tert-butyl ester (Example K64) (426 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow foam (460 mg, 76%), # MS (ISP) 608.3 [(M+H)1. Example M298 (RSV(5-Methyl-2-f3-l3-[2-metfayl-6-(tetrafavdro-pyran-2-vloxvmethvIVpy^ phenyl]-3-oxo-propionvlaminoV4-trifiuoromethyl-phenyn-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J20) (290 mg, 1,0 mmol) and (RS)-3-{3- [2-methyl-6-(tetrahydro-pyran-2-}doxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propionicadd tert-butyl ester (Example K64) (426 mg, LO mmol) according to the general procedure M, Obtained as a light yellow foam (510 mg, 79%). MS (ISP) 642.4 [(M+H)1. Example M299 f RS V r5-Chloro-2- (3-13- f 2-methyl-6-f tetrahydro-pvran-2-^oxymeihvlVpyridin-4-yl1 -phenvU-3-oxo-propionylaminoV4-trifluorometfavl-phenyl1-carbamic add tert-butyl ester The title compound was prepared from (2-amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J19) (311 mg, 1.0 mmol) and (RS)-3-{3-[2-methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-3-oxo-propiomcadd tert-butyl ester (Example K64) (426 mg, LO mmol) according to the general procedure M, Obtained as a light ydlow foam (420 mg, 63%). MS (ISP) 662.3 [(M+H)1. Example M300 (RSVr2-(3-{3-[2-MethvI-6-(tetrahydro-pyran-2-vioxymethyl) oxo-propionylammono)-5-(2,2.2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenylj-carbamic acid tert-butyl ester (Example J6) (374 mg, LO mmol) and (RS)-3-{3- [2-meth)d-6-(tetrahydrO"pyran-2-yloxymethyl)-pyridin-4-7l] -phenyl}-3-oxo-propionic acid tert-butyl ester (Example K64) (426 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow foam (500 mg, 69%). MS (ISP) 726.4 [(M+H)1. Example M301 (RSVf5-ethoxy-2-(3-B-[2-methyl-6"ftetrahydro-pvran-2-vloxymethyl)-^ phenyll-S'Oxo-propionylaminoM-trifluorometfavl-phenyll-carbamic add tert-butyl ester The title compound was prepared from [2-aniino-5-ethoxy-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Ejcample J6) (320 mg, 1.0 mmol) and (RS)-3-{3-[2-methyl-6-(tetrahydro-pyran-2-ylox7methyl)-pyridin-4-yl] -phenyl}-3-oxo-propionic acid tert-butyl ester (Example K64) (426 mg> 1.0 mmol) according to the general procedure M. Obtained as a light yellow foam (550 mg, 82%). MS (ISP) 672,4 [(M+H)+]. Example M302 (RS)-f2-f3-l3-[2-Methyl-6-ftetrahydro-pvran-2-vloxvmethvD-pyridin-4-yl1-phe oxo-propionylaminoV4-trifluoromethyl-phenvn-carbamic acid tert-butyl ester The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) (276 mg, 1.0 mmol) and (RS)-3-{3-[2-methyl-6-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-ph€nyl}-3-oxo-propionic acid tert-butyl ester (Example K64) (426 mg, 1.0 mmol) according to the general procedure M. Obtained as a light yellow foam (470 mg, 75%). MS (ISP) 628.4 [(M+H)1. Example M303 [2-{3-[3- f 3-(2,6-I)imethyl-pyridin-4-yl)-phenyl1 -3-oxo-propionylaminol-5-f isobutyl-methyl-amino)-4-trifluoromethyl-phenyl-carbam acid tert-butyl ester The titie compound was obtained from [2-amino-5-(isobut7l-methyl-amino)-4-trifluoromethyl-phenyl]-carbandc add tert-butyl ester (Example J40) (361 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M as an off-white solid (380 mg, 62%). MS (ISP) 611.4 [(M-H)1; mp 175 °C. Example M304 (S-Dimethylamino-2-{3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo propionylamino}-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester The title compound was obtained from [2-amino-5-dimethylamino-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example Jl) (319 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M as a li^t brown solid (390 mg, 68%). MS (ISP) 569.4 [(M-H)-]; mp 145 °C. Example M3Q5 [4-Chloro-2-{3-[3-(2.6-dimethyl-pyridm-4-yl)-phenyl1-3-oxo-propionylaminol-5-(isobutyl-methyl-aminoVphenyn-carbamic add tert-butyl ester The title compound was obtained from (2-amino-4-chloro-5-(isobutyl-methyl-amino)-l" phenyl)-carbamic add tert-butyl ester (Example J42) (328 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin"4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M as a light yellow solid (440 mg, 76%). MS (ISP) 579.6 [(M+H)+]; mp 95 °C Example M306 (2-l3-[3-(2,6-Dimethyl-pyridin-4-yl)-phenvi1-3-oxo-propionylamino}-5-pyrrolidin-1 vl-4-trifluoromethyl-phenyl-carbamic add tert-butyl ester RO4598802-000 The title compound was obtained from (2-amino-5-pyrrolidine- l-yl-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example J27) (345 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M as a yellow solid (470 mg, 79%). MS (ISP) 597.4 [(M+H)+]; mp 161°C Example M307 f2-{3-[3-(2.6-Dimethyl-pyridin-4-yl)-phenyl1-3-oxo-propionylaminol-5-fisopropyl* methyl-aminoV4-trifluoromethyl-pheny[1-carbamic add tert-butyl ester The title compound was obtained from l2-amino-5-(isopropyl-methyl-amino)-4-trifluoromethyl-phenyl]-carbamic add tert-butyl ester (Example J41) (347 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridm-4-yl)-phenyll-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M as a light brown solid (440 mg, 73%). MS (ISP) 599.4 [(M+H)+]; mp 187 °C, Example M308 [2-{3-[3-(2.6-Dimethyl-pyridin-4-yl-phenyll-3-oxo-propionylaminol-5-(methyl-propyl-amino)-4-trifluorometfayl-phenyn-carbamic add tert-butyl ester The title compound was obtained from [2-amino-5-(methyl-propyl-amino)-4-trifluoromethyl-phenyl]-carbamic add tot-butyl ester (Example J17) (347 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic add tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M as a light brown solid (420 mg, 70%). MS (ISP) 599.4 [(M+H)+]; mp 123 °C Example 1 7.8-Dichoro-4-(3-pyridin-3-yl-phenyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one The title compound was prepared from 4,5-diclilorophenylenediamine (172 mg, 0.97 mimol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester (Example Kl) (289 mg, 0,97 mmol) by refluxing in xylene according to the general procedure M. Obtained as an off-white solid (310 mg). MS (ISP) 382,2 [(M+H)'], 384 [(M+2+H)+] and 386 [(M+4+H)+']; mp 241 °C. Esample2 7.8-Dichloro-4-f3-pyridin-4-yl-phenyl)-l,3-dihydro-benzorb1 [1.41 diazepin-2-one The title compound was prepared from 4,5-dichlorophenylenediamine (177 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-4-yl-phenyl)-propionic add tert-butyl ester (Example K2) (297 mg, 1.0 mmol) by refluxing in xylene according to the general procedure M. Obtained as a brown solid (269 mg). MS (ISP) 382.2 [(M+H)+], 384 [(M+2+H)+] and386 [(M+4+H)+]; mp 240 °C, Examples . 7-Dimethylamino-4-f3-pyridin-3-yl-phenyl)-8-trifluoromethyl-13-dihydro-benzo [b] [1,4] diazepin-2-one The title compound was prepared from {5-dimethylamino-2-[3"OXO-3-(3-pyridin-3-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic add tert-butyl ester (Example Ml) (306 mg, 0.56 mmol) by treatment with TEA in CH2CI2 according to the general procedure N. Obtained as a yellow solid (162 mg). MS (ISP) 425.4 [(M+H)+]; mp 204 X, Example 4 7-Dimethylamino-4-f3"pyridin-4-yl-phenyl)"8-trifluoromethyl-1.3--dihydro-benzofbl [l,4ldiazepin-2-one Prepared from {5-dimethylaminO"2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M2) (284 mg, 0.52 mmol) by treatment with TEA in CH2CI2 according to the general procedure N. Obtained as a yellow solid (158 mg). MS (ISP) 425.4 [(M+H)+]; mp 202 °C. Examples 7,8-Dichloro-4-(3-pyridin-2-l-phenyl)-1,3-dihydro-benzo[b][1,4] diazepin-2-one The title compound was obtained from 4,5-dichlorophenylenediamine (177 mg, 1.0 ' mmol) and 3-oxo-3-(3-pyridin-2-yl-phenyl)-propionic acid tert-butyl ester (Example K3) (297 mg, 1.0 mmol) by refluxing in xjdene according to the general procedure M as a pink solid (260 mg), MS (ISP) 382.3 [(M+H)+], 384 [(M+2+H)+l and 386 [(M+4+H)+]; mp 239 °C Example 6 7-Dimethylamino-4-(3-pyridin-2-yl-phenyl)-8-trifluoromethmethyl-1,3-dihydro-benzo[b][1,4]diazepin-2'One The title compound was prepared from {5-dimethylamino-2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acidtert-butyl ester (Example M3) (253 mg, 0.466 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (66 mg). MS (ISP) 425.5 [(M+H)+]; mp 201 °C. Example 7 8-Fluoro-4-(3-pyridin-3-yl-phenylVl3-dihydro-benzorb1[1.4ldiazepin-2-one The title compound was prepared from {4-fluoro-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic add tert-butyl ester (Example M4) (94 mg, 0.21 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (55 mg). MS (ISP) 332 [(M+H)+]; mp 210 °C. Examples > 8-Huoro-4-(3-pyridin-4-yl-phenyD-1.3-dihydro-benzorbirL4ldiazepin-2-one The title compound was prepared from {4-fluoro-2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-phenyl}-carbamic acidtert-butyl ester (Example M5) (245 mg, 0.75 mmol) by treatment with TFA in CH2CI2 according to the general procedure N, Obtained as a light brown solid (145 mg). 8-(2-Fluoro-phenyl)-4--[3-(6--method-pyridin-3-yl-phenyll-13-dihydro-benzoFb] f 1.41 (iiazepm-2-one The title compound was prepared from (2'-fluoro-3-{3-[3-(6-methyl-pyridin-3yl)-phenyl]-3-oxo-propionylamino}"biphenyl-4-yl)-carbamic add tert-butyl ester (Example M9) (340 mg, 0.63 mmol) by treatment with TFA in CH2CI2 according to the general procedure N- Obtained as a yellow solid (201 mg). MS (ISP) 4223 [(M+H)+]; mp 206-209 °C. Example 13 7-Dimethylamino-4-[3-f2-methyl-pyridin-3-^Vphenyl1-8-trifluoromethyl-L3-dT}iyd benzofb] [1,41 diazepin-2*one The title compound was prepared from (5-dimethylamino-2-{3-[3-(2-meth}^-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example MIO) (380 mg, 0.683 mmol) by treatment with TFA in CH2CI2 according to the general procedxure N. Obtained as a light yellow solid (215 mg). MS (ISP) 439.4 [(M+H)+]; mp 229-230 °C 4-[3-f6-Methyl-pyridazin-3-yD-phenyll-8"trifluoromethvI-13-dihydro-benzofbUl.4ldiazepin-2-one The title compound was obtained from (2-{3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionylamino}'4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example Mil) (286 mg, 0.56 mmol) by treatment with TFA in CH2CI2 according to the general procedure N as a light yellow solid (176 mg). MS (ISP) 397 [(M-i-H)+]; mp 233 °C Example 15 7-Dimethylamino-4-[3-(6-metfavl-pyridazin-3-yl-phenylnvn-8-trifluoromethyM3-dihydro-benzofbl ri.4ldiazepin-2-one The title compound was pr^ared from (5-dimethylamino-2-{3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionyianaino}-4-trifluoromethyl-phenyl)-carbamic add tert- butyl ester (Example M12) (301 mg, 0.54 mmol) by treatment with TFA in CH2CI2 according to the general procedure N, Obtained as a light yellow solid (189 mg), MS (ISP) 440 [(M+H)+]; mp 174 °C Esample 16 8-f2-Fluoro-phenyl-4"[3-(6-methyl-pyridazin-3-ylVphenyl1-13-dihydro-benzofb] [1.4ldiazepin-2-one The title compound was prepared from (2'-fiuoro-3-{3-[3-(6-methyl-pyrida2in-3-yl)-phenyl3-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic add tert-butyl ester (Example M13) (292 mg, 0.541 mmol) by treatment with TFA in CH2a2 according to the general procedure N. Obtained as a light yellow solid (181 mg). MS (ISP) 423 [(M+H)+]; mp 225°C Example 17 4-[3-(2-Methyl-pyridin-3-yl)-phenyl]-8-trifluoromethyl-1,3-dihydro-benzofbl f 1.4ldiazepin-2-one The title compound was prepared from (2-{3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example M14) (280 mg, 0.545 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a pink solid (163 mg). MS (ISP) 396.3 [(M+H)1; mp 219-220 °C. Example 18 8-Fluoro-4- [3-(2-methyl-pyridin-3-yl-phenvn-13-dihydro-benzo [b] [ 1,41 diazepin-2-one The title compound was prepared from (4-fluoro-2-{3-[3-(2-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic add tert-butyl ester (Example M15) (250 mg, 0.539 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (143 mg). MS (ISP) 346.4 [(M+H)1; mp 219-220 '°C 8-(2-Fluoro-phenyl)-4-[3-(2-methyl-pyridin-3-yl)-phenyl1-13-dihydro benzo[b][1,4] diazepin-l-one The title compound was prepared from (2'-fluoro-3-{3-[3-{2-me1iiyl-pyridin-3-yl)" phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic add text-butyl ester (Example M16) (330 mg, 0.611 mmol) by treatment with TFA in CH2Q2 according to the general procedure N. Obtained as a light yellow solid (211 mg). MS (ISP) 422.4 [(M+H)1; mp 192-194°C Example 20 4-(3-Pyridin-4-^-phenylV8-trifluoromethYl-l^-Vdihydro-benzo[biri,4]dm The title compound was prepared from {2-[3"OXO-3-(3-pyridin"4-yl-phenyl)-propionylamino]-4-trifluorometibyl-phenyl}-carbainicacidtert-butyl ester (Example M17) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a white solid (176 mg). MS(ISP)382[(M+H)+]. Example 21 8-(2-Fluoro-phenyl)-4-(3-pyridin-4-yl-phenyl)-l3-dihydro-benzorbiri.4ldiazepin-2- one The titie compound was prepared from {2'-fluoro-3-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester (Example M18) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (237 mg). MS(ISP)408[(M+H)1. Example 22 8-Chloro-4'f3-pyridin-4-yl-phenyD-1.5-dihydro-ben2X3rb1[L4ldia2epin-2-one The title compound was obtained from {4-chloro-2"[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-phenyl}-carbamic add tert-butyl ester (Example M19) by treatment with TFA in CH2CI2 according to the general procedure N as a light brown solid (61 mg). MS (ISP) 348 [(M+H)+] and 350 [(M+2+H)']; mp 225-226 °C. Example 23 8-choro-7-fluoro-4-[3-(6-methyl-pyridin-3-yl-phenylnyll-1,3-dihydro-benzo[b]b[1,4]ldiazepin-2-one The title compound was prepared from (4-chloro-5-fluoro-2-{3-[3-(6-methyl-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester (Example M20) (241 mg, 0-48 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as an off-white solid (124 mg). MS (ISP) 380.3 [(M+H^] and 382 [(M+2+H)1; mp 215-220 °C. Example 24 8-choro-7-fluoro*4-(3-pyridin-4-yl-phenylVl3-dihydro-benzofb1fl.4ldiazepin-2'One The title compound was prepared from {4-chloro-5-fiuorO"2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-phenyl}-carbamic add tert-butyl ester (Example M21) (239 mg, 0.49 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as an off-white solid (149 mg). MS (ISP) 366-2 [(M+H)+] and 368 [(M+2+H)']; mp 235-240 °C. Example 25 8-Methyl-4-(3-pyridin-3-vl-phenyD-7-trifluoromethyl-l,3-dihydro-benzo fb] f 1.41 diazepin-2-one The title compound was prepared from {4-methyl-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-5-trifluoromethyl-phenyl}-carbamic add tert-butyl ester (Example M22) by treatment with TFA in CH2Q2 according to the general procedure N. Obtained as a white solid (162 mg). MS (ISP) 396 [(M+H)+]; mp 221 '°C. Example 26 8-choro-7-methyl-4-(3-pyridin-3-vl-phenyl)-l3-dihydro-benzorb1fl.4ldiazepin-2-one The tide compound was obtained from {4-chloro-5-methyl-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester (Example M23) by treatment with TFA in CH2CI2 according to the general procedure N as a light yellow solid (155 mg). tert-butyl ester (Example M27) by treatment with TFA in CH2CI2 according to the general procedure N, Obtained as a white solid (173 mg). MS (ISP) 480 [(M+H+]; mp 217°C V Example 31 8-choro-4-[3-(6-metfayl-pyridin-3-yl)-phenyl1-1,3-dihydro-benzor[b][1,4]diazepin-2- one The tide compound was prepared from (4-chloro-2-{3-[3-(6-methyl-pyridin-3-yi)-phenyl]-3-oxo-propion3damino}-phenyl)-carbamic add tert-butyl ester (Example M28) (282 mg, 0.59 mmol) by treatment with TEA in CH2Q2 according to the general procedure N. Obtaixied as a light brown solid (163 mg). MS (ISP) 362 [(M+H)+] and 364 [(M+2+H)1; mp 230 °C. Example 32 8-Chloro-4"f3-(2-methyl-pyridin-3-ylVpheriy11-Ti^-dihydrn-benzofbirL4ldiazep^^ one The title compound was prepared from (4-chloro-2-{3-[3-(2-methyl-pyridin-3-yl)" phenyl] *3-oxo-propionylamino}-phenyl)-carbamic add tert-butyl ester (Example M29) (216 mg, 0.45 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light brown solid (121 mg). MS (ISP) 362 [(M-hH)+] and 364 [(M+2+H)+]; mp 198 °C Eiample 33 4- f 3-Pyridin-2-yl-phen-\d V8-trifluoromethyl" L3-dihydro-benzo fbl [ 1.41 diazepin-2-one The title compound was prepared from {2"[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethyl-phen}i}-carbamic add tert-butyl ester (Example M30) (275 mg, 0.551 mmol) by treatment with TFA in CH2CI2 according to the general procedxire N. Obtained as a white solid (141 mg). MS (ISP) 382.3 [(M+H)+]; mp 226-227 '°C. 4-(3-Pyridin-3-vl-phenyl)-l,3-dihydro-benzon[b][1,4]diazepin -2-one The title compound was prepared from 1,2-phenylenediainine (81 mg, 0.75 mmol) and 3-oxo-3-(3-pyridin"3-yl-phenyl)-propionic acid tert-butyl ester (Example Kl) (223 mg, 075 mmol) by refuxing in xylene according to the general procedure M. Obtained as a white solid (204 mg). MS (ISP) 314 [(M+H)+]; mp 210-211 °C Example 35 7-Methoxy-4-(3-pyridin-4-yl'phenyl)8-trifluorometfa'vd-1.3-dihydro-benzo[b][1,4] diazepin-2-one The tille compound was prepared from {5-methoxy-2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M31) by treatment with TFA in CH2Q2 according to the general procedure N. Obtained as a light yellow solid (183 mg). MS (ISP) 412.3 [(M+H)+]; mp 225 °C (dec). Example 36 7-ethoxy-4-(3-pyridin-4-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one The title compound was prepared from {5-ethoxy-2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic add tert-butyl ester (Example M32) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (184 mg). MS (ISP) 426.4 [(M+H)+]; mp 206-207 °C (dec). Example 37 4-(3-pyridin-4-yl-phenyl)-7-(2.2.2-trifluoro-ethoxy)-8-trifluQromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one The title compound was prepared from [2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamicadd tert-butyl ester (Example M33) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (175 mg). MS (ISP) 480,3 [(M+H)+]; mp 221-222 X (dec). Example 38 8-Methoxy-4-(3-pyridin-4-yl-phenyl)l3-dihydro-benzo[b][1,4]diazepin-2-one The title compound was prepared from {4-methox7-2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester (Example M34) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid(160mg). MS (ISP) 344.4 [(M+H)-*-]; mp 193-196 °C Example 39 7-Dimethylamino-8- f 2-fluoro-phenyl V4- (3-pyridin-4-yl-phenyl)- 13-dihydro-benzofbl f 1.4ldiazepin-2-one The title compound was prepared from {2-dimethylamino-2*-fluoro-5-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic add tert-butyl ester (Example M35) (302 mg, 0.531 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a yellow solid (208 mg). MS (ISP) 451.4 [(M+H)+]; mp 236-237 °C. Example 40 7-Dimethylamino-4-(3-f6-methoxy'-pyridazin-3-yl)-phenyl1-8-trifIuoromethyl-1,3-dihydro-benzofbl [1.4ldiazepin-2-one The title compound was prepared from (5-dimethylamino-2-{3-[3-(6-methoxy-pyridazin-3-yl)-phenyl]-3-oxcKpropionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M36) (282 mg, 0.49 mmol) by treatment with TFA in CH2CI2 according to the general procedure N, Obtained as an off-white solid (214 mg). MS (ISP) 456 [(M+H)+*]; mp 224°C Example 41 8-(2-Fluoro-phenyl)-4-[3-(6-methoxy-pyridazin-3-yl]-phenyl]-1,3-benzor[b][1,4]diazepin-2-one The title compound was prqpared from (2'-fluoro-3-{3-[3-(6-metiioxy-pyridazin-3-yi)-phenyl]-3-oxo-propionylamino}-biplieiiyl-4-yl)-carbamic acid tert-butji ester (Example M37) (308 mg, 0.55 mmol) by treatment with TEA in CHaQa according to the general procedm-e N- Obtained as a light yellow solid (178 mg). MS (ISP) 439 [(M+H)+]; mp 220 °C Example 42 7-Methoxy-4-(3-pyridin-2-yl-phenyl)8-trifluQrometby1-T^Vdi]iydro-benzo[b][1,4]dia2epin-2-one The title compound was prepared from {5-methoxy-2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic add tert-butyl ester (Example M38) (208 mg, 0.39 mmol) by treatment with TEA in CH2CI2 according to the general procedure N. Obtained as an off-white solid (140 mg). MS (ISN) 410 [(M-H)-]; mp 240 °C Example 43 7-ethoxy-4-(3-pyridin-2-yl-phenyl')-8-trifluoromethyl-1,3-dihydro-benzo [b][1,4] diazepin-2-one The title compound was prepared from {5-ethox7-2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic add tert-butyl ester (Example M39) (198 mg, 0.36 mmol) by treatment with TEA in CH2a2 according to the general procedure N. Obtained as an off-white solid (138 mg), MS (ISN) 424 [(M-H)-]; mp 229 °C Example 44 4-(3-pyridin-2-yl-phenyl-7-(2.2,2-trifIuoro-ethoxy)-8-trifluoromethyl-1,3-dihydro-benzo [b][1,4] diazepin-2-one The title compound was prepared from [2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M40) (165 mg, 0.36 mmol) by treatment "with TFA in CH2O2 according to the general procedure N. Obtained as an off-white solid (81 mg). MS (ISN) 478 [(M-H)']; mp 214 °C Example 45 8-choro-7-methyl-4-(3-pyridin-2-yl-phenyl)l3-dihvdrQ-benzon[b][1,4]diazepin'2-one The title compound was prepared from {4-chloro-5-methyl-2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-phenyl}-carbamic add tert-butyl ester (Example M41) (269 mg, 0.561 mmol) by treatment with TFA in CH2Q2 according to the general procedure N. Obtained as a white solid (161 mg). MS (ISN) 360.1 [(M-H)-] and 362 I(M+2-H)"]; mp 222 X (dec). Example 46 7"Methyl-4" (3-pyridin-2-yl-phenyl V8-trifluoromethyl-1 ^3-diliydrn-benzofbl f l,4ldiazepin-2-one The tide compound was prepared from {5-methyl-2-[3-oxO"3-(3-pyridin-2-yl-phenyl)-propionyiamino]-4-trifluoromethyl-phenyl}-carbamic add tert-butyl ester (Example M42) (245 mg, 0.476 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (162 mg). MS (ISN) 394-2 [(M-H)-]; mp 251-253 °C Example 47 7-Dimethylamino-4- f 3-f 2^6-dimethyl-pyridiTi-^-Yl)-phenyl1 -8-trifluoromethyl-1,3-dihydro-benzorbl[1.4ldia2epin-2-one The title compound was prepared from (5-dimethylamino-2-{3-[3-(2,6-dimethyl-pyridin-3-yl)-phenyl] -3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic add tert-butyl ester (Example M43) (190 mg, 0.333 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a brown solid (97 mg). MS (ISP) 453.5 [(M+H)+]; mp 187-189°C 8-CMoro-7-methyl-4-(3-pyridazin-4-yl-phenyl)l3-dihydro-benzo[b][1,4]diazepin-2-one The title compound was prepared from {4-chlorO"5-methyl-2-[3-oxo-3-(3-pyridazin-4-3d-phenyl)-propion)iamino]-phenyl}-carbainic acid tert-butyl ester (Example M44) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a white solid (59 mg), MS (ISP) 363 [(M+H)+] and 365 [(M+Z+H)+]; mp 240 °C (dec.)- Example 49 7-Methyl-4-(3-pyridazin-4-yl-'phenyl)8-trifluoromethyl-l,3-dihydro-benzo fbl f 1,41 diazepin-2-one The title compotind was prepared from {5-meth)d-2-[3-oxo-3-(3-pyrida2in-4-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M45) by treatment with TFA in CH2CI2 according to the general procedm-e N. Obtained as a white solid (110 mg). MS (ISP) 397 [(M+H)+]; mp 223 °C Example 50 4* f 3-(6-Methoxy-pyridin-3-yl)-phenyl1 -8-trifluoromethyl-1.3-dihydro-benzofbl f 1,41 diazepin-2-one The title compound was prepared from (4-chloro-2-{3-[3-(6-methoxy-pyridin-3-yl)-phenyl]-3-oxo-propionyiamino}-phenyl)-carbamic add tert-butyl ester (Example M46) (270 mg, 0.54 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as an off-white solid (79 mg). MS (ISP) 412 [(M+H)'*']; mp 210-215°C Example 51 8-choro-4-(3-(6-methoxy-pyridin-3-yl-phenylnyll-1,3-dihydrn>benzofbiri4ldia2epi one The title compound was prepared from (4-chloro-2-{3-[3-(6-methox7-pyridin-3-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester (Example M47) (270 mg, 0.54 mmol) by treatment -with TFA in CH2Q2 according to the general procedure N. Obtained as an off-white solid (129 mg). MS (ISP) 378 [(M+H)+] and 380 [(M+2+H+]; mp 200-205°C Example 52 8-choro-7-fiuoro-4-(3-pyridin-2-yl-phenYl)-1,3-dihydro-benzo [b] [1,4]diazepin-2-one The title compound was prepared from {4-chloro-5-fluoro-2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-phenyl}-carbamic add tert-butyl ester (Example M48) (270 mg, 0,54 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light brown solid (174 mg). MS (ISP) 366 [(M+H)+"] and 368 [(M+2+H)+]; mp 197-198 °C Example 53 8-(2-Fluoro-phenyl)4-(3-pyridin-2-yl-phenyl)-1,3-dihydro-benzorb[b] [1,4]diazepin-2-one The title compound was prepared from {2'-fluoro-3-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic add tert-butyl ester (Example M49) (350 mg, 0.66 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (153 mg). MS(ISP)408[(M+H)+]. Example 54 4-(3-Pyridin-2-yl-phenyl)-8-pyrrol* 1-yl- 1.3-dihydro-benzo fb] [1,41 dia2epin-2-one The title compound was prepared from {2-[3-oxo-3-(3-pyridin-2-yl-phenyl)" propionylamino]-4-pyrrol-l-yl-phenyl}-carbamic add tert-butyl ester (Example M50) (290 mg, 0*58 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow soKd (73 mg). MS(ISP)379[(M+H)+]. P.Tfl-mple f>-S 7-Met3iQxy-4" f S-pyridin-^-yl-phen^ V 13-dihydrn-benzo [b1 [ 1,41 diazepin-2-one The title compound was prepared from {5-methoxy-2-[3-oxo-3-(3-pyridin-3-3d-phenyl)-propionyiamino]-phenyl}-carbamic add tert-butyl ester (E3ample M51) (229 mg, 0.50 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light brown solid (159 mg). MS (ISP) 344.4 [(M+H)1; mp 219 °C (dec). Example 56 4-(3-Pyridin-2-yl-phenyl)-7-(2,2.2-trifluoro-ethoxy)-l3-dihydro-benzo[b] [1,4]diazepin-2-one The title compound was prepared from [2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-5-(2>2,2-trifluoro-ethoxy)-phen^]-carbamic add tert-butyl ester (Example M52) (380 mg, 0.72 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a white solid (201 mg). MS(ISP)412[(M+H)+]. Example 57 4-(3-pyridin-3-vl-phenyl)-7-(2.2,2-trifluoro-ethoxy)-l,3-dihydro-benzo f b] [ 1.41 diazepin-2-one The title compound was prepared from [2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-5-(2,2,2-trifluoro-ethoxy)-phenyl]-carbamic add tert-butyl ester (Example M53) (356 mg, 0,67 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (190 mg). MS(ISP)412[(M-hH)1. Example 58 4-(3-pyridin-4-yl-phenyl-7-(2,2,2-trifluoro-ethoxy)-l3-dihydro-benzo f b1 [ 1.4] diazepin-2-one The title compound was prepared from [2-[3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-5-(2,2,2-trifluoro-ethox7)-phenyl]-carbamic add tert-butyl ester (Example M54) (250 mg, 0.47 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as a light yellow solid (80 mg). MS(ISP)412[(M+Hf]. 7-Ethoxy-4-[3-3-(2-methyl-pyridin-4-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2 one The title compound was prepared from (5-ethoxy-2-{3- [3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester (Example M55) (213 mg, 0.44 mmol) by treatment with TFA in CH2Q2 according to the general procedure N. Obtained as a yellow solid (120 mg). MS (ISP) 372 [(M+H)+]; mp 163°C F.Yatnple dO 7-Ethoxy-4-[3-f6-methyl-pyridin-3'ylVphenyl]-l,3-dihydro--benzo[b1[1.4ldiazepin-2-one Prepared from (5-ethoxy-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propion)iamino}-phenyl)"Carbamic acid tert-butyl ester (Example M56) (180 mg> 0.37 mmol) by treatment with TFA in CH2CI2 according to tih^e general procedure N. Obtained as a yellow solid (85 mg). MS (ISP) 372 [(M+H)1; mp 173 °C. Example 61 7-ethoxy-4-(3-f2-methyl-pyridin-4-yl)-phenyl1-8-trifluoromethyl-1.3-dihydro-benzofb] |"1.4]dia2epin-2-one The title compound was prepared from (5-ethoxy-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M57) (318 mg, 0.57 mmol) by treatment with TFA in CH2CI2 according to the general procedure N. Obtained as an off-white solid (216 mg). MS (ISP) 440 [(M+H)+]; mp 236°C Claims 1. Compounds of general formula wherein X is a single bond or an ethynediyl group; and wherein in case X is a single bond, R1 is hydrogen, cyano, halogen, lower alkyl, lower alkoxy, fiuoro-lower alkyl, fluoro-lower alkoxy, pyrrol-1-yl, or phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl; or in case X is an ethynedyl group, R1 is phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl; and wherein R is hydrogen, lower alkyl, lower alkenyl lower alkoxy, halogen, -NR'R", pyrrolidin-l-yl. piperidin-1-yl, morpholine-4-yl, fiuoro-lower alkyl, fluoro-lower alkoxy, or lower alkox7-(ethoxy)m. m is 1,2,3 or 4; R' is hydrogen, lower alkyl or Cs-Ce-qrdoalkyl; R" is hydrogen, lower alkjd or Cs-Q-cydoalkyl; Y is-CH=or=N-; R3 is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide, which rings are unsubstituted or substituted by one or two substituents sdected from the group consisting of halogen, fiuoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylanaino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, -(CH2)n-C(0)-0R", -(CH2)n-C(0)-NR'R", -(CH2)n-S02-NR'R", -(CH2)n-C(NH2)=NR", hydroxy, lower alkoxjr, lower alkylthio, C3-C6-cydoalkyl and lower alkyl, whidi is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrolidin-1-yl, azetidin-1-yl, cyano or cafbamoyloxy, whereby R' and R" have the meaning specified above; n is 0,1,2,3 or 4; and their pharmaceutically acceptable addition salts, 2. Compounds of formula I according to daim 1, wherein X is a single bond or an ethynediyl group; and wherein in case X is a single bond, R1 is hydrogen, cyano, halogen, lower alkyl, lower alkoxy, fiuoro-lower alkyl, fluoro-lower alkoxy. pyrrol-1-yl, or phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl; or in case X is an ethynediyl group, R1 is phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl; and wherein R is hydrogen, lower alkyl, lower alkoxy, halogen, -NR'R", pyrrolidin-1-yl, piperidin-1-yl, morpholine-4-yl, fluoro-lower alkyl, fluoro-lower alkoxy, or lower alkoxy-(ethoxy)in; m is 1,2,3 or 4; R' is hydrogen, lower alkyl or C3-C6-cydoalkyl; R" is hydrogen, lower alkyl or C3-C6-cydoalkyl; Y is-CH=or=N-; R is a six-membered aromatic heterocyde containing 1 to 3 nitrogen atoms, which is unsubstituted or substituted by one or two substituents sdected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, -(CH2)n-C(0)-OR", -(CH2)n-C(0)-NR'R", -(CH2)n-S02-NR'R", -(CH2)n-C(NH2)=NR", hydroxy, lower alkoxy, lower alkylthio, C3-C6-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, cyano or carbamoyloxy; whereby R' and R" have the meaning specified above; n is 0,1,2,3 or 4; and their pharmaceutically acceptable addition salts. 3. Compounds according to daim 1 or 2, wherein X is a single bond 4. Compounds according to claim 3, wherein Y is -CH=. 5. Compounds according to claim 4, wherein R3 is pyridyl, which is unsubstituted or substituted by one or two substituents sdected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, -(CH2)n-C(0)-0R", -(CH2)n-C(0)-NR'R", -(CH2)n"S02-NR'R", -(CH2)n-C(NH2)=NR", hydroxy, lower alkoxy, lower alkyltibio, Ca-Q-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrolidin-1-yl, azetidin-1-yl, cyano or carbamoyloxy, and R' and R" are independently from each other selected from hydrogen, lower alkyl or C3-C6-cydoalkyL 6. Compounds according to claim 5, wherein R^ is hydrogen, halogen or lower alkyl or fluoro-lower alkyl. 7. Compounds according to claim 6, wherein R1 is hydrogen or lower alkyl. 8. A compound according to claim. 7, which compound is selected from the group consisting of 8-methyl-4-(3-pyridin-3-yl-phenyi)-7-trifluoromethyl-l,3-dihydro- benzo[b] [l,4]diazepin-2-one, 8-methyl-4- [3-(2-methyl-pyridin-4-yl)-phenyl] -7-trifluoromethyi-l,3-dihydro benzo[b] [ 1,4] diazepin-2-one, 4-(3-pyridin-3-yl-phenyl)-7-{2,2>2-trifluoro-ethoxy)-l,3-dihydro-benzo[b] [l,4]diazepin-2-one, and 4-[3-(2,6-dimeth)4-pyridin-4-yl)-phenyl]"8-methyl-7-trifluoromethyl-l,3-dihydro benzo[b] [l,4]dia2epin-2-one. 9. Compounds according to daim 6, wherein R^ is halogen. 10. A compound according to daim 9, which compound is selected from the group consisting of 7,8-dichloro-4-(3-pyridin-3-yl-phenyl)-13-dihydro-benzo[b]Il,4]diazepin-2-one, . 8-diloro-4- (3-pyridin-4-yl-phenyl)- 13-dihydro-benzo [b] [1,4] diazepin-2-one, 7,8-didiloro-4-(3-pyridin-4-yl-phenyl)-l,3-dihydro-benzo[b][l,4]dia2epia-2-one, 8-chloro-7-methyl-4- (3-pyridin-3-yl-phenyl)- 1,3-dihydro-benzo [b] [ 1,4] diazepin-2-one, 8-chloro-4-(3-pyridin-3-yl-phenyl)-l,3-dihydro-benzo[b] [1,4] diazepin-2-one, 8-chloro-4-[3-(6-methyl-pyridin-3-yl)"phenyl]-l,3-dihydro-benzo[b][l,4]diazepin-2-one. 8-chIoro-4-[3-(2-methyl-pyridin-3-yl)-phen7l]-l,3-dihydro-benzo[b][l,4]diazepin--2-one, 8-chloro-7-methyl-4-(3-pyridin-4-yl-phenyl)-l,3-dihydro-benzo[b][l,4]diazepin-2-one, 7,8-dicloro-4-[3-(2-methyI-pyridm-4-yl)-phenyI]-l,3-dihydro-benzo[b][l>4]diazepin- 2-one, 8-chloro-7-methyl-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-l,3-dihydro- benzo[b][l,4]diazepin-2-one, 8-fluoro-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-l,3-dihydro-benzo[b](l,4]diazepin-2- one, 8-chIoro-4-[3-(2-methyI-pyridin-4-yl)-phenyI]-7-trifluoromethyl-l,3-dihydro benzo[b][l,4]diazepin-2-one, 8-chloro-4-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-7-methyl-l,3--dihydro-- benzo[b][l,4]diazepin-2-one, and 7>8-dichloro-4-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl|-13-dihydro- benzo [b] [ 1 >4] diazepin-2-one. 11. Compounds according to claim 6> wherein R1 is trifluoromethyl. 12. A compound according to claim 11, which compound is selected from the group consisting of 7-dimethylamino-4-(3-pyridin-3-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo[b] [l,4]diazepin-2-one, 7-dimethylamino-4-(3-pyTidin-4-yl-phenyI)-8-trifluoromethyl-l,3-dihydro-benzo[b] [ l>4]diazepin-2-one, 4-(3-pyridin-4-yl-phenyl)-8-triflu'oromethyl-l,3-dihydro-benzo[b][l,4]diazepin-2-one, 4-(3-pyridin-3-yl-phenyI)-7-(2,2,2'-trifluoro-ethoxy)-8-trifluoromethyl-l,3-dihydro-ben2o[b] [ l,4]diazepin-2-one, 7-ethoxy-4'(3-pyridin-4-yl-phenyl)-8-trifluoromethyl-13-dihydro- benzo[b] [l,4]dia2epin-2-one, 4-(3-pyridin-4-yl-phenyl)-7-(2,2,2-trifluoro-ethoxy)-8-trifluoromethyl-13-dihydro-benzo [b] [ 1 >4] diazepin-2-one, 7-methyl-4-(3-pyridin-4-yl-phenyI)-8-tri£lloromethyI-I,3-dihydro-benzo[b] [ l>4}diazepin-2-one, 8-methyl-4-(3-pyridin-4-yl-phenyl)-7-trifluoromethyl-13-dihydro- benzo[b][l,4]diazepin-2-one, 7-chloro-4-(3-pyridin-4-yl-phenyl)-8-trifluoromethyl-l,3-dihydro- benzo[b][l,4]diazepin-2-one, 4-(3-pyridin-3-yi-phenyI)-8-trifluoromethyl-1,3-dihydroxy-beno[b][l,4]diazepin-2-one, 7-ethoxy-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-8-trifluoromethyl-l,3-dihydrobenzo [b] [ 1,4] diazepin-l-one, Compounds according to claim 5, wherein R1 is pyrrol-1-yl or phenyl, which is unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, lower alkyl or fluoro-lower alkyl. 14. A compound according to claim 13, which compound is selected from the group consisting of 8-(2-fluoro-phenyl)-4-[3-(2-methyl-pyridin-3-yl)-phenyl]"l,3-dihydro- benzo [b] [1,4] diazepin-2-one, 8-(2-fluoro-phenyl)-4-(3-pyridin-4-yl-phenyl)-l,3-dihydro-benzo[b][l,4]diazepin-2- one, 8-(2-fluoro-phenyl)-4-(3-pyridin-3-yl-phenyl)-13-dihydro-benzo[b][l,4]diazepin-2- one, and 8-(2-fluoro-phenyi)-4- [3-(2-methyl-pyridin-4-yl)-phenyl] -1,3-dihydro- benzo[b] [l,4]diazepin-2-one. 15. Compounds according to daim 5, wherein R1 is fluoro-lower alkoxy. 16. A compound according to daim 15, which compound is 4-[3-(2-methyl-pyridin-4-yl)-phenyi]-8-trifluoromethoxy-l,3-dihydro-benzo[b] [l,4]diazepin-2-one 17. Compounds according to claim 4, wherein R1 is pyrazinyl, which is unsubstituted or substituted by one or two substituents sdected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, -(CH2)n-C(0)-OR", -(CH2)n-C(0)-NR'R", .(CH2)n-S02-NR'R', .(CH2)n-C(NH2)=NR", hydroxy, lower alkoxy, lower alkylthio, C3-C6-cydoalkyl and lower aEcyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrolidin-l-yl, azetidin-1-yl, cyano or carbamoyloxy, and R' and R" are independently from each other sdected from hydrogen, lower alkyl or C3-C6-cydoalkyl. 18. A compound according to claim 17, which compound is selected from the group consisting of 8-chloro-7-methyl-4-(3-pyra2in-2-yl-phenyl)-l,3-dihydro-ben2o[b][l,4]diazepin-2-one, 7-methyl-4-(3-pyrazin-2-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo[b][l,4]dia2epin-2-one, and 7-(methyl-propyl-amino)-4-(3-pyra2in-2-yl-phenyl)-8-trifluoromethyl-l,3-dihydro-benzo[b] [l,4]dia2epin-2-one. 19. Compounds according to claim 4, wherein R3 is pyrimidinyl or pyridazinyl, which are unsubstituted or substituted by one or two substituents selected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxyl, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, (CH2)n-C(0)-OR", -(CH2)n-C(0).NR'R", -(CH2)n-SO2-NR'R", -(CH2)n-C(NH2)=NR', hydroxy, lower alkoxyl, lower alkylthio, C3-C6-qrdoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrohdin-l-yl, azetidin-1-yl, cyano or carbamoyloxyl, and R' and R" are independently from each other selected from hydrogen, lower alkyl or C3-C6-cydoalkyl. 20. A compound according to daim 19, which compound is sdected from the group consisting of 8-cWoro-7-methyl-4-(3-pyrida2in-4-yl"phen)d)-13-dihydro-benzo[b][l,4]diaz^ one, 7-methyl-4-(3-pyridazm-4-yl-phenyi)-8-trifluoromethyl-13-dihydro-benzo[b] [ 1,4] diazepin-2-one, 8-(2-fluoro-phenyi)-4-(3-pyrimidra-5-yl-phenyi)-13-dihydro-benzo [b] [ 1,4] di one, and 4- [3-(6-methyl-pyrimidm-4-'5d)-phenyl] -8-trifluoromethyl-l,3-dihydro-benzo[b] [l,4]diazepin-2-one 21. Compounds according to daim 4, wherein R is pyridine-N-oxide, which is imsubstituted or substituted by one or two substituents sdected from the group consisting of halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, -(CH2)n-C(0)-OR", -(CH2)n-C(0)-NR'R", -(CH2VSO2-NR'R", -(CH2)n-C(NH2)=NR"', hydroxy, lower alkoxy, lower alkylthio, C3-C6-cydoalkyl and lower alkyl, which is optionally substituted by fluoro, -NR'R", hydroxy, lower alkoxy, pyrrolidin-l-yl, azetidin-1-yl, cyano or carbamoyoxy, and R' and R" are independmtly from each other sdected from hydrogen, lower alkyl or C3-C6-cydoaIkyl. 22. Compounds according to daim 3, wherein Y is -N=. 23. A compound according to daim 22, which compound is sdected from the group consisting of 4-[2,3']bipyridinyl-4-yl-7-methyl-8-trifluoromethyl-l,3-dihydro-ben2o[b][l,4]dia2epin-2-one, and 7-methyl-4-(2-methyl-[2,4']bipyridinyl-4-yl)-8-trifluoromethyl-l,3-dihydro-benzo[b] [l,4]dia2qpin-2-one. 24. A medicament containing one or more compounds of any one of daims 1 to 23 and pharmaceutically acceptable exdpients. 25, A medicament according to daim 24 for the treatment or prevention of acute and/or chronic neurological disorders inclliding psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits: 26. A process for preparing compounds of formula I as defined in daim 1, which process comprises converting the compound obtained into a pharmaceutically acceptable add addition salt 27. A compound according to any one of daims 1 to 23, whenever prepared by a process as daimed in daim 26 or by an equivalent method. 28. Compounds according to any one of daims 1 to 23 for the treatment or prevention of diseases. 29. The use of one or more compounds according to daims 1 to 23 and/or one or more of their pharmaceutically acceptable add addition salts for the manufacture of medicaments for the treatment or prevention of acute and/or chronic neurological disorders indliding psychosis, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits. 30. The invention as hereinbefore described. 31. A compound of general formula substantially as herein described and exemplified.

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