Title of Invention

SURGICAL CLIP FOR OCCLUDING A BODY PASSAGEWAY

Abstract

A surgical clip for occluding a body passageway, the clip comprising: a base portion, a pair of resilient limbs each extending from the base portion and each having a free end disposed forward of the base portion, and a reaction portion mounted to and extending from the base portion via a neck portion, the reaction portion defining a generally forwardly directed reaction surface disposed between the base portion and the free end of the limbs, the limbs being movable under a resilient restoring force from a first, open, condition, in which a gap is provided between the limbs and the reaction portion for receiving the body passageway into the clip, to a second, closed, condition, in which the limbs cooperate with the reaction portion to grip the body passageway to occlude the same, wherein the limbs each extend in generally opposite lateral directions from a point of connection to the base portion of the clip and each is configured along its length so that the free end of the limb is disposed forward of the base portion of the clip.

Full Text

FORM 2 THE PATENTS ACT, 1970 (39 of 1970) & THE PATENTS RULES, 2003 COMPLETE SPECIFICATION [See section 10, Rule 13] SURGICAL CLIP FOR OCCLUDING A BODY PASSAGEWAY; WILD, ANDREW, MICHAEL, A BRITISH NATIONAL OF BOX BCM 3715, LONDON WC1N 3XX, UNITED KINGDOM THE FOLLOWING SPECIFICATION PARTICULARLY DESCRIBES THE INVENTION AND THE MANNER IN WHICH IT IS TO BE PERFORMED. 1 Field of the invention The present invention relates to a surgical clip, particularly but not exclusively for use in haemostasis. Background of the Invention An example of a commercially available haemostatic locking clip is the Hem-o-lok ligating clip, available from Week Closure Systems, USA (web-site: www.weckclosure.com). This clip takes the form of a hinged plastic jaw with cooperating snap-fit closure formations on the end of each of the two jaw members. The clip is applied onto a blood vessel via a simple pliers-like applicator which closes the open jaw members together across the blood vessel, until the jaw members snap together. The clip has no inherent self closins bias, and the application mechanism is crude in that each clip must be loaded manually and individually on the applicator, in the open condition. To actuate the loaded applicator, a surgeon must make available his whole dominant hand, because of the pliers-grip hand action required. A permanent occlusion cerebral aneurysm clip is on the market from Aesculap, under the name of the Yasargil-Phynox aneurysm clip. This clip takes the form of a spring-hinged cobalt-chrome (or sometimes titanium) metal alloy jaw provided with a self closing spring bias. The clip is applied onto a cerebral blood vessel via a simple pliers-like applier which initially opens the jaw members against the spring bias, so that the open jaw can be applied across the blood vessel. The applier can then be released, so that the jaw members spring together. Again, this clip suffers from the disadvantages that each clip must be loaded manually and individually on the applier, in the open condition, and, to actuate the loaded 2. applier, a surgeon must make available his whole dominant hand, because of the pliers-grip hand action required. WO-A-00/35355, the disclosure of which is incorporated herein by reference, describes a surgical apparatus and method for occluding or encircling a body-passageway, e.g. for haemostasis. The method involves offering a surgical clip formed from a temperature-dependent shape-memory material, to a blood vessel or other body passageway in a first clip configuration at a temperature below body temperature, and allowing the temperature of the clip to rise by the proximity of the body passageway to the clip. The rise in temperature assists the clip to deform into a second, occluding, configuration in which the clip is closed around the body passageway. One particular clip design is shown in Figures 19 to 21 of this prior art. The clip comprises an elongate element formed of circular cross-section shape-memory metal (Nitinol) wire shaped to have generally first and second ends and a sinuously curved intermediate central portion. The first and second ends of the wire element form legs of the clip and the sinuously curved intermediate central portion forms two apices directed towards the legs, which provide shoulders to which the closing force of the legs in the second configuration is directed. In effect, the legs of the clip squeeze the body passageway against the apices of the central portion of the clip to provide occlusion of the body passageway. It is found that there is still room for improvement of the occlusive effect of the prior art clips. Brief Description of the Invention The present invention is based on my finding that the occlusive effect of the legs of such a clip on the body passageway is significantly improved if a reaction surface is provided as a feature of the clip. 3 Accordingly to the present invention, there is provided a surgical clip for occluding a body passageway, the clip comprising: a base portion, at least one resilient lirnb extending from the base portion and having a free end disposed forward of the base portion, and a reaction portion mounted to the base portion, the reaction portion defining a generally forwardly directed reaction surface disposed between the base portion and the free end of the limb or limbs, the limb or limbs being movable under a resilient restoring force from a first, open, condition, in which a gap is provided between the l:'mb or limbs and the reaction portion for receiving the body passageway into the clip, to a second, closed, condition, in which the limb or- limbs cooperate with the reaction portion to grip the body passageway to occlude the same. Detailed Description of the Invention Exemplified Features of the Clip Preferably, the limb or limbs of the clip extend generally laterally outwardly from the base portion of the clip. Most preferably, the clip has a pair of such limbs each extending in opposite lateral directions from the base portion of the clip. The base and reaction portions are preferably disposed generally centrally between the pair of limbs. The reaction surface is preferably substantially fixed in relation to the movement of the limb or limbs. The reaction surface is preferably elongate. The reaction surface may be straight or curved, and preferably has the form of a ridge or edge. The reaction surface and the limb or limbs are suitably dimensioned and arranged so that in the closed condition of the clip substantially the entire transverse widtli of the occluded body passageway is in contact with the reaction surface. The clip is preferably generally planar, but the respective planes of the parts may be offset against one another. Thus, for example, the plane of the reaction portion may be at a small angle (e.g. up to about 15°) to the plane of the base portion, with 4 a slight twist provided at the region of connection between the two portions. The plane of the or each limb may be at a small angle (e.g. up to about 15°) to that of the base portion. Where the clip has a pair of limbs, it is preferred that one limb lies slightly to one side of the plane of the base portion, and the other limb lies slightly to the opposite side of that plane. The free ends of the limbs thereby overlie each side of the reaction portion - itself preferably lying in a plane which is slightly offset relative to the plane of the base portion - in the closed condition of the clip. The direction and angular extent of the offsetting of the plane of the reaction portion are preferably such that the free end of a limb approaches close to the reaction surface in the closed c indition of the clip, enhancing the grip on an intervening body passageway in comparison with a clip hi which the reaction portion would not have been offset from the plane of the base portion. In this way. a particularly efficient and secure occlusive effect can be achieved, with less bending of the iimb(s) out of the.plane than would have been necessary to achieve the same occluding effect if the plane of the reaction portion were not offset in relation to the base portion. The reaction surface may be shaped in a manner generally complementary to the shape of those parts of the limb or limbs which cooperate with the reaction surface in the second condition of the clip. At least one of the opposed cooperating parts of tlie reaction surface and tlie limb or limbs may suitably be provided with surface projections which serve in use to enhance the grip on the body passageway. Guch projections may include rounded teeth, pointed teeth, nipping he-adr;, or any combination thereof. Teeth or nipping heads may be turned in tlie manner of a shark's fin, if desired. At least one of the reaction surface and the limb or limbs may suitably be provided with one or more guide projections which serve during closure of tlie clip to guide the body passageway to lie in a particular - preferably central - region of the clip. The guide projections may conveniently have a rounded shape. The reaction portion of the clip is preferably connected to the base portion via a relatively narrow neck. 5 It is preferred that the or each limb extends from the base portion of the clip behind the reaction portion of the clip and initially turns backwards, i.e. away from the forward facing direction of the reaction surface, and that the or each limb has at least one further turn ("elbow") in its length, after which it extends in the forwards direction to cause the free end of the limb to extend forwardly of the reaction surface. The turns may suitably be smooth curves. Such a configuration has the advantage that the stress applied to open the limbs against the resilient restoring (closing) force of the limbs is spread over a relatively long limb length, so reducing the risk of failure or loss of resilience. Furthermore, by providing for a relatively long limb length, useful leverage or mechanical advantage can be obtained in the closing of the limb towards the reaction surface. The majority of clip closure takes place at the elbow section of the limb. However, when the clip closes around a body passageway there is some straightening of the other turns, as additional length is transferred from such other sections into the gripping part of the limb, so providing the leverage referred to above. The base portion of the clip is suitably in the form of an open loop or generally U shaped member having a closed end directed away from the limb or limbs and an open end from which the limb or limbs and the reaction portion extend. As viewed from above the general piane of the clip, the clip has a left hand side and a right hand side. These sides may preferably be generally symmetrical about a central axis of symmetry. The open ends of the loop preferably lie close to either side of said axis in both the open and the closed conditions of the clip. The reaction portion of the clip may be connected to the base portion via a single neck region at one of said left and right sides of the loop of the base portion, or alternatively the reaction portion of the clip may be provided in two halves, each of which is connected to one side of the base portion via a neck region. The two halves may be complementarily juxtaposed to provide the reaction surface of the clip. The base portion of the clip is preferably provided with a weak region or point at which it may be cut after use in such a way that the clip, in its second, closed, condition, can be removed from the body passageway. The weak region or point may preferably be provided with a notch or mark to assist the procedure. 6 The pans of the clip are preferably integral with each other and the clip is preferably formed in one piece from a sheet of a resilient material. The sheet wall preferably have a uniform thickness in the range of about 500 to about 1000am, depending on the size of clip required. Suitable resilient materials include shape-memory materials whether of the temperature-induced or stress-induced type. Suitable materials are identified in WO-A-00/35355. A useful class of materials is that described generally as superelastic or stress-induced shape-memory materials. Such materials are well known in the art generally. A preferred material is Nitinol metal (nickel-titanium alloy), more preferably Nitinol having an Active Austenite Finish (Active Af) temperature of around 15°C within normal Nitinol tolerance. Manufacture of the Clip The clip may suitably be manufactured by photochemical etching or laser cutting from a sheet of the resilient material. A suitable sheet material will be a flat annealed, surface pickled. Nitinol sheet of 800um thickness, available from SMA, Inc. of San Jose, USA (web-site: www.sma-inc.com) under Alloy Code S (approx. 55.8 wt% nickel; balance titanium). Such a sheet has an Active Af temperature of around 15°C within normal Nitinol tolerance. Laser cutting is preferred. The use of an industrial laser has been found to be advantageous, in that no extraneous metals are added to the surface composition of the clip by this process. The laser cutting technique provides the required degree of accuracy and does not adversely affect the superelasticity of the Nitinol. The clip is preferably obtained initially as a planar blank with the limb(s) arranged in an intermediate condition, i.e. with the limb(s) neither fully opened, nor too closed to interfere with reaction portion. The intermediate condition should be sufficiently close to the first (open) condition that the first condition of the clip can be obtained by stressing the limb(s) outwardly by less than the maximum recoverable strain of the resilient material used. In the case of Nitinol, its maximum recoverable strain is 6 to 8%, which means in practice that the limb(s) of the blank as cut should lie sufficiently close to its/their orientation in the first 7 condition of the clip that the first condition can be achieved by moving the limb(s) outwardly by an angular deformation of less than about 8°. Following this, a batch of formed clips will preferably be sandblasted to remove burrs from the cut edges. After this, they undergo a two stage shape setting process (shape set annealing twice). In stage one, the reaction portion of the clip is rotated slightly out of the plane of the blank, sufficient to allow the limb(s) to move easily into the closed condition. The clip is then shape set annealed to permanently set this alteration. In stage two, the or each limb is turned inwards into the closed condition, e.g. using a jig. In addition, the or each limb is slightly off-set above or below the plane of the blank, to pass in front of, or behind, the reaction portion. The formed clip is then constrained and heat treated to permanently set the closed shape (shape set annealed). Lastly, the clips are suitably electropolished to round off the edges and the surface passivated by means of a biocompatible oxide or organic coating. Such a coating may suitably comprise titanium dioxide, parylene, or any other conventional biocompatable material. Before opening the clip, cooling needs to be applied to below tire Active Af temperature of the Nitinol. This technique is used to recover the intermediate condition prior to loading a plurality of clips into the applicator (see below). The clip will then show good superelasticity in response to a stress in a temperature window above the Active Af temperature and below body temperature. Under these conditions, the clip will move strongly to its second, closed condition. Use of the Clip The clip is primarily used to occlude a body passageway during surgery. The term "occlude" refers to an encircling and constricting action, rather than a piercing or cutting action. In some cases, the occlusive effect of the clip should be reversible. 8 The preferred embodiment of the clip of the present invention may be used either for reversible or for irreversible procedures, giving the patient a choice in appropriate cases between reversal and permanence. The clip is preferably applied to the body passageway to be occluded using an applicator apparatus corresponding generally to the apparatus described in \VO-A_-00/353855. A plurality of clips is held in a train in the apparatus with the limb(s) in an unstressed, intermediate, condition. In this unstressed condition, a substantial superelastic response tending to close the clip will not take place. In response to actuation of the applicator mechanism by the surgeon, one clip is stressed in the apparatus by being moved over a suitably shaped surface so that the limb(s) is/are deflected outwardly by an amount within the maximum recoverable stress of the material of the clip. The clip is then dispensed, limb(s) first, from a port of the apparatus, whereupon the limb(s) immediately close(s) around the body passageway and occlude(s) the same, preferably without cutting, puncturing or penetrating the body passageway or any adjacent structures. The port of the apparatus will be such that the clip is not fully released until the clip is well located. Depending on the material from which the clip is manufactured, it may not be necessary for any change in temperature to take place in order to induce the closure of the limb(s) into the second condition of the clip. The stressing immediately prior to dispensing of the clip from the apparatus will in many cases be sufficient to induce the resilient transformation of the clip. Alternatively, large clips may be applied manually to a body passageway, suitably with the aid of a trocar or other simple stressing device to slightly splay the limbs to activate the superelastic closing force. Wliere not otherwise stated herein, the details of the clip of the present invention will correspond generally to the clips defined and described in WO-A-00/35355 where the context permits. By providing a clip which has a reaction surface as described, the efficacy of the occluding and clamping action of the clip on a body passageway is markedly improved, particularly in the case of small arteries and veins that may otherwise be 9 difficult to close effectively. Furthermore, the clip of the present invention can be readily manufactured in large numbers from a sheet of the resilient material. The clip will be dimensioned according to the desired use. Typical uses of the clip will include the surgical closure of veins and arteries for haemostasis; ligation; male and female sterilisation; vascular occlusion; cardiac vessel occlusion; the occlusion of body ducts prior to resection; intracranial vessel occlusion for neurosurgery; occlusion of aberrant vessels or aneurysms such as intracranial aneurysm clipping: and occlusion of arterio-venous malformations. In each case, the clip can be dimensioned tc be suitable for paediatric, adult or veterinary surgery. A clip size of about 6mm width will generally be suitable for occluding body passageways having a diameter in the range of about 3 to about 5mm. Corresponding size adjustments can readily be made to cater for different sizes of passageway. The clips of the present invention may conveniently be supplied in standard sizes, to cater for body passageways within a defined diameter range. It is envisaged that clips may suitably be supplied in sizes suitable for l-2mm passageways. 2-3mm passageways, 3-5mm passageways, and so on. Brief Description of the Drawings An embodiment of the present invention will now be described in further detail, purely by way of example and without limitation, with reference to the accompanying drawings. In the drawings: Figure 1 shows a surgical clip in the first condition applied to a body passageway, looking along the line of the body passageway; 10 Figure 2 shows the surgical clip of Figure 1 omitting the body passageway for clarity, and in dotted lines the resting or intermediate condition of the clip prior to stressing to achieve the first condition; Figure 3 shows the surgical clip and body passageway in the closed condition (occluded body passageway); Figure 4 shows in perspective the surgical clip and body passageway of Figure 3 from front right; and Figure 5 shows the surgical clip in a fully closed condition achievable without a body passageway. _ Detailed Description of the Drawings Referring to the drawings, there is shown a surgical clip 1 for occluding a body-passageway 2, e.g. for haemostasis. The clip 1 comprises a base portion 3 and a pair of resilient limbs 4a. 4b extending laterally outwardly from the base portion. The limbs 4a, 4b are resiliently movable from a first, open, condition (Figure 1; Figure 2, solid lines), in which the limbs are spaced apart to define a gap for receiving the body passageway 2, to a second, closed condition (Figures 3 to 5), in which the limbs 4a, 4b are closed around the body passageway to occlude it. The occlusion of the body passageway is a simple closing (pinching), without puncture or rapture, and can be reversed by removing the clip, as will be described in more detail below. The base portion 3 of the clip is in the form of an open U-shaped loop having a closed end 5 directed away from the limbs 4a, 4b and open end 6 at which the limbs 4a, 4b are connected. As shown particularly in Figures 1 and 2, the clip consists of symmetrical left and right parts, the clip having a central axis of symmetry or midline 7. The closed end 5 of the loop is provided with a notch 8 defining a point at which the central body 11 portion 3 of the clip can be cut. Such cutting will release the clip from its closed condition on the body passageway (Figures 3 to 5), to enable removal of the clip from the body passageway. The clip 1 includes, in separate but complementarity juxtaposed left and right parts 9a, 9b with, respect to the central axis of symmetry 7 of the clip, a reaction portion which projects from the base portion and defines, at a location forward of the base portion but behind the free ends of the limbs 4a. 4b an elongate forwardly directed reaction surface 10 arranged cooperate with the limbs 4a, 4b in the second (closed) condition of the chp so that substantially the entire transverse width of the occluded body passageway 2 is in contact with the reaction surface 10 for being gripped between the limbs 4a, 4b and the reaction surface. The reaction surface 10 is in the general form of an edge which serves to pinch the body passageway 2 without severing it. Each of the left and right parts 9a,9b of the reaction portion is connected to the respective left or right side of the central body portion 3 of the clip via relatively thin neck 1 la. 1 lb. The reaction surface 10 and the limbs 4a, 4b are provided with rounded guide projections 12 which serve in use to guide the body passageway 2 to lie in a generally central region of clip. 1. As shown particularly in Figure 4, one limb 4a lies to one side of the edge of the reaction surface 10, i.e. slightly to the left of the vertical plane of the central body portion 3 of the clip as viewed, and the other limb 4b lies to the other side of the edge of the reaction surface 10, i.e. slightly to the right of the plane of the central body portion 3 of the clip as viewed. In addition, the central reaction portion 9a, 9b is rotated (off-set) anticlockwise from the neutral, planar, laser cut condition, to further facilitate movement of each of the limbs 4a, 4b to pass unhindered to its respective side of the reaction surface 10. The closure of the limbs 4a,4b is achieved by a straightening of some curves of the limbs and a tightening of others. The other portions of the clip are configured so that they do not foul the movement of the limbs. As previously explained, the shape of the limbs has been found to provide a useful leverage effect, maximising 12 the occlusive effect within the capabilities of the shape-memory material being used. The location of the reaction surface between the limbs and forward of the central body portion of the clip provides further advantages in that the occlusive effect can be achieved to the desired extent without excessive tightening of any curve of the limbs being required. The clip 1 is formed by laser cutting a suitable "blank" shape from a sheet of Nitinol alloy having an Active Af temperature of about 15°C. The thickness of the sheet will be chosen according to the desired dimensions, end use and closing force of the clip. I have found, for example, that a sheet thickness of between about 500 and 1000 urn (e.g. about 800 um) is suitable for forming a clip for occluding veins and arteries. The initially cut blank shape is planar and has the shape shown by the dotted lines in Figure 2. The closed condition of the limbs as shown in Figure 5 is then memorised into the clip in the manner described above. The initial orientation of the limbs is selected so that they are capable of being deflected slightly outwards (e.g. by an angle up to about 8°), within the limit of deformation, to stress the limbs and induce a superelastic or pseudoelastic response, urging the limbs to close when the stress is released. If the clip is not applied to a body passageway, the fully closed condition shown in Figure 5 will result, in which the limbs 4a and 4b lie across the off-set central reactive portion 9a and 9b. If, on the other hand, the clip is applied to a body passageway as described above, it will close to the condition shown in Figures 3 and 4 when the stress is released. After memorising of the shape, the clips are electropolished to round off the edges and a passive, closed layer of titanium dioxide is created (surface passivation), which is more biocompatible than the metal. The electropolisliing process reduces the clip thickness to about 730-750um. The active Af of the finished product is around 15°C, which means that the clips are superelastic, but also exhibit shape memory function (Austenite closed shape preference) at temperatures above 15°C. Chemical analysis confirms that the final composition of the clip contains 50.91 at% nickel and that the nickel content at the surface, following surface passivation, is 13 WE CLAIMS 1. A surgical clip for occluding a body passageway, the clip comprising: a base portion, a pair of resilient limbs each extending from the base portion and each having a free end disposed forward of the base portion, and a reaction portion mounted to and extending from the base portion via a neck portion, the reaction portion defining a generally forwardly directed reaction surface disposed between the base portion and the free end of the limbs, the limbs being movable under a resilient restoring force from a first, open, condition, in which a gap is provided between the limbs and the reaction portion for receiving the body passageway into the clip, to a second, closed, condition, in which the limbs cooperate with the reaction portion to grip the body passageway to occlude the same, wherein the limbs each extend in generally opposite lateral directions from a point of connection to the base portion of the clip and each is configured along its length so that the free end of the limb is disposed forward of the base portion of the clip. 2. A surgical clip according to claim 1, wherein the base and reaction portions are disposed generally centrally between the pair of limbs. 3. A surgical clip according to any one of the preceding claims, wherein the reaction surface is substantially fixed in relation to the remainder of the clip during movement of the limbs. 4. A surgical clip according to any one of the preceding claims, wherein the reaction surface is elongate. 5. A surgical clip according to any one of the preceding claims, wherein the reaction surface and the limbs are suitably dimensioned and arranged so that in the closed condition of the clip in use substantially the entire transverse width of the occluded body passageway is in contact with the reaction surface. 14 6. A surgical clip according to any one of the preceding claims, wherein at least two parts of the clip are generally planar and the respective planes are offset at an angle against one another. 7. A surgical clip according to any one of the preceding claims, wherein at least the base portion and the reaction portion of the clip are generally planar and the plane of the base portion is at a small angle to the plane of the reaction portion. 8. A surgical clip according to any one of the preceding claims, wherein the base portion, the reaction portion and each limb are generally planar and the plane of each limb is at an angle to the plane or planes of the base portion and the reaction portion. 9. A surgical clip according to any one of the preceding claims, wherein one limb lies slightly to one side of the plane or planes of the base portion and the reaction portions, and the other limb lies slightly to the opposite side of those planes, whereby the free ends of the limbs overlie opposite sides of the reaction portion in the closed condition of the clip. 10. A surgical clip according to any one of the preceding claims, wherein the reaction surface is shaped in a manner generally complementary to the shape of those parts of each limb which cooperate with the reaction surface in the closed condition of the clip. 11. A surgical clip according to any one of the preceding claims, wherein at least one of the opposed cooperating parts of the reaction surface and each limb is provided with surface projections which serve in use to enhance grip of the clip on the body passageway. 12. A surgical clip according to claim 11, wherein the surface projections are rounded teeth, pointed teeth, nipping heads, or any combination thereof. 13. A surgical clip according to any one of the preceding claims, wherein each limb is connected to the base portion of the clip via a curved portion of the limb defining a connection point to the base portion behind the reaction portion of the clip. 15 14. A surgical clip according to claim 13, wherein a further curve is provided in the limb in the opposite direction to the said curved portion, whereby the free end of the limb is disposed forward of the base portion of the clip. 15. A surgical clip according to claim 13 or claim 14, wherein an elongate portion is provided in each limb between the curves, whereby during closure a leverage effect is produced in use on the part of the limb which is in contact with the body passageway. 16. A surgical clip according to any one of the preceding claims, wherein the base portion of the clip is in the form of an open loop or generally U shaped member having a closed end directed away from the limbs and an open end at which the limbs and the reaction portion are connected to the base portion. 17. A surgical clip according to claim 16, wherein the reaction portion of the clip is provided in two halves, each of which is connected to one side of the open end of the base portion via a neck region. 18. A surgical clip according to any one of the preceding claims, wherein the base portion of the clip is provided with a weak region or point at which the base portion in use may be cut to remove the clip from the body passageway. 19. A surgical clip according to any one of the preceding claims, wherein the clip is integrally formed of a superelastic or pseudoelastic shape-memory materia!. 20. A surgical clip according to claim 19, wherein the clip is integrally formed of sheet nickel-titanium alloy. Dated this 14th day of September 2005 FOR WILD, ANDREW. MICHAEL BY His AGENT MANISH SAURASTRI (KRISHNA & SAURASTRI)

Documents:

1010-mum-2005-granted.pdf

1010-mumnp-2005-cancelled page(5-3-2007).pdf

1010-mumnp-2005-claim(granted)-(5-3-2007).doc

1010-mumnp-2005-claim(granted)-(5-3-2007).pdf

1010-mumnp-2005-correspondence(5-3-2007).pdf

1010-mumnp-2005-correspondence(ipo)-(20-12-2006).pdf

1010-mumnp-2005-drawing(5-3-2007).pdf

1010-mumnp-2005-form 1(14-9-2005).pdf

1010-mumnp-2005-form 1(5-3-2007).pdf

1010-MUMNP-2005-FORM 16(22-6-2011).pdf

1010-mumnp-2005-form 18(7-3-2006).pdf

1010-mumnp-2005-form 2(granted)-(5-3-2007).doc

1010-mumnp-2005-form 2(granted)-(5-3-2007).pdf

1010-mumnp-2005-form 3(14-9-2005).pdf

1010-mumnp-2005-form 3(5-3-2007).pdf

1010-mumnp-2005-form 5(14-9-2005).pdf

1010-mumnp-2005-form-pct-isa-210(14-9-2005).pdf

1010-mumnp-2005-power of attorney(14-9-2005).pdf

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