Title of Invention

MICROFLUIDIC SEPARATION DEVICES WITH ON-COLUMN SAMPLE INJECTION

Abstract A pressure-driven microfluidic device (100, 120, 200, 300, 400, 550, 601) for separating chemical or biological species from a sample includes on-column injection, namely, a separation channel (114, 142, 281, 310, 320, 330, 340, 350, 360, 370, 380, 420, 440, 460, 480, 561) containing stationary phase material (115, 138, 291, 319, 329, 339, 349, 359, 369, 379, 389, 429, 449, 469, 489, 571) and a sample input (110, 135A, 236A-236H, 314, 324, 334, 344, 354, 360A, 374, 384, 427A, 427B, 447, 467A, 467B, 487) disposed between a first end (114A, 142A, 281A, 310A, 320A, 330A, 340A, 350A, 360A, 370A, 380A, 420A, 440A, 460A, 480A, 561A) and a second end (114B, 142B, 281B, 310B, 320B, 330B, 340B, 350B, 360B, 370B, 380B, 420B, 440B, 460B, 480B, 561B) of the separation channel or column. One or many separation channels may be provided in a single microfluidic device, which may be fabricated with sandwiched stencil layers (102, 103, 122, 125, 202-208, 302, 305, 402, 405, 408) using various materials including polymers. Sealing means associated with a sample input, such as a mechanical seal (520, 530, 606) adapted to selectively seal the sample input, are provide. Various sample injector configurations are provided. A separation system including a microfluidic device having on-column injection further includes a pressure source (603) and a detector (607).
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Documents:


Patent Number 203230
Indian Patent Application Number 01335/KOLNP/2003
PG Journal Number 10/2007
Publication Date 09-Mar-2007
Grant Date 09-Mar-2007
Date of Filing 16-Oct-2003
Name of Patentee NANOSTREAM INC
Applicant Address 580 SIERRA MADRE VILLE,PASADENA,CA 91107,
Inventors:
# Inventor's Name Inventor's Address
1 HOBBS STEVEN E 22835 SHERMAN WAY, WEST HILLS,CA 91307,
2 KARP CHRISTOPH D 335 SOUTH GRAND OAKS AVENUE, PASADENA,CA 91107,
PCT International Classification Number G 01 N 30/60
PCT International Application Number PCT/US02/17958
PCT International Filing date 2002-06-06
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 10/161,415 2002-06-03 U.S.A.
2 60/296,897 2001-06-07 U.S.A.
3 60/357,683 2002-02-13 U.S.A.