Title of Invention | A NOVEL PROCESS FOR THE MANUFACTURE AND PURIFICATION OF COMPACTIN |
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Abstract | An improved method for the manufacture and purification of Compactin comprising - loading a contained bioreactor with solid state nutritive matrix and sterilizing it, - mixing the said sterilized solid state nutritive matrix with Penicillium citrinum, - incubating the said inoculated solid state nutritive matrix for 4 -6 days at 25 –30degereeC, - extracting the fermented matrix with an organic solvent or an aqueous buffer~ - concentrating the extract obtained, and re-extracting in ethyl acetate~ optionally giving the ethyl acetate extract a wash with saturated NaCI solution - concentrating the ethyl acetate extract and cooling the slurry obtained at 0 to 10 °C for 4 to 12 hours; - filtering to get crude crystals, optionally giving a hexane wash;. -dissolving the crude crystals in a water miscible solvent followed by the addition of filter aid and agitating for 0.5 to 3 hour;. - filtering get a clear solution which is concentrated and -crystallizing of the concentrate to get pure compactin. |
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in-pct-2002-1600-che abstract.pdf
in-pct-2002-1600-che claims granted.pdf
in-pct-2002-1600-che correspondence others.pdf
in-pct-2002-1600-che correspondence po.pdf
in-pct-2002-1600-che description (complete) granted.pdf
in-pct-2002-1600-che form 1.pdf
in-pct-2002-1600-che form 13.pdf
in-pct-2002-1600-che form 19.pdf
in-pct-2002-1600-che form 3.pdf
in-pct-2002-1600-che form 5.pdf
in-pct-2002-1600-che power of attorney.pdf
Patent Number | 202884 | |||||||||||||||||||||||||||
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Indian Patent Application Number | IN/PCT/2002/1600/CHE | |||||||||||||||||||||||||||
PG Journal Number | 05/2007 | |||||||||||||||||||||||||||
Publication Date | 02-Feb-2007 | |||||||||||||||||||||||||||
Grant Date | 30-Oct-2006 | |||||||||||||||||||||||||||
Date of Filing | 03-Oct-2002 | |||||||||||||||||||||||||||
Name of Patentee | M/S. BIOCON INDIA LIMITED | |||||||||||||||||||||||||||
Applicant Address | 20th Km Hosur Road, Hebbagodi, Bangalore 561 229 | |||||||||||||||||||||||||||
Inventors:
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PCT International Classification Number | C12P 17/06 | |||||||||||||||||||||||||||
PCT International Application Number | PCT/IN2000/000049 | |||||||||||||||||||||||||||
PCT International Filing date | 2000-04-27 | |||||||||||||||||||||||||||
PCT Conventions:
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