Title of Invention

METHOD AND APPARATUS FOR DETECTING ON-LINE HOMOGENEITY

Abstract

A method and apparatus for detecting on-line the homogeneity and constituent concentration of pharmaceutical compositions comprising mixing means for mixing the compositions of matter, and spectroscopic means for detecting on-line the homogeneity and constituent concentration of the compositions of matter, the spectroscopic means including a plurality of spectroscopic detection means disposed on the mixing means for providing light to the compositions of matter and detecting emission light from the compositions of matter, first control means for providing the light to the plurality of spectroscopic detection means and analyzing the emission light from the plurality of spectroscopic detection means, and second control means in communication with the first control means and the plurality of spectroscopic detection means for controlling the transmission of the light from the first control means to the plurality of spectroscopic detection means and the emission light from the plurality of spectroscopic detection means to the first control means the second control means including switch means for connecting a respective one of the plurality of spectroscopic detection means to the first control means.

Full Text

Method and Apparatus for Detecting On-Line Homogeneity FIELD OF THE PRESENT INVENTION The present invention relates generally to spectroscopy systems. More particularly, the invention relates to a method and apparatus for detecting on-line the homogeneity and constituent concentration of compositions of matter. BACKGROUND OF THE INVENTION A critical step in the preparation of a pharmaceutical compositions, which often comprises five (5) or more constituents, including the active drug(s), is mixing or blending. Indeed, it is imperative that the pharmaceutical composition is homogenous to ensure that the appropriate dosage of the active drug(s) is delivered to a recipient. The homogeneity and, of course, constituent concentration of pharmaceutical compositions are thus critical factors that are closely monitored during processing. Various conventional methods have been employed to determine the homogeneity and constituent concentration of pharmaceutical compositions. Most of the conventional methods are, however, complex and time consuming. The conventional methods typically involve stopping the blender and removing nine (9) or more samples from various locations in the blender. The samples are then taken to a laboratory and analyzed. The blender remains shut down while the samples are analyzed, which can take from 24 to 48 hours to complete. Another time consuming aspect of the traditional methods is the hit or miss approach to determine when the mixture is homogeneous. Typically, the blender is run for a pre-determined amount of time. The blender is then stopped and the samples are removed and analyzed. If the mixture is not homogenous, the blender is run again and the testing procedure is repeated. WO 02/18912 PCT/US01/26780 Further, the mixture may reach homogeneity at a time-point before the pre-determined set time for blending. In the first case more testing is carried out than is required, and in the second case valuable time is wasted in blending beyond the end-point. It is also possible that over blending can cause segregation of the constituents (or components). In U.S. Pat. No. 5,946,088 a further method of determining the homogeneity and drug concentration (i.e., potentency) of pharmaceutical compositions is disclosed. The method involves the use of a modified "V"-blender having spectroscopic detection means disposed proximate the axis of rotation. The "V"-blender is adapted to provide "on-line" spectroscopic characteristics as the "V"-blender is rotated. Although the method disclosed in. the '088 patent overcomes several of the above noted drawbacks associated with conventional methods of determining homogeneity and constituent concentration of pharmaceutical compositions, the method has several significant limitations. First, the method merely employs one (1) transflectance probe and is inherently limited to a maximum of two (2) probes. Second, the method is limited to a "V"-blender or. the like. It is therefore an object of the present invention to provide a method and apparatus for detecting on-line homogeneity and constituent concentration of pharmaceutical compositions that is readily adaptable to virtually all conventional blenders. It is another object of the invention to provide a method and apparatus for detecting on-line homogeneity and constituent concentration of pharmaceutical compositions that employs a plurality of spectroscopic detection means at various positions on the blender. It is yet another object of the invention to provide method and apparatus for detecting on-line homogeneity and constituent concentration of pharmaceutical compositions that includes control means to eliminate over mixing of the pharmaceutical composition. 2 WO 02/18912 PCT/US01/26780 SUMMARY OF THE INVENTION In accordance with the above objects and those that will be mentioned and will become apparent below, the method and apparatus for detecting on-line the homogeneity and constituent concentration of compositions of matter in accordance with this invention comprises mixing means for mixing the compositions of matter; and spectroscopic means for detecting on-line the homogeneity and constituent concentration of the compositions of matter, the spectroscopic means including a plurality of spectroscopic detection means disposed on the mixing means for providing light to the compositions of matter and detecting emission light from the compositions of matter, first control means for providing the light to the plurality of spectroscopic detection means and analyzing the emission light from the plurality of spectroscopic detection means, and second control means in communication with the first control means and the plurality of spectroscopic detection means for controlling the transmission of the light from the first control means to the plurality of spectroscopic detection means and the emission light from the plurality of spectroscopic detection means to the first control means, the second control means including switch means for connecting a respective one of the plurality of spectroscopic detection means to the first control means. BRIEF DESCRIPTION OF THE ACCOMPANYING DRAWINGS Further features and advantages will become apparent from the following and more particular description of the preferred embodiments of the invention, as illustrated in the accompanying drawings, and in which like referenced characters generally refer to the same parts or elements throughout the views, and in which: FIGURE 1 is a perspective view of a prior art tote blending system; FIGURE 2 is a partial section perspective view of a prior art mixing tote; FIGURE 3 is a perspective schematic illustration of the prior art mixing tote shown in FIGURE 2; 3 WO 02/18912 PCT/US01/26780 FIGURES 4-6 are partial section perspective views of the mixing tote shown in FIGURE 2, illustrating the detection means according to the invention; FIGURE 7 is a perspective view of a first embodiment of the invention; FIGURE 8 is a perspective view of the second control means according to the invention; FIGURE 9 is a partial section perspective view of the drive axle assembly according to the invention; FIGURE 10 is a further perspective view of the first embodiment of the invention shown in FIGURE 7, illustrating the system enclosure according to the invention; FIGURE 11 is a partial section perspective view of the mixing tote shown in FIGURE 2, illustrating the remote detection means according to the invention; and FIGURE 12 is a perspective view of a second embodiment of the invention, incorporating the remote detection means shown in FIGURE 11. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT The present invention substantially reduces or eliminates the disadvantages and drawbacks associated with prior art methods of determining homogeneity and constituent concentration of compositions of matter. As discussed in detail below, the invention provides a novel means for "on-line" determination of homogeneity and constituent concentration of compositions of matter and, in particular, pharmaceutical compositions at a plurality of positions in a mixing container or tote. The noted data may further be provided in a random manner or over a pre-determined time sequence. Different types of blenders or blending systems are currently used in the art for blending or mixing pharmaceutical compositions, such as a V-blender, core blender and ribbon blender. Illustrative is the blenders disclosed in U.S. pat. Nos 5,946,088 and 590,441 which are incorporated by reference herein. 4 WO 02/18912 PCT/US01/26780 A further blending system is the "tote blending" system distributed by Matcon USA, Inc., Sewall, New Jersey, which is incorporated by reference herein. As discussed in detail below, the blending system 5 mixes compositions of matter, such as powders or liquids, by rotating a "blending tote" 10 containing the composition of matter about an axis of rotation. The tote 10, illustrated in Figs. 2 and 3, typically has a height (H) in the range of 55" in. to 65" in. and is adapted to hold approximately 1586 liters of matter. Referring to Fig. 2, the blending tote 10 includes a substantially rectangular section 12 and a substantially tapered section 14 disposed on the bottom end thereof. The tote 10 also includes a first opening 1 la at the top of the tote 10 that is generally employed to charge the tote 10 with the individual compositions of matter that are to be mixed (or blended) and a second opening 1 lb at the bottom of the tote 10 that is generally employed to discharge the mixed, homogeneous composition. Openings 11 a, l1b are covered and sealed during the mixing process by conventional butterfly 13 or cone valves. The tote 10 further includes a plurality of corner posts 16 adapted to removeably engage the mixer clamping frame 18. As illustrated in Fig. 2, a respective post 16 is disposed at each top corner of the tote rectangular section 12. Referring to Figs. 1 and 3, the tote 10 is positioned in the mixer cage 22 such that the line that intersects points (or corners) A and B, designated L1 or the line that intersects points C and D, designated L2 is substantially coincident the rotational axis, RA, of the tote 10. As will be appreciated by one having ordinary skill in the art, the noted position of the tote 10 during rotation provides optimal blending of the matter contained therein. Thus, the tote blending system illustrated in Fig. 1 is the preferred blending means of the invention. However, as will also be appreciated by one having ordinary skill in the art, the method and apparatus of the invention, discussed in detail below, is also readily adaptable to the conventional blenders identified above. Referring back to Fig. 1, the tote 10 is secured in the cage 22 of the mixer 20 via the engagement of the linearly moveable clamping frame 18 and the tote corner posts 16. As illustrated in Fig. 1, the cage 22 is rotatably connected to the mixer support housing 23 via a conventional axle assembly 25 and the control housing 24 via a conventional "drive" axle 5 WO 02/18912 PCT/US01/26780 assembly 26. The cage 22 and, hence, tote 10 is rotated about axis RA via conventional drive means 21 that is operatively connected to the drive axle assembly 26 (See Pig. 7). As will be appreciated by one having ordinary skill in the art, various conventional "rotation means", such as the noted axle assemblies 25, 26, may be employed within the scope of the invention to facilitate rotatable connection of the cage 22 to the housings 23,24. The conventional rotation means may also be employed with the additional mixing means identified above. As further illustrated in Fig. 1, the blending system 5 typically comprises an open, stand-alone system. However, as illustrated in Fig. 10, the blending system 5 may include an enclosure 6 to meet stringent safety and quality control requirements. As indicated above, a key feature of the present invention is the spectroscopic means. In a preferred embodiment of the invention, the spectroscopic means includes a plurality of spectroscopic detection means to determine the homogeneity and constituent concentration of. the pharmaceutical composition during the mixing operation (i.e., on-line). By the term "spectroscopic detection means", as used herein, it is meant to mean and include a reflectance probe, transflectance probe, near-infrared spectrophotometer, ultraviolet spectrophotometer, mid-range infrared spectrophotometer, visible spectrophotometer, fluorescence spectrophotometer and Raman spectrophotometer. Referring now to Fig. 7, according to the invention, the spectroscopic means 30 of the invention further includes (i) first control means 34 having light source means 34a for providing the desired wavelength of light (or radiation) to the spectroscopic detection means 32 and analyzer means 34b for analyzing the emission light detected by the spectroscopic detection means 32, and (ii) second control means 36 having a plurality of optic lead inputs 38 and switch means adapted to selectively facilitate communication by and between the primary optic lead 40 and a selective one of the optic lead inputs 38 (See Figs. 8 and 9). Carl Zeiss, which are incorporated by reference herein. The analyzer means 34b may also comprise a personal computer. 6 WO 02/18912 PCT/US01/26780 As illustrated in Figs. 7-9, the spectroscopic means 30 further includes (i) at least one detection means lead 42, having conduction means for conducting light, (ii) a first control lead 46 that is operatively connected to the control panel 48 and the first control means 34, and (iii) a second control lead 44 that is operatively connected to the first and second control means 34, 36 to facilitate transmission of at least a first control signal from the second control means 36 to the first control means 34 indicative of the location of a respective one of the spectroscopic detection means 32 that is in communication with the first control means 34 (via the second control means switch means), a second control signal from the first control means 34 to the second control means 36 to control the conduction of the light from the light source means 34a to a respective one of the spectroscopic detection means 32, and a third control signal for controlling the conduction of emission light from a respective one of the spectroscopic detection means 32 to the analyzer means 34b. According to the invention, the first control means 34 is preferably disposed in the control housing 24. The second control means 36 is preferably mounted to the mixer cage 22 (See Fig. 7). Referring now to Fig. 9, to facilitate communication by and between the first and second control means 34, 36, the drive axle assembly 26 (i.e., rotation means) includes a first (or outer) member 50 adapted to rotate with the cage 22 and, hence, mixing tote 10 and a second (or inner) member 52 adapted to remain relatively fixed in relation to the first member 50 during rotation of the cage 22. In a preferred embodiment of the invention, the second member 52 comprises a rotatable sleeve assembly. As illustrated in Fig. 9, the sleeve assembly 52 includes a substantially lateral communication port 54 adapted to receive the primary optic lead 40 and second control lead 44. Thus, during rotation of the first member 50, the sleeve assembly 52 remains relatively fixed to eliminate "kinking" of the leads 40, 44. As will be appreciated by one having ordinary skill in the art, various conventional rotation means having at least two rotatable members may be employed within the scope of the invention to facilitate rotation of one member in communication with the cage 22 (or other mixer/blender) relative to a second member that receives the leads 40,44 and remains 7 WO 02/18912 PCT/US01/26780 relatively fixed during rotation of the first member. Such rotation means includes a " conventional bearing assembly and bushing assembly. Referring now to Fig. 4, there is shown one embodiment of the invention wherein two (2) spectroscopic detection means 32 are employed. The spectroscopic detection means 32 are preferably disposed proximate the bottom of the mixing tote 10. However, as indicated, a plurality of spectroscopic detection means 32 disposed at various positions, such as that illustrated in Figs. 5 and 6, may be employed within the scope of the invention. In a preferred embodiment, at least ten (10) spectroscopic detection means 30 are employed (See, e.g., Fig. 6). As illustrated in Fig. 7, each of the spectroscopic detection means 32 shown in Fig. 4 is operatively connected to the second control means 36 via detection means leads 42. As indicated above, each lead 42 includes conduction means, such as a light pipe, optics and fiber optic bundle. In a preferred embodiment of the invention, the conduction means comprises a fiber optic bundle having two sets of optical fibers; a first set of optical fibers to convey light from the first control means 34 (i.e., light source means 34a) to the spectroscopic detection means 32 and, hence, mixture inside the mixing tote 10 and a second set of optical fibers to convey the detected (i.e., emission) light back to the first control means 34 (i.e., analyzer means 34b). As indicated above, various spectroscopic detection means 32 may be employed within the scope of the invention. In a preferred embodiment, the spectroscopic detection means 32 comprises a reflectance probe. A typical reflectance probe if disclosed in U.S. Pat. No. 5,044,755, which is incorporated by reference herein. In the noted reflectance probe, a lens collimates the light emerging from the fiber optic bundle. The optic ray is then guided through a sample cell and reflected back to the same lens that focuses the light into the same fiber optic bundle. According to the invention, the mixing and detection process of the invention comprises the following: The mixing tote 10 charged with the pharmaceutical composition is initially loaded into the mixer 20 and secured therein by the clamping frame 18. The 8 WO 02/18912 PCT/US01/26780 detection means leads 42 are then connected to each detection means 32 (i.e., reflectance probe) and a respective optic lead input 38 of the second control means 36. The location of each detection means lead 42 on the second control means 36 (i.e., optic lead input 38), the corresponding location of a respective one of the spectroscopic detection means 32, and the desired spectroscopic scanning sequence are entered into the system 5 via the control panel 48. Further information, such as mix time and/or sequence, and desired homogeneity and concentration levels, may also be inputted into the system 5 via the control panel 48. .The noted information is then communicated to the first control means 34 via first control lead 46. The mixing tote 10 is then rotated by the mixer 20 (See Fig. 10) and the desired spectroscopic data (e.g., absorption spectrum) is acquired by the spectroscopic means 30 pursuant to the inputted spectroscopic scanning sequence. As discussed above, the spectroscopic data is then communicated to the analyzer means 34b where the homogeneity and constituent concentration of the pharmaceutical composition is determined by conventional means. According to the invention, the tote 10 is rotated for either a pre-determined period of time or until the pharmaceutical composition contained in the tote 10 reaches a desired level of homogeneity. The desired homogeneity level may be either the average of the spectroscopic data detected by all detection means 32 or the minimum value detected by each detection means 32. As illustrated in Fig. 7, the control panel 48 further includes display means 49 adapted to visually display a variety of parameters, including the homogeneity and/or constituent concentration of the pharmaceutical composition proximate each spectroscopic detection means 32 during virtually any point in the mixing process. The display means 49 are further adapted to visually display other pertinent information, such as the heat or batch number, operator identification, etc.. Referring now to Fig. 11, there is shown an additional embodiment of the invention. In the noted embodiment, a plurality of spectroscopic detection means 32 are similarly 9 WO 02/18912 PCT/US01/26780 employed. However, as illustrated in Fig. 11, each spectroscopic detection means 32 includes intergral control means 60. According to the invention, the control means 60 similarly includes light source means for providing the desired wavelength of light to the detection means 32 and analyzer means for analyzing the emission light detected by the spectroscopic detection means 32. The control means 60 further includes means for remotely transmitting at least a first detection signal indicative of the spectroscopic characteristics of the pharmaceutical composition contained in the tote 10 and receiving at least a first control signal from the control panel 70. According to the invention, the means for transmitting and receiving the first detection signal and first control signal can comprise a radio frequency (RF) transmitter/receiver, an infrared transmitter/receiver and a low power microwave transmitter/receiver., In a preferred embodiment of the invention, the means for transmitting and receiving the noted signals comprises a RF transmitter/receiver 62. According to the invention, the control panel 70 also includes a RF transmitter/receiver 72. The RF transmitter/receiver 72 is adapted to receive the first detection signal from each respective control means 62 and transmit the first control signal to each of the control means 62. Referring now to Fig. 12, the control panel 70 is preferably mounted to the mixing housing 24. The control panel 70 also includes display means 74 that is capable of visually displaying the same information discussed above. Operation of the spectroscopic system illustrated in Figs. 11 and 12 is also quite similar to the operation of the above-discussed embodiment. However, in this instance, the spectroscopic characteristics are directly communicated to the display means 74 via RF signals. The second control means 36 and leads 40, 42, 44 discussed above are thus eliminated. 10 WO 02/18912 PCT/US01/26780 SUMMARY From the foregoing description, one of ordinary skill in the art can easily ascertain that the present invention provides novel means for accurate, cost efficient, on-line detection of homogeneity and concentration of pharmaceutical compositions that is readily adaptable to virtually all conventional blenders and blending systems. Without departing from the spirit and scope of this invention, one of ordinary skill can make various changes and modifications to the invention to adapt it to various usage and conditions. As such, these changes and modifications are properly, equitably, and intended to be, within the full range of equivalence of the following claims. 11 WE CLAIM: 1. An apparatus for mixing compositions of matter and detecting on-line the homogeneity and constituent concentration of said compositions of matter, comprising: mixing means for mixing said compositions of matter; and spectroscopic means for detecting on-line the homogeneity and constituent concentration of said compositions of matter, said spectroscopic means comprising plurality of spectroscopic detection means disposed on said mixing means for providing light to said compositions of matter and detecting emission light from said compositions of matter, first control means for providing said light to said plurality of spectroscopic detection means and analyzing said emission light from said plurality of spectroscopic detection means, said first control means comprising light source means for providing a predetermined wavelength of said light to said plurality of spectroscopic detection means and analyzer means for analyzing said emission light detected by said plurality of spectroscopic detection means, and second control means in communication with said first control means and said plurality of spectroscopic detection means for controlling the transmission of said light from said light source means to said plurality of spectroscopic detection means and said emission light from said plurality of spectroscopic detection means to said analyzer means, said second control means having switch means for connecting a respective one of said plurality of spectroscopic detection means to said first control means. 2. The apparatus as claimed in claim 1, wherein said mixing means comprises a mixing tote. 3. The apparatus as claimed in claim 1, wherein said mixing means comprises a blender selected from the group consisting of a V-blender, core blender and ribbon blender. 4. The apparatus as claimed in claim 1, wherein each of said plurality of spectroscopic detection means comprises a reflectance probe. 5. The apparatus as claimed in claim 1, wherein each of said plurality of spectroscopic detection means comprises a transflectance probe. 12 6. The apparatus as claimed in claim 1, wherein each of said plurality of spectroscopic detection means comprises a spectrophotometer selected from the group consisting of a near infrared spectrophotometer, an ultra-violet spectrophotometer, a mid-range infrared spectrophotometer, a visible spectrophotometer, a fluorescent spectrophotometer and a Raman spectrophotometer. 7. The apparatus as claimed in claim 1, wherein said spectroscopic means comprises first conduction means for conducting said light from said light source means to said second control means and conducting said emission light from said second control means to said analyzer means and at least one second conduction means for conducting light from said second control means to a respective one of said plurality of spectroscopic detection means and conducting said emission light from said respective one of said plurality of spectroscopic detection means to said second control means. 8. The apparatus as claimed in claim 1, wherein said plurality of spectroscopic detection means comprises at least ten spectroscopic detection means. 9. An apparatus for mixing compositions of matter and for detecting on- line the spectroscopic characteristics of said compositions of matter, comprising: mixing means for mixing said compositions of matter, said mixing means comprising a container, said mixing means being adapted to rotate about an axis of rotation, said mixing means comprising first and second rotation means disposed proximate said axis of rotation to facilitate rotation of said mixing means, said first rotation means being in communication with a first support and said second rotation member being in communication with a second support, at least one of said first and second rotation means comprising a first member adapted to rotate with said mixing means and a second member adapted to remain relatively fixed in relation to said first member during said rotation of said first member, said second member having a communication port therethrough; and spectroscopic means for detecting on-line the spectroscopic characteristics of said compositions of matter, said spectroscopic means comprising a plurality of spectroscopic detection means for providing light to said compositions of matter and detecting emission light from said compositions of matter, said plurality of spectroscopic detection means being disposed at a plurality of different locations on said container, 13 said spectroscopic means comprising first control means for providing said light to said plurality of spectroscopic detection means and analyzing said emission light from said plurality of spectroscopic detection means, said first control means comprising light source means for providing a predetermined wavelength of said light to said plurality of spectroscopic detection means and analyzer means for analyzing said emission light detected from said plurality of spectroscopic detection means, and second control means in communication with said first control means and said plurality of spectroscopic detection means, said second control means comprising switch means for connecting a respective one of said plurality of spectroscopic detection means to said first control means, said second control means: having first conduction means for conducting said light from said light source means to said second control means and conducting said emission light from said second control means to said analyzer means and a plurality of second conduction means for conducting said light from said second control means to said plurality of spectroscopic detection means and conducting said emission light from said plurality of spectroscopic detection means to said second control means, said first conduction means being removeably disposed in said communication port. 10. The apparatus as claimed in claim 9, wherein said mixing means comprises a mixing tote. 11. The apparatus as claimed in claim 9, wherein said mixing means comprises a blender selected from the group consisting of a V-blender, core blender and ribbon blender. 12. The apparatus as claimed in claim 9, wherein each of said plurality of spectroscopic detection means comprises a reflectance probe. 13. The apparatus as claimed in claim 9, wherein each of said plurality of spectroscopic detection means comprises a transflectance probe. 14. The apparatus as claimed in claim 9, wherein each of said plurality of spectroscopic detection means comprises a spectrophotometer selected from the group consisting of a near infrared spectrophotometer, an Ultra-violet spectrophotometer, a mid-range infrared spectrophotometer, a visible spectrophotometer, a fluorescent spectrophotometer and a Raman spectrophotometer. 15. The apparatus as claimed in claim 9, wherein each of said plurality of second conduction means has a first end adapted to be removeably connected to a respective one of 14 said plurality of spectroscopic detection means and a second end adapted to be removeably connected to said second control means. 16. The apparatus as claimed in claim 15, wherein said second control means comprises a plurality of second conduction means inputs, each of said plurality of second conduction means inputs being adapted to receive said second end of a respective one of said second conduction means. 17. The apparatus as claimed in claim 16, wherein said first control means ¦ comprises: (a) means for determining the location of each of said plurality of spectroscopic detection means on said container; (b) means for controlling the conduction of said light from said light source means to a respective one of said plurality of spectroscopic detection means; and (c) means for selecting a respective one of said plurality of spectroscopic detection means for conducting said emission light from said one of said plurality of spectroscopic detection means to said analyzer means. 18. The apparatus as claimed in claim 17, wherein said spectroscopic means comprises a control lead in communication with said first and second control means adapted to transmit at least a first signal from said second control means to said first control means indicative of the location of a respective one of said plurality of spectroscopic detection means that is in communication with said first control means during rotation of said container. 19. The apparatus as claimed in claim 18, wherein said control lead is removeably disposed in said communication port. 20. An apparatus for mixing compositions of matter 'and detecting on-line the spectroscopic characteristics of said compositions of matter, comprising: mixing means for mixing said compositions of matter; spectroscopic means for detecting on-line said spectroscopic characteristics of said compositions of matter, said spectroscopic means comprising a plurality of spectroscopic detection means disposed at a plurality of different positions on said mixing means for providing light to said compositions of matter and detecting emission light from said compositions of matter, each of said plurality of spectroscopic detection means comprising first control means for providing said light to said spectroscopic detection means and analyzing 15 said emission light from said spectroscopic detection means, said first control means comprising first communication means for remotely transmitting at least a first detection signal indicative of said spectroscopic characteristics of said compositions of matter and receiving at least a first control signal; and second control means for controlling said transmission of said first detection signal, said second control means comprising second communication means for transmitting said first control signal to said plurality of first control means and receiving said first detection signal. 21. The apparatus as claimed in claim 20, wherein said mixing means comprises a mixing tote. 22. The apparatus as claimed in claim 20, wherein said mixing means comprises; a blender selected from the group consisting of a V-blender, core blender and ribbon blender. 23. The apparatus as claimed in claim 20, wherein each of said plurality of spectroscopic detection means comprises a reflectance probe. 24. The apparatus as claimed in claim 20, wherein each of said plurality of spectroscopic detection means comprises a transflectance probe. |25. The apparatus as claimed in claim 20, wherein each of said plurality of spectroscopic detection means comprises a spectrophotometer selected from the group consisting of a near infrared spectrophotometer, an ultra-violet spectrophotometer, a mid-range infrared spectrophotometer, a visible spectrophotometer, a fluorescent spectrophotometer and a Raman spectrophotometer. 26. The apparatus as claimed in claim 20, wherein said plurality of spectroscopic detection means comprises at least ten spectroscopic detection means. 27. The apparatus as claimed in claim 20, wherein said first and second communication means comprises a radio frequency transmitter/receiver. 28. The apparatus as claimed in claim 20, wherein said first and second communication means comprises an infrared transmitter/receiver. 29. The apparatus as claimed in claim 20, wherein said first and second communication means comprises a micorwave transmitter/receiver. 30. A method for mixing compositions of matter and detecting on-line the spectroscopic characteristics of said compositions of matter, comprising the steps of: 16 WO 02/18912 PCT/US0l/26780 placing said compositions of matter into mixing means; mixing said compositions of matter; 17 detecting on-line the spectroscopic characteristics of said compositions of matter with spectroscopic means, said spectroscopic means including a plurality of spectroscopic detection means disposed on said mixing means for providing light to said compositions of matter and detecting emission light from said compositions of matter, first control means for providing said light to said plurality of spectroscopic detection means and analyzing said emission light from said plurality of spectroscopic detection means, and second control means in communication with said first control means and said plurality of spectroscopic detection means for controlling the transmission of said light from said first control means to said plurality of spectroscopic detection means and said emission light from said plurality of spectroscopic detection means to said first control means, said second control means including switch means for connecting a respective one of said plurality of spectroscopic detection means to said first control means. A method and apparatus for detecting on-line the homogeneity and constituent concentration of pharmaceutical compositions comprising mixing means for mixing the compositions of matter, and spectroscopic means for detecting on-line the homogeneity and constituent concentration of the compositions of matter, the spectroscopic means including a plurality of spectroscopic detection means disposed on the mixing means for providing light to the compositions of matter and detecting emission light from the compositions of matter, first control means for providing the light to the plurality of spectroscopic detection means and analyzing the emission light from the plurality of spectroscopic detection means, and second control means in communication with the first control means and the plurality of spectroscopic detection means for controlling the transmission of the light from the first control means to the plurality of spectroscopic detection means and the emission light from the plurality of spectroscopic detection means to the first control means the second control means including switch means for connecting a respective one of the plurality of spectroscopic detection means to the first control means.

Documents:

00223-kolnp-2003 abstract.pdf

00223-kolnp-2003 claims.pdf

00223-kolnp-2003 correspondence.pdf

00223-kolnp-2003 description(complete).pdf

00223-kolnp-2003 drawings.pdf

00223-kolnp-2003 from-1.pdf

00223-kolnp-2003 from-18.pdf

00223-kolnp-2003 from-2.pdf

00223-kolnp-2003 from-3.pdf

00223-kolnp-2003 from-5.pdf

00223-kolnp-2003 gpa.pdf

00223-kolnp-2003 priority document.pdf

223-kolnp-2003-granted-abstract.pdf

223-kolnp-2003-granted-claims.pdf

223-kolnp-2003-granted-correspondence.pdf

223-kolnp-2003-granted-description (complete).pdf

223-kolnp-2003-granted-drawings.pdf

223-kolnp-2003-granted-examination report.pdf

223-kolnp-2003-granted-form 18.pdf

223-kolnp-2003-granted-form 2.pdf

223-kolnp-2003-granted-form 3.pdf

223-kolnp-2003-granted-form 5.pdf

223-kolnp-2003-granted-gpa.pdf

223-kolnp-2003-granted-letter patent.pdf

223-kolnp-2003-granted-reply to examination report.pdf

223-kolnp-2003-granted-specification.pdf

223-kolnp-2003-granted-translated copy of priority document.pdf