Title of Invention

PROCESS FOR THE PREPARATION OF THIAZOLE INTERMEDIATE

Abstract The present invention provides a process for the preparation of 4-methyl-5- formyl-thiazole of the formula (I) which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using a sodium borohydride, in the presence of AlCI3, in a solvent, and oxidising the thiazole alcohol of the formula (IV) to 4-methyl-5- formyl-thiazole of the formula (I) using an oxidizing agent.
Full Text

Claims
1. A process for the preparation of 4-methyl-5-formyl-thiazole of the formula
(I)
which comprises oxidising the 4-methyl-5-hydroxymethyl thiazole of the formula (IV)to 4-methyl-5-formyl-thiazole of the formula (I), by using an oxidizing agent in the presence of a solvent.
2. A process for the preparation of 4-methyl-5-hydroxymethyl thiazole of the
formula (IV), which comprises reducing the thiazole ester of the formula (III)

where R represents (C1-C4)alkyl group such as methyl, ethyl, n-propyl, iso-propyl, tert-butyl to 4-methyl-5-hydroxymethyl thiazole of the formula (IV),

using sodium borohydride, in the presence of AICI3, in a solvent.
3. The process according to claim 1 wherein the oxidizing agent used in step (ii) is selected from pyridinum chlorochromate, NaOCl and KBr in presence of TEMPO or Jones reagent (CrO3).
4. The process according to claim 1 wherein the solvent used is selected from dichloromethane or ethylacetate.

5. The process according to claim 2 wherein the solvent used is selected from monoglyme, THF or diglyme.


Documents:

325-abs.jpg

325-mas-2002-abstract.pdf

325-mas-2002-claims .pdf

325-mas-2002-correspondence others.pdf

325-mas-2002-correspondence po.pdf

325-mas-2002-description complete.pdf

325-mas-2002-form 1.pdf

325-mas-2002-form 13.pdf

325-mas-2002-form 3.pdf

325-mas-2002-form 5.pdf

325-mas-2002-pct.pdf


Patent Number 194928
Indian Patent Application Number 325/MAS/2002
PG Journal Number 30/2009
Publication Date 24-Jul-2009
Grant Date 05-Jan-2006
Date of Filing 26-Apr-2002
Name of Patentee M/S. ORCHID CHEMICALS & PHARMACEUTICALS LTD.,
Applicant Address 1, 6TH FLOOR, CROWN COURT, 34, CATHEDRAL ROAD, TN, CHENNAI 600 086
Inventors:
# Inventor's Name Inventor's Address
1 PANDURANG BALWANT DESHPANDE T-1, NAVIN'S VASUNDHARA 12TH CROSS ROAD, DOOR NO.5, INDIRA NAGAR, CHENNAI 600 020
2 RAMAKRISHNA KAMMA 101,3RD CROSS STREET, THIRUMALAI NAGAR,PERUNGUDI, CHENNAI 600 096.
3 PARVEN KUMAR LUTHRA H-85,S-1,TNHB FLATS, VALMIKI NAGAR,THIRUVANMIYUR, CHENNAI 600 041.
4 RAJESH VYAS 97,L.B.ROAD, ADYAR, CHENNAI 600 041.
PCT International Classification Number A61K31/425
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA