Title of Invention | PROCESS FOR THE PREPARATION OF THIAZOLE INTERMEDIATE |
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Abstract | The present invention provides a process for the preparation of 4-methyl-5- formyl-thiazole of the formula (I) which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using a sodium borohydride, in the presence of AlCI3, in a solvent, and oxidising the thiazole alcohol of the formula (IV) to 4-methyl-5- formyl-thiazole of the formula (I) using an oxidizing agent. |
Full Text | Claims 1. A process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) which comprises oxidising the 4-methyl-5-hydroxymethyl thiazole of the formula (IV)to 4-methyl-5-formyl-thiazole of the formula (I), by using an oxidizing agent in the presence of a solvent. 2. A process for the preparation of 4-methyl-5-hydroxymethyl thiazole of the formula (IV), which comprises reducing the thiazole ester of the formula (III) where R represents (C1-C4)alkyl group such as methyl, ethyl, n-propyl, iso-propyl, tert-butyl to 4-methyl-5-hydroxymethyl thiazole of the formula (IV), using sodium borohydride, in the presence of AICI3, in a solvent. 3. The process according to claim 1 wherein the oxidizing agent used in step (ii) is selected from pyridinum chlorochromate, NaOCl and KBr in presence of TEMPO or Jones reagent (CrO3). 4. The process according to claim 1 wherein the solvent used is selected from dichloromethane or ethylacetate. 5. The process according to claim 2 wherein the solvent used is selected from monoglyme, THF or diglyme. |
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325-mas-2002-correspondence others.pdf
325-mas-2002-correspondence po.pdf
325-mas-2002-description complete.pdf
Patent Number | 194928 | |||||||||||||||
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Indian Patent Application Number | 325/MAS/2002 | |||||||||||||||
PG Journal Number | 30/2009 | |||||||||||||||
Publication Date | 24-Jul-2009 | |||||||||||||||
Grant Date | 05-Jan-2006 | |||||||||||||||
Date of Filing | 26-Apr-2002 | |||||||||||||||
Name of Patentee | M/S. ORCHID CHEMICALS & PHARMACEUTICALS LTD., | |||||||||||||||
Applicant Address | 1, 6TH FLOOR, CROWN COURT, 34, CATHEDRAL ROAD, TN, CHENNAI 600 086 | |||||||||||||||
Inventors:
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PCT International Classification Number | A61K31/425 | |||||||||||||||
PCT International Application Number | N/A | |||||||||||||||
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PCT Conventions:
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