Title of Invention

A PROCESS FOR THE PREPARATION OF HYDROCHLORIC ACID SALT

Abstract

The present invention relates to a process for the preparation of an hydrochloric acid salt of an optically active phenylglycine derivative in which in an asymmetric transformation a diastereoisomeric salt is formed of the optically active phenylglycine derivative and an optically active acid.The resulting mixture is subsequently treated with an equivalent amount of hydrochloric acid relative to the amount of diastereoisomeric salt without intermediate isolation of the diastereoisomeric salt and in which the mother liquor containing the optically active acid and remaining after recovery of the hydrochloric acid salt of the phenylglycine derivative, is reused in the asymmetric transformation process.

Full Text

The invention relates to a process for the preparation of an inorganic salt of an optically active phenylglycine derivative in which a diastereoisomeric salt of the optically active phenylglycine derivative and an optically active acid is treated with a strong inorganic acid. Such a process is described in EP-A-442584, in which the L-mandelic acid salt of D-phenylglycineamide after an asymmetric transformation reaction, is filtered off from the reaction mixture, washed and subsequently dissolved in water and converted into the D-PGA.HC1 salt with the aid of HC1. The known process for converting the mandelic acid salt of D-PGA into the D-PGA.HC1 salt is very complex and involves substantial losses of D-PGA and L-mandelic acid. The aim of the invention is to provide a process that does not present the above drawbacks. This is achieved according to the invention by adding at least a portion of the strong inorganic acid to a reaction mixture containing an amount of the diastereoisomeric salt as a solid substance. Surprisingly, it has been found that it is possible to realize full conversion of the diastereoisomeric salt of the phenylglycine derivative and the optically active acid into the inorganic salt of the optically active phenylglycine derivative without isolation and/or dissolution of the fliastereoisomeric salt and with the optical activity, to be expressed in enantiomeric excess (e.e.) being retained. Asymmetric transformations in which one enantiomer is isolated from a racemic mixture and the other enantiomer is racemized in situ are known in the literature and are described in for example the aforementioned patent application EP-A-442584. For a commercially attractive process an efficient recovery of both the optically active phenylglycine derivative and the optically active acid is however of great importance. The known methods for the recovery of the optically active enantiomer and the optically active acid are complex, however. For example, in EP-A-442584 the optically active phenylglycine derivative is obtained from the isolated diastereoisomeric salt by dissolving the salt in a mixture of water and an almost equimolar amount of mineral acid such as hydrochloric acid, sulphuric acid, nitric acid or phosphoric acid and extracting the optically active carboxylic acid with the aid of an extractive-distillation agent. This process is rather laborious; it moreover often involves the loss of a significant portion of the optically active acid. The process according to the invention can with particular advantage be applied to the reaction mixture obtained after the asymmetric transformation. The invention hence also relates to a process for the preparation of an optically active phenylglycine derivative in which the reaction mixture obtained after the asymmetric transformation is treated with a strong inorganic acid without the formed, precipitated diastereoisomeric salt of the optically active phenylglycine derivative and the optically active acid being isolated and dissolved beforehand. Preferably, the amide or an ester of a phenylglycine is used as the phenylglycine derivative, which phenylglycine may or may not be substituted, in particular phenylglycine or p-hydroxyphenylglycine. As the strong inorganic acid use is preferably made of an acid having a pKa value that is smaller than the pKa value of the optically active acid. Particularly suitable inorganic acids are for example mineral acids, in particular sulphuric acid or hydrochloric acid, (gaseous or in solution). A particularly good embodiment is obtained when hydrochloric acid is used, for it has been found that the use of an eguivalent amount of hydrochloric acid relative to the amount of diastereoisomeric salt results in an almost quantitative conversion. In the application of the process according to the invention to the reaction mixture obtained after an asymmetric transformation, in particular, this presents the advantage that no inorganic salt is present in the mother liquor that remains after the recovery of the phenylglycine derivative.HC1 salt. As a result, the mother liquor containing the optically active acid obtained in the conversion can be returned as such to the asymmetric transformation, for it has been found that the presence of inorganic acid interferes with the asymmetric transformation reaction, in particular the racemization. The temperature at which the treatment with the strong inorganic acid takes place is not critical and preferably lies between 0 and 125°C, in particular between 20 and 80°C. In practice, when the treatment is applied to a reaction mixture obtained after an asymmetric transformation, it will usually take place at a temperature that is the same as or lower than the temperature at which the asymmetric transformation is carried out. The pressure at which the treatment with the strong inorganic acid takes place is not critical either and will usually lie between 0.01 and 1 MPa, in particular between 0.05 and 0.2 MPa. Preferably the treatment with the strong inorganic acid is carried out at atmospheric pressure. Carbonyl compounds that can be used in the asymmetric transformation are for example aldehydes or ketones, in particular aromatic aldehydes, for example benzaldehyde, anisealdehyde, o-, p- or m-nitro-benzaldehyde, o-, p- or m-chlorobenzaldehyde or aliphatic aldehydes, for example isobutyraldehyde or isovaleraldehyde, ketones, for example methylisobutyl-ketone, butanone or acetone. The amount of carbonyl compound to be added is preferably 0.5-4.0 equivalents relative to the amount of phenylglycine derivative, in particular 1-2 equivalents. Instead of starting from a mixture of L- and D-phenylglycine derivatives and a carbonyl compound, it is also possible to start from a mixture of the Schiff bases of L- and D-phenylglycine derivatives. In this case it is not strictly necessary to add an extra amount of carbonyl compound. In this case, in order to obtain an optimum yield of the diastereoisomeric salt of optically active phenylglycine derivative and optically active acid, an amount of water that is at least equimolar relative to the amount of Schiff base must be added. The use of less than an equimolar amount of water leads to a virtually proportional decrease in the yield. In the asymmetric transformation use is made of optically active acids, for example carboxylic acids. Suitable examples of optically active acids are mandelic acid, tartaric acid, 2-pyrrolidone-5-carboxylic acid and N-acetylphenylglycine. The acidity (pKa) will usually be between 3 and 5. The amount of optically active acid to be used may vary within a wide range and will generally lie between 0.9 and 1.2 equivalents of optically active acid relative to the amino acid amide. Preferably, an equivalent amount of carboxylic acid is used. Suitable solvents for the asymmetric transformation are for example hydrocarbons/ for example cyclohexane, heptane and octane, aromatic hydrocarbons such as toluene, xylene and benzene, ethers, for example methvl-tertiarv-butyl ether, dioxane, tetrahydrofuran and anisole, esters, for example butyl acetate and ethyl acetate, ketones, for example acetone, butanone, methylisobutylketone, carboxylic acids, aldehydes or mixtures of these substances. It will be clear that the solvent must be chosen so that it does not enter into irreversible chemical reactions with the amino acid amide, the optically active carboxylic acid or the aldehyde. The pressure at which the asymmetric transformation is carried out is not critical and usually lies between 0.01 and 1 MPa, in particular 0.05 and 0.2 MPa. Preferably, the process is carried out at atmospheric pressure. The temperature at which the asymmetric transformation is carried out may vary within a wide range and is generally 70-120°C, preferably 75-100°C, in particular 80-90°C. The reaction time is usually 1-8 hours, preferably 1-4 hours. The slurry concentration of the diastereoisomeric salts at the end of the reaction is about 5-30 wt.%, preferably 10-20 wt.%. The invention will now be elucidated with reference to the following examples, without being limited thereto. CLAIMS 1. Process for the preparation of an inorganic salt of an optically active phenylglycine derivative in which a diastereoisomeric salt of the optically active phenylglycine derivative and an optically active acid is treated with a strong inorganic acid, characterised in that at least a portion of the strong inorganic acid is added to a mixture containing an amount of the diastereoisomeric salt as a solid substance. 2. Process according to Claim 1, in which a phenylglycineamide or an ester of a phenylglycine is used as the phenylglycine derivative. 3. Process according to Claim 1 or Claim 2, in which hydrochloric acid or sulphuric acid is used as the strong acid. 4. Process according to Claim 3, in which an almost eguivalent amount of hydrochloric acid is used as the strong acid. 5. Process according to any one of Claims 1-4, in which phenylglycineamide or p-hydroxyphenyl-glycineamide is used as the phenylglycine derivative. 6. Process according to any one of Claims 1-5, in which the optically active acid is optically active mandelic acid, tartaric acid, 2-pyrrolidone-5-carboxylic acid or N-acetylphenyl-glycine. 7. Process according to any one of Claims 1-6, in which the mixture consists of the reaction mixture obtained after an asymmetric transformation in which a mixture of the L- and D-enantiomers of the phenylglycine derivative is partly or entirely converted into the diastereoisomeric salt in the presence of a carbonyl compound with the aid of the optically active acid. 8 Process according to any one of Claims 1-6, in which the mixture consists of the reaction mixture obtained after an asymmetric transformation in which a mixture of the L- and D-enantiomers of a Schiff base of the phenylglycine derivative is partly or entirely converted into the diastereoisomeric salt with the aid of the optically active acid. Process for the preparation of an inorganic salt of a phenylglycine derivative as described and elucidated with reference to the examples. 10. Process for the preparation of an inorganic salt substantially as herein described and exemplified. DATED THIS 16th DAY OF SEPTEMBER 1997 (R R of DePENNING & DePENNING AGENT FOR THE APPLICANT

Documents:

2058-mas-1997-abstract.pdf

2058-mas-1997-claims.pdf

2058-mas-1997-correspondence others.pdf

2058-mas-1997-correspondence po.pdf

2058-mas-1997-description complete.pdf

2058-mas-1997-form 1.pdf

2058-mas-1997-form 26.pdf

2058-mas-1997-form 3.pdf

2058-mas-1997-form 4.pdf

2058-mas-1997-pct.pdf