Title of Invention | AN IMPROVED PROCESS FOR THE PREPARATION OF 5-[4[2-(N-METHYL-N-(2-PYRIDYL) AMINO) ETHOXY]-BENZYL]-2, 4-THIAZOLIDINEDIONE MALEATE (ROSIGLITAZONE MALEATE) |
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Abstract | An improved process for the preparation of maleate salt of 5-[4-[2-(N-methyl- N -(2-pyridyl)amino )ethoxy ]-benzyl]thiazolidine -2,4-dione (Rosiglitazone maleate), which comprises reduction of 5-[4-[2-(N-methyl-N-(2- pyridyl)amino )ethoxy ]-benzylidene ]-2,4-thiazolidinedione in presence of cobalt ion/bidentate ligand! sodium borohydride/potassium borohydride catalyst system and subsequent conversion of the 5-[4-[2-(N-methyl-N-(2- pyridyl)amino )ethoxy]-benzyl]thi~zolidine-2,4-dione thus obtained to its maleate salt. The improved method of preparation of Rosiglitazone and its pharmaceutically acceptable salts is cost effective, commercially viable and industrially suited. |
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262-MAS-2001 CORRESPONDENCE OTHERS.pdf
262-MAS-2001 CORRESPONDENCE PO.pdf
262-MAS-2001 DESCRIPTION (COMPLETE).pdf
Patent Number | 192995 | ||||||||||||
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Indian Patent Application Number | 262/MAS/2001 | ||||||||||||
PG Journal Number | 02/2006 | ||||||||||||
Publication Date | 13-Jan-2006 | ||||||||||||
Grant Date | 21-Nov-2005 | ||||||||||||
Date of Filing | 21-Mar-2001 | ||||||||||||
Name of Patentee | DR. REDDY'S LABORATORIES LIMITED | ||||||||||||
Applicant Address | 7-1-27, AMEERPET, HYDERABAD 500 016, | ||||||||||||
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PCT International Classification Number | C07D277/00 | ||||||||||||
PCT International Application Number | N/A | ||||||||||||
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