Title of Invention

AN IMPROVED PROCESS FOR THE PREPARATION OF 5-[4[2-(N-METHYL-N-(2-PYRIDYL) AMINO) ETHOXY]-BENZYL]-2, 4-THIAZOLIDINEDIONE MALEATE (ROSIGLITAZONE MALEATE)

Abstract An improved process for the preparation of maleate salt of 5-[4-[2-(N-methyl- N -(2-pyridyl)amino )ethoxy ]-benzyl]thiazolidine -2,4-dione (Rosiglitazone maleate), which comprises reduction of 5-[4-[2-(N-methyl-N-(2- pyridyl)amino )ethoxy ]-benzylidene ]-2,4-thiazolidinedione in presence of cobalt ion/bidentate ligand! sodium borohydride/potassium borohydride catalyst system and subsequent conversion of the 5-[4-[2-(N-methyl-N-(2- pyridyl)amino )ethoxy]-benzyl]thi~zolidine-2,4-dione thus obtained to its maleate salt. The improved method of preparation of Rosiglitazone and its pharmaceutically acceptable salts is cost effective, commercially viable and industrially suited.
Full Text

Documents:

262-MAS-2001 CLAIMS.pdf

262-MAS-2001 CORRESPONDENCE OTHERS.pdf

262-MAS-2001 CORRESPONDENCE PO.pdf

262-MAS-2001 DESCRIPTION (COMPLETE).pdf

262-MAS-2001 FORM-1.pdf


Patent Number 192995
Indian Patent Application Number 262/MAS/2001
PG Journal Number 02/2006
Publication Date 13-Jan-2006
Grant Date 21-Nov-2005
Date of Filing 21-Mar-2001
Name of Patentee DR. REDDY'S LABORATORIES LIMITED
Applicant Address 7-1-27, AMEERPET, HYDERABAD 500 016,
Inventors:
# Inventor's Name Inventor's Address
1 SRINIVASAN THIRUMALAI RAJAN DR. REDDY'S LABORATORIES LIMITED, 7-1-27, AMEERPET, HYDERABAD 500 016,
2 MANDAVA VENKATA NAGABRAHNESWAR RAO DR. REDDY'S LABORATORIES LIMITED, 7-1-27, AMEERPET, HYDERABAD 500 016,
3 MANNE SATYANARYANA REDDY DR. REDDY'S LABORATORIES LIMITED, 7-1-27, AMEERPET, HYDERABAD 500 016,
PCT International Classification Number C07D277/00
PCT International Application Number N/A
PCT International Filing date
PCT Conventions:
# PCT Application Number Date of Convention Priority Country
1 NA