Title of Invention	" AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAMATES USEFUL FOR AGROCHEMICALS, PHARMACEUTICALS AND PEPTIDE SYNTHESIS"
Abstract	An improved process for the preparation of carbamates of formula 1 as given in the drawing sheet wherein R=aryl; heterocyclic alkyl, poly nuclear arene, juranase pvranosefe amino acid or protected amino acid R1 is methyl, ethyl, isobutyl or benzyl useful for agrochemicals, Pharmaceuticals and peptide synthesis which composes reacting a halo formate with an amino substrate selected from straight chain/branched (C3-C15), aromatic, heterocyclic or protected amino acid (mono & di acid) or hydroxyl protected carbohydrates in presence of a condensing agent selected from transition metal in a ratio ranging from 0.3 to 1.7 mol% by wt. in an organic solvent at a temperature in the range of 25 to 80°C. for a period in the range of 8-360 minutes, recovering the carbamates by conventional methods.

Title of Invention

" AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAMATES USEFUL FOR AGROCHEMICALS, PHARMACEUTICALS AND PEPTIDE SYNTHESIS"

Abstract

An improved process for the preparation of carbamates of formula 1 as given in the drawing sheet wherein R=aryl; heterocyclic alkyl, poly nuclear arene, juranase pvranosefe amino acid or protected amino acid R1 is methyl, ethyl, isobutyl or benzyl useful for agrochemicals, Pharmaceuticals and peptide synthesis which composes reacting a halo formate with an amino substrate selected from straight chain/branched (C3-C15), aromatic, heterocyclic or protected amino acid (mono & di acid) or hydroxyl protected carbohydrates in presence of a condensing agent selected from transition metal in a ratio ranging from 0.3 to 1.7 mol% by wt. in an organic solvent at a temperature in the range of 25 to 80°C. for a period in the range of 8-360 minutes, recovering the carbamates by conventional methods.

Full Text	This invention relates to an improved process for the preparation of carbamates useful for agrochemicals, Pharmaceuticals and peptide synthesis This invention particularly describes a process for the preparation of carbamates which find applications in agrochemicals , Pharmaceuticals and in peptide synthesis The process is suitable for the preparation of a variety of alkyl, aryl, ammo acid and carbohydrates carbamates of formula 1 wherein R is aryl, hetero cyclic, alkyl, poly nuclear arene, furanose, pyranose ammo acid (where acid group is protected as methyl or ethyl) or the add group of ammo acid is converted into alcohol and protected with trimethyl silyl group and R1 is methyl, ethyl, isobutyl or benzyl Carbamates find applications in Pharmaceuticals as well as in agrochemicals. They are well known in agrochemicals as pesticides, insecticides and herbicides that require in large quantihes. The present process can meet with the demands in more economic way. The present invention also finds application in peptide synthesis where this method stands with other protected groups This allows the process to prepare carbamates at a specific functionalized group dunng the synthetic sequence. Further the present invention also finds application carbohydrate carbamates formation. Several processes have been published hitherto for the production of compounds of this type 1 Ammo compounds are converted into N-acyl hahde (>N-COC1) using phosgene.Further it is reacted with alcohols in the presence of triethylamme as base in aromatic solvent at higher temperature. But the yields obtained are very low (49%). (Jpn. Kokai Tokyo, koho81.71,058,1981), (Jpn. Kokai. Tokyo, koho 8125,143,1981). 2. Aromatic carbamates are prepared by the condensation of amines with anhydride in °. oresence of metal salts or salt of monovalent organic compounds. This process particularly has the drawback that the side products like PhNHCONHPh and PhNHMe anses.(U.S.Patent 4268683,1981). 3. Amines are treated with CO, alcohols and VII group metal compounds like PdCl? using pressure 1000 psi. The reaction completes after 24 hrs at 120 °C.The disadvantages of this process are the use of palladium salt which is expensive and the reaction time is very long (U.S.patent 4260781,1981) 4 A method using diethylcarbonate needs sodium hydnde as base which is moisture sensitive (SyntkCommun 1994, 24, 2441) These processes are based on the applications of tn ethylamme, sodium hydride as co-base where other protecting groups can not service Moreover, these procedures use hazardous chemicals like phosgene and isocyanate, which are very expensive and difficult to handle. Some times the procedures require heating, high pressure and longer reaction time and does not lead to satisfactory yield Therefore, all these procedures have no commercial significance These processes of carbamates production using phosgene, isocyanate, anhydride and triethyl amine as base, have the following disadvantages. 1 To complete the reaction, it is necessary to use base, which may effect the other protecting groups 2 Triethyl amine and sodium hydnde used as co-base are difficult to handle because of its high sensitivity towards moisture 3 The bases or metal salt of organic compounds used are in equivalent amount and are not recoverable which unnecessarily produce large waste effluent and effect the process cost 4 Phosgene or isocynate used are highly hazardous and difficult to handle This necessitates especially in a commercial scale in a highly safety oriented expenditure which has a negative influence on the economic viability of such process 5 The use of anhydride produces unnecessary waste of one mole of acid, which is not recoverable, and it goes as effluent discharge 6. The above mentioned processes have the drawback of using bases, hazardous chemicals like phosgene, isocynates and metal salts of organic compounds. In order to achieve the highest possible degree of conversion, these methods need high pressure, high temperature and longer reaction time. The main objective of the present invention is to provide a process for the preparation of carbamates useful in agrochemicals, Pharmaceuticals and in peptide synthesis Another object of the invention is to develop a process with out the use of triethyi amine and other hazardous chemicals Yet another object of the invention is to produce such compounds using readily available haloformates and amines in the presence of transition metal powder which is recoverable reused again and also avoid the use of hazardous chemicals or bases like tnethylarnine and sodium hydride or anhydride or any high pressure for the reaction A feature of the invention is that the reaction is earned out in the presence of transition metals The conversions are quantitative within few minutes at room temperature. Ail the above mentioned unfavorable phenomena connected with the use of triethyi amine, phosgene, isocynate, and anhydride are thereby avoided Still another object of the invention is to recycle and reuse the condenspg agent (here metal powder) which would minimize the quantity of waste effluent in large scale Further object of the invention is broaden to the ammo acid carbamate and carbohydrate carbamates where the present process allows the stability of other protecting groups like esters, acetonides and silyl in the same conditions The process permits the quantitative production of the end products Accordingly, the present invention provides an improved process for the preparation of carbamates of formula 1 wherein R=aryl, heterocyclic alkyl, poly nuclear arene, juranase pyranose/ amino acid or protected ammo acid R1 is methyl, ethyl, isobutyl or benzyl useful for agrochemicals, Pharmaceuticals and peptide synthesis which comprises reacting a halo formate with an amino substrate selected from straight chain/branched (C3-C15), aromatic, heterocyclic or protected amino acid (mono & di acid) or hydroxyl protected carbohydrates in presence of a condensing agent selected from transition metal in a ratio ranging from 0.3 to 1 7 mol% by wt. in an organic solvent at a temperature m the range of 25 to 80°C. for a period in the range of 8-360 minutes, recovering the carbamates by conventional methods. In an embodiment of the present invention the halo formates used are benzyl, atkyl, phenyl. isobutyl haloformates. In another embodiment of the present invention the amme used may be such as straight chain or branched (C3-C15), aromatic or hetrocyclic, protected amino acids, or hydroxyi protected carbohydrates In yet another embodiment of the present invention the transition metals used are Cu. Cd. Zn. Fe and mixtures thereof , Still another embodiment of the present invention the condensing agent used may be in the range ofO.3-1.7-mol. The present inventor found that it is considerably advantageous to use readily available haloformates. as phosgene equivalent and transition metals such as Cu. Cd. Zn. Fe as condensing agents. Suitable transition metals are either M+2 or M+3 or normally a mixture of two to achieve the maximum condensation of amines with haloformates. A mixture of metal powder like copper: zinc 0:1); cadmium: iron (1:1), iron:zmc (1.1); zinc: cadmium (1'1); coppencadmium (1:1) also can be used with good results. The condensing agent comes in quantities of 0,3 moles to 1.7 moles % based on the reactants for application purpose. The present invention for the preparation of carbamates using amines and haloformates. and metal powder as a condensing agent has the following advantages against the hitherto known processes. The reaction partners can influence each other in different ways. Thus, the haloformates and metal powder can be used together and the amme can be added later or the haloformates are added to the The present invention is illustrated by the following examples, it should not construed, that limit and scope of the invention Example-1 Aliphatic Carbamates Benzyl chloroformate (0 3 mole) and metal powder (Cu Zn, 1 1, 0 09 mole) is stirred in benzene and then 1-amino hexane (0 3 mole) is added The reaction is completed within 8 minutes It is filtered and solid washed with diethyl ether and filtrate is neutralized with sodium bicarbonate(10%) Evaporation of the solvent gives benzyl- N-(n-hexyl) carbamate in a good yield (95%) Example-2 Aromatic Carbamates A mixture of ethyl chlorofomate (0 3 mol) and metals powder (Cd Zn 1 1, 0 09 mole) is stirred in benzene Later the 4-methoxy aniline (0 3 aiole) is added with stirrmg. Stirring was continued for 9 minutests, after deposition of the product, it is filtered solid washed with diethyl ether and filtrate neutralized with sodium bicarbonate (10%). After distilling the solvent, the ethyl- N- (4-methoxyphenyl) carbamate is obtained in good yield ( 96%) Example-3 Amino acid Carbamates: A mixture of isobutyl chloroformate(0 3 mol) and metal powder (Fe Zn, 1 1, 0 12 mole) is stirred in benzene, then the benzene solution of methyl-2-amino-4-phenyl-butanoate (03 mole) is added and stirring is continued for 18 minutes The reaction mixture is filtered and solid washed with diethyl ether and neutralized with sodium bicarbonate (10%) After distilling the solvent, the isobutyl-N-2(methyl-4-phenyl butanoate) carbamate obtained in high yield (98%) Example-4 Carbohydrates Carbonates: Benzyl chloro formate (0 3mol), metals powder (Zn : Cd, 1 1, 0.12 mole) is stirred in benzene for 5 minutes further 2-Amino furanose (0 3 mole) is added and the reaction mixture stirred for 15 minutes The reaction mixture is filtered and solid washed with diethyl ether and filtrate is neutralized with sodium bicarbonate (10%) Evaporation of the solvent gives benzyl-N- furanosyl carbamate in good yield (94%) The advantages of the present invention are: The present invention for the preparation of carbamates using amines, haloformates and mi powder as a condensing agent has the following advantages against the hitherto knojwfi processes 1 The moisture sensitive bases can be substituted by using transition metals, which also allow the process for the preparation of functionalized carbamate, for example in ammo acids and in carbohydrates 2 The use of expensive and hazardous chemicals like phosgene and isocyanate are avoided which decisively reduce the cost of safety precautions 3 The catalyst, transition metal powder used are nor totally consumed which can be recovered and reused, thereby the expenditure related to condensing agent is reduced to a greater extent. 4 Because of the recovery of condensing agent, the unnecessary waste effluents are minimized 5 The reaction temperature can be decisively reduced Temperature necessary for this process lies in the range between room temperature to 80 ° C 6 The reaction time also can be reduced to a greater extent. They are normally below 10 minutes. 7 In spite of the lower temperature and shorter reaction time the yield of the product are quantitatively ranges between 90-98 % We claim: 1. An improved process for the preparation of carbamates of formula 1 given in the drawing sheet wherein R=aryl, heterocyclic aikyi, poly nuclear arene, Juranase pyranose ammo acid or protected amino acid R1 is methyl, ethyl, isobutyl or benzyl useful for agrochemicals, Pharmaceuticals and peptide synthesis which comprises reacting a halo formate with an amino substrate selected from straight chain/branched (C3-C15), aromatic, heterocyclic or protected amino acid (mono & di acid) or hydroxy! protected carbohydrates in presence of a condensing agent selected from transition metal in a ratio ranging from 0.3 to 1.7 mol% by wt in an organic solvent at a temperature in tie range of 25 to 80°C. for a period in the range of 8-360 minutes, recovering the carbamates by conventional methods. 2. An improved process as claimed in claim I wherein the hatoformates used is such as benzyl, ethyl, isobutyl or substituted benzyl haloformates. 3. An improved process as claimed in claims 1 to 2 wherein the transition metals used am Cu. Cd. Fe, Zn and mixtures thereof. 4. An improved process as claimed in claims 1 to 3 wherein the aromatic hydrocarbon solvent used are benzene, toluene or xylene. 5. An improved process for the preparation of carbamates useful for agrochemicals, Pharmaceuticals and peptide synthesis substantially as herein described with references to the examples and drawing accompanying this specification.

Full Text

This invention relates to an improved process for the preparation of carbamates useful for agrochemicals, Pharmaceuticals and peptide synthesis
This invention particularly describes a process for the preparation of carbamates which find applications in agrochemicals , Pharmaceuticals and in peptide synthesis The process is suitable for the preparation of a variety of alkyl, aryl, ammo acid and carbohydrates carbamates of formula 1 wherein R is aryl, hetero cyclic, alkyl, poly nuclear arene, furanose, pyranose ammo acid (where acid group is protected as methyl or ethyl) or the add group of ammo acid is converted into alcohol and protected with trimethyl silyl group and R1 is methyl, ethyl, isobutyl or benzyl
Carbamates find applications in Pharmaceuticals as well as in agrochemicals. They are well known in agrochemicals as pesticides, insecticides and herbicides that require in large quantihes. The present process can meet with the demands in more economic way.
The present invention also finds application in peptide synthesis where this method stands with other protected groups This allows the process to prepare carbamates at a specific functionalized group dunng the synthetic sequence. Further the present invention also finds application carbohydrate carbamates formation.
Several processes have been published hitherto for the production of compounds of this type
1 Ammo compounds are converted into N-acyl hahde (>N-COC1) using
phosgene.Further it is reacted with alcohols in the presence of triethylamme as base in aromatic solvent at higher temperature. But the yields obtained are very low (49%). (Jpn. Kokai Tokyo, koho81.71,058,1981), (Jpn. Kokai. Tokyo, koho 8125,143,1981). 2. Aromatic carbamates are prepared by the condensation of amines with anhydride in °. oresence of metal salts or salt of monovalent organic compounds. This process particularly has the drawback that the side products like PhNHCONHPh and PhNHMe anses.(U.S.Patent 4268683,1981).
3. Amines are treated with CO, alcohols and VII group metal compounds like PdCl? using pressure 1000 psi. The reaction completes after 24 hrs at 120 °C.The disadvantages of this process are the use of palladium salt which is expensive and the reaction time is very long (U.S.patent 4260781,1981)
4 A method using diethylcarbonate needs sodium hydnde as base which is moisture sensitive (SyntkCommun 1994, 24, 2441)
These processes are based on the applications of tn ethylamme, sodium hydride as co-base where other protecting groups can not service Moreover, these procedures use hazardous chemicals like phosgene and isocyanate, which are very expensive and difficult to handle. Some times the procedures require heating, high pressure and longer reaction time and does not lead to satisfactory yield Therefore, all these procedures have no commercial significance These processes of carbamates production using phosgene, isocyanate, anhydride and triethyl amine as base, have the following disadvantages.
1 To complete the reaction, it is necessary to use base, which may effect the other
protecting groups
2 Triethyl amine and sodium hydnde used as co-base are difficult to handle because of its
high sensitivity towards moisture
3 The bases or metal salt of organic compounds used are in equivalent amount and are not
recoverable which unnecessarily produce large waste effluent and effect the process
cost
4 Phosgene or isocynate used are highly hazardous and difficult to handle This
necessitates especially in a commercial scale in a highly safety oriented expenditure
which has a negative influence on the economic viability of such process
5 The use of anhydride produces unnecessary waste of one mole of acid, which is not
recoverable, and it goes as effluent discharge
6. The above mentioned processes have the drawback of using bases, hazardous chemicals like phosgene, isocynates and metal salts of organic compounds. In order to achieve the
highest possible degree of conversion, these methods need high pressure, high temperature and longer reaction time.
The main objective of the present invention is to provide a process for the preparation of carbamates useful in agrochemicals, Pharmaceuticals and in peptide synthesis
Another object of the invention is to develop a process with out the use of triethyi amine and other hazardous chemicals
Yet another object of the invention is to produce such compounds using readily available haloformates and amines in the presence of transition metal powder which is recoverable reused again and also avoid the use of hazardous chemicals or bases like tnethylarnine and sodium hydride or anhydride or any high pressure for the reaction A feature of the invention is that the reaction is earned out in the presence of transition metals The conversions are quantitative within few minutes at room temperature.
Ail the above mentioned unfavorable phenomena connected with the use of triethyi amine, phosgene, isocynate, and anhydride are thereby avoided
Still another object of the invention is to recycle and reuse the condenspg agent (here metal powder) which would minimize the quantity of waste effluent in large scale Further object of the invention is broaden to the ammo acid carbamate and carbohydrate carbamates where the present process allows the stability of other protecting groups like esters, acetonides and silyl in the same conditions The process permits the quantitative production of the end products
Accordingly, the present invention provides an improved process for the preparation of carbamates of formula 1 wherein R=aryl, heterocyclic alkyl, poly nuclear arene, juranase pyranose/ amino acid or protected ammo acid R1 is methyl, ethyl, isobutyl or benzyl useful for agrochemicals, Pharmaceuticals and peptide synthesis which comprises reacting a halo formate with an amino substrate selected from straight chain/branched (C3-C15), aromatic, heterocyclic or protected amino acid (mono & di acid) or hydroxyl protected carbohydrates in presence of a condensing agent selected from transition metal in a ratio ranging from 0.3 to 1 7 mol% by wt. in an organic solvent at a temperature m the range of 25 to 80°C. for a period in the range of 8-360 minutes, recovering the carbamates by conventional methods.
In an embodiment of the present invention the halo formates used are benzyl, atkyl, phenyl. isobutyl haloformates.
In another embodiment of the present invention the amme used may be such as straight chain or branched (C3-C15), aromatic or hetrocyclic, protected amino acids, or hydroxyi protected carbohydrates
In yet another embodiment of the present invention the transition metals used are Cu. Cd. Zn. Fe and mixtures thereof ,
Still another embodiment of the present invention the condensing agent used may be in the range ofO.3-1.7-mol.
The present inventor found that it is considerably advantageous to use readily available haloformates. as phosgene equivalent and transition metals such as Cu. Cd. Zn. Fe as condensing agents. Suitable transition metals are either M+2 or M+3 or normally a mixture of two to achieve the maximum condensation of amines with haloformates. A mixture of metal powder like copper: zinc 0:1); cadmium: iron (1:1), iron:zmc (1.1); zinc: cadmium (1'1); coppencadmium (1:1) also can be used with good results. The condensing agent comes in quantities of 0,3 moles to 1.7 moles % based on the reactants for application purpose. The present invention for the preparation of carbamates using amines and haloformates. and metal powder as a condensing agent has the following advantages against the hitherto known processes.
The reaction partners can influence each other in different ways. Thus, the haloformates and metal powder can be used together and the amme can be added later or the haloformates are added to the
The present invention is illustrated by the following examples, it should not construed, that limit and scope of the invention
Example-1 Aliphatic Carbamates
Benzyl chloroformate (0 3 mole) and metal powder (Cu Zn, 1 1, 0 09 mole) is stirred in benzene and then 1-amino hexane (0 3 mole) is added The reaction is completed within 8 minutes It is filtered and solid washed with diethyl ether and filtrate is neutralized with sodium bicarbonate(10%) Evaporation of the solvent gives benzyl- N-(n-hexyl) carbamate in a good yield (95%)
Example-2 Aromatic Carbamates
A mixture of ethyl chlorofomate (0 3 mol) and metals powder (Cd Zn 1 1, 0 09 mole) is stirred in benzene Later the 4-methoxy aniline (0 3 aiole) is added with stirrmg. Stirring was continued for 9 minutests, after deposition of the product, it is filtered solid washed with diethyl ether and filtrate neutralized with sodium bicarbonate (10%). After distilling the solvent, the ethyl- N- (4-methoxyphenyl) carbamate is obtained in good yield ( 96%)
Example-3 Amino acid Carbamates:
A mixture of isobutyl chloroformate(0 3 mol) and metal powder (Fe Zn, 1 1, 0 12 mole) is stirred in benzene, then the benzene solution of methyl-2-amino-4-phenyl-butanoate (03 mole) is added and stirring is continued for 18 minutes The reaction mixture is filtered and solid washed with diethyl ether and neutralized with sodium bicarbonate (10%) After distilling the solvent, the isobutyl-N-2(methyl-4-phenyl butanoate) carbamate obtained in high yield (98%)
Example-4 Carbohydrates Carbonates:
Benzyl chloro formate (0 3mol), metals powder (Zn : Cd, 1 1, 0.12 mole) is stirred in benzene for 5 minutes further 2-Amino furanose (0 3 mole) is added and the reaction mixture stirred for 15 minutes The reaction mixture is filtered and solid washed with diethyl ether and filtrate is neutralized with sodium bicarbonate (10%) Evaporation of the solvent gives benzyl-N- furanosyl carbamate in good yield (94%)
The advantages of the present invention are:
The present invention for the preparation of carbamates using amines, haloformates and mi powder as a condensing agent has the following advantages against the hitherto knojwfi processes
1 The moisture sensitive bases can be substituted by using transition metals, which also
allow the process for the preparation of functionalized carbamate, for example in ammo
acids and in carbohydrates
2 The use of expensive and hazardous chemicals like phosgene and isocyanate are
avoided which decisively reduce the cost of safety precautions
3 The catalyst, transition metal powder used are nor totally consumed which can be
recovered and reused, thereby the expenditure related to condensing agent is reduced to
a greater extent.
4 Because of the recovery of condensing agent, the unnecessary waste effluents are
minimized
5 The reaction temperature can be decisively reduced Temperature necessary for this
process lies in the range between room temperature to 80 ° C
6 The reaction time also can be reduced to a greater extent. They are normally below 10
minutes.
7 In spite of the lower temperature and shorter reaction time the yield of the product are
quantitatively ranges between 90-98 %

We claim:
1. An improved process for the preparation of carbamates of formula 1
given in the drawing sheet
wherein R=aryl, heterocyclic aikyi, poly nuclear arene, Juranase pyranose
ammo acid or protected amino acid R1 is methyl, ethyl, isobutyl or benzyl useful for agrochemicals, Pharmaceuticals and peptide synthesis which comprises reacting a halo formate with an amino substrate selected from straight chain/branched (C3-C15), aromatic, heterocyclic or protected amino acid (mono & di acid) or hydroxy! protected carbohydrates in presence of a condensing agent selected from transition metal in a ratio ranging from 0.3 to 1.7 mol% by wt in an organic solvent at a temperature in tie range of 25 to 80°C. for a period in the range of 8-360 minutes, recovering the carbamates by conventional methods.
2. An improved process as claimed in claim I wherein the hatoformates used
is such as benzyl, ethyl, isobutyl or substituted benzyl haloformates.
3. An improved process as claimed in claims 1 to 2 wherein the transition
metals used am Cu. Cd. Fe, Zn and mixtures thereof.
4. An improved process as claimed in claims 1 to 3 wherein the aromatic
hydrocarbon solvent used are benzene, toluene or xylene.
5. An improved process for the preparation of carbamates useful for
agrochemicals, Pharmaceuticals and peptide synthesis substantially as
herein described with references to the examples and drawing
accompanying this specification.

Documents:

276-del-1999-abstract.pdf

276-del-1999-claims(cancelled).pdf

276-del-1999-claims.pdf

276-del-1999-complete specification (granted).pdf

276-del-1999-correspondence-others.pdf

276-del-1999-correspondence-po.pdf

276-del-1999-description (complete).pdf

276-del-1999-drawings.pdf

276-del-1999-form-1.pdf

276-DEL-1999-Form-2.pdf

276-del-1999-form-3.pdf

276-del-1999-form-4.pdf

276-del-1999-form-9.pdf

abstract.jpg

« Previous Patent

Next Patent »

Patent Number

190829

Indian Patent Application Number

276/DEL/1999

PG Journal Number

31/2009

Publication Date

31-Jul-2009

Grant Date

16-Mar-2004

Date of Filing

19-Feb-1999

Name of Patentee

COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH,

Applicant Address

RAFI MARG NEW DELHI-110001, INDIA.

Inventors:

#	Inventor's Name	Inventor's Address
1	JHILLU SINGH YADAV	INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY , HYDERABAD-500007, A.P.INDIA.
2	HARSHADAS MITARAM MESHRAM	INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY , HYDERABAD-500007, A.P.INDIA.
3	GONDI SUDERSHAN REDDY	INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY , HYDERABAD-500007, A.P.INDIA.

PCT International Classification Number

A61K 31/00

PCT International Application Number

N/A

PCT International Filing date

PCT Conventions:

#	PCT Application Number	Date of Convention	Priority Country
1			NA